Harvard Catalyst Profiles

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Juan M. Melero-Martin, Ph.D.

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Overview
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Stem cell transplantation and tissue engineering hold great promise in regenerative medicine. However, engrafting stem cells and generating tissues with stable vascular beds remain major challenges. Our laboratory is interested in understanding mechanisms of vascular network formation and stem cell engraftment using human stem and progenitor cells. Our long-term goal is to develop novel therapeutic strategies in regenerative medicine. Current projects in the lab are focused on:

1) Endothelial progenitor cell biology and therapeutic potential
2) Bioengineering vascular networks
3) Genetically-engineered vasculature for drug delivery

Please visit our website for more information:
meleromartinlab.com
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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01HL172968 (MELERO-MARTIN, JUAN M) May 7, 2024 - Apr 30, 2028
    NIH
    A Novel Transcription Factor-Driven Approach for Mural Progenitor Cells Generation
    Role: Principal Investigator
  2. R01HL171405 (YUAN, KE) Jan 1, 2024 - Dec 31, 2027
    NIH
    Pericyte contribution to capillary remodeling in pulmonary arterial hypertension
    Role: Co-Principal Investigator
  3. R01AR080086 (MELERO-MARTIN, JUAN M) Aug 10, 2022 - May 31, 2027
    NIH
    Human endothelial cell regulation of ossification
    Role: Principal Investigator
  4. R01HL151450 (PU, WILLIAM TSWENCHING) Feb 15, 2021 - Jan 31, 2025
    NIH
    Regulation of endothelial cell specification
    Role: Co-Principal Investigator
  5. R01HL152133 (MELERO-MARTIN, JUAN M) Dec 20, 2020 - Nov 30, 2024
    NIH
    Enhancing endothelial cell engraftment via transplantation of exogenous mitochondria
    Role: Principal Investigator

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© 2024 President and Fellows of Harvard College
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.