SCB4StephenBlacklowStephen Charles Blacklow, M.D., Ph.D.42.33837200000000-71.1032690000000045189Blacklow, StephenCharles617/432-5176Gustavus Adolphus Pfeiffer Professor of Biological Chemistry and Molecular Pharmacologycatalyst:eCommonsLogineCommons Loginprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:address2address line 2vivo:address3address line 3vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:middleNamemiddle name or initialvivo:personInPositionpositionsvivo:phoneNumberphonePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofvivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson16271878Blacklow SCStructure (London, England : 1993)A new niche for Notch on Deltex? Structure. 2005 Nov; 13(11):1579-80.Structure2005-11-01T00:00:002005A new niche for Notch on Deltex?11101851Wu L, Aster JC, Blacklow SC, Lake R, Artavanis-Tsakonas S, Griffin JDNature geneticsMAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors. Nat Genet. 2000 Dec; 26(4):484-9.Nat Genet2000-12-01T00:00:002000MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors.11264341Adkins HB, Blacklow SC, Young JAJournal of virologyTwo functionally distinct forms of a retroviral receptor explain the nonreciprocal receptor interference among subgroups B, D, and E avian leukosis viruses. J Virol. 2001 Apr; 75(8):3520-6.J Virol2001-04-01T00:00:002001Two functionally distinct forms of a retroviral receptor explain the nonreciprocal receptor interference among subgroups B, D, and E avian leukosis viruses.12754376Forster AC, Tan Z, Nalam MN, Lin H, Qu H, Cornish VW, Blacklow SCProceedings of the National Academy of Sciences of the United States of AmericaProgramming peptidomimetic syntheses by translating genetic codes designed de novo. Proc Natl Acad Sci U S A. 2003 May 27; 100(11):6353-7.Proc Natl Acad Sci U S A2003-05-16T00:00:002003Programming peptidomimetic syntheses by translating genetic codes designed de novo.2691332Hermes JD, Parekh SM, Blacklow SC, Köster H, Knowles JRGeneA reliable method for random mutagenesis: the generation of mutant libraries using spiked oligodeoxyribonucleotide primers. Gene. 1989 Dec 07; 84(1):143-51.Gene1989-12-07T00:00:001989A reliable method for random mutagenesis: the generation of mutant libraries using spiked oligodeoxyribonucleotide primers.1883832Blacklow SC, Liu KD, Knowles JRBiochemistryStepwise improvements in catalytic effectiveness: independence and interdependence in combinations of point mutations of a sluggish triosephosphate isomerase. Biochemistry. 1991 Aug 27; 30(34):8470-6.Biochemistry1991-08-27T00:00:001991Stepwise improvements in catalytic effectiveness: independence and interdependence in combinations of point mutations of a sluggish triosephosphate isomerase.20805362Keeshan K, Bailis W, Dedhia PH, Vega ME, Shestova O, Xu L, Toscano K, Uljon SN, Blacklow SC, Pear WSBloodTransformation by Tribbles homolog 2 (Trib2) requires both the Trib2 kinase domain and COP1 binding. Blood. 2010 Dec 02; 116(23):4948-57.Blood2010-08-30T00:00:002010Transformation by Tribbles homolog 2 (Trib2) requires both the Trib2 kinase domain and COP1 binding.Authorship 102180220852131Ashworth TD, Pear WS, Chiang MY, Blacklow SC, Mastio J, Xu L, Kelliher M, Kastner P, Chan S, Aster JCBloodDeletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1. Blood. 2010 Dec 16; 116(25):5455-64.Blood2010-09-17T00:00:002010Deletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1.14500983Kim PW, Sun ZY, Blacklow SC, Wagner G, Eck MJScience (New York, N.Y.)A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8. Science. 2003 Sep 19; 301(5640):1725-8.Science2003-09-19T00:00:002003A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8.15114337Blacklow SCNature structural & molecular biologyCatching the common cold. Nat Struct Mol Biol. 2004 May; 11(5):388-90.Nat Struct Mol Biol2004-05-01T00:00:002004Catching the common cold.1967829Hermes JD, Blacklow SC, Knowles JRProceedings of the National Academy of Sciences of the United States of AmericaSearching sequence space by definably random mutagenesis: improving the catalytic potency of an enzyme. Proc Natl Acad Sci U S A. 1990 Jan; 87(2):696-700.Proc Natl Acad Sci U S A1990-01-01T00:00:001990Searching sequence space by definably random mutagenesis: improving the catalytic potency of an enzyme.18177055Estrada K, Fisher C, Blacklow SCBiochemistryUnfolding of the RAP-D3 helical bundle facilitates dissociation of RAP-receptor complexes. Biochemistry. 2008 Feb 12; 47(6):1532-9.Biochemistry2008-01-05T00:00:002008Unfolding of the RAP-D3 helical bundle facilitates dissociation of RAP-receptor complexes.11052664North CL, Blacklow SCBiochemistryEvidence that familial hypercholesterolemia mutations of the LDL receptor cause limited local misfolding in an LDL-A module pair. Biochemistry. 2000 Oct 31; 39(43):13127-35.Biochemistry2000-10-31T00:00:002000Evidence that familial hypercholesterolemia mutations of the LDL receptor cause limited local misfolding in an LDL-A module pair.22006338Wang NJ, Sanborn Z, Arnett KL, Bayston LJ, Liao W, Proby CM, Leigh IM, Collisson EA, Gordon PB, Jakkula L, Pennypacker S, Zou Y, Sharma M, North JP, Vemula SS, Mauro TM, Neuhaus IM, Leboit PE, Hur JS, Park K, Huh N, Kwok PY, Arron ST, Massion PP, Bale AE, Haussler D, Cleaver JE, Gray JW, Spellman PT, South AP, Aster JC, Blacklow SC, Cho RJProceedings of the National Academy of Sciences of the United States of AmericaLoss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma. Proc Natl Acad Sci U S A. 2011 Oct 25; 108(43):17761-6.Proc Natl Acad Sci U S A2011-10-17T00:00:002011Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma.22325781Choi SH, Wales TE, Nam Y, O'Donovan DJ, Sliz P, Engen JR, Blacklow SCStructure (London, England : 1993)Conformational locking upon cooperative assembly of notch transcription complexes. Structure. 2012 Feb 08; 20(2):340-9.Structure2012-02-08T00:00:002012Conformational locking upon cooperative assembly of notch transcription complexes.Authorship 1080822230030821Lovendahl KN, Blacklow SC, Gordon WRAdvances in experimental medicine and biologyThe Molecular Mechanism of Notch Activation. Adv Exp Med Biol. 2018; 1066:47-58.Adv Exp Med Biol2018-01-01T00:00:002018The Molecular Mechanism of Notch Activation.19075186Gordon WR, Roy M, Vardar-Ulu D, Garfinkel M, Mansour MR, Aster JC, Blacklow SCBloodStructure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL. Blood. 2009 Apr 30; 113(18):4381-90.Blood2008-12-15T00:00:002008Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL.Authorship 10885662530102854Wang J, Erazo T, Ferguson FM, Buckley DL, Gomez N, Muñoz-Guardiola P, Diéguez-Martínez N, Deng X, Hao M, Massefski W, Fedorov O, Offei-Addo NK, Park PM, Dai L, DiBona A, Becht K, Kim ND, McKeown MR, Roberts JM, Zhang J, Sim T, Alessi DR, Bradner JE, Lizcano JM, Blacklow SC, Qi J, Xu X, Gray NSACS chemical biologyStructural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and Bromodomains. ACS Chem Biol. 2018 09 21; 13(9):2438-2448.ACS Chem Biol2018-08-31T00:00:002018Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and Bromodomains.8133620Goldhaber SZ, Simons GR, Elliott CG, Haire WD, Toltzis R, Blacklow SC, Doolittle MH, Weinberg DSJAMAQuantitative plasma D-dimer levels among patients undergoing pulmonary angiography for suspected pulmonary embolism. JAMA. 1993 Dec 15; 270(23):2819-22.JAMA1993-12-15T00:00:001993Quantitative plasma D-dimer levels among patients undergoing pulmonary angiography for suspected pulmonary embolism.22349228O'Donovan DJ, Stokes-Rees I, Nam Y, Blacklow SC, Schröder GF, Brunger AT, Sliz PActa crystallographica. Section D, Biological crystallographyA grid-enabled web service for low-resolution crystal structure refinement. Acta Crystallogr D Biol Crystallogr. 2012 Mar; 68(Pt 3):261-7.Acta Crystallogr D Biol Crystallogr2012-02-14T00:00:002012A grid-enabled web service for low-resolution crystal structure refinement.3365378Blacklow SC, Raines RT, Lim WA, Zamore PD, Knowles JRBiochemistryTriosephosphate isomerase catalysis is diffusion controlled. Appendix: Analysis of triose phosphate equilibria in aqueous solution by 31P NMR. Biochemistry. 1988 Feb 23; 27(4):1158-67.Biochemistry1988-02-23T00:00:001988Triosephosphate isomerase catalysis is diffusion controlled. Appendix: Analysis of triose phosphate equilibria in aqueous solution by 31P NMR.20967796Aster JC, Blacklow SC, Pear WSThe Journal of pathologyNotch signalling in T-cell lymphoblastic leukaemia/lymphoma and other haematological malignancies. J Pathol. 2011 Jan; 223(2):262-73.J Pathol2010-10-21T00:00:002010Notch signalling in T-cell lymphoblastic leukaemia/lymphoma and other haematological malignancies.Authorship 1095956630289388Tveriakhina L, Schuster-Gossler K, Jarrett SM, Andrawes MB, Rohrbach M, Blacklow SC, Gossler AeLifeThe ectodomains determine ligand function in vivo and selectivity of DLL1 and DLL4 toward NOTCH1 and NOTCH2 in vitro. Elife. 2018 10 05; 7.Elife2018-10-05T00:00:002018The ectodomains determine ligand function in vivo and selectivity of DLL1 and DLL4 toward NOTCH1 and NOTCH2 in vitro.17870468Blacklow SCCurrent opinion in structural biologyVersatility in ligand recognition by LDL receptor family proteins: advances and frontiers. Curr Opin Struct Biol. 2007 Aug; 17(4):419-26.Curr Opin Struct Biol2007-09-17T00:00:002007Versatility in ligand recognition by LDL receptor family proteins: advances and frontiers.Authorship 11100651030375388LaRochelle JR, Fodor M, Vemulapalli V, Mohseni M, Wang P, Stams T, LaMarche MJ, Chopra R, Acker MG, Blacklow SCNature communicationsStructural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition. Nat Commun. 2018 10 30; 9(1):4508.Nat Commun2018-10-30T00:00:002018Structural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition.Authorship 131018298623651Appignani BA, Bhadelia RA, Blacklow SC, Wang AK, Roland SF, Freeman RBAJR. American journal of roentgenologyNeuroimaging findings in patients on immunosuppressive therapy: experience with tacrolimus toxicity. AJR Am J Roentgenol. 1996 Mar; 166(3):683-8.AJR Am J Roentgenol1996-03-01T00:00:001996Neuroimaging findings in patients on immunosuppressive therapy: experience with tacrolimus toxicity.RC265RuiliCaoRuili Cao, Ph.D.176163Cao, RuiliResearch Associate in Biological Chemistry and Molecular Pharmacology15450813Forster AC, Cornish VW, Blacklow SCAnalytical biochemistryPure translation display. Anal Biochem. 2004 Oct 15; 333(2):358-64.Anal Biochem2004-10-15T00:00:002004Pure translation display.20935071Liu H, Chi AW, Arnett KL, Chiang MY, Xu L, Shestova O, Wang H, Li YM, Bhandoola A, Aster JC, Blacklow SC, Pear WSGenes & developmentNotch dimerization is required for leukemogenesis and T-cell development. Genes Dev. 2010 Nov 01; 24(21):2395-407.Genes Dev2010-10-08T00:00:002010Notch dimerization is required for leukemogenesis and T-cell development.22109558Germar K, Dose M, Konstantinou T, Zhang J, Wang H, Lobry C, Arnett KL, Blacklow SC, Aifantis I, Aster JC, Gounari FProceedings of the National Academy of Sciences of the United States of AmericaT-cell factor 1 is a gatekeeper for T-cell specification in response to Notch signaling. Proc Natl Acad Sci U S A. 2011 Dec 13; 108(50):20060-5.Proc Natl Acad Sci U S A2011-11-22T00:00:002011T-cell factor 1 is a gatekeeper for T-cell specification in response to Notch signaling.7578108Blacklow SC, Lu M, Kim PSBiochemistryA trimeric subdomain of the simian immunodeficiency virus envelope glycoprotein. Biochemistry. 1995 Nov 21; 34(46):14955-62.Biochemistry1995-11-21T00:00:001995A trimeric subdomain of the simian immunodeficiency virus envelope glycoprotein.Authorship 1158646Authorship 11321841130745086Petrovic J, Zhou Y, Fasolino M, Goldman N, Schwartz GW, Mumbach MR, Nguyen SC, Rome KS, Sela Y, Zapataro Z, Blacklow SC, Kruhlak MJ, Shi J, Aster JC, Joyce EF, Little SC, Vahedi G, Pear WS, Faryabi RBMolecular cellOncogenic Notch Promotes Long-Range Regulatory Interactions within Hyperconnected 3D Cliques. Mol Cell. 2019 03 21; 73(6):1174-1190.e12.Mol Cell2019-02-07T00:00:002019Oncogenic Notch Promotes Long-Range Regulatory Interactions within Hyperconnected 3D Cliques.Authorship 1134910630826165Rogers JM, Waters CT, Seegar TCM, Jarrett SM, Hallworth AN, Blacklow SC, Bulyk MLMolecular cellBispecific Forkhead Transcription Factor FoxN3 Recognizes Two Distinct Motifs with Different DNA Shapes. Mol Cell. 2019 04 18; 74(2):245-253.e6.Mol Cell2019-02-27T00:00:002019Bispecific Forkhead Transcription Factor FoxN3 Recognizes Two Distinct Motifs with Different DNA Shapes.D054592Chemicals & Drugs1482340.891886Protein Tyrosine Phosphatase, Non-Receptor Type 11D051819Chemicals & Drugs541210.939142Immunoglobulin J Recombination Signal Sequence-Binding ProteinAuthorship 1146919330946563Drabek AA, Loparo JJ, Blacklow SCBiochemistryA Flow-Extension Tethered Particle Motion Assay for Single-Molecule Proteolysis. Biochemistry. 2019 05 21; 58(20):2509-2518.Biochemistry2019-04-12T00:00:002019A Flow-Extension Tethered Particle Motion Assay for Single-Molecule Proteolysis.D011973Chemicals & Drugs2514720.803748Receptors, LDLD051880Chemicals & Drugs3517370.683318Receptors, NotchAuthorship 1244986D051881Chemicals & Drugs2435010.768759Receptor, Notch1Cell BiologyDermatologyEmeritusGeneticsPathologyBrigham and Women's HospitalBoston Children's HospitalHarvard Medical SchoolSAM22StevenMcCarrollSteven A. McCarroll, Ph.D.42.33837200000000-71.1032690000000079984McCarroll, StevenDorothy and Milton Flier Professor of Biomedical Science and GeneticsDH7DavidHaflerDavid A. Hafler, M.D.42.33837200000000-71.1032690000000082929Hafler, DavidJack, Sadie and David Breakstone Professor of Neurology, EmeritusTAS3TimothySpringerTimothy Alan Springer, Ph.D.42.33849900000000-71.1044600000000014719Springer, TimothyLatham Family Professor of Biological Chemistry and Molecular PharmacologySB134StevenBarthelSteven Barthel, Ph.D.42.33837200000000-71.1032690000000055463Barthel, StevenAssistant Professor of DermatologySPG4StevenGygiSteven P. Gygi, Ph.D.42.33588600000000-71.1051460000000028969Gygi, StevenProfessor of Cell BiologySA12SpyrosArtavanis-TsakonasSpyros Artavanis-Tsakonas, Ph.D.42.33588600000000-71.1051460000000051311Artavanis-Tsakonas, SpyrosLecturer on Cell Biology, Part-timeMBF1MelFeanyMel B. Feany, M.D., Ph.D.42.33837200000000-71.1032690000000044560Feany, MelProfessor of Pathology11162selected publications8.108720.00131739545research areas4.708360.0089317372coauthor of109.72621.58860similar toNP7NorbertPerrimonNorbert Perrimon, Ph.D.42.33837200000000-71.103269000000006247Perrimon, NorbertJames Stillman Professor of Developmental BiologyJCA4JonAsterJon Christopher Aster, M.D.,Ph.D.42.33480000000000-71.1043000000000048586Aster, JonRamzi S. Cotran Professor of PathologyAuthorship 1326524KLA4KellyArnettKelly Arnett, Ph.D.42.33837200000000-71.1032690000000011095Arnett, KellyLecturer on Biological Chemistry and Molecular PharmacologyAuthorship 1175598231333048Seegar TC, Blacklow SCExperimental biology and medicine (Maywood, N.J.)Domain integration of ADAM family proteins: Emerging themes from structural studies. Exp Biol Med (Maywood). 2019 12; 244(17):1510-1519.Exp Biol Med (Maywood)2019-07-23T00:00:002019Domain integration of ADAM family proteins: Emerging themes from structural studies.Authorship 1635487Authorship 1203236731690634Jarrett SM, Seegar TCM, Andrews M, Adelmant G, Marto JA, Aster JC, Blacklow SCScience signalingExtension of the Notch intracellular domain ankyrin repeat stack by NRARP promotes feedback inhibition of Notch signaling. Sci Signal. 2019 11 05; 12(606).Sci Signal2019-11-05T00:00:002019Extension of the Notch intracellular domain ankyrin repeat stack by NRARP promotes feedback inhibition of Notch signaling.true1Dorothy and Milton Flier Professor of Biomedical Science and GeneticsDorothy and Milton Flier Professor of Biomedical Science and Geneticstrue1Jack, Sadie and David Breakstone Professor of Neurology, EmeritusJack, Sadie and David Breakstone Professor of Neurology, Emeritustrue1James Stillman Professor of Developmental BiologyJames Stillman Professor of Developmental Biologytrue1Professor of PathologyProfessor of PathologyAuthorship 1254572Authorship 1359846Authorship 130536Authorship 15913Authorship 12265801132042200Adhikari AA, Seegar TCM, Ficarro SB, McCurry MD, Ramachandran D, Yao L, Chaudhari SN, Ndousse-Fetter S, Banks AS, Marto JA, Blacklow SC, Devlin ASNature chemical biologyDevelopment of a covalent inhibitor of gut bacterial bile salt hydrolases. Nat Chem Biol. 2020 03; 16(3):318-326.Nat Chem Biol2020-02-10T00:00:002020Development of a covalent inhibitor of gut bacterial bile salt hydrolases.LT149LenaTveriakhinaLena Tveriakhina, Ph.D.187770Tveriakhina, LenaResearch Associate in Biological Chemistry and Molecular PharmacologyAuthorship 12324906Authorship 12325141332150623Rome KS, Stein SJ, Kurachi M, Petrovic J, Schwartz GW, Mack EA, Uljon S, Wu WW, DeHart AG, McClory SE, Xu L, Gimotty PA, Blacklow SC, Faryabi RB, Wherry EJ, Jordan MS, Pear WSThe Journal of experimental medicineTrib1 regulates T cell differentiation during chronic infection by restraining the effector program. J Exp Med. 2020 05 04; 217(5).J Exp Med2020-05-04T00:00:002020Trib1 regulates T cell differentiation during chronic infection by restraining the effector program.32179552Rogers JM, Guo B, Egan ED, Aster JC, Adelman K, Blacklow SCMolecular and cellular biologyMAML1-Dependent Notch-Responsive Genes Exhibit Differing Cofactor Requirements for Transcriptional Activation. Mol Cell Biol. 2020 05 14; 40(11).Mol Cell Biol2020-05-14T00:00:002020MAML1-Dependent Notch-Responsive Genes Exhibit Differing Cofactor Requirements for Transcriptional Activation.Authorship 173756Authorship 1244158332338599Susa KJ, Seegar TC, Blacklow SC, Kruse ACeLifeA dynamic interaction between CD19 and the tetraspanin CD81 controls B cell co-receptor trafficking. Elife. 2020 04 27; 9.Elife2020-04-27T00:00:002020A dynamic interaction between CD19 and the tetraspanin CD81 controls B cell co-receptor trafficking.Authorship 12611351332601208Lehal R, Zaric J, Vigolo M, Urech C, Frismantas V, Zangger N, Cao L, Berger A, Chicote I, Loubéry S, Choi SH, Koch U, Blacklow SC, Palmer HG, Bornhauser B, González-Gaitán M, Arsenijevic Y, Zoete V, Aster JC, Bourquin JP, Radtke FProceedings of the National Academy of Sciences of the United States of AmericaPharmacological disruption of the Notch transcription factor complex. Proc Natl Acad Sci U S A. 2020 07 14; 117(28):16292-16301.Proc Natl Acad Sci U S A2020-06-29T00:00:002020Pharmacological disruption of the Notch transcription factor complex.Authorship 1595233Authorship 1616395Authorship 1604512Authorship 1861077true1Professor of Cell BiologyProfessor of Cell Biologytrue1Professor of Biological Chemistry and Molecular PharmacologyProfessor of Biological Chemistry and Molecular PharmacologyBCMPAuthorship 12883561232936072Pan L, Lemieux ME, Thomas T, Rogers JM, Lipper CH, Lee W, Johnson C, Sholl LM, South AP, Marto JA, Adelmant GO, Blacklow SC, Aster JCeLifeIER5, a DNA damage response gene, is required for Notch-mediated induction of squamous cell differentiation. Elife. 2020 09 16; 9.Elife2020-09-16T00:00:002020IER5, a DNA damage response gene, is required for Notch-mediated induction of squamous cell differentiation.Authorship 1963443Authorship 153018133278894Feng R, Wang Y, Ramachandran V, Ma Q, May MM, Li M, Zhou JX, Xu X, Xu K, Fang S, Xia W, Sui D, Liu H, Gao X, Prieto V, Blacklow SC, Lu M, Lee JEJournal of experimental & clinical cancer research : CRCharacterization of novel neutralizing mouse monoclonal antibody JM1-24-3 developed against MUC18 in metastatic melanoma. J Exp Clin Cancer Res. 2020 Dec 05; 39(1):273.J Exp Clin Cancer Res2020-12-05T00:00:002020Characterization of novel neutralizing mouse monoclonal antibody JM1-24-3 developed against MUC18 in metastatic melanoma.Authorship 131336816Authorship 131721013Authorship 1316641533408408Ben-Sasson AJ, Watson JL, Sheffler W, Johnson MC, Bittleston A, Somasundaram L, Decarreau J, Jiao F, Chen J, Mela I, Drabek AA, Jarrett SM, Blacklow SC, Kaminski CF, Hura GL, De Yoreo JJ, Kollman JM, Ruohola-Baker H, Derivery E, Baker DNatureDesign of biologically active binary protein 2D materials. Nature. 2021 01; 589(7842):468-473.Nature2021-01-06T00:00:002021Design of biologically active binary protein 2D materials.33416860Watson JL, Aich S, Oller-Salvia B, Drabek AA, Blacklow SC, Chin J, Derivery EThe Journal of cell biologyHigh-efficacy subcellular micropatterning of proteins using fibrinogen anchors. J Cell Biol. 2021 02 01; 220(2).J Cell Biol2021-02-01T00:00:002021High-efficacy subcellular micropatterning of proteins using fibrinogen anchors.Authorship 1322683433446559Susa KJ, Rawson S, Kruse AC, Blacklow SCScience (New York, N.Y.)Cryo-EM structure of the B cell co-receptor CD19 bound to the tetraspanin CD81. Science. 2021 01 15; 371(6526):300-305.Science2021-01-15T00:00:002021Cryo-EM structure of the B cell co-receptor CD19 bound to the tetraspanin CD81.Authorship 1325786233534608Sprinzak D, Blacklow SCAnnual review of biophysicsBiophysics of Notch Signaling. Annu Rev Biophys. 2021 05 06; 50:157-189.Annu Rev Biophys2021-02-03T00:00:002021Biophysics of Notch Signaling.Authorship 13356171333654323Ben-Sasson AJ, Watson JL, Sheffler W, Johnson MC, Bittleston A, Somasundaram L, Decarreau J, Jiao F, Chen J, Mela I, Drabek AA, Jarrett SM, Blacklow SC, Kaminski CF, Hura GL, De Yoreo JJ, Kollman JM, Ruohola-Baker H, Derivery E, Baker DNatureAuthor Correction: Design of biologically active binary protein 2D materials. Nature. 2021 Mar; 591(7850):E16.Nature2021-03-01T00:00:002021Author Correction: Design of biologically active binary protein 2D materials.Authorship 13413531533755016Vemulapalli V, Chylek LA, Erickson A, Pfeiffer A, Gabriel KH, LaRochelle J, Subramanian K, Cao R, Stegmaier K, Mohseni M, LaMarche MJ, Acker MG, Sorger PK, Gygi SP, Blacklow SCeLifeTime-resolved phosphoproteomics reveals scaffolding and catalysis-responsive patterns of SHP2-dependent signaling. Elife. 2021 03 23; 10.Elife2021-03-23T00:00:002021Time-resolved phosphoproteomics reveals scaffolding and catalysis-responsive patterns of SHP2-dependent signaling.Authorship 1557823Authorship 13860691234411482Vemulapalli V, Donovan KA, Seegar TCM, Rogers JM, Bae M, Lumpkin RJ, Cao R, Henke MT, Ray SS, Fischer ES, Cuny GD, Blacklow SCBiochemistryTargeted Degradation of the Oncogenic Phosphatase SHP2. Biochemistry. 2021 08 31; 60(34):2593-2609.Biochemistry2021-08-19T00:00:002021Targeted Degradation of the Oncogenic Phosphatase SHP2.Authorship 1411834634739841Lipper CH, Gabriel KH, Seegar TCM, Dürr KL, Tomlinson MG, Blacklow SCStructure (London, England : 1993)Crystal structure of the Tspan15 LEL domain reveals a conserved ADAM10 binding site. Structure. 2022 02 03; 30(2):206-214.e4.Structure2021-11-04T00:00:002021Crystal structure of the Tspan15 LEL domain reveals a conserved ADAM10 binding site.Authorship 1913944Authorship 14399162Authorship 1442540735284598Vemulapalli V, Blacklow SC, Gygi SP, Erickson ABio-protocolEnrichment of Tyrosine Phosphorylated Peptides for Quantitative Mass Spectrometry Analysis of RTK Signaling Dynamics. Bio Protoc. 2022 Feb 05; 12(3):e4311.Bio Protoc2022-02-05T00:00:002022Enrichment of Tyrosine Phosphorylated Peptides for Quantitative Mass Spectrometry Analysis of RTK Signaling Dynamics.35311954Pfeiffer A, Franciosa G, Locard-Paulet M, Piga I, Reckzeh K, Vemulapalli V, Blacklow SC, Theilgaard-Mönch K, Jensen LJ, Olsen JVCancer researchPhosphorylation of SHP2 at Tyr62 Enables Acquired Resistance to SHP2 Allosteric Inhibitors in FLT3-ITD-Driven AML. Cancer Res. 2022 06 06; 82(11):2141-2155.Cancer Res2022-06-06T00:00:002022Phosphorylation of SHP2 at Tyr62 Enables Acquired Resistance to SHP2 Allosteric Inhibitors in FLT3-ITD-Driven AML.Authorship 35648410true1Ramzi S. Cotran Professor of PathologyRamzi S. Cotran Professor of PathologyAuthorship 14831883Authorship 1497046936050494Gonzalez-Perez D, Das S, Antfolk D, Ahsan HS, Medina E, Dundes CE, Jokhai RT, Egan ED, Blacklow SC, Loh KM, Rodriguez PC, Luca VCNature chemical biologyAffinity-matured DLL4 ligands as broad-spectrum modulators of Notch signaling. Nat Chem Biol. 2023 01; 19(1):9-17.Nat Chem Biol2022-09-01T00:00:002022Affinity-matured DLL4 ligands as broad-spectrum modulators of Notch signaling.36107643Khamaisi B, Luca VC, Blacklow SC, Sprinzak DACS synthetic biologyFunctional Comparison between Endogenous and Synthetic Notch Systems. ACS Synth Biol. 2022 10 21; 11(10):3343-3353.ACS Synth Biol2022-09-15T00:00:002022Functional Comparison between Endogenous and Synthetic Notch Systems.true1Assistant Professor of DermatologyAssistant Professor of DermatologyAuthorship 199513Authorship 156798630Authorship 15675336Authorship 1553137637405741Tessler I, Albuisson J, Piñeiro-Sabarís R, Verstraeten A, Kamber Kaya HE, Siguero-Álvarez M, Goudot G, MacGrogan D, Luyckx I, Shpitzen S, Levin G, Kelman G, Reshef N, Mananet H, Holdcraft J, Muehlschlegel JD, Peloso GM, Oppenheim O, Cheng C, Mazzella JM, Andelfinger G, Mital S, Eriksson P, Billon C, Heydarpour M, Dietz HC, Jeunemaitre X, Leitersdorf E, Sprinzak D, Blacklow SC, Body SC, Carmi S, Loeys B, de la Pompa JL, Gilon D, Messas E, Durst RJAMA cardiologyNovel Association of the NOTCH Pathway Regulator MIB1 Gene With the Development of Bicuspid Aortic Valve. JAMA Cardiol. 2023 08 01; 8(8):721-731.JAMA Cardiol2023-08-01T00:00:002023Novel Association of the NOTCH Pathway Regulator MIB1 Gene With the Development of Bicuspid Aortic Valve.36993395Susa KJ, Bradshaw GA, Eisert RJ, Schilling CM, Kalocsay M, Blacklow SC, Kruse ACbioRxiv : the preprint server for biologyA Spatiotemporal Map of Co-Receptor Signaling Networks Underlying B Cell Activation. bioRxiv. 2023 Mar 21.bioRxiv2023-03-21T00:00:002023A Spatiotemporal Map of Co-Receptor Signaling Networks Underlying B Cell Activation.37120430Jones DTD, Dates AN, Rawson SD, Burruss MM, Lipper CH, Blacklow SCNature communicationsTethered agonist activated ADGRF1 structure and signalling analysis reveal basis for G protein coupling. Nat Commun. 2023 04 29; 14(1):2490.Nat Commun2023-04-29T00:00:002023Tethered agonist activated ADGRF1 structure and signalling analysis reveal basis for G protein coupling.Authorship 15829654Authorship 158369412Authorship 1587376737516108Lipper CH, Egan ED, Gabriel KH, Blacklow SCCellStructural basis for membrane-proximal proteolysis of substrates by ADAM10. Cell. 2023 08 17; 186(17):3632-3641.e10.Cell2023-07-28T00:00:002023Structural basis for membrane-proximal proteolysis of substrates by ADAM10.37527352Martin AP, Bradshaw GA, Eisert RJ, Egan ED, Tveriakhina L, Rogers JM, Dates AN, Scanavachi G, Aster JC, Kirchhausen T, Kalocsay M, Blacklow SCScience signalingA spatiotemporal Notch interaction map from plasma membrane to nucleus. Sci Signal. 2023 08; 16(796):eadg6474.Sci Signal2023-08-01T00:00:002023A spatiotemporal Notch interaction map from plasma membrane to nucleus.37693604Cao R, Jones DT, Pan L, Wang S, Rawson S, Aster JC, Blacklow SCbioRxiv : the preprint server for biologyMolecular Mechanism of PP2A/B55a Inhibition by IER5. bioRxiv. 2023 Aug 29.bioRxiv2023-08-29T00:00:002023Molecular Mechanism of PP2A/B55a Inhibition by IER5.Authorship 1594955337783654Susa KJ, Kruse AC, Blacklow SCTrends in cell biologyTetraspanins: structure, dynamics, and principles of partner-protein recognition. Trends Cell Biol. 2023 Sep 30.Trends Cell Biol2023-09-30T00:00:002023Tetraspanins: structure, dynamics, and principles of partner-protein recognition.Authorship 15967141037808809Tveriakhina L, Scanavachi G, Egan ED, Correia RBDC, Martin AP, Rogers JM, Yodh JS, Aster JC, Kirchhausen T, Blacklow SCbioRxiv : the preprint server for biologyTemporal Dynamics and Stoichiometry in Notch Signaling - from Notch Synaptic Complex Formation to NICD Nuclear Entry. bioRxiv. 2023 Sep 28.bioRxiv2023-09-28T00:00:002023Temporal Dynamics and Stoichiometry in Notch Signaling - from Notch Synaptic Complex Formation to NICD Nuclear Entry.2Head of the Department of Biological Chemistry and Molecular PharmacologyHead of the Department of Biological Chemistry and Molecular Pharmacologytrue1Gustavus Adolphus Pfeiffer Professor of Biological Chemistry and Molecular PharmacologyGustavus Adolphus Pfeiffer Professor of Biological Chemistry and Molecular Pharmacologytrue1Lecturer on Cell Biology, Part-timeLecturer on Cell Biology, Part-timeAuthorship 1765314true1Research Associate in Biological Chemistry and Molecular PharmacologyResearch Associate in Biological Chemistry and Molecular Pharmacologytrue1Research Associate in Biological Chemistry and Molecular PharmacologyResearch Associate in Biological Chemistry and Molecular PharmacologyAuthorship 5473872true1Lecturer on Biological Chemistry and Molecular PharmacologyLecturer on Biological Chemistry and Molecular PharmacologyAuthorship 2155052true1Latham Family Professor of Biological Chemistry and Molecular PharmacologyLatham Family Professor of Biological Chemistry and Molecular PharmacologyAuthorship 5708894Authorship 3124503Authorship 646249523747483Tiyanont K, Wales TE, Siebel CW, Engen JR, Blacklow SCJournal of molecular biologyInsights into Notch3 activation and inhibition mediated by antibodies directed against its negative regulatory region. J Mol Biol. 2013 Sep 09; 425(17):3192-204.J Mol Biol2013-06-06T00:00:002013Insights into Notch3 activation and inhibition mediated by antibodies directed against its negative regulatory region.Authorship 1818451Authorship 1964752Authorship 2024943Authorship 6752827Authorship 675947323839946Andrawes MB, Xu X, Liu H, Ficarro SB, Marto JA, Aster JC, Blacklow SCThe Journal of biological chemistryIntrinsic selectivity of Notch 1 for Delta-like 4 over Delta-like 1. J Biol Chem. 2013 Aug 30; 288(35):25477-25489.J Biol Chem2013-07-09T00:00:002013Intrinsic selectivity of Notch 1 for Delta-like 4 over Delta-like 1.23893350Wittinghofer A, Martin JB, Blacklow SBiopolymersProteins special issue of biopolymers. Biopolymers. 2013 Nov; 99(11):807-8.Biopolymers2013-11-01T00:00:002013Proteins special issue of biopolymers.Authorship 3545001Authorship 1766138Authorship 697624124315457Blacklow SCStructure (London, England : 1993)Refining a Jagged edge. Structure. 2013 Dec 03; 21(12):2100-1.Structure2013-12-03T00:00:002013Refining a Jagged edge.Authorship 3881373Authorship 704070724374627Wang H, Zang C, Taing L, Arnett KL, Wong YJ, Pear WS, Blacklow SC, Liu XS, Aster JCProceedings of the National Academy of Sciences of the United States of AmericaNOTCH1-RBPJ complexes drive target gene expression through dynamic interactions with superenhancers. Proc Natl Acad Sci U S A. 2014 Jan 14; 111(2):705-10.Proc Natl Acad Sci U S A2013-12-27T00:00:002013NOTCH1-RBPJ complexes drive target gene expression through dynamic interactions with superenhancers.Authorship 2332533Authorship 24656332Authorship 3061474Authorship 4470283AK432AndrewKruseAndrew Kruse, Ph.D.126760Kruse, AndrewProfessor of Biological Chemistry and Molecular PharmacologyAuthorship 2688172Authorship 4193427Authorship 750667225053494Arnett KL, Blacklow SCMethods in molecular biology (Clifton, N.J.)Analyzing the nuclear complexes of Notch signaling by electrophoretic mobility shift assay. Methods Mol Biol. 2014; 1187:231-45.Methods Mol Biol2014-01-01T00:00:002014Analyzing the nuclear complexes of Notch signaling by electrophoretic mobility shift assay.Authorship 5591219Authorship 5619592Authorship 568962Authorship 3945772Authorship 42972910Authorship 895732Authorship 7692891225314271McKeown MR, Shaw DL, Fu H, Liu S, Xu X, Marineau JJ, Huang Y, Zhang X, Buckley DL, Kadam A, Zhang Z, Blacklow SC, Qi J, Zhang W, Bradner JEJournal of medicinal chemistryBiased multicomponent reactions to develop novel bromodomain inhibitors. J Med Chem. 2014 Nov 13; 57(21):9019-27.J Med Chem2014-10-31T00:00:002014Biased multicomponent reactions to develop novel bromodomain inhibitors.Authorship 7715141725369933Yashiro-Ohtani Y, Wang H, Zang C, Arnett KL, Bailis W, Ho Y, Knoechel B, Lanauze C, Louis L, Forsyth KS, Chen S, Chung Y, Schug J, Blobel GA, Liebhaber SA, Bernstein BE, Blacklow SC, Liu XS, Aster JC, Pear WSProceedings of the National Academy of Sciences of the United States of AmericaLong-range enhancer activity determines Myc sensitivity to Notch inhibitors in T cell leukemia. Proc Natl Acad Sci U S A. 2014 Nov 18; 111(46):E4946-53.Proc Natl Acad Sci U S A2014-11-04T00:00:002014Long-range enhancer activity determines Myc sensitivity to Notch inhibitors in T cell leukemia.Authorship 4618324Authorship 56441Authorship 4007113Authorship 4045866Authorship 872710Authorship 3948577Authorship 4067281Authorship 4414527Authorship 44937115Authorship 3513052Authorship 1694365Authorship 52590415Authorship 17824311Authorship 4879051Authorship 5703963Authorship 657423Authorship 884919Authorship 1116175Authorship 2527462Authorship 4097377Authorship 42415Authorship 2401814Authorship 3623304Authorship 37795911Authorship 4147933Authorship 7914135Authorship 801103825747658McMillan BJ, Schnute B, Ohlenhard N, Zimmerman B, Miles L, Beglova N, Klein T, Blacklow SCMolecular cellA tail of two sites: a bipartite mechanism for recognition of notch ligands by mind bomb E3 ligases. Mol Cell. 2015 Mar 05; 57(5):912-924.Mol Cell2015-03-05T00:00:002015A tail of two sites: a bipartite mechanism for recognition of notch ligands by mind bomb E3 ligases.25918160Habets RA, Groot AJ, Yahyanejad S, Tiyanont K, Blacklow SC, Vooijs MThe Journal of biological chemistryHuman NOTCH2 Is Resistant to Ligand-independent Activation by Metalloprotease Adam17. J Biol Chem. 2015 Jun 05; 290(23):14705-16.J Biol Chem2015-04-27T00:00:002015Human NOTCH2 Is Resistant to Ligand-independent Activation by Metalloprotease Adam17.Authorship 4546805Authorship 4791333Authorship 536512Authorship 5666429Authorship 8123921126051539Gordon WR, Zimmerman B, He L, Miles LJ, Huang J, Tiyanont K, McArthur DG, Aster JC, Perrimon N, Loparo JJ, Blacklow SCDevelopmental cellMechanical Allostery: Evidence for a Force Requirement in the Proteolytic Activation of Notch. Dev Cell. 2015 Jun 22; 33(6):729-36.Dev Cell2015-06-04T00:00:002015Mechanical Allostery: Evidence for a Force Requirement in the Proteolytic Activation of Notch.Authorship 8150471126051713Xu X, Choi SH, Hu T, Tiyanont K, Habets R, Groot AJ, Vooijs M, Aster JC, Chopra R, Fryer C, Blacklow SCStructure (London, England : 1993)Insights into Autoregulation of Notch3 from Structural and Functional Studies of Its Negative Regulatory Region. Structure. 2015 Jul 07; 23(7):1227-35.Structure2015-06-04T00:00:002015Insights into Autoregulation of Notch3 from Structural and Functional Studies of Its Negative Regulatory Region.Authorship 3832086Authorship 519902Authorship 40824511Authorship 5032333Authorship 5332113Authorship 5411922Authorship 5414292Authorship 8681921426947396Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, Bonvin AM, Borek D, Brett TJ, Caflisch A, Chang CI, Chazin WJ, Corbett KD, Cosgrove MS, Crosson S, Dhe-Paganon S, Di Cera E, Drennan CL, Eck MJ, Eichman BF, Fan QR, Ferré-D'Amaré AR, Fromme JC, Garcia KC, Gaudet R, Gong P, Harrison SC, Heldwein EE, Jia Z, Keenan RJ, Kruse AC, Kvansakul M, McLellan JS, Modis Y, Nam Y, Otwinowski Z, Pai EF, Pereira PJ, Petosa C, Raman CS, Rapoport TA, Roll-Mecak A, Rosen MK, Rudenko G, Schlessinger J, Schwartz TU, Shamoo Y, Sondermann H, Tao YJ, Tolia NH, Tsodikov OV, Westover KD, Wu H, Foster I, Fraser JS, Maia FR, Gonen T, Kirchhausen T, Diederichs K, Crosas M, Sliz PNature communicationsData publication with the structural biology data grid supports live analysis. Nat Commun. 2016 Mar 07; 7:10882.Nat Commun2016-03-07T00:00:002016Data publication with the structural biology data grid supports live analysis.Authorship 699272Authorship 8775171327030275LaRochelle JR, Fodor M, Xu X, Durzynska I, Fan L, Stams T, Chan HM, LaMarche MJ, Chopra R, Wang P, Fortin PD, Acker MG, Blacklow SCBiochemistryStructural and Functional Consequences of Three Cancer-Associated Mutations of the Oncogenic Phosphatase SHP2. Biochemistry. 2016 Apr 19; 55(15):2269-77.Biochemistry2016-04-11T00:00:002016Structural and Functional Consequences of Three Cancer-Associated Mutations of the Oncogenic Phosphatase SHP2.Authorship 8802848Authorship 8804031327148573Knoechel B, Bhatt A, Pan L, Pedamallu CS, Severson E, Gutierrez A, Dorfman DM, Kuo FC, Kluk M, Kung AL, Zweidler-McKay P, Meyerson M, Blacklow SC, DeAngelo DJ, Aster JCCold Spring Harbor molecular case studiesComplete hematologic response of early T-cell progenitor acute lymphoblastic leukemia to the ?-secretase inhibitor BMS-906024: genetic and epigenetic findings in an outlier case. Cold Spring Harb Mol Case Stud. 2015 Oct; 1(1):a000539.Cold Spring Harb Mol Case Stud2015-10-01T00:00:002015Complete hematologic response of early T-cell progenitor acute lymphoblastic leukemia to the ?-secretase inhibitor BMS-906024: genetic and epigenetic findings in an outlier case.27041596Uljon S, Xu X, Durzynska I, Stein S, Adelmant G, Marto JA, Pear WS, Blacklow SCStructure (London, England : 1993)Structural Basis for Substrate Selectivity of the E3 Ligase COP1. Structure. 2016 05 03; 24(5):687-696.Structure2016-03-31T00:00:002016Structural Basis for Substrate Selectivity of the E3 Ligase COP1.Authorship 5198531Authorship 5682195Authorship 5552352Authorship 56217632Assistant Professor0Full Professor3Lecturer5Other FacultyAuthorship 895942627452459McMillan BJ, Tibbe C, Jeon H, Drabek AA, Klein T, Blacklow SCCell reportsElectrostatic Interactions between Elongated Monomers Drive Filamentation of Drosophila Shrub, a Metazoan ESCRT-III Protein. Cell Rep. 2016 08 02; 16(5):1211-1217.Cell Rep2016-07-21T00:00:002016Electrostatic Interactions between Elongated Monomers Drive Filamentation of Drosophila Shrub, a Metazoan ESCRT-III Protein.2008-03-31BLACKLOW, STEPHEN C.1998-02-01Structure and Function of the LDL ReceptorR01HL0610012013-06-30SWEET, ROBERT M1998-09-30Macromolecular Crystallography at the National Synchrotron Light SourceP41RR0124082022-06-30WALENSKY, LOREN DAVID1979-07-01Medical Scientist Training ProgramT32GM0077532019-08-31BLACKLOW, STEPHEN C.2001-07-01Structure and function in Notch SignalingR01CA0924332006-08-31BLACKLOW, STEPHEN C.2006-04-01Oncogenic Notch Signaling: Structural StudiesR01CA1191302004-04-30GRIFFIN, ROBERT GUY1976-05-01CENTER FOR MAGNETIC RESONANCEP41RR0009952018-06-30ASTER, JON C.2005-12-01Oncogenic Notch SignalingP01CA1190702015-04-30BLACKLOW, STEPHEN C.2014-05-102014 Notch Signaling in Development & Disease Gordon Research Conference/SeminarR13HD0802972019-11-30SORGER, PETER KARL2014-09-01The HMS Laboratory of Systems PharmacologyP50GM1076182017-04-30BLACKLOW, STEPHEN C.2016-05-102016 Notch Gordon Research Conference & Gordon Research SeminarR13HD0880002009-06-30BLACKLOW, STEPHEN C.2001-07-01Structure and Function in Notch SignalingR56CA092433Co-Principal InvestigatorPrincipal InvestigatorCo-Principal InvestigatorCo-Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorCo-Principal InvestigatorPrincipal InvestigatorCo-Principal InvestigatorAuthorship 609633Authorship 5015454Authorship 5221157Authorship 9338523Authorship 9348522627285058Guo B, McMillan BJ, Blacklow SCCurrent opinion in structural biologyStructure and function of the Mind bomb E3 ligase in the context of Notch signal transduction. Curr Opin Struct Biol. 2016 12; 41:38-45.Curr Opin Struct Biol2016-06-07T00:00:002016Structure and function of the Mind bomb E3 ligase in the context of Notch signal transduction.27157619Bernasconi-Elias P, Hu T, Jenkins D, Firestone B, Gans S, Kurth E, Capodieci P, Deplazes-Lauber J, Petropoulos K, Thiel P, Ponsel D, Hee Choi S, LeMotte P, London A, Goetcshkes M, Nolin E, Jones MD, Slocum K, Kluk MJ, Weinstock DM, Christodoulou A, Weinberg O, Jaehrling J, Ettenberg SA, Buckler A, Blacklow SC, Aster JC, Fryer CJOncogeneCharacterization of activating mutations of NOTCH3 in T-cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies. Oncogene. 2016 11 24; 35(47):6077-6086.Oncogene2016-05-09T00:00:002016Characterization of activating mutations of NOTCH3 in T-cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies.Authorship 951497Authorship 937944727881302Zimmerman B, Kelly B, McMillan BJ, Seegar TCM, Dror RO, Kruse AC, Blacklow SCCellCrystal Structure of a Full-Length Human Tetraspanin Reveals a Cholesterol-Binding Pocket. Cell. 2016 11 03; 167(4):1041-1051.e11.Cell2016-10-27T00:00:002016Crystal Structure of a Full-Length Human Tetraspanin Reveals a Cholesterol-Binding Pocket.Authorship 3082799Authorship 3150866Authorship 940675327959635Aster JC, Pear WS, Blacklow SCAnnual review of pathologyThe Varied Roles of Notch in Cancer. Annu Rev Pathol. 2017 Jan 24; 12:245-275.Annu Rev Pathol2016-12-05T00:00:002016The Varied Roles of Notch in Cancer.Authorship 5208061Authorship 5370276Authorship 956246828089446Durzynska I, Xu X, Adelmant G, Ficarro SB, Marto JA, Sliz P, Uljon S, Blacklow SCStructure (London, England : 1993)STK40 Is a Pseudokinase that Binds the E3 Ubiquitin Ligase COP1. Structure. 2017 02 07; 25(2):287-294.Structure2017-01-12T00:00:002017STK40 Is a Pseudokinase that Binds the E3 Ubiquitin Ligase COP1.8784348Blacklow SC, Kim PSNature structural biologyProtein folding and calcium binding defects arising from familial hypercholesterolemia mutations of the LDL receptor. Nat Struct Biol. 1996 Sep; 3(9):758-62.Nat Struct Biol1996-09-01T00:00:001996Protein folding and calcium binding defects arising from familial hypercholesterolemia mutations of the LDL receptor.11896403Beglova N, Blacklow SC, Takagi J, Springer TANature structural biologyCysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation. Nat Struct Biol. 2002 Apr; 9(4):282-7.Nat Struct Biol2002-04-01T00:00:002002Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation.45 Shattuck StHarvard Medical SchoolLhrrb-201b, Bcmp45 Shattuck StBoston02115MA16847353Weng AP, Millholland JM, Yashiro-Ohtani Y, Arcangeli ML, Lau A, Wai C, Del Bianco C, Rodriguez CG, Sai H, Tobias J, Li Y, Wolfe MS, Shachaf C, Felsher D, Blacklow SC, Pear WS, Aster JCGenes & developmentc-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma. Genes Dev. 2006 Aug 01; 20(15):2096-109.Genes Dev2006-07-17T00:00:002006c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma.10194304North CL, Blacklow SCBiochemistryStructural independence of ligand-binding modules five and six of the LDL receptor. Biochemistry. 1999 Mar 30; 38(13):3926-35.Biochemistry1999-03-30T00:00:001999Structural independence of ligand-binding modules five and six of the LDL receptor.10194358Zhang Z, Komives EA, Sugio S, Blacklow SC, Narayana N, Xuong NH, Stock AM, Petsko GA, Ringe DBiochemistryThe role of water in the catalytic efficiency of triosephosphate isomerase. Biochemistry. 1999 Apr 06; 38(14):4389-97.Biochemistry1999-04-06T00:00:001999The role of water in the catalytic efficiency of triosephosphate isomerase.10567577Williams AJ, Blacklow SC, Collins TMolecular and cellular biologyThe zinc finger-associated SCAN box is a conserved oligomerization domain. Mol Cell Biol. 1999 Dec; 19(12):8526-35.Mol Cell Biol1999-12-01T00:00:001999The zinc finger-associated SCAN box is a conserved oligomerization domain.Authorship 972802728334865McMillan BJ, Zimmerman B, Egan ED, Lofgren M, Xu X, Hesser A, Blacklow SCGlycobiologyStructure of human POFUT1, its requirement in ligand-independent oncogenic Notch signaling, and functional effects of Dowling-Degos mutations. Glycobiology. 2017 08 01; 27(8):777-786.Glycobiology2017-08-01T00:00:002017Structure of human POFUT1, its requirement in ligand-independent oncogenic Notch signaling, and functional effects of Dowling-Degos mutations.11669616Koduri V, Blacklow SCBiochemistryFolding determinants of LDL receptor type A modules. Biochemistry. 2001 Oct 30; 40(43):12801-7.Biochemistry2001-10-30T00:00:002001Folding determinants of LDL receptor type A modules.15485896Sanchez-Irizarry C, Carpenter AC, Weng AP, Pear WS, Aster JC, Blacklow SCMolecular and cellular biologyNotch subunit heterodimerization and prevention of ligand-independent proteolytic activation depend, respectively, on a novel domain and the LNR repeats. Mol Cell Biol. 2004 Nov; 24(21):9265-73.Mol Cell Biol2004-11-01T00:00:002004Notch subunit heterodimerization and prevention of ligand-independent proteolytic activation depend, respectively, on a novel domain and the LNR repeats.10704205North CL, Blacklow SCBiochemistrySolution structure of the sixth LDL-A module of the LDL receptor. Biochemistry. 2000 Mar 14; 39(10):2564-71.Biochemistry2000-03-14T00:00:002000Solution structure of the sixth LDL-A module of the LDL receptor.11258891Beglova N, North CL, Blacklow SCBiochemistryBackbone dynamics of a module pair from the ligand-binding domain of the LDL receptor. Biochemistry. 2001 Mar 06; 40(9):2808-15.Biochemistry2001-03-06T00:00:002001Backbone dynamics of a module pair from the ligand-binding domain of the LDL receptor.11572973Takagi J, Beglova N, Yalamanchili P, Blacklow SC, Springer TAProceedings of the National Academy of Sciences of the United States of AmericaDefinition of EGF-like, closely interacting modules that bear activation epitopes in integrin beta subunits. Proc Natl Acad Sci U S A. 2001 Sep 25; 98(20):11175-80.Proc Natl Acad Sci U S A2001-09-25T00:00:002001Definition of EGF-like, closely interacting modules that bear activation epitopes in integrin beta subunits.15100232Boswell EJ, Jeon H, Blacklow SC, Downing AKThe Journal of biological chemistryGlobal defects in the expression and function of the low density lipoprotein receptor (LDLR) associated with two familial hypercholesterolemia mutations resulting in misfolding of the LDLR epidermal growth factor-AB pair. J Biol Chem. 2004 Jul 16; 279(29):30611-21.J Biol Chem2004-04-20T00:00:002004Global defects in the expression and function of the low density lipoprotein receptor (LDLR) associated with two familial hypercholesterolemia mutations resulting in misfolding of the LDLR epidermal growth factor-AB pair.15323557Stolt PC, Vardar D, Blacklow SCBiochemistryThe dual-function disabled-1 PTB domain exhibits site independence in binding phosphoinositide and peptide ligands. Biochemistry. 2004 Aug 31; 43(34):10979-87.Biochemistry2004-08-31T00:00:002004The dual-function disabled-1 PTB domain exhibits site independence in binding phosphoinositide and peptide ligands.15794645Abdul-Aziz D, Fisher C, Beglova N, Blacklow SCBiochemistryFolding and binding integrity of variants of a prototype ligand-binding module from the LDL receptor possessing multiple alanine substitutions. Biochemistry. 2005 Apr 05; 44(13):5075-85.Biochemistry2005-04-05T00:00:002005Folding and binding integrity of variants of a prototype ligand-binding module from the LDL receptor possessing multiple alanine substitutions.16530044Nam Y, Sliz P, Song L, Aster JC, Blacklow SCCellStructural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes. Cell. 2006 Mar 10; 124(5):973-83.Cell2006-03-10T00:00:002006Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes.16678114Lee D, Walsh JD, Mikhailenko I, Yu P, Migliorini M, Wu Y, Krueger S, Curtis JE, Harris B, Lockett S, Blacklow SC, Strickland DK, Wang YXMolecular cellRAP uses a histidine switch to regulate its interaction with LRP in the ER and Golgi. Mol Cell. 2006 May 05; 22(3):423-30.Mol Cell2006-05-05T00:00:002006RAP uses a histidine switch to regulate its interaction with LRP in the ER and Golgi.17658278Fang TC, Yashiro-Ohtani Y, Del Bianco C, Knoblock DM, Blacklow SC, Pear WSImmunityNotch directly regulates Gata3 expression during T helper 2 cell differentiation. Immunity. 2007 Jul; 27(1):100-10.Immunity2007-07-19T00:00:002007Notch directly regulates Gata3 expression during T helper 2 cell differentiation.10669757Rand MD, Grimm LM, Artavanis-Tsakonas S, Patriub V, Blacklow SC, Sklar J, Aster JCMolecular and cellular biologyCalcium depletion dissociates and activates heterodimeric notch receptors. Mol Cell Biol. 2000 Mar; 20(5):1825-35.Mol Cell Biol2000-03-01T00:00:002000Calcium depletion dissociates and activates heterodimeric notch receptors.11741982Stone JR, Maki JL, Blacklow SC, Collins TThe Journal of biological chemistryThe SCAN domain of ZNF174 is a dimer. J Biol Chem. 2002 Feb 15; 277(7):5448-52.J Biol Chem2001-12-11T00:00:002001The SCAN domain of ZNF174 is a dimer.11567528Forster AC, Weissbach H, Blacklow SCAnalytical biochemistryA simplified reconstitution of mRNA-directed peptide synthesis: activity of the epsilon enhancer and an unnatural amino acid. Anal Biochem. 2001 Oct 01; 297(1):60-70.Anal Biochem2001-10-01T00:00:002001A simplified reconstitution of mRNA-directed peptide synthesis: activity of the epsilon enhancer and an unnatural amino acid.10200161Aster JC, Simms WB, Zavala-Ruiz Z, Patriub V, North CL, Blacklow SCBiochemistryThe folding and structural integrity of the first LIN-12 module of human Notch1 are calcium-dependent. Biochemistry. 1999 Apr 13; 38(15):4736-42.Biochemistry1999-04-13T00:00:001999The folding and structural integrity of the first LIN-12 module of human Notch1 are calcium-dependent.21746931Zhao B, Zou J, Wang H, Johannsen E, Peng CW, Quackenbush J, Mar JC, Morton CC, Freedman ML, Blacklow SC, Aster JC, Bernstein BE, Kieff EProceedings of the National Academy of Sciences of the United States of AmericaEpstein-Barr virus exploits intrinsic B-lymphocyte transcription programs to achieve immortal cell growth. 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