MP14Mary-ElizabethPattiMary-Elizabeth Patti, M.D.42.33839600000000-71.1084030000000039922Patti, Mary-Elizabeth617/735-1966Associate Professor of Medicinecatalyst:eCommonsLogineCommons Loginprns:coAuthorOfcoauthor ofFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:address2address line 2vivo:address3address line 3vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionvivo:hasResearchArearesearch areasvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:personInPositionpositionsvivo:phoneNumberphonePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titlerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson11699059Orban T, Landaker E, Ruan Z, Cordeman TP, Weitgasser R, Bonner-Weir S, Jackson RA, Patti MEMetabolism: clinical and experimentalHigh-fructose diet preserves beta-cell mass and prevents diabetes in nonobese diabetic mice: A potential role for increased insulin receptor substrate-2 expression. Metabolism. 2001 Nov; 50(11):1369-76.Metabolism2001-11-01T00:00:002001High-fructose diet preserves beta-cell mass and prevents diabetes in nonobese diabetic mice: A potential role for increased insulin receptor substrate-2 expression.Authorship 1046550229409712Gonzalez-Franquesa A, Patti METrends in endocrinology and metabolism: TEMSqueezing Flux Out of Fat. Trends Endocrinol Metab. 2018 04; 29(4):201-202.Trends Endocrinol Metab2018-02-04T00:00:002018Squeezing Flux Out of Fat.10675357Cusi K, Maezono K, Osman A, Pendergrass M, Patti ME, Pratipanawatr T, DeFronzo RA, Kahn CR, Mandarino LJThe Journal of clinical investigationInsulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle. J Clin Invest. 2000 Feb; 105(3):311-20.J Clin Invest2000-02-01T00:00:002000Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle.Authorship 1052070229371089Arora I, Patti MEMolecular metabolismCan reversal of RYGB also reverse hypoglycemia? Mol Metab. 2018 03; 9:1-3.Mol Metab2018-01-12T00:00:002018Can reversal of RYGB also reverse hypoglycemia?19360006Patti ME, Houten SM, Bianco AC, Bernier R, Larsen PR, Holst JJ, Badman MK, Maratos-Flier E, Mun EC, Pihlajamaki J, Auwerx J, Goldfine ABObesity (Silver Spring, Md.)Serum bile acids are higher in humans with prior gastric bypass: potential contribution to improved glucose and lipid metabolism. Obesity (Silver Spring). 2009 Sep; 17(9):1671-7.Obesity (Silver Spring)2009-04-09T00:00:002009Serum bile acids are higher in humans with prior gastric bypass: potential contribution to improved glucose and lipid metabolism.15895078Tseng YH, Butte AJ, Kokkotou E, Yechoor VK, Taniguchi CM, Kriauciunas KM, Cypess AM, Niinobe M, Yoshikawa K, Patti ME, Kahn CRNature cell biologyPrediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin. Nat Cell Biol. 2005 Jun; 7(6):601-11.Nat Cell Biol2005-05-15T00:00:002005Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin.21331295Halperin F, Patti ME, Skow M, Bajwa M, Goldfine ABJournal of obesityContinuous glucose monitoring for evaluation of glycemic excursions after gastric bypass. J Obes. 2011; 2011:869536.J Obes2011-02-07T00:00:002011Continuous glucose monitoring for evaluation of glycemic excursions after gastric bypass.22638681Simonen M, Dali-Youcef N, Kaminska D, Venesmaa S, Käkelä P, Pääkkönen M, Hallikainen M, Kolehmainen M, Uusitupa M, Moilanen L, Laakso M, Gylling H, Patti ME, Auwerx J, Pihlajamäki JObesity surgeryConjugated bile acids associate with altered rates of glucose and lipid oxidation after Roux-en-Y gastric bypass. Obes Surg. 2012 Sep; 22(9):1473-80.Obes Surg2012-09-01T00:00:002012Conjugated bile acids associate with altered rates of glucose and lipid oxidation after Roux-en-Y gastric bypass.16537411Ilany J, Bilan PJ, Kapur S, Caldwell JS, Patti ME, Marette A, Kahn CRProceedings of the National Academy of Sciences of the United States of AmericaOverexpression of Rad in muscle worsens diet-induced insulin resistance and glucose intolerance and lowers plasma triglyceride level. Proc Natl Acad Sci U S A. 2006 Mar 21; 103(12):4481-6.Proc Natl Acad Sci U S A2006-03-14T00:00:002006Overexpression of Rad in muscle worsens diet-induced insulin resistance and glucose intolerance and lowers plasma triglyceride level.17895322Goldfine AB, Mun EC, Devine E, Bernier R, Baz-Hecht M, Jones DB, Schneider BE, Holst JJ, Patti METhe Journal of clinical endocrinology and metabolismPatients with neuroglycopenia after gastric bypass surgery have exaggerated incretin and insulin secretory responses to a mixed meal. J Clin Endocrinol Metab. 2007 Dec; 92(12):4678-85.J Clin Endocrinol Metab2007-09-25T00:00:002007Patients with neuroglycopenia after gastric bypass surgery have exaggerated incretin and insulin secretory responses to a mixed meal.19549744Pihlajamäki J, Boes T, Kim EY, Dearie F, Kim BW, Schroeder J, Mun E, Nasser I, Park PJ, Bianco AC, Goldfine AB, Patti METhe Journal of clinical endocrinology and metabolismThyroid hormone-related regulation of gene expression in human fatty liver. J Clin Endocrinol Metab. 2009 Sep; 94(9):3521-9.J Clin Endocrinol Metab2009-06-23T00:00:002009Thyroid hormone-related regulation of gene expression in human fatty liver.Authorship 1071519229860335Grizales AM, Patti ME, Lin AP, Beckman JA, Sahni VA, Cloutier E, Fowler KM, Dreyfuss JM, Pan H, Kozuka C, Lee A, Basu R, Pober DM, Gerszten RE, Goldfine ABThe Journal of clinical endocrinology and metabolismMetabolic Effects of Betaine: A Randomized Clinical Trial of Betaine Supplementation in Prediabetes. J Clin Endocrinol Metab. 2018 08 01; 103(8):3038-3049.J Clin Endocrinol Metab2018-08-01T00:00:002018Metabolic Effects of Betaine: A Randomized Clinical Trial of Betaine Supplementation in Prediabetes.15734846Jimenez-Chillaron JC, Hernandez-Valencia M, Reamer C, Fisher S, Joszi A, Hirshman M, Oge A, Walrond S, Przybyla R, Boozer C, Goodyear LJ, Patti MEDiabetesBeta-cell secretory dysfunction in the pathogenesis of low birth weight-associated diabetes: a murine model. Diabetes. 2005 Mar; 54(3):702-11.Diabetes2005-03-01T00:00:002005Beta-cell secretory dysfunction in the pathogenesis of low birth weight-associated diabetes: a murine model.16505226Goldfine AB, Crunkhorn S, Costello M, Gami H, Landaker EJ, Niinobe M, Yoshikawa K, Lo D, Warren A, Jimenez-Chillaron J, Patti MEDiabetesNecdin and E2F4 are modulated by rosiglitazone therapy in diabetic human adipose and muscle tissue. Diabetes. 2006 Mar; 55(3):640-50.Diabetes2006-03-01T00:00:002006Necdin and E2F4 are modulated by rosiglitazone therapy in diabetic human adipose and muscle tissue.15459705Patti ME, Kahn BBNature medicineNutrient sensor links obesity with diabetes risk. Nat Med. 2004 Oct; 10(10):1049-50.Nat Med2004-10-01T00:00:002004Nutrient sensor links obesity with diabetes risk.Authorship 11240120730413Patti ME, Goldfine ABDiabetologiaHypoglycaemia following gastric bypass surgery--diabetes remission in the extreme? Diabetologia. 2010 Nov; 53(11):2276-9.Diabetologia2010-08-21T00:00:002010Hypoglycaemia following gastric bypass surgery--diabetes remission in the extreme?18279023Crunkhorn S, Patti METhyroid : official journal of the American Thyroid AssociationLinks between thyroid hormone action, oxidative metabolism, and diabetes risk? Thyroid. 2008 Feb; 18(2):227-37.Thyroid2008-02-01T00:00:002008Links between thyroid hormone action, oxidative metabolism, and diabetes risk?Authorship 1087868430101281Salehi M, Vella A, McLaughlin T, Patti METhe Journal of clinical endocrinology and metabolismHypoglycemia After Gastric Bypass Surgery: Current Concepts and Controversies. J Clin Endocrinol Metab. 2018 08 01; 103(8):2815-2826.J Clin Endocrinol Metab2018-08-01T00:00:002018Hypoglycemia After Gastric Bypass Surgery: Current Concepts and Controversies.Authorship 11615220168313Halperin F, Patti ME, Goldfine ABObesity (Silver Spring, Md.)Glucagon treatment for post-gastric bypass hypoglycemia. Obesity (Silver Spring). 2010 Sep; 18(9):1858-60.Obesity (Silver Spring)2010-02-18T00:00:002010Glucagon treatment for post-gastric bypass hypoglycemia.Authorship 10916811430190193Adachi Y, De Sousa-Coelho AL, Harata I, Aoun C, Weimer S, Shi X, Gonzalez Herrera KN, Takahashi H, Doherty C, Noguchi Y, Goodyear LJ, Haigis MC, Gerszten RE, Patti MEMolecular metabolisml-Alanine activates hepatic AMP-activated protein kinase and modulates systemic glucose metabolism. Mol Metab. 2018 11; 17:61-70.Mol Metab2018-08-11T00:00:002018l-Alanine activates hepatic AMP-activated protein kinase and modulates systemic glucose metabolism.Authorship 1092605430237160Rosen ED, Kaestner KH, Natarajan R, Patti ME, Sallari R, Sander M, Susztak KDiabetesEpigenetics and Epigenomics: Implications for Diabetes and Obesity. Diabetes. 2018 10; 67(10):1923-1931.Diabetes2018-10-01T00:00:002018Epigenetics and Epigenomics: Implications for Diabetes and Obesity.15131119Blüher M, Patti ME, Gesta S, Kahn BB, Kahn CRThe Journal of biological chemistryIntrinsic heterogeneity in adipose tissue of fat-specific insulin receptor knock-out mice is associated with differences in patterns of gene expression. J Biol Chem. 2004 Jul 23; 279(30):31891-901.J Biol Chem2004-05-06T00:00:002004Intrinsic heterogeneity in adipose tissue of fat-specific insulin receptor knock-out mice is associated with differences in patterns of gene expression.16434556Kuhl JE, Ruderman NB, Musi N, Goodyear LJ, Patti ME, Crunkhorn S, Dronamraju D, Thorell A, Nygren J, Ljungkvist O, Degerblad M, Stahle A, Brismar TB, Andersen KL, Saha AK, Efendic S, Bavenholm PNAmerican journal of physiology. Endocrinology and metabolismExercise training decreases the concentration of malonyl-CoA and increases the expression and activity of malonyl-CoA decarboxylase in human muscle. Am J Physiol Endocrinol Metab. 2006 Jun; 290(6):E1296-303.Am J Physiol Endocrinol Metab2006-01-24T00:00:002006Exercise training decreases the concentration of malonyl-CoA and increases the expression and activity of malonyl-CoA decarboxylase in human muscle.17416903Crunkhorn S, Dearie F, Mantzoros C, Gami H, da Silva WS, Espinoza D, Faucette R, Barry K, Bianco AC, Patti METhe Journal of biological chemistryPeroxisome proliferator activator receptor gamma coactivator-1 expression is reduced in obesity: potential pathogenic role of saturated fatty acids and p38 mitogen-activated protein kinase activation. J Biol Chem. 2007 May 25; 282(21):15439-50.J Biol Chem2007-04-06T00:00:002007Peroxisome proliferator activator receptor gamma coactivator-1 expression is reduced in obesity: potential pathogenic role of saturated fatty acids and p38 mitogen-activated protein kinase activation.Authorship 11088911030344184Stanford KI, Rasmussen M, Baer LA, Lehnig AC, Rowland LA, White JD, So K, De Sousa-Coelho AL, Hirshman MF, Patti ME, Rando OJ, Goodyear LJDiabetesPaternal Exercise Improves Glucose Metabolism in Adult Offspring. Diabetes. 2018 12; 67(12):2530-2540.Diabetes2018-10-21T00:00:002018Paternal Exercise Improves Glucose Metabolism in Adult Offspring.22511876Radford EJ, Isganaitis E, Jimenez-Chillaron J, Schroeder J, Molla M, Andrews S, Didier N, Charalambous M, McEwen K, Marazzi G, Sassoon D, Patti ME, Ferguson-Smith ACPLoS geneticsAn unbiased assessment of the role of imprinted genes in an intergenerational model of developmental programming. PLoS Genet. 2012; 8(4):e1002605.PLoS Genet2012-04-12T00:00:002012An unbiased assessment of the role of imprinted genes in an intergenerational model of developmental programming.Authorship 111519819017762Jimenez-Chillaron JC, Isganaitis E, Charalambous M, Gesta S, Pentinat-Pelegrin T, Faucette RR, Otis JP, Chow A, Diaz R, Ferguson-Smith A, Patti MEDiabetesIntergenerational transmission of glucose intolerance and obesity by in utero undernutrition in mice. Diabetes. 2009 Feb; 58(2):460-8.Diabetes2008-11-18T00:00:002008Intergenerational transmission of glucose intolerance and obesity by in utero undernutrition in mice.21149503Goldfine AB, Gerwien RW, Kolberg JA, O'Shea S, Hamren S, Hein GP, Xu XM, Patti MEClinical chemistryBiomarkers in fasting serum to estimate glucose tolerance, insulin sensitivity, and insulin secretion. Clin Chem. 2011 Feb; 57(2):326-37.Clin Chem2010-12-13T00:00:002010Biomarkers in fasting serum to estimate glucose tolerance, insulin sensitivity, and insulin secretion.18590686Woo M, Patti MECell metabolismDiabetes risk begins in utero. Cell Metab. 2008 Jul; 8(1):5-7.Cell Metab2008-07-01T00:00:002008Diabetes risk begins in utero.Authorship 113929412Authorship 1136895530773442Franquet E, Watts G, Kolodny GM, Goldfine AB, Patti MESurgery for obesity and related diseases : official journal of the American Society for Bariatric SurgeryPET-CT reveals increased intestinal glucose uptake after gastric surgery. Surg Obes Relat Dis. 2019 Apr; 15(4):643-649.Surg Obes Relat Dis2019-01-25T00:00:002019PET-CT reveals increased intestinal glucose uptake after gastric surgery.30843877Osataphan S, Macchi C, Singhal G, Chimene-Weiss J, Sales V, Kozuka C, Dreyfuss JM, Pan H, Tangcharoenpaisan Y, Morningstar J, Gerszten R, Patti MEJCI insightSGLT2 inhibition reprograms systemic metabolism via FGF21-dependent and -independent mechanisms. JCI Insight. 2019 03 07; 4(5).JCI Insight2019-03-07T00:00:002019SGLT2 inhibition reprograms systemic metabolism via FGF21-dependent and -independent mechanisms.D009767Disorders47412050.447665Obesity, MorbidAuthorship 11449361330976983Mulla CM, Goldfine AB, Dreyfuss JM, Houten S, Pan H, Pober DM, Wewer Albrechtsen NJ, Svane MS, Schmidt JB, Holst JJ, Craig CM, McLaughlin TL, Patti MEObesity surgeryPlasma FGF-19 Levels are Increased in Patients with Post-Bariatric Hypoglycemia. Obes Surg. 2019 07; 29(7):2092-2099.Obes Surg2019-07-01T00:00:002019Plasma FGF-19 Levels are Increased in Patients with Post-Bariatric Hypoglycemia.D015390Procedures2788210.517549Gastric BypassAuthorship 1269237D007333Disorders99838580.365005Insulin ResistanceD007003Disorders3988570.5731HypoglycemiaD050110Procedures3109400.485121Bariatric SurgeryAuthorship 1151215231063991Osataphan S, Patti METhe Journal of clinical investigationTrim the gut, lose the weight - and the bone. J Clin Invest. 2019 05 06; 129(6):2184-2186.J Clin Invest2019-05-06T00:00:002019Trim the gut, lose the weight - and the bone.MedicinePediatricsSurgeryGastroenterologyJoslinEndocrinologyBeth Israel Deaconess Medical CenterBrigham and Women's HospitalJoslin Diabetes CenterAuthorship 1156368231127415Su L, Patti MECurrent diabetes reportsPaternal Nongenetic Intergenerational Transmission of Metabolic Disease Risk. Curr Diab Rep. 2019 05 24; 19(7):38.Curr Diab Rep2019-05-24T00:00:002019Paternal Nongenetic Intergenerational Transmission of Metabolic Disease Risk.Authorship 1386362CSM3ChristosMantzorosChristos Mantzoros, M.D.42.34022770000000-71.1058540000000061846Mantzoros, ChristosProfessor of MedicineCT44ChristopherThompsonChristopher Thompson, M.D.42.33510370000000-71.1061649000000018681Thompson, ChristopherProfessor of MedicineEI4ElviraIsganaitisElvira Isganaitis, M.D.42.36241700000000-71.068937000000006821Isganaitis, ElviraAssistant Professor of PediatricsCRK3C.KahnC. Ronald Kahn, M.D.42.33839600000000-71.1084030000000084269Kahn, C.Mary K. Iacocca Professor of MedicineWMS5WilliamSullivanWilliam McHugh Sullivan, M.D.42.33839600000000-71.1084030000000026771Sullivan, WilliamAssistant Professor of MedicineSJL22SarahLessardSarah Lessard, Ph.D.42.33839600000000-71.1084030000000066720Lessard, SarahAssistant Professor of MedicineAuthorship 1161029231227985Rogowitz E, Patti ME, Lawler HMObesity surgeryTime to Dump Late Dumping Syndrome Terminology. Obes Surg. 2019 09; 29(9):2985-2986.Obes Surg2019-09-01T00:00:002019Time to Dump Late Dumping Syndrome Terminology.11177selected publications10.00630.00238196583research areas3.574460.013164390coauthor of197.17335.346160similar toSAS81ScottShikoraScott Alan Shikora, M.D.103372Shikora, ScottProfessor of SurgeryCA43CristinaAguayo-MazzucatoCristina Aguayo-Mazzucato, M.D., Ph.D.42.33839600000000-71.1084030000000066986Aguayo-Mazzucato, CristinaAssistant Professor of MedicineGLK1GeorgeKingGeorge Liang King, M.D.42.33839600000000-71.1084030000000068100King, GeorgeThomas J. Beatson, Jr. Professor of Medicine in the Field of DiabetesOPG2OmGandaOm Prakash Ganda, M.B.,B.S., M.D.42.33839600000000-71.1084030000000081423Ganda, OmAssociate Professor of Medicine, Part-timeVE17VissarionEfthymiouVissarion Efthymiou, Ph.D.184024Efthymiou, VissarionResearch Fellow in MedicineAuthorship 12042431331714583Mulla CM, Zavitsanou S, Laguna Sanz AJ, Pober D, Richardson L, Walcott P, Arora I, Newswanger B, Cummins MJ, Prestrelski SJ, Doyle FJ, Dassau E, Patti METhe Journal of clinical endocrinology and metabolismA Randomized, Placebo-Controlled Double-Blind Trial of a Closed-Loop Glucagon System for Postbariatric Hypoglycemia. J Clin Endocrinol Metab. 2020 04 01; 105(4).J Clin Endocrinol Metab2020-04-01T00:00:002020A Randomized, Placebo-Controlled Double-Blind Trial of a Closed-Loop Glucagon System for Postbariatric Hypoglycemia.true1Assistant Professor of MedicineAssistant Professor of Medicinetrue1Associate Professor of Medicine, Part-timeAssociate Professor of Medicine, Part-timetrue1Professor of SurgeryProfessor of Surgerytrue1Assistant Professor of PediatricsAssistant Professor of Pediatricstrue1Assistant Professor of MedicineAssistant Professor of Medicinetrue1Mary K. Iacocca Professor of MedicineMary K. Iacocca Professor of Medicinetrue1Professor of MedicineProfessor of Medicinetrue1Instructor in MedicineInstructor in MedicineAuthorship 1213608931880793Noor N, Cardenas A, Rifas-Shiman SL, Pan H, Dreyfuss JM, Oken E, Hivert MF, James-Todd T, Patti ME, Isganaitis EJAMA network openAssociation of Periconception Paternal Body Mass Index With Persistent Changes in DNA Methylation of Offspring in Childhood. JAMA Netw Open. 2019 12 02; 2(12):e1916777.JAMA Netw Open2019-12-02T00:00:002019Association of Periconception Paternal Body Mass Index With Persistent Changes in DNA Methylation of Offspring in Childhood.Authorship 1218475531931977Simonson DC, Vernon A, Foster K, Halperin F, Patti ME, Goldfine ABSurgery for obesity and related diseases : official journal of the American Society for Bariatric SurgeryAdjustable gastric band surgery or medical management in patients with type 2 diabetes and obesity: three-year results of a randomized trial. Surg Obes Relat Dis. 2019 Dec; 15(12):2052-2059.Surg Obes Relat Dis2019-04-16T00:00:002019Adjustable gastric band surgery or medical management in patients with type 2 diabetes and obesity: three-year results of a randomized trial.true1Assistant Professor of MedicineAssistant Professor of MedicineAuthorship 1748347true1Professor of MedicineProfessor of MedicineAuthorship 1519273Authorship 1268698232694727Harper ME, Patti MENature metabolismMetabolic terminology: what's in a name? Nat Metab. 2020 06; 2(6):476-477.Nat Metab2020-06-01T00:00:002020Metabolic terminology: what's in a name?Authorship 12797361332853041Parmer C, De Sousa-Coelho AL, Cheng HS, Daher G, Burkart A, Dreyfuss JM, Pan H, Prenner JC, Keilson JM, Pande R, Henkin S, Feinberg MW, Patti ME, Creager MAVascular medicine (London, England)Skeletal muscle expression of adipose-specific phospholipase in peripheral artery disease. Vasc Med. 2020 10; 25(5):401-410.Vasc Med2020-08-27T00:00:002020Skeletal muscle expression of adipose-specific phospholipase in peripheral artery disease.Authorship 2046271Authorship 1306601233239898Sheehan A, Patti MEDiabetes, metabolic syndrome and obesity : targets and therapyHypoglycemia After Upper Gastrointestinal Surgery: Clinical Approach to Assessment, Diagnosis, and Treatment. Diabetes Metab Syndr Obes. 2020; 13:4469-4482.Diabetes Metab Syndr Obes2020-11-19T00:00:002020Hypoglycemia After Upper Gastrointestinal Surgery: Clinical Approach to Assessment, Diagnosis, and Treatment.Authorship 155841533770509Kusuyama J, Alves-Wagner AB, Conlin RH, Makarewicz NS, Albertson BG, Prince NB, Kobayashi S, Kozuka C, Møller M, Bjerre M, Fuglsang J, Miele E, Middelbeek RJW, Xiudong Y, Xia Y, Garneau L, Bhattacharjee J, Aguer C, Patti ME, Hirshman MF, Jessen N, Hatta T, Ovesen PG, Adamo KB, Nozik-Grayck E, Goodyear LJCell metabolismPlacental superoxide dismutase 3 mediates benefits of maternal exercise on offspring health. Cell Metab. 2021 05 04; 33(5):939-956.e8.Cell Metab2021-03-25T00:00:002021Placental superoxide dismutase 3 mediates benefits of maternal exercise on offspring health.Authorship 134262319Authorship 1355043633974064Lee D, Dreyfuss JM, Sheehan A, Puleio A, Mulla CM, Patti METhe Journal of clinical endocrinology and metabolismGlycemic Patterns Are Distinct in Post-Bariatric Hypoglycemia After Gastric Bypass (PBH-RYGB). J Clin Endocrinol Metab. 2021 07 13; 106(8):2291-2303.J Clin Endocrinol Metab2021-07-13T00:00:002021Glycemic Patterns Are Distinct in Post-Bariatric Hypoglycemia After Gastric Bypass (PBH-RYGB).Authorship 1359253934027090Wolkowicz KL, Aiello EM, Vargas E, Teymourian H, Tehrani F, Wang J, Pinsker JE, Doyle FJ, Patti ME, Laffel LM, Dassau EBioengineering & translational medicineA review of biomarkers in the context of type 1 diabetes: Biological sensing for enhanced glucose control. Bioeng Transl Med. 2021 May; 6(2):e10201.Bioeng Transl Med2020-12-09T00:00:002020A review of biomarkers in the context of type 1 diabetes: Biological sensing for enhanced glucose control.Authorship 1362595234103205Sheehan A, Patti METhe Journal of emergency medicineLetter to the Editor. J Emerg Med. 2021 09; 61(3):348-350.J Emerg Med2021-06-05T00:00:002021Letter to the Editor.Authorship 13774411034294589Fischer LE, Wolfe BM, Fino N, Elman MR, Flum DR, Mitchell JE, Pomp A, Pories WJ, Purnell JQ, Patti MESurgery for obesity and related diseases : official journal of the American Society for Bariatric SurgeryPostbariatric hypoglycemia: symptom patterns and associated risk factors in the Longitudinal Assessment of Bariatric Surgery study. Surg Obes Relat Dis. 2021 10; 17(10):1787-1798.Surg Obes Relat Dis2021-05-19T00:00:002021Postbariatric hypoglycemia: symptom patterns and associated risk factors in the Longitudinal Assessment of Bariatric Surgery study.Authorship 1395614334543416Ferraz-Bannitz R, Kashyap S, Patti METhe Journal of clinical endocrinology and metabolismBariatric Surgery: It's Not Just Incretins! J Clin Endocrinol Metab. 2022 01 18; 107(2):e883-e885.J Clin Endocrinol Metab2022-01-18T00:00:002022Bariatric Surgery: It's Not Just Incretins!Authorship 22398511Authorship 14103192134845204Dreyfuss JM, Yuchi Y, Dong X, Efthymiou V, Pan H, Simonson DC, Vernon A, Halperin F, Aryal P, Konkar A, Sebastian Y, Higgs BW, Grimsby J, Rondinone CM, Kasif S, Kahn BB, Foster K, Seeley R, Goldfine A, Djordjilovic V, Patti MENature communicationsHigh-throughput mediation analysis of human proteome and metabolome identifies mediators of post-bariatric surgical diabetes control. Nat Commun. 2021 11 29; 12(1):6951.Nat Commun2021-11-29T00:00:002021High-throughput mediation analysis of human proteome and metabolome identifies mediators of post-bariatric surgical diabetes control.35043720Vargas E, Aiello EM, Pinsker JE, Teymourian H, Tehrani F, Church MM, Laffel LM, Doyle FJ, Patti ME, Dassau E, Wang JJournal of diabetes science and technologyDevelopment of a Novel Insulin Sensor for Clinical Decision-Making. J Diabetes Sci Technol. 2023 Jul; 17(4):1029-1037.J Diabetes Sci Technol2022-01-19T00:00:002022Development of a Novel Insulin Sensor for Clinical Decision-Making.35042723Gupta A, Shamsi F, Altemose N, Dorlhiac GF, Cypess AM, White AP, Yosef N, Patti ME, Tseng YH, Streets AGenome researchCharacterization of transcript enrichment and detection bias in single-nucleus RNA-seq for mapping of distinct human adipocyte lineages. Genome Res. 2022 02; 32(2):242-257.Genome Res2022-01-18T00:00:002022Characterization of transcript enrichment and detection bias in single-nucleus RNA-seq for mapping of distinct human adipocyte lineages.true1Associate Professor of MedicineAssociate Professor of MedicineAuthorship 14257499Authorship 14270478Authorship 14317078Authorship 143003923Authorship 14316823Authorship 1430131935118893Aiello EM, Pinsker JE, Vargas E, Teymourian H, Tehrani F, Church MM, Laffel LM, Doyle FJ, Patti ME, Wang J, Dassau EJournal of diabetes science and technologyClinical Evaluation of a Novel Insulin Immunosensor. J Diabetes Sci Technol. 2023 Jul; 17(4):1038-1048.J Diabetes Sci Technol2022-02-04T00:00:002022Clinical Evaluation of a Novel Insulin Immunosensor.35133603Addison P, Carsky K, Patti ME, Roslin MObesity surgeryHypoglycemia and Dysautonomia After Bariatric Surgery: a Systematic Review and Perspective. Obes Surg. 2022 05; 32(5):1681-1688.Obes Surg2022-02-08T00:00:002022Hypoglycemia and Dysautonomia After Bariatric Surgery: a Systematic Review and Perspective.35100352Kozuka C, Efthymiou V, Sales VM, Zhou L, Osataphan S, Yuchi Y, Chimene-Weiss J, Mulla C, Isganaitis E, Desmond J, Sanechika S, Kusuyama J, Goodyear L, Shi X, Gerszten RE, Aguayo-Mazzucato C, Carapeto P, Teixeira SD, Sandoval D, Alonso-Curbelo D, Wu L, Qi J, Patti MEDiabetesBromodomain Inhibition Reveals FGF15/19 As a Target of Epigenetic Regulation and Metabolic Control. Diabetes. 2022 05 01; 71(5):1023-1033.Diabetes2022-05-01T00:00:002022Bromodomain Inhibition Reveals FGF15/19 As a Target of Epigenetic Regulation and Metabolic Control.35137513Sheehan A, Goldfine A, Bajwa M, Wolfs D, Kozuka C, Piper J, Fowler K, Patti MEDiabetes, obesity & metabolismPramlintide for post-bariatric hypoglycaemia. Diabetes Obes Metab. 2022 06; 24(6):1021-1028.Diabetes Obes Metab2022-03-09T00:00:002022Pramlintide for post-bariatric hypoglycaemia.Authorship 2513753Authorship 143765411Authorship 14363562Authorship 1442889835320365Kirwan JP, Courcoulas AP, Cummings DE, Goldfine AB, Kashyap SR, Simonson DC, Arterburn DE, Gourash WF, Vernon AH, Jakicic JM, Patti ME, Wolski K, Schauer PRDiabetes careDiabetes Remission in the Alliance of Randomized Trials of Medicine Versus Metabolic Surgery in Type 2 Diabetes (ARMMS-T2D). Diabetes Care. 2022 07 07; 45(7):1574-1583.Diabetes Care2022-07-07T00:00:002022Diabetes Remission in the Alliance of Randomized Trials of Medicine Versus Metabolic Surgery in Type 2 Diabetes (ARMMS-T2D).35267142Efthymiou V, Patti MECurrent diabetes reportsIt Is Not Just Fat: Dissecting the Heterogeneity of Adipose Tissue Function. Curr Diab Rep. 2022 04; 22(4):177-187.Curr Diab Rep2022-03-10T00:00:002022It Is Not Just Fat: Dissecting the Heterogeneity of Adipose Tissue Function.35233923Simonson DC, Hu B, Arterburn DE, Schauer PR, Kashyap SR, Courcoulas AP, Cummings DE, Patti ME, Gourash WF, Vernon AH, Jakicic JM, Kirwan JPDiabetes, obesity & metabolismAlliance of Randomized Trials of Medicine vs Metabolic Surgery in Type 2 Diabetes (ARMMS-T2D): Study rationale, design, and methods. Diabetes Obes Metab. 2022 07; 24(7):1206-1215.Diabetes Obes Metab2022-03-16T00:00:002022Alliance of Randomized Trials of Medicine vs Metabolic Surgery in Type 2 Diabetes (ARMMS-T2D): Study rationale, design, and methods.Authorship 14591289Authorship 14606781435715001Vargas E, Aiello EM, Ben Hassine A, Ruiz-Valdepeñas Montiel V, Pinsker JE, Church MM, Laffel LM, Doyle FJ, Patti ME, Dassau E, Wang JAnalytical chemistryConcept of the "Universal Slope": Toward Substantially Shorter Decentralized Insulin Immunoassays. Anal Chem. 2022 07 05; 94(26):9217-9225.Anal Chem2022-06-17T00:00:002022Concept of the "Universal Slope": Toward Substantially Shorter Decentralized Insulin Immunoassays.35653647Wu Y, Tehrani F, Teymourian H, Mack J, Shaver A, Reynoso M, Kavner J, Huang N, Furmidge A, Duvvuri A, Nie Y, Laffel LM, Doyle FJ, Patti ME, Dassau E, Wang J, Arroyo-Currás NAnalytical chemistryMicroneedle Aptamer-Based Sensors for Continuous, Real-Time Therapeutic Drug Monitoring. Anal Chem. 2022 06 14; 94(23):8335-8345.Anal Chem2022-06-02T00:00:002022Microneedle Aptamer-Based Sensors for Continuous, Real-Time Therapeutic Drug Monitoring.Authorship 14880204Authorship 14895892Authorship 1495263336074258Patience N, Sheehan A, Cummings C, Patti MECurrent obesity reportsMedical Nutrition Therapy and Other Approaches to Management of Post-bariatric Hypoglycemia: A Team-Based Approach. Curr Obes Rep. 2022 Dec; 11(4):277-286.Curr Obes Rep2022-09-08T00:00:002022Medical Nutrition Therapy and Other Approaches to Management of Post-bariatric Hypoglycemia: A Team-Based Approach.36001217Dong X, Su L, Patti MECurrent diabetes reportsGrowth Hormone and Counterregulation in the Pathogenesis of Diabetes. Curr Diab Rep. 2022 10; 22(10):511-524.Curr Diab Rep2022-08-24T00:00:002022Growth Hormone and Counterregulation in the Pathogenesis of Diabetes.36289368Sandoval DA, Patti MENature reviews. EndocrinologyGlucose metabolism after bariatric surgery: implications for T2DM remission and hypoglycaemia. Nat Rev Endocrinol. 2023 03; 19(3):164-176.Nat Rev Endocrinol2022-10-26T00:00:002022Glucose metabolism after bariatric surgery: implications for T2DM remission and hypoglycaemia.Authorship 16998812Authorship 1533662836933618Parra-Vargas M, Bouret SG, Bruning JC, de Moura EG, Garland T, Lisboa PC, Ozanne SE, Patti ME, Plagemann A, Speakman JR, Tena-Sempere M, Vergely C, Zeltser LM, Jiménez-Chillarón JCMolecular metabolismThe long-lasting shadow of litter size in rodents: litter size is an underreported variable that strongly determines adult physiology. Mol Metab. 2023 05; 71:101707.Mol Metab2023-03-16T00:00:002023The long-lasting shadow of litter size in rodents: litter size is an underreported variable that strongly determines adult physiology.37046360Cummings C, Jiang A, Sheehan A, Ferraz-Bannitz R, Puleio A, Simonson DC, Dreyfuss JM, Patti MEDiabetes, obesity & metabolismContinuous glucose monitoring in patients with post-bariatric hypoglycaemia reduces hypoglycaemia and glycaemic variability. Diabetes Obes Metab. 2023 08; 25(8):2191-2202.Diabetes Obes Metab2023-05-03T00:00:002023Continuous glucose monitoring in patients with post-bariatric hypoglycaemia reduces hypoglycaemia and glycaemic variability.Authorship 15541345Authorship 1564756837286033Gupta A, Efthymiou V, Kodani SD, Shamsi F, Patti ME, Tseng YH, Streets AMolecular metabolismMapping the transcriptional landscape of human white and brown adipogenesis using single-nuclei RNA-seq. Mol Metab. 2023 08; 74:101746.Mol Metab2023-06-05T00:00:002023Mapping the transcriptional landscape of human white and brown adipogenesis using single-nuclei RNA-seq.37611129Osataphan S, Vamvini M, Rosen ED, Pei L, Erlikh N, Singh G, Dhorajiya P, Parker JA, Dreyfuss JM, Rattani A, Patti METhe New England journal of medicineAnti-Insulin Receptor Antibody for Malignant Insulinoma and Refractory Hypoglycemia. N Engl J Med. 2023 Aug 24; 389(8):767-769.N Engl J Med2023-08-24T00:00:002023Anti-Insulin Receptor Antibody for Malignant Insulinoma and Refractory Hypoglycemia.Authorship 15915874Authorship 15907615Authorship 15817061Authorship 158941814Authorship 15853041137733932Wu Y, Tehrani F, Teymourian H, Mack J, Shaver A, Reynoso M, Kavner J, Huang N, Furmidge A, Duvvuri A, Nie Y, Laffel LM, Doyle FJ, Patti ME, Dassau E, Wang J, Arroyo-Currás NAnalytical chemistryCorrection to "Microneedle Aptamer-Based Sensors for Continuous, Real-Time Therapeutic Drug Monitoring". Anal Chem. 2023 Oct 03; 95(39):14830-14831.Anal Chem2023-09-21T00:00:002023Correction to "Microneedle Aptamer-Based Sensors for Continuous, Real-Time Therapeutic Drug Monitoring".37667837Puleio A, Sheehan A, Musen G, Patti MEObesity (Silver Spring, Md.)Cognition in patients with post-bariatric hypoglycemia. Obesity (Silver Spring). 2024 Mar; 32(3):466-471.Obesity (Silver Spring)2023-09-05T00:00:002023Cognition in patients with post-bariatric hypoglycemia.37652072Bally L, Khoo B, Knop F, Madsbad S, Patti ME, Tan TThe lancet. Diabetes & endocrinologyCall for prospective studies of continuous glucose monitoring to define the glycaemic response to bariatric surgery. Lancet Diabetes Endocrinol. 2023 10; 11(10):712-714.Lancet Diabetes Endocrinol2023-08-28T00:00:002023Call for prospective studies of continuous glucose monitoring to define the glycaemic response to bariatric surgery.37590453Patti METhe New England journal of medicineTriple G Agonists - A Home Run for Obesity? N Engl J Med. 2023 Aug 10; 389(6):562-563.N Engl J Med2023-08-10T00:00:002023Triple G Agonists - A Home Run for Obesity?true1Thomas J. Beatson, Jr. Professor of Medicine in the Field of DiabetesThomas J. Beatson, Jr. Professor of Medicine in the Field of Diabetestrue1Clinical Fellow in MedicineClinical Fellow in Medicinetrue1Research Fellow in MedicineResearch Fellow in MedicineAuthorship 1601238337888936Osataphan S, Rattani A, Patti METhe New England journal of medicineMore on Anti-Insulin Receptor Antibody in Malignant Insulinoma and Refractory Hypoglycemia. Reply. N Engl J Med. 2023 Oct 26; 389(17):1635.N Engl J Med2023-10-26T00:00:002023More on Anti-Insulin Receptor Antibody in Malignant Insulinoma and Refractory Hypoglycemia. Reply.Authorship 1605715337946403Aiello EM, Laffel LM, Patti ME, Doyle FJJournal of diabetes science and technologyKetone-Based Alert System for Insulin Pump Failures. J Diabetes Sci Technol. 2023 Nov 09; 19322968231209339.J Diabetes Sci Technol2023-11-09T00:00:002023Ketone-Based Alert System for Insulin Pump Failures.true1Member of the Faculty of SurgeryMember of the Faculty of SurgeryAbdelrahmanNimeriAbdelrahman Nimeri, M.B.,B.Ch.218063Nimeri, AbdelrahmanMember of the Faculty of SurgeryAuthorship 1621560338231642Gaglia JL, Laffel LM, Patti METhe New England journal of medicineMore on Semaglutide in Early Type 1 Diabetes. N Engl J Med. 2024 Jan 18; 390(3):291.N Engl J Med2024-01-18T00:00:002024More on Semaglutide in Early Type 1 Diabetes.Authorship 5604108Authorship 16296632Authorship 1630150738421647Lu C, Wolfs D, El Ghormli L, Levitsky LL, Levitt Katz LE, Laffel LM, Patti ME, Isganaitis EJAMA network openGrowth Hormone Mediators and Glycemic Control in Youths With Type 2 Diabetes: A Secondary Analysis of a Randomized Clinical Trial. JAMA Netw Open. 2024 Feb 05; 7(2):e240447.JAMA Netw Open2024-02-05T00:00:002024Growth Hormone Mediators and Glycemic Control in Youths With Type 2 Diabetes: A Secondary Analysis of a Randomized Clinical Trial.38411644Courcoulas AP, Patti ME, Hu B, Arterburn DE, Simonson DC, Gourash WF, Jakicic JM, Vernon AH, Beck GJ, Schauer PR, Kashyap SR, Aminian A, Cummings DE, Kirwan JPJAMALong-Term Outcomes of Medical Management vs Bariatric Surgery in Type 2 Diabetes. JAMA. 2024 02 27; 331(8):654-664.JAMA2024-02-27T00:00:002024Long-Term Outcomes of Medical Management vs Bariatric Surgery in Type 2 Diabetes.Authorship 5789312Authorship 1573694Authorship 4124944Authorship 2527967Authorship 650840123884649Patti MEProceedings of the National Academy of Sciences of the United States of AmericaReducing maternal weight improves offspring metabolism and alters (or modulates) methylation. Proc Natl Acad Sci U S A. 2013 Aug 06; 110(32):12859-60.Proc Natl Acad Sci U S A2013-07-24T00:00:002013Reducing maternal weight improves offspring metabolism and alters (or modulates) methylation.Authorship 2233402Authorship 678385824069155Colaneri A, Wang T, Pagadala V, Kittur J, Staffa NG, Peddada SD, Isganaitis E, Patti ME, Birnbaumer LPloS oneA minimal set of tissue-specific hypomethylated CpGs constitute epigenetic signatures of developmental programming. PLoS One. 2013; 8(9):e72670.PLoS One2013-09-12T00:00:002013A minimal set of tissue-specific hypomethylated CpGs constitute epigenetic signatures of developmental programming.Authorship 2506182Authorship 698320224165996Goldfine AB, Patti MENature reviews. EndocrinologyDiabetes: Bariatric surgery for T2DM--cure, or remission and relapse? Nat Rev Endocrinol. 2014 Jan; 10(1):8-9.Nat Rev Endocrinol2013-10-29T00:00:002013Diabetes: Bariatric surgery for T2DM--cure, or remission and relapse?Authorship 3086452Authorship 4223112424668543Middelbeek RJ, James-Todd T, Patti ME, Brown FMObesity surgeryShort-term insulin requirements following gastric bypass surgery in severely obese women with type 1 diabetes. Obes Surg. 2014 Sep; 24(9):1442-6.Obes Surg2014-09-01T00:00:002014Short-term insulin requirements following gastric bypass surgery in severely obese women with type 1 diabetes.Authorship 3130871Authorship 4720777Authorship 71946515Authorship 7173401Authorship 723824224186867Isganaitis E, Woo M, Ma H, Chen M, Kong W, Lytras A, Sales V, Decoste-Lopez J, Lee KJ, Leatherwood C, Lee D, Fitzpatrick C, Gall W, Watkins S, Patti MEDiabetesDevelopmental programming by maternal insulin resistance: hyperinsulinemia, glucose intolerance, and dysregulated lipid metabolism in male offspring of insulin-resistant mice. Diabetes. 2014 Feb; 63(2):688-700.Diabetes2013-11-01T00:00:002013Developmental programming by maternal insulin resistance: hyperinsulinemia, glucose intolerance, and dysregulated lipid metabolism in male offspring of insulin-resistant mice.24468184Patti ME, Goldfine ABGastroenterologyHypoglycemia after gastric bypass: the dark side of GLP-1. Gastroenterology. 2014 Mar; 146(3):605-8.Gastroenterology2014-01-24T00:00:002014Hypoglycemia after gastric bypass: the dark side of GLP-1.24432996Wewalka M, Patti ME, Barbato C, Houten SM, Goldfine ABThe Journal of clinical endocrinology and metabolismFasting serum taurine-conjugated bile acids are elevated in type 2 diabetes and do not change with intensification of insulin. J Clin Endocrinol Metab. 2014 Apr; 99(4):1442-51.J Clin Endocrinol Metab2014-01-16T00:00:002014Fasting serum taurine-conjugated bile acids are elevated in type 2 diabetes and do not change with intensification of insulin.Authorship 2692688Authorship 2974391Authorship 727006224757197Goldfine AB, Patti MEDiabetesDiabetes improvement following Roux-en-Y gastric bypass: understanding dynamic changes in insulin secretion and action. Diabetes. 2014 May; 63(5):1454-6.Diabetes2014-05-01T00:00:002014Diabetes improvement following Roux-en-Y gastric bypass: understanding dynamic changes in insulin secretion and action.Authorship 3730072Authorship 3115432Authorship 2795322Authorship 33101Authorship 7459173Authorship 7491221225011554Radford EJ, Ito M, Shi H, Corish JA, Yamazawa K, Isganaitis E, Seisenberger S, Hore TA, Reik W, Erkek S, Peters AHFM, Patti ME, Ferguson-Smith ACScience (New York, N.Y.)In utero effects. In utero undernourishment perturbs the adult sperm methylome and intergenerational metabolism. Science. 2014 Aug 15; 345(6198):1255903.Science2014-07-10T00:00:002014In utero effects. In utero undernourishment perturbs the adult sperm methylome and intergenerational metabolism.Authorship 765168225194176Ma H, Patti MEBest practice & research. Clinical gastroenterologyBile acids, obesity, and the metabolic syndrome. Best Pract Res Clin Gastroenterol. 2014 Aug; 28(4):573-83.Best Pract Res Clin Gastroenterol2014-07-11T00:00:002014Bile acids, obesity, and the metabolic syndrome.Authorship 7708878Authorship 770847725059784Iovino S, Burkart AM, Kriauciunas K, Warren L, Hughes KJ, Molla M, Lee YK, Patti ME, Kahn CRDiabetesGenetic insulin resistance is a potent regulator of gene expression and proliferation in human iPS cells. Diabetes. 2014 Dec; 63(12):4130-42.Diabetes2014-07-24T00:00:002014Genetic insulin resistance is a potent regulator of gene expression and proliferation in human iPS cells.25251340Perng W, Gillman MW, Fleisch AF, Michalek RD, Watkins SM, Isganaitis E, Patti ME, Oken EObesity (Silver Spring, Md.)Metabolomic profiles and childhood obesity. Obesity (Silver Spring). 2014 Dec; 22(12):2570-8.Obesity (Silver Spring)2014-09-24T00:00:002014Metabolomic profiles and childhood obesity.Authorship 246333Authorship 4970551Authorship 4477255Authorship 5229313Authorship 5378021Authorship 615981Authorship 4052006Authorship 3567685Authorship 4559234Authorship 5183771Authorship 6076612Authorship 4244166Authorship 1701468Authorship 1845492Authorship 5715252Authorship 3197887Authorship 35269516Authorship 3648909Authorship 1212282Authorship 3339081Authorship 3252281Authorship 2445195Authorship 26663611Authorship 3692546Authorship 3996475Authorship 40701812Authorship 4558261Authorship 7955586Authorship 7902919Authorship 8049577Authorship 7952295Authorship 79683111Authorship 7953431Authorship 796263725187365Robertson RP, Bogachus LD, Oseid E, Parazzoli S, Patti ME, Rickels MR, Schuetz C, Dunn T, Pruett T, Balamurugan AN, Sutherland DE, Beilman G, Bellin MDDiabetesAssessment of ß-cell mass and a- and ß-cell survival and function by arginine stimulation in human autologous islet recipients. Diabetes. 2015 Feb; 64(2):565-72.Diabetes2014-09-03T00:00:002014Assessment of ß-cell mass and a- and ß-cell survival and function by arginine stimulation in human autologous islet recipients.25811318Balhara B, Burkart A, Topcu V, Lee YK, Cowan C, Kahn CR, Patti MEEndocrinologySevere insulin resistance alters metabolism in mesenchymal progenitor cells. Endocrinology. 2015 Jun; 156(6):2039-48.Endocrinology2015-03-26T00:00:002015Severe insulin resistance alters metabolism in mesenchymal progenitor cells.25755084Patti ME, Li P, Goldfine ABObesity (Silver Spring, Md.)Insulin response to oral stimuli and glucose effectiveness increased in neuroglycopenia following gastric bypass. Obesity (Silver Spring). 2015 Apr; 23(4):798-807.Obesity (Silver Spring)2015-03-07T00:00:002015Insulin response to oral stimuli and glucose effectiveness increased in neuroglycopenia following gastric bypass.25631626Hivert MF, Perng W, Watkins SM, Newgard CS, Kenny LC, Kristal BS, Patti ME, Isganaitis E, DeMeo DL, Oken E, Gillman MWJournal of developmental origins of health and diseaseMetabolomics in the developmental origins of obesity and its cardiometabolic consequences. J Dev Orig Health Dis. 2015 Apr; 6(2):65-78.J Dev Orig Health Dis2015-01-29T00:00:002015Metabolomics in the developmental origins of obesity and its cardiometabolic consequences.25737951Nogiec C, Burkart A, Dreyfuss JM, Lerin C, Kasif S, Patti MEMolecular metabolismMetabolic modeling of muscle metabolism identifies key reactions linked to insulin resistance phenotypes. Mol Metab. 2015 Mar; 4(3):151-63.Mol Metab2015-01-02T00:00:002015Metabolic modeling of muscle metabolism identifies key reactions linked to insulin resistance phenotypes.25091727Beauchamp B, Ghosh S, Dysart MW, Kanaan GN, Chu A, Blais A, Rajamanickam K, Tsai EC, Patti ME, Harper MEInternational journal of obesity (2005)Low birth weight is associated with adiposity, impaired skeletal muscle energetics and weight loss resistance in mice. Int J Obes (Lond). 2015 Apr; 39(4):702-11.Int J Obes (Lond)2014-07-11T00:00:002014Low birth weight is associated with adiposity, impaired skeletal muscle energetics and weight loss resistance in mice.25569702McAninch EA, Jo S, Preite NZ, Farkas E, Mohácsik P, Fekete C, Egri P, Gereben B, Li Y, Deng Y, Patti ME, Zevenbergen C, Peeters RP, Mash DC, Bianco ACThe Journal of clinical endocrinology and metabolismPrevalent polymorphism in thyroid hormone-activating enzyme leaves a genetic fingerprint that underlies associated clinical syndromes. J Clin Endocrinol Metab. 2015 Mar; 100(3):920-33.J Clin Endocrinol Metab2015-01-08T00:00:002015Prevalent polymorphism in thyroid hormone-activating enzyme leaves a genetic fingerprint that underlies associated clinical syndromes.Authorship 300791826106230Middelbeek RJ, James-Todd T, Cavallerano JD, Schlossman DK, Patti ME, Brown FMDiabetes careGastric Bypass Surgery in Severely Obese Women With Type 1 Diabetes: Anthropometric and Cardiometabolic Effects at 1 and 5 Years Postsurgery. Diabetes Care. 2015 Jul; 38(7):e104-5.Diabetes Care2015-07-01T00:00:002015Gastric Bypass Surgery in Severely Obese Women With Type 1 Diabetes: Anthropometric and Cardiometabolic Effects at 1 and 5 Years Postsurgery.Authorship 4121992Authorship 5015081Authorship 8080995Authorship 35754510Authorship 814627725804930Isganaitis E, Rifas-Shiman SL, Oken E, Dreyfuss JM, Gall W, Gillman MW, Patti MEInternational journal of obesity (2005)Associations of cord blood metabolites with early childhood obesity risk. Int J Obes (Lond). 2015 Jul; 39(7):1041-8.Int J Obes (Lond)2015-03-25T00:00:002015Associations of cord blood metabolites with early childhood obesity risk.Authorship 2919991Authorship 815436726182362Beauchamp B, Thrush AB, Quizi J, Antoun G, McIntosh N, Al-Dirbashi OY, Patti ME, Harper MEBioscience reportsUndernutrition during pregnancy in mice leads to dysfunctional cardiac muscle respiration in adult offspring. Biosci Rep. 2015 Apr 10; 35(3).Biosci Rep2015-04-10T00:00:002015Undernutrition during pregnancy in mice leads to dysfunctional cardiac muscle respiration in adult offspring.Authorship 3809301023459395Sales V, Patti MECurrent cardiovascular risk reportsThe Ups and Downs of Insulin Resistance and Type 2 Diabetes: Lessons from Genomic Analyses in Humans. Curr Cardiovasc Risk Rep. 2013 Feb 01; 7(1):46-59.Curr Cardiovasc Risk Rep2012-12-09T00:00:002012The Ups and Downs of Insulin Resistance and Type 2 Diabetes: Lessons from Genomic Analyses in Humans.Authorship 5581308Authorship 5609639Authorship 837487226348724Goldfine AB, Patti MEObesity (Silver Spring, Md.)New lessons from gastric bypass: Impact of glucose-independent islet function. Obesity (Silver Spring). 2015 Oct; 23(10):1942-3.Obesity (Silver Spring)2015-09-08T00:00:002015New lessons from gastric bypass: Impact of glucose-independent islet function.Authorship 384572Authorship 4108721Authorship 4356891Authorship 5026907Authorship 487252626691888Makimura H, Stanley TL, Suresh C, De Sousa-Coelho AL, Frontera WR, Syu S, Braun LR, Looby SE, Feldpausch MN, Torriani M, Lee H, Patti ME, Grinspoon SKThe Journal of clinical endocrinology and metabolismMetabolic Effects of Long-Term Reduction in Free Fatty Acids With Acipimox in Obesity: A Randomized Trial. J Clin Endocrinol Metab. 2016 Mar; 101(3):1123-33.J Clin Endocrinol Metab2015-12-21T00:00:002015Metabolic Effects of Long-Term Reduction in Free Fatty Acids With Acipimox in Obesity: A Randomized Trial.Authorship 8669271Authorship 8682344Authorship 8651856Authorship 86856712Authorship 870322726831110Iovino S, Burkart AM, Warren L, Patti ME, Kahn CRProceedings of the National Academy of Sciences of the United States of AmericaMyotubes derived from human-induced pluripotent stem cells mirror in vivo insulin resistance. Proc Natl Acad Sci U S A. 2016 Feb 16; 113(7):1889-94.Proc Natl Acad Sci U S A2016-02-01T00:00:002016Myotubes derived from human-induced pluripotent stem cells mirror in vivo insulin resistance.26948272Burkart AM, Tan K, Warren L, Iovino S, Hughes KJ, Kahn CR, Patti MEScientific reportsInsulin Resistance in Human iPS Cells Reduces Mitochondrial Size and Function. Sci Rep. 2016 Mar 07; 6:22788.Sci Rep2016-03-07T00:00:002016Insulin Resistance in Human iPS Cells Reduces Mitochondrial Size and Function.25039984Bellin MD, Parazzoli S, Oseid E, Bogachus LD, Schuetz C, Patti ME, Dunn T, Pruett T, Balamurugan AN, Hering B, Beilman G, Sutherland DE, Robertson RPAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant SurgeonsDefective glucagon secretion during hypoglycemia after intrahepatic but not nonhepatic islet autotransplantation. Am J Transplant. 2014 Aug; 14(8):1880-6.Am J Transplant2014-08-01T00:00:002014Defective glucagon secretion during hypoglycemia after intrahepatic but not nonhepatic islet autotransplantation.26701701Patti ME, Goldfine ABThe lancet. Diabetes & endocrinologyThe rollercoaster of post-bariatric hypoglycaemia. Lancet Diabetes Endocrinol. 2016 Feb; 4(2):94-6.Lancet Diabetes Endocrinol2015-12-15T00:00:002015The rollercoaster of post-bariatric hypoglycaemia.Authorship 875061726846121Mulla CM, Storino A, Yee EU, Lautz D, Sawnhey MS, Moser AJ, Patti MEObesity surgeryInsulinoma After Bariatric Surgery: Diagnostic Dilemma and Therapeutic Approaches. Obes Surg. 2016 Apr; 26(4):874-81.Obes Surg2016-04-01T00:00:002016Insulinoma After Bariatric Surgery: Diagnostic Dilemma and Therapeutic Approaches.Authorship 4722423Authorship 493669227192680Middelbeek RJ, Brown FM, Patti METhe New England journal of medicineWeight Loss and Health Status after Bariatric Surgery in Adolescents. N Engl J Med. 2016 05 19; 374(20):1988-9.N Engl J Med2016-05-19T00:00:002016Weight Loss and Health Status after Bariatric Surgery in Adolescents.Authorship 8808143Authorship 8839462Authorship 8840051627225595Goldfine AB, Patti MEObesity (Silver Spring, Md.)How common is hypoglycemia after gastric bypass? Obesity (Silver Spring). 2016 06; 24(6):1210-1.Obesity (Silver Spring)2016-06-01T00:00:002016How common is hypoglycemia after gastric bypass?26858359Ejaz A, Martinez-Guino L, Goldfine AB, Ribas-Aulinas F, De Nigris V, Ribó S, Gonzalez-Franquesa A, Garcia-Roves PM, Li E, Dreyfuss JM, Gall W, Kim JK, Bottiglieri T, Villarroya F, Gerszten RE, Patti ME, Lerin CDiabetesDietary Betaine Supplementation Increases Fgf21 Levels to Improve Glucose Homeostasis and Reduce Hepatic Lipid Accumulation in Mice. Diabetes. 2016 04; 65(4):902-12.Diabetes2016-02-08T00:00:002016Dietary Betaine Supplementation Increases Fgf21 Levels to Improve Glucose Homeostasis and Reduce Hepatic Lipid Accumulation in Mice.Authorship 888755427319324Gonzalez-Franquesa A, Burkart AM, Isganaitis E, Patti MECurrent diabetes reportsWhat Have Metabolomics Approaches Taught Us About Type 2 Diabetes? Curr Diab Rep. 2016 08; 16(8):74.Curr Diab Rep2016-08-01T00:00:002016What Have Metabolomics Approaches Taught Us About Type 2 Diabetes?2Assistant Professor1Associate Professor6Fellow or Post Doc0Full Professor4Instructor5Other FacultyAuthorship 6773310SO113SoravisOsataphanSoravis Osataphan, M.D.151342Osataphan, SoravisClinical Fellow in MedicineAuthorship 9182211727689005Lerin C, Goldfine AB, Boes T, Liu M, Kasif S, Dreyfuss JM, De Sousa-Coelho AL, Daher G, Manoli I, Sysol JR, Isganaitis E, Jessen N, Goodyear LJ, Beebe K, Gall W, Venditti CP, Patti MEMolecular metabolismDefects in muscle branched-chain amino acid oxidation contribute to impaired lipid metabolism. Mol Metab. 2016 Oct; 5(10):926-936.Mol Metab2016-08-06T00:00:002016Defects in muscle branched-chain amino acid oxidation contribute to impaired lipid metabolism.Authorship 9262892Authorship 928491Authorship 928855827531045Costa SM, Isganaitis E, Matthews TJ, Hughes K, Daher G, Dreyfuss JM, da Silva GA, Patti MEInternational journal of obesity (2005)Maternal obesity programs mitochondrial and lipid metabolism gene expression in infant umbilical vein endothelial cells. Int J Obes (Lond). 2016 11; 40(11):1627-1634.Int J Obes (Lond)2016-08-17T00:00:002016Maternal obesity programs mitochondrial and lipid metabolism gene expression in infant umbilical vein endothelial cells.27770180Diabetologia40th EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004. Diabetologia. 2004 Aug; 47(Suppl 1):A1-A464.Diabetologia2004-08-01T00:00:00200440th EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004.Authorship 5805813Authorship 38614712Authorship 5097728Authorship 9572672625960695Pihlajamäki J, Lerin C, Kaminska D, Venesmaa S, Itkonen P, Boes T, Floss T, Schroeder J, Dearie F, Crunkhorn S, Burak F, Jimenez-Chillaron JC, Kuulasmaa T, Miettinen P, Park PJ, Nasser I, Zhao Z, Zhang Z, Xu Y, Wurst W, Ren H, Morris AJ, Stamm S, Goldfine AB, Laakso M, Patti MECell metabolismResponse to Brosch et al. Cell Metab. 2012 Mar 07; 15(3):267-269.Cell Metab2012-03-07T00:00:002012Response to Brosch et al.8927042Goldfine AB, Simonson DC, Folli F, Patti ME, Kahn CRMolecular and cellular biochemistryIn vivo and in vitro studies of vanadate in human and rodent diabetes mellitus. Mol Cell Biochem. 1995 Dec 6-20; 153(1-2):217-31.Mol Cell Biochem1995-12-01T00:00:001995In vivo and in vitro studies of vanadate in human and rodent diabetes mellitus.Authorship 964973725860649Beauchamp B, Thrush AB, Quizi J, Antoun G, McIntosh N, Al-Dirbashi OY, Patti ME, Harper MEBioscience reportsUndernutrition during pregnancy in mice leads to dysfunctional cardiac muscle respiration in adult offspring. Biosci Rep. 2015 Apr 10.Biosci Rep2015-04-10T00:00:002015Undernutrition during pregnancy in mice leads to dysfunctional cardiac muscle respiration in adult offspring.10426374Patti ME, Virkamäki A, Landaker EJ, Kahn CR, Yki-Järvinen HDiabetesActivation of the hexosamine pathway by glucosamine in vivo induces insulin resistance of early postreceptor insulin signaling events in skeletal muscle. Diabetes. 1999 Aug; 48(8):1562-71.Diabetes1999-08-01T00:00:001999Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance of early postreceptor insulin signaling events in skeletal muscle.Authorship 969032328273478Sales VM, Ferguson-Smith AC, Patti MECell metabolismEpigenetic Mechanisms of Transmission of Metabolic Disease across Generations. Cell Metab. 2017 03 07; 25(3):559-571.Cell Metab2017-03-07T00:00:002017Epigenetic Mechanisms of Transmission of Metabolic Disease across Generations.19036883Grozovsky R, Ribich S, Rosene ML, Mulcahey MA, Huang SA, Patti ME, Bianco AC, Kim BWEndocrinologyType 2 deiodinase expression is induced by peroxisomal proliferator-activated receptor-gamma agonists in skeletal myocytes. Endocrinology. 2009 Apr; 150(4):1976-83.Endocrinology2008-11-26T00:00:002008Type 2 deiodinase expression is induced by peroxisomal proliferator-activated receptor-gamma agonists in skeletal myocytes.19906680Espinoza DO, Boros LG, Crunkhorn S, Gami H, Patti MEFASEB journal : official publication of the Federation of American Societies for Experimental BiologyDual modulation of both lipid oxidation and synthesis by peroxisome proliferator-activated receptor-gamma coactivator-1alpha and -1beta in cultured myotubes. FASEB J. 2010 Apr; 24(4):1003-14.FASEB J2009-11-11T00:00:002009Dual modulation of both lipid oxidation and synthesis by peroxisome proliferator-activated receptor-gamma coactivator-1alpha and -1beta in cultured myotubes.15192439Patti MECurrent opinion in clinical nutrition and metabolic careGene expression in humans with diabetes and prediabetes: what have we learned about diabetes pathophysiology? Curr Opin Clin Nutr Metab Care. 2004 Jul; 7(4):383-90.Curr Opin Clin Nutr Metab Care2004-07-01T00:00:002004Gene expression in humans with diabetes and prediabetes: what have we learned about diabetes pathophysiology?10212828Patti ME, Kahn CRJournal of basic and clinical physiology and pharmacologyThe insulin receptor--a critical link in glucose homeostasis and insulin action. J Basic Clin Physiol Pharmacol. 1998; 9(2-4):89-109.J Basic Clin Physiol Pharmacol1998-01-01T00:00:001998The insulin receptor--a critical link in glucose homeostasis and insulin action.15546994Yechoor VK, Patti ME, Ueki K, Laustsen PG, Saccone R, Rauniyar R, Kahn CRProceedings of the National Academy of Sciences of the United States of AmericaDistinct pathways of insulin-regulated versus diabetes-regulated gene expression: an in vivo analysis in MIRKO mice. Proc Natl Acad Sci U S A. 2004 Nov 23; 101(47):16525-30.Proc Natl Acad Sci U S A2004-11-16T00:00:002004Distinct pathways of insulin-regulated versus diabetes-regulated gene expression: an in vivo analysis in MIRKO mice.Authorship 976885428392017Suhl E, Anderson-Haynes SE, Mulla C, Patti MESurgery for obesity and related diseases : official journal of the American Society for Bariatric SurgeryMedical nutrition therapy for post-bariatric hypoglycemia: practical insights. Surg Obes Relat Dis. 2017 May; 13(5):888-896.Surg Obes Relat Dis2017-01-16T00:00:002017Medical nutrition therapy for post-bariatric hypoglycemia: practical insights.12142560Fraenkel PG, Rutkove SB, Matheson JK, Fowkes M, Cannon ME, Patti ME, Atkins MB, Gollob JAJournal of immunotherapy (Hagerstown, Md. : 1997)Induction of myasthenia gravis, myositis, and insulin-dependent diabetes mellitus by high-dose interleukin-2 in a patient with renal cell cancer. J Immunother. 2002 Jul-Aug; 25(4):373-8.J Immunother2002-07-01T00:00:002002Induction of myasthenia gravis, myositis, and insulin-dependent diabetes mellitus by high-dose interleukin-2 in a patient with renal cell cancer.9525995Patti ME, Brambilla E, Luzi L, Landaker EJ, Kahn CRThe Journal of clinical investigationBidirectional modulation of insulin action by amino acids. J Clin Invest. 1998 Apr 01; 101(7):1519-29.J Clin Invest1998-04-01T00:00:001998Bidirectional modulation of insulin action by amino acids.One Joslin PlaceJoslin Diabetes CenterCellular & Mol. PhysiologyOne Joslin PlaceBoston02215MA10842663Patti MEAnnals of the New York Academy of SciencesNutrient modulation of cellular insulin action. Ann N Y Acad Sci. 1999 Nov 18; 892:187-203.Ann N Y Acad Sci1999-11-18T00:00:001999Nutrient modulation of cellular insulin action.16761107Jimenez-Chillaron JC, Hernandez-Valencia M, Lightner A, Faucette RR, Reamer C, Przybyla R, Ruest S, Barry K, Otis JP, Patti MEDiabetologiaReductions in caloric intake and early postnatal growth prevent glucose intolerance and obesity associated with low birthweight. Diabetologia. 2006 Aug; 49(8):1974-84.Diabetologia2006-06-08T00:00:002006Reductions in caloric intake and early postnatal growth prevent glucose intolerance and obesity associated with low birthweight.10416561Koval JA, Maezono K, Patti ME, Pendergrass M, DeFronzo RA, Mandarino LJMedicine and science in sports and exerciseEffects of exercise and insulin on insulin signaling proteins in human skeletal muscle. Med Sci Sports Exerc. 1999 Jul; 31(7):998-1004.Med Sci Sports Exerc1999-07-01T00:00:001999Effects of exercise and insulin on insulin signaling proteins in human skeletal muscle.Authorship 981039128512677Patti ME, Goldfine AB, Hu J, Hoem D, Molven A, Goldsmith J, Schwesinger WH, La Rosa S, Folli F, Kulkarni RNActa diabetologicaHeterogeneity of proliferative markers in pancreatic ß-cells of patients with severe hypoglycemia following Roux-en-Y gastric bypass. Acta Diabetol. 2017 Aug; 54(8):737-747.Acta Diabetol2017-05-17T00:00:002017Heterogeneity of proliferative markers in pancreatic ß-cells of patients with severe hypoglycemia following Roux-en-Y gastric bypass.10726921Goldfine AB, Patti ME, Zuberi L, Goldstein BJ, LeBlanc R, Landaker EJ, Jiang ZY, Willsky GR, Kahn CRMetabolism: clinical and experimentalMetabolic effects of vanadyl sulfate in humans with non-insulin-dependent diabetes mellitus: in vivo and in vitro studies. Metabolism. 2000 Mar; 49(3):400-10.Metabolism2000-03-01T00:00:002000Metabolic effects of vanadyl sulfate in humans with non-insulin-dependent diabetes mellitus: in vivo and in vitro studies.18762020Doria A, Patti ME, Kahn CRCell metabolismThe emerging genetic architecture of type 2 diabetes. Cell Metab. 2008 Sep; 8(3):186-200.Cell Metab2008-09-01T00:00:002008The emerging genetic architecture of type 2 diabetes.20660060Hall JA, Ribich S, Christoffolete MA, Simovic G, Correa-Medina M, Patti ME, Bianco ACEndocrinologyAbsence of thyroid hormone activation during development underlies a permanent defect in adaptive thermogenesis. Endocrinology. 2010 Sep; 151(9):4573-82.Endocrinology2010-07-21T00:00:002010Absence of thyroid hormone activation during development underlies a permanent defect in adaptive thermogenesis.16091909Halperin F, Beckman JA, Patti ME, Trujillo ME, Garvin M, Creager MA, Scherer PE, Goldfine ABDiabetologiaThe role of total and high-molecular-weight complex of adiponectin in vascular function in offspring whose parents both had type 2 diabetes. Diabetologia. 2005 Oct; 48(10):2147-54.Diabetologia2005-08-10T00:00:002005The role of total and high-molecular-weight complex of adiponectin in vascular function in offspring whose parents both had type 2 diabetes.16166232Myers MG, Patti ME, Leshan RLEndocrinologyHitting the target: leptin and perinatal nutrition in the predisposition to obesity. Endocrinology. 2005 Oct; 146(10):4209-10.Endocrinology2005-10-01T00:00:002005Hitting the target: leptin and perinatal nutrition in the predisposition to obesity.Authorship 984913228551803Gonzalez-Franquesa A, Patti MEAdvances in experimental medicine and biologyInsulin Resistance and Mitochondrial Dysfunction. Adv Exp Med Biol. 2017; 982:465-520.Adv Exp Med Biol2017-01-01T00:00:002017Insulin Resistance and Mitochondrial Dysfunction.17363743Arikawa E, Ma RC, Isshiki K, Luptak I, He Z, Yasuda Y, Maeno Y, Patti ME, Weir GC, Harris RA, Zammit VA, Tian R, King GLDiabetesEffects of insulin replacements, inhibitors of angiotensin, and PKCbeta's actions to normalize cardiac gene expression and fuel metabolism in diabetic rats. Diabetes. 2007 May; 56(5):1410-20.Diabetes2007-03-15T00:00:002007Effects of insulin replacements, inhibitors of angiotensin, and PKCbeta's actions to normalize cardiac gene expression and fuel metabolism in diabetic rats.9204876Smith-Hall J, Pons S, Patti ME, Burks DJ, Yenush L, Sun XJ, Kahn CR, White MFBiochemistryThe 60 kDa insulin receptor substrate functions like an IRS protein (pp60IRS3) in adipose cells. Biochemistry. 1997 Jul 08; 36(27):8304-10.Biochemistry1997-07-08T00:00:001997The 60 kDa insulin receptor substrate functions like an IRS protein (pp60IRS3) in adipose cells.Authorship 9918881428637315Ma H, Sales VM, Wolf AR, Subramanian S, Matthews TJ, Chen M, Sharma A, Gall W, Kulik W, Cohen DE, Adachi Y, Griffin NW, Gordon JI, Patti ME, Isganaitis EEndocrinologyAttenuated Effects of Bile Acids on Glucose Metabolism and Insulin Sensitivity in a Male Mouse Model of Prenatal Undernutrition. Endocrinology. 2017 08 01; 158(8):2441-2452.Endocrinology2017-08-01T00:00:002017Attenuated Effects of Bile Acids on Glucose Metabolism and Insulin Sensitivity in a Male Mouse Model of Prenatal Undernutrition.12149437Yechoor VK, Patti ME, Saccone R, Kahn CRProceedings of the National Academy of Sciences of the United States of AmericaCoordinated patterns of gene expression for substrate and energy metabolism in skeletal muscle of diabetic mice. Proc Natl Acad Sci U S A. 2002 Aug 06; 99(16):10587-92.Proc Natl Acad Sci U S A2002-07-29T00:00:002002Coordinated patterns of gene expression for substrate and energy metabolism in skeletal muscle of diabetic mice.15756215Gordon LB, Harten IA, Patti ME, Lichtenstein AHThe Journal of pediatricsReduced adiponectin and HDL cholesterol without elevated C-reactive protein: clues to the biology of premature atherosclerosis in Hutchinson-Gilford Progeria Syndrome. J Pediatr. 2005 Mar; 146(3):336-41.J Pediatr2005-03-01T00:00:002005Reduced adiponectin and HDL cholesterol without elevated C-reactive protein: clues to the biology of premature atherosclerosis in Hutchinson-Gilford Progeria Syndrome.16781373Goldfine AB, Beckman JA, Betensky RA, Devlin H, Hurley S, Varo N, Schonbeck U, Patti ME, Creager MAJournal of the American College of CardiologyFamily history of diabetes is a major determinant of endothelial function. J Am Coll Cardiol. 2006 Jun 20; 47(12):2456-61.J Am Coll Cardiol2006-05-30T00:00:002006Family history of diabetes is a major determinant of endothelial function.16971218Hernandez-Valencia M, Patti MEArchives of medical researchA thin phenotype is protective for impaired glucose tolerance and related to low birth weight in mice. Arch Med Res. 2006 Oct; 37(7):813-7.Arch Med Res2006-10-01T00:00:002006A thin phenotype is protective for impaired glucose tolerance and related to low birth weight in mice.18713797Ruddock MW, Stein A, Landaker E, Park J, Cooksey RC, McClain D, Patti MEJournal of biochemistrySaturated fatty acids inhibit hepatic insulin action by modulating insulin receptor expression and post-receptor signalling. J Biochem. 2008 Nov; 144(5):599-607.J Biochem2008-08-19T00:00:002008Saturated fatty acids inhibit hepatic insulin action by modulating insulin receptor expression and post-receptor signalling.20406106Castillo M, Freitas BC, Rosene ML, Drigo RA, Grozovsky R, Maciel RM, Patti ME, Ribeiro MO, Bianco ACThyroid : official journal of the American Thyroid AssociationImpaired metabolic effects of a thyroid hormone receptor beta-selective agonist in a mouse model of diet-induced obesity. Thyroid. 2010 May; 20(5):545-53.Thyroid2010-05-01T00:00:002010Impaired metabolic effects of a thyroid hormone receptor beta-selective agonist in a mouse model of diet-induced obesity.21284975Ferguson-Smith AC, Patti MECell metabolismYou are what your dad ate. Cell Metab. 2011 Feb 02; 13(2):115-7.Cell Metab2011-02-02T00:00:002011You are what your dad ate.Authorship 1008968328868615Mulla CM, Middelbeek RJW, Patti MEAnnals of the New York Academy of SciencesMechanisms of weight loss and improved metabolism following bariatric surgery. Ann N Y Acad Sci. 2018 01; 1411(1):53-64.Ann N Y Acad Sci2017-09-03T00:00:002017Mechanisms of weight loss and improved metabolism following bariatric surgery.16195867Patti ME, McMahon G, Mun EC, Bitton A, Holst JJ, Goldsmith J, Hanto DW, Callery M, Arky R, Nose V, Bonner-Weir S, Goldfine ABDiabetologiaSevere hypoglycaemia post-gastric bypass requiring partial pancreatectomy: evidence for inappropriate insulin secretion and pancreatic islet hyperplasia. Diabetologia. 2005 Nov; 48(11):2236-40.Diabetologia2005-09-30T00:00:002005Severe hypoglycaemia post-gastric bypass requiring partial pancreatectomy: evidence for inappropriate insulin secretion and pancreatic islet hyperplasia.19396065Apovian CM, Cummings S, Anderson W, Borud L, Boyer K, Day K, Hatchigian E, Hodges B, Patti ME, Pettus M, Perna F, Rooks D, Saltzman E, Skoropowski J, Tantillo MB, Thomason PObesity (Silver Spring, Md.)Best practice updates for multidisciplinary care in weight loss surgery. Obesity (Silver Spring). 2009 May; 17(5):871-9.Obesity (Silver Spring)2009-02-19T00:00:002009Best practice updates for multidisciplinary care in weight loss surgery.11571328Rosas HD, Goodman J, Chen YI, Jenkins BG, Kennedy DN, Makris N, Patti M, Seidman LJ, Beal MF, Koroshetz WJNeurologyStriatal volume loss in HD as measured by MRI and the influence of CAG repeat. Neurology. 2001 Sep 25; 57(6):1025-8.Neurology2001-09-25T00:00:002001Striatal volume loss in HD as measured by MRI and the influence of CAG repeat.16757574Tiffin N, Adie E, Turner F, Brunner HG, van Driel MA, Oti M, Lopez-Bigas N, Ouzounis C, Perez-Iratxeta C, Andrade-Navarro MA, Adeyemo A, Patti ME, Semple CA, Hide WNucleic acids researchComputational disease gene identification: a concert of methods prioritizes type 2 diabetes and obesity candidate genes. Nucleic Acids Res. 2006; 34(10):3067-81.Nucleic Acids Res2006-06-06T00:00:002006Computational disease gene identification: a concert of methods prioritizes type 2 diabetes and obesity candidate genes.17370059Oge A, Isganaitis E, Jimenez-Chillaron J, Reamer C, Faucette R, Barry K, Przybyla R, Patti MEDiabetologiaIn utero undernutrition reduces diabetes incidence in non-obese diabetic mice. Diabetologia. 2007 May; 50(5):1099-108.Diabetologia2007-03-17T00:00:002007In utero undernutrition reduces diabetes incidence in non-obese diabetic mice.12540596Combs TP, Berg AH, Rajala MW, Klebanov S, Iyengar P, Jimenez-Chillaron JC, Patti ME, Klein SL, Weinstein RS, Scherer PEDiabetesSexual differentiation, pregnancy, calorie restriction, and aging affect the adipocyte-specific secretory protein adiponectin. Diabetes. 2003 Feb; 52(2):268-76.Diabetes2003-02-01T00:00:002003Sexual differentiation, pregnancy, calorie restriction, and aging affect the adipocyte-specific secretory protein adiponectin.12832613Patti ME, Butte AJ, Crunkhorn S, Cusi K, Berria R, Kashyap S, Miyazaki Y, Kohane I, Costello M, Saccone R, Landaker EJ, Goldfine AB, Mun E, DeFronzo R, Finlayson J, Kahn CR, Mandarino LJProceedings of the National Academy of Sciences of the United States of AmericaCoordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1. Proc Natl Acad Sci U S A. 2003 Jul 08; 100(14):8466-71.Proc Natl Acad Sci U S A2003-06-27T00:00:002003Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1.15132881Patti MECurrent diabetes reportsGene expression in the pathophysiology of type 2 diabetes mellitus. Curr Diab Rep. 2004 Jun; 4(3):176-81.Curr Diab Rep2004-06-01T00:00:002004Gene expression in the pathophysiology of type 2 diabetes mellitus.Authorship 1019760129045187Patti MEEndocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical EndocrinologistsLETTER TO THE EDITOR. Endocr Pract. 2017 10; 23(10):1275.Endocr Pract2017-10-01T00:00:002017LETTER TO THE EDITOR.19008912Isshiki K, He Z, Maeno Y, Ma RC, Yasuda Y, Kuroki T, White GS, Patti ME, Weir GC, King GLKidney internationalInsulin regulates SOCS2 expression and the mitogenic effect of IGF-1 in mesangial cells. Kidney Int. 2008 Dec; 74(11):1434-43.Kidney Int2008-08-13T00:00:002008Insulin regulates SOCS2 expression and the mitogenic effect of IGF-1 in mesangial cells.19416713Wang XL, Suzuki R, Lee K, Tran T, Gunton JE, Saha AK, Patti ME, Goldfine A, Ruderman NB, Gonzalez FJ, Kahn CRCell metabolismAblation of ARNT/HIF1beta in liver alters gluconeogenesis, lipogenic gene expression, and serum ketones. Cell Metab. 2009 May; 9(5):428-39.Cell Metab2009-05-01T00:00:002009Ablation of ARNT/HIF1beta in liver alters gluconeogenesis, lipogenic gene expression, and serum ketones.20835917Reubi JC, Perren A, Rehmann R, Waser B, Christ E, Callery M, Goldfine AB, Patti MEDiabetologiaGlucagon-like peptide-1 (GLP-1) receptors are not overexpressed in pancreatic islets from patients with severe hyperinsulinaemic hypoglycaemia following gastric bypass. Diabetologia. 2010 Dec; 53(12):2641-5.Diabetologia2010-09-14T00:00:002010Glucagon-like peptide-1 (GLP-1) receptors are not overexpressed in pancreatic islets from patients with severe hyperinsulinaemic hypoglycaemia following gastric bypass.21237159da-Silva WS, Ribich S, Arrojo e Drigo R, Castillo M, Patti ME, Bianco ACFEBS lettersThe chemical chaperones tauroursodeoxycholic and 4-phenylbutyric acid accelerate thyroid hormone activation and energy expenditure. FEBS Lett. 2011 Feb 04; 585(3):539-44.FEBS Lett2011-01-14T00:00:002011The chemical chaperones tauroursodeoxycholic and 4-phenylbutyric acid accelerate thyroid hormone activation and energy expenditure.18406764Patti ME, Kahn CRTrends in endocrinology and metabolism: TEMLessons from transgenic and knockout animals about noninsulin-dependent diabetes mellitus. Trends Endocrinol Metab. 1996 Nov; 7(9):311-9.Trends Endocrinol Metab1996-11-01T00:00:001996Lessons from transgenic and knockout animals about noninsulin-dependent diabetes mellitus.7526222Araki E, Lipes MA, Patti ME, Brüning JC, Haag B, Johnson RS, Kahn CRNatureAlternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. Nature. 1994 Nov 10; 372(6502):186-90.Nature1994-11-10T00:00:001994Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.7593444Goldfine AB, Simonson DC, Folli F, Patti ME, Kahn CRThe Journal of clinical endocrinology and metabolismMetabolic effects of sodium metavanadate in humans with insulin-dependent and noninsulin-dependent diabetes mellitus in vivo and in vitro studies. J Clin Endocrinol Metab. 1995 Nov; 80(11):3311-20.J Clin Endocrinol Metab1995-11-01T00:00:001995Metabolic effects of sodium metavanadate in humans with insulin-dependent and noninsulin-dependent diabetes mellitus in vivo and in vitro studies.20156986Patti ME, Corvera SEndocrine reviewsThe role of mitochondria in the pathogenesis of type 2 diabetes. Endocr Rev. 2010 Jun; 31(3):364-95.Endocr Rev2010-02-15T00:00:002010The role of mitochondria in the pathogenesis of type 2 diabetes.21247245Woo M, Isganaitis E, Cerletti M, Fitzpatrick C, Wagers AJ, Jimenez-Chillaron J, Patti MEStem cells and developmentEarly life nutrition modulates muscle stem cell number: implications for muscle mass and repair. Stem Cells Dev. 2011 Oct; 20(10):1763-9.Stem Cells Dev2011-03-09T00:00:002011Early life nutrition modulates muscle stem cell number: implications for muscle mass and repair.21803291Pihlajamäki J, Lerin C, Itkonen P, Boes T, Floss T, Schroeder J, Dearie F, Crunkhorn S, Burak F, Jimenez-Chillaron JC, Kuulasmaa T, Miettinen P, Park PJ, Nasser I, Zhao Z, Zhang Z, Xu Y, Wurst W, Ren H, Morris AJ, Stamm S, Goldfine AB, Laakso M, Patti MECell metabolismExpression of the splicing factor gene SFRS10 is reduced in human obesity and contributes to enhanced lipogenesis. Cell Metab. 2011 Aug 03; 14(2):208-18.Cell Metab2011-08-03T00:00:002011Expression of the splicing factor gene SFRS10 is reduced in human obesity and contributes to enhanced lipogenesis.17940415Jimenez-Chillaron JC, Patti MECurrent opinion in endocrinology, diabetes, and obesityTo catch up or not to catch up: is this the question? Lessons from animal models. Curr Opin Endocrinol Diabetes Obes. 2007 Feb; 14(1):23-9.Curr Opin Endocrinol Diabetes Obes2007-02-01T00:00:002007To catch up or not to catch up: is this the question? Lessons from animal models.7559579Patti ME, Sun XJ, Bruening JC, Araki E, Lipes MA, White MF, Kahn CRThe Journal of biological chemistry4PS/insulin receptor substrate (IRS)-2 is the alternative substrate of the insulin receptor in IRS-1-deficient mice. J Biol Chem. 1995 Oct 20; 270(42):24670-3.J Biol Chem1995-10-20T00:00:0019954PS/insulin receptor substrate (IRS)-2 is the alternative substrate of the insulin receptor in IRS-1-deficient mice.20369014Zelezniak A, Pers TH, Soares S, Patti ME, Patil KRPLoS computational biologyMetabolic network topology reveals transcriptional regulatory signatures of type 2 diabetes. PLoS Comput Biol. 2010 Apr 01; 6(4):e1000729.PLoS Comput Biol2010-04-01T00:00:002010Metabolic network topology reveals transcriptional regulatory signatures of type 2 diabetes.JMD74JonathanDreyfussJonathan Michael Dreyfuss, Ph.D.165255Dreyfuss, JonathanInstructor in MedicineAuthorship 10370251529320745Fernandes GW, Bocco BMLC, Fonseca TL, McAninch EA, Jo S, Lartey LJ, O-Sullivan I, Unterman TG, Preite NZ, Voigt RM, Forsyth CB, Keshavarzian A, Sinkó R, Goldfine AB, Patti ME, Ribeiro MO, Gereben B, Bianco ACCell reportsThe Foxo1-Inducible Transcriptional Repressor Zfp125 Causes Hepatic Steatosis and Hypercholesterolemia. Cell Rep. 2018 01 09; 22(2):523-534.Cell Rep2018-01-09T00:00:002018The Foxo1-Inducible Transcriptional Repressor Zfp125 Causes Hepatic Steatosis and Hypercholesterolemia.20664166Patti METhe Journal of clinical investigationRehashing endocannabinoid antagonists: can we selectively target the periphery to safely treat obesity and type 2 diabetes? J Clin Invest. 2010 Aug; 120(8):2646-8.J Clin Invest2010-07-26T00:00:002010Rehashing endocannabinoid antagonists: can we selectively target the periphery to safely treat obesity and type 2 diabetes?21393865Jin W, Goldfine AB, Boes T, Henry RR, Ciaraldi TP, Kim EY, Emecan M, Fitzpatrick C, Sen A, Shah A, Mun E, Vokes V, Schroeder J, Tatro E, Jimenez-Chillaron J, Patti METhe Journal of clinical investigationIncreased SRF transcriptional activity in human and mouse skeletal muscle is a signature of insulin resistance. J Clin Invest. 2011 Mar; 121(3):918-29.J Clin Invest2011-03-01T00:00:002011Increased SRF transcriptional activity in human and mouse skeletal muscle is a signature of insulin resistance.21576825Bezy O, Tran TT, Pihlajamäki J, Suzuki R, Emanuelli B, Winnay J, Mori MA, Haas J, Biddinger SB, Leitges M, Goldfine AB, Patti ME, King GL, Kahn CRThe Journal of clinical investigationPKCd regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans. J Clin Invest. 2011 Jun; 121(6):2504-17.J Clin Invest2011-05-16T00:00:002011PKCd regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans.19076063Jin W, Patti MEClinical science (London, England : 1979)Genetic determinants and molecular pathways in the pathogenesis of Type 2 diabetes. Clin Sci (Lond). 2009 Jan; 116(2):99-111.Clin Sci (Lond)2009-01-01T00:00:002009Genetic determinants and molecular pathways in the pathogenesis of Type 2 diabetes.19208909Isganaitis E, Jimenez-Chillaron J, Woo M, Chow A, DeCoste J, Vokes M, Liu M, Kasif S, Zavacki AM, Leshan RL, Myers MG, Patti MEDiabetesAccelerated postnatal growth increases lipogenic gene expression and adipocyte size in low-birth weight mice. Diabetes. 2009 May; 58(5):1192-200.Diabetes2009-02-10T00:00:002009Accelerated postnatal growth increases lipogenic gene expression and adipocyte size in low-birth weight mice.19273596Sutherland AP, Zhang H, Zhang Y, Michaud M, Xie Z, Patti ME, Grusby MJ, Zhang WJMolecular and cellular biologyZinc finger protein Zbtb20 is essential for postnatal survival and glucose homeostasis. Mol Cell Biol. 2009 May; 29(10):2804-15.Mol Cell Biol2009-03-09T00:00:002009Zinc finger protein Zbtb20 is essential for postnatal survival and glucose homeostasis.Authorship 10269212Authorship 10433751429355439Laguna Sanz AJ, Mulla CM, Fowler KM, Cloutier E, Goldfine AB, Newswanger B, Cummins M, Deshpande S, Prestrelski SJ, Strange P, Zisser H, Doyle FJ, Dassau E, Patti MEDiabetes technology & therapeuticsDesign and Clinical Evaluation of a Novel Low-Glucose Prediction Algorithm with Mini-Dose Stable Glucagon Delivery in Post-Bariatric Hypoglycemia. 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