Harvard Catalyst Profiles

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Loren David Walensky, M.D.,Ph.D.

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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. T32GM144273 (WALENSKY, LOREN DAVID) Jul 1, 2022 - Jun 30, 2027
    NIH
    Medical Scientist Training Program
    Role: Principal Investigator
  2. R01CA233978 (WALES, THOMAS EDWARD) Dec 1, 2019 - Nov 30, 2024
    NIH
    Conformational Regulation and Therapeutic Targeting of Oncogenic KRAS
    Role: Co-Principal Investigator
  3. R21CA209358 (WALENSKY, LOREN DAVID) Jun 2, 2016 - May 31, 2018
    NIH
    Biophysical and Mechanistic Determinants for Cancer Cell Import of Hydrocarbon-Stapled Peptides
    Role: Principal Investigator
  4. R35CA197583 (WALENSKY, LOREN DAVID) Aug 10, 2015 - Jul 31, 2028
    NIH
    Dissecting and Targeting Deregulated Mitochondrial Apoptosis in Human Cancer
    Role: Principal Investigator
  5. R01CA195540 (WALENSKY, LOREN DAVID) Jul 1, 2015 - Jun 30, 2020
    NIH/NCI
    Negative Regulation of Apoptosis by the BH4 Domain of BCL-2 Proteins
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
Displaying 25 of 116 total Publications Show all
  1. Tang SX, Camara CM, Franco JA, Pazyra-Murphy MF, Li Y, Godes M, Moyer BM, Bird GH, Segal RA, Walensky LD. Dissecting the neuroprotective interaction between the BH4 domain of BCL-w and the IP3 receptor. Cell Chem Biol. 2024 Oct 17; 31(10):1815-1826.e5. PMID: 39067448; PMCID: PMC11490406.
    Citations:
    Fields: BioBiochemistryBioBiologyCheChemistryTranslation:AnimalsCells
  2. Mather RV, Rowell TR, Obuchowski S, Walensky LD. Dispelling the myth: comparable duration and impact of research training for MD-PhD and PhD graduates. JCI Insight. 2024 Jun 25; 9(15). PMID: 38917318; PMCID: PMC11383590.
    Citations:
    Fields: MedMedicine (General)Translation:Humans
  3. McHenry MW, Shi P, Camara CM, Cohen DT, Rettenmaier TJ, Adhikary U, Gygi MA, Yang K, Gygi SP, Wales TE, Engen JR, Wells JA, Walensky LD. Covalent inhibition of pro-apoptotic BAX. Nat Chem Biol. 2024 Aug; 20(8):1022-1032. PMID: 38233584; PMCID: PMC11252247.
    Citations: 4
    Fields: BioBiologyCheChemistryTranslation:HumansAnimalsCells
  4. Bird GH, Patten JJ, Zavadoski W, Barucci N, Godes M, Moyer BM, Owen CD, DaSilva-Jardine P, Neuberg DS, Bowen RA, Davey RA, Walensky LD. A stapled lipopeptide platform for preventing and treating highly pathogenic viruses of pandemic potential. Nat Commun. 2024 Jan 04; 15(1):274. PMID: 38177138; PMCID: PMC10766962.
    Citations:
    Fields: BioBiologySciScienceTranslation:HumansPHPublic Health
  5. Adhikary U, Paulo JA, Godes M, Roychoudhury S, Prew MS, Ben-Nun Y, Yu EW, Budhraja A, Opferman JT, Chowdhury D, Gygi SP, Walensky LD. Targeting MCL-1 triggers DNA damage and an anti-proliferative response independent from apoptosis induction. Cell Rep. 2023 10 31; 42(10):113176. PMID: 37773750; PMCID: PMC10787359.
    Citations: 3
    Fields: CelCell BiologyMolMolecular BiologyTranslation:Cells
  6. Larrayoz M, Garcia-Barchino MJ, Celay J, Etxebeste A, Jimenez M, Perez C, Ordoñez R, Cobaleda C, Botta C, Fresquet V, Roa S, Goicoechea I, Maia C, Lasaga M, Chesi M, Bergsagel PL, Larrayoz MJ, Calasanz MJ, Campos-Sanchez E, Martinez-Cano J, Panizo C, Rodriguez-Otero P, Vicent S, Roncador G, Gonzalez P, Takahashi S, Katz SG, Walensky LD, Ruppert SM, Lasater EA, Amann M, Lozano T, Llopiz D, Sarobe P, Lasarte JJ, Planell N, Gomez-Cabrero D, Kudryashova O, Kurilovich A, Revuelta MV, Cerchietti L, Agirre X, San Miguel J, Paiva B, Prosper F, Martinez-Climent JA. Preclinical models for prediction of immunotherapy outcomes and immune evasion mechanisms in genetically heterogeneous multiple myeloma. Nat Med. 2023 03; 29(3):632-645. PMID: 36928817; PMCID: PMC10033443.
    Citations: 19
    Fields: MedMedicine (General)MolMolecular BiologyTranslation:AnimalsCells
  7. Hawley KM, Eclov RJ, Schnorenberg MR, Tian Y, Shah RN, Thomas-Toth AT, Fefferman M, Bird GH, Walensky LD, Tirrell MV, LaBelle JL. Inhibition of FOXP3 by stapled alpha-helical peptides dampens regulatory T cell function. Proc Natl Acad Sci U S A. 2022 10 18; 119(42):e2209044119. PMID: 36227917; PMCID: PMC9586281.
    Citations: 6
    Fields: SciScienceTranslation:Cells
  8. Prew MS, Adhikary U, Choi DW, Portero EP, Paulo JA, Gowda P, Budhraja A, Opferman JT, Gygi SP, Danial NN, Walensky LD. MCL-1 is a master regulator of cancer dependency on fatty acid oxidation. Cell Rep. 2022 10 04; 41(1):111445. PMID: 36198266; PMCID: PMC9933948.
    Citations: 9
    Fields: CelCell BiologyMolMolecular BiologyTranslation:Cells
  9. Prew MS, Camara CM, Botzanowski T, Moroco JA, Bloch NB, Levy HR, Seo HS, Dhe-Paganon S, Bird GH, Herce HD, Gygi MA, Escudero S, Wales TE, Engen JR, Walensky LD. Structural basis for defective membrane targeting of mutant enzyme in human VLCAD deficiency. Nat Commun. 2022 06 27; 13(1):3669. PMID: 35760926; PMCID: PMC9237092.
    Citations: 3
    Fields: BioBiologySciScienceTranslation:Humans
  10. Levine PM, Craven TW, Li X, Balana AT, Bird GH, Godes M, Salveson PJ, Erickson PW, Lamb M, Ahlrichs M, Murphy M, Ogohara C, Said MY, Walensky LD, Pratt MR, Baker D. Generation of Potent and Stable GLP-1 Analogues Via "Serine Ligation". ACS Chem Biol. 2022 04 15; 17(4):804-809. PMID: 35319882; PMCID: PMC9173702.
    Citations: 2
    Fields: BioBiochemistryBioBiologyTranslation:Humans
  11. Saleh MN, Patel MR, Bauer TM, Goel S, Falchook GS, Shapiro GI, Chung KY, Infante JR, Conry RM, Rabinowits G, Hong DS, Wang JS, Steidl U, Walensky LD, Naik G, Guerlavais V, Vukovic V, Annis DA, Aivado M, Meric-Bernstam F. Correction: Phase I Trial of ALRN-6924, a Dual Inhibitor of MDMX and MDM2, in Patients with Solid Tumors and Lymphomas Bearing Wild-type TP53. Clin Cancer Res. 2022 Jan 15; 28(2):429. PMID: 35045962; PMCID: PMC10361214.
    Citations: 2
    Fields: NeoNeoplasms
  12. Fu A, van Rooyen L, Evans L, Armstrong N, Avizonis D, Kin T, Bird GH, Reddy A, Chouchani ET, Liesa-Roig M, Walensky LD, Shapiro AMJ, Danial NN. Glucose metabolism and pyruvate carboxylase enhance glutathione synthesis and restrict oxidative stress in pancreatic islets. Cell Rep. 2021 11 23; 37(8):110037. PMID: 34818536; PMCID: PMC8720303.
    Citations: 17
    Fields: CelCell BiologyMolMolecular BiologyTranslation:HumansAnimalsCells
  13. Bloch NB, Wales TE, Prew MS, Levy HR, Engen JR, Walensky LD. The conformational stability of pro-apoptotic BAX is dictated by discrete residues of the protein core. Nat Commun. 2021 08 13; 12(1):4932. PMID: 34389733; PMCID: PMC8363748.
    Citations: 8
    Fields: BioBiologySciScienceTranslation:HumansAnimalsCells
  14. Stocks BB, Bird GH, Walensky LD, Melanson JE. Characterizing Native and Hydrocarbon-Stapled Enfuvirtide Conformations with Ion Mobility Mass Spectrometry and Hydrogen-Deuterium Exchange. J Am Soc Mass Spectrom. 2021 Mar 03; 32(3):753-761. PMID: 33534566.
    Citations: 3
    Fields: CheChemistry Techniques, Analytic
  15. Fukuda Y, Pazyra-Murphy MF, Silagi ES, Tasdemir-Yilmaz OE, Li Y, Rose L, Yeoh ZC, Vangos NE, Geffken EA, Seo HS, Adelmant G, Bird GH, Walensky LD, Marto JA, Dhe-Paganon S, Segal RA. Binding and transport of SFPQ-RNA granules by KIF5A/KLC1 motors promotes axon survival. J Cell Biol. 2021 01 04; 220(1). PMID: 33284322; PMCID: PMC7721913.
    Citations: 30
    Fields: CelCell BiologyTranslation:HumansAnimalsCells
  16. Cathcart AM, Bird GH, Wales TE, Herce HD, Harvey EP, Hauseman ZJ, Newman CE, Adhikary U, Prew MS, Oo T, Lee S, Engen JR, Walensky LD. Targeting a helix-in-groove interaction between E1 and E2 blocks ubiquitin transfer. Nat Chem Biol. 2020 11; 16(11):1218-1226. PMID: 32807965.
    Citations: 4
    Fields: BioBiologyCheChemistryTranslation:HumansCells
  17. Korshavn KJ, Wales TE, Bird GH, Engen JR, Walensky LD. A redox switch regulates the structure and function of anti-apoptotic BFL-1. Nat Struct Mol Biol. 2020 09; 27(9):781-789. PMID: 32661419; PMCID: PMC7544158.
    Citations: 3
    Fields: MolMolecular BiologyTranslation:HumansAnimalsCells
  18. Hauseman ZJ, Harvey EP, Newman CE, Wales TE, Bucci JC, Mintseris J, Schweppe DK, David L, Fan L, Cohen DT, Herce HD, Mourtada R, Ben-Nun Y, Bloch NB, Hansen SB, Wu H, Gygi SP, Engen JR, Walensky LD. Homogeneous Oligomers of Pro-apoptotic BAX Reveal Structural Determinants of Mitochondrial Membrane Permeabilization. Mol Cell. 2020 07 02; 79(1):68-83.e7. PMID: 32533918; PMCID: PMC7472837.
    Citations: 18
    Fields: CelCell BiologyMolMolecular BiologyTranslation:HumansAnimalsCells
  19. Bird GH, Fu A, Escudero S, Godes M, Opoku-Nsiah K, Wales TE, Cameron MD, Engen JR, Danial NN, Walensky LD. Hydrocarbon-Stitched Peptide Agonists of Glucagon-Like Peptide-1 Receptor. ACS Chem Biol. 2020 06 19; 15(6):1340-1348. PMID: 32348108.
    Citations: 5
    Fields: BioBiochemistryBioBiologyTranslation:HumansAnimalsCells
  20. Harvey EP, Hauseman ZJ, Cohen DT, Rettenmaier TJ, Lee S, Huhn AJ, Wales TE, Seo HS, Luccarelli J, Newman CE, Guerra RM, Bird GH, Dhe-Paganon S, Engen JR, Wells JA, Walensky LD. Identification of a Covalent Molecular Inhibitor of Anti-apoptotic BFL-1 by Disulfide Tethering. Cell Chem Biol. 2020 06 18; 27(6):647-656.e6. PMID: 32413285; PMCID: PMC7405809.
    Citations: 12
    Fields: BioBiochemistryBioBiologyCheChemistryTranslation:HumansCells
  21. Fu A, Alvarez-Perez JC, Avizonis D, Kin T, Ficarro SB, Choi DW, Karakose E, Badur MG, Evans L, Rosselot C, Bridon G, Bird GH, Seo HS, Dhe-Paganon S, Kamphorst JJ, Stewart AF, James Shapiro AM, Marto JA, Walensky LD, Jones RG, Garcia-Ocana A, Danial NN. Glucose-dependent partitioning of arginine to the urea cycle protects ß-cells from inflammation. Nat Metab. 2020 05; 2(5):432-446. PMID: 32694660; PMCID: PMC7568475.
    Citations: 23
    Fields: MetMetabolismTranslation:HumansCells
  22. Ben-Nun Y, Seo HS, Harvey EP, Hauseman ZJ, Wales TE, Newman CE, Cathcart AM, Engen JR, Dhe-Paganon S, Walensky LD. Identification of a Structural Determinant for Selective Targeting of HDMX. Structure. 2020 07 07; 28(7):847-857.e5. PMID: 32359398; PMCID: PMC7427690.
    Citations:
    Fields: BioBiochemistryBioBiotechnologyMolMolecular BiologyTranslation:HumansCells
  23. Cohen DT, Wales TE, McHenry MW, Engen JR, Walensky LD. Site-Dependent Cysteine Lipidation Potentiates the Activation of Proapoptotic BAX. Cell Rep. 2020 03 10; 30(10):3229-3239.e6. PMID: 32160532; PMCID: PMC7343539.
    Citations: 14
    Fields: CelCell BiologyMolMolecular BiologyTranslation:HumansAnimalsCells
  24. Rowell TR, Redd RA, Neuberg DS, Walensky LD. Mind the gap: Expediting gender parity in MD-PhD admissions. JCI Insight. 2020 02 27; 5(4). PMID: 32102982.
    Citations: 4
    Fields: MedMedicine (General)Translation:Humans
  25. Mourtada R, Herce HD, Yin DJ, Moroco JA, Wales TE, Engen JR, Walensky LD. Design of stapled antimicrobial peptides that are stable, nontoxic and kill antibiotic-resistant bacteria in mice. Nat Biotechnol. 2019 10; 37(10):1186-1197. PMID: 31427820; PMCID: PMC7437984.
    Citations: 104
    Fields: BioBiotechnologyTranslation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.