Harvard Catalyst Profiles

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William Michael Oldham, M.D., Ph.D.

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Overview

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01HL167718 (OLDHAM, WILLIAM MICHAEL) Jun 5, 2023 - May 31, 2028
    NIH
    Role of lactate transporters in pulmonary fibrosis
    Role: Principal Investigator
  2. K08HL128802 (OLDHAM, WILLIAM MICHAEL) Apr 1, 2016 - Mar 31, 2021
    NIH
    Regulation of pulmonary vascular cell redox state by L-2-hydroxyglutarate
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
Displaying 25 of 72 total Publications Show all
  1. Oldham WM. Targeting Cardiac Fibrosis With a Vaccine Against Fibroblast Activation Protein. Circ Res. 2025 Jan 03; 136(1):41-43. PMID: 39745992; PMCID: PMC11698487.
    Citations:
    Fields: CarCardiologyVasVascular Diseases
  2. Nguyen HN, Jeong Y, Kim Y, Kamiya M, Kim Y, Athar H, Castaldi PJ, Hersh CP, Menon JA, Wong J, Chan I, Oldham WM, Padera RF, Sharma NS, Sholl LM, Vivero M, Watts GFM, Knipe RS, Black KE, Hariri LP, Yun JH, Merriam LT, Yuan K, Kim EY, Brenner MB. Leukemia inhibitory factor (LIF) receptor amplifies pathogenic activation of fibroblasts in lung fibrosis. Proc Natl Acad Sci U S A. 2024 Dec 10; 121(50):e2401899121. PMID: 39636853; PMCID: PMC11648669.
    Citations:
    Fields: SciScienceTranslation:HumansCells
  3. Tamura T, Cheng C, Villaseñor-Altamirano AB, Yamada K, Ikeda K, Hayashida K, Menon JA, Chen XD, Chung H, Varon J, Chen J, Choi J, Cullen AM, Guo J, Lin X, Olenchock BA, Pinilla-Vera MA, Manandhar R, Sheikh MDA, Hou PC, Lawler PR, Oldham WM, Seethala RR, Immunology of Cardiac Arrest Network (I-CAN), Baron RM, Bohula EA, Morrow DA, Blumberg RS, Chen F, Merriam LT, Weissman AJ, Brenner MB, Chen X, Ichinose F, Kim EY. Diverse NKT cells regulate early inflammation and neurological outcomes after cardiac arrest and resuscitation. Sci Transl Med. 2024 Dec 04; 16(776):eadq5796. PMID: 39630883.
    Citations:
    Fields: MedMedicine (General)SciScienceTranslation:HumansAnimalsCells
  4. Torrino S, Oldham WM, Tejedor AR, Burgos IS, Nasr L, Rachedi N, Fraissard K, Chauvet C, Sbai C, O'Hara BP, Abélanet S, Brau F, Favard C, Clavel S, Collepardo-Guevara R, Espinosa JR, Ben-Sahra I, Bertero T. Mechano-dependent sorbitol accumulation supports biomolecular condensate. Cell. 2025 Jan 23; 188(2):447-464.e20. PMID: 39591966; PMCID: PMC11761381.
    Citations:
    Fields: CelCell Biology
  5. Xiao W, Shrimali N, Vigder N, Oldham WM, Clish CB, He H, Wong SJ, Wertheim BM, Arons E, Haigis MC, Leopold JA, Loscalzo J. Author Correction: Branched-chain a-ketoacids aerobically activate HIF1a signalling in vascular cells. Nat Metab. 2024 Nov; 6(11):2203. PMID: 39501107.
    Citations:
    Fields: MetMetabolism
  6. Xiao W, Shrimali N, Vigder N, Oldham WM, Clish CB, He H, Wong SJ, Wertheim BM, Arons E, Haigis MC, Leopold JA, Loscalzo J. Branched-chain a-ketoacids aerobically activate HIF1a signalling in vascular cells. Nat Metab. 2024 Nov; 6(11):2138-2156. PMID: 39472756; PMCID: PMC11786732.
    Citations: 1
    Fields: MetMetabolismTranslation:HumansAnimalsCells
  7. McGarrity S, Ziehr DR, Austin-Tse CA, Wein MN, Chivukula RR, Oldham WM. Exercise Intolerance and Low Cardiac Filling Pressures in a Woman With a Novel eNOS Mutation. Circ Genom Precis Med. 2024 Oct; 17(5):e004741. PMID: 39328057.
    Citations:
    Fields: CarCardiologyGenGenetics, MedicalVasVascular DiseasesTranslation:Humans
  8. Chakraborty A, Bandyopadhaya A, Singh VK, Kovacic F, Cha S, Oldham WM, Tzika AA, Rahme LG. The bacterial quorum sensing signal 2'-aminoacetophenone rewires immune cell bioenergetics through the Ppargc1a/Esrra axis to mediate tolerance to infection. Elife. 2024 Sep 13; 13. PMID: 39269443; PMCID: PMC11398867.
    Citations:
    Fields: BioBiologyTranslation:HumansAnimalsCells
  9. Oldham WM. Exploring the Molecular Signatures of Pulmonary Vascular Lesions. Am J Respir Crit Care Med. 2024 08 01; 210(3):256-257. PMID: 38780073; PMCID: PMC11348971.
    Citations:
    Fields: CriCritical CarePulPulmonary MedicineTranslation:Humans
  10. Kamiya M, Carter H, Espindola MS, Doyle TJ, Lee JS, Merriam LT, Zhang F, Kawano-Dourado L, Sparks JA, Hogaboam CM, Moore BB, Oldham WM, Kim EY. Immune mechanisms in fibrotic interstitial lung disease. Cell. 2024 Jul 11; 187(14):3506-3530. PMID: 38996486; PMCID: PMC11246539.
    Citations: 5
    Fields: CelCell BiologyTranslation:HumansAnimals
  11. Chakraborty A, Bandyopadhaya A, Singh V, Kovacic F, Cha S, Oldham W, Tzika AA, Rahme L. The Bacterial Quorum-Sensing Signal 2-Aminoacetophenone Rewires Immune Cell Bioenergetics through the PGC-1a/ERRa Axis to Mediate Tolerance to Infection. bioRxiv. 2024 Jun 13. PMID: 38464050; PMCID: PMC10925214.
    Citations:
  12. Xiao W, Shrimali N, Oldham WM, Clish CB, He H, Wong SJ, Wertheim BM, Arons E, Haigis MC, Leopold JA, Loscalzo J. Branched chain a-ketoacids aerobically activate HIF1a signaling in vascular cells. bioRxiv. 2024 May 30. PMID: 38853866; PMCID: PMC11160772.
    Citations:
  13. Rachedi NS, Tang Y, Tai YY, Zhao J, Chauvet C, Grynblat J, Akoumia KKF, Estephan L, Torrino S, Sbai C, Ait-Mouffok A, Latoche JD, Al Aaraj Y, Brau F, Abélanet S, Clavel S, Zhang Y, Guillermier C, Kumar NVG, Tavakoli S, Mercier O, Risbano MG, Yao ZK, Yang G, Ouerfelli O, Lewis JS, Montani D, Humbert M, Steinhauser ML, Anderson CJ, Oldham WM, Perros F, Bertero T, Chan SY. Dietary intake and glutamine-serine metabolism control pathologic vascular stiffness. Cell Metab. 2024 Jun 04; 36(6):1335-1350.e8. PMID: 38701775; PMCID: PMC11152997.
    Citations: 4
    Fields: CelCell BiologyMetMetabolismTranslation:HumansAnimalsCells
  14. Ziehr DR, Li F, Parnell KM, Krah NM, Leahy KJ, Guillermier C, Varon J, Baron RM, Maron BA, Philp NJ, Hariri LP, Kim EY, Steinhauser ML, Knipe RS, Rutter J, Oldham WM. Lactate transport inhibition therapeutically reprograms fibroblast metabolism in experimental pulmonary fibrosis. bioRxiv. 2024 Apr 28. PMID: 38712233; PMCID: PMC11071479.
    Citations:
  15. Maron BA, Wang RS, Shevtsov S, Drakos SG, Arons E, Wever-Pinzon O, Huggins GS, Samokhin AO, Oldham WM, Aguib Y, Yacoub MH, Rowin EJ, Maron BJ, Maron MS, Loscalzo J. Author Correction: Individualized interactomes for network-based precision medicine in hypertrophic cardiomyopathy with implications for other clinical pathophenotypes. Nat Commun. 2024 Apr 08; 15(1):3038. PMID: 38589351; PMCID: PMC11002015.
    Citations:
    Fields: BioBiologySciScience
  16. Philip N, Yun X, Pi H, Murray S, Hill Z, Fonticella J, Perez P, Zhang C, Pathmasiri W, Sumner S, Servinsky L, Jiang H, Huetsch JC, Oldham WM, Visovatti S, Leary PJ, Gharib SA, Brittain E, Simpson CE, Le A, Shimoda LA, Suresh K. Fatty acid metabolism promotes TRPV4 activity in lung microvascular endothelial cells in pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol. 2024 Mar 01; 326(3):L252-L265. PMID: 38226418; PMCID: PMC11280685.
    Citations: 1
    Fields: CelCell BiologyMolMolecular BiologyPhyPhysiologyPulPulmonary Medicine
  17. Li G, Huang H, Wu Y, Shu C, Hwang N, Li Q, Zhao R, Lam HC, Oldham WM, Ei-Chemaly S, Agrawal PB, Tian J, Liu X, Perrella MA. Striated preferentially expressed gene deficiency leads to mitochondrial dysfunction in developing cardiomyocytes. Basic Res Cardiol. 2024 02; 119(1):151-168. PMID: 38145999; PMCID: PMC10837246.
    Citations:
    Fields: CarCardiologyTranslation:AnimalsCells
  18. Wang RS, Huang S, Waldo SW, Hess E, Gokhale M, Johnson SW, Zeder K, Choudhary G, Leopold JA, Oldham WM, Kovacs G, Freiberg MS, Tedford RJ, Maron BA, Brittain EL. Elevated Pulmonary Arterial Compliance Is Associated with Survival in Pulmonary Hypertension: Results from a Novel Network Medicine Analysis. Am J Respir Crit Care Med. 2023 08 01; 208(3):312-321. PMID: 37276608; PMCID: PMC10395727.
    Citations: 9
    Fields: CriCritical CarePulPulmonary MedicineTranslation:Humans
  19. Torrino S, Oldham WM, Tejedor AR, Burgos IS, Rachedi N, Fraissard K, Chauvet C, Sbai C, O'Hara BP, Abélanet S, Brau F, Clavel S, Collepardo-Guevara R, Espinosa JR, Ben-Sahra I, Bertero T. Mechano-dependent sorbitol accumulation supports biomolecular condensate. bioRxiv. 2023 Jul 25. PMID: 37546967; PMCID: PMC10402034.
    Citations:
  20. Copeland CA, Olenchock BA, Ziehr D, McGarrity S, Leahy K, Young JD, Loscalzo J, Oldham WM. MYC overrides HIF-1a to regulate proliferating primary cell metabolism in hypoxia. Elife. 2023 07 10; 12. PMID: 37428010; PMCID: PMC10332812.
    Citations: 2
    Fields: BioBiologyTranslation:HumansCells
  21. Tamura T, Cheng C, Chen W, Merriam LT, Athar H, Kim YH, Manandhar R, Amir Sheikh MD, Pinilla-Vera M, Varon J, Hou PC, Lawler PR, Oldham WM, Seethala RR, Tesfaigzi Y, Immunology of Cardiac Arrest Network (I-CAN), Weissman AJ, Baron RM, Ichinose F, Berg KM, Bohula EA, Morrow DA, Chen X, Kim EY. Single-cell transcriptomics reveal a hyperacute cytokine and immune checkpoint axis after cardiac arrest in patients with poor neurological outcome. Med. 2023 Jul 14; 4(7):432-456.e6. PMID: 37257452; PMCID: PMC10524451.
    Citations:
    Fields: MedMedicine (General)Translation:HumansCells
  22. Diaz-Cuadros M, Miettinen TP, Skinner OS, Sheedy D, Díaz-García CM, Gapon S, Hubaud A, Yellen G, Manalis SR, Oldham WM, Pourquié O. Author Correction: Metabolic regulation of species-specific developmental rates. Nature. 2023 Apr; 616(7956):E4. PMID: 36949206.
    Citations:
    Fields: SciScience
  23. Wertheim BM, Wang RS, Guillermier C, Hütter CV, Oldham WM, Menche J, Steinhauser ML, Maron BA. Proline and glucose metabolic reprogramming supports vascular endothelial and medial biomass in pulmonary arterial hypertension. JCI Insight. 2023 02 22; 8(4). PMID: 36626231; PMCID: PMC9977503.
    Citations: 12
    Fields: MedMedicine (General)Translation:HumansCells
  24. Diaz-Cuadros M, Miettinen TP, Skinner OS, Sheedy D, Díaz-García CM, Gapon S, Hubaud A, Yellen G, Manalis SR, Oldham WM, Pourquié O. Metabolic regulation of species-specific developmental rates. Nature. 2023 01; 613(7944):550-557. PMID: 36599986; PMCID: PMC9944513.
    Citations: 37
    Fields: SciScienceTranslation:HumansAnimalsCells
  25. Maron BA, Wang RS, Shevtsov S, Drakos SG, Arons E, Wever-Pinzon O, Huggins GS, Samokhin AO, Oldham WM, Aguib Y, Yacoub MH, Rowin EJ, Maron BJ, Maron MS, Loscalzo J. Author Correction: Individualized interactomes for network-based precision medicine in hypertrophic cardiomyopathy with implications for other clinical pathophenotypes. Nat Commun. 2022 Nov 17; 13(1):7026. PMID: 36396654; PMCID: PMC9672304.
    Citations:
    Fields: BioBiologySciScience
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.