Harvard Catalyst Profiles

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Bruce S. Kristal, Ph.D.

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Biography
M.I.T., Cambridge, MABS06/1986Life Sciences
Harvard University, Graduate School of Arts and Sciences, Division of Medical Sciences, Cambridge, MAPhD06/1991Virology
University of Texas Health Science Center San Antonio, San Antonio, TXpost-doc12/1994Aging, caloric restriction, mitochondria, reactive species

Overview
Faculty Academic Appointments

12/92-11/93 Instructor Department of Physiology UTHSCSA
12/93-12/96 Assistant Professor Department of Physiology UTHSCSA
06/97-05/04 Assistant Professor Department of Biochemistry Weill Medical College of Cornell University, New York, NY
10/98-06/06 Assistant Professor Department of Neuroscience Weill Medical College of Cornell University
07/04-04/07 Associate Professor Department of Neuroscience Weill Medical College of Cornell University
01/08 - 9/16 Associate Professor Department of Surgery Harvard Medical School;
Split to newly created Department of Neurosurgery (11/2013)
10/16 -- present Associate Professor Department of Medicine Harvard Medical School



Appointments at Hospitals/Affiliated Institutions

12/96-04/07 Research Scientist Dementia Research Service Burke Medical Research Institute
04/07-12/06 Lead Investigator Department of Neurosurgery Brigham and Women’s Hospital
01/16 - Lead Investigator-Biochemist Division of Sleep and Circadian Disorders Brigham and Women’s Hospital



Professional Societies

American Association for Advancement of Science (AAAS)
American Cancer Society
American Chemical Society (ACS)
American Society for Biochemistry and Molecular Biology (ASBMB)
American Society for Nutrition
Sleep Research Society



Issued US patents

Biomarkers for health effects of low calorie diets Kristal, B.S., W.R. Matson, P.E. Milbury, Methodology for predicting and/or diagnosing disease, US Patent 6,558,955, issued 5/6/2003
Identification of biomarkers of caloric restriction as potential markers for human disease risk using a Coularray-based (electrochemistry) approach

Metabolomics Patent Family, 10 Issued US Patents, Kaddurah-Daouk, R., and Kristal, B.S., Methods for drug discovery, disease treatment, and diagnosis using metabolomics. This patent family was originally licensed from our lab by Metabolon from Weill Medical College of Cornell University.

Kaddurah-Daouk, R., and Kristal, B.S., Methods for drug discovery, disease treatment, and diagnosis using metabolomics, US Patent 7,005,255, issued 2/28/2006
Describes a method for identifying small molecules relevant for ALS, i.e., this is the primary patent for the use of metabolomics for studies related to ALS.

Kaddurah-Daouk, R., and Kristal, B.S., Methods for drug discovery, disease treatment, and diagnosis using metabolomics, US Patent 7,329,489, issued 2/12/2008
Describes a method for identifying small molecules relevant for ALS, schizophrenia, depression, Huntington’s disease, Alzheimer’s disease, and Parkinson’s disease, i.e., this is the primary patent for the use of metabolomics for the major neurological diseases

Kaddurah-Daouk, R., and Kristal, B.S., Methods for drug discovery, disease treatment, and diagnosis using metabolomics, US Patent 7,550,258, issued 6/23/2009
This is the primary patent for the use of metabolomics for most neurological diseases and conditions not specifically covered above.

Kaddurah-Daouk, R., and Kristal, B.S., Methods for drug discovery, disease treatment, and diagnosis using metabolomics, US Patent 7,550,260, issued 6/23/2009
This is the primary patent for the use of metabolomics for most metabolic diseases including diabetes, obesity, cachexia, and anorexia.

Kaddurah-Daouk, R., and Kristal, B.S., Methods for drug discovery, disease treatment, and diagnosis using metabolomics, US Patent 7,553,616, issued 6/30/2009
This is the primary patent for the use of metabolomics for most oncologic diseases (cancer)

Kaddurah-Daouk, R., and Kristal, B.S., Methods for drug discovery, disease treatment, and diagnosis using metabolomics, US Patent 7,635,556, issued 12/22/2009
This is the primary patent for the use of metabolomics to address the effects of added agents (e.g., drugs, therapeutics) in patients suffering metabolic, immunologic, neurologic, oncologic, diseases, viral infections, and other diseases, i.e., this is the primary patent for the use of metabolomics for issues related to drug development or drug treatments

Kaddurah-Daouk, R., and Kristal, B.S., Methods for drug discovery, disease treatment, and diagnosis using metabolomics, US Patent 7,682,783, issued 3/23/2010
This patent furthers the description of the use of metabolomics in depression
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Kaddurah-Daouk, R., and Kristal, B.S., Methods for drug discovery, disease treatment, and diagnosis using metabolomics, US Patent 7,682,784, issued 3/23/2010
This patent furthers the description of the use of metabolomics in schizophrenia.

Kaddurah-Daouk, R., and Kristal, B.S., Methods for drug discovery, disease treatment, and diagnosis using metabolomics, US Patent 7,910,301, issued 3/22/2011
This patent furthers the description of the use of metabolomics in studying the effects of exogenous agents, including the use of metabolomics for studying/determining toxicity and known and unknown toxins.

Kaddurah-Daouk, R., and Kristal, B.S., Methods for drug discovery, disease treatment, and diagnosis using metabolomics, US Patent 7,947,453, issued 5/24/2011
This patent covers the use of metabolomics for the primary prediction of the effect of a drug on an individual.

Machine Learning Patent Family, two issued patents, Kristal, B.S. and Martin R.J., System and method to enable training a machine learning network in the presence of weak or absent training exemplars
This patent family enables the combining of human and machine intelligence for solving problems in which the users lack the typically required large datasets. The two patents differ in technical aspects of how the modeling can be done.

Kristal, B.S. and Martin R.J., System and method to enable training a machine learning network in the presence of weak or absent training exemplars, US Patent 8,095,480, issued 1/10/2012

Kristal, B.S. and Martin R.J., System and method to enable training a machine learning network in the presence of weak or absent training exemplars, US Patent
8,838,511, issued 9/16/2014



Trainees

Junior Faculty
Co-mentor, Katherine Gregory, K23 Award, (note: Boston College Faculty at the time of K-award, now Harvard Medical school Faculty)

Post-Doctoral Fellows
Honglian Shi, PhD,
Boris F. Krasnikov, PhD,
Ugo Paolucci, MD,
Irina Stavrovskaya, PhD (also mentored as HMS Instructor)
Sergei Baranov, PhD
Xiaofeng (Sophie) Guo, PhD
Susan Bird (née Schaivo), PhD (also mentored as HMS Instructor)
Rose Gathungu, PhD (also mentored as HMS Instructor)
Fateme Tousi, PhD
Shucha Zhang, PhD
Marlen Menlyadiev, PhD (Current)

Harvard College Undergraduates
Defne Altan, research and advisor for her honors undergraduate thesis (Thomas T Hoopes Prize)



Research Interests
My lab’s primary projects relate to the use of metabolomics and lipidomics for personalized risk analysis for future chronic/age-related diseases based on diet (quantity and quality), adiposity and other “lifestyle” factors such as sleep and circadian phenotypes. We seek to work across disciplines, resolving issues at the levels of analytical chemistry and informatics as well as in the biological and clinical realms. I served as the founding secretary and member of the Board of Directors of the Metabolomics Society (2004-2008) and on their Board of Directors (2004-2011).

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HL140335 (KRISTAL, BRUCE S) Sep 1, 2018 - Jun 30, 2022
    NIH
    Lipidomics Biomarkers Link Sleep Restriction to Adiposity Phenotype, Diabetes, and Cardiovascular Risk
    Role: Principal Investigator
  2. R01HL132556 (KRISTAL, BRUCE S) Apr 18, 2016 - Mar 31, 2021
    NIH
    Circadian Lipidomics in Constant Routine, Forced Desynchrony, and Non-lab Setting
    Role: Principal Investigator
  3. R01AG045713 (KRISTAL, BRUCE S) Aug 15, 2013 - May 31, 2015
    NIH
    High Resolution Plasma Lipidomics in CALERIE
    Role: Principal Investigator
  4. P01CA168530 (LE MARCHAND, LOIC) Sep 1, 2012 - Aug 31, 2017
    NIH/NCI
    Obesity, Body Fat Distribution, and Cancer Risk in the Multiethnic Cohort
    Role: Co-Principal Investigator
  5. R01HL109239 (KRISTAL, BRUCE S) Apr 2, 2012 - Mar 31, 2016
    NIH
    BiospecimenIntegrity: Assessing Quality and Influence on -Omics-based Analyses
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.