Harvard Catalyst Profiles

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Kwonmoo Lee, Ph.D.

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Biography
education and training
Harvard Medical School, Boston, MAPost-doc06/2014Cell Biology
Massachusetts Institute of Technology, Cambridge, MAPh.D.06/2010Physics (Biophysics)
Pohang University of Science and Technology, Pohang, South KoreaM.S.02/1998Physics
Pohang University of Science and Technology, Pohang, South KoreaB.S.02/1996Electrical Engineering

Overview

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R35GM133725 (Lee, Kwonmoo) Sep 15, 2024 - Aug 31, 2029
    NIH/NIGMS
    Unraveling Heterogeneity of Molecular Mechanisms in Cellular Motility and Morphodynamics by Machine Learning
    Role: Principal Investigator
  2. R01CA279948 (Ahn, Eun Hyun) Jun 13, 2024 - May 31, 2029
    NIH/NCI
    Engineered biomimetic collective cancer invasion models for screening chemotherapeutic agents
    Role: Co-Investigator
  3. R01HL163513 (LEE, KWONMOO & LEE, HAKHO) Apr 1, 2023 - Feb 28, 2027
    NIH/NHLBI
    High-throughput Phenotyping of iPSC-derived Airway Epithelium by Multiscale Machine Learning Microscopy
    Role: Principal Investigator
  4. 3R35GM133725-05S1 (LEE, KWONMOO) Sep 15, 2022 - Aug 31, 2023
    NIH
    Purchase of a light microscopy system for high-throughput and high-resolution live cell imaging
    Role: Principal Investigator
  5. R01HL163168 (BAE, YONGHO) Sep 1, 2022 - Aug 31, 2027
    NIH
    Biomimetic Vascular Matrix for Vascular Smooth Muscle Cell Mechanobiology and Pathology
    Role: Co-Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Busatto S, Song TH, Kim HJ, Hallinan C, Lombardo MN, Stemmer-Rachamimov AO, Lee K, Moses MA. Breast Cancer-Derived Extracellular Vesicles Modulate the Cytoplasmic and Cytoskeletal Dynamics of Blood-Brain Barrier Endothelial Cells. J Extracell Vesicles. 2025 Jan; 14(1):e70038. PMID: 39868462; PMCID: PMC11770372.
    Citations:
    Fields: BioBiomedical EngineeringCelCell Biology
  2. Mousso T, Rice K, Tumenbayar BI, Pham K, Heo Y, Heo SC, Lee K, Lombardo AT, Bae Y. Survivin modulates stiffness-induced vascular smooth muscle cell motility. bioRxiv. 2024 Dec 12. PMID: 39713437; PMCID: PMC11661181.
    Citations:
  3. Wang C, Choi HJ, Woodbury L, Lee K. Interpretable Fine-Grained Phenotypes of Subcellular Dynamics via Unsupervised Deep Learning. Adv Sci (Weinh). 2024 Nov; 11(41):e2403547. PMID: 39239705; PMCID: PMC11538677.
    Citations: 1
    Fields: BioBiomedical EngineeringTranslation:Humans
  4. Moon D, Kim S, Wang C, Lee K, Doh J. Deep learning-based automated analysis of NK cell cytotoxicity in single cancer cell arrays. BioChip Journal. 2024.View Publication.
  5. Song TH, Clemente L, Pan X, Jang J, Santillana M, Lee K. Fine-Grained Forecasting of COVID-19 Trends at the County Level in the United States. medRxiv. 2024 Mar 25. PMID: 38293076; PMCID: PMC10827234.
    Citations:
  6. Basher ARMA, Hallinan C, Lee K. Heterogeneity-Preserving Discriminative Feature Selection for Subtype Discovery. bioRxiv. 2023 Dec 20. PMID: 38187596; PMCID: PMC10769187.
    Citations:
  7. Biber JC, Sullivan A, Brazzo JA, Heo Y, Tumenbayar BI, Krajnik A, Poppenberg KE, Tutino VM, Heo SJ, Kolega J, Lee K, Bae Y. Survivin as a mediator of stiffness-induced cell cycle progression and proliferation of vascular smooth muscle cells. APL Bioeng. 2023 Dec; 7(4):046108. PMID: 37915752; PMCID: PMC10618027.
    Citations: 2
  8. Krajnik A, Nimmer E, Brazzo JA, Biber JC, Drewes R, Tumenbayar BI, Sullivan A, Pham K, Krug A, Heo Y, Kolega J, Heo SJ, Lee K, Weil BR, Kim DH, Gupte SA, Bae Y. Survivin regulates intracellular stiffness and extracellular matrix production in vascular smooth muscle cells. APL Bioeng. 2023 Dec; 7(4):046104. PMID: 37868708; PMCID: PMC10590228.
    Citations: 3
  9. Jang J, Lee K, Kim TK. Unsupervised Contour Tracking of Live Cells by Mechanical and Cycle Consistency Losses. Proc IEEE Comput Soc Conf Comput Vis Pattern Recognit. 2023 Jun; 2023:227-236. PMID: 38250674; PMCID: PMC10798679.
    Citations: 1
  10. Jang J, Kim YH, Westgate B, Zong Y, Hallinan C, Akalin A, Lee K. Screening adequacy of unstained thyroid fine needle aspiration samples using a deep learning-based classifier. Sci Rep. 2023 08 19; 13(1):13525. PMID: 37598279; PMCID: PMC10439921.
    Citations:
    Fields: SciScienceTranslation:Humans
  11. Pan X, Wang C, Yu Y, Reljin N, McManus DD, Darling CE, Chon KH, Mendelson Y, Lee K. Deep cross-modal feature learning applied to predict acutely decompensated heart failure using in-home collected electrocardiography and transthoracic bioimpedance. Artif Intell Med. 2023 06; 140:102548. PMID: 37210152; PMCID: PMC10201018.
    Citations: 2
    Fields: MedMedical InformaticsTranslation:Humans
  12. Jang J, Hallinan C, Lee K. Protocol for live cell image segmentation to profile cellular morphodynamics using MARS-Net. STAR Protoc. 2022 09 16; 3(3):101469. PMID: 35733606; PMCID: PMC9207580.
    Citations: 2
    Fields: BioBiologySciScience
  13. Vaidyanathan K, Wang C, Krajnik A, Yu Y, Choi M, Lin B, Jang J, Heo SJ, Kolega J, Lee K, Bae Y. A machine learning pipeline revealing heterogeneous responses to drug perturbations on vascular smooth muscle cell spheroid morphology and formation. Sci Rep. 2021 12 02; 11(1):23285. PMID: 34857846; PMCID: PMC8640073.
    Citations: 5
    Fields: SciScienceTranslation:HumansCells
  14. Omebeyinje MH, Adeluyi A, Mitra C, Chakraborty P, Gandee GM, Patel N, Verghese B, Farrance CE, Hull M, Basu P, Lee K, Adhikari A, Adivar B, Horney JA, Chanda A. Increased prevalence of indoor Aspergillus and Penicillium species is associated with indoor flooding and coastal proximity: a case study of 28 moldy buildings. Environ Sci Process Impacts. 2021 Nov 17; 23(11):1681-1687. PMID: 34596193.
    Citations: 4
    Fields: EnvEnvironmental HealthTranslation:AnimalsPHPublic Health
  15. Jang J, Wang C, Zhang X, Choi HJ, Pan X, Lin B, Yu Y, Whittle C, Ryan M, Chen Y, Lee K. A deep learning-based segmentation pipeline for profiling cellular morphodynamics using multiple types of live cell microscopy. Cell Rep Methods. 2021 11 22; 1(7). PMID: 34888542; PMCID: PMC8654120.
    Citations: 14
    Fields: CelCell BiologyMolMolecular Biology
  16. Choi HJ, Wang C, Pan X, Jang J, Cao M, Brazzo JA, Bae Y, Lee K. Emerging machine learning approaches to phenotyping cellular motility and morphodynamics. Phys Biol. 2021 06 17; 18(4). PMID: 33971636; PMCID: PMC9131244.
    Citations: 9
    Fields: BioBiologyBioBiophysics
  17. Brazzo JA, Biber JC, Nimmer E, Heo Y, Ying L, Zhao R, Lee K, Krause M, Bae Y. Mechanosensitive expression of lamellipodin promotes intracellular stiffness, cyclin expression and cell proliferation. J Cell Sci. 2021 06 15; 134(12). PMID: 34152388.
    Citations: 6
    Fields: CelCell BiologyTranslation:AnimalsCells
  18. Iii JAB, Biber JC, Nimmer E, Heo Y, Ying L, Zhao R, Lee K, Krause M, Bae Y. Mechanosensitive expression of lamellipodin promotes intracellular stiffness, cyclin expression, and cell proliferation. J Cell Sci. 2021 May 25. PMID: 34031693.
    Citations:
    Fields: CelCell Biology
  19. Kim SJ, Wang C, Zhao B, Im H, Min J, Choi HJ, Tadros J, Choi NR, Castro CM, Weissleder R, Lee H, Lee K. Deep transfer learning-based hologram classification for molecular diagnostics. Sci Rep. 2018 11 19; 8(1):17003. PMID: 30451953; PMCID: PMC6242900.
    Citations: 19
    Fields: SciScienceTranslation:HumansCells
  20. Wang C, Choi HJ, Kim SJ, Desai A, Lee N, Kim D, Bae Y, Lee K. Deconvolution of subcellular protrusion heterogeneity and the underlying actin regulator dynamics from live cell imaging. Nat Commun. 2018 04 27; 9(1):1688. PMID: 29703977; PMCID: PMC5923236.
    Citations: 13
    Fields: BioBiologySciScienceTranslation:HumansAnimalsCells
  21. Lee K, Elliott HL, Oak Y, Zee CT, Groisman A, Tytell JD, Danuser G. Functional hierarchy of redundant actin assembly factors revealed by fine-grained registration of intrinsic image fluctuations. Cell Syst. 2015 Jul 29; 1(1):37-50. PMID: 26273703.
    Citations: 37
    Fields: CelCell BiologyComComputational BiologyMolMolecular Biology
  22. Lee K, Gallop JL, Rambani K, Kirschner MW. Self-assembly of filopodia-like structures on supported lipid bilayers. Science. 2010 Sep 10; 329(5997):1341-5. PMID: 20829485.
    Citations: 74
    Fields: SciScienceTranslation:HumansAnimalsCells
  23. Lee K, Sung W. A Stochastic Model of Conductance Transitions in Voltage-Gated IonChannels. J Biol Phys. 2002 Jun; 28(2):279-88. PMID: 23345775; PMCID: PMC3456657.
    Citations: 1
    Fields: BioBiophysicsPhyPhysics
  24. Lee K, Sung W. Effects of nonequilibrium fluctuations on ionic transport through biomembranes. Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics. 1999 Oct; 60(4 Pt B):4681-6. PMID: 11970332.
    Citations: 2
    Fields: MedMedicine (General)PhyPhysics
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.