SB15SusanBonner-WeirSusan Bonner-Weir, Ph.D.42.33839600000000-71.1084030000000050522Bonner-Weir, Susan617/732-2581Professor of Medicinecatalyst:advisorInMentoringCompletedStudentProjectcompleted student projectscatalyst:eCommonsLogineCommons LoginMentoring - Completed Student Projectprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:address2address line 2vivo:address3address line 3vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:overviewoverviewvivo:personInPositionpositionsvivo:phoneNumberphonePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofvivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson10078550Sharma A, Zangen DH, Reitz P, Taneja M, Lissauer ME, Miller CP, Weir GC, Habener JF, Bonner-Weir SDiabetesThe homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration. Diabetes. 1999 Mar; 48(3):507-13.Diabetes1999-03-01T00:00:001999The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration.11699059Orban T, Landaker E, Ruan Z, Cordeman TP, Weitgasser R, Bonner-Weir S, Jackson RA, Patti MEMetabolism: clinical and experimentalHigh-fructose diet preserves beta-cell mass and prevents diabetes in nonobese diabetic mice: A potential role for increased insulin receptor substrate-2 expression. Metabolism. 2001 Nov; 50(11):1369-76.Metabolism2001-11-01T00:00:002001High-fructose diet preserves beta-cell mass and prevents diabetes in nonobese diabetic mice: A potential role for increased insulin receptor substrate-2 expression.Authorship 10479831129478894Rezanejad H, Ouziel-Yahalom L, Keyzer CA, Sullivan BA, Hollister-Lock J, Li WC, Guo L, Deng S, Lei J, Markmann J, Bonner-Weir SStem cell reportsHeterogeneity of SOX9 and HNF1ß in Pancreatic Ducts Is Dynamic. Stem Cell Reports. 2018 03 13; 10(3):725-738.Stem Cell Reports2018-03-01T00:00:002018Heterogeneity of SOX9 and HNF1ß in Pancreatic Ducts Is Dynamic.10401769Feng S, Quickel RR, Hollister-Lock J, McLeod M, Bonner-Weir S, Mulligan RC, Weir GCTransplantationProlonged xenograft survival of islets infected with small doses of adenovirus expressing CTLA4Ig. Transplantation. 1999 Jun 27; 67(12):1607-13.Transplantation1999-06-27T00:00:001999Prolonged xenograft survival of islets infected with small doses of adenovirus expressing CTLA4Ig.12694544Omer A, Keegan M, Czismadia E, De Vos P, Van Rooijen N, Bonner-Weir S, Weir GCXenotransplantationMacrophage depletion improves survival of porcine neonatal pancreatic cell clusters contained in alginate macrocapsules transplanted into rats. Xenotransplantation. 2003 May; 10(3):240-51.Xenotransplantation2003-05-01T00:00:002003Macrophage depletion improves survival of porcine neonatal pancreatic cell clusters contained in alginate macrocapsules transplanted into rats.Authorship 10507371229539434Loomans CJM, Williams Giuliani N, Balak J, Ringnalda F, van Gurp L, Huch M, Boj SF, Sato T, Kester L, de Sousa Lopes SMC, Roost MS, Bonner-Weir S, Engelse MA, Rabelink TJ, Heimberg H, Vries RGJ, van Oudenaarden A, Carlotti F, Clevers H, de Koning EJPStem cell reportsExpansion of Adult Human Pancreatic Tissue Yields Organoids Harboring Progenitor Cells with Endocrine Differentiation Potential. Stem Cell Reports. 2018 03 13; 10(3):712-724.Stem Cell Reports2018-03-13T00:00:002018Expansion of Adult Human Pancreatic Tissue Yields Organoids Harboring Progenitor Cells with Endocrine Differentiation Potential.7042327Roth J, Bonner-Weir S, Norman AW, Orci LEndocrinologyImmunocytochemistry of vitamin D-dependent calcium binding protein in chick pancreas: exclusive localization. Endocrinology. 1982 Jun; 110(6):2216-8.Endocrinology1982-06-01T00:00:001982Immunocytochemistry of vitamin D-dependent calcium binding protein in chick pancreas: exclusive localization.15024072Inada A, Hamamoto Y, Tsuura Y, Miyazaki J, Toyokuni S, Ihara Y, Nagai K, Yamada Y, Bonner-Weir S, Seino YMolecular and cellular biologyOverexpression of inducible cyclic AMP early repressor inhibits transactivation of genes and cell proliferation in pancreatic beta cells. Mol Cell Biol. 2004 Apr; 24(7):2831-41.Mol Cell Biol2004-04-01T00:00:002004Overexpression of inducible cyclic AMP early repressor inhibits transactivation of genes and cell proliferation in pancreatic beta cells.15321004Bonner-Weir S, Grodsky GDiabetes technology & therapeuticsAssessment of human islet preparations to be used for islet expansion, survival, or transplant. Diabetes Technol Ther. 2004 Aug; 6(4):493-4.Diabetes Technol Ther2004-08-01T00:00:002004Assessment of human islet preparations to be used for islet expansion, survival, or transplant.15601370Bonner-Weir S, Toschi E, Inada A, Reitz P, Fonseca SY, Aye T, Sharma APediatric diabetesThe pancreatic ductal epithelium serves as a potential pool of progenitor cells. Pediatr Diabetes. 2004; 5 Suppl 2:16-22.Pediatr Diabetes2004-01-01T00:00:002004The pancreatic ductal epithelium serves as a potential pool of progenitor cells.8539921Juang JH, Bonner-Weir S, Vacanti JP, Weir GCTransplantation proceedingsOutcome of subcutaneous islet transplantation improved by a polymer device. Transplant Proc. 1995 Dec; 27(6):3215-6.Transplant Proc1995-12-01T00:00:001995Outcome of subcutaneous islet transplantation improved by a polymer device.9495343Withers DJ, Gutierrez JS, Towery H, Burks DJ, Ren JM, Previs S, Zhang Y, Bernal D, Pons S, Shulman GI, Bonner-Weir S, White MFNatureDisruption of IRS-2 causes type 2 diabetes in mice. Nature. 1998 Feb 26; 391(6670):900-4.Nature1998-02-26T00:00:001998Disruption of IRS-2 causes type 2 diabetes in mice.10318828Jonas JC, Sharma A, Hasenkamp W, Ilkova H, Patanè G, Laybutt R, Bonner-Weir S, Weir GCThe Journal of biological chemistryChronic hyperglycemia triggers loss of pancreatic beta cell differentiation in an animal model of diabetes. J Biol Chem. 1999 May 14; 274(20):14112-21.J Biol Chem1999-05-14T00:00:001999Chronic hyperglycemia triggers loss of pancreatic beta cell differentiation in an animal model of diabetes.10884429Bonner-Weir S, Taneja M, Weir GC, Tatarkiewicz K, Song KH, Sharma A, O'Neil JJProceedings of the National Academy of Sciences of the United States of AmericaIn vitro cultivation of human islets from expanded ductal tissue. Proc Natl Acad Sci U S A. 2000 Jul 05; 97(14):7999-8004.Proc Natl Acad Sci U S A2000-07-05T00:00:002000In vitro cultivation of human islets from expanded ductal tissue.2119440Helton WS, Jacobs DO, Bonner-Weir S, Bueno R, Smith RJ, Wilmore DWJPEN. Journal of parenteral and enteral nutritionEffects of glutamine-enriched parenteral nutrition on the exocrine pancreas. JPEN J Parenter Enteral Nutr. 1990 Jul-Aug; 14(4):344-52.JPEN J Parenter Enteral Nutr1990-07-01T00:00:001990Effects of glutamine-enriched parenteral nutrition on the exocrine pancreas.17641871Laybutt DR, Hawkins YC, Lock J, Lebet J, Sharma A, Bonner-Weir S, Weir GCDiabetologiaInfluence of diabetes on the loss of beta cell differentiation after islet transplantation in rats. Diabetologia. 2007 Oct; 50(10):2117-25.Diabetologia2007-07-20T00:00:002007Influence of diabetes on the loss of beta cell differentiation after islet transplantation in rats.17670937Koulmanda M, Budo E, Bonner-Weir S, Qipo A, Putheti P, Degauque N, Shi H, Fan Z, Flier JS, Auchincloss H, Zheng XX, Strom TBProceedings of the National Academy of Sciences of the United States of AmericaModification of adverse inflammation is required to cure new-onset type 1 diabetic hosts. Proc Natl Acad Sci U S A. 2007 Aug 07; 104(32):13074-9.Proc Natl Acad Sci U S A2007-08-01T00:00:002007Modification of adverse inflammation is required to cure new-onset type 1 diabetic hosts.11430820Scheuner D, Song B, McEwen E, Liu C, Laybutt R, Gillespie P, Saunders T, Bonner-Weir S, Kaufman RJMolecular cellTranslational control is required for the unfolded protein response and in vivo glucose homeostasis. Mol Cell. 2001 Jun; 7(6):1165-76.Mol Cell2001-06-01T00:00:002001Translational control is required for the unfolded protein response and in vivo glucose homeostasis.11714718Kaneto H, Suzuma K, Sharma A, Bonner-Weir S, King GL, Weir GCThe Journal of biological chemistryInvolvement of protein kinase C beta 2 in c-myc induction by high glucose in pancreatic beta-cells. J Biol Chem. 2002 Feb 01; 277(5):3680-5.J Biol Chem2001-11-19T00:00:002001Involvement of protein kinase C beta 2 in c-myc induction by high glucose in pancreatic beta-cells.19504246Marselli L, Sgroi DC, Bonner-Weir S, Weir GCMethods in molecular biology (Clifton, N.J.)Laser capture microdissection of human pancreatic beta-cells and RNA preparation for gene expression profiling. Methods Mol Biol. 2009; 560:87-98.Methods Mol Biol2009-01-01T00:00:002009Laser capture microdissection of human pancreatic beta-cells and RNA preparation for gene expression profiling.Authorship 10578401329625991Aguayo-Mazzucato C, Lee TB, Matzko M, DiIenno A, Rezanejad H, Ramadoss P, Scanlan T, Zavacki AM, Larsen PR, Hollenberg A, Colton C, Sharma A, Bonner-Weir SDiabetesT3 Induces Both Markers of Maturation and Aging in Pancreatic ß-Cells. Diabetes. 2018 07; 67(7):1322-1331.Diabetes2018-04-06T00:00:002018T3 Induces Both Markers of Maturation and Aging in Pancreatic ß-Cells.15752744Inada A, Weir GC, Bonner-Weir SBiochemical and biophysical research communicationsInduced ICER Igamma down-regulates cyclin A expression and cell proliferation in insulin-producing beta cells. Biochem Biophys Res Commun. 2005 Apr 15; 329(3):925-9.Biochem Biophys Res Commun2005-04-15T00:00:002005Induced ICER Igamma down-regulates cyclin A expression and cell proliferation in insulin-producing beta cells.19407223Kondo T, El Khattabi I, Nishimura W, Laybutt DR, Geraldes P, Shah S, King G, Bonner-Weir S, Weir G, Sharma AMolecular endocrinology (Baltimore, Md.)p38 MAPK is a major regulator of MafA protein stability under oxidative stress. Mol Endocrinol. 2009 Aug; 23(8):1281-90.Mol Endocrinol2009-04-30T00:00:002009p38 MAPK is a major regulator of MafA protein stability under oxidative stress.20876724Bonner-Weir S, Li WC, Ouziel-Yahalom L, Guo L, Weir GC, Sharma ADiabetesBeta-cell growth and regeneration: replication is only part of the story. Diabetes. 2010 Oct; 59(10):2340-8.Diabetes2010-10-01T00:00:002010Beta-cell growth and regeneration: replication is only part of the story.21240476Jermendy A, Toschi E, Aye T, Koh A, Aguayo-Mazzucato C, Sharma A, Weir GC, Sgroi D, Bonner-Weir SDiabetologiaRat neonatal beta cells lack the specialised metabolic phenotype of mature beta cells. Diabetologia. 2011 Mar; 54(3):594-604.Diabetologia2011-01-16T00:00:002011Rat neonatal beta cells lack the specialised metabolic phenotype of mature beta cells.Authorship 11498993284912Leahy JL, Bonner-Weir S, Weir GCThe Journal of clinical investigationMinimal chronic hyperglycemia is a critical determinant of impaired insulin secretion after an incomplete pancreatectomy. J Clin Invest. 1988 May; 81(5):1407-14.J Clin Invest1988-05-01T00:00:001988Minimal chronic hyperglycemia is a critical determinant of impaired insulin secretion after an incomplete pancreatectomy.8243817Bonner-Weir S, Baxter LA, Schuppin GT, Smith FEDiabetesA second pathway for regeneration of adult exocrine and endocrine pancreas. A possible recapitulation of embryonic development. Diabetes. 1993 Dec; 42(12):1715-20.Diabetes1993-12-01T00:00:001993A second pathway for regeneration of adult exocrine and endocrine pancreas. A possible recapitulation of embryonic development.Authorship 104167519907327Juhl K, Bonner-Weir S, Sharma ACurrent opinion in organ transplantationRegenerating pancreatic beta-cells: plasticity of adult pancreatic cells and the feasibility of in-vivo neogenesis. Curr Opin Organ Transplant. 2010 Feb; 15(1):79-85.Curr Opin Organ Transplant2010-02-01T00:00:002010Regenerating pancreatic beta-cells: plasticity of adult pancreatic cells and the feasibility of in-vivo neogenesis.12115867Bonner-Weir S, Sharma AThe Journal of pathologyPancreatic stem cells. J Pathol. 2002 Jul; 197(4):519-26.J Pathol2002-07-01T00:00:002002Pancreatic stem cells.2903837Stagner JI, Samols E, Bonner-Weir SDiabetesbeta----alpha----delta pancreatic islet cellular perfusion in dogs. Diabetes. 1988 Dec; 37(12):1715-21.Diabetes1988-12-01T00:00:001988beta----alpha----delta pancreatic islet cellular perfusion in dogs.10907122Vasir B, Reitz P, Xu G, Sharma A, Bonner-Weir S, Weir GCDiabetologiaEffects of diabetes and hypoxia on gene markers of angiogenesis (HGF, cMET, uPA and uPAR, TGF-alpha, TGF-beta, bFGF and Vimentin) in cultured and transplanted rat islets. Diabetologia. 2000 Jun; 43(6):763-72.Diabetologia2000-06-01T00:00:002000Effects of diabetes and hypoxia on gene markers of angiogenesis (HGF, cMET, uPA and uPAR, TGF-alpha, TGF-beta, bFGF and Vimentin) in cultured and transplanted rat islets.10965911Uysal KT, Scheja L, Wiesbrock SM, Bonner-Weir S, Hotamisligil GSEndocrinologyImproved glucose and lipid metabolism in genetically obese mice lacking aP2. Endocrinology. 2000 Sep; 141(9):3388-96.Endocrinology2000-09-01T00:00:002000Improved glucose and lipid metabolism in genetically obese mice lacking aP2.11272199Sharma A, Taneja M, Rietz P, Weitekamp J, Bonner-Weir SDiabetesNovel pancreatic precursor cell lines for studying beta-cell differentiation. Diabetes. 2001 Feb; 50 Suppl 1:S42-3.Diabetes2001-02-01T00:00:002001Novel pancreatic precursor cell lines for studying beta-cell differentiation.12502495Omer A, Duvivier-Kali VF, Trivedi N, Wilmot K, Bonner-Weir S, Weir GCDiabetesSurvival and maturation of microencapsulated porcine neonatal pancreatic cell clusters transplanted into immunocompetent diabetic mice. Diabetes. 2003 Jan; 52(1):69-75.Diabetes2003-01-01T00:00:002003Survival and maturation of microencapsulated porcine neonatal pancreatic cell clusters transplanted into immunocompetent diabetic mice.8625927Noma Y, Bonner-Weir S, Latimer JB, Davalli AM, Weir GCEndocrinologyTranslocation of glucokinase in pancreatic beta-cells during acute and chronic hyperglycemia. Endocrinology. 1996 Apr; 137(4):1485-91.Endocrinology1996-04-01T00:00:001996Translocation of glucokinase in pancreatic beta-cells during acute and chronic hyperglycemia.16049320Inada A, Nagai K, Arai H, Miyazaki J, Nomura K, Kanamori H, Toyokuni S, Yamada Y, Bonner-Weir S, Weir GC, Fukatsu A, Seino YThe American journal of pathologyEstablishment of a diabetic mouse model with progressive diabetic nephropathy. Am J Pathol. 2005 Aug; 167(2):327-36.Am J Pathol2005-08-01T00:00:002005Establishment of a diabetic mouse model with progressive diabetic nephropathy.18073315Marselli L, Thorne J, Ahn YB, Omer A, Sgroi DC, Libermann T, Otu HH, Sharma A, Bonner-Weir S, Weir GCThe Journal of clinical endocrinology and metabolismGene expression of purified beta-cell tissue obtained from human pancreas with laser capture microdissection. J Clin Endocrinol Metab. 2008 Mar; 93(3):1046-53.J Clin Endocrinol Metab2007-12-11T00:00:002007Gene expression of purified beta-cell tissue obtained from human pancreas with laser capture microdissection.18727153Akashi T, Shigematsu H, Hamamoto Y, Iwasaki H, Yatoh S, Bonner-Weir S, Akashi K, Weir GCDiabetes/metabolism research and reviewsBone marrow or foetal liver cells fail to induce islet regeneration in diabetic Akita mice. Diabetes Metab Res Rev. 2008 Oct; 24(7):585-90.Diabetes Metab Res Rev2008-10-01T00:00:002008Bone marrow or foetal liver cells fail to induce islet regeneration in diabetic Akita mice.19131571Emamaullee JA, Merani S, Toso C, Kin T, Al-Saif F, Truong W, Pawlick R, Davis J, Edgar R, Lock J, Bonner-Weir S, Knudsen LB, Shapiro AMEndocrinologyPorcine marginal mass islet autografts resist metabolic failure over time and are enhanced by early treatment with liraglutide. Endocrinology. 2009 May; 150(5):2145-52.Endocrinology2009-01-08T00:00:002009Porcine marginal mass islet autografts resist metabolic failure over time and are enhanced by early treatment with liraglutide.19851748Katsuta H, Akashi T, Katsuta R, Nagaya M, Kim D, Arinobu Y, Hara M, Bonner-Weir S, Sharma AJ, Akashi K, Weir GCDiabetologiaSingle pancreatic beta cells co-express multiple islet hormone genes in mice. Diabetologia. 2010 Jan; 53(1):128-38.Diabetologia2009-10-23T00:00:002009Single pancreatic beta cells co-express multiple islet hormone genes in mice.2642434Bonner-Weir S, Deery D, Leahy JL, Weir GCDiabetesCompensatory growth of pancreatic beta-cells in adult rats after short-term glucose infusion. Diabetes. 1989 Jan; 38(1):49-53.Diabetes1989-01-01T00:00:001989Compensatory growth of pancreatic beta-cells in adult rats after short-term glucose infusion.17299998Noguchi H, Xu G, Matsumoto S, Kaneto H, Kobayashi N, Bonner-Weir S, Hayashi SCell transplantationInduction of pancreatic stem/progenitor cells into insulin-producing cells by adenoviral-mediated gene transfer technology. Cell Transplant. 2006; 15(10):929-38.Cell Transplant2006-01-01T00:00:002006Induction of pancreatic stem/progenitor cells into insulin-producing cells by adenoviral-mediated gene transfer technology.17563059King AJ, Fernandes JR, Hollister-Lock J, Nienaber CE, Bonner-Weir S, Weir GCDiabetesNormal relationship of beta- and non-beta-cells not needed for successful islet transplantation. Diabetes. 2007 Sep; 56(9):2312-8.Diabetes2007-06-11T00:00:002007Normal relationship of beta- and non-beta-cells not needed for successful islet transplantation.18407189Bonner-Weir S, Smith FETrends in endocrinology and metabolism: TEMIslet cell growth and the growth factors involved. Trends Endocrinol Metab. 1994 Mar; 5(2):60-4.Trends Endocrinol Metab1994-03-01T00:00:001994Islet cell growth and the growth factors involved.23197762Lysy PA, Weir GC, Bonner-Weir SStem cells translational medicineConcise review: pancreas regeneration: recent advances and perspectives. Stem Cells Transl Med. 2012 Feb; 1(2):150-9.Stem Cells Transl Med2012-01-26T00:00:002012Concise review: pancreas regeneration: recent advances and perspectives.3033857Gotoh M, Maki T, Satomi S, Porter J, Bonner-Weir S, O'Hara CJ, Monaco APTransplantationReproducible high yield of rat islets by stationary in vitro digestion following pancreatic ductal or portal venous collagenase injection. Transplantation. 1987 May; 43(5):725-30.Transplantation1987-05-01T00:00:001987Reproducible high yield of rat islets by stationary in vitro digestion following pancreatic ductal or portal venous collagenase injection.Authorship 12030748450059Montaña E, Bonner-Weir S, Weir GCThe Journal of clinical investigationBeta cell mass and growth after syngeneic islet cell transplantation in normal and streptozocin diabetic C57BL/6 mice. J Clin Invest. 1993 Mar; 91(3):780-7.J Clin Invest1993-03-01T00:00:001993Beta cell mass and growth after syngeneic islet cell transplantation in normal and streptozocin diabetic C57BL/6 mice.18481956Bonner-Weir S, Inada A, Yatoh S, Li WC, Aye T, Toschi E, Sharma ABiochemical Society transactionsTransdifferentiation of pancreatic ductal cells to endocrine beta-cells. Biochem Soc Trans. 2008 Jun; 36(Pt 3):353-6.Biochem Soc Trans2008-06-01T00:00:002008Transdifferentiation of pancreatic ductal cells to endocrine beta-cells.8320184Schuppin GT, Bonner-Weir S, Montana E, Kaiser N, Weir GCIn vitro cellular & developmental biology. AnimalReplication of adult pancreatic-beta cells cultured on bovine corneal endothelial cell extracellular matrix. In Vitro Cell Dev Biol Anim. 1993 Apr; 29A(4):339-44.In Vitro Cell Dev Biol Anim1993-04-01T00:00:001993Replication of adult pancreatic-beta cells cultured on bovine corneal endothelial cell extracellular matrix.8669096Juang JH, Bonner-Weir S, Ogawa Y, Vacanti JP, Weir GCTransplantationOutcome of subcutaneous islet transplantation improved by polymer device. Transplantation. 1996 Jun 15; 61(11):1557-61.Transplantation1996-06-15T00:00:001996Outcome of subcutaneous islet transplantation improved by polymer device.18852471Koulmanda M, Bhasin M, Hoffman L, Fan Z, Qipo A, Shi H, Bonner-Weir S, Putheti P, Degauque N, Libermann TA, Auchincloss H, Flier JS, Strom TBProceedings of the National Academy of Sciences of the United States of AmericaCurative and beta cell regenerative effects of alpha1-antitrypsin treatment in autoimmune diabetic NOD mice. Proc Natl Acad Sci U S A. 2008 Oct 21; 105(42):16242-7.Proc Natl Acad Sci U S A2008-10-13T00:00:002008Curative and beta cell regenerative effects of alpha1-antitrypsin treatment in autoimmune diabetic NOD mice.3556277Halban PA, Powers SL, George KL, Bonner-Weir SDiabetesSpontaneous reassociation of dispersed adult rat pancreatic islet cells into aggregates with three-dimensional architecture typical of native islets. Diabetes. 1987 Jul; 36(7):783-90.Diabetes1987-07-01T00:00:001987Spontaneous reassociation of dispersed adult rat pancreatic islet cells into aggregates with three-dimensional architecture typical of native islets.20699420Keenan HA, Sun JK, Levine J, Doria A, Aiello LP, Eisenbarth G, Bonner-Weir S, King GLDiabetesResidual insulin production and pancreatic ß-cell turnover after 50 years of diabetes: Joslin Medalist Study. Diabetes. 2010 Nov; 59(11):2846-53.Diabetes2010-08-10T00:00:002010Residual insulin production and pancreatic ß-cell turnover after 50 years of diabetes: Joslin Medalist Study.21698184Marsili A, Aguayo-Mazzucato C, Chen T, Kumar A, Chung M, Lunsford EP, Harney JW, Van-Tran T, Gianetti E, Ramadan W, Chou C, Bonner-Weir S, Larsen PR, Silva JE, Zavacki AMPloS oneMice with a targeted deletion of the type 2 deiodinase are insulin resistant and susceptible to diet induced obesity. PLoS One. 2011; 6(6):e20832.PLoS One2011-06-16T00:00:002011Mice with a targeted deletion of the type 2 deiodinase are insulin resistant and susceptible to diet induced obesity.23305647Aguayo-Mazzucato C, Zavacki AM, Marinelarena A, Hollister-Lock J, El Khattabi I, Marsili A, Weir GC, Sharma A, Larsen PR, Bonner-Weir SDiabetesThyroid hormone promotes postnatal rat pancreatic ß-cell development and glucose-responsive insulin secretion through MAFA. Diabetes. 2013 May; 62(5):1569-80.Diabetes2013-01-10T00:00:002013Thyroid hormone promotes postnatal rat pancreatic ß-cell development and glucose-responsive insulin secretion through MAFA.6115303Bonner-Weir S, Trent DF, Zmachinski CJ, Clore ET, Weir GCMetabolism: clinical and experimentalLimited B cell regeneration in a B cell deficient rat model: studies with dexamethasone. Metabolism. 1981 Sep; 30(9):914-8.Metabolism1981-09-01T00:00:001981Limited B cell regeneration in a B cell deficient rat model: studies with dexamethasone.7701574Davalli AM, Ogawa Y, Ricordi C, Scharp DW, Bonner-Weir S, Weir GCTransplantationA selective decrease in the beta cell mass of human islets transplanted into diabetic nude mice. Transplantation. 1995 Mar 27; 59(6):817-20.Transplantation1995-03-27T00:00:001995A selective decrease in the beta cell mass of human islets transplanted into diabetic nude mice.8029845Davalli AM, Ogawa Y, Scaglia L, Wu YJ, Hollister J, Bonner-Weir S, Weir GCTransplantation proceedingsPorcine islet grafts in diabetic nude mice: dynamic insulin secretion and regulated B-cell mass lower glucose levels to the normal porcine range. Transplant Proc. 1994 Jun; 26(3):1098-9.Transplant Proc1994-06-01T00:00:001994Porcine islet grafts in diabetic nude mice: dynamic insulin secretion and regulated B-cell mass lower glucose levels to the normal porcine range.16132945King A, Lock J, Xu G, Bonner-Weir S, Weir GCDiabetologiaIslet transplantation outcomes in mice are better with fresh islets and exendin-4 treatment. Diabetologia. 2005 Oct; 48(10):2074-9.Diabetologia2005-08-23T00:00:002005Islet transplantation outcomes in mice are better with fresh islets and exendin-4 treatment.16380717Evgenov NV, Medarova Z, Dai G, Bonner-Weir S, Moore ANature medicineIn vivo imaging of islet transplantation. Nat Med. 2006 Jan; 12(1):144-8.Nat Med2005-12-25T00:00:002005In vivo imaging of islet transplantation.7883109Finegood DT, Scaglia L, Bonner-Weir SDiabetesDynamics of beta-cell mass in the growing rat pancreas. Estimation with a simple mathematical model. Diabetes. 1995 Mar; 44(3):249-56.Diabetes1995-03-01T00:00:001995Dynamics of beta-cell mass in the growing rat pancreas. Estimation with a simple mathematical model.8163660Montaña E, Bonner-Weir S, Weir GCThe Journal of clinical investigationTransplanted beta cell response to increased metabolic demand. Changes in beta cell replication and mass. J Clin Invest. 1994 Apr; 93(4):1577-82.J Clin Invest1994-04-01T00:00:001994Transplanted beta cell response to increased metabolic demand. Changes in beta cell replication and mass.20101386O'Sullivan ES, Johnson AS, Omer A, Hollister-Lock J, Bonner-Weir S, Colton CK, Weir GCDiabetologiaRat islet cell aggregates are superior to islets for transplantation in microcapsules. Diabetologia. 2010 May; 53(5):937-945.Diabetologia2010-01-26T00:00:002010Rat islet cell aggregates are superior to islets for transplantation in microcapsules.21788579Weir GC, Bonner-Weir SDiabetesSleeping islets and the relationship between ß-cell mass and function. Diabetes. 2011 Aug; 60(8):2018-9.Diabetes2011-08-01T00:00:002011Sleeping islets and the relationship between ß-cell mass and function.6232285Permutt MA, Kakita K, Malinas P, Karl I, Bonner-Weir S, Weir G, Giddings SJThe Journal of clinical investigationAn in vivo analysis of pancreatic protein and insulin biosynthesis in a rat model for non-insulin-dependent diabetes. J Clin Invest. 1984 May; 73(5):1344-50.J Clin Invest1984-05-01T00:00:001984An in vivo analysis of pancreatic protein and insulin biosynthesis in a rat model for non-insulin-dependent diabetes.3289893Halban PA, Powers SL, George KL, Bonner-Weir SEndocrinologyAltered differentiated cell surface properties of transformed (RINm5F) compared with native adult rat pancreatic B cells. Endocrinology. 1988 Jul; 123(1):113-9.Endocrinology1988-07-01T00:00:001988Altered differentiated cell surface properties of transformed (RINm5F) compared with native adult rat pancreatic B cells.3897755Colella RM, Bonner-Weir S, Braunstein LP, Schwalke M, Weir GCLife sciencesPancreatic islets of variable size--insulin secretion and glucose utilization. Life Sci. 1985 Sep 16; 37(11):1059-65.Life Sci1985-09-16T00:00:001985Pancreatic islets of variable size--insulin secretion and glucose utilization.7926308Juang JH, Bonner-Weir S, Wu YJ, Weir GCDiabetesBeneficial influence of glycemic control upon the growth and function of transplanted islets. Diabetes. 1994 Nov; 43(11):1334-9.Diabetes1994-11-01T00:00:001994Beneficial influence of glycemic control upon the growth and function of transplanted islets.8146438Bonner-Weir SRecent progress in hormone researchRegulation of pancreatic beta-cell mass in vivo. Recent Prog Horm Res. 1994; 49:91-104.Recent Prog Horm Res1994-01-01T00:00:001994Regulation of pancreatic beta-cell mass in vivo.8539901Weitgasser R, Davalli AM, Napoli R, Capotorto JV, Finegood DT, Bonner-Weir S, Weir GCTransplantation proceedingsLong-term normalization of GLUT 4 protein content in skeletal muscle of streptozotocin-diabetic Lewis rats after islet transplantation. Transplant Proc. 1995 Dec; 27(6):3184-5.Transplant Proc1995-12-01T00:00:001995Long-term normalization of GLUT 4 protein content in skeletal muscle of streptozotocin-diabetic Lewis rats after islet transplantation.1707061Meyerovitch J, Rothenberg P, Shechter Y, Bonner-Weir S, Kahn CRThe Journal of clinical investigationVanadate normalizes hyperglycemia in two mouse models of non-insulin-dependent diabetes mellitus. J Clin Invest. 1991 Apr; 87(4):1286-94.J Clin Invest1991-04-01T00:00:001991Vanadate normalizes hyperglycemia in two mouse models of non-insulin-dependent diabetes mellitus.7851694Smith FE, Bonner-Weir S, Leahy JL, Laufgraben MJ, Ogawa Y, Rosen KM, Villa-Komaroff LDiabetologiaPancreatic Reg/pancreatic stone protein (PSP) gene expression does not correlate with beta-cell growth and regeneration in rats. Diabetologia. 1994 Oct; 37(10):994-9.Diabetologia1994-10-01T00:00:001994Pancreatic Reg/pancreatic stone protein (PSP) gene expression does not correlate with beta-cell growth and regeneration in rats.16644676López-Avalos MD, Duvivier-Kali VF, Xu G, Bonner-Weir S, Sharma A, Weir GCDiabetesEvidence for a role of the ubiquitin-proteasome pathway in pancreatic islets. Diabetes. 2006 May; 55(5):1223-31.Diabetes2006-05-01T00:00:002006Evidence for a role of the ubiquitin-proteasome pathway in pancreatic islets.6134752Bonner-Weir S, Trent DF, Weir GCThe Journal of clinical investigationPartial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release. J Clin Invest. 1983 Jun; 71(6):1544-53.J Clin Invest1983-06-01T00:00:001983Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release.6203798Leahy JL, Bonner-Weir S, Weir GCDiabetesAbnormal glucose regulation of insulin secretion in models of reduced B-cell mass. Diabetes. 1984 Jul; 33(7):667-73.Diabetes1984-07-01T00:00:001984Abnormal glucose regulation of insulin secretion in models of reduced B-cell mass.19281773Dodge R, Loomans C, Sharma A, Bonner-Weir SDifferentiation; research in biological diversityDevelopmental pathways during in vitro progression of human islet neogenesis. Differentiation. 2009 Feb; 77(2):135-47.Differentiation2008-11-06T00:00:002008Developmental pathways during in vitro progression of human islet neogenesis.Authorship 115913320085728Kushner JA, Weir GC, Bonner-Weir SCell metabolismDuctal origin hypothesis of pancreatic regeneration under attack. Cell Metab. 2010 Jan; 11(1):2-3.Cell Metab2010-01-01T00:00:002010Ductal origin hypothesis of pancreatic regeneration under attack.21370199Suzuki K, Colton CK, Bonner-Weir S, Hollister J, Weir GCMethods in molecular medicineEstimating number and volume of islets transplanted within a planar immunobarrier diffusion chamber. Methods Mol Med. 1999; 18:497-505.Methods Mol Med1999-01-01T00:00:001999Estimating number and volume of islets transplanted within a planar immunobarrier diffusion chamber.Authorship 1120570430548444Rezanejad H, Lock JH, Sullivan BA, Bonner-Weir SCurrent protocols in cell biologyGeneration of Pancreatic Ductal Organoids and Whole-Mount Immunostaining of Intact Organoids. Curr Protoc Cell Biol. 2019 06; 83(1):e82.Curr Protoc Cell Biol2018-12-12T00:00:002018Generation of Pancreatic Ductal Organoids and Whole-Mount Immunostaining of Intact Organoids.6986987Bonner-Weir S, Like AACell and tissue researchA dual population of islets of Langerhans in bovine pancreas. Cell Tissue Res. 1980; 206(1):157-70.Cell Tissue Res1980-01-01T00:00:001980A dual population of islets of Langerhans in bovine pancreas.8200983Liang Y, Bonner-Weir S, Wu YJ, Berdanier CD, Berner DK, Efrat S, Matschinsky FMThe Journal of clinical investigationIn situ glucose uptake and glucokinase activity of pancreatic islets in diabetic and obese rodents. J Clin Invest. 1994 Jun; 93(6):2473-81.J Clin Invest1994-06-01T00:00:001994In situ glucose uptake and glucokinase activity of pancreatic islets in diabetic and obese rodents.9844324Weir GC, Bonner-Weir SJournal of the American Optometric AssociationIslet transplantation as a treatment for diabetes. J Am Optom Assoc. 1998 Nov; 69(11):727-32.J Am Optom Assoc1998-11-01T00:00:001998Islet transplantation as a treatment for diabetes.10089884Westphal CH, Muller L, Zhou A, Zhu X, Bonner-Weir S, Schambelan M, Steiner DF, Lindberg I, Leder PCellThe neuroendocrine protein 7B2 is required for peptide hormone processing in vivo and provides a novel mechanism for pituitary Cushing's disease. Cell. 1999 Mar 05; 96(5):689-700.Cell1999-03-05T00:00:001999The neuroendocrine protein 7B2 is required for peptide hormone processing in vivo and provides a novel mechanism for pituitary Cushing's disease.12028980Wolpert HA, Faradji RN, Bonner-Weir S, Lipes MABMJ (Clinical research ed.)Metabolic decompensation in pump users due to lispro insulin precipitation. BMJ. 2002 May 25; 324(7348):1253.BMJ2002-05-25T00:00:002002Metabolic decompensation in pump users due to lispro insulin precipitation.Authorship 109322040383McCulloch DK, Koerker DJ, Kahn SE, Bonner-Weir S, Palmer JPDiabetesCorrelations of in vivo beta-cell function tests with beta-cell mass and pancreatic insulin content in streptozocin-administered baboons. Diabetes. 1991 Jun; 40(6):673-9.Diabetes1991-06-01T00:00:001991Correlations of in vivo beta-cell function tests with beta-cell mass and pancreatic insulin content in streptozocin-administered baboons.19817791Weir GC, Marselli L, Marchetti P, Katsuta H, Jung MH, Bonner-Weir SDiabetes, obesity & metabolismTowards better understanding of the contributions of overwork and glucotoxicity to the beta-cell inadequacy of type 2 diabetes. Diabetes Obes Metab. 2009 Nov; 11 Suppl 4:82-90.Diabetes Obes Metab2009-11-01T00:00:002009Towards better understanding of the contributions of overwork and glucotoxicity to the beta-cell inadequacy of type 2 diabetes.2669799Ziegler AG, Vardi P, Gross DJ, Bonner-Weir S, Villa-Komaroff L, Halban PA, Ikegami H, Soeldner JS, Eisenbarth GSJournal of autoimmunityProduction of insulin antibodies by mice rejecting insulin transfected cells. J Autoimmun. 1989 Jun; 2(3):219-27.J Autoimmun1989-06-01T00:00:001989Production of insulin antibodies by mice rejecting insulin transfected cells.Authorship 1155826D016381Procedures1587420.666081Islets of Langerhans TransplantationD010179Anatomy64916780.589315PancreasD050417Anatomy3048890.563048Insulin-Secreting CellsD010183Anatomy1443280.838322Pancreatic DuctsD007515Anatomy33113370.606847Islets of LangerhansMedicinePediatricsNephrologyJoslinEndocrinologyBeth Israel Deaconess Medical CenterBoston Children's HospitalJoslin Diabetes CenterMassachusetts General HospitalGCW1GordonWeirGordon Campbell Weir, M.D.42.33839600000000-71.1084030000000076093Weir, GordonProfessor of MedicinePF15PaoloFiorinaPaolo Fiorina, M.D.42.33710500000000-71.1023170000000028579Fiorina, PaoloLecturer on Pediatrics, Part-timeOH1OsamaHamdyOsama Hamdy, M.B.,B.Ch., M.D.42.33839600000000-71.1084030000000014853Hamdy, OsamaAssociate Professor of MedicineASK2AndrzejKrolewskiAndrzej Stefan Krolewski, M.D., Ph.D.42.33839600000000-71.1084030000000049343Krolewski, AndrzejProfessor of MedicineAuthorship 11589681031155496Aguayo-Mazzucato C, Andle J, Lee TB, Midha A, Talemal L, Chipashvili V, Hollister-Lock J, van Deursen J, Weir G, Bonner-Weir SCell metabolismAcceleration of ß Cell Aging Determines Diabetes and Senolysis Improves Disease Outcomes. Cell Metab. 2019 07 02; 30(1):129-142.e4.Cell Metab2019-05-30T00:00:002019Acceleration of ß Cell Aging Determines Diabetes and Senolysis Improves Disease Outcomes.CRK3C.KahnC. Ronald Kahn, M.D.42.33839600000000-71.1084030000000084269Kahn, C.Mary K. Iacocca Professor of MedicineJFH1JoelHabenerJoel Francis Habener, M.D.42.36241700000000-71.0689370000000044907Habener, JoelProfessor of MedicineLJG1LaurieGoodyearLaurie Joy Goodyear, Ph.D.42.33839600000000-71.1084030000000025240Goodyear, LaurieProfessor of MedicineET13ElenaToschiElena Toschi, M.D.54767Toschi, ElenaAssistant Professor of Medicine11288selected publications13.5220.00117355702research areas21.46220.0060301959coauthor of460.76924.991160similar toRNK1RohitKulkarniRohit N. Kulkarni, M.D., Ph.D.42.33839600000000-71.108403000000009138Kulkarni, RohitProfessor of MedicineCA43CristinaAguayo-MazzucatoCristina Aguayo-Mazzucato, M.D., Ph.D.42.33839600000000-71.1084030000000066986Aguayo-Mazzucato, CristinaAssistant Professor of MedicineAuthorship 11683811031264968Yu MG, Keenan HA, Shah HS, Frodsham SG, Pober D, He Z, Wolfson EA, D'Eon S, Tinsley LJ, Bonner-Weir S, Pezzolesi MG, King GLThe Journal of clinical investigationResidual ß cell function and monogenic variants in long-duration type 1 diabetes patients. J Clin Invest. 2019 07 02; 129(8):3252-3263.J Clin Invest2019-07-02T00:00:002019Residual ß cell function and monogenic variants in long-duration type 1 diabetes patients.JS804JeanSchafferJean Schaffer, M.D.183262Schaffer, JeanOry Family Professor of MedicineAuthorship 119006Authorship 1634253Authorship 1111834Authorship 1203736131740743Bonner-Weir SNature reviews. EndocrinologyThe islets of Langerhans continue to reveal their secrets. Nat Rev Endocrinol. 2020 02; 16(2):73-74.Nat Rev Endocrinol2020-02-01T00:00:002020The islets of Langerhans continue to reveal their secrets.true1Professor of MedicineProfessor of Medicinetrue1Professor of MedicineProfessor of Medicinetrue1Professor of MedicineProfessor of Medicinetrue1Mary K. Iacocca Professor of MedicineMary K. Iacocca Professor of Medicinetrue1Professor of MedicineProfessor of Medicinetrue1Professor of MedicineProfessor of Medicinetrue1Professor of MedicineProfessor of MedicineAuthorship 1608125AC631AbigaelCheruiyotAbigael Cheruiyot, Ph.D.186727Cheruiyot, AbigaelResearch Fellow in MedicineAuthorship 1737801Authorship 1572892Authorship 1222884332006519Weir GC, Gaglia J, Bonner-Weir SThe lancet. Diabetes & endocrinologyInadequate ß-cell mass is essential for the pathogenesis of type 2 diabetes. Lancet Diabetes Endocrinol. 2020 03; 8(3):249-256.Lancet Diabetes Endocrinol2020-01-29T00:00:002020Inadequate ß-cell mass is essential for the pathogenesis of type 2 diabetes.true1Assistant Professor of MedicineAssistant Professor of Medicinetrue1Assistant Professor of MedicineAssistant Professor of MedicineAuthorship 1236434532244186Ebrahimi AG, Hollister-Lock J, Sullivan BA, Tsuchida R, Bonner-Weir S, Weir GCMolecular metabolismBeta cell identity changes with mild hyperglycemia: Implications for function, growth, and vulnerability. Mol Metab. 2020 05; 35:100959.Mol Metab2020-02-14T00:00:002020Beta cell identity changes with mild hyperglycemia: Implications for function, growth, and vulnerability.Authorship 1243072332333872Weir GC, Gaglia J, Bonner-Weir SThe lancet. Diabetes & endocrinologyß-cell secretory dysfunction: a key cause of type 2 diabetes - Authors' reply. Lancet Diabetes Endocrinol. 2020 05; 8(5):370-371.Lancet Diabetes Endocrinol2020-05-01T00:00:002020ß-cell secretory dysfunction: a key cause of type 2 diabetes - Authors' reply.Authorship 185631Authorship 1303285Authorship 1329073Authorship 1335221Authorship 1437582Authorship 1666852Authorship 168013Authorship 184131Authorship 1562644Authorship 1948097Authorship 1964516Authorship 1336437633674410Midha A, Pan H, Abarca C, Andle J, Carapeto P, Bonner-Weir S, Aguayo-Mazzucato CDiabetesUnique Human and Mouse ß-Cell Senescence-Associated Secretory Phenotype (SASP) Reveal Conserved Signaling Pathways and Heterogeneous Factors. Diabetes. 2021 05; 70(5):1098-1116.Diabetes2021-03-05T00:00:002021Unique Human and Mouse ß-Cell Senescence-Associated Secretory Phenotype (SASP) Reveal Conserved Signaling Pathways and Heterogeneous Factors.Authorship 1344022233786336Weir GC, Bonner-Weir SCellR4-- repair, replacement, regeneration, & reprogrammingWhy pancreatic islets should be regarded and regulated like organs. CellR4 Repair Replace Regen Reprogram. 2021; 9.CellR4 Repair Replace Regen Reprogram2021-03-16T00:00:002021Why pancreatic islets should be regarded and regulated like organs.Authorship 1572562Authorship 1363798234128470Weir GC, Bonner-Weir SThe Journal of clinical investigationReduced glucose-induced first-phase insulin release is a danger signal that predicts diabetes. J Clin Invest. 2021 06 15; 131(12).J Clin Invest2021-06-15T00:00:002021Reduced glucose-induced first-phase insulin release is a danger signal that predicts diabetes.Authorship 176015Authorship 1996512Authorship 1643768Authorship 1662627Authorship 1394711334480921Weir GC, Butler PC, Bonner-Weir SMetabolism: clinical and experimentalThe ß-cell glucose toxicity hypothesis: Attractive but difficult to prove. Metabolism. 2021 11; 124:154870.Metabolism2021-09-01T00:00:002021The ß-cell glucose toxicity hypothesis: Attractive but difficult to prove.Authorship 200422Authorship 2033551Authorship 2151963Authorship 1410768134739830Bonner-Weir SCell stem cellNew evidence for adult beta cell neogenesis. Cell Stem Cell. 2021 11 04; 28(11):1889-1890.Cell Stem Cell2021-11-04T00:00:002021New evidence for adult beta cell neogenesis.Authorship 192080535017647Kim OH, Kang GH, Hur J, Lee J, Jung Y, Hong IS, Lee H, Seo SY, Lee DH, Lee CS, Lee IK, Bonner-Weir S, Lee J, Park YJ, Kim H, Shoelson SE, Oh BCCell death and differentiationExternalized phosphatidylinositides on apoptotic cells are eat-me signals recognized by CD14. Cell Death Differ. 2022 07; 29(7):1423-1432.Cell Death Differ2022-01-11T00:00:002022Externalized phosphatidylinositides on apoptotic cells are eat-me signals recognized by CD14.Authorship 142641212Authorship 2551794Authorship 2767338Authorship 34853913Authorship 3904798Authorship 4326942Authorship 1493090235970893Rubin de Celis MF, Bonner-Weir SNature reviews. EndocrinologyGlucagon receptor antagonists might stimulate ß-cell expansion. Nat Rev Endocrinol. 2022 11; 18(11):659-660.Nat Rev Endocrinol2022-11-01T00:00:002022Glucagon receptor antagonists might stimulate ß-cell expansion.Authorship 4386506Authorship 1504702636375063Rubin de Celis MF, Garcia-Martin R, Syed I, Lee J, Aguayo-Mazzucato C, Bonner-Weir S, Kahn BBProceedings of the National Academy of Sciences of the United States of AmericaPAHSAs reduce cellular senescence and protect pancreatic beta cells from metabolic stress through regulation of Mdm2/p53. Proc Natl Acad Sci U S A. 2022 11 22; 119(47):e2206923119.Proc Natl Acad Sci U S A2022-11-14T00:00:002022PAHSAs reduce cellular senescence and protect pancreatic beta cells from metabolic stress through regulation of Mdm2/p53.Authorship 4630003Authorship 2441234Authorship 214966Authorship 1942253Authorship 4712977Authorship 4765265Authorship 2088989Authorship 2618472Authorship 15607082Authorship 1573603237160100Rubin de Celis MF, Bonner-Weir SDevelopmental cellImproving stem cell-derived pancreatic islets using single-cell multi-inferred regulomes. Dev Cell. 2023 05 08; 58(9):725-726.Dev Cell2023-05-08T00:00:002023Improving stem cell-derived pancreatic islets using single-cell multi-inferred regulomes.37409234Weir GC, Bonner-Weir SFrontiers in endocrinologyInduction of remission in diabetes by lowering blood glucose. Front Endocrinol (Lausanne). 2023; 14:1213954.Front Endocrinol (Lausanne)2023-06-20T00:00:002023Induction of remission in diabetes by lowering blood glucose.Authorship 3664275Authorship 15967096Authorship 1597199237808767Cheruiyot A, Hollister-Lock J, Sullivan B, Pan H, Dreyfuss JM, Bonner-Weir S, Schaffer JEbioRxiv : the preprint server for biologySustained hyperglycemia specifically targets translation of mRNAs for insulin secretion. bioRxiv. 2023 Sep 29.bioRxiv2023-09-29T00:00:002023Sustained hyperglycemia specifically targets translation of mRNAs for insulin secretion.37822597Rubin de Celis MF, Bonner-Weir SFrontiers in endocrinologyReversing and modulating cellular senescence in beta cells, a new field of opportunities to treat diabetes. Front Endocrinol (Lausanne). 2023; 14:1217729.Front Endocrinol (Lausanne)2023-09-26T00:00:002023Reversing and modulating cellular senescence in beta cells, a new field of opportunities to treat diabetes.true1Research Fellow in MedicineResearch Fellow in Medicinetrue1Associate Professor of MedicineAssociate Professor of MedicineAuthorship 16823311Authorship 473111Authorship 16078742Authorship 1608518638032734Cheruiyot A, Hollister-Lock J, Sullivan B, Pan H, Dreyfuss JM, Bonner-Weir S, Schaffer JEThe Journal of clinical investigationSustained hyperglycemia specifically targets translation of mRNAs for insulin secretion. J Clin Invest. 2023 Nov 30; 134(3).J Clin Invest2023-11-30T00:00:002023Sustained hyperglycemia specifically targets translation of mRNAs for insulin secretion.37983524Weir GC, Bonner-Weir SDiabetesConflicting Views About Interactions Between Pancreatic a-Cells and ß-Cells. Diabetes. 2023 12 01; 72(12):1741-1747.Diabetes2023-12-01T00:00:002023Conflicting Views About Interactions Between Pancreatic a-Cells and ß-Cells.Authorship 5024875Authorship 1747832true1Ory Family Professor of MedicineOry Family Professor of Medicinetrue1Lecturer on Pediatrics, Part-timeLecturer on Pediatrics, Part-timeAuthorship 1546694Authorship 1561063Authorship 2976265Authorship 3073284Authorship 4202245Authorship 4311747Authorship 4537266Authorship 2589322Authorship 2767656Authorship 2838464Authorship 3275625Authorship 4873452Authorship 6572931Authorship 65371510Authorship 665265723569174Spijker HS, Ravelli RB, Mommaas-Kienhuis AM, van Apeldoorn AA, Engelse MA, Zaldumbide A, Bonner-Weir S, Rabelink TJ, Hoeben RC, Clevers H, Mummery CL, Carlotti F, de Koning EJDiabetesConversion of mature human ß-cells into glucagon-producing a-cells. Diabetes. 2013 Jul; 62(7):2471-80.Diabetes2013-04-08T00:00:002013Conversion of mature human ß-cells into glucagon-producing a-cells.23804276Bonner-Weir S, Guo L, Li WC, Ouziel-Yahalom L, Lysy PA, Weir GC, Sharma AThe review of diabetic studies : RDSIslet neogenesis: a possible pathway for beta-cell replenishment. Rev Diabet Stud. 2012; 9(4):407-16.Rev Diabet Stud2012-12-28T00:00:002012Islet neogenesis: a possible pathway for beta-cell replenishment.Authorship 1983622Authorship 20913011Authorship 76936Authorship 1943952Authorship 2289891Authorship 6759853Authorship 6739739Authorship 678628623775765Guo L, Inada A, Aguayo-Mazzucato C, Hollister-Lock J, Fujitani Y, Weir GC, Wright CV, Sharma A, Bonner-Weir SDiabetesPDX1 in ducts is not required for postnatal formation of ß-cells but is necessary for their subsequent maturation. Diabetes. 2013 Oct; 62(10):3459-68.Diabetes2013-06-17T00:00:002013PDX1 in ducts is not required for postnatal formation of ß-cells but is necessary for their subsequent maturation.23991053Wu F, Guo L, Jakubowski A, Su L, Li WC, Bonner-Weir S, Burkly LCPloS oneTNF-like weak inducer of apoptosis (TWEAK) promotes beta cell neogenesis from pancreatic ductal epithelium in adult mice. PLoS One. 2013; 8(8):e72132.PLoS One2013-08-26T00:00:002013TNF-like weak inducer of apoptosis (TWEAK) promotes beta cell neogenesis from pancreatic ductal epithelium in adult mice.23925431Lysy PA, Weir GC, Bonner-Weir SCurrent diabetes reportsMaking ß cells from adult cells within the pancreas. Curr Diab Rep. 2013 Oct; 13(5):695-703.Curr Diab Rep2013-10-01T00:00:002013Making ß cells from adult cells within the pancreas.Authorship 2654307Authorship 2917964Authorship 691895824204831King AJ, Guo Y, Cai D, Hollister-Lock J, Morris B, Salvatori A, Corbett JA, Bonner-Weir S, Shoelson SE, Weir GCPloS oneSustained NF-?B activation and inhibition in ß-cells have minimal effects on function and islet transplant outcomes. PLoS One. 2013; 8(10):e77452.PLoS One2013-10-18T00:00:002013Sustained NF-?B activation and inhibition in ß-cells have minimal effects on function and islet transplant outcomes.Authorship 695067724029238Cavelti-Weder C, Shtessel M, Reuss JE, Jermendy A, Yamada T, Caballero F, Bonner-Weir S, Weir GCEndocrinologyPancreatic duct ligation after almost complete ß-cell loss: exocrine regeneration but no evidence of ß-cell regeneration. Endocrinology. 2013 Dec; 154(12):4493-502.Endocrinology2013-09-12T00:00:002013Pancreatic duct ligation after almost complete ß-cell loss: exocrine regeneration but no evidence of ß-cell regeneration.Authorship 695534624183936He KH, Juhl K, Karadimos M, El Khattabi I, Fitzpatrick C, Bonner-Weir S, Sharma ADevelopmental biologyDifferentiation of pancreatic endocrine progenitors reversibly blocked by premature induction of MafA. Dev Biol. 2014 Jan 01; 385(1):2-12.Dev Biol2013-10-29T00:00:002013Differentiation of pancreatic endocrine progenitors reversibly blocked by premature induction of MafA.Authorship 3725821Authorship 178052Authorship 3863554Authorship 1844463Authorship 2380212Authorship 394686Authorship 4151188Authorship 2890653Authorship 33097611Authorship 7118324Authorship 7151271123321263Caballero F, Siniakowicz K, Hollister-Lock J, Duran L, Katsuta H, Yamada T, Lei J, Deng S, Westermark GT, Markmann J, Bonner-Weir S, Weir GCCell transplantationBirth and death of human ß-cells in pancreases from cadaver donors, autopsies, surgical specimens, and islets transplanted into mice. Cell Transplant. 2014 Feb; 23(2):139-51.Cell Transplant2013-01-02T00:00:002013Birth and death of human ß-cells in pancreases from cadaver donors, autopsies, surgical specimens, and islets transplanted into mice.24222349Chadwick KD, Fletcher AM, Parrula MC, Bonner-Weir S, Mangipudy RS, Janovitz E, Graziano MJ, Roy D, Reilly TPDiabetesOccurrence of spontaneous pancreatic lesions in normal and diabetic rats: a potential confounding factor in the nonclinical assessment of GLP-1-based therapies. Diabetes. 2014 Apr; 63(4):1303-14.Diabetes2013-11-12T00:00:002013Occurrence of spontaneous pancreatic lesions in normal and diabetic rats: a potential confounding factor in the nonclinical assessment of GLP-1-based therapies.Authorship 2203687Authorship 3248824Authorship 2434572Authorship 2515024Authorship 2536046Authorship 256421524356710Weir GC, Aguayo-Mazzucato C, Bonner-Weir SIsletsß-cell dedifferentiation in diabetes is important, but what is it? Islets. 2013 Sep-Dec; 5(5):233-7.Islets2013-12-19T00:00:002013ß-cell dedifferentiation in diabetes is important, but what is it?Authorship 1839561Authorship 7315173Authorship 1670144Authorship 737386124400596Bonner-Weir S, In't Veld PA, Weir GCDiabetes, obesity & metabolismReanalysis of study of pancreatic effects of incretin therapy: methodological deficiencies. Diabetes Obes Metab. 2014 Jul; 16(7):661-6.Diabetes Obes Metab2014-01-29T00:00:002014Reanalysis of study of pancreatic effects of incretin therapy: methodological deficiencies.Authorship 3399802Authorship 360191Authorship 3677563Authorship 3076333Authorship 3191894Authorship 3513982Authorship 4541662Authorship 4596725Authorship 5356012Authorship 3617561Authorship 3895626Authorship 3905582Authorship 4325141Authorship 4552364Authorship 37605812Authorship 771128625417115Gusarova V, Alexa CA, Na E, Stevis PE, Xin Y, Bonner-Weir S, Cohen JC, Hobbs HH, Murphy AJ, Yancopoulos GD, Gromada JCellANGPTL8/betatrophin does not control pancreatic beta cell expansion. Cell. 2014 Oct 23; 159(3):691-6.Cell2014-10-23T00:00:002014ANGPTL8/betatrophin does not control pancreatic beta cell expansion.Authorship 547982Authorship 5404507Authorship 903218Authorship 2829642Authorship 5085474Authorship 4059658Authorship 38963Authorship 4719565Authorship 4543855Authorship 470191Authorship 5359506Authorship 5448175Authorship 4010564Authorship 2275884Authorship 186706Authorship 2402651Authorship 88496Authorship 986777Authorship 471112Authorship 2139772Authorship 749557Authorship 2432372Authorship 3062003Authorship 2729724Authorship 2432093Authorship 3865631Authorship 39764512Authorship 3103752Authorship 3472733Authorship 212582Authorship 4617011Authorship 1999683Authorship 2267862Authorship 5690642Authorship 65707Authorship 29666711Authorship 4069687Authorship 2694965Authorship 2414762Authorship 4577636Authorship 2283584Authorship 2256294Authorship 2608067Authorship 3635197Authorship 3695402Authorship 3816726Authorship 4842106Authorship 4871702Authorship 5710203Authorship 4657454Authorship 3142732Authorship 3632762Authorship 4142356Authorship 4382033Authorship 5255951Authorship 7894163Authorship 799703925488899Sullivan BA, Hollister-Lock J, Bonner-Weir S, Weir GCDiabetesReduced Ki67 Staining in the Postmortem State Calls Into Question Past Conclusions About the Lack of Turnover of Adult Human ß-Cells. Diabetes. 2015 May; 64(5):1698-702.Diabetes2014-12-08T00:00:002014Reduced Ki67 Staining in the Postmortem State Calls Into Question Past Conclusions About the Lack of Turnover of Adult Human ß-Cells.25836667Yamada T, Cavelti-Weder C, Caballero F, Lysy PA, Guo L, Sharma A, Li W, Zhou Q, Bonner-Weir S, Weir GCEndocrinologyReprogramming Mouse Cells With a Pancreatic Duct Phenotype to Insulin-Producing ß-Like Cells. Endocrinology. 2015 Jun; 156(6):2029-38.Endocrinology2015-04-02T00:00:002015Reprogramming Mouse Cells With a Pancreatic Duct Phenotype to Insulin-Producing ß-Like Cells.Authorship 3099262Authorship 2771223Authorship 3003049Authorship 3005605Authorship 4022672Authorship 4511785Authorship 5076244Authorship 5174534Authorship 5195795Authorship 5336452Authorship 4340203Authorship 4775982Authorship 4897979Authorship 4942705Authorship 5185203Authorship 52993311Authorship 4836622Authorship 356615Authorship 2963238Authorship 819495125604813Bonner-Weir S, Sullivan BA, Weir GCThe journal of histochemistry and cytochemistry : official journal of the Histochemistry SocietyHuman Islet Morphology Revisited: Human and Rodent Islets Are Not So Different After All. J Histochem Cytochem. 2015 08; 63(8):604-12.J Histochem Cytochem2015-01-20T00:00:002015Human Islet Morphology Revisited: Human and Rodent Islets Are Not So Different After All.Authorship 3793899Authorship 4221148Authorship 4489707Authorship 464221Authorship 5635852Authorship 686229Authorship 93275Authorship 37675112Authorship 3877462Authorship 839461826207953Aguayo-Mazzucato C, DiIenno A, Hollister-Lock J, Cahill C, Sharma A, Weir G, Colton C, Bonner-Weir SThe Journal of clinical endocrinology and metabolismMAFA and T3 Drive Maturation of Both Fetal Human Islets and Insulin-Producing Cells Differentiated From hESC. J Clin Endocrinol Metab. 2015 Oct; 100(10):3651-9.J Clin Endocrinol Metab2015-07-24T00:00:002015MAFA and T3 Drive Maturation of Both Fetal Human Islets and Insulin-Producing Cells Differentiated From hESC.Authorship 4325646Authorship 446421Authorship 843748626540252Nishimura W, Kapoor A, El Khattabi I, Jin W, Yasuda K, Bonner-Weir S, Sharma APloS oneCompensatory Response by Late Embryonic Tubular Epithelium to the Reduction in Pancreatic Progenitors. PLoS One. 2015; 10(11):e0142286.PLoS One2015-11-05T00:00:002015Compensatory Response by Late Embryonic Tubular Epithelium to the Reduction in Pancreatic Progenitors.Authorship 4782145Authorship 4900905Authorship 5103216Authorship 5181573Authorship 5450955Authorship 478571Authorship 5014876Authorship 5137182Authorship 5514553Authorship 804945Authorship 86398311Authorship 8709401025437872Corritore E, Dugnani E, Pasquale V, Misawa R, Witkowski P, Lei J, Markmann J, Piemonti L, Sokal EM, Bonner-Weir S, Lysy PACellular reprogrammingß-Cell differentiation of human pancreatic duct-derived cells after in vitro expansion. Cell Reprogram. 2014 Dec; 16(6):456-66.Cell Reprogram2014-12-01T00:00:002014ß-Cell differentiation of human pancreatic duct-derived cells after in vitro expansion.26693711Cavelti-Weder C, Li W, Zumsteg A, Stemann-Andersen M, Zhang Y, Yamada T, Wang M, Lu J, Jermendy A, Bee YM, Bonner-Weir S, Weir GC, Zhou QDiabetologiaHyperglycaemia attenuates in vivo reprogramming of pancreatic exocrine cells to beta cells in mice. Diabetologia. 2016 Mar; 59(3):522-32.Diabetologia2015-12-23T00:00:002015Hyperglycaemia attenuates in vivo reprogramming of pancreatic exocrine cells to beta cells in mice.Authorship 646726Authorship 76872Authorship 4395982Authorship 4626712Authorship 881173126998806Bonner-Weir S, Aguayo-Mazzucato C, Weir GCUpsala journal of medical sciencesDynamic development of the pancreas from birth to adulthood. Ups J Med Sci. 2016 May; 121(2):155-8.Ups J Med Sci2016-03-21T00:00:002016Dynamic development of the pancreas from birth to adulthood.Authorship 5315935Authorship 53905742001-08-17T00:00:002001-06-25T00:00:00The Mechanisms of matrix Remodeling Around Duct Cells After Partial PancreatectomySummerAuthorship 55598652Assistant Professor1Associate Professor6Fellow or Post Doc0Full Professor3LecturerAuthorship 608252Authorship 824807Authorship 895071127398615Bonner-Weir S, Aguayo-Mazzucato CNaturePhysiology: Pancreatic ß-cell heterogeneity revisited. Nature. 2016 07 21; 535(7612):365-6.Nature2016-07-13T00:00:002016Physiology: Pancreatic ß-cell heterogeneity revisited.Authorship 4931501Authorship 5088687Authorship 5253931Authorship 5281695Authorship 71076Authorship 910195Authorship 962461Authorship 4771482Authorship 4802593Authorship 53989652006-11-30BONNER-WEIR, SUSAN1992-02-01MECHANISM OF ISLET GROWTH AND DIFFERENTIATIONR01DK0445232016-07-31BONNER-WEIR, SUSAN2011-09-20Physiological Factors Driving Maturation of Neonatal Beta CellsR01DK0939092007-07-31HABENER, JOEL F2001-09-30Program Project,Restoration of Endocrine Pancreas Funct*U19DK0612512027-03-31KING, GEORGE L1986-09-30Diabetes Research CenterP30DK0368362010-04-30BONNER-WEIR, SUSAN2009-05-01Zeiss Laser Scan Microscope (LSM) 510-duoS10RR0250652009-04-30BONNER-WEIR, SUSAN2006-05-15Strategies to Identify In Vitro Islet ProgenitorsR01DK0748792010-07-31BONNER-WEIR, SUSAN2005-09-15Phenotypic Analysis of Young and Old Beta CellsR01DK066056Principal InvestigatorPrincipal InvestigatorCo-Principal InvestigatorPrincipal InvestigatorCo-Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorAuthorship 81411Authorship 3652803Authorship 3996895Authorship 4240134Authorship 4336592Authorship 538688Authorship 9371189Authorship 9345266Authorship 9323051027405779Corritore E, Lee YS, Pasquale V, Liberati D, Hsu MJ, Lombard CA, Van Der Smissen P, Vetere A, Bonner-Weir S, Piemonti L, Sokal E, Lysy PAStem cells translational medicineV-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog A Synthetic Modified mRNA Drives Reprogramming of Human Pancreatic Duct-Derived Cells Into Insulin-Secreting Cells. Stem Cells Transl Med. 2016 Nov; 5(11):1525-1537.Stem Cells Transl Med2016-07-12T00:00:002016V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog A Synthetic Modified mRNA Drives Reprogramming of Human Pancreatic Duct-Derived Cells Into Insulin-Secreting Cells.26998407Cavelti-Weder C, Li W, Zumsteg A, Stemann M, Yamada T, Bonner-Weir S, Weir G, Zhou QCurrent pathobiology reportsDirect Reprogramming for Pancreatic Beta-Cells Using Key Developmental Genes. Curr Pathobiol Rep. 2015 Mar 01; 3(1):57-65.Curr Pathobiol Rep2015-01-30T00:00:002015Direct Reprogramming for Pancreatic Beta-Cells Using Key Developmental Genes.27152363Kuznetsova A, Yu Y, Hollister-Lock J, Opare-Addo L, Rozzo A, Sadagurski M, Norquay L, Reed JE, El Khattabi I, Bonner-Weir S, Weir GC, Sharma A, White MFJCI insightTrimeprazine increases IRS2 in human islets and promotes pancreatic ß cell growth and function in mice. JCI Insight. 2016; 1(3).JCI Insight2016-03-17T00:00:002016Trimeprazine increases IRS2 in human islets and promotes pancreatic ß cell growth and function in mice.Authorship 2008362Authorship 263921Authorship 2705004Authorship 2757862Authorship 3631959Authorship 4481502Authorship 4597336Authorship 948843228086099Weir GC, Bonner-Weir SCellGABA Signaling Stimulates ß Cell Regeneration in Diabetic Mice. Cell. 2017 01 12; 168(1-2):7-9.Cell2017-01-12T00:00:002017GABA Signaling Stimulates ß Cell Regeneration in Diabetic Mice.One Joslin PlaceJoslin Diabetes CenterResearch Div., Rm 535One Joslin PlaceBoston02215MAAuthorship 957009228174593Weir GC, Bonner-Weir SFrontiers in geneticsGlucose Driven Changes in Beta Cell Identity Are Important for Function and Possibly Autoimmune Vulnerability during the Progression of Type 1 Diabetes. Front Genet. 2017; 8:2.Front Genet2017-01-24T00:00:002017Glucose Driven Changes in Beta Cell Identity Are Important for Function and Possibly Autoimmune Vulnerability during the Progression of Type 1 Diabetes.8772716Davalli AM, Scaglia L, Zangen DH, Hollister J, Bonner-Weir S, Weir GCDiabetesVulnerability of islets in the immediate posttransplantation period. Dynamic changes in structure and function. Diabetes. 1996 Sep; 45(9):1161-7.Diabetes1996-09-01T00:00:001996Vulnerability of islets in the immediate posttransplantation period. Dynamic changes in structure and function.8869592Davalli AM, Napoli R, Weitgasser R, Capotorto JV, Hirshman MF, Finegood DT, Bonner-Weir S, Horton ES, Weir GCThe Journal of endocrinologyLong-term normalization of GLUT-4 protein content in skeletal muscle of diabetic rats following islet transplantation. J Endocrinol. 1996 Aug; 150(2):255-63.J Endocrinol1996-08-01T00:00:001996Long-term normalization of GLUT-4 protein content in skeletal muscle of diabetic rats following islet transplantation.1397706Chen C, Thorens B, Bonner-Weir S, Weir GC, Leahy JLDiabetesRecovery of glucose-induced insulin secretion in a rat model of NIDDM is not accompanied by return of the B-cell GLUT2 glucose transporter. Diabetes. 1992 Oct; 41(10):1320-7.Diabetes1992-10-01T00:00:001992Recovery of glucose-induced insulin secretion in a rat model of NIDDM is not accompanied by return of the B-cell GLUT2 glucose transporter.12829640Noguchi H, Kaneto H, Weir GC, Bonner-Weir SDiabetesPDX-1 protein containing its own antennapedia-like protein transduction domain can transduce pancreatic duct and islet cells. Diabetes. 2003 Jul; 52(7):1732-7.Diabetes2003-07-01T00:00:002003PDX-1 protein containing its own antennapedia-like protein transduction domain can transduce pancreatic duct and islet cells.12852853Yoon JC, Xu G, Deeney JT, Yang SN, Rhee J, Puigserver P, Levens AR, Yang R, Zhang CY, Lowell BB, Berggren PO, Newgard CB, Bonner-Weir S, Weir G, Spiegelman BMDevelopmental cellSuppression of beta cell energy metabolism and insulin release by PGC-1alpha. Dev Cell. 2003 Jul; 5(1):73-83.Dev Cell2003-07-01T00:00:002003Suppression of beta cell energy metabolism and insulin release by PGC-1alpha.15381202Fernandes JR, Duvivier-Kali VF, Keegan M, Hollister-Lock J, Omer A, Su S, Bonner-Weir S, Feng S, Lee JS, Mulligan RC, Weir GCTransplant immunologyTransplantation of islets transduced with CTLA4-Ig and TGFbeta using adenovirus and lentivirus vectors. Transpl Immunol. 2004 Nov; 13(3):191-200.Transpl Immunol2004-11-01T00:00:002004Transplantation of islets transduced with CTLA4-Ig and TGFbeta using adenovirus and lentivirus vectors.9401638Weir GC, Sharma A, Zangen DH, Bonner-Weir SActa diabetologicaTranscription factor abnormalities as a cause of beta cell dysfunction in diabetes: a hypothesis. Acta Diabetol. 1997 Oct; 34(3):177-84.Acta Diabetol1997-10-01T00:00:001997Transcription factor abnormalities as a cause of beta cell dysfunction in diabetes: a hypothesis.9836521Vasir B, Aiello LP, Yoon KH, Quickel RR, Bonner-Weir S, Weir GCDiabetesHypoxia induces vascular endothelial growth factor gene and protein expression in cultured rat islet cells. Diabetes. 1998 Dec; 47(12):1894-903.Diabetes1998-12-01T00:00:001998Hypoxia induces vascular endothelial growth factor gene and protein expression in cultured rat islet cells.9927499Kopin AS, Mathes WF, McBride EW, Nguyen M, Al-Haider W, Schmitz F, Bonner-Weir S, Kanarek R, Beinborn MThe Journal of clinical investigationThe cholecystokinin-A receptor mediates inhibition of food intake yet is not essential for the maintenance of body weight. J Clin Invest. 1999 Feb; 103(3):383-91.J Clin Invest1999-02-01T00:00:001999The cholecystokinin-A receptor mediates inhibition of food intake yet is not essential for the maintenance of body weight.11782487Laybutt DR, Sharma A, Sgroi DC, Gaudet J, Bonner-Weir S, Weir GCThe Journal of biological chemistryGenetic regulation of metabolic pathways in beta-cells disrupted by hyperglycemia. J Biol Chem. 2002 Mar 29; 277(13):10912-21.J Biol Chem2002-01-08T00:00:002002Genetic regulation of metabolic pathways in beta-cells disrupted by hyperglycemia.11797699Papas KK, Colton CK, Gounarides JS, Roos ES, Jarema MA, Shapiro MJ, Cheng LL, Cline GW, Shulman GI, Wu H, Bonner-Weir S, Weir GCAnnals of the New York Academy of SciencesNMR spectroscopy in beta cell engineering and islet transplantation. Ann N Y Acad Sci. 2001 Nov; 944:96-119.Ann N Y Acad Sci2001-11-01T00:00:002001NMR spectroscopy in beta cell engineering and islet transplantation.12973104Makhlouf L, Duvivier-Kali VF, Bonner-Weir S, Dieperink H, Weir GC, Sayegh MHTransplantationImportance of hyperglycemia on the primary function of allogeneic islet transplants. Transplantation. 2003 Aug 27; 76(4):657-64.Transplantation2003-08-27T00:00:002003Importance of hyperglycemia on the primary function of allogeneic islet transplants.15114073Paty BW, Bonner-Weir S, Laughlin MR, McEwan AJ, Shapiro AMTransplantationToward development of imaging modalities for islets after transplantation: insights from the National Institutes of Health Workshop on Beta Cell Imaging. Transplantation. 2004 Apr 27; 77(8):1133-7.Transplantation2004-04-27T00:00:002004Toward development of imaging modalities for islets after transplantation: insights from the National Institutes of Health Workshop on Beta Cell Imaging.16003374Bonner-Weir S, Weir GCNature biotechnologyNew sources of pancreatic beta-cells. Nat Biotechnol. 2005 Jul; 23(7):857-61.Nat Biotechnol2005-07-01T00:00:002005New sources of pancreatic beta-cells.10905482Stoffers DA, Kieffer TJ, Hussain MA, Drucker DJ, Bonner-Weir S, Habener JF, Egan JMDiabetesInsulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas. Diabetes. 2000 May; 49(5):741-8.Diabetes2000-05-01T00:00:002000Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas.11042468Bonner-Weir STrends in endocrinology and metabolism: TEMLife and death of the pancreatic beta cells. Trends Endocrinol Metab. 2000 Nov; 11(9):375-8.Trends Endocrinol Metab2000-11-01T00:00:002000Life and death of the pancreatic beta cells.Authorship 9672604Authorship 9677176Authorship 9672096Authorship 967208128201207Trivedi N, Hollister-Lock J, Lopez-Avalos MD, O'Neil JJ, Keegan M, Bonner-Weir S, Weir GCEndocrinologyIncrease in ß-Cell Mass in Transplanted Porcine Neonatal Pancreatic Cell Clusters Is Due to Proliferation of ß-Cells and Differentiation of Duct Cells. Endocrinology. 2001 May 01; 142(5):2115-2122.Endocrinology2001-05-01T00:00:002001Increase in ß-Cell Mass in Transplanted Porcine Neonatal Pancreatic Cell Clusters Is Due to Proliferation of ß-Cells and Differentiation of Duct Cells.28252345Ebrahimi A, Jung MH, Dreyfuss JM, Pan H, Sgroi D, Bonner-Weir S, Weir GCIsletsEvidence of stress in ß cells obtained with laser capture microdissection from pancreases of brain dead donors. Islets. 2017 03 04; 9(2):19-29.Islets2017-03-04T00:00:002017Evidence of stress in ß cells obtained with laser capture microdissection from pancreases of brain dead donors.28200925Bonner-Weir SEndocrinologyPerspective: Postnatal Pancreatic ß Cell Growth. Endocrinology. 2000 Jun 01; 141(6):1926-1929.Endocrinology2000-06-01T00:00:002000Perspective: Postnatal Pancreatic ß Cell Growth.28201166Uysal KT, Scheja L, Wiesbrock SM, Bonner-Weir S, Hotamisligil GKEndocrinologyImproved Glucose and Lipid Metabolism in Genetically Obese Mice Lacking aP2. Endocrinology. 2000 Sep 01; 141(9):3388-3396.Endocrinology2000-09-01T00:00:002000Improved Glucose and Lipid Metabolism in Genetically Obese Mice Lacking aP2.10086377Charron MJ, Bonner-Weir SNature medicineImplicating PARP and NAD+ depletion in type I diabetes. Nat Med. 1999 Mar; 5(3):269-70.Nat Med1999-03-01T00:00:001999Implicating PARP and NAD+ depletion in type I diabetes.11574403Moore A, Bonner-Weir S, Weissleder RDiabetesNoninvasive in vivo measurement of beta-cell mass in mouse model of diabetes. Diabetes. 2001 Oct; 50(10):2231-6.Diabetes2001-10-01T00:00:002001Noninvasive in vivo measurement of beta-cell mass in mouse model of diabetes.12011047Kaneto H, Xu G, Fujii N, Kim S, Bonner-Weir S, Weir GCThe Journal of biological chemistryInvolvement of c-Jun N-terminal kinase in oxidative stress-mediated suppression of insulin gene expression. J Biol Chem. 2002 Aug 16; 277(33):30010-8.J Biol Chem2002-05-14T00:00:002002Involvement of c-Jun N-terminal kinase in oxidative stress-mediated suppression of insulin gene expression.20062967Gianani R, Campbell-Thompson M, Sarkar SA, Wasserfall C, Pugliese A, Solis JM, Kent SC, Hering BJ, West E, Steck A, Bonner-Weir S, Atkinson MA, Coppieters K, von Herrath M, Eisenbarth GSDiabetologiaDimorphic histopathology of long-standing childhood-onset diabetes. Diabetologia. 2010 Apr; 53(4):690-8.Diabetologia2010-01-09T00:00:002010Dimorphic histopathology of long-standing childhood-onset diabetes.9345642Corbett J, Serup P, Bonner-Weir S, Nielsen JHDiabetologiaBeta-cell ontogeny: growth and death. Diabetologia. 1997 Oct; 40 Suppl 3:B27-32.Diabetologia1997-10-01T00:00:001997Beta-cell ontogeny: growth and death.9519740Pick A, Clark J, Kubstrup C, Levisetti M, Pugh W, Bonner-Weir S, Polonsky KSDiabetesRole of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat. Diabetes. 1998 Mar; 47(3):358-64.Diabetes1998-03-01T00:00:001998Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat.10828822Bonner-Weir SJournal of molecular endocrinologyIslet growth and development in the adult. J Mol Endocrinol. 2000 Jun; 24(3):297-302.J Mol Endocrinol2000-06-01T00:00:002000Islet growth and development in the adult.1559411Leahy JL, Bonner-Weir S, Weir GCDiabetes careBeta-cell dysfunction induced by chronic hyperglycemia. Current ideas on mechanism of impaired glucose-induced insulin secretion. Diabetes Care. 1992 Mar; 15(3):442-55.Diabetes Care1992-03-01T00:00:001992Beta-cell dysfunction induced by chronic hyperglycemia. Current ideas on mechanism of impaired glucose-induced insulin secretion.11272180Weir GC, Laybutt DR, Kaneto H, Bonner-Weir S, Sharma ADiabetesBeta-cell adaptation and decompensation during the progression of diabetes. Diabetes. 2001 Feb; 50 Suppl 1:S154-9.Diabetes2001-02-01T00:00:002001Beta-cell adaptation and decompensation during the progression of diabetes.1712481Smith FE, Rosen KM, Villa-Komaroff L, Weir GC, Bonner-Weir SProceedings of the National Academy of Sciences of the United States of AmericaEnhanced insulin-like growth factor I gene expression in regenerating rat pancreas. Proc Natl Acad Sci U S A. 1991 Jul 15; 88(14):6152-6.Proc Natl Acad Sci U S A1991-07-15T00:00:001991Enhanced insulin-like growth factor I gene expression in regenerating rat pancreas.Authorship 9753491328380379Aguayo-Mazzucato C, van Haaren M, Mruk M, Lee TB, Crawford C, Hollister-Lock J, Sullivan BA, Johnson JW, Ebrahimi A, Dreyfuss JM, Van Deursen J, Weir GC, Bonner-Weir SCell metabolismß Cell Aging Markers Have Heterogeneous Distribution and Are Induced by Insulin Resistance. Cell Metab. 2017 Apr 04; 25(4):898-910.e5.Cell Metab2017-04-04T00:00:002017ß Cell Aging Markers Have Heterogeneous Distribution and Are Induced by Insulin Resistance.15340475Weir GC, Bonner-Weir SNature biotechnologyBeta-cell precursors--a work in progress. Nat Biotechnol. 2004 Sep; 22(9):1095-6.Nat Biotechnol2004-09-01T00:00:002004Beta-cell precursors--a work in progress.16406191Xu G, Kaneto H, Lopez-Avalos MD, Weir GC, Bonner-Weir SDiabetes research and clinical practiceGLP-1/exendin-4 facilitates beta-cell neogenesis in rat and human pancreatic ducts. Diabetes Res Clin Pract. 2006 Jul; 73(1):107-10.Diabetes Res Clin Pract2006-01-06T00:00:002006GLP-1/exendin-4 facilitates beta-cell neogenesis in rat and human pancreatic ducts.17200709Weir GC, Bonner-Weir SThe Journal of clinical investigationA dominant role for glucose in beta cell compensation of insulin resistance. J Clin Invest. 2007 Jan; 117(1):81-3.J Clin Invest2007-01-01T00:00:002007A dominant role for glucose in beta cell compensation of insulin resistance.9000703Zangen DH, Bonner-Weir S, Lee CH, Latimer JB, Miller CP, Habener JF, Weir GCDiabetesReduced insulin, GLUT2, and IDX-1 in beta-cells after partial pancreatectomy. Diabetes. 1997 Feb; 46(2):258-64.Diabetes1997-02-01T00:00:001997Reduced insulin, GLUT2, and IDX-1 in beta-cells after partial pancreatectomy.12502499Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PCDiabetesBeta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes. 2003 Jan; 52(1):102-10.Diabetes2003-01-01T00:00:002003Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes.1466031Montaña E, Bonner-Weir S, Weir GCTransplantation proceedingsBeta-cell mass falls progressively when hyperglycemia persists after islet transplantation. Transplant Proc. 1992 Dec; 24(6):2996.Transplant Proc1992-12-01T00:00:001992Beta-cell mass falls progressively when hyperglycemia persists after islet transplantation.11349728Vasir B, Jonas JC, Steil GM, Hollister-Lock J, Hasenkamp W, Sharma A, Bonner-Weir S, Weir GCTransplantationGene expression of VEGF and its receptors Flk-1/KDR and Flt-1 in cultured and transplanted rat islets. Transplantation. 2001 Apr 15; 71(7):924-35.Transplantation2001-04-15T00:00:002001Gene expression of VEGF and its receptors Flk-1/KDR and Flt-1 in cultured and transplanted rat islets.11812749Laybutt DR, Kaneto H, Hasenkamp W, Grey S, Jonas JC, Sgroi DC, Groff A, Ferran C, Bonner-Weir S, Sharma A, Weir GCDiabetesIncreased expression of antioxidant and antiapoptotic genes in islets that may contribute to beta-cell survival during chronic hyperglycemia. Diabetes. 2002 Feb; 51(2):413-23.Diabetes2002-02-01T00:00:002002Increased expression of antioxidant and antiapoptotic genes in islets that may contribute to beta-cell survival during chronic hyperglycemia.9193561Trivedi N, Suzuki K, Bonner-Weir S, Hollister-Lock J, Weir GCTransplantation proceedingsIslet number in an immunobarrier device required to treat diabetes in mice. Transplant Proc. 1997 Jun; 29(4):2142-3.Transplant Proc1997-06-01T00:00:001997Islet number in an immunobarrier device required to treat diabetes in mice.12438314Laybutt DR, Glandt M, Xu G, Ahn YB, Trivedi N, Bonner-Weir S, Weir GCThe Journal of biological chemistryCritical reduction in beta-cell mass results in two distinct outcomes over time. Adaptation with impaired glucose tolerance or decompensated diabetes. J Biol Chem. 2003 Jan 31; 278(5):2997-3005.J Biol Chem2002-11-15T00:00:002002Critical reduction in beta-cell mass results in two distinct outcomes over time. Adaptation with impaired glucose tolerance or decompensated diabetes.12630945Tatarkiewicz K, López-Avalos MD, Yoon KH, Trivedi N, Quickel RR, Bonner-Weir S, Weir GCDevelopment, growth & differentiationDevelopment and retroviral transduction of porcine neonatal pancreatic islet cells in monolayer culture. Dev Growth Differ. 2003 Feb; 45(1):39-50.Dev Growth Differ2003-02-01T00:00:002003Development and retroviral transduction of porcine neonatal pancreatic islet cells in monolayer culture.10096520Tatarkiewicz K, Hollister-Lock J, Quickel RR, Colton CK, Bonner-Weir S, Weir GCTransplantationReversal of hyperglycemia in mice after subcutaneous transplantation of macroencapsulated islets. Transplantation. 1999 Mar 15; 67(5):665-71.Transplantation1999-03-15T00:00:001999Reversal of hyperglycemia in mice after subcutaneous transplantation of macroencapsulated islets.11158595Dutta S, Gannon M, Peers B, Wright C, Bonner-Weir S, Montminy MProceedings of the National Academy of Sciences of the United States of AmericaPDX:PBX complexes are required for normal proliferation of pancreatic cells during development. Proc Natl Acad Sci U S A. 2001 Jan 30; 98(3):1065-70.Proc Natl Acad Sci U S A2001-01-16T00:00:002001PDX:PBX complexes are required for normal proliferation of pancreatic cells during development.12031967Laybutt DR, Weir GC, Kaneto H, Lebet J, Palmiter RD, Sharma A, Bonner-Weir SDiabetesOverexpression of c-Myc in beta-cells of transgenic mice causes proliferation and apoptosis, downregulation of insulin gene expression, and diabetes. Diabetes. 2002 Jun; 51(6):1793-804.Diabetes2002-06-01T00:00:002002Overexpression of c-Myc in beta-cells of transgenic mice causes proliferation and apoptosis, downregulation of insulin gene expression, and diabetes.17473224Yatoh S, Dodge R, Akashi T, Omer A, Sharma A, Weir GC, Bonner-Weir SDiabetesDifferentiation of affinity-purified human pancreatic duct cells to beta-cells. Diabetes. 2007 Jul; 56(7):1802-9.Diabetes2007-05-01T00:00:002007Differentiation of affinity-purified human pancreatic duct cells to beta-cells.11316779Trivedi N, Hollister-Lock J, Lopez-Avalos MD, O'Neil JJ, Keegan M, Bonner-Weir S, Weir GCEndocrinologyIncrease in beta-cell mass in transplanted porcine neonatal pancreatic cell clusters is due to proliferation of beta-cells and differentiation of duct cells. Endocrinology. 2001 May; 142(5):2115-22.Endocrinology2001-05-01T00:00:002001Increase in beta-cell mass in transplanted porcine neonatal pancreatic cell clusters is due to proliferation of beta-cells and differentiation of duct cells.12727989Yoon KH, Ko SH, Cho JH, Lee JM, Ahn YB, Song KH, Yoo SJ, Kang MI, Cha BY, Lee KW, Son HY, Kang SK, Kim HS, Lee IK, Bonner-Weir SThe Journal of clinical endocrinology and metabolismSelective beta-cell loss and alpha-cell expansion in patients with type 2 diabetes mellitus in Korea. J Clin Endocrinol Metab. 2003 May; 88(5):2300-8.J Clin Endocrinol Metab2003-05-01T00:00:002003Selective beta-cell loss and alpha-cell expansion in patients with type 2 diabetes mellitus in Korea.14671389Bonner-Weir SHormone researchStem cells in diabetes: what has been achieved. Horm Res. 2003; 60 Suppl 3:10.Horm Res2003-01-01T00:00:002003Stem cells in diabetes: what has been achieved.15561905Weir GC, Bonner-Weir SDiabetesFive stages of evolving beta-cell dysfunction during progression to diabetes. Diabetes. 2004 Dec; 53 Suppl 3:S16-21.Diabetes2004-12-01T00:00:002004Five stages of evolving beta-cell dysfunction during progression to diabetes.8951219Suzuki K, Bonner-Weir S, Hollister J, Weir GCCell transplantationA method for estimating number and mass of islets transplanted within a membrane device. Cell Transplant. 1996 Nov-Dec; 5(6):613-25.Cell Transplant1996-11-01T00:00:001996A method for estimating number and mass of islets transplanted within a membrane device.9075738Scaglia L, Cahill CJ, Finegood DT, Bonner-Weir SEndocrinologyApoptosis participates in the remodeling of the endocrine pancreas in the neonatal rat. Endocrinology. 1997 Apr; 138(4):1736-41.Endocrinology1997-04-01T00:00:001997Apoptosis participates in the remodeling of the endocrine pancreas in the neonatal rat.9489762Suzuki K, Bonner-Weir S, Hollister-Lock J, Colton CK, Weir GCCell transplantationNumber and volume of islets transplanted in immunobarrier devices. Cell Transplant. 1998 Jan-Feb; 7(1):47-52.Cell Transplant1998-01-01T00:00:001998Number and volume of islets transplanted in immunobarrier devices.9532136Tatarkiewicz K, Hollister-Lock J, Quickel RR, Cotton CK, Bonner-Weir S, Weir GCTransplantation proceedingsSubcutaneous transplantation of rat islets into diabetic nude. Transplant Proc. 1998 Mar; 30(2):479-80.Transplant Proc1998-03-01T00:00:001998Subcutaneous transplantation of rat islets into diabetic nude.10784073Trivedi N, Steil GM, Colton CK, Bonner-Weir S, Weir GCCell transplantationImproved vascularization of planar membrane diffusion devices following continuous infusion of vascular endothelial growth factor. Cell Transplant. 2000 Jan-Feb; 9(1):115-24.Cell Transplant2000-01-01T00:00:002000Improved vascularization of planar membrane diffusion devices following continuous infusion of vascular endothelial growth factor.11287362Steil GM, Trivedi N, Jonas JC, Hasenkamp WM, Sharma A, Bonner-Weir S, Weir GCAmerican journal of physiology. Endocrinology and metabolismAdaptation of beta-cell mass to substrate oversupply: enhanced function with normal gene expression. Am J Physiol Endocrinol Metab. 2001 May; 280(5):E788-96.Am J Physiol Endocrinol Metab2001-05-01T00:00:002001Adaptation of beta-cell mass to substrate oversupply: enhanced function with normal gene expression.9231647Weir GC, Bonner-Weir SDiabetesScientific and political impediments to successful islet transplantation. Diabetes. 1997 Aug; 46(8):1247-56.Diabetes1997-08-01T00:00:001997Scientific and political impediments to successful islet transplantation.9560151Dutta S, Bonner-Weir S, Montminy M, Wright CNatureRegulatory factor linked to late-onset diabetes? Nature. 1998 Apr 09; 392(6676):560.Nature1998-04-09T00:00:001998Regulatory factor linked to late-onset diabetes?18682384Larade K, Jiang Z, Zhang Y, Wang W, Bonner-Weir S, Zhu H, Bunn HFThe Journal of biological chemistryLoss of Ncb5or results in impaired fatty acid desaturation, lipoatrophy, and diabetes. J Biol Chem. 2008 Oct 24; 283(43):29285-91.J Biol Chem2008-08-05T00:00:002008Loss of Ncb5or results in impaired fatty acid desaturation, lipoatrophy, and diabetes.2424696Weir GC, Leahy JL, Bonner-Weir SDiabetes/metabolism reviewsExperimental reduction of B-cell mass: implications for the pathogenesis of diabetes. Diabetes Metab Rev. 1986; 2(1-2):125-61.Diabetes Metab Rev1986-01-01T00:00:001986Experimental reduction of B-cell mass: implications for the pathogenesis of diabetes.1551494Gianani R, Pugliese A, Bonner-Weir S, Shiffrin AJ, Soeldner JS, Erlich H, Awdeh Z, Alper CA, Jackson RA, Eisenbarth GSDiabetesPrognostically significant heterogeneity of cytoplasmic islet cell antibodies in relatives of patients with type I diabetes. Diabetes. 1992 Mar; 41(3):347-53.Diabetes1992-03-01T00:00:001992Prognostically significant heterogeneity of cytoplasmic islet cell antibodies in relatives of patients with type I diabetes.11213060Trivedi N, Keegan M, Steil GM, Hollister-Lock J, Hasenkamp WM, Colton CK, Bonner-Weir S, Weir GCTransplantationIslets in alginate macrobeads reverse diabetes despite minimal acute insulin secretory responses. Transplantation. 2001 Jan 27; 71(2):203-11.Transplantation2001-01-27T00:00:002001Islets in alginate macrobeads reverse diabetes despite minimal acute insulin secretory responses.20051380Aye T, Toschi E, Sharma A, Sgroi D, Bonner-Weir SThe journal of histochemistry and cytochemistry : official journal of the Histochemistry SocietyIdentification of markers for newly formed beta-cells in the perinatal period: a time of recognized beta-cell immaturity. J Histochem Cytochem. 2010 Apr; 58(4):369-76.J Histochem Cytochem2010-01-04T00:00:002010Identification of markers for newly formed beta-cells in the perinatal period: a time of recognized beta-cell immaturity.11374418Lopez-Avalos MD, Tatarkiewicz K, Sharma A, Bonner-Weir S, Weir GCTransplantationEnhanced maturation of porcine neonatal pancreatic cell clusters with growth factors fails to improve transplantation outcome. Transplantation. 2001 Apr 27; 71(8):1154-62.Transplantation2001-04-27T00:00:002001Enhanced maturation of porcine neonatal pancreatic cell clusters with growth factors fails to improve transplantation outcome.21088282Thorrez L, Laudadio I, Van Deun K, Quintens R, Hendrickx N, Granvik M, Lemaire K, Schraenen A, Van Lommel L, Lehnert S, Aguayo-Mazzucato C, Cheng-Xue R, Gilon P, Van Mechelen I, Bonner-Weir S, Lemaigre F, Schuit FGenome researchTissue-specific disallowance of housekeeping genes: the other face of cell differentiation. Genome Res. 2011 Jan; 21(1):95-105.Genome Res2010-11-18T00:00:002010Tissue-specific disallowance of housekeeping genes: the other face of cell differentiation.15028943Ko SH, Suh SH, Kim BJ, Ahn YB, Song KH, Yoo SJ, Son HS, Cha BY, Lee KW, Son HY, Kang SK, Bonner-Weir S, Weir GC, Yoon KH, Park CGPancreasExpression of the intermediate filament vimentin in proliferating duct cells as a marker of pancreatic precursor cells. Pancreas. 2004 Mar; 28(2):121-8.Pancreas2004-03-01T00:00:002004Expression of the intermediate filament vimentin in proliferating duct cells as a marker of pancreatic precursor cells.1969425Weir GC, Bonner-Weir SThe Journal of clinical investigationIslets of Langerhans: the puzzle of intraislet interactions and their relevance to diabetes. J Clin Invest. 1990 Apr; 85(4):983-7.J Clin Invest1990-04-01T00:00:001990Islets of Langerhans: the puzzle of intraislet interactions and their relevance to diabetes.9593777Pontoglio M, Sreenan S, Roe M, Pugh W, Ostrega D, Doyen A, Pick AJ, Baldwin A, Velho G, Froguel P, Levisetti M, Bonner-Weir S, Bell GI, Yaniv M, Polonsky KSThe Journal of clinical investigationDefective insulin secretion in hepatocyte nuclear factor 1alpha-deficient mice. J Clin Invest. 1998 May 15; 101(10):2215-22.J Clin Invest1998-05-15T00:00:001998Defective insulin secretion in hepatocyte nuclear factor 1alpha-deficient mice.10415561Wu H, Avgoustiniatos ES, Swette L, Bonner-Weir S, Weir GC, Colton CKAnnals of the New York Academy of SciencesIn situ electrochemical oxygen generation with an immunoisolation device. Ann N Y Acad Sci. 1999 Jun 18; 875:105-25.Ann N Y Acad Sci1999-06-18T00:00:001999In situ electrochemical oxygen generation with an immunoisolation device.18199433Nishimura W, Rowan S, Salameh T, Maas RL, Bonner-Weir S, Sell SM, Sharma ADevelopmental biologyPreferential reduction of beta cells derived from Pax6-MafB pathway in MafB deficient mice. Dev Biol. 2008 Feb 15; 314(2):443-56.Dev Biol2007-12-23T00:00:002007Preferential reduction of beta cells derived from Pax6-MafB pathway in MafB deficient mice.9580368Montaña E, Bonner-Weir S, Weir GCAdvances in experimental medicine and biologyBeta cell replication and mass in islet transplantation. Adv Exp Med Biol. 1997; 426:421-7.Adv Exp Med Biol1997-01-01T00:00:001997Beta cell replication and mass in islet transplantation.10700217Sachs DH, Bonner-Weir SNature medicineNew islets from old. Nat Med. 2000 Mar; 6(3):250-1.Nat Med2000-03-01T00:00:002000New islets from old.2408948Leahy JL, Bonner-Weir S, Weir GCDiabetesAbnormal insulin secretion in a streptozocin model of diabetes. Effects of insulin treatment. Diabetes. 1985 Jul; 34(7):660-6.Diabetes1985-07-01T00:00:001985Abnormal insulin secretion in a streptozocin model of diabetes. Effects of insulin treatment.19168505Nagaya M, Katsuta H, Kaneto H, Bonner-Weir S, Weir GCThe Journal of endocrinologyAdult mouse intrahepatic biliary epithelial cells induced in vitro to become insulin-producing cells. J Endocrinol. 2009 Apr; 201(1):37-47.J Endocrinol2009-01-23T00:00:002009Adult mouse intrahepatic biliary epithelial cells induced in vitro to become insulin-producing cells.19183938Kikugawa R, Katsuta H, Akashi T, Yatoh S, Weir GC, Sharma A, Bonner-Weir SDiabetologiaDifferentiation of COPAS-sorted non-endocrine pancreatic cells into insulin-positive cells in the mouse. Diabetologia. 2009 Apr; 52(4):645-52.Diabetologia2009-01-30T00:00:002009Differentiation of COPAS-sorted non-endocrine pancreatic cells into insulin-positive cells in the mouse.20644627Marselli L, Thorne J, Dahiya S, Sgroi DC, Sharma A, Bonner-Weir S, Marchetti P, Weir GCPloS oneGene expression profiles of Beta-cell enriched tissue obtained by laser capture microdissection from subjects with type 2 diabetes. PLoS One. 2010 Jul 13; 5(7):e11499.PLoS One2010-07-13T00:00:002010Gene expression profiles of Beta-cell enriched tissue obtained by laser capture microdissection from subjects with type 2 diabetes.20719077Hamamoto Y, Akashi T, Inada A, Bonner-Weir S, Weir GCCell transplantationLack of evidence for recipient precursor cells replenishing ß-cells in transplanted islets. Cell Transplant. 2010; 19(12):1563-72.Cell Transplant2010-08-17T00:00:002010Lack of evidence for recipient precursor cells replenishing ß-cells in transplanted islets.15896300Noguchi H, Matsushita M, Matsumoto S, Lu YF, Matsui H, Bonner-Weir SBiochemical and biophysical research communicationsMechanism of PDX-1 protein transduction. Biochem Biophys Res Commun. 2005 Jun 24; 332(1):68-74.Biochem Biophys Res Commun2005-06-24T00:00:002005Mechanism of PDX-1 protein transduction.6114005Weir GC, Clore ET, Zmachinski CJ, Bonner-Weir SDiabetesIslet secretion in a new experimental model for non-insulin-dependent diabetes. Diabetes. 1981 Jul; 30(7):590-5.Diabetes1981-07-01T00:00:001981Islet secretion in a new experimental model for non-insulin-dependent diabetes.8603757Brunicardi FC, Stagner J, Bonner-Weir S, Wayland H, Kleinman R, Livingston E, Guth P, Menger M, McCuskey R, Intaglietta M, Charles A, Ashley S, Cheung A, Ipp E, Gilman S, Howard T, Passaro EDiabetesMicrocirculation of the islets of Langerhans. Long Beach Veterans Administration Regional Medical Education Center Symposium. Diabetes. 1996 Apr; 45(4):385-92.Diabetes1996-04-01T00:00:001996Microcirculation of the islets of Langerhans. Long Beach Veterans Administration Regional Medical Education Center Symposium.8622964Verchere CB, D'Alessio DA, Palmiter RD, Weir GC, Bonner-Weir S, Baskin DG, Kahn SEProceedings of the National Academy of Sciences of the United States of AmericaIslet amyloid formation associated with hyperglycemia in transgenic mice with pancreatic beta cell expression of human islet amyloid polypeptide. Proc Natl Acad Sci U S A. 1996 Apr 16; 93(8):3492-6.Proc Natl Acad Sci U S A1996-04-16T00:00:001996Islet amyloid formation associated with hyperglycemia in transgenic mice with pancreatic beta cell expression of human islet amyloid polypeptide.17545163Xue B, Kim YB, Lee A, Toschi E, Bonner-Weir S, Kahn CR, Neel BG, Kahn BBThe Journal of biological chemistryProtein-tyrosine phosphatase 1B deficiency reduces insulin resistance and the diabetic phenotype in mice with polygenic insulin resistance. J Biol Chem. 2007 Aug 17; 282(33):23829-40.J Biol Chem2007-06-01T00:00:002007Protein-tyrosine phosphatase 1B deficiency reduces insulin resistance and the diabetic phenotype in mice with polygenic insulin resistance.19882138Vetere A, Li WC, Paroni F, Juhl K, Guo L, Nishimura W, Dai X, Bonner-Weir S, Sharma ADiabetologiaOVO homologue-like 1 (Ovol1) transcription factor: a novel target of neurogenin-3 in rodent pancreas. Diabetologia. 2010 Jan; 53(1):115-22.Diabetologia2009-10-31T00:00:002009OVO homologue-like 1 (Ovol1) transcription factor: a novel target of neurogenin-3 in rodent pancreas.6337906Halban PA, Bonner-Weir S, Weir GCDiabetesElevated proinsulin biosynthesis in vitro from a rat model of non-insulin-dependent diabetes mellitus. Diabetes. 1983 Mar; 32(3):277-83.Diabetes1983-03-01T00:00:001983Elevated proinsulin biosynthesis in vitro from a rat model of non-insulin-dependent diabetes mellitus.7813803Davalli AM, Ogawa Y, Scaglia L, Wu YJ, Hollister J, Bonner-Weir S, Weir GCDiabetesFunction, mass, and replication of porcine and rat islets transplanted into diabetic nude mice. Diabetes. 1995 Jan; 44(1):104-11.Diabetes1995-01-01T00:00:001995Function, mass, and replication of porcine and rat islets transplanted into diabetic nude mice.8539932Davalli AM, Scaglia L, Zangen DH, Hollister J, Bonner-Weir S, Weir GCTransplantation proceedingsEarly changes in syngeneic islet grafts: effect of recipient's metabolic control on graft outcome. Transplant Proc. 1995 Dec; 27(6):3238-9.Transplant Proc1995-12-01T00:00:001995Early changes in syngeneic islet grafts: effect of recipient's metabolic control on graft outcome.16586439Inada A, Nienaber C, Fonseca S, Bonner-Weir SDevelopmental dynamics : an official publication of the American Association of AnatomistsTiming and expression pattern of carbonic anhydrase II in pancreas. Dev Dyn. 2006 Jun; 235(6):1571-7.Dev Dyn2006-06-01T00:00:002006Timing and expression pattern of carbonic anhydrase II in pancreas.9082744Weitgasser R, Davalli AM, Capotorto JV, Finegood DT, Bonner-Weir S, Weir GCActa medica AustriacaIslet transplantation in diabetic Lewis rats--a comparison of the transplantation sites kidney and spleen capsule. Acta Med Austriaca. 1996; 23(5):156-9.Acta Med Austriaca1996-01-01T00:00:001996Islet transplantation in diabetic Lewis rats--a comparison of the transplantation sites kidney and spleen capsule.19576197Nishimura W, Bonner-Weir S, Sharma ADevelopmental biologyExpression of MafA in pancreatic progenitors is detrimental for pancreatic development. Dev Biol. 2009 Sep 01; 333(1):108-20.Dev Biol2009-07-01T00:00:002009Expression of MafA in pancreatic progenitors is detrimental for pancreatic development.19667185Borowiec M, Liew CW, Thompson R, Boonyasrisawat W, Hu J, Mlynarski WM, El Khattabi I, Kim SH, Marselli L, Rich SS, Krolewski AS, Bonner-Weir S, Sharma A, Sale M, Mychaleckyj JC, Kulkarni RN, Doria AProceedings of the National Academy of Sciences of the United States of AmericaMutations at the BLK locus linked to maturity onset diabetes of the young and beta-cell dysfunction. Proc Natl Acad Sci U S A. 2009 Aug 25; 106(34):14460-5.Proc Natl Acad Sci U S A2009-08-10T00:00:002009Mutations at the BLK locus linked to maturity onset diabetes of the young and beta-cell dysfunction.21190012Aguayo-Mazzucato C, Koh A, El Khattabi I, Li WC, Toschi E, Jermendy A, Juhl K, Mao K, Weir GC, Sharma A, Bonner-Weir SDiabetologiaMafa expression enhances glucose-responsive insulin secretion in neonatal rat beta cells. Diabetologia. 2011 Mar; 54(3):583-93.Diabetologia2010-12-29T00:00:002010Mafa expression enhances glucose-responsive insulin secretion in neonatal rat beta cells.22919061Katsuta H, Aguayo-Mazzucato C, Katsuta R, Akashi T, Hollister-Lock J, Sharma AJ, Bonner-Weir S, Weir GCEndocrinologySubpopulations of GFP-marked mouse pancreatic ß-cells differ in size, granularity, and insulin secretion. Endocrinology. 2012 Nov; 153(11):5180-7.Endocrinology2012-08-23T00:00:002012Subpopulations of GFP-marked mouse pancreatic ß-cells differ in size, granularity, and insulin secretion.20039374Powers DE, Millman JR, Bonner-Weir S, Rappel MJ, Colton CKBiotechnology progressAccurate control of oxygen level in cells during culture on silicone rubber membranes with application to stem cell differentiation. Biotechnol Prog. 2010 May-Jun; 26(3):805-18.Biotechnol Prog2010-05-01T00:00:002010Accurate control of oxygen level in cells during culture on silicone rubber membranes with application to stem cell differentiation.20570953Weir GC, Bonner-Weir SEndocrinologyDreams for type 1 diabetes: shutting off autoimmunity and stimulating beta-cell regeneration. Endocrinology. 2010 Jul; 151(7):2971-3.Endocrinology2010-07-01T00:00:002010Dreams for type 1 diabetes: shutting off autoimmunity and stimulating beta-cell regeneration.20585452Kennedy J, Katsuta H, Jung MH, Marselli L, Goldfine AB, Balis UJ, Sgroi D, Bonner-Weir S, Weir GCPloS oneProtective unfolded protein response in human pancreatic beta cells transplanted into mice. PLoS One. 2010 Jun 18; 5(6):e11211.PLoS One2010-06-18T00:00:002010Protective unfolded protein response in human pancreatic beta cells transplanted into mice.20663919Li WC, Rukstalis JM, Nishimura W, Tchipashvili V, Habener JF, Sharma A, Bonner-Weir SJournal of cell scienceActivation of pancreatic-duct-derived progenitor cells during pancreas regeneration in adult rats. J Cell Sci. 2010 Aug 15; 123(Pt 16):2792-802.J Cell Sci2010-07-27T00:00:002010Activation of pancreatic-duct-derived progenitor cells during pancreas regeneration in adult rats.21067465Johnson AS, O'Sullivan E, D'Aoust LN, Omer A, Bonner-Weir S, Fisher RJ, Weir GC, Colton CKTissue engineering. Part C, MethodsQuantitative assessment of islets of Langerhans encapsulated in alginate. Tissue Eng Part C Methods. 2011 Apr; 17(4):435-49.Tissue Eng Part C Methods2011-01-16T00:00:002011Quantitative assessment of islets of Langerhans encapsulated in alginate.2021-03-31BONNER-WEIR, SUSAN2017-04-01Aging of the beta cell and type 2 diabetesR01DK110390Principal Investigator3882490Giddings SJ, Orland MJ, Weir GC, Bonner-Weir S, Permutt MADiabetesImpaired insulin biosynthetic capacity in a rat model for non-insulin-dependent diabetes. Studies with dexamethasone. Diabetes. 1985 Mar; 34(3):235-40.Diabetes1985-03-01T00:00:001985Impaired insulin biosynthetic capacity in a rat model for non-insulin-dependent diabetes. Studies with dexamethasone.10701496Yoon KH, Quickel RR, Tatarkiewicz K, Ulrich TR, Hollister-Lock J, Trivedi N, Bonner-Weir S, Weir GCCell transplantationDifferentiation and expansion of beta cell mass in porcine neonatal pancreatic cell clusters transplanted into nude mice. Cell Transplant. 1999 Nov-Dec; 8(6):673-89.Cell Transplant1999-11-01T00:00:001999Differentiation and expansion of beta cell mass in porcine neonatal pancreatic cell clusters transplanted into nude mice.Authorship 1010646228889951Aguayo-Mazzucato C, Bonner-Weir SCell metabolismPancreatic ß Cell Regeneration as a Possible Therapy for Diabetes. Cell Metab. 2018 01 09; 27(1):57-67.Cell Metab2017-09-07T00:00:002017Pancreatic ß Cell Regeneration as a Possible Therapy for Diabetes.11799123Kaneto H, Sharma A, Suzuma K, Laybutt DR, Xu G, Bonner-Weir S, Weir GCThe Journal of biological chemistryInduction of c-Myc expression suppresses insulin gene transcription by inhibiting NeuroD/BETA2-mediated transcriptional activation. J Biol Chem. 2002 Apr 12; 277(15):12998-3006.J Biol Chem2002-01-17T00:00:002002Induction of c-Myc expression suppresses insulin gene transcription by inhibiting NeuroD/BETA2-mediated transcriptional activation.15919800Medarova Z, Bonner-Weir S, Lipes M, Moore ADiabetesImaging beta-cell death with a near-infrared probe. Diabetes. 2005 Jun; 54(6):1780-8.Diabetes2005-06-01T00:00:002005Imaging beta-cell death with a near-infrared probe.16195867Patti ME, McMahon G, Mun EC, Bitton A, Holst JJ, Goldsmith J, Hanto DW, Callery M, Arky R, Nose V, Bonner-Weir S, Goldfine ABDiabetologiaSevere hypoglycaemia post-gastric bypass requiring partial pancreatectomy: evidence for inappropriate insulin secretion and pancreatic islet hyperplasia. Diabetologia. 2005 Nov; 48(11):2236-40.Diabetologia2005-09-30T00:00:002005Severe hypoglycaemia post-gastric bypass requiring partial pancreatectomy: evidence for inappropriate insulin secretion and pancreatic islet hyperplasia.16921545Yatoh S, Akashi T, Chan PP, Kaneto H, Sharma A, Bonner-Weir S, Weir GCDiabetes/metabolism research and reviewsNeuroD and reaggregation induce beta-cell specific gene expression in cultured hepatocytes. Diabetes Metab Res Rev. 2007 Mar; 23(3):239-49.Diabetes Metab Res Rev2007-03-01T00:00:002007NeuroD and reaggregation induce beta-cell specific gene expression in cultured hepatocytes.16957737Krishnamurthy J, Ramsey MR, Ligon KL, Torrice C, Koh A, Bonner-Weir S, Sharpless NENaturep16INK4a induces an age-dependent decline in islet regenerative potential. Nature. 2006 Sep 28; 443(7110):453-7.Nature2006-09-06T00:00:002006p16INK4a induces an age-dependent decline in islet regenerative potential.17180350Ahn YB, Xu G, Marselli L, Toschi E, Sharma A, Bonner-Weir S, Sgroi DC, Weir GCDiabetologiaChanges in gene expression in beta cells after islet isolation and transplantation using laser-capture microdissection. Diabetologia. 2007 Feb; 50(2):334-42.Diabetologia2006-12-16T00:00:002006Changes in gene expression in beta cells after islet isolation and transplantation using laser-capture microdissection.18359095de Koning EJ, Bonner-Weir S, Rabelink TJTrends in pharmacological sciencesPreservation of beta-cell function by targeting beta-cell mass. Trends Pharmacol Sci. 2008 Apr; 29(4):218-27.Trends Pharmacol Sci2008-03-21T00:00:002008Preservation of beta-cell function by targeting beta-cell mass.2869846Samols E, Bonner-Weir S, Weir GCClinics in endocrinology and metabolismIntra-islet insulin-glucagon-somatostatin relationships. Clin Endocrinol Metab. 1986 Feb; 15(1):33-58.Clin Endocrinol Metab1986-02-01T00:00:001986Intra-islet insulin-glucagon-somatostatin relationships.9532194Yoon KH, Quickel RR, Tatarkiewicz K, Weir GC, Bonner-Weir STransplantation proceedingsGrowth and differentiation of transplanted porcine neonatal pancreatic cell clusters in normal nude mice. Transplant Proc. 1998 Mar; 30(2):601.Transplant Proc1998-03-01T00:00:001998Growth and differentiation of transplanted porcine neonatal pancreatic cell clusters in normal nude mice.23363033Weir GC, Bonner-Weir SAnnals of the New York Academy of SciencesIslet ß cell mass in diabetes and how it relates to function, birth, and death. Ann N Y Acad Sci. 2013 Apr; 1281:92-105.Ann N Y Acad Sci2013-01-30T00:00:002013Islet ß cell mass in diabetes and how it relates to function, birth, and death.8150225Horio F, Fukuda M, Katoh H, Petruzzelli M, Yano N, Rittershaus C, Bonner-Weir S, Hattori MDiabetologiaReactive oxygen intermediates in autoimmune islet cell destruction of the NOD mouse induced by peritoneal exudate cells (rich in macrophages) but not T cells. Diabetologia. 1994 Jan; 37(1):22-31.Diabetologia1994-01-01T00:00:001994Reactive oxygen intermediates in autoimmune islet cell destruction of the NOD mouse induced by peritoneal exudate cells (rich in macrophages) but not T cells.11272186Laybutt R, Hasenkamp W, Groff A, Grey S, Jonas JC, Kaneto H, Sharma A, Bonner-Weir S, Weir GDiabetesbeta-cell adaptation to hyperglycemia. Diabetes. 2001 Feb; 50 Suppl 1:S180-1.Diabetes2001-02-01T00:00:002001beta-cell adaptation to hyperglycemia.11272192Bonner-Weir SDiabetesbeta-cell turnover: its assessment and implications. Diabetes. 2001 Feb; 50 Suppl 1:S20-4.Diabetes2001-02-01T00:00:002001beta-cell turnover: its assessment and implications.16932290Bonner-Weir S, Sharma ANature clinical practice. Endocrinology & metabolismAre there pancreatic progenitor cells from which new islets form after birth? Nat Clin Pract Endocrinol Metab. 2006 May; 2(5):240-1.Nat Clin Pract Endocrinol Metab2006-05-01T00:00:002006Are there pancreatic progenitor cells from which new islets form after birth?16936189Evgenov NV, Medarova Z, Pratt J, Pantazopoulos P, Leyting S, Bonner-Weir S, Moore ADiabetesIn vivo imaging of immune rejection in transplanted pancreatic islets. Diabetes. 2006 Sep; 55(9):2419-28.Diabetes2006-09-01T00:00:002006In vivo imaging of immune rejection in transplanted pancreatic islets.16542618Inada A, Bonner-Weir S, Toschi ECurrent diabetes reportsHow can we get more beta cells? Curr Diab Rep. 2006 Apr; 6(2):96-101.Curr Diab Rep2006-04-01T00:00:002006How can we get more beta cells?16580660Nishimura W, Kondo T, Salameh T, El Khattabi I, Dodge R, Bonner-Weir S, Sharma ADevelopmental biologyA switch from MafB to MafA expression accompanies differentiation to pancreatic beta-cells. Dev Biol. 2006 May 15; 293(2):526-39.Dev Biol2006-04-03T00:00:002006A switch from MafB to MafA expression accompanies differentiation to pancreatic beta-cells.20697375Pisania A, Papas KK, Powers DE, Rappel MJ, Omer A, Bonner-Weir S, Weir GC, Colton CKLaboratory investigation; a journal of technical methods and pathologyEnumeration of islets by nuclei counting and light microscopic analysis. Lab Invest. 2010 Nov; 90(11):1676-86.Lab Invest2010-08-09T00:00:002010Enumeration of islets by nuclei counting and light microscopic analysis.2863944Weir GC, Bonner-Weir SAdvances in experimental medicine and biologyPancreatic somatostatin. Adv Exp Med Biol. 1985; 188:403-23.Adv Exp Med Biol1985-01-01T00:00:001985Pancreatic somatostatin.21951399Weir GC, Cavelti-Weder C, Bonner-Weir SGenome medicineStem cell approaches for diabetes: towards beta cell replacement. Genome Med. 2011 Sep 27; 3(9):61.Genome Med2011-09-27T00:00:002011Stem cell approaches for diabetes: towards beta cell replacement.16541278Inada A, Nienaber C, Bonner-Weir SDiabetologiaEndogenous beta-galactosidase expression in murine pancreatic islets. Diabetologia. 2006 May; 49(5):1120-2.Diabetologia2006-03-16T00:00:002006Endogenous beta-galactosidase expression in murine pancreatic islets.2108068Weir GC, Bonner-Weir S, Leahy JLDiabetesIslet mass and function in diabetes and transplantation. Diabetes. 1990 Apr; 39(4):401-5.Diabetes1990-04-01T00:00:001990Islet mass and function in diabetes and transplantation.17360984Xu G, Kaneto H, Laybutt DR, Duvivier-Kali VF, Trivedi N, Suzuma K, King GL, Weir GC, Bonner-Weir SDiabetesDownregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in diabetes. Diabetes. 2007 Jun; 56(6):1551-8.Diabetes2007-03-14T00:00:002007Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in diabetes.17406265Medarova Z, Evgenov NV, Dai G, Bonner-Weir S, Moore ANature protocolsIn vivo multimodal imaging of transplanted pancreatic islets. Nat Protoc. 2006; 1(1):429-35.Nat Protoc2006-01-01T00:00:002006In vivo multimodal imaging of transplanted pancreatic islets.2204056Thorens B, Weir GC, Leahy JL, Lodish HF, Bonner-Weir SProceedings of the National Academy of Sciences of the United States of AmericaReduced expression of the liver/beta-cell glucose transporter isoform in glucose-insensitive pancreatic beta cells of diabetic rats. Proc Natl Acad Sci U S A. 1990 Sep; 87(17):6492-6.Proc Natl Acad Sci U S A1990-09-01T00:00:001990Reduced expression of the liver/beta-cell glucose transporter isoform in glucose-insensitive pancreatic beta cells of diabetic rats.6102510Weir GC, Bonner-Weir S, Edwards DCEndocrine research communicationsNerve growth factor and pancreatic APUD cells. Endocr Res Commun. 1980; 7(1):71-5.Endocr Res Commun1980-01-01T00:00:001980Nerve growth factor and pancreatic APUD cells.6363171Trent DF, Fletcher DJ, May JM, Bonner-Weir S, Weir GCDiabetesAbnormal islet and adipocyte function in young B-cell-deficient rats with near-normoglycemia. Diabetes. 1984 Feb; 33(2):170-5.Diabetes1984-02-01T00:00:001984Abnormal islet and adipocyte function in young B-cell-deficient rats with near-normoglycemia.2645116Lee HC, Bonner-Weir S, Weir GC, Leahy JLEndocrinologyCompensatory adaption to partial pancreatectomy in the rat. Endocrinology. 1989 Mar; 124(3):1571-5.Endocrinology1989-03-01T00:00:001989Compensatory adaption to partial pancreatectomy in the rat.3282948Bonner-Weir SDiabetesMorphological evidence for pancreatic polarity of beta-cell within islets of Langerhans. Diabetes. 1988 May; 37(5):616-21.Diabetes1988-05-01T00:00:001988Morphological evidence for pancreatic polarity of beta-cell within islets of Langerhans.6112177Bonner-Weir S, Trent DF, Honey RN, Weir GCDiabetesResponses of neonatal rat islets to streptozotocin: limited B-cell regeneration and hyperglycemia. Diabetes. 1981 Jan; 30(1):64-9.Diabetes1981-01-01T00:00:001981Responses of neonatal rat islets to streptozotocin: limited B-cell regeneration and hyperglycemia.8376589Wang TC, Bonner-Weir S, Oates PS, Chulak M, Simon B, Merlino GT, Schmidt EV, Brand SJThe Journal of clinical investigationPancreatic gastrin stimulates islet differentiation of transforming growth factor alpha-induced ductular precursor cells. J Clin Invest. 1993 Sep; 92(3):1349-56.J Clin Invest1993-09-01T00:00:001993Pancreatic gastrin stimulates islet differentiation of transforming growth factor alpha-induced ductular precursor cells.20173775Aguayo-Mazzucato C, Bonner-Weir SNature reviews. EndocrinologyStem cell therapy for type 1 diabetes mellitus. Nat Rev Endocrinol. 2010 Mar; 6(3):139-48.Nat Rev Endocrinol2010-03-01T00:00:002010Stem cell therapy for type 1 diabetes mellitus.21865653Weir GC, Bonner-Weir SThe Journal of clinical investigationFinally! A human pancreatic ß cell line. J Clin Invest. 2011 Sep; 121(9):3395-7.J Clin Invest2011-08-25T00:00:002011Finally! A human pancreatic ß cell line.381098Bonner-Weir S, Weir GCGeneral and comparative endocrinologyThe organization of the endocrine pancreas: a hypothetical unifying view of the phylogenetic differences. Gen Comp Endocrinol. 1979 May; 38(1):28-37.Gen Comp Endocrinol1979-05-01T00:00:001979The organization of the endocrine pancreas: a hypothetical unifying view of the phylogenetic differences.3550372Colella RM, May JM, Bonner-Weir S, Leahy JL, Weir GCMetabolism: clinical and experimentalGlucose utilization in islets of hyperglycemic rat models with impaired glucose-induced insulin secretion. Metabolism. 1987 Apr; 36(4):335-7.Metabolism1987-04-01T00:00:001987Glucose utilization in islets of hyperglycemic rat models with impaired glucose-induced insulin secretion.7813817Ogawa Y, Noma Y, Davalli AM, Wu YJ, Thorens B, Bonner-Weir S, Weir GCDiabetesLoss of glucose-induced insulin secretion and GLUT2 expression in transplanted beta-cells. Diabetes. 1995 Jan; 44(1):75-9.Diabetes1995-01-01T00:00:001995Loss of glucose-induced insulin secretion and GLUT2 expression in transplanted beta-cells.7909632Montaña E, Bonner-Weir S, Weir GCTransplantation proceedingsTransplanted beta-cell replication and mass increase after 95% pancreatectomy. Transplant Proc. 1994 Apr; 26(2):657.Transplant Proc1994-04-01T00:00:001994Transplanted beta-cell replication and mass increase after 95% pancreatectomy.20697378Pisania A, Weir GC, O'Neil JJ, Omer A, Tchipashvili V, Lei J, Colton CK, Bonner-Weir SLaboratory investigation; a journal of technical methods and pathologyQuantitative analysis of cell composition and purity of human pancreatic islet preparations. Lab Invest. 2010 Nov; 90(11):1661-75.Lab Invest2010-08-09T00:00:002010Quantitative analysis of cell composition and purity of human pancreatic islet preparations.3292318Brockenbrough JS, Weir GC, Bonner-Weir SDiabetesDiscordance of exocrine and endocrine growth after 90% pancreatectomy in rats. Diabetes. 1988 Feb; 37(2):232-6.Diabetes1988-02-01T00:00:001988Discordance of exocrine and endocrine growth after 90% pancreatectomy in rats.7588296Scaglia L, Smith FE, Bonner-Weir SEndocrinologyApoptosis contributes to the involution of beta cell mass in the post partum rat pancreas. Endocrinology. 1995 Dec; 136(12):5461-8.Endocrinology1995-12-01T00:00:001995Apoptosis contributes to the involution of beta cell mass in the post partum rat pancreas.18971437Bonner-Weir S, O'Brien TDDiabetesIslets in type 2 diabetes: in honor of Dr. Robert C. Turner. Diabetes. 2008 Nov; 57(11):2899-904.Diabetes2008-11-01T00:00:002008Islets in type 2 diabetes: in honor of Dr. Robert C. Turner.19052237Inada A, Nienaber C, Katsuta H, Fujitani Y, Levine J, Morita R, Sharma A, Bonner-Weir SProceedings of the National Academy of Sciences of the United States of AmericaCarbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth. Proc Natl Acad Sci U S A. 2008 Dec 16; 105(50):19915-9.Proc Natl Acad Sci U S A2008-12-03T00:00:002008Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth.22673995Sarruf DA, Bonner-Weir S, Schwartz MWNature medicineNew clues to bariatric surgery's benefits. Nat Med. 2012 Jun 06; 18(6):860-1.Nat Med2012-06-06T00:00:002012New clues to bariatric surgery's benefits.9869866Weir GC, Quickel RR, Yoon KH, Tatarkiewicz K, Ulrich TR, Hollister-Lock J, Bonner-Weir SAnnals of transplantationPorcine neonatal pancreatic cell clusters (NPCCs): a potential source of tissue for islet transplantation. Ann Transplant. 1997; 2(3):63-8.Ann Transplant1997-01-01T00:00:001997Porcine neonatal pancreatic cell clusters (NPCCs): a potential source of tissue for islet transplantation.10830272Bonner-Weir SEndocrinologyPerspective: Postnatal pancreatic beta cell growth. Endocrinology. 2000 Jun; 141(6):1926-9.Endocrinology2000-06-01T00:00:002000Perspective: Postnatal pancreatic beta cell growth.11390407Kaneto H, Xu G, Song KH, Suzuma K, Bonner-Weir S, Sharma A, Weir GCThe Journal of biological chemistryActivation of the hexosamine pathway leads to deterioration of pancreatic beta-cell function through the induction of oxidative stress. J Biol Chem. 2001 Aug 17; 276(33):31099-104.J Biol Chem2001-06-04T00:00:002001Activation of the hexosamine pathway leads to deterioration of pancreatic beta-cell function through the induction of oxidative stress.11435959Tatarkiewicz K, Garcia M, Lopez-Avalos M, Bonner-Weir S, Weir GCTransplantationPorcine neonatal pancreatic cell clusters in tissue culture: benefits of serum and immobilization in alginate hydrogel. Transplantation. 2001 Jun 15; 71(11):1518-26.Transplantation2001-06-15T00:00:002001Porcine neonatal pancreatic cell clusters in tissue culture: benefits of serum and immobilization in alginate hydrogel.15304352Matsushita M, Noguchi H, Lu YF, Tomizawa K, Michiue H, Li ST, Hirose K, Bonner-Weir S, Matsui HFEBS lettersPhoto-acceleration of protein release from endosome in the protein transduction system. FEBS Lett. 2004 Aug 13; 572(1-3):221-6.FEBS Lett2004-08-13T00:00:002004Photo-acceleration of protein release from endosome in the protein transduction system.9679817Suzuki K, Bonner-Weir S, Trivedi N, Yoon KH, Hollister-Lock J, Colton CK, Weir GCTransplantationFunction and survival of macroencapsulated syngeneic islets transplanted into streptozocin-diabetic mice. Transplantation. 1998 Jul 15; 66(1):21-8.Transplantation1998-07-15T00:00:001998Function and survival of macroencapsulated syngeneic islets transplanted into streptozocin-diabetic mice.Authorship 10147116186386Noguchi H, Bonner-Weir S, Wei FY, Matsushita M, Matsumoto SDiabetesBETA2/NeuroD protein can be transduced into cells due to an arginine- and lysine-rich sequence. Diabetes. 2005 Oct; 54(10):2859-66.Diabetes2005-10-01T00:00:002005BETA2/NeuroD protein can be transduced into cells due to an arginine- and lysine-rich sequence.10329974Finegood DT, Weir GC, Bonner-Weir SThe American journal of physiologyPrior streptozotocin treatment does not inhibit pancreas regeneration after 90% pancreatectomy in rats. Am J Physiol. 1999 05; 276(5):E822-7.Am J Physiol1999-05-01T00:00:001999Prior streptozotocin treatment does not inhibit pancreas regeneration after 90% pancreatectomy in rats.6759221Bonner-Weir S, Orci LDiabetesNew perspectives on the microvasculature of the islets of Langerhans in the rat. Diabetes. 1982 Oct; 31(10):883-9.Diabetes1982-10-01T00:00:001982New perspectives on the microvasculature of the islets of Langerhans in the rat.10580413Xu G, Stoffers DA, Habener JF, Bonner-Weir SDiabetesExendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats. Diabetes. 1999 Dec; 48(12):2270-6.Diabetes1999-12-01T00:00:001999Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats.9038347Brüning JC, Winnay J, Bonner-Weir S, Taylor SI, Accili D, Kahn CRCellDevelopment of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles. Cell. 1997 Feb 21; 88(4):561-72.Cell1997-02-21T00:00:001997Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles.