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Gyorgy Baffy, M.D., Ph.D.

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Biography
education and training
University of Debrecen, Debrecen, HungaryMD1980Medicine
University of Debrecen, Debrecen, Hungary1987Gastroenterology
University of Pennsylvania, Philadelphia, PA1993Biochemistry
National Academy of Sciences, Budapest, HungaryPhD1994Medicine
University of Michigan, Ann Arbor, MI1996Gastroenterology
Brigham and Women's Hospital, Boston, MA2001Gastroenterology
awards and honors
1990
OMGE Young Investigator Scholarship
1991 - 1993
NIH Fogarty Fellow
1994
Rolf Madaus Prize
2010
Geza Hetenyi Award
2014 - 2015
US Fulbright Scholar Award
2017
Pro Optimo Merito in Gastroenterologia

Overview
overview
Dr. Gyorgy Baffy is an Associate Professor of Medicine at Harvard Medical School and Chief of Gastroenterology at the VA Boston Healthcare System. He is a graduate of the University Medical School of Debrecen in Hungary. He received his PhD from his studies conducted on growth factor-mediated calcium signaling in hepatocytes as an NIH Fogarty Fellow in the Department of Biochemistry and Biophysics at the University of Pennsylvania. He trained in gastroenterology at the University of Michigan and the Brigham and Women’s Hospital. His research interests focus on various aspects of NAFLD such as risk stratification, biomarkers, metabolic reprogramming, cancer bioenergetics, pathophysiology of portal hypertension, and development of hepatocellular carcinoma. He has been involved in several clinical trials related to cirrhosis management and colorectal cancer screening. He developed and organized multiple regional, national, and international workshops and symposia. He published over 100 peer-reviewed papers and book chapters. He has been a member of various scientific review panels and provides editorial work for major journals in gastroenterology and hepatology. In 2014, he received a Fulbright US Scholar award to teach for a semester about obesity and related disorders at the University of Debrecen. He is a Fellow of the American College of Physicians, American College of Gastroenterology, American Gastroenterological Association, and the American Association for the Study of Liver Diseases. He is the recipient of the Madaus Prize from the Madaus Liver Foundation and the Hetényi Medal and Pro Optimo Merito in Gastroenterologia Award from the Hungarian Gastroenterological Association.
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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. CSP-2023 (IOANNOU, GEORGE / TADDEI, TAMAR) May 1, 2023 - Apr 30, 2032
    VA Office of Research & Development Cooperative Studies Program
    PREventing Liver Cancer Mortality through Imaging with Ultrasound vs. MRI (PREMIUM)
    Role Description: The main objective of this multicenter randomized controlled trial is to compare the efficacy of biannual ultrasound plus alpha-fetoprotein (AFP) vs. biannual abbreviated magnetic resonance imaging (MRI) plus AFP as cancer screening modalities for patients with cirrhosis with a primary outcome of HCC-related mortality.
    Role: Site Investigator
  2. 1I01 CX002010 (KAPLAN, DAVID / TADDEI, TAMAR) Oct 1, 2020 - Sep 30, 2025
    VA ORD Clinical Science Research & Development
    Effect of simvastatin on hepatic decompensation and death in subjects with high- risk compensated cirrhosis (SACRED: Statins and Cirrhosis: Reducing Events of Decompensation
    Role Description: The primary objective of this phase III, randomized, double-blind, placebo-controlled, multicenter trial is to demonstrate that statin therapy can reduce the rate of hepatic decompensation, hepatocellular carcinoma, all-cause mortality, and the need for liver transplantation
    Role: Site Investigator
  3. PAL-LIVER (NAVARRO, VICTOR / VERMA, MANISHA) Oct 1, 2017 - Sep 30, 2025
    Patient-Centered Outcomes Research Institute (PCORI)
    Introducing palliative care with the treatment of end stage liver disease: A randomized controlled trial
    Role Description: The main goal of this multicenter cluster randomized clinical project is to determine the benefits of hepatologist-led palliative care compared to the conventional approach of requesting palliative care consultations in the management of patients with end-stage liver disease
    Role: Site Investigator
  4. CSP-577 (DOMINITZ, JASON / ROBERTSON, DOUGLAS) May 1, 2012 - Sep 30, 2027
    VA Cooperative Studies
    Colonoscopy Versus Fecal Immunochemical Test in Reducing Mortality From Colorectal Cancer (CONFIRM)
    Role Description: The main goal of this study is to perform a large, simple, multicenter, randomized, parallel group trial directly comparing screening colonoscopy with annual fecal immunochemistry test (FIT) screening in 50,000 average risk individuals and determine whether colonoscopy is superior to FIT in the prevention of colorectal cancer mortality measured over 10 years.
    Role: Site Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
Displaying 25 of 109 total Publications Show all
  1. Niezen S, Morgan TR, Scott D, Yakovchenko V, Patton H, Spoutz P, Yao Y, Baffy G, Fuchs M, Bajaj JS, Ekanem NR, Dominitz JA, Rogal SS. Identifying and treating metabolic dysfunction-associated steatotic liver disease among at-risk Veterans. Am J Gastroenterol. 2025 Jan 07. PMID: 39774063.
    Citations:
    Fields: GasGastroenterology
  2. Wong YJ, Buckholz A, Sim A, Teng M, Wong R, Curry MP, De Roza MA, Baffy G, Teoh X, Chak E, Rustagi T, Chang J, Wong GW, Tandon P, Garcia-Tsao G, Abraldes JG, Mohanty A, Fortune B. Nonalcohol-related Cirrhosis Leads to Higher 6-week Mortality After Acute Variceal Bleeding Than Alcohol-related Cirrhosis. Clin Gastroenterol Hepatol. 2024 Dec 14. PMID: 39675401.
    Citations:
    Fields: GasGastroenterology
  3. Khalil M, Di Ciaula A, Mahdi L, Jaber N, Di Palo DM, Graziani A, Baffy G, Portincasa P. Unraveling the Role of the Human Gut Microbiome in Health and Diseases. Microorganisms. 2024 Nov 15; 12(11). PMID: 39597722; PMCID: PMC11596745.
    Citations:
  4. von Rosenvinge EC, Vela SA, Paine ER, Chang MF, Hanson BJ, Taddei T, Smalley WE, Dunbar KB, Khan NH, Kahng LS, Anwar J, Zing R, Gawron A, Dominitz JA, Baffy G. A Crisis in Scope: Recruitment and Retention Challenges Reported by VA Gastroenterology Section Chiefs. Fed Pract. 2024 Aug; 41(8):256-260. PMID: 39410921; PMCID: PMC11473028.
    Citations:
  5. Di Ciaula A, Khalil M, Baffy G, Portincasa P. Advances in the pathophysiology, diagnosis and management of chronic diarrhoea from bile acid malabsorption: a systematic review. Eur J Intern Med. 2024 Oct; 128:10-19. PMID: 39069430.
    Citations: 1
    Translation:Humans
  6. Baffy G, Portincasa P. Gut Microbiota and Sinusoidal Vasoregulation in MASLD: A Portal Perspective. Metabolites. 2024 Jun 07; 14(6). PMID: 38921459; PMCID: PMC11205793.
    Citations: 1
  7. Portincasa P, Khalil M, Mahdi L, Perniola V, Idone V, Graziani A, Baffy G, Di Ciaula A. Metabolic Dysfunction-Associated Steatotic Liver Disease: From Pathogenesis to Current Therapeutic Options. Int J Mol Sci. 2024 May 22; 25(11). PMID: 38891828; PMCID: PMC11172019.
    Citations: 6
    Fields: BioBiochemistryCheChemistryMolMolecular BiologyTranslation:HumansAnimals
  8. Portincasa P, Baffy G. Metabolic dysfunction-associated steatotic liver disease: Evolution of the final terminology. Eur J Intern Med. 2024 Jun; 124:35-39. PMID: 38653634.
    Citations: 2
    Translation:Humans
  9. McCurdy H, Nobbe A, Scott D, Patton H, Morgan TR, Bajaj JS, Yakovchenko V, Merante M, Gibson S, Lamorte C, Baffy G, Ioannou GN, Taddei TH, Rozenberg-Ben-Dror K, Anwar J, Dominitz JA, Rogal SS. Organizational and Implementation Factors Associated with Cirrhosis Care in the Veterans Health Administration. Dig Dis Sci. 2024 Jun; 69(6):2008-2017. PMID: 38616215.
    Citations:
    Fields: GasGastroenterologyTranslation:Humans
  10. Portincasa P, Khalil M, Graziani A, Frühbeck G, Baffy G, Garruti G, Di Ciaula A, Bonfrate L. Gut microbes in metabolic disturbances. Promising role for therapeutic manipulations? Eur J Intern Med. 2024 Jan; 119:13-30. PMID: 37802720.
    Citations: 12
    Translation:Humans
  11. Buckholz A, Wong R, Curry MP, Baffy G, Chak E, Rustagi T, Mohanty A, Fortune BE. MELD, MELD 3.0, versus Child score to predict mortality after acute variceal hemorrhage: A multicenter US cohort. Hepatol Commun. 2023 10 01; 7(10). PMID: 37695092; PMCID: PMC10497247.
    Citations: 3
    Fields: GasGastroenterologyTranslation:Humans
  12. Boustany A, Rahhal R, Mitri J, Onwuzo S, Abou Zeid HK, Baffy G, Martel M, Barkun AN, Asaad I. The impact of nonalcoholic fatty liver disease on inflammatory bowel disease-related hospitalization outcomes: a systematic review. Eur J Gastroenterol Hepatol. 2023 10 01; 35(10):1067-1074. PMID: 37577829.
    Citations: 3
    Translation:Humans
  13. Robertson DJ, Dominitz JA, Beed A, Boardman KD, Del Curto BJ, Guarino PD, Imperiale TF, LaCasse A, Larson MF, Gupta S, Lieberman D, Planeta B, Shaukat A, Sultan S, Menees SB, Saini SD, Schoenfeld P, Goebel S, von Rosenvinge EC, Baffy G, Halasz I, Pedrosa MC, Kahng LS, Cassim R, Greer KB, Kinnard MF, Bhatt DB, Dunbar KB, Harford WV, Mengshol JA, Olson JE, Patel SG, Antaki F, Fisher DA, Sullivan BA, Lenza C, Prajapati DN, Wong H, Beyth R, Lieb JG, Manlolo J, Ona FV, Cole RA, Khalaf N, Kahi CJ, Kohli DR, Rai T, Sharma P, Anastasiou J, Hagedorn C, Fernando RS, Jackson CS, Jamal MM, Lee RH, Merchant F, May FP, Pisegna JR, Omer E, Parajuli D, Said A, Nguyen TD, Tombazzi CR, Feldman PA, Jacob L, Koppelman RN, Lehenbauer KP, Desai DS, Madhoun MF, Tierney WM, Ho MQ, Hockman HJ, Lopez C, Carter Paulson E, Tobi M, Pinillos HL, Young M, Ho NC, Mascarenhas R, Promrat K, Mutha PR, Pandak WM, Shah T, Schubert M, Pancotto FS, Gawron AJ, Underwood AE, Ho SB, Magno-Pagatzaurtundua P, Toro DH, Beymer CH, Kaz AM, Elwing J, Gill JA, Goldsmith SF, Yao MD, Protiva P, Pohl H, Kyriakides T, CONFIRM Study Group. Baseline Features and Reasons for Nonparticipation in the Colonoscopy Versus Fecal Immunochemical Test in Reducing Mortality From Colorectal Cancer (CONFIRM) Study, a Colorectal Cancer Screening Trial. JAMA Netw Open. 2023 07 03; 6(7):e2321730. PMID: 37432690; PMCID: PMC10336619.
    Citations: 7
    Fields: MedMedicine (General)Translation:Humans
  14. Rinella ME, Lazarus JV, Ratziu V, Francque SM, Sanyal AJ, Kanwal F, Romero D, Abdelmalek MF, Anstee QM, Arab JP, Arrese M, Bataller R, Beuers U, Boursier J, Bugianesi E, Byrne CD, Castro Narro GE, Chowdhury A, Cortez-Pinto H, Cryer DR, Cusi K, El-Kassas M, Klein S, Eskridge W, Fan J, Gawrieh S, Guy CD, Harrison SA, Kim SU, Koot BG, Korenjak M, Kowdley KV, Lacaille F, Loomba R, Mitchell-Thain R, Morgan TR, Powell EE, Roden M, Romero-Gómez M, Silva M, Singh SP, Sookoian SC, Spearman CW, Tiniakos D, Valenti L, Vos MB, Wong VW, Xanthakos S, Yilmaz Y, Younossi Z, Hobbs A, Villota-Rivas M, Newsome PN, NAFLD Nomenclature consensus group. A multisociety Delphi consensus statement on new fatty liver disease nomenclature. Hepatology. 2023 12 01; 78(6):1966-1986. PMID: 37363821; PMCID: PMC10653297.
    Citations: 316
    Fields: GasGastroenterologyTranslation:Humans
  15. Rinella ME, Lazarus JV, Ratziu V, Francque SM, Sanyal AJ, Kanwal F, Romero D, Abdelmalek MF, Anstee QM, Arab JP, Arrese M, Bataller R, Beuers U, Boursier J, Bugianesi E, Byrne CD, Castro Narro GE, Chowdhury A, Cortez-Pinto H, Cryer DR, Cusi K, El-Kassas M, Klein S, Eskridge W, Fan J, Gawrieh S, Guy CD, Harrison SA, Kim SU, Koot BG, Korenjak M, Kowdley KV, Lacaille F, Loomba R, Mitchell-Thain R, Morgan TR, Powell EE, Roden M, Romero-Gómez M, Silva M, Singh SP, Sookoian SC, Spearman CW, Tiniakos D, Valenti L, Vos MB, Wong VW, Xanthakos S, Yilmaz Y, Younossi Z, Hobbs A, Villota-Rivas M, Newsome PN, NAFLD Nomenclature consensus group. A multisociety Delphi consensus statement on new fatty liver disease nomenclature. J Hepatol. 2023 12; 79(6):1542-1556. PMID: 37364790.
    Citations: 365
    Fields: GasGastroenterologyTranslation:Humans
  16. Lazarus JV, Mark HE, Allen AM, Arab JP, Carrieri P, Noureddin M, Alazawi W, Alkhouri N, Alqahtani SA, Arrese M, Bataller R, Berg T, Brennan PN, Burra P, Castro-Narro GE, Cortez-Pinto H, Cusi K, Dedes N, Duseja A, Francque SM, Hagström H, Huang TT, Wajcman DI, Kautz A, Kopka CJ, Krag A, Miller V, Newsome PN, Rinella ME, Romero D, Sarin SK, Silva M, Spearman CW, Tsochatzis EA, Valenti L, Villota-Rivas M, Zelber-Sagi S, Schattenberg JM, Wong VW, Younossi ZM, Healthy Livers, Healthy Lives Collaborators. A global research priority agenda to advance public health responses to fatty liver disease. J Hepatol. 2023 09; 79(3):618-634. PMID: 37353401.
    Citations: 19
    Fields: GasGastroenterologyTranslation:HumansPHPublic Health
  17. Mitten EK, Portincasa P, Baffy G. Portal Hypertension in Nonalcoholic Fatty Liver Disease: Challenges and Paradigms. J Clin Transl Hepatol. 2023 Oct 28; 11(5):1201-1211. PMID: 37577237; PMCID: PMC10412712.
    Citations: 2
  18. Mitten EK, Baffy G. Metab Target Organ Damage. Mechanobiology in the development and progression of non-alcoholic fatty liver disease: an updated review. 2023; 3:2. doi: 10.20517/mtod.2022.37.View Publication.
  19. Lonardo A, Mantovani A, Targher G, Baffy G. Nonalcoholic Fatty Liver Disease and Chronic Kidney Disease: Epidemiology, Pathogenesis, and Clinical and Research Implications. Int J Mol Sci. 2022 Nov 01; 23(21). PMID: 36362108; PMCID: PMC9654863.
    Citations: 9
    Fields: BioBiochemistryCheChemistryMolMolecular BiologyTranslation:Humans
  20. Mitten EK, Baffy G. Mechanotransduction in the pathogenesis of non-alcoholic fatty liver disease. J Hepatol. 2022 12; 77(6):1642-1656. PMID: 36063966.
    Citations: 15
    Fields: GasGastroenterologyTranslation:HumansCells
  21. Mitten EK, Baffy G. Microbiota transplantation in portal hypertension: promises and pitfalls. Clin Sci (Lond). 2022 03 31; 136(6):425-429. PMID: 35333331.
    Citations: 2
    Fields: MedMedicine (General)SciScienceTranslation:Animals
  22. Fekete M, Piroska M, Szily M, Erdei M, Jokkel Z, Szabo H, Littvay L, Baffy G, Tarnoki AD, Tarnoki DL. Heritability analysis of liver stiffness detected by ultrasound shear wave elastography: a twin study. Eur J Gastroenterol Hepatol. 2021 12 01; 33(1S Suppl 1):e766-e770. PMID: 34284414.
    Citations:
    Translation:Humans
  23. Imperiale TF, Daggy JK, Imler TD, Sherer EA, Kahi CJ, Larson J, Cardwell J, Johnson CS, Ahnen DJ, Antaki F, Ashley C, Baffy G, Dominitz JA, Hou J, Korsten MA, Nagar A, Promrat K, Robertson DJ, Saini S, Shergill A, Smalley WE. Prevalence of Advanced Colorectal Neoplasia in Veterans: Effects of Age, Sex, and Race/Ethnicity. J Clin Gastroenterol. 2021 Nov-Dec 01; 55(10):876-883. PMID: 34049372.
    Citations: 1
    Fields: GasGastroenterologyTranslation:Humans
  24. Baffy G, Bosch J. Overlooked subclinical portal hypertension in non-cirrhotic NAFLD: Is it real and how to measure it? J Hepatol. 2022 02; 76(2):458-463. PMID: 34606912.
    Citations: 16
    Fields: GasGastroenterologyTranslation:Humans
  25. Baffy G. Precision Cancer Medicine. Squeezed into defection? Nuclear displacement by steatosis activates YAP linked to oncogenic pathways in hepatocytes. 2021.View Publication.
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