FS19FrankScheerFrank A.J.L. Scheer, Ph.D.42.33710500000000-71.1023170000000035762Scheer, FrankCircadian RhythmsMetabolismCardiovascular SystemShift WorkCircadian MisalignmentGlucose ToleranceEnergy ExpenditureNutritionObesityDiabetesA.J.L.Dr. Frank A.J.L. Scheer is a Professor of Medicine at Harvard Medical School (HMS), a Senior Neuroscientist at Brigham and Women’s Hospital (BWH), and the Director of the Medical Chronobiology Program (MCP) at BWH, Boston. Dr. Scheer’s work focuses on influences of the endogenous circadian system and its disruption—such as with shift work—on cardiovascular, pulmonary, and metabolic regulation and disease states, including hypertension, asthma, obesity, and diabetes. Since 2005, Dr. Scheer has been funded continuously as Principal Investigator by the National Institutes of Health (NIH). Dr. Scheer has received numerous scientific awards, including the Young Investigator Award by the American Academy of Sleep Medicine, the Neal Miller Award by the Academy of Behavioral Medicine Research, and the Outstanding Scientific Achievement Award by the Sleep Research Society. Dr. Scheer is an Editorial Board Member of several peer-reviewed journals, including the American Journal of Cardiovascular Disease, the Neurobiology of Sleep and Circadian Rhythms, and Chronobiology International, and is an Associate Editor at the journals SLEEP and Frontiers in Sleep.
Trainees
- Undergraduate: Taneisha Benjamin, 2005; Thomas J. Shea, 2006-2007; Anna Dowdle, 2006-2008; Grace McKay-Corkum, 2012; Isadora Bozzi, 2012-2013; Lucas Vargas, 2013; Seth Morrison, 2019; Charles Zimmerman, 2023-2024.
- Masters: Mariya Kogan, 2007-2008; Kirk Krogsted, 2007-2013; Noortje Trienekens, 2011-2012; Ann-Cathrin Plennis, 2015;
- PhD student: Stefan E. Knapen, 2018 (internship); Yolanda Larriba, 2019 (internship); Olga Minaeva, 2021 (internship), Phillip Alexander Keller Andersen 2022-2023 (internship).
- Post-doctoral: Anne-Marie Chang, PhD, 2005 - 2011; Kun Hu, PhD, 2006-2007; Mikhail Litinski, MD, 2008-2009; Christopher J. Morris, PhD, 2010-2015; Wenli Zhang, MD 2011-2012; Matthew Butler, PhD 2011-2013; David Barr, PhD 2013-2015; Jingyi Qian, PhD 2015-2020; Andrew McHill, PhD 2016-2017; Sarah Chellappa, PhD 2016-2019; Nina Vujovic, PhD, 2017-2022; Ivy Cheung Mason, PhD, 2018-2023; Raphael Knaier, PhD, 2020-2022; Han-Chow Koh, PhD, 2022-present; Arman Arab, PhD, 2023-present.
- Junior Faculty: Lei Gao, MD 2018-2020; Jingyi Qian, PhD 2020-present; Jacqueline M. Lane, PhD 2018-2023; Fransisco Romo-Nava, MD, PhD 2020-2024; Kelly Zuromski, PhD 2020-2024; Eline H. van Roekel, PhD 2022-2025.
Teaching
- Course Co-Director (with Charles A. Czeisler), MCB 186, Sleep and Circadian Clocks: from Biology to Public Health, Harvard College, Cambridge, MA
- General Education Course Co-Director (with Charles A. Czeisler), Gen Ed 1038, Sleep, Harvard College, Cambridge, MA617/732-7014Professor of Medicinecatalyst:eCommonsLogineCommons Loginplugins:FeaturedVideosFeatured Videosprns:awardConferredByaward conferred byprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:mediaLinksmedia linksprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborProfilesRNS Plugin Instanceprns:pluginSearchableDataProfilesRNS Plugin Searchable Dataprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:trainingAtOrganizationeducational organizationprns:trainingLocationtraining locationprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:address2address line 2vivo:address3address line 3vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipvivo:awardOrHonorawards and honorsAward or Honor Receiptvivo:degreeEarneddegree earnedDepartmentvivo:descriptiondescriptionDivisionvivo:educationalTrainingeducation and trainingEducational Trainingvivo:freetextKeywordkeywordsGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:majorFieldmajor field of degreevivo:middleNamemiddle name or initialvivo:overviewoverviewvivo:personInPositionpositionsvivo:phoneNumberphonePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofvivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonAuthorship 10455343Authorship 1048952829440150Vetter C, Dashti HS, Lane JM, Anderson SG, Schernhammer ES, Rutter MK, Saxena R, Scheer FAJLDiabetes careNight Shift Work, Genetic Risk, and Type 2 Diabetes in the UK Biobank. Diabetes Care. 2018 04; 41(4):762-769.Diabetes Care2018-02-12T00:00:002018Night Shift Work, Genetic Risk, and Type 2 Diabetes in the UK Biobank.Scheer FAJL, Van Montfrans GA, Buijs RM. SleepChronic, but not acute, nighttime melatonin administration improves sleep quality in hypertensive patients. Sleep. 2004; 27:A329.2004-01-01T00:00:002004Chronic, but not acute, nighttime melatonin administration improves sleep quality in hypertensive patientsAuthorship 1053710629571565Lopez-Minguez J, Dashti HS, Madrid-Valero JJ, Madrid JA, Saxena R, Scheer FAJL, Ordoñana JR, Garaulet MClinical nutrition (Edinburgh, Scotland)Heritability of the timing of food intake. Clin Nutr. 2019 04; 38(2):767-773.Clin Nutr2018-03-12T00:00:002018Heritability of the timing of food intake.19784781Rüger M, Scheer FAReviews in endocrine & metabolic disordersEffects of circadian disruption on the cardiometabolic system. Rev Endocr Metab Disord. 2009 Dec; 10(4):245-60.Rev Endocr Metab Disord2009-12-01T00:00:002009Effects of circadian disruption on the cardiometabolic system.18539630Hu K, Scheer FA, Buijs RM, Shea SACardiovascular researchThe circadian pacemaker generates similar circadian rhythms in the fractal structure of heart rate in humans and rats. Cardiovasc Res. 2008 Oct 01; 80(1):62-8.Cardiovasc Res2008-06-06T00:00:002008The circadian pacemaker generates similar circadian rhythms in the fractal structure of heart rate in humans and rats.19202078Hu K, Van Someren EJ, Shea SA, Scheer FAProceedings of the National Academy of Sciences of the United States of AmericaReduction of scale invariance of activity fluctuations with aging and Alzheimer's disease: Involvement of the circadian pacemaker. Proc Natl Acad Sci U S A. 2009 Feb 24; 106(8):2490-4.Proc Natl Acad Sci U S A2009-02-06T00:00:002009Reduction of scale invariance of activity fluctuations with aging and Alzheimer's disease: Involvement of the circadian pacemaker.20484692Jung CM, Khalsa SB, Scheer FA, Cajochen C, Lockley SW, Czeisler CA, Wright KPJournal of biological rhythmsAcute effects of bright light exposure on cortisol levels. J Biol Rhythms. 2010 Jun; 25(3):208-16.J Biol Rhythms2010-06-01T00:00:002010Acute effects of bright light exposure on cortisol levels.Authorship 1065547529733807Li P, Yu L, Lim ASP, Buchman AS, Scheer FAJL, Shea SA, Schneider JA, Bennett DA, Hu KAlzheimer's & dementia : the journal of the Alzheimer's AssociationFractal regulation and incident Alzheimer's disease in elderly individuals. Alzheimers Dement. 2018 09; 14(9):1114-1125.Alzheimers Dement2018-05-04T00:00:002018Fractal regulation and incident Alzheimer's disease in elderly individuals.Authorship 1071439529862620Qian J, Dalla Man C, Morris CJ, Cobelli C, Scheer FAJLDiabetes, obesity & metabolismDifferential effects of the circadian system and circadian misalignment on insulin sensitivity and insulin secretion in humans. Diabetes Obes Metab. 2018 10; 20(10):2481-2485.Diabetes Obes Metab2018-07-02T00:00:002018Differential effects of the circadian system and circadian misalignment on insulin sensitivity and insulin secretion in humans.Shea SA, Hu K, Buijs RM, Scheer FAJL.SleepLesioning the suprachiasmatic nucleus abolishes ultradian rhythms of locomotor activity in rats. Sleep. 2007; 30:A58.2007-01-01T00:00:002007Lesioning the suprachiasmatic nucleus abolishes ultradian rhythms of locomotor activity in ratsBuijs RM, Hermes MLHJ, Dai J, Scheer FAJL, Kalsbeek A.Ter Horst GJ (ed). The Nervous System and the Heart.Circadian organization of the autonomic Nervous system. Ter Horst GJ (ed). The Nervous System and the Heart. 2000; 117-157.2000-01-01T00:00:002000Circadian organization of the autonomic Nervous systemEvoniuk H, Hilton MF, Scheer FAJL, Malhotra A, Shiels S, Sugarbaker R, Weiner M, Ayers RT, Massaro AF, Shea SA.SleepEffects of endogenous circadian rhythms, sleep and sleep deprivation on airway function in asthma explored with a constant routine protocol. Sleep. 2005; 28:A71.2005-01-01T00:00:002005Effects of endogenous circadian rhythms, sleep and sleep deprivation on airway function in asthma explored with a constant routine protocolAuthorship 1077362529965796Kolbe I, Carrasco-Benso MP, López-Mínguez J, Luján J, Scheer FAJL, Oster H, Garaulet MFASEB journal : official publication of the Federation of American Societies for Experimental BiologyCircadian period of luciferase expression shortens with age in human mature adipocytes from obese patients. FASEB J. 2019 01; 33(1):175-180.FASEB J2018-07-02T00:00:002018Circadian period of luciferase expression shortens with age in human mature adipocytes from obese patients.Frank A.J.L. ScheerJ Sleep ResSuprachiasmatic nucleus, environmental light, and metabolic state interact in the regulation of body temperature. J Sleep Res. 2006; 15(1):20.2006-01-01T00:00:002006Suprachiasmatic nucleus, environmental light, and metabolic state interact in the regulation of body temperatureAuthorship 10787081629987027Wefers J, van Moorsel D, Hansen J, Connell NJ, Havekes B, Hoeks J, van Marken Lichtenbelt WD, Duez H, Phielix E, Kalsbeek A, Boekschoten MV, Hooiveld GJ, Hesselink MKC, Kersten S, Staels B, Scheer FAJL, Schrauwen PProceedings of the National Academy of Sciences of the United States of AmericaCircadian misalignment induces fatty acid metabolism gene profiles and compromises insulin sensitivity in human skeletal muscle. Proc Natl Acad Sci U S A. 2018 07 24; 115(30):7789-7794.Proc Natl Acad Sci U S A2018-07-09T00:00:002018Circadian misalignment induces fatty acid metabolism gene profiles and compromises insulin sensitivity in human skeletal muscle.Shea SA, Scheer FAJL, Evoniuk HL, Shiels SA, Malhotra A, Sugarbaker R, Ayers RT, Okruch A, Weiner M, Rinzler S, Massaro AF, Hilton MF.Chronobiology IntRole of the endogenous circadian system in bronchoconstriction, airway inflammation and rescue medication use in asthma. Chronobiology Int. 2005.2005-01-01T00:00:002005Role of the endogenous circadian system in bronchoconstriction, airway inflammation and rescue medication use in asthmaHu K, Scheer FAJL, Buijs RM, Shea SA.SleepThe circadian pacemaker contributes to intrinsic scale-invariant patterns of cardiac dynamics across a wide range of time scales – Spanning 4-24 Hours. Sleep. 2007; 30:A58.2007-01-01T00:00:002007The circadian pacemaker contributes to intrinsic scale-invariant patterns of cardiac dynamics across a wide range of time scales – Spanning 4-24 HoursShea TJ, Hilton MF, Evoniuk H, Scheer FAJL.SleepCircadian effect on degree of sleep inertia present after awakening. Sleep. 2006; A67.2006-01-01T00:00:002006Circadian effect on degree of sleep inertia present after awakeningShea SA, Hilton MF, Malhotra A, Evoniuk H, Shiels S, Sugarbaker R, Ayers RT, Weiner M, Massaro AF, Scheer FAJL. SleepInteraction between effects of the circadian pacemaker and behavioral sleep-wake cycle on pulmonary function in asthma. Sleep. 2005; 28:A73.2005-01-01T00:00:002005Interaction between effects of the circadian pacemaker and behavioral sleep-wake cycle on pulmonary function in asthma19255424Scheer FA, Hilton MF, Mantzoros CS, Shea SAProceedings of the National Academy of Sciences of the United States of AmericaAdverse metabolic and cardiovascular consequences of circadian misalignment. Proc Natl Acad Sci U S A. 2009 Mar 17; 106(11):4453-8.Proc Natl Acad Sci U S A2009-03-02T00:00:002009Adverse metabolic and cardiovascular consequences of circadian misalignment.23024438Scheer FA, Morris CJ, Garcia JI, Smales C, Kelly EE, Marks J, Malhotra A, Shea SASleepRepeated melatonin supplementation improves sleep in hypertensive patients treated with beta-blockers: a randomized controlled trial. Sleep. 2012 Oct 01; 35(10):1395-402.Sleep2012-10-01T00:00:002012Repeated melatonin supplementation improves sleep in hypertensive patients treated with beta-blockers: a randomized controlled trial.20703446Scheer FA, Chan JL, Fargnoli J, Chamberland J, Arampatzi K, Shea SA, Blackburn GL, Mantzoros CSDiabetologiaDay/night variations of high-molecular-weight adiponectin and lipocalin-2 in healthy men studied under fed and fasted conditions. Diabetologia. 2010 Nov; 53(11):2401-5.Diabetologia2010-08-12T00:00:002010Day/night variations of high-molecular-weight adiponectin and lipocalin-2 in healthy men studied under fed and fasted conditions.30232416Qian J, Morris CJ, Caputo R, Garaulet M, Scheer FAJLInternational journal of obesity (2005)Ghrelin is impacted by the endogenous circadian system and by circadian misalignment in humans. Int J Obes (Lond). 2019 08; 43(8):1644-1649.Int J Obes (Lond)2018-09-19T00:00:002018Ghrelin is impacted by the endogenous circadian system and by circadian misalignment in humans.Authorship 10939715Scheer FAJL, Hilton MF, Benjamin T, Barb D, Evoniuk H, Mantzoros CS, Shea SA. SleepDesynchrony between sleep-wake cycle and circadian cycle leads to suppressed plasma leptin; potential relevance for shift workers. Sleep. 2007; 30:A61.2007-01-01T00:00:002007Desynchrony between sleep-wake cycle and circadian cycle leads to suppressed plasma leptin; potential relevance for shift workersScheer FAJL, Cajochen C, Turek FW, Czeisler CA. Kryger MH, Roth T, Dement WC (ed). Principles and Practice of Sleep Medicine.Melatonin in the regulation of sleep and circadian rhythms. Kryger MH, Roth T, Dement WC (ed). Principles and Practice of Sleep Medicine. 2005; 395-404.2005-01-01T00:00:002005Melatonin in the regulation of sleep and circadian rhythms21474818Shea SA, Hilton MF, Hu K, Scheer FACirculation researchExistence of an endogenous circadian blood pressure rhythm in humans that peaks in the evening. Circ Res. 2011 Apr 15; 108(8):980-4.Circ Res2011-04-07T00:00:002011Existence of an endogenous circadian blood pressure rhythm in humans that peaks in the evening.22877674Morris CJ, Yang JN, Scheer FAJLProgress in brain researchThe impact of the circadian timing system on cardiovascular and metabolic function. Prog Brain Res. 2012; 199:337-358.Prog Brain Res2012-01-01T00:00:002012The impact of the circadian timing system on cardiovascular and metabolic function.Sleep Research Society2019Outstanding Scientific Achievement Award, Sleep Research Society16364835Scheer FAAmerican journal of hypertensionPotential use of melatonin as adjunct antihypertensive therapy. Am J Hypertens. 2005 Dec; 18(12 Pt 1):1619-20.Am J Hypertens2005-12-01T00:00:002005Potential use of melatonin as adjunct antihypertensive therapy.Authorship 1119460230531917Stenvers DJ, Scheer FAJL, Schrauwen P, la Fleur SE, Kalsbeek ANature reviews. EndocrinologyCircadian clocks and insulin resistance. Nat Rev Endocrinol. 2019 02; 15(2):75-89.Nat Rev Endocrinol2019-02-01T00:00:002019Circadian clocks and insulin resistance.Evoniuk HL, Scheer FAJL, Hilton MF, Schory KE, Shea SA.SleepChallenges to sleep in asthma studied under baseline conditions, reduced homeostatic sleep drive, and adverse circadian phase for sleep. Sleep. 2006.2006-01-01T00:00:002006Challenges to sleep in asthma studied under baseline conditions, reduced homeostatic sleep drive, and adverse circadian phase for sleep18487418Hu K, Scheer FA, Buijs RM, Shea SAJournal of biological rhythmsThe endogenous circadian pacemaker imparts a scale-invariant pattern of heart rate fluctuations across time scales spanning minutes to 24 hours. J Biol Rhythms. 2008 Jun; 23(3):265-73.J Biol Rhythms2008-06-01T00:00:002008The endogenous circadian pacemaker imparts a scale-invariant pattern of heart rate fluctuations across time scales spanning minutes to 24 hours.21059915Scheer FA, Hu K, Evoniuk H, Kelly EE, Malhotra A, Hilton MF, Shea SAProceedings of the National Academy of Sciences of the United States of AmericaImpact of the human circadian system, exercise, and their interaction on cardiovascular function. Proc Natl Acad Sci U S A. 2010 Nov 23; 107(47):20541-6.Proc Natl Acad Sci U S A2010-11-08T00:00:002010Impact of the human circadian system, exercise, and their interaction on cardiovascular function.Authorship 11281171Authorship 1128337330682628Scheer FAJL, Chellappa SL, Hu K, Shea SAPsychoneuroendocrinologyImpact of mental stress, the circadian system and their interaction on human cardiovascular function. Psychoneuroendocrinology. 2019 05; 103:125-129.Psychoneuroendocrinology2019-01-16T00:00:002019Impact of mental stress, the circadian system and their interaction on human cardiovascular function.30679522Chellappa SL, Morris CJ, Scheer FAJLScientific reportsEffects of circadian misalignment on cognition in chronic shift workers. Sci Rep. 2019 01 24; 9(1):699.Sci Rep2019-01-24T00:00:002019Effects of circadian misalignment on cognition in chronic shift workers.Shea SA, Scheer FAJL, Hilton MF.SleepPredicting the daily pattern of asthma severity based on the relative contribution of the circadian timing system, the sleep-wake cycle and the environment. Sleep. 2007; 30:A65.2007-01-01T00:00:002007Predicting the daily pattern of asthma severity based on the relative contribution of the circadian timing system, the sleep-wake cycle and the environmentAuthorship 1129503330705391Xiao Q, Garaulet M, Scheer FAJLInternational journal of obesity (2005)Meal timing and obesity: interactions with macronutrient intake and chronotype. Int J Obes (Lond). 2019 09; 43(9):1701-1711.Int J Obes (Lond)2019-01-31T00:00:002019Meal timing and obesity: interactions with macronutrient intake and chronotype.30722058Gao L, Li P, Hu C, To T, Patxot M, Falvey B, Wong PM, Scheer FAJL, Lin C, Lo MT, Hu KSleepNocturnal heart rate variability moderates the association between sleep-wake regularity and mood in young adults. Sleep. 2019 05 01; 42(5).Sleep2019-05-01T00:00:002019Nocturnal heart rate variability moderates the association between sleep-wake regularity and mood in young adults.Authorship 11302718Authorship 1130463230718862Vetter C, Scheer FAJLNature reviews. EndocrinologyA healthy lifestyle - reducing T2DM risk in shift workers? Nat Rev Endocrinol. 2019 04; 15(4):194-196.Nat Rev Endocrinol2019-04-01T00:00:002019A healthy lifestyle - reducing T2DM risk in shift workers?Authorship 113446820Authorship 11363497Authorship 11394012430804566Lane JM, Jones SE, Dashti HS, Wood AR, Aragam KG, van Hees VT, Strand LB, Winsvold BS, Wang H, Bowden J, Song Y, Patel K, Anderson SG, Beaumont RN, Bechtold DA, Cade BE, Haas M, Kathiresan S, Little MA, Luik AI, Loudon AS, Purcell S, Richmond RC, Scheer FAJL, Schormair B, Tyrrell J, Winkelman JW, Winkelmann J, Hveem K, Zhao C, Nielsen JB, Willer CJ, Redline S, Spiegelhalder K, Kyle SD, Ray DW, Zwart JA, Brumpton B, Frayling TM, Lawlor DA, Rutter MK, Weedon MN, Saxena RNature geneticsBiological and clinical insights from genetics of insomnia symptoms. Nat Genet. 2019 03; 51(3):387-393.Nat Genet2019-02-25T00:00:002019Biological and clinical insights from genetics of insomnia symptoms.30862011McHill AW, Czeisler CA, Phillips AJK, Keating L, Barger LK, Garaulet M, Scheer FAJL, Klerman EBNutrientsCaloric and Macronutrient Intake Differ with Circadian Phase and between Lean and Overweight Young Adults. Nutrients. 2019 03 11; 11(3).Nutrients2019-03-11T00:00:002019Caloric and Macronutrient Intake Differ with Circadian Phase and between Lean and Overweight Young Adults.30846698Dashti HS, Jones SE, Wood AR, Lane JM, van Hees VT, Wang H, Rhodes JA, Song Y, Patel K, Anderson SG, Beaumont RN, Bechtold DA, Bowden J, Cade BE, Garaulet M, Kyle SD, Little MA, Loudon AS, Luik AI, Scheer FAJL, Spiegelhalder K, Tyrrell J, Gottlieb DJ, Tiemeier H, Ray DW, Purcell SM, Frayling TM, Redline S, Lawlor DA, Rutter MK, Weedon MN, Saxena RNature communicationsGenome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates. Nat Commun. 2019 03 07; 10(1):1100.Nat Commun2019-03-07T00:00:002019Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates.D008550Chemicals & Drugs2127190.637763MelatoninD012890Physiology106045960.316774SleepD021081Disorders48740.90273Chronobiology DisordersAuthorship 11420992430926824Chang AM, Duffy JF, Buxton OM, Lane JM, Aeschbach D, Anderson C, Bjonnes AC, Cain SW, Cohen DA, Frayling TM, Gooley JJ, Jones SE, Klerman EB, Lockley SW, Munch M, Rajaratnam SMW, Rueger M, Rutter MK, Santhi N, Scheuermaier K, Van Reen E, Weedon MN, Czeisler CA, Scheer FAJL, Saxena RScientific reportsChronotype Genetic Variant in PER2 is Associated with Intrinsic Circadian Period in Humans. Sci Rep. 2019 03 29; 9(1):5350.Sci Rep2019-03-29T00:00:002019Chronotype Genetic Variant in PER2 is Associated with Intrinsic Circadian Period in Humans.Authorship 1150562231046092Dashti HS, Scheer FAJL, Saxena R, Garaulet MAdvances in nutrition (Bethesda, Md.)Timing of Food Intake: Identifying Contributing Factors to Design Effective Interventions. Adv Nutr. 2019 07 01; 10(4):606-620.Adv Nutr2019-07-01T00:00:002019Timing of Food Intake: Identifying Contributing Factors to Design Effective Interventions.D002940Concepts & Ideas75326140.422383Circadian RhythmD020178Disorders772220.792375Sleep Disorders, Circadian RhythmAnaesthesiaEpidemiologyMedicineNeurologyGen EdSleep MedicineBrigham and Women's HospitalFaculty of Arts & SciencesHarvard T.H. Chan School of Public HealthMassachusetts General HospitalEBK1ElizabethKlermanElizabeth Beryl Klerman, M.D., Ph.D.42.33710500000000-71.1023170000000049435Klerman, ElizabethProfessor of NeurologyESS5EvaSchernhammerEva S Schernhammer, D.P.H., M.D.42.33669100000000-71.1020890000000018449Schernhammer, EvaAdjunct Professor of EpidemiologySWL5StevenLockleySteven W. Lockley, Ph.D.42.33710500000000-71.1023170000000059875Lockley, StevenAssociate Professor of Medicine, Part-timeCAC5CharlesCzeislerCharles Andrew Czeisler, M.D., Ph.D.42.33710500000000-71.1023170000000024237Czeisler, CharlesFrank Baldino, Jr., Ph.D. Professor of Sleep MedicineSR165SusanRedlineSusan Redline, M.D.42.33710500000000-71.1023170000000027634Redline, SusanPeter C. Farrell Professor of Sleep Medicine11207selected publications12.19740.00797312363research areas7.981040.023983874coauthor of317.14827.778460similar toKH48KunHuKun Hu, Ph.D.42.33510370000000-71.1061649000000019112Hu, KunAssociate Professor of AnaesthesiaRS57RichaSaxenaRicha Saxena, Ph.D.42.36125700000000-71.065527000000002705Saxena, RichaProfessor of AnaesthesiaWW10WeiWangWei Wang, Ph.D.42.33710500000000-71.1023170000000026240Wang, WeiAssistant Professor of MedicineAuthorship 11605756Authorship 11605772431223959Guirette M, Dashti H, Tucker C, Vetter C, Garaulet M, Scheer F, Saxena RCurrent developments in nutritionHow Accurately Can We Recall Food Timing? A Validity Study of a Novel Food Timing Questionnaire (P18-016-19). Curr Dev Nutr. 2019 Jun; 3(Suppl 1).Curr Dev Nutr2019-06-13T00:00:002019How Accurately Can We Recall Food Timing? A Validity Study of a Novel Food Timing Questionnaire (P18-016-19).31190057Dashti HS, Merino J, Lane JM, Song Y, Smith CE, Tanaka T, McKeown NM, Tucker C, Sun D, Bartz TM, Li-Gao R, Nisa H, Reutrakul S, Lemaitre RN, Alshehri TM, de Mutsert R, Bazzano L, Qi L, Knutson KL, Psaty BM, Mook-Kanamori DO, Perica VB, Neuhouser ML, Scheer FAJL, Rutter MK, Garaulet M, Saxena RThe American journal of clinical nutritionGenome-wide association study of breakfast skipping links clock regulation with food timing. Am J Clin Nutr. 2019 08 01; 110(2):473-484.Am J Clin Nutr2019-08-01T00:00:002019Genome-wide association study of breakfast skipping links clock regulation with food timing.JFD1JeanneDuffyJeanne Frances Duffy, Ph.D.42.33710500000000-71.1023170000000017373Duffy, JeanneProfessor of MedicineSSK1Sat BirKhalsaSat Bir Singh Khalsa, Ph.D.42.33710500000000-71.1023170000000059415Khalsa, Sat BirAssociate Professor of MedicineSWR3ShanthakumarRajaratnamShanthakumar Wilson Rajaratnam, Ph.D.42.33710500000000-71.1023170000000068118Rajaratnam, ShanthakumarLecturer on Medicine, Part-timeJMR2JosephRondaJoseph Michael Ronda, M.S.42.33710500000000-71.1023170000000049466Ronda, JosephLecturer on MedicineAuthorship 11681521031249929Williams JS, Autori PJ, Kidd SK, Piazza G, Connors MC, Czeisler CA, Scheuermaier KD, Duffy J, Klerman EB, Scheer FA, Kozak M, Driscoll SM, Goldhaber SZTH open : companion journal to thrombosis and haemostasisHeparin-Induced Thrombocytopenia in Healthy Individuals with Continuous Heparin Infusion. TH Open. 2018 Jan; 2(1):e49-e53.TH Open2018-01-30T00:00:002018Heparin-Induced Thrombocytopenia in Healthy Individuals with Continuous Heparin Infusion.Authorship 1405431409809Wang H, Lane JM, Jones SE, Dashti HS, Ollila HM, Wood AR, van Hees VT, Brumpton B, Winsvold BS, Kantojärvi K, Palviainen T, Cade BE, Sofer T, Song Y, Patel K, Anderson SG, Bechtold DA, Bowden J, Emsley R, Kyle SD, Little MA, Loudon AS, Scheer FAJL, Purcell SM, Richmond RC, Spiegelhalder K, Tyrrell J, Zhu X, Hublin C, Kaprio JA, Kristiansson K, Sulkava S, Paunio T, Hveem K, Nielsen JB, Willer CJ, Zwart JA, Strand LB, Frayling TM, Ray D, Lawlor DA, Rutter MK, Weedon MN, Redline S, Saxena RNature communicationsGenome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes. Nat Commun. 2019 08 13; 10(1):3503.Nat Commun2019-08-13T00:00:002019Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes.31427142Chellappa SL, Vujovic N, Williams JS, Scheer FAJLTrends in endocrinology and metabolism: TEMImpact of Circadian Disruption on Cardiovascular Function and Disease. Trends Endocrinol Metab. 2019 10; 30(10):767-779.Trends Endocrinol Metab2019-08-16T00:00:002019Impact of Circadian Disruption on Cardiovascular Function and Disease.Authorship 118263023Authorship 11838594Authorship 1197816231616941Qian J, Scheer FA, Hu K, Shea SASleepThe circadian system modulates the rate of recovery of systolic blood pressure after exercise in humans. Sleep. 2020 04 15; 43(4).Sleep2020-04-15T00:00:002020The circadian system modulates the rate of recovery of systolic blood pressure after exercise in humans.31685618Qian J, Morris CJ, Caputo R, Wang W, Garaulet M, Scheer FAJLProceedings of the National Academy of Sciences of the United States of AmericaSex differences in the circadian misalignment effects on energy regulation. Proc Natl Acad Sci U S A. 2019 11 19; 116(47):23806-23812.Proc Natl Acad Sci U S A2019-11-04T00:00:002019Sex differences in the circadian misalignment effects on energy regulation.Authorship 1203108631723227Qian J, Scheer FAJLNature reviews. EndocrinologySex-dependent link between circadian misalignment and adiposity. Nat Rev Endocrinol. 2020 01; 16(1):13-15.Nat Rev Endocrinol2020-01-01T00:00:002020Sex-dependent link between circadian misalignment and adiposity.Authorship 12050472Authorship 1203750931757795Dashti HS, Vetter C, Lane JM, Smith MC, Wood AR, Weedon MN, Rutter MK, Garaulet M, Scheer FAJL, Saxena RDiabetesAssessment of MTNR1B Type 2 Diabetes Genetic Risk Modification by Shift Work and Morningness-Eveningness Preference in the UK Biobank. Diabetes. 2020 02; 69(2):259-266.Diabetes2019-11-22T00:00:002019Assessment of MTNR1B Type 2 Diabetes Genetic Risk Modification by Shift Work and Morningness-Eveningness Preference in the UK Biobank.true1Assistant Professor of MedicineAssistant Professor of MedicineAuthorship 1256441Authorship 137694131901302Garaulet M, Qian J, Florez JC, Arendt J, Saxena R, Scheer FAJLTrends in endocrinology and metabolism: TEMMelatonin Effects on Glucose Metabolism: Time To Unlock the Controversy. Trends Endocrinol Metab. 2020 03; 31(3):192-204.Trends Endocrinol Metab2020-01-01T00:00:002020Melatonin Effects on Glucose Metabolism: Time To Unlock the Controversy.31915891Mason IC, Qian J, Adler GK, Scheer FAJLDiabetologiaImpact of circadian disruption on glucose metabolism: implications for type 2 diabetes. Diabetologia. 2020 03; 63(3):462-472.Diabetologia2020-01-08T00:00:002020Impact of circadian disruption on glucose metabolism: implications for type 2 diabetes.Authorship 12173044Authorship 12171446Authorship 1218669631930347Sletten TL, Cappuccio FP, Davidson AJ, Van Cauter E, Rajaratnam SMW, Scheer FAJLSleepHealth consequences of circadian disruption. Sleep. 2020 01 13; 43(1).Sleep2020-01-13T00:00:002020Health consequences of circadian disruption.Authorship 1232238932192382Butler MP, Thosar SS, Smales C, DeYoung PN, Wu H, Hussain MV, Morimoto M, Hu K, Scheer FAJL, Shea SAChronobiology internationalEffects of obstructive sleep apnea on endogenous circadian rhythms assessed during relaxed wakefulness; an exploratory analysis. Chronobiol Int. 2020 06; 37(6):856-866.Chronobiol Int2020-03-20T00:00:002020Effects of obstructive sleep apnea on endogenous circadian rhythms assessed during relaxed wakefulness; an exploratory analysis.Authorship 1236533732234100Knapen SE, Li P, Riemersma-van der Lek RF, Verkooijen S, Boks MPM, Schoevers RA, Scheer FAJL, Hu KPsychological medicineFractal biomarker of activity in patients with bipolar disorder. Psychol Med. 2021 07; 51(9):1562-1569.Psychol Med2020-04-01T00:00:002020Fractal biomarker of activity in patients with bipolar disorder.05/1995Utrecht UniversityUtrecht, The NetherlandsUtrecht University, BiologyBSBiology05/1997Utrecht UniversityUtrecht, The NetherlandsUtrecht University, NeurophysiologyMScNeurophysiology01/2003Netherlands Institute for Brain ResearchAmsterdam, The NetherlandsNetherlands Institute for Brain Research, NeurosciencePhDNeuroscience06/2005Harvard Medical School, Brigham and Women’s HospitalBoston, USAHarvard Medical School, Brigham and Women’s Hospital, Sleep MedicinePostdoctoralSleep Medicine Circadian Rhythms and Your Health Circadian Rhythms and Your Health Harvard Medical School’s Longwood Seminarshttps://sleep.hms.harvard.edu/faculty-staff/frank-ajl-scheerHarvard Medical School-Division of Sleep Medicine Faculty Profilehttps://sleep.hms.harvard.edu/research/labs-divisions/medical-chronobiology-program-mcpMedical Chronobiology ProgramAuthorship 1238603632260404Kosmadopoulos A, Kervezee L, Boudreau P, Gonzales-Aste F, Vujovic N, Scheer FAJL, Boivin DBNutrientsEffects of Shift Work on the Eating Behavior of Police Officers on Patrol. Nutrients. 2020 Apr 04; 12(4).Nutrients2020-04-04T00:00:002020Effects of Shift Work on the Eating Behavior of Police Officers on Patrol.true1Professor of NeurologyProfessor of NeurologyAuthorship 198953132887712Xiao Q, Qian J, Evans DS, Redline S, Lane NE, Ancoli-Israel S, Scheer FAJL, Stone KDiabetes careCross-sectional and Prospective Associations of Rest-Activity Rhythms With Metabolic Markers and Type 2 Diabetes in Older Men. Diabetes Care. 2020 11; 43(11):2702-2712.Diabetes Care2020-09-04T00:00:002020Cross-sectional and Prospective Associations of Rest-Activity Rhythms With Metabolic Markers and Type 2 Diabetes in Older Men.Authorship 12815267Authorship 1289435532967204Martínez-Lozano N, Tvarijonaviciute A, Ríos R, Barón I, Scheer FAJL, Garaulet MNutrientsLate Eating Is Associated with Obesity, Inflammatory Markers and Circadian-Related Disturbances in School-Aged Children. Nutrients. 2020 09 21; 12(9).Nutrients2020-09-21T00:00:002020Late Eating Is Associated with Obesity, Inflammatory Markers and Circadian-Related Disturbances in School-Aged Children.https://gened.fas.harvard.edu/classes/sleepCourse at Harvard College General Education 1038: Sleep2004http://news.bbc.co.uk/2/hi/health/3410503.stmBBC News: “Sleep drug lowers blood pressure”2009http://www.scienceupdate.com/2009/03/night-shift-metabolismThe American Association for the Advancement of Science (audio): “Night Shift Metabolism”2013http://www.npr.org/blogs/thesalt/2013/01/30/170591028/NPR News (radio): "To Maximize Weight Loss, Eat Early in The Day, Not Late"2015http://radioboston.wbur.org/2015/04/13/circadian-rhythmsRadio Boston: You Are When You Eat (radio)2015http://www.npr.org/sections/thesalt/2015/03/10/389596946National Public Radio (NPR): “Circadian Surprise: How Our Body Clocks Help Shape Our Waistlines”33022698Dashti HS, Gómez-Abellán P, Qian J, Esteban A, Morales E, Scheer FAJL, Garaulet MThe American journal of clinical nutritionLate eating is associated with cardiometabolic risk traits, obesogenic behaviors, and impaired weight loss. Am J Clin Nutr. 2021 Jan 04; 113(1):154-161.Am J Clin Nutr2021-01-04T00:00:002021Late eating is associated with cardiometabolic risk traits, obesogenic behaviors, and impaired weight loss.Authorship 12929586Authorship 1293950732725188Arredondo-Amador M, Zambrano C, Kulyté A, Luján J, Hu K, Sánchez de Medina F, Scheer FAJL, Arner P, Ryden M, Martínez-Augustin O, Garaulet MThe Journal of clinical endocrinology and metabolismCircadian Rhythms in Hormone-sensitive Lipase in Human Adipose Tissue: Relationship to Meal Timing and Fasting Duration. J Clin Endocrinol Metab. 2020 12 01; 105(12).J Clin Endocrinol Metab2020-12-01T00:00:002020Circadian Rhythms in Hormone-sensitive Lipase in Human Adipose Tissue: Relationship to Meal Timing and Fasting Duration.Authorship 1300134333122670Chellappa SL, Morris CJ, Scheer FAJLScientific reportsCircadian misalignment increases mood vulnerability in simulated shift work. Sci Rep. 2020 10 29; 10(1):18614.Sci Rep2020-10-29T00:00:002020Circadian misalignment increases mood vulnerability in simulated shift work.33249510Qian J, Martinez-Lozano N, Tvarijonaviciute A, Rios R, Scheer FAJL, Garaulet MSleepBlunted rest-activity rhythms link to higher body mass index and inflammatory markers in children. Sleep. 2021 05 14; 44(5).Sleep2021-05-14T00:00:002021Blunted rest-activity rhythms link to higher body mass index and inflammatory markers in children.Authorship 1306227633199525Maidstone RJ, Turner J, Vetter C, Dashti HS, Saxena R, Scheer FAJL, Shea SA, Kyle SD, Lawlor DA, Loudon ASI, Blaikley JF, Rutter MK, Ray DW, Durrington HJThoraxNight shift work is associated with an increased risk of asthma. Thorax. 2021 01; 76(1):53-60.Thorax2020-11-16T00:00:002020Night shift work is associated with an increased risk of asthma.Authorship 13080086Authorship 1308331533257712McHill AW, Hilditch CJ, Fischer D, Czeisler CA, Garaulet M, Scheer FAJL, Klerman EBScientific reportsStability of the timing of food intake at daily and monthly timescales in young adults. Sci Rep. 2020 11 30; 10(1):20849.Sci Rep2020-11-30T00:00:002020Stability of the timing of food intake at daily and monthly timescales in young adults.33461311Gao L, Gaba A, Cui L, Yang HW, Saxena R, Scheer FAJL, Akeju O, Rutter MK, Lo MT, Hu K, Li PJournal of the American Heart AssociationResting Heartbeat Complexity Predicts All-Cause and Cardiorespiratory Mortality in Middle- to Older-Aged Adults From the UK Biobank. J Am Heart Assoc. 2021 02 02; 10(3):e018483.J Am Heart Assoc2021-01-19T00:00:002021Resting Heartbeat Complexity Predicts All-Cause and Cardiorespiratory Mortality in Middle- to Older-Aged Adults From the UK Biobank.Authorship 132141662020https://news.northwestern.edu/stories/2020/11/sleep-circadian-biology-leading-research/Keynote at 25th anniversary Center for Sleep and Circadian Biology, Northwestern University2017https://www.nytimes.com/2017/10/02/health/nobel-prize-medicine.html2017 Nobel Prize in Medicine Goes to 3 Americans for Body Clock Studieshttps://researchfaculty.brighamandwomens.org/BRIProfile.aspx?id=2303Brigham and Women's Hospital Faculty Profilehttps://orcid.org/0000-0002-2014-7582ORCID Profilehttps://scholar.google.com/citations?user=9eJOSjoAAAAJ&hl=enGoogle Scholar Profile33597215Qian J, Walkup MP, Chen SH, Brubaker PH, Bond DS, Richey PA, Jakicic JM, Hu K, Scheer FAJL, Middelbeek RJWDiabetes careAssociation of Objectively Measured Timing of Physical Activity Bouts With Cardiovascular Health in Type 2 Diabetes. Diabetes Care. 2021 04; 44(4):1046-1054.Diabetes Care2021-02-17T00:00:002021Association of Objectively Measured Timing of Physical Activity Bouts With Cardiovascular Health in Type 2 Diabetes.Authorship 1332304933822930Xiao Q, Qian J, Evans DS, Redline S, Lane NE, Ancoli-Israel S, Scheer FAJL, Stone KThe journals of gerontology. Series A, Biological sciences and medical sciencesCross-Sectional and Prospective Associations of Rest-Activity Rhythms With Circulating Inflammatory Markers in Older Men. J Gerontol A Biol Sci Med Sci. 2022 01 07; 77(1):55-65.J Gerontol A Biol Sci Med Sci2022-01-07T00:00:002022Cross-Sectional and Prospective Associations of Rest-Activity Rhythms With Circulating Inflammatory Markers in Older Men.Authorship 134331272021http://www.bwhresearch.org/obesityincubator/Keynote presentation from Frank A.J.L. Scheer at the 9th Annual Obesity Research Incubator Session2019https://www.aastweb.org/blog/qa-with-dr.-frank-scheer-aasts-2019-annual-meeting-keynote-speakerQ&A with Dr. Frank Scheer – AAST’s 2019 Annual Meeting Keynote SpeakerAuthorship 13523492133940951Lo EH, Albers GW, Dichgans M, Donnan G, Esposito E, Foster R, Howells DW, Huang YG, Ji X, Klerman EB, Lee S, Li W, Liebeskind DS, Lizasoain I, Mandeville ET, Moro MA, Ning M, Ray D, Sakadžic S, Saver JL, Scheer FAJL, Selim M, Tiedt S, Zhang F, Buchan AMStrokeCircadian Biology and Stroke. Stroke. 2021 06; 52(6):2180-2190.Stroke2021-05-04T00:00:002021Circadian Biology and Stroke.34142713Li P, Zheng X, Ulsa MC, Yang HW, Scheer FAJL, Rutter MK, Hu K, Gao LSleepPoor sleep behavior burden and risk of COVID-19 mortality and hospitalization. Sleep. 2021 08 13; 44(8).Sleep2021-08-13T00:00:002021Poor sleep behavior burden and risk of COVID-19 mortality and hospitalization.Authorship 136450252026-06-30SCHEER, FRANK A2021-07-01Food Timing to Mitigate Adverse Consequences of Night WorkR01HL153969Principal Investigatortrue1Associate Professor of Medicine, Part-timeAssociate Professor of Medicine, Part-timeAuthorship 1370000734164846Hernández-González T, González-Barrio R, Escobar C, Madrid JA, Periago MJ, Collado MC, Scheer FAJL, Garaulet MFASEB journal : official publication of the Federation of American Societies for Experimental BiologyTiming of chocolate intake affects hunger, substrate oxidation, and microbiota: A randomized controlled trial. FASEB J. 2021 07; 35(7):e21649.FASEB J2021-07-01T00:00:002021Timing of chocolate intake affects hunger, substrate oxidation, and microbiota: A randomized controlled trial.34431827Knaier R, Qian J, Roth R, Infanger D, Notter T, Wang W, Cajochen C, Scheer FAJLMedicine and science in sports and exerciseDiurnal Variation in Maximum Endurance and Maximum Strength Performance: A Systematic Review and Meta-analysis. Med Sci Sports Exerc. 2022 01 01; 54(1):169-180.Med Sci Sports Exerc2022-01-01T00:00:002022Diurnal Variation in Maximum Endurance and Maximum Strength Performance: A Systematic Review and Meta-analysis.Authorship 13880238Authorship 1392965134493686Scheer FAJL, Hilton MF, Evoniuk HL, Shiels SA, Malhotra A, Sugarbaker R, Ayers RT, Israel E, Massaro AF, Shea SAProceedings of the National Academy of Sciences of the United States of AmericaThe endogenous circadian system worsens asthma at night independent of sleep and other daily behavioral or environmental cycles. Proc Natl Acad Sci U S A. 2021 09 14; 118(37).Proc Natl Acad Sci U S A2021-09-14T00:00:002021The endogenous circadian system worsens asthma at night independent of sleep and other daily behavioral or environmental cycles.34558609Ulsa MC, Xi Z, Li P, Gaba A, Wong PM, Saxena R, Scheer FAJL, Rutter M, Akeju O, Hu K, Gao LThe journals of gerontology. Series A, Biological sciences and medical sciencesAssociation of Poor Sleep Burden in Middle Age and Older Adults With Risk for Delirium During Hospitalization. J Gerontol A Biol Sci Med Sci. 2022 03 03; 77(3):507-516.J Gerontol A Biol Sci Med Sci2022-03-03T00:00:002022Association of Poor Sleep Burden in Middle Age and Older Adults With Risk for Delirium During Hospitalization.Authorship 1396489734744800Yuan RK, Zitting KM, Duffy JF, Vujovic N, Wang W, Quan SF, Klerman EB, Scheer FAJL, Buxton OM, Williams JS, Czeisler CAFrontiers in physiologyChronic Sleep Restriction While Minimizing Circadian Disruption Does Not Adversely Affect Glucose Tolerance. Front Physiol. 2021; 12:764737.Front Physiol2021-10-20T00:00:002021Chronic Sleep Restriction While Minimizing Circadian Disruption Does Not Adversely Affect Glucose Tolerance.34861073Chellappa SL, Engen PA, Naqib A, Qian J, Vujovic N, Rahman N, Green SJ, Garaulet M, Keshavarzian A, Scheer FAJLFASEB journal : official publication of the Federation of American Societies for Experimental BiologyProof-of-principle demonstration of endogenous circadian system and circadian misalignment effects on human oral microbiota. FASEB J. 2022 01; 36(1):e22043.FASEB J2022-01-01T00:00:002022Proof-of-principle demonstration of endogenous circadian system and circadian misalignment effects on human oral microbiota.34860550Chellappa SL, Qian J, Vujovic N, Morris CJ, Nedeltcheva A, Nguyen H, Rahman N, Heng SW, Kelly L, Kerlin-Monteiro K, Srivastav S, Wang W, Aeschbach D, Czeisler CA, Shea SA, Adler GK, Garaulet M, Scheer FAJLScience advancesDaytime eating prevents internal circadian misalignment and glucose intolerance in night work. Sci Adv. 2021 Dec 03; 7(49):eabg9910.Sci Adv2021-12-03T00:00:002021Daytime eating prevents internal circadian misalignment and glucose intolerance in night work.Authorship 141029218Authorship 141038810Authorship 141198617Authorship 141066217Authorship 1413441834719257Delisle BP, George AL, Nerbonne JM, Bass JT, Ripplinger CM, Jain MK, Hermanstyne TO, Young ME, Kannankeril PJ, Duffy JF, Goldhaber JI, Hall MH, Somers VK, Smolensky MH, Garnett CE, Anafi RC, Scheer FAJL, Shivkumar K, Shea SA, Balijepalli RCCirculation. Arrhythmia and electrophysiologyUnderstanding Circadian Mechanisms of Sudden Cardiac Death: A Report From the National Heart, Lung, and Blood Institute Workshop, Part 2: Population and Clinical Considerations. Circ Arrhythm Electrophysiol. 2021 11; 14(11):e010190.Circ Arrhythm Electrophysiol2021-11-01T00:00:002021Understanding Circadian Mechanisms of Sudden Cardiac Death: A Report From the National Heart, Lung, and Blood Institute Workshop, Part 2: Population and Clinical Considerations.34719240Delisle BP, George AL, Nerbonne JM, Bass JT, Ripplinger CM, Jain MK, Hermanstyne TO, Young ME, Kannankeril PJ, Duffy JF, Goldhaber JI, Hall MH, Somers VK, Smolensky MH, Garnett CE, Anafi RC, Scheer FAJL, Shivkumar K, Shea SA, Balijepalli RCCirculation. Arrhythmia and electrophysiologyUnderstanding Circadian Mechanisms of Sudden Cardiac Death: A Report From the National Heart, Lung, and Blood Institute Workshop, Part 1: Basic and Translational Aspects. Circ Arrhythm Electrophysiol. 2021 11; 14(11):e010181.Circ Arrhythm Electrophysiol2021-11-01T00:00:002021Understanding Circadian Mechanisms of Sudden Cardiac Death: A Report From the National Heart, Lung, and Blood Institute Workshop, Part 1: Basic and Translational Aspects.34915199Gao L, Gaba A, Li P, Saxena R, Scheer FAJL, Akeju O, Rutter MK, Hu KJournal of sport and health scienceHeart rate response and recovery during exercise predict future delirium risk-A prospective cohort study in middle- to older-aged adults. J Sport Health Sci. 2023 05; 12(3):312-323.J Sport Health Sci2021-12-13T00:00:002021Heart rate response and recovery during exercise predict future delirium risk-A prospective cohort study in middle- to older-aged adults.Authorship 14203355Authorship 14215511035015083Garaulet M, Lopez-Minguez J, Dashti HS, Vetter C, Hernández-Martínez AM, Pérez-Ayala M, Baraza JC, Wang W, Florez JC, Scheer FAJL, Saxena RDiabetes careInterplay of Dinner Timing and MTNR1B Type 2 Diabetes Risk Variant on Glucose Tolerance and Insulin Secretion: A Randomized Crossover Trial. Diabetes Care. 2022 03 01; 45(3):512-519.Diabetes Care2022-03-01T00:00:002022Interplay of Dinner Timing and MTNR1B Type 2 Diabetes Risk Variant on Glucose Tolerance and Insulin Secretion: A Randomized Crossover Trial.Authorship 2130322true1Lecturer on MedicineLecturer on Medicine2021https://www.wired.com/story/why-does-asthma-get-worse-at-night/Wired: "Why Does Asthma Get Worse at Night?"2022https://www.newscientist.com/article/2300239-night-shift-workers-who-eat-only-in-the-day-may-cut-diaNew Scientist: "Night-shift workers who eat only in the day may cut diabetes risk Read more: https"2022https://www.sciencedaily.com/releases/2022/01/220125124032.htmScience Daily: "How the timing of dinner and genetics affect individuals’ blood sugar control"35133678Qian J, Morris CJ, Phillips AJK, Li P, Rahman SA, Wang W, Hu K, Arendt J, Czeisler CA, Scheer FAJLJournal of pineal researchUnanticipated daytime melatonin secretion on a simulated night shift schedule generates a distinctive 24-h melatonin rhythm with antiphasic daytime and nighttime peaks. J Pineal Res. 2022 Apr; 72(3):e12791.J Pineal Res2022-03-10T00:00:002022Unanticipated daytime melatonin secretion on a simulated night shift schedule generates a distinctive 24-h melatonin rhythm with antiphasic daytime and nighttime peaks.35150732Zitting KM, Vetrivelan R, Yuan RK, Vujovic N, Wang W, Bandaru SS, Quan SF, Klerman EB, Scheer FAJL, Buxton OM, Williams JS, Duffy JF, Saper CB, Czeisler CAMetabolism: clinical and experimentalChronic circadian disruption on a high-fat diet impairs glucose tolerance. Metabolism. 2022 05; 130:155158.Metabolism2022-02-09T00:00:002022Chronic circadian disruption on a high-fat diet impairs glucose tolerance.Authorship 143168410true1Associate Professor of MedicineAssociate Professor of MedicineAuthorship 14341179true1Lecturer on Medicine, Part-timeLecturer on Medicine, Part-timeAuthorship 1439821835198846Gioia SC, Guirette M, Chen A, Tucker C, Gray BE, Vetter C, Garaulet M, Scheer FAJL, Saxena R, Dashti HSCurrent developments in nutritionHow Accurately Can We Recall the Timing of Food Intake? A Comparison of Food Times from Recall-Based Survey Questions and Daily Food Records. Curr Dev Nutr. 2022 Feb; 6(2):nzac002.Curr Dev Nutr2022-01-10T00:00:002022How Accurately Can We Recall the Timing of Food Intake? A Comparison of Food Times from Recall-Based Survey Questions and Daily Food Records.Authorship 2756053true1Professor of AnaesthesiaProfessor of Anaesthesia35569055Grant LK, Coborn JE, Cohn A, Nathan MD, Scheer FAJL, Klerman EB, Kaiser UB, Harder J, Abramson M, Elguenaoui E, Russell JA, Wiley A, Rahman SA, Joffe HThe Journal of clinical endocrinology and metabolismSleep Fragmentation and Estradiol Suppression Decrease Fat Oxidation in Premenopausal Women. J Clin Endocrinol Metab. 2022 07 14; 107(8):e3167-e3176.J Clin Endocrinol Metab2022-07-14T00:00:002022Sleep Fragmentation and Estradiol Suppression Decrease Fat Oxidation in Premenopausal Women.Authorship 14515505Authorship 14571505Authorship 145715162022https://www.nature.com/articles/d41586-022-02211-yNature: "Can resetting the body clock help with depression?"36028773Lane JM, Qian J, Mignot E, Redline S, Scheer FAJL, Saxena RNature reviews. GeneticsGenetics of circadian rhythms and sleep in human health and disease. Nat Rev Genet. 2023 01; 24(1):4-20.Nat Rev Genet2022-08-26T00:00:002022Genetics of circadian rhythms and sleep in human health and disease.35765855McHill AW, Brown LS, Phillips AJK, Barger LK, Garaulet M, Scheer FAJL, Klerman EBObesity (Silver Spring, Md.)Later energy intake relative to mathematically modeled circadian time is associated with higher percentage body fat. Obesity (Silver Spring). 2023 02; 31 Suppl 1:50-56.Obesity (Silver Spring)2022-06-29T00:00:002022Later energy intake relative to mathematically modeled circadian time is associated with higher percentage body fat.36095195Qian J, Vujovic N, Nguyen H, Rahman N, Heng SW, Amira S, Scheer FAJL, Chellappa SLProceedings of the National Academy of Sciences of the United States of AmericaDaytime eating prevents mood vulnerability in night work. Proc Natl Acad Sci U S A. 2022 09 20; 119(38):e2206348119.Proc Natl Acad Sci U S A2022-09-12T00:00:002022Daytime eating prevents mood vulnerability in night work.Authorship 147019514Authorship 14701964Authorship 14701977Authorship 14701982836159463Romo-Nava F, Guerdjikova AI, Mori NN, Scheer FAJL, Burgess HJ, McNamara RK, Welge JA, Grilo CM, McElroy SLFrontiers in nutritionA matter of time: A systematic scoping review on a potential role of the circadian system in binge eating behavior. Front Nutr. 2022; 9:978412.Front Nutr2022-09-08T00:00:002022A matter of time: A systematic scoping review on a potential role of the circadian system in binge eating behavior.36055772Lee BY, Ordovás JM, Parks EJ, Anderson CAM, Barabási AL, Clinton SK, de la Haye K, Duffy VB, Franks PW, Ginexi EM, Hammond KJ, Hanlon EC, Hittle M, Ho E, Horn AL, Isaacson RS, Mabry PL, Malone S, Martin CK, Mattei J, Meydani SN, Nelson LM, Neuhouser ML, Parent B, Pronk NP, Roche HM, Saria S, Scheer FAJL, Segal E, Sevick MA, Spector TD, Van Horn L, Varady KA, Voruganti VS, Martinez MFThe American journal of clinical nutritionResearch gaps and opportunities in precision nutrition: an NIH workshop report. Am J Clin Nutr. 2022 12 19; 116(6):1877-1900.Am J Clin Nutr2022-12-19T00:00:002022Research gaps and opportunities in precision nutrition: an NIH workshop report.36198293Vujovic N, Piron MJ, Qian J, Chellappa SL, Nedeltcheva A, Barr D, Heng SW, Kerlin K, Srivastav S, Wang W, Shoji B, Garaulet M, Brady MJ, Scheer FAJLCell metabolismLate isocaloric eating increases hunger, decreases energy expenditure, and modifies metabolic pathways in adults with overweight and obesity. Cell Metab. 2022 10 04; 34(10):1486-1498.e7.Cell Metab2022-10-04T00:00:002022Late isocaloric eating increases hunger, decreases energy expenditure, and modifies metabolic pathways in adults with overweight and obesity.Authorship 1494572736275180Gao C, Li P, Morris CJ, Zheng X, Ulsa MC, Gao L, Scheer FAJL, Hu KNature and science of sleepActigraphy-Based Sleep Detection: Validation with Polysomnography and Comparison of Performance for Nighttime and Daytime Sleep During Simulated Shift Work. Nat Sci Sleep. 2022; 14:1801-1816.Nat Sci Sleep2022-10-14T00:00:002022Actigraphy-Based Sleep Detection: Validation with Polysomnography and Comparison of Performance for Nighttime and Daytime Sleep During Simulated Shift Work.Authorship 1504808736376588Wang W, Yuan RK, Mitchell JF, Zitting KM, St Hilaire MA, Wyatt JK, Scheer FAJL, Wright KP, Brown EN, Ronda JM, Klerman EB, Duffy JF, Dijk DJ, Czeisler CANature protocolsDesynchronizing the sleep---wake cycle from circadian timing to assess their separate contributions to physiology and behaviour and to estimate intrinsic circadian period. Nat Protoc. 2023 02; 18(2):579-603.Nat Protoc2022-11-14T00:00:002022Desynchronizing the sleep---wake cycle from circadian timing to assess their separate contributions to physiology and behaviour and to estimate intrinsic circadian period.Authorship 15126381636567263Klerman EB, Brager A, Carskadon MA, Depner CM, Foster R, Goel N, Harrington M, Holloway PM, Knauert MP, LeBourgeois MK, Lipton J, Merrow M, Montagnese S, Ning M, Ray D, Scheer FAJL, Shea SA, Skene DJ, Spies C, Staels B, St-Onge MP, Tiedt S, Zee PC, Burgess HJClinical and translational medicineKeeping an eye on circadian time in clinical research and medicine. Clin Transl Med. 2022 12; 12(12):e1131.Clin Transl Med2022-12-01T00:00:002022Keeping an eye on circadian time in clinical research and medicine.36808743Gao L, Li P, Gaykova N, Zheng X, Gao C, Lane JM, Saxena R, Scheer FAJL, Rutter MK, Akeju O, Hu KAnnals of neurologyCircadian Rest-Activity Rhythms, Delirium Risk, and Progression to Dementia. Ann Neurol. 2023 06; 93(6):1145-1157.Ann Neurol2023-03-03T00:00:002023Circadian Rest-Activity Rhythms, Delirium Risk, and Progression to Dementia.Authorship 1526829837075812Chen RW, Ulsa MC, Li P, Gao C, Zheng X, Xu J, Luo Y, Shen S, Lane J, Scheer FAJL, Hu K, Gao LSleepSleep behavior traits and associations with opioid-related adverse events: a cohort study. Sleep. 2023 09 08; 46(9).Sleep2023-09-08T00:00:002023Sleep behavior traits and associations with opioid-related adverse events: a cohort study.Mass General Brigham2023Pillars of Excellence Award, Mass General Brigham2022https://www.ctvnews.ca/video?clipId=2535819CTV News (video): “Eating Later Could Make You Hungrier”2022https://fortune.com/well/2022/10/04/late-night-eating-makes-you-hungry-and-burns-fewer-calories-new-Fortune: “When you eat matters: Late-night eating makes you hungry and burns fewer calories, new s2023https://www.247muscle.com/episodes/episode/1d15c04f/e13-part-1-health-risks-of-shift-work-and-how-to247Muscle Podcast: “E13 - Part 1: Health risks of shift work & how to minimize them”2023https://www.247muscle.com/episodes/episode/4b178146/e14-part-2-health-risks-of-shift-work-and-how-to247Muscle Podcast: “E14 - Part 2: Health risks of shift work & how to minimize them”2023https://www.washingtonpost.com/wellness/2023/01/10/meal-timing-big-meals/The Washington Post: “It’s not just what you eat, but the time of day you eat it”37207451Cohn AY, Grant LK, Nathan MD, Wiley A, Abramson M, Harder JA, Crawford S, Klerman EB, Scheer FAJL, Kaiser UB, Rahman SA, Joffe HThe Journal of clinical endocrinology and metabolismEffects of Sleep Fragmentation and Estradiol Decline on Cortisol in a Human Experimental Model of Menopause. J Clin Endocrinol Metab. 2023 10 18; 108(11):e1347-e1357.J Clin Endocrinol Metab2023-10-18T00:00:002023Effects of Sleep Fragmentation and Estradiol Decline on Cortisol in a Human Experimental Model of Menopause.37226675Qian J, Xiao Q, Walkup MP, Coday M, Erickson ML, Unick J, Jakicic JM, Hu K, Scheer FAJL, Middelbeek RJWDiabetes careAssociation of Timing of Moderate-to-Vigorous Physical Activity With Changes in Glycemic Control Over 4 Years in Adults With Type 2 Diabetes From the Look AHEAD Trial. Diabetes Care. 2023 07 01; 46(7):1417-1424.Diabetes Care2023-07-01T00:00:002023Association of Timing of Moderate-to-Vigorous Physical Activity With Changes in Glycemic Control Over 4 Years in Adults With Type 2 Diabetes From the Look AHEAD Trial.37208462Bruggisser F, Knaier R, Roth R, Wang W, Qian J, Scheer FAJLSports medicine - openBest Time of Day for Strength and Endurance Training to Improve Health and Performance? A Systematic Review with Meta-analysis. Sports Med Open. 2023 May 19; 9(1):34.Sports Med Open2023-05-19T00:00:002023Best Time of Day for Strength and Endurance Training to Improve Health and Performance? A Systematic Review with Meta-analysis.Canadian Society for Chronobiology2023Mrosovsky Keynote Lecture Award, Canadian Society for Chronobiologytrue1Assistant Professor of AnaesthesiaAssistant Professor of Anaesthesiatrue1Assistant Professor of MedicineAssistant Professor of Medicine37537954Qian J, Morris CJ, Caputo R, Scheer FAJLObesity (Silver Spring, Md.)Circadian misalignment increases 24-hour acylated ghrelin in chronic shift workers: a randomized crossover trial. Obesity (Silver Spring). 2023 09; 31(9):2235-2239.Obesity (Silver Spring)2023-08-03T00:00:002023Circadian misalignment increases 24-hour acylated ghrelin in chronic shift workers: a randomized crossover trial.Authorship 15710689Authorship 15702076Authorship 15699939Authorship 15590235Authorship 15653048Authorship 15582619Authorship 156411210Authorship 1558130737361522Zambrano C, Kulyté A, Luján J, Rivero-Gutierrez B, Sánchez de Medina F, Martínez-Augustin O, Ryden M, Scheer FAJL, Garaulet MFrontiers in endocrinologyHabitual nappers and non-nappers differ in circadian rhythms of LIPE expression in abdominal adipose tissue explants. Front Endocrinol (Lausanne). 2023; 14:1166961.Front Endocrinol (Lausanne)2023-06-09T00:00:002023Habitual nappers and non-nappers differ in circadian rhythms of LIPE expression in abdominal adipose tissue explants.37140408Garaulet M, Vizmanos B, Muela T, Betancourt-Núñez A, Bonmatí-Carrión MÁ, Vetter C, Dashti HS, Saxena R, Scheer FAJLObesity (Silver Spring, Md.)Evening types as determined by subjective and objective measures are more emotional eaters. Obesity (Silver Spring). 2023 05; 31(5):1192-1203.Obesity (Silver Spring)2023-05-01T00:00:002023Evening types as determined by subjective and objective measures are more emotional eaters.37292791Gao L, Zheng X, Baker SN, Li P, Scheer FAJL, Nogueira RC, Hu KmedRxiv : the preprint server for health sciencesAssociations of rest-activity rhythm disturbances with stroke risk and post-stroke adverse outcomes. medRxiv. 2023 May 16.medRxiv2023-05-16T00:00:002023Associations of rest-activity rhythm disturbances with stroke risk and post-stroke adverse outcomes.37140401Vizmanos B, Cascales AI, Rodríguez-Martín M, Salmerón D, Morales E, Aragón-Alonso A, Scheer FAJL, Garaulet MObesity (Silver Spring, Md.)Lifestyle mediators of associations among siestas, obesity, and metabolic health. Obesity (Silver Spring). 2023 05; 31(5):1227-1239.Obesity (Silver Spring)2023-05-01T00:00:002023Lifestyle mediators of associations among siestas, obesity, and metabolic health.37555446Vlasac IM, Bormes GW, Do E, Benkhoukha SS, Diallo N, Fryou NL, Gioia S, Akeju O, Joseph C, Kuan A, Lapan J, Oluwadara D, Team TP, Rahman SA, Saxena R, Scheer FAJL, Westover MB, Winkelman JW, Woodson F, Lane JMSleepA Novel Home-Based Study of Circadian Rhythms: Design, Rationale, and Methods for the Circadia Study. Sleep. 2023 Aug 09.Sleep2023-08-09T00:00:002023A Novel Home-Based Study of Circadian Rhythms: Design, Rationale, and Methods for the Circadia Study.37544031Arab A, Karimi E, Garaulet M, Scheer FAJLSleep medicine reviewsSocial jetlag and dietary intake: A systematic review. Sleep Med Rev. 2023 10; 71:101820.Sleep Med Rev2023-07-20T00:00:002023Social jetlag and dietary intake: A systematic review.Authorship 15860944Authorship 15929954Authorship 15905911Authorship 159352216Authorship 1592747437769026Larriba Y, Mason IC, Saxena R, Scheer FAJL, Rueda CPLoS computational biologyCIRCUST: A novel methodology for temporal order reconstruction of molecular rhythms; validation and application towards a daily rhythm gene expression atlas in humans. PLoS Comput Biol. 2023 Sep; 19(9):e1011510.PLoS Comput Biol2023-09-28T00:00:002023CIRCUST: A novel methodology for temporal order reconstruction of molecular rhythms; validation and application towards a daily rhythm gene expression atlas in humans.37648646Scheer FAJL, Chellappa SLSleep healthEndogenous circadian rhythms in mood and well-being. Sleep Health. 2023 Aug 28.Sleep Health2023-08-28T00:00:002023Endogenous circadian rhythms in mood and well-being.Authorship 1602180537873226Wallace DA, Qiu X, Schwartz J, Huang T, Scheer FAJL, Redline S, Sofer TmedRxiv : the preprint server for health sciencesLight exposure during sleep is associated with irregular sleep timing: the Multi-Ethnic Study of Atherosclerosis (MESA). medRxiv. 2023 Oct 12.medRxiv2023-10-12T00:00:002023Light exposure during sleep is associated with irregular sleep timing: the Multi-Ethnic Study of Atherosclerosis (MESA).Authorship 1607665637978840Heller HC, Herzog E, Brager A, Poe G, Allada R, Scheer F, Carskadon M, de la Iglesia HO, Jang R, Montero A, Wright K, Mouraine P, Walker MP, Goel N, Hogenesch J, Van Gelder RN, Kriegsfeld L, Mah C, Colwell C, Zeitzer J, Grandner M, Jackson CL, Roxanne Prichard J, Kay SA, Paul KJournal of biological rhythmsThe Negative Effects of Travel on Student Athletes Through Sleep and Circadian Disruption. J Biol Rhythms. 2024 Feb; 39(1):5-19.J Biol Rhythms2023-11-18T00:00:002023The Negative Effects of Travel on Student Athletes Through Sleep and Circadian Disruption.Authorship 1613558438072635Arab A, Karimi E, Garaulet M, Scheer FAJLObesity reviews : an official journal of the International Association for the Study of ObesitySocial jetlag and obesity: A systematic review and meta-analysis. Obes Rev. 2024 Mar; 25(3):e13664.Obes Rev2023-12-10T00:00:002023Social jetlag and obesity: A systematic review and meta-analysis.38159634Wallace DA, Qiu X, Schwartz J, Huang T, Scheer FAJL, Redline S, Sofer TEnvironmental pollution (Barking, Essex : 1987)Light exposure during sleep is bidirectionally associated with irregular sleep timing: The multi-ethnic study of atherosclerosis (MESA). Environ Pollut. 2024 Mar 01; 344:123258.Environ Pollut2023-12-28T00:00:002023Light exposure during sleep is bidirectionally associated with irregular sleep timing: The multi-ethnic study of atherosclerosis (MESA).2027-07-31SCHEER, FRANK A2023-08-01Effect of high fat diet on the circadian system and on circadian rhythms in energy intake and expenditureR01HL1677462028-06-30SCHEER, FRANK A2023-07-10Effect of temporal distribution of macronutrient intake on metabolismR01HL164454Principal InvestigatorThe major goals of this project are to determine whether macronutrient intake will alter the circadian system and thereby rhythms of energy balance regulation in human.Principal InvestigatorThe major goals of this project are to determine whether the temporal distribution of macronutrient intake will affect metabolism in humans.Authorship 16177225true1Professor of MedicineProfessor of Medicinetrue1Associate Professor of AnaesthesiaAssociate Professor of AnaesthesiaAuthorship 1623746238267484Dashti HS, Scheer FAJL, Saxena R, Garaulet MInternational journal of obesity (2005)Impact of polygenic score for BMI on weight loss effectiveness and genome-wide association analysis. Int J Obes (Lond). 2024 Jan 24.Int J Obes (Lond)2024-01-24T00:00:002024Impact of polygenic score for BMI on weight loss effectiveness and genome-wide association analysis.2Professor of Medicine, Harvard Medical SchoolProfessor of Medicine, Harvard Medical Schooltrue1Professor of MedicineProfessor of Medicinetrue1Frank Baldino, Jr., Ph.D. Professor of Sleep MedicineFrank Baldino, Jr., Ph.D. Professor of Sleep MedicineAuthorship 1628163438331654Klerman EB, Wright KP, Duffy JF, Scheer FAJL, Chang AM, Czeisler CA, Rajaratnam SMSleep healthA perspective on the Festschrift of Charles A. Czeisler, PhD MD. Sleep Health. 2024 Feb 07.Sleep Health2024-02-07T00:00:002024A perspective on the Festschrift of Charles A. Czeisler, PhD MD.Authorship 1633343738394243Meyer N, Lok R, Schmidt C, Kyle SD, McClung CA, Cajochen C, Scheer FAJL, Jones MW, Chellappa SLProceedings of the National Academy of Sciences of the United States of AmericaThe sleep-circadian interface: A window into mental disorders. Proc Natl Acad Sci U S A. 2024 Feb 27; 121(9):e2214756121.Proc Natl Acad Sci U S A2024-02-23T00:00:002024The sleep-circadian interface: A window into mental disorders.Authorship 1634052238459260Dashti HS, Scheer FAJL, Saxena R, Garaulet MInternational journal of obesity (2005)Publisher Correction: Impact of polygenic score for BMI on weight loss effectiveness and genome-wide association analysis. Int J Obes (Lond). 2024 Mar 08.Int J Obes (Lond)2024-03-08T00:00:002024Publisher Correction: Impact of polygenic score for BMI on weight loss effectiveness and genome-wide association analysis.true1Peter C. Farrell Professor of Sleep MedicinePeter C. Farrell Professor of Sleep Medicinetrue1Adjunct Professor of EpidemiologyAdjunct Professor of EpidemiologyAuthorship 586416Authorship 60462323904684Chang AM, Scheer FA, Czeisler CA, Aeschbach DSleepDirect effects of light on alertness, vigilance, and the waking electroencephalogram in humans depend on prior light history. Sleep. 2013 Aug 01; 36(8):1239-46.Sleep2013-08-01T00:00:002013Direct effects of light on alertness, vigilance, and the waking electroencephalogram in humans depend on prior light history.Authorship 6501392Authorship 6676441Authorship 6506055Authorship 6619834Authorship 667360623357659Wu YH, Ursinus J, Zhou JN, Scheer FA, Ai-Min B, Jockers R, van Heerikhuize J, Swaab DFJournal of affective disordersAlterations of melatonin receptors MT1 and MT2 in the hypothalamic suprachiasmatic nucleus during depression. J Affect Disord. 2013 Jun; 148(2-3):357-67.J Affect Disord2013-01-26T00:00:002013Alterations of melatonin receptors MT1 and MT2 in the hypothalamic suprachiasmatic nucleus during depression.23863985Hu K, Harper DG, Shea SA, Stopa EG, Scheer FAScientific reportsNoninvasive fractal biomarker of clock neurotransmitter disturbance in humans with dementia. Sci Rep. 2013; 3:2229.Sci Rep2013-01-01T00:00:002013Noninvasive fractal biomarker of clock neurotransmitter disturbance in humans with dementia.23357955Garaulet M, Gómez-Abellán P, Alburquerque-Béjar JJ, Lee YC, Ordovás JM, Scheer FAInternational journal of obesity (2005)Timing of food intake predicts weight loss effectiveness. Int J Obes (Lond). 2013 Apr; 37(4):604-11.Int J Obes (Lond)2013-01-29T00:00:002013Timing of food intake predicts weight loss effectiveness.23535155Morris CJ, Hastings JA, Boyd K, Krainski F, Perhonen MA, Scheer FA, Levine BDAmerican journal of hypertensionDay/night variability in blood pressure: influence of posture and physical activity. Am J Hypertens. 2013 Jun; 26(6):822-8.Am J Hypertens2013-03-27T00:00:002013Day/night variability in blood pressure: influence of posture and physical activity.23456944Scheer FA, Morris CJ, Shea SAObesity (Silver Spring, Md.)The internal circadian clock increases hunger and appetite in the evening independent of food intake and other behaviors. Obesity (Silver Spring). 2013 Mar; 21(3):421-3.Obesity (Silver Spring)2013-03-01T00:00:002013The internal circadian clock increases hunger and appetite in the evening independent of food intake and other behaviors.Authorship 679591223573942Pittman-Polletta BR, Scheer FA, Butler MP, Shea SA, Hu KBiological reviews of the Cambridge Philosophical SocietyThe role of the circadian system in fractal neurophysiological control. Biol Rev Camb Philos Soc. 2013 Nov; 88(4):873-94.Biol Rev Camb Philos Soc2013-04-10T00:00:002013The role of the circadian system in fractal neurophysiological control.Authorship 6819817Authorship 681982623871470Lane JM, Tare A, Cade BE, Chen TH, Punjabi NM, Gottlieb DJ, Scheer FA, Redline S, Saxena RBiological psychiatryCommon variants in CLOCK are not associated with measures of sleep duration in people of european ancestry from the sleep heart health study. Biol Psychiatry. 2013 Dec 15; 74(12):e33-5.Biol Psychiatry2013-07-17T00:00:002013Common variants in CLOCK are not associated with measures of sleep duration in people of european ancestry from the sleep heart health study.Authorship 7017091124280871Tare A, Lane JM, Cade BE, Grant SF, Chen TH, Punjabi NM, Lauderdale DS, Zee PC, Gharib SA, Gottlieb DJ, Scheer FA, Redline S, Saxena RDiabetologiaSleep duration does not mediate or modify association of common genetic variants with type 2 diabetes. Diabetologia. 2014 Feb; 57(2):339-46.Diabetologia2013-11-27T00:00:002013Sleep duration does not mediate or modify association of common genetic variants with type 2 diabetes.Authorship 703918124200683Scheer FA, Shea SABloodHuman circadian system causes a morning peak in prothrombotic plasminogen activator inhibitor-1 (PAI-1) independent of the sleep/wake cycle. Blood. 2014 Jan 23; 123(4):590-3.Blood2013-11-07T00:00:002013Human circadian system causes a morning peak in prothrombotic plasminogen activator inhibitor-1 (PAI-1) independent of the sleep/wake cycle.Authorship 2420232Authorship 617434Authorship 4662611Authorship 725123424583038Buijs FN, Cazarez F, Basualdo MC, Scheer FA, Perusquía M, Centurion D, Buijs RMNeuroscienceThe suprachiasmatic nucleus is part of a neural feedback circuit adapting blood pressure response. Neuroscience. 2014 Apr 25; 266:197-207.Neuroscience2014-02-26T00:00:002014The suprachiasmatic nucleus is part of a neural feedback circuit adapting blood pressure response.Authorship 729086724829282Hsieh WH, Escobar C, Yugay T, Lo MT, Pittman-Polletta B, Salgado-Delgado R, Scheer FA, Shea SA, Buijs RM, Hu KJournal of the Royal Society, InterfaceSimulated shift work in rats perturbs multiscale regulation of locomotor activity. J R Soc Interface. 2014 Jul 06; 11(96).J R Soc Interface2014-07-06T00:00:002014Simulated shift work in rats perturbs multiscale regulation of locomotor activity.Authorship 2347502Authorship 740834224937041Nedeltcheva AV, Scheer FACurrent opinion in endocrinology, diabetes, and obesityMetabolic effects of sleep disruption, links to obesity and diabetes. Curr Opin Endocrinol Diabetes Obes. 2014 Aug; 21(4):293-8.Curr Opin Endocrinol Diabetes Obes2014-08-01T00:00:002014Metabolic effects of sleep disruption, links to obesity and diabetes.Authorship 4051621Authorship 756018225197811Rubio-Sastre P, Scheer FA, Gómez-Abellán P, Madrid JA, Garaulet MSleepAcute melatonin administration in humans impairs glucose tolerance in both the morning and evening. Sleep. 2014 Oct 01; 37(10):1715-9.Sleep2014-10-01T00:00:002014Acute melatonin administration in humans impairs glucose tolerance in both the morning and evening.Authorship 3737104Authorship 7710721025404320Mattson MP, Allison DB, Fontana L, Harvie M, Longo VD, Malaisse WJ, Mosley M, Notterpek L, Ravussin E, Scheer FA, Seyfried TN, Varady KA, Panda SProceedings of the National Academy of Sciences of the United States of AmericaMeal frequency and timing in health and disease. Proc Natl Acad Sci U S A. 2014 Nov 25; 111(47):16647-53.Proc Natl Acad Sci U S A2014-11-17T00:00:002014Meal frequency and timing in health and disease.Authorship 493221Authorship 7779381225527757Dashti HS, Follis JL, Smith CE, Tanaka T, Cade BE, Gottlieb DJ, Hruby A, Jacques PF, Lamon-Fava S, Richardson K, Saxena R, Scheer FA, Kovanen L, Bartz TM, Perälä MM, Jonsson A, Frazier-Wood AC, Kalafati IP, Mikkilä V, Partonen T, Lemaitre RN, Lahti J, Hernandez DG, Toft U, Johnson WC, Kanoni S, Raitakari OT, Perola M, Psaty BM, Ferrucci L, Grarup N, Highland HM, Rallidis L, Kähönen M, Havulinna AS, Siscovick DS, Räikkönen K, Jørgensen T, Rotter JI, Deloukas P, Viikari JS, Mozaffarian D, Linneberg A, Seppälä I, Hansen T, Salomaa V, Gharib SA, Eriksson JG, Bandinelli S, Pedersen O, Rich SS, Dedoussis G, Lehtimäki T, Ordovás JMThe American journal of clinical nutritionHabitual sleep duration is associated with BMI and macronutrient intake and may be modified by CLOCK genetic variants. Am J Clin Nutr. 2015 Jan; 101(1):135-43.Am J Clin Nutr2014-11-26T00:00:002014Habitual sleep duration is associated with BMI and macronutrient intake and may be modified by CLOCK genetic variants.Authorship 589554Authorship 589609Authorship 589904Authorship 586241Authorship 611101Authorship 213113Authorship 4325073Authorship 4713849Authorship 3544301Authorship 588076Authorship 597770Authorship 583415Authorship 1879681Authorship 609770Authorship 592693Authorship 627930Authorship 965432Authorship 2726004Authorship 2525981Authorship 3200392Authorship 3731381Authorship 3787273Authorship 431430125452149Rahman SA, Castanon-Cervantes O, Scheer FA, Shea SA, Czeisler CA, Davidson AJ, Lockley SWBrain, behavior, and immunityEndogenous circadian regulation of pro-inflammatory cytokines and chemokines in the presence of bacterial lipopolysaccharide in humans. Brain Behav Immun. 2015 Jul; 47:4-13.Brain Behav Immun2014-11-13T00:00:002014Endogenous circadian regulation of pro-inflammatory cytokines and chemokines in the presence of bacterial lipopolysaccharide in humans.Authorship 5027722Authorship 8071029Authorship 7890394Authorship 796045225870289Morris CJ, Yang JN, Garcia JI, Myers S, Bozzi I, Wang W, Buxton OM, Shea SA, Scheer FAProceedings of the National Academy of Sciences of the United States of AmericaEndogenous circadian system and circadian misalignment impact glucose tolerance via separate mechanisms in humans. Proc Natl Acad Sci U S A. 2015 Apr 28; 112(17):E2225-34.Proc Natl Acad Sci U S A2015-04-13T00:00:002015Endogenous circadian system and circadian misalignment impact glucose tolerance via separate mechanisms in humans.25311083Bandín C, Scheer FA, Luque AJ, Ávila-Gandía V, Zamora S, Madrid JA, Gómez-Abellán P, Garaulet MInternational journal of obesity (2005)Meal timing affects glucose tolerance, substrate oxidation and circadian-related variables: A randomized, crossover trial. Int J Obes (Lond). 2015 May; 39(5):828-33.Int J Obes (Lond)2014-10-14T00:00:002014Meal timing affects glucose tolerance, substrate oxidation and circadian-related variables: A randomized, crossover trial.25675516Gu C, Coomans CP, Hu K, Scheer FA, Stanley HE, Meijer JHProceedings of the National Academy of Sciences of the United States of AmericaLack of exercise leads to significant and reversible loss of scale invariance in both aged and young mice. Proc Natl Acad Sci U S A. 2015 Feb 24; 112(8):2320-4.Proc Natl Acad Sci U S A2015-02-09T00:00:002015Lack of exercise leads to significant and reversible loss of scale invariance in both aged and young mice.Authorship 3131723Authorship 2667062Authorship 513931Authorship 8107483Authorship 8172941126084345Dashti HS, Follis JL, Smith CE, Tanaka T, Garaulet M, Gottlieb DJ, Hruby A, Jacques PF, Kiefte-de Jong JC, Lamon-Fava S, Scheer FA, Bartz TM, Kovanen L, Wojczynski MK, Frazier-Wood AC, Ahluwalia TS, Perälä MM, Jonsson A, Muka T, Kalafati IP, Mikkilä V, Ordovás JMDiabetes careGene-Environment Interactions of Circadian-Related Genes for Cardiometabolic Traits. Diabetes Care. 2015 Aug; 38(8):1456-66.Diabetes Care2015-06-17T00:00:002015Gene-Environment Interactions of Circadian-Related Genes for Cardiometabolic Traits.Authorship 3545441Authorship 820305225773686Burke TM, Scheer FAJL, Ronda JM, Czeisler CA, Wright KPJournal of sleep researchSleep inertia, sleep homeostatic and circadian influences on higher-order cognitive functions. J Sleep Res. 2015 Aug; 24(4):364-371.J Sleep Res2015-03-13T00:00:002015Sleep inertia, sleep homeostatic and circadian influences on higher-order cognitive functions.Authorship 5178411Authorship 582486Authorship 611492Harvard Medical School2014Nominated for the 2013-2014 Harold Amos Faculty Diversity Award, Harvard Medical SchoolHarvard Medical School2015Nominated for 2014-2015 A. Clifford Barger Excellence in Mentoring Award, Harvard Medical SchoolAuthorship 837436626414564Morris CJ, Garcia JI, Myers S, Yang JN, Trienekens N, Scheer FAObesity (Silver Spring, Md.)The Human Circadian System Has a Dominating Role in Causing the Morning/Evening Difference in Diet-Induced Thermogenesis. Obesity (Silver Spring). 2015 Oct; 23(10):2053-8.Obesity (Silver Spring)2015-10-01T00:00:002015The Human Circadian System Has a Dominating Role in Causing the Morning/Evening Difference in Diet-Induced Thermogenesis.JQ33JingyiQianJingyi Qian, Ph.D.143336Qian, JingyiAssistant Professor of Medicine26440713Garaulet M, Gómez-Abellán P, Rubio-Sastre P, Madrid JA, Saxena R, Scheer FAMetabolism: clinical and experimentalCommon type 2 diabetes risk variant in MTNR1B worsens the deleterious effect of melatonin on glucose tolerance in humans. Metabolism. 2015 Dec; 64(12):1650-7.Metabolism2015-08-14T00:00:002015Common type 2 diabetes risk variant in MTNR1B worsens the deleterious effect of melatonin on glucose tolerance in humans.Authorship 8496546Authorship 847102226567190Dashti HS, Scheer FA, Jacques PF, Lamon-Fava S, Ordovás JMAdvances in nutrition (Bethesda, Md.)Short sleep duration and dietary intake: epidemiologic evidence, mechanisms, and health implications. Adv Nutr. 2015 Nov; 6(6):648-59.Adv Nutr2015-11-13T00:00:002015Short sleep duration and dietary intake: epidemiologic evidence, mechanisms, and health implications.Authorship 4237771Authorship 85237123Authorship 854535326045533Dashti HS, Aslibekyan S, Scheer FA, Smith CE, Lamon-Fava S, Jacques P, Lai CQ, Tucker KL, Arnett DK, Ordovás JMAmerican journal of hypertensionClock Genes Explain a Large Proportion of Phenotypic Variance in Systolic Blood Pressure and This Control Is Not Modified by Environmental Temperature. Am J Hypertens. 2016 Jan; 29(1):132-40.Am J Hypertens2015-06-04T00:00:002015Clock Genes Explain a Large Proportion of Phenotypic Variance in Systolic Blood Pressure and This Control Is Not Modified by Environmental Temperature.26564131Arble DM, Bass J, Behn CD, Butler MP, Challet E, Czeisler C, Depner CM, Elmquist J, Franken P, Grandner MA, Hanlon EC, Keene AC, Joyner MJ, Karatsoreos I, Kern PA, Klein S, Morris CJ, Pack AI, Panda S, Ptacek LJ, Punjabi NM, Sassone-Corsi P, Scheer FA, Saxena R, Seaquest ER, Thimgan MS, Van Cauter E, Wright KPSleepImpact of Sleep and Circadian Disruption on Energy Balance and Diabetes: A Summary of Workshop Discussions. Sleep. 2015 Dec 01; 38(12):1849-60.Sleep2015-12-01T00:00:002015Impact of Sleep and Circadian Disruption on Energy Balance and Diabetes: A Summary of Workshop Discussions.Authorship 624452Authorship 8639254Authorship 8681774Authorship 8689841226858430Morris CJ, Purvis TE, Hu K, Scheer FAProceedings of the National Academy of Sciences of the United States of AmericaCircadian misalignment increases cardiovascular disease risk factors in humans. Proc Natl Acad Sci U S A. 2016 Mar 08; 113(10):E1402-11.Proc Natl Acad Sci U S A2016-02-08T00:00:002016Circadian misalignment increases cardiovascular disease risk factors in humans.26955885Lane JM, Vlasac I, Anderson SG, Kyle SD, Dixon WG, Bechtold DA, Gill S, Little MA, Luik A, Loudon A, Emsley R, Scheer FA, Lawlor DA, Redline S, Ray DW, Rutter MK, Saxena RNature communicationsGenome-wide association analysis identifies novel loci for chronotype in 100,420 individuals from the UK Biobank. Nat Commun. 2016 Mar 09; 7:10889.Nat Commun2016-03-09T00:00:002016Genome-wide association analysis identifies novel loci for chronotype in 100,420 individuals from the UK Biobank.26771705Morris CJ, Purvis TE, Mistretta J, Scheer FAThe Journal of clinical endocrinology and metabolismEffects of the Internal Circadian System and Circadian Misalignment on Glucose Tolerance in Chronic Shift Workers. J Clin Endocrinol Metab. 2016 Mar; 101(3):1066-74.J Clin Endocrinol Metab2016-01-15T00:00:002016Effects of the Internal Circadian System and Circadian Misalignment on Glucose Tolerance in Chronic Shift Workers.26868293Lane JM, Chang AM, Bjonnes AC, Aeschbach D, Anderson C, Cade BE, Cain SW, Czeisler CA, Gharib SA, Gooley JJ, Gottlieb DJ, Grant SF, Klerman EB, Lauderdale DS, Lockley SW, Munch M, Patel S, Punjabi NM, Rajaratnam SM, Rueger M, St Hilaire MA, Santhi N, Scheuermaier K, Van Reen E, Zee PC, Shea SA, Duffy JF, Buxton OM, Redline S, Scheer FA, Saxena RDiabetesImpact of Common Diabetes Risk Variant in MTNR1B on Sleep, Circadian, and Melatonin Physiology. Diabetes. 2016 06; 65(6):1741-51.Diabetes2016-02-11T00:00:002016Impact of Common Diabetes Risk Variant in MTNR1B on Sleep, Circadian, and Melatonin Physiology.Authorship 8720981Authorship 871724326980824Johnston JD, Ordovás JM, Scheer FA, Turek FWAdvances in nutrition (Bethesda, Md.)Circadian Rhythms, Metabolism, and Chrononutrition in Rodents and Humans. Adv Nutr. 2016 Mar; 7(2):399-406.Adv Nutr2016-03-15T00:00:002016Circadian Rhythms, Metabolism, and Chrononutrition in Rodents and Humans.26856900Scheer FASleepHungry for Sleep: A Role for Endocannabinoids? Sleep. 2016 Mar 01; 39(3):495-6.Sleep2016-03-01T00:00:002016Hungry for Sleep: A Role for Endocannabinoids?Authorship 3523722Authorship 879108227079518Qian J, Scheer FAJLTrends in endocrinology and metabolism: TEMCircadian System and Glucose Metabolism: Implications for Physiology and Disease. Trends Endocrinol Metab. 2016 05; 27(5):282-293.Trends Endocrinol Metab2016-04-11T00:00:002016Circadian System and Glucose Metabolism: Implications for Physiology and Disease.HSD5HassanDashtiHassan Saeed Dashti, Ph.D.147683Dashti, HassanAssistant Professor of AnaesthesiaAuthorship 8816431327089043Chang AM, Bjonnes AC, Aeschbach D, Buxton OM, Gooley JJ, Anderson C, Van Reen E, Cain SW, Czeisler CA, Duffy JF, Lockley SW, Shea SA, Scheer FA, Saxena RChronobiology internationalCircadian gene variants influence sleep and the sleep electroencephalogram in humans. Chronobiol Int. 2016; 33(5):561-73.Chronobiol Int2016-04-18T00:00:002016Circadian gene variants influence sleep and the sleep electroencephalogram in humans.Authorship 88390830Authorship 886658627292543Hu K, Riemersma-van der Lek RF, Patxot M, Li P, Shea SA, Scheer FA, Van Someren EJScientific reportsProgression of Dementia Assessed by Temporal Correlations of Physical Activity: Results From a 3.5-Year, Longitudinal Randomized Controlled Trial. Sci Rep. 2016 06 13; 6:27742.Sci Rep2016-06-13T00:00:002016Progression of Dementia Assessed by Temporal Correlations of Physical Activity: Results From a 3.5-Year, Longitudinal Randomized Controlled Trial.Authorship 563312Assistant Professor1Associate Professor0Full Professor3LecturerAuthorship 619909Authorship 897260726857552Dashti HS, Zuurbier LA, de Jonge E, Voortman T, Jacques PF, Lamon-Fava S, Scheer FA, Kiefte-De Jong JC, Hofman A, Ordovás JM, Franco OH, Tiemeier HJournal of sleep researchActigraphic sleep fragmentation, efficiency and duration associate with dietary intake in the Rotterdam Study. J Sleep Res. 2016 08; 25(4):404-11.J Sleep Res2016-02-09T00:00:002016Actigraphic sleep fragmentation, efficiency and duration associate with dietary intake in the Rotterdam Study.Authorship 599961Authorship 620784Authorship 910615927256623Carrasco-Benso MP, Rivero-Gutierrez B, Lopez-Minguez J, Anzola A, Diez-Noguera A, Madrid JA, Lujan JA, Martínez-Augustin O, Scheer FA, Garaulet MFASEB journal : official publication of the Federation of American Societies for Experimental BiologyHuman adipose tissue expresses intrinsic circadian rhythm in insulin sensitivity. FASEB J. 2016 09; 30(9):3117-23.FASEB J2016-06-02T00:00:002016Human adipose tissue expresses intrinsic circadian rhythm in insulin sensitivity.2015-06-30SCHEER, FRANK A2009-09-01Mechanisms underlying adverse health consequences of shift workR01HL0948062010-06-30SCHEER, FRANK A2005-09-01Melatonin Supplementation in Hypertensive PatientsR21AT0027132020-04-30SCHEER, FRANK A2014-05-15Meal Time Effects on Metabolic Health.R01DK0995122020-03-31SCHEER, FRANK A2014-06-01Development of countermeasures against adverse metabolic effects of shift workR01HL1186012010-03-31GOTTLIEB, GARY L1984-12-01General Clinical Research CenterM01RR0026352021-05-31SCHEER, FRANK A2015-08-19Melatonin and Receptor Gene Variant: Linking Circadian System and Type 2 DiabetesR01DK1026962021-05-31SAXENA, RICHA2016-06-01Impact of Malatonin, Food Timing and Receptor Variant on Type 2 Diabetes RiskR01DK1050722012-08-31SAXENA, RICHA2010-09-10Impact of MTNR1B and CRY2 variants on sleep circadian physiology and metabolismR21DK089378Authorship 610907Principal InvestigatorPrincipal InvestigatorCo-Principal InvestigatorCo-Principal InvestigatorCo-Principal InvestigatorCo-Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorAuthorship 916604427656401van Moorsel D, Hansen J, Havekes B, Scheer FAJL, Jörgensen JA, Hoeks J, Schrauwen-Hinderling VB, Duez H, Lefebvre P, Schaper NC, Hesselink MKC, Staels B, Schrauwen PMolecular metabolismDemonstration of a day-night rhythm in human skeletal muscle oxidative capacity. Mol Metab. 2016 Aug; 5(8):635-645.Mol Metab2016-07-01T00:00:002016Demonstration of a day-night rhythm in human skeletal muscle oxidative capacity.Authorship 602371Authorship 4028661Authorship 583889Authorship 2077451Authorship 94071412Authorship 943433426948400Ruiz-Lozano T, Vidal J, de Hollanda A, Scheer FAJL, Garaulet M, Izquierdo-Pulido MClinical nutrition (Edinburgh, Scotland)Timing of food intake is associated with weight loss evolution in severe obese patients after bariatric surgery. Clin Nutr. 2016 12; 35(6):1308-1314.Clin Nutr2016-02-16T00:00:002016Timing of food intake is associated with weight loss evolution in severe obese patients after bariatric surgery.27992416Lane JM, Liang J, Vlasac I, Anderson SG, Bechtold DA, Bowden J, Emsley R, Gill S, Little MA, Luik AI, Loudon A, Scheer FA, Purcell SM, Kyle SD, Lawlor DA, Zhu X, Redline S, Ray DW, Rutter MK, Saxena RNature geneticsGenome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits. Nat Genet. 2017 Feb; 49(2):274-281.Nat Genet2016-12-19T00:00:002016Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits.Academy of Behavioral Medicine Research2009Neal Miller Award, Academy of Behavioral Medicine ResearchNational Sleep Foundation/Sleep Research Socie20081st Place Clinical Research Young Investigator Award, National Sleep Foundation/Sleep Research SocieEuropean Sleep Research Society2006Alliance Chronosleep Award, European Sleep Research SocietyAmerican Academy of Sleep Medicine2005Young Investigator Neurology Section Award, American Academy of Sleep MedicineEuropean Sleep Research Society2006Finalist Helgi Kristbjarnarson's Award, European Sleep Research SocietyAmerican Academy of Sleep Medicine2007Young Investigator Award, American Academy of Sleep MedicineNational Sleep Foundation20072005Pickwick Postdoctoral Fellowship, National Sleep FoundationSleep Research Society2010Young Investigator Award, Honorable Mention, Sleep Research Society221 Longwood AveBrigham and Womens HospitalDivision of Sleep Medicine221 Longwood AveBoston02115MA10452332Scheer FA, van Doornen LJ, Buijs RMJournal of biological rhythmsLight and diurnal cycle affect human heart rate: possible role for the circadian pacemaker. J Biol Rhythms. 1999 Jun; 14(3):202-12.J Biol Rhythms1999-06-01T00:00:001999Light and diurnal cycle affect human heart rate: possible role for the circadian pacemaker.14732734Scheer FA, Van Montfrans GA, van Someren EJ, Mairuhu G, Buijs RMHypertension (Dallas, Tex. : 1979)Daily nighttime melatonin reduces blood pressure in male patients with essential hypertension. Hypertension. 2004 Feb; 43(2):192-7.Hypertension2004-01-19T00:00:002004Daily nighttime melatonin reduces blood pressure in male patients with essential hypertension.Authorship 970562127529397Scheer F, Spunar P, Wiggermann P, Wissgott C, Andresen RRoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der NuklearmedizinMesenteric Panniculitis (MP) in CT - A Predictor of Malignancy? Rofo. 2016 Oct; 188(10):926-32.Rofo2016-08-16T00:00:002016Mesenteric Panniculitis (MP) in CT - A Predictor of Malignancy?Authorship 9747445Authorship 9740851728346153Ohayon M, Wickwire EM, Hirshkowitz M, Albert SM, Avidan A, Daly FJ, Dauvilliers Y, Ferri R, Fung C, Gozal D, Hazen N, Krystal A, Lichstein K, Mallampalli M, Plazzi G, Rawding R, Scheer FA, Somers V, Vitiello MVSleep healthNational Sleep Foundation's sleep quality recommendations: first report. Sleep Health. 2017 02; 3(1):6-19.Sleep Health2016-12-23T00:00:002016National Sleep Foundation's sleep quality recommendations: first report.28347188Morris CJ, Purvis TE, Mistretta J, Hu K, Scheer FAJLJournal of biological rhythmsCircadian Misalignment Increases C-Reactive Protein and Blood Pressure in Chronic Shift Workers. J Biol Rhythms. 2017 04; 32(2):154-164.J Biol Rhythms2017-03-27T00:00:002017Circadian Misalignment Increases C-Reactive Protein and Blood Pressure in Chronic Shift Workers.10487717Scheer FA, Buijs RMThe Journal of clinical endocrinology and metabolismLight affects morning salivary cortisol in humans. J Clin Endocrinol Metab. 1999 Sep; 84(9):3395-8.J Clin Endocrinol Metab1999-09-01T00:00:001999Light affects morning salivary cortisol in humans.12419485Scheer FA, Van Paassen B, Van Montfrans GA, Fliers E, Van Someren EJ, Van Heerikhuize JJ, Buijs RMNeuroscience lettersHuman basal cortisol levels are increased in hospital compared to home setting. Neurosci Lett. 2002 Nov 22; 333(2):79-82.Neurosci Lett2002-11-22T00:00:002002Human basal cortisol levels are increased in hospital compared to home setting.17107936Kalsbeek A, Palm IF, La Fleur SE, Scheer FA, Perreau-Lenz S, Ruiter M, Kreier F, Cailotto C, Buijs RMJournal of biological rhythmsSCN outputs and the hypothalamic balance of life. J Biol Rhythms. 2006 Dec; 21(6):458-69.J Biol Rhythms2006-12-01T00:00:002006SCN outputs and the hypothalamic balance of life.17533214Scheer FA, Stone PH, Shea SAArchives of internal medicineDecreased sleep in heart failure: are medications to blame? Arch Intern Med. 2007 May 28; 167(10):1098-9; author reply 1099-100.Arch Intern Med2007-05-28T00:00:002007Decreased sleep in heart failure: are medications to blame?17684566Scheer FA, Wright KP, Kronauer RE, Czeisler CAPloS onePlasticity of the intrinsic period of the human circadian timing system. PLoS One. 2007 Aug 08; 2(8):e721.PLoS One2007-08-08T00:00:002007Plasticity of the intrinsic period of the human circadian timing system.11179089Scheer FA, Ter Horst GJ, van Der Vliet J, Buijs RMAmerican journal of physiology. Heart and circulatory physiologyPhysiological and anatomic evidence for regulation of the heart by suprachiasmatic nucleus in rats. Am J Physiol Heart Circ Physiol. 2001 Mar; 280(3):H1391-9.Am J Physiol Heart Circ Physiol2001-03-01T00:00:002001Physiological and anatomic evidence for regulation of the heart by suprachiasmatic nucleus in rats.21931750Scheer FA, Michelson AD, Frelinger AL, Evoniuk H, Kelly EE, McCarthy M, Doamekpor LA, Barnard MR, Shea SAPloS oneThe human endogenous circadian system causes greatest platelet activation during the biological morning independent of behaviors. PLoS One. 2011; 6(9):e24549.PLoS One2011-09-08T00:00:002011The human endogenous circadian system causes greatest platelet activation during the biological morning independent of behaviors.21939733Morris CJ, Aeschbach D, Scheer FAMolecular and cellular endocrinologyCircadian system, sleep and endocrinology. Mol Cell Endocrinol. 2012 Feb 05; 349(1):91-104.Mol Cell Endocrinol2011-09-10T00:00:002011Circadian system, sleep and endocrinology.Shea SA, Hilton MF, Scheer FA, Ayers R, Evoniuk HL, Shiels SA, Sugarbaker RJ, Malhotra A, Massaro AF.SleepAn endogenous circadian rhythm in bronchodilator rescue medication use in asthma. Sleep. 2004; 27:A81.2004-01-01T00:00:002004An endogenous circadian rhythm in bronchodilator rescue medication use in asthma14766324Scheer FA, Van Doornen LJ, Buijs RMAutonomic neuroscience : basic & clinicalLight and diurnal cycle affect autonomic cardiac balance in human; possible role for the biological clock. Auton Neurosci. 2004 Jan 30; 110(1):44-8.Auton Neurosci2004-01-30T00:00:002004Light and diurnal cycle affect autonomic cardiac balance in human; possible role for the biological clock.15802197Scheer FA, Pirovano C, Van Someren EJ, Buijs RMNeuroscienceEnvironmental light and suprachiasmatic nucleus interact in the regulation of body temperature. Neuroscience. 2005; 132(2):465-77.Neuroscience2005-01-01T00:00:002005Environmental light and suprachiasmatic nucleus interact in the regulation of body temperature.15649734Scheer FA, Czeisler CASleep medicine reviewsMelatonin, sleep, and circadian rhythms. Sleep Med Rev. 2005 Feb; 9(1):5-9.Sleep Med Rev2005-02-01T00:00:002005Melatonin, sleep, and circadian rhythms.22405069Jeyaraj D, Scheer FA, Ripperger JA, Haldar SM, Lu Y, Prosdocimo DA, Eapen SJ, Eapen BL, Cui Y, Mahabeleshwar GH, Lee HG, Smith MA, Casadesus G, Mintz EM, Sun H, Wang Y, Ramsey KM, Bass J, Shea SA, Albrecht U, Jain MKCell metabolismKlf15 orchestrates circadian nitrogen homeostasis. Cell Metab. 2012 Mar 07; 15(3):311-23.Cell Metab2012-03-07T00:00:002012Klf15 orchestrates circadian nitrogen homeostasis.12817466Scheer FA, Kalsbeek A, Buijs RMBiological chemistryCardiovascular control by the suprachiasmatic nucleus: neural and neuroendocrine mechanisms in human and rat. Biol Chem. 2003 May; 384(5):697-709.Biol Chem2003-05-01T00:00:002003Cardiovascular control by the suprachiasmatic nucleus: neural and neuroendocrine mechanisms in human and rat.Frank A.J.L. Scheer, Thomas J. Shea, Heather L. Evoniuk, Michael F. HiltonJ Sleep ResCircadian Rhythm in Degree of Sleep Inertia Following Awakening. J Sleep Res. 2006; 15(1):55.2006-01-01T00:00:002006Circadian Rhythm in Degree of Sleep Inertia Following AwakeningJung CM, Khalsa S, Scheer FA, Czeisler CA, Wright KP.SleepAcute effects of bright light exposure on nighttime cortisol levels in humans. Sleep. 2005; 28:A59.2005-01-01T00:00:002005Acute effects of bright light exposure on nighttime cortisol levels in humansAuthorship 996394228697366Vetter C, Scheer FAJLCurrent biology : CBCircadian Biology: Uncoupling Human Body Clocks by Food Timing. Curr Biol. 2017 07 10; 27(13):R656-R658.Curr Biol2017-07-10T00:00:002017Circadian Biology: Uncoupling Human Body Clocks by Food Timing.17920204Hu K, Scheer FA, Ivanov PCh, Buijs RM, Shea SANeuroscienceThe suprachiasmatic nucleus functions beyond circadian rhythm generation. Neuroscience. 2007 Nov 09; 149(3):508-17.Neuroscience2007-10-24T00:00:002007The suprachiasmatic nucleus functions beyond circadian rhythm generation.16876585Buijs RM, Scheer FA, Kreier F, Yi C, Bos N, Goncharuk VD, Kalsbeek AProgress in brain researchOrganization of circadian functions: interaction with the body. Prog Brain Res. 2006; 153:341-60.Prog Brain Res2006-01-01T00:00:002006Organization of circadian functions: interaction with the body.21414317Kalsbeek A, Scheer FA, Perreau-Lenz S, La Fleur SE, Yi CX, Fliers E, Buijs RMFEBS lettersCircadian disruption and SCN control of energy metabolism. FEBS Lett. 2011 May 20; 585(10):1412-26.FEBS Lett2011-03-21T00:00:002011Circadian disruption and SCN control of energy metabolism.Authorship 10061977Authorship 10032174Authorship 10067951128736443Lo MT, Bandin C, Yang HW, Scheer FAJL, Hu K, Garaulet MInternational journal of obesity (2005)CLOCK 3111T/C genetic variant influences the daily rhythm of autonomic nervous function: relevance to body weight control. Int J Obes (Lond). 2018 02; 42(2):190-197.Int J Obes (Lond)2017-07-24T00:00:002017CLOCK 3111T/C genetic variant influences the daily rhythm of autonomic nervous function: relevance to body weight control.28838129Li P, Morris CJ, Patxot M, Yugay T, Mistretta J, Purvis TE, Scheer FAJL, Hu KSleepReduced Tolerance to Night Shift in Chronic Shift Workers: Insight From Fractal Regulation. Sleep. 2017 07 01; 40(7).Sleep2017-07-01T00:00:002017Reduced Tolerance to Night Shift in Chronic Shift Workers: Insight From Fractal Regulation.28842526Dashti HS, Follis JL, Smith CE, Tanaka T, Garaulet M, Gottlieb DJ, Hruby A, Jacques PF, Kiefte-de Jong JC, Lamon-Fava S, Scheer FAJL, Bartz TM, Kovanen L, Wojczynski MK, Frazier-Wood AC, Ahluwalia TS, Perälä MM, Jonsson A, Muka T, Kalafati IP, Mikkilä V, Ordovás JMDiabetes careErratum. Gene-Environment Interactions of Circadian-Related Genes for Cardiometabolic Traits. Diabetes Care 2015;38:1456-1466. Diabetes Care. 2017 10; 40(10):1420.Diabetes Care2017-08-25T00:00:002017Erratum. Gene-Environment Interactions of Circadian-Related Genes for Cardiometabolic Traits. Diabetes Care 2015;38:1456-1466.Authorship 1008795828877894McHill AW, Phillips AJ, Czeisler CA, Keating L, Yee K, Barger LK, Garaulet M, Scheer FA, Klerman EBThe American journal of clinical nutritionLater circadian timing of food intake is associated with increased body fat. Am J Clin Nutr. 2017 Nov; 106(5):1213-1219.Am J Clin Nutr2017-09-06T00:00:002017Later circadian timing of food intake is associated with increased body fat.2023-05-31SCHEER, FRANK A2017-09-15Role of Meal Timing in Efficacy of Bariatric Surgery in Obese IndividualsR01HL140574Co-Principal InvestigatorThe major goals of this project are to determine whether the temporal distribution of macronutrient intake will affect metabolism in humans.20161149Litinski M, Scheer FA, Shea SASleep medicine clinicsInfluence of the Circadian System on Disease Severity. Sleep Med Clin. 2009 Jun 01; 4(2):143-163.Sleep Med Clin2009-06-01T00:00:002009Influence of the Circadian System on Disease Severity.Authorship 1018861428455106Lopez-Minguez J, Saxena R, Bandín C, Scheer FA, Garaulet MClinical nutrition (Edinburgh, Scotland)Late dinner impairs glucose tolerance in MTNR1B risk allele carriers: A randomized, cross-over study. Clin Nutr. 2018 08; 37(4):1133-1140.Clin Nutr2017-04-10T00:00:002017Late dinner impairs glucose tolerance in MTNR1B risk allele carriers: A randomized, cross-over study.16130027Scheer FA, Zeitzer JM, Ayas NT, Brown R, Czeisler CA, Shea SASpinal cordReduced sleep efficiency in cervical spinal cord injury; association with abolished night time melatonin secretion. Spinal Cord. 2006 Feb; 44(2):78-81.Spinal Cord2006-02-01T00:00:002006Reduced sleep efficiency in cervical spinal cord injury; association with abolished night time melatonin secretion.18663242Scheer FA, Shea TJ, Hilton MF, Shea SAJournal of biological rhythmsAn endogenous circadian rhythm in sleep inertia results in greatest cognitive impairment upon awakening during the biological night. J Biol Rhythms. 2008 Aug; 23(4):353-61.J Biol Rhythms2008-08-01T00:00:002008An endogenous circadian rhythm in sleep inertia results in greatest cognitive impairment upon awakening during the biological night.21224217Chang AM, Scheer FA, Czeisler CAThe Journal of physiologyThe human circadian system adapts to prior photic history. J Physiol. 2011 Mar 01; 589(Pt 5):1095-102.J Physiol2011-01-10T00:00:002011The human circadian system adapts to prior photic history.Scheer FAJL.J Sleep ResSuprachiasmatic nucleus, environmental light, and metabolic state interact in the regulation of body temperature. J Sleep Res. 2006; 20.2006-01-01T00:00:002006Suprachiasmatic nucleus, environmental light, and metabolic state interact in the regulation of body temperatureKun Hu, Frank A.J.L. Scheer, Plamen Ch. Ivanov, Ruud M. Buijs, Steven A. SheaSleepIntrinsic scale-invariant patterns of locomotor activity: role of the circadian pacemaker across a wide range of time scales – spanning 4-24 hours. Sleep. 2006; 29:A64.2006-01-01T00:00:002006Intrinsic scale-invariant patterns of locomotor activity: role of the circadian pacemaker across a wide range of time scales – spanning 4-24 hoursAuthorship 1029597729182371Joustra SD, Gu C, Rohling JHT, Pickering L, Klose M, Hu K, Scheer FA, Feldt-Rasmussen U, Jennum PJ, Pereira AM, Biermasz NR, Meijer JHChronobiology internationalDecrease in scale invariance of activity fluctuations with aging and in patients with suprasellar tumors. Chronobiol Int. 2018 03; 35(3):368-377.Chronobiol Int2017-11-28T00:00:002017Decrease in scale invariance of activity fluctuations with aging and in patients with suprasellar tumors.16494083Lockley SW, Evans EE, Scheer FA, Brainard GC, Czeisler CA, Aeschbach DSleepShort-wavelength sensitivity for the direct effects of light on alertness, vigilance, and the waking electroencephalogram in humans. Sleep. 2006 Feb; 29(2):161-8.Sleep2006-02-01T00:00:002006Short-wavelength sensitivity for the direct effects of light on alertness, vigilance, and the waking electroencephalogram in humans.Hu K, Scheer FAJL, Buijs RM, Shea SA.SleepEffect of lesioning the suprachiasmatic nucleus on fractal pattern of heart rate fluctuations. Sleep. 2007; 30:A64.2007-01-01T00:00:002007Effect of lesioning the suprachiasmatic nucleus on fractal pattern of heart rate fluctuationsAuthorship 10315319Authorship 1033365829233857Collado MC, Engen PA, Bandín C, Cabrera-Rubio R, Voigt RM, Green SJ, Naqib A, Keshavarzian A, Scheer FAJL, Garaulet MFASEB journal : official publication of the Federation of American Societies for Experimental BiologyTiming of food intake impacts daily rhythms of human salivary microbiota: a randomized, crossover study. FASEB J. 2018 04; 32(4):2060-2072.FASEB J2018-01-05T00:00:002018Timing of food intake impacts daily rhythms of human salivary microbiota: a randomized, crossover study.28460138Tucker MA, Morris CJ, Morgan A, Yang J, Myers S, Pierce JG, Stickgold R, Scheer FAJLSleepThe Relative Impact of Sleep and Circadian Drive on Motor Skill Acquisition and Memory Consolidation. Sleep. 2017 04 01; 40(4).Sleep2017-04-01T00:00:002017The Relative Impact of Sleep and Circadian Drive on Motor Skill Acquisition and Memory Consolidation.21339480Hu K, Scheer FA, Laker M, Smales C, Shea SACirculationEndogenous circadian rhythm in vasovagal response to head-up tilt. Circulation. 2011 Mar 08; 123(9):961-70.Circulation2011-02-21T00:00:002011Endogenous circadian rhythm in vasovagal response to head-up tilt.Scheer FAJL, Wright Jr. KP, Gronfier C, Kronauer RE, Czeisler CASleepHuman circadian period is influenced by entrainment to non-24 hour schedules. Sleep. 2005; 28:A72.2005-01-01T00:00:002005Human circadian period is influenced by entrainment to non-24 hour schedulesAuthorship 1038770629343740Vera B, Dashti HS, Gómez-Abellán P, Hernández-Martínez AM, Esteban A, Scheer FAJL, Saxena R, Garaulet MScientific reportsModifiable lifestyle behaviors, but not a genetic risk score, associate with metabolic syndrome in evening chronotypes. Sci Rep. 2018 01 17; 8(1):945.Sci Rep2018-01-17T00:00:002018Modifiable lifestyle behaviors, but not a genetic risk score, associate with metabolic syndrome in evening chronotypes.Scheer FAJL, Hahn M, Doamekpor LA, Evoniuk H, Kelly K, Laker MD, Shea SA.SleepLack of endogenous circadian rhythm of platelet aggregability. Sleep. 2007; 30:A64.2007-01-01T00:00:002007Lack of endogenous circadian rhythm of platelet aggregability19786369Pavlova MK, Shea SA, Scheer FA, Bromfield EBEpilepsy & behavior : E&BIs there a circadian variation of epileptiform abnormalities in idiopathic generalized epilepsy? Epilepsy Behav. 2009 Nov; 16(3):461-7.Epilepsy Behav2009-09-27T00:00:002009Is there a circadian variation of epileptiform abnormalities in idiopathic generalized epilepsy?Authorship 10057123185285Hu K, Meijer JH, Shea SA, vanderLeest HT, Pittman-Polletta B, Houben T, van Oosterhout F, Deboer T, Scheer FAPloS oneFractal patterns of neural activity exist within the suprachiasmatic nucleus and require extrinsic network interactions. PLoS One. 2012; 7(11):e48927.PLoS One2012-11-20T00:00:002012Fractal patterns of neural activity exist within the suprachiasmatic nucleus and require extrinsic network interactions.29445188Chellappa SL, Morris CJ, Scheer FAJLScientific reportsDaily circadian misalignment impairs human cognitive performance task-dependently. Sci Rep. 2018 02 14; 8(1):3041.Sci Rep2018-02-14T00:00:002018Daily circadian misalignment impairs human cognitive performance task-dependently.Authorship 1010932Thomas J Shea, Michael F Hilton, Heather L Evoniuk, Frank AJL ScheerSleepCircadian Effect on Degree of Sleep Inertia Present After Awakening. Sleep. 2006; 29:A67.2006-01-01T00:00:002006Circadian Effect on Degree of Sleep Inertia Present After Awakening