BDW1BruceWalkerBruce David Walker, M.D.42.37730000000000-71.0525000000000079342Walker, BruceDavid857/268-7072Phillip T. and Susan M. Ragon Professor of Medicinecatalyst:advisorInMentoringCompletedStudentProjectcompleted student projectscatalyst:eCommonsLogineCommons LoginMentoring - Completed Student Projectprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:address2address line 2vivo:address3address line 3vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:middleNamemiddle name or initialvivo:overviewoverviewvivo:personInPositionpositionsvivo:phoneNumberphonePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofvivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson10906229Goulder PJ, Lechner F, Klenerman P, McIntosh K, Walker BDJournal of virologyCharacterization of a novel respiratory syncytial virus-specific human cytotoxic T-lymphocyte epitope. J Virol. 2000 Aug; 74(16):7694-7.J Virol2000-08-01T00:00:002000Characterization of a novel respiratory syncytial virus-specific human cytotoxic T-lymphocyte epitope.11029005Rosenberg ES, Altfeld M, Poon SH, Phillips MN, Wilkes BM, Eldridge RL, Robbins GK, D'Aquila RT, Goulder PJ, Walker BDNatureImmune control of HIV-1 after early treatment of acute infection. Nature. 2000 Sep 28; 407(6803):523-6.Nature2000-09-28T00:00:002000Immune control of HIV-1 after early treatment of acute infection.11559810Norris PJ, Sumaroka M, Brander C, Moffett HF, Boswell SL, Nguyen T, Sykulev Y, Walker BD, Rosenberg ESJournal of virologyMultiple effector functions mediated by human immunodeficiency virus-specific CD4(+) T-cell clones. J Virol. 2001 Oct; 75(20):9771-9.J Virol2001-10-01T00:00:002001Multiple effector functions mediated by human immunodeficiency virus-specific CD4(+) T-cell clones.Authorship 104544312Authorship 10486041329437954Joglekar AV, Liu Z, Weber JK, Ouyang Y, Jeppson JD, Noh WJ, Lamothe-Molina PA, Chen H, Kang SG, Bethune MT, Zhou R, Walker BD, Baltimore DProceedings of the National Academy of Sciences of the United States of AmericaT cell receptors for the HIV KK10 epitope from patients with differential immunologic control are functionally indistinguishable. Proc Natl Acad Sci U S A. 2018 02 20; 115(8):1877-1882.Proc Natl Acad Sci U S A2018-02-07T00:00:002018T cell receptors for the HIV KK10 epitope from patients with differential immunologic control are functionally indistinguishable.29461980Martin MP, Naranbhai V, Shea PR, Qi Y, Ramsuran V, Vince N, Gao X, Thomas R, Brumme ZL, Carlson JM, Wolinsky SM, Goedert JJ, Walker BD, Segal FP, Deeks SG, Haas DW, Migueles SA, Connors M, Michael N, Fellay J, Gostick E, Llewellyn-Lacey S, Price DA, Lafont BA, Pymm P, Saunders PM, Widjaja J, Wong SC, Vivian JP, Rossjohn J, Brooks AG, Carrington MThe Journal of clinical investigationKiller cell immunoglobulin-like receptor 3DL1 variation modifies HLA-B*57 protection against HIV-1. J Clin Invest. 2018 05 01; 128(5):1903-1912.J Clin Invest2018-04-03T00:00:002018Killer cell immunoglobulin-like receptor 3DL1 variation modifies HLA-B*57 protection against HIV-1.11017132Walker BD, Rosenberg ESNature medicineContaining HIV after infection. Nat Med. 2000 Oct; 6(10):1094-5.Nat Med2000-10-01T00:00:002000Containing HIV after infection.11424007Brander C, O'Connor P, Suscovich T, Jones NG, Lee Y, Kedes D, Ganem D, Martin J, Osmond D, Southwood S, Sette A, Walker BD, Scadden DTThe Journal of infectious diseasesDefinition of an optimal cytotoxic T lymphocyte epitope in the latently expressed Kaposi's sarcoma-associated herpesvirus kaposin protein. J Infect Dis. 2001 Jul 15; 184(2):119-26.J Infect Dis2001-06-18T00:00:002001Definition of an optimal cytotoxic T lymphocyte epitope in the latently expressed Kaposi's sarcoma-associated herpesvirus kaposin protein.12163589Yu XG, Addo MM, Rosenberg ES, Rodriguez WR, Lee PK, Fitzpatrick CA, Johnston MN, Strick D, Goulder PJ, Walker BD, Altfeld MJournal of virologyConsistent patterns in the development and immunodominance of human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T-cell responses following acute HIV-1 infection. J Virol. 2002 Sep; 76(17):8690-701.J Virol2002-09-01T00:00:002002Consistent patterns in the development and immunodominance of human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T-cell responses following acute HIV-1 infection.Authorship 10520251629515029Cheng HD, Grimm SK, Gilman MS, Gwom LC, Sok D, Sundling C, Donofrio G, Karlsson Hedestam GB, Bonsignori M, Haynes BF, Lahey TP, Maro I, von Reyn CF, Gorny MK, Zolla-Pazner S, Walker BD, Alter G, Burton DR, Robb ML, Krebs SJ, Seaman MS, Bailey-Kellogg C, Ackerman MEJCI insightFine epitope signature of antibody neutralization breadth at the HIV-1 envelope CD4-binding site. JCI Insight. 2018 03 08; 3(5).JCI Insight2018-03-08T00:00:002018Fine epitope signature of antibody neutralization breadth at the HIV-1 envelope CD4-binding site.14685052Altfeld M, Addo MM, Rosenberg ES, Hecht FM, Lee PK, Vogel M, Yu XG, Draenert R, Johnston MN, Strick D, Allen TM, Feeney ME, Kahn JO, Sekaly RP, Levy JA, Rockstroh JK, Goulder PJ, Walker BDAIDS (London, England)Influence of HLA-B57 on clinical presentation and viral control during acute HIV-1 infection. AIDS. 2003 Dec 05; 17(18):2581-91.AIDS2003-12-05T00:00:002003Influence of HLA-B57 on clinical presentation and viral control during acute HIV-1 infection.15194783Allen TM, Altfeld M, Yu XG, O'Sullivan KM, Lichterfeld M, Le Gall S, John M, Mothe BR, Lee PK, Kalife ET, Cohen DE, Freedberg KA, Strick DA, Johnston MN, Sette A, Rosenberg ES, Mallal SA, Goulder PJ, Brander C, Walker BDJournal of virologySelection, transmission, and reversion of an antigen-processing cytotoxic T-lymphocyte escape mutation in human immunodeficiency virus type 1 infection. J Virol. 2004 Jul; 78(13):7069-78.J Virol2004-07-01T00:00:002004Selection, transmission, and reversion of an antigen-processing cytotoxic T-lymphocyte escape mutation in human immunodeficiency virus type 1 infection.15360006Suscovich TJ, Paulose-Murphy M, Harlow JD, Chen Y, Thomas SY, Mellott TJ, Walker BD, Scadden DT, Zeichner S, Brander CLeukemia & lymphomaDefective immune function of primary effusion lymphoma cells is associated with distinct KSHV gene expression profiles. Leuk Lymphoma. 2004 Jun; 45(6):1223-38.Leuk Lymphoma2004-06-01T00:00:002004Defective immune function of primary effusion lymphoma cells is associated with distinct KSHV gene expression profiles.19327049Rousseau CM, Lockhart DW, Listgarten J, Maley SN, Kadie C, Learn GH, Nickle DC, Heckerman DE, Deng W, Brander C, Ndung'u T, Coovadia H, Goulder PJ, Korber BT, Walker BD, Mullins JIAIDS research and human retrovirusesRare HLA drive additional HIV evolution compared to more frequent alleles. AIDS Res Hum Retroviruses. 2009 Mar; 25(3):297-303.AIDS Res Hum Retroviruses2009-03-01T00:00:002009Rare HLA drive additional HIV evolution compared to more frequent alleles.Authorship 1055364729581149Alter G, Dowell KG, Brown EP, Suscovich TJ, Mikhailova A, Mahan AE, Walker BD, Nimmerjahn F, Bailey-Kellogg C, Ackerman MEMolecular systems biologyHigh-resolution definition of humoral immune response correlates of effective immunity against HIV. Mol Syst Biol. 2018 03 26; 14(3):e7881.Mol Syst Biol2018-03-26T00:00:002018High-resolution definition of humoral immune response correlates of effective immunity against HIV.Authorship 1033628Authorship 103697118084001Delwart EL, Sheppard HW, Walker BD, Goudsmit J, Mullins JIJournal of virologyHuman immunodeficiency virus type 1 evolution in vivo tracked by DNA heteroduplex mobility assays. J Virol. 1994 Oct; 68(10):6672-83.J Virol1994-10-01T00:00:001994Human immunodeficiency virus type 1 evolution in vivo tracked by DNA heteroduplex mobility assays.9495345Wagner L, Yang OO, Garcia-Zepeda EA, Ge Y, Kalams SA, Walker BD, Pasternack MS, Luster ADNatureBeta-chemokines are released from HIV-1-specific cytolytic T-cell granules complexed to proteoglycans. Nature. 1998 Feb 26; 391(6670):908-11.Nature1998-02-26T00:00:001998Beta-chemokines are released from HIV-1-specific cytolytic T-cell granules complexed to proteoglycans.Authorship 1018341010196293Wilson CC, Brown RC, Korber BT, Wilkes BM, Ruhl DJ, Sakamoto D, Kunstman K, Luzuriaga K, Hanson IC, Widmayer SM, Wiznia A, Clapp S, Ammann AJ, Koup RA, Wolinsky SM, Walker BDJournal of virologyFrequent detection of escape from cytotoxic T-lymphocyte recognition in perinatal human immunodeficiency virus (HIV) type 1 transmission: the ariel project for the prevention of transmission of HIV from mother to infant. J Virol. 1999 May; 73(5):3975-85.J Virol1999-05-01T00:00:001999Frequent detection of escape from cytotoxic T-lymphocyte recognition in perinatal human immunodeficiency virus (HIV) type 1 transmission: the ariel project for the prevention of transmission of HIV from mother to infant.29620716Chung AW, Mabuka JM, Ndlovu B, Licht A, Robinson H, Ramlakhan Y, Ghebremichael M, Reddy T, Goulder PJR, Walker BD, Ndung'u T, Alter GAIDS (London, England)Viral control in chronic HIV-1 subtype C infection is associated with enrichment of p24 IgG1 with Fc effector activity. AIDS. 2018 06 19; 32(10):1207-1217.AIDS2018-06-19T00:00:002018Viral control in chronic HIV-1 subtype C infection is associated with enrichment of p24 IgG1 with Fc effector activity.10843537Mani I, Cao H, Hom D, Johnson JL, Mugerwa RD, Travers KU, Caliendo AM, Walker BD, Kanki PJJournal of acquired immune deficiency syndromes (1999)Plasma RNA viral load as measured by the branched DNA and nucleic acid sequence-based amplification assays of HIV-1 subtypes A and D in Uganda. J Acquir Immune Defic Syndr. 1999 Oct 01; 22(2):208-9.J Acquir Immune Defic Syndr1999-10-01T00:00:001999Plasma RNA viral load as measured by the branched DNA and nucleic acid sequence-based amplification assays of HIV-1 subtypes A and D in Uganda.10925292Brander C, Suscovich T, Lee Y, Nguyen PT, O'Connor P, Seebach J, Jones NG, van Gorder M, Walker BD, Scadden DTJournal of immunology (Baltimore, Md. : 1950)Impaired CTL recognition of cells latently infected with Kaposi's sarcoma-associated herpes virus. J Immunol. 2000 Aug 15; 165(4):2077-83.J Immunol2000-08-15T00:00:002000Impaired CTL recognition of cells latently infected with Kaposi's sarcoma-associated herpes virus.17507468Crawford H, Prado JG, Leslie A, Hué S, Honeyborne I, Reddy S, van der Stok M, Mncube Z, Brander C, Rousseau C, Mullins JI, Kaslow R, Goepfert P, Allen S, Hunter E, Mulenga J, Kiepiela P, Walker BD, Goulder PJJournal of virologyCompensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restricted Gag epitope in chronic human immunodeficiency virus type 1 infection. J Virol. 2007 Aug; 81(15):8346-51.J Virol2007-05-16T00:00:002007Compensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restricted Gag epitope in chronic human immunodeficiency virus type 1 infection.11360218Cohen DE, Walker BDClinical infectious diseases : an official publication of the Infectious Diseases Society of AmericaHuman immunodeficiency virus pathogenesis and prospects for immune control in patients with established infection. Clin Infect Dis. 2001 Jun 15; 32(12):1756-68.Clin Infect Dis2001-05-16T00:00:002001Human immunodeficiency virus pathogenesis and prospects for immune control in patients with established infection.12646660Montefiori DC, Altfeld M, Lee PK, Bilska M, Zhou J, Johnston MN, Gao F, Walker BD, Rosenberg ESJournal of immunology (Baltimore, Md. : 1950)Viremia control despite escape from a rapid and potent autologous neutralizing antibody response after therapy cessation in an HIV-1-infected individual. J Immunol. 2003 Apr 01; 170(7):3906-14.J Immunol2003-04-01T00:00:002003Viremia control despite escape from a rapid and potent autologous neutralizing antibody response after therapy cessation in an HIV-1-infected individual.12806627Somsouk M, Lauer GM, Casson D, Terella A, Day CL, Walker BD, Chung RTGastroenterologySpontaneous resolution of chronic hepatitis C virus disease after withdrawal of immunosuppression. Gastroenterology. 2003 Jun; 124(7):1946-9.Gastroenterology2003-06-01T00:00:002003Spontaneous resolution of chronic hepatitis C virus disease after withdrawal of immunosuppression.19605475Thobakgale CF, Prendergast A, Crawford H, Mkhwanazi N, Ramduth D, Reddy S, Molina C, Mncube Z, Leslie A, Prado J, Chonco F, Mphatshwe W, Tudor-Williams G, Jeena P, Blanckenberg N, Dong K, Kiepiela P, Coovadia H, Ndung'u T, Walker BD, Goulder PJJournal of virologyImpact of HLA in mother and child on disease progression of pediatric human immunodeficiency virus type 1 infection. J Virol. 2009 Oct; 83(19):10234-44.J Virol2009-07-15T00:00:002009Impact of HLA in mother and child on disease progression of pediatric human immunodeficiency virus type 1 infection.19656066Pereyra F, Palmer S, Miura T, Block BL, Wiegand A, Rothchild AC, Baker B, Rosenberg R, Cutrell E, Seaman MS, Coffin JM, Walker BDThe Journal of infectious diseasesPersistent low-level viremia in HIV-1 elite controllers and relationship to immunologic parameters. J Infect Dis. 2009 Sep 15; 200(6):984-90.J Infect Dis2009-09-15T00:00:002009Persistent low-level viremia in HIV-1 elite controllers and relationship to immunologic parameters.14517700Delgado JC, Leung JY, Baena A, Clavijo OP, Vittinghoff E, Buchbinder S, Wolinsky S, Addo M, Walker BD, Yunis EJ, Goldfeld AEImmunogeneticsThe -1030/-862-linked TNF promoter single-nucleotide polymorphisms are associated with the inability to control HIV-1 viremia. Immunogenetics. 2003 Oct; 55(7):497-501.Immunogenetics2003-09-27T00:00:002003The -1030/-862-linked TNF promoter single-nucleotide polymorphisms are associated with the inability to control HIV-1 viremia.20445539Kosmrlj A, Read EL, Qi Y, Allen TM, Altfeld M, Deeks SG, Pereyra F, Carrington M, Walker BD, Chakraborty AKNatureEffects of thymic selection of the T-cell repertoire on HLA class I-associated control of HIV infection. Nature. 2010 May 20; 465(7296):350-4.Nature2010-05-05T00:00:002010Effects of thymic selection of the T-cell repertoire on HLA class I-associated control of HIV infection.Authorship 1057735729670239Clayton KL, Collins DR, Lengieza J, Ghebremichael M, Dotiwala F, Lieberman J, Walker BDNature immunologyResistance of HIV-infected macrophages to CD8+ T lymphocyte-mediated killing drives activation of the immune system. Nat Immunol. 2018 05; 19(5):475-486.Nat Immunol2018-04-18T00:00:002018Resistance of HIV-infected macrophages to CD8+ T lymphocyte-mediated killing drives activation of the immune system.15113900Brainard DM, Tharp WG, Granado E, Miller N, Trocha AK, Ren XH, Conrad B, Terwilliger EF, Wyatt R, Walker BD, Poznansky MCJournal of virologyMigration of antigen-specific T cells away from CXCR4-binding human immunodeficiency virus type 1 gp120. J Virol. 2004 May; 78(10):5184-93.J Virol2004-05-01T00:00:002004Migration of antigen-specific T cells away from CXCR4-binding human immunodeficiency virus type 1 gp120.16028131Woodberry T, Suscovich TJ, Henry LM, Martin JN, Dollard S, O'Connor PG, Davis JK, Osmond D, Lee TH, Kedes DH, Khatri A, Lee J, Walker BD, Scadden DT, Brander CThe Journal of infectious diseasesImpact of Kaposi sarcoma-associated herpesvirus (KSHV) burden and HIV coinfection on the detection of T cell responses to KSHV ORF73 and ORF65 proteins. J Infect Dis. 2005 Aug 15; 192(4):622-9.J Infect Dis2005-07-15T00:00:002005Impact of Kaposi sarcoma-associated herpesvirus (KSHV) burden and HIV coinfection on the detection of T cell responses to KSHV ORF73 and ORF65 proteins.16206065Woodberry T, Suscovich TJ, Henry LM, Davis JK, Frahm N, Walker BD, Scadden DT, Wang F, Brander CThe Journal of infectious diseasesDifferential targeting and shifts in the immunodominance of Epstein-Barr virus--specific CD8 and CD4 T cell responses during acute and persistent infection. J Infect Dis. 2005 Nov 01; 192(9):1513-24.J Infect Dis2005-09-26T00:00:002005Differential targeting and shifts in the immunodominance of Epstein-Barr virus--specific CD8 and CD4 T cell responses during acute and persistent infection.19091871Schneidewind A, Brumme ZL, Brumme CJ, Power KA, Reyor LL, O'Sullivan K, Gladden A, Hempel U, Kuntzen T, Wang YE, Oniangue-Ndza C, Jessen H, Markowitz M, Rosenberg ES, Sékaly RP, Kelleher AD, Walker BD, Allen TMJournal of virologyTransmission and long-term stability of compensated CD8 escape mutations. J Virol. 2009 Apr; 83(8):3993-7.J Virol2008-12-17T00:00:002008Transmission and long-term stability of compensated CD8 escape mutations.19690614Brumme ZL, John M, Carlson JM, Brumme CJ, Chan D, Brockman MA, Swenson LC, Tao I, Szeto S, Rosato P, Sela J, Kadie CM, Frahm N, Brander C, Haas DW, Riddler SA, Haubrich R, Walker BD, Harrigan PR, Heckerman D, Mallal SPloS oneHLA-associated immune escape pathways in HIV-1 subtype B Gag, Pol and Nef proteins. PLoS One. 2009 Aug 19; 4(8):e6687.PLoS One2009-08-19T00:00:002009HLA-associated immune escape pathways in HIV-1 subtype B Gag, Pol and Nef proteins.20942750Mureithi MW, Cohen K, Moodley R, Poole D, Mncube Z, Kasmar A, Moody DB, Goulder PJ, Walker BD, Altfeld M, Ndung'u TAIDS research and human retrovirusesImpairment of CD1d-restricted natural killer T cells in chronic HIV type 1 clade C infection. AIDS Res Hum Retroviruses. 2011 May; 27(5):501-9.AIDS Res Hum Retroviruses2010-12-13T00:00:002010Impairment of CD1d-restricted natural killer T cells in chronic HIV type 1 clade C infection.2825177Walker BD, Kowalski M, Goh WC, Kozarsky K, Krieger M, Rosen C, Rohrschneider L, Haseltine WA, Sodroski JProceedings of the National Academy of Sciences of the United States of AmericaInhibition of human immunodeficiency virus syncytium formation and virus replication by castanospermine. Proc Natl Acad Sci U S A. 1987 Nov; 84(22):8120-4.Proc Natl Acad Sci U S A1987-11-01T00:00:001987Inhibition of human immunodeficiency virus syncytium formation and virus replication by castanospermine.2829022Fisher RA, Bertonis JM, Meier W, Johnson VA, Costopoulos DS, Liu T, Tizard R, Walker BD, Hirsch MS, Schooley RTNatureHIV infection is blocked in vitro by recombinant soluble CD4. Nature. 1988 Jan 07; 331(6151):76-8.Nature1988-01-07T00:00:001988HIV infection is blocked in vitro by recombinant soluble CD4.2829023Hussey RE, Richardson NE, Kowalski M, Brown NR, Chang HC, Siliciano RF, Dorfman T, Walker B, Sodroski J, Reinherz ELNatureA soluble CD4 protein selectively inhibits HIV replication and syncytium formation. Nature. 1988 Jan 07; 331(6151):78-81.Nature1988-01-07T00:00:001988A soluble CD4 protein selectively inhibits HIV replication and syncytium formation.23015721Chopera DR, Cotton LA, Zawaira A, Mann JK, Ngandu NK, Ntale R, Carlson JM, Mlisana K, Woodman Z, de Assis Rosa D, Martin E, Miura T, Pereyra F, Walker BD, Gray CM, Martin DP, Ndung'u T, Brockman MA, Karim SA, Brumme ZL, Williamson CJournal of virologyIntersubtype differences in the effect of a rare p24 gag mutation on HIV-1 replicative fitness. J Virol. 2012 Dec; 86(24):13423-33.J Virol2012-09-26T00:00:002012Intersubtype differences in the effect of a rare p24 gag mutation on HIV-1 replicative fitness.Authorship 10328510Authorship 1011162Kaufmann DE, Kavanagh DG, Pereyra F, Zaunders JJ, Mackey EW, Miura T, Palmer S, Brockman M, Rathod A, Piechocka-Trocha A, Baker B, Zhu B, Le Gall S, Waring MT, Ahern R, Moss K, Kelleher AD, Coffin JM, Freeman GJ, Rosenberg ES, Walker BDNat Immunol. 2007 Nov;8(11):1246-54. Epub 2007 Sep 30.Upregulation of CTLA-4 by HIV-specific CD4(+) T cells correlates with disease progression and defines a reversible immune dysfunction. Nat Immunol. 2007 Nov;8(11):1246-54. Epub 2007 Sep 30. 2007; 8(11):1246-54.2007-09-30T00:00:002007Upregulation of CTLA-4 by HIV-specific CD4(+) T cells correlates with disease progression and defines a reversible immune dysfunction7593618Koziel MJ, Dudley D, Afdhal N, Grakoui A, Rice CM, Choo QL, Houghton M, Walker BDThe Journal of clinical investigationHLA class I-restricted cytotoxic T lymphocytes specific for hepatitis C virus. Identification of multiple epitopes and characterization of patterns of cytokine release. J Clin Invest. 1995 Nov; 96(5):2311-21.J Clin Invest1995-11-01T00:00:001995HLA class I-restricted cytotoxic T lymphocytes specific for hepatitis C virus. Identification of multiple epitopes and characterization of patterns of cytokine release.7679694Zweerink HJ, Gammon MC, Utz U, Sauma SY, Harrer T, Hawkins JC, Johnson RP, Sirotina A, Hermes JD, Walker BDJournal of immunology (Baltimore, Md. : 1950)Presentation of endogenous peptides to MHC class I-restricted cytotoxic T lymphocytes in transport deletion mutant T2 cells. J Immunol. 1993 Mar 01; 150(5):1763-71.J Immunol1993-03-01T00:00:001993Presentation of endogenous peptides to MHC class I-restricted cytotoxic T lymphocytes in transport deletion mutant T2 cells.Authorship 1065942929760420Siciliano V, DiAndreth B, Monel B, Beal J, Huh J, Clayton KL, Wroblewska L, McKeon A, Walker BD, Weiss RNature communicationsEngineering modular intracellular protein sensor-actuator devices. Nat Commun. 2018 05 14; 9(1):1881.Nat Commun2018-05-14T00:00:002018Engineering modular intracellular protein sensor-actuator devices.17475911Schulze Zur Wiesch J, Lauer GM, Timm J, Kuntzen T, Neukamm M, Berical A, Jones AM, Nolan BE, Longworth SA, Kasprowicz V, McMahon C, Wurcel A, Lohse AW, Lewis-Ximenez LL, Chung RT, Kim AY, Allen TM, Walker BDBloodImmunologic evidence for lack of heterologous protection following resolution of HCV in patients with non-genotype 1 infection. Blood. 2007 Sep 01; 110(5):1559-69.Blood2007-05-02T00:00:002007Immunologic evidence for lack of heterologous protection following resolution of HCV in patients with non-genotype 1 infection.17952079Dolan MJ, Kulkarni H, Camargo JF, He W, Smith A, Anaya JM, Miura T, Hecht FM, Mamtani M, Pereyra F, Marconi V, Mangano A, Sen L, Bologna R, Clark RA, Anderson SA, Delmar J, O'Connell RJ, Lloyd A, Martin J, Ahuja SS, Agan BK, Walker BD, Deeks SG, Ahuja SKNature immunologyCCL3L1 and CCR5 influence cell-mediated immunity and affect HIV-AIDS pathogenesis via viral entry-independent mechanisms. Nat Immunol. 2007 Dec; 8(12):1324-36.Nat Immunol2007-10-21T00:00:002007CCL3L1 and CCR5 influence cell-mediated immunity and affect HIV-AIDS pathogenesis via viral entry-independent mechanisms.18160439Kasprowicz V, Schulze Zur Wiesch J, Kuntzen T, Nolan BE, Longworth S, Berical A, Blum J, McMahon C, Reyor LL, Elias N, Kwok WW, McGovern BG, Freeman G, Chung RT, Klenerman P, Lewis-Ximenez L, Walker BD, Allen TM, Kim AY, Lauer GMJournal of virologyHigh level of PD-1 expression on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells during acute HCV infection, irrespective of clinical outcome. J Virol. 2008 Mar; 82(6):3154-60.J Virol2007-12-26T00:00:002007High level of PD-1 expression on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells during acute HCV infection, irrespective of clinical outcome.18728248Lichterfeld M, Mou D, Cung TD, Williams KL, Waring MT, Huang J, Pereyra F, Trocha A, Freeman GJ, Rosenberg ES, Walker BD, Yu XGBloodTelomerase activity of HIV-1-specific CD8+ T cells: constitutive up-regulation in controllers and selective increase by blockade of PD ligand 1 in progressors. Blood. 2008 Nov 01; 112(9):3679-87.Blood2008-08-26T00:00:002008Telomerase activity of HIV-1-specific CD8+ T cells: constitutive up-regulation in controllers and selective increase by blockade of PD ligand 1 in progressors.19194317Apuzzo LG, Vaida F, Gallant JE, Ernstrom KB, Little SJ, Routy JP, Collier AC, Conway B, Markowitz MH, Hecht FM, Walker BD, Connick E, Margolick JBJournal of acquired immune deficiency syndromes (1999)Tolerability and efficacy of PI versus NNRTI-based regimens in subjects receiving HAART during acute or early HIV infection. J Acquir Immune Defic Syndr. 2009 Mar 01; 50(3):267-75.J Acquir Immune Defic Syndr2009-03-01T00:00:002009Tolerability and efficacy of PI versus NNRTI-based regimens in subjects receiving HAART during acute or early HIV infection.19287373Scheid JF, Mouquet H, Feldhahn N, Seaman MS, Velinzon K, Pietzsch J, Ott RG, Anthony RM, Zebroski H, Hurley A, Phogat A, Chakrabarti B, Li Y, Connors M, Pereyra F, Walker BD, Wardemann H, Ho D, Wyatt RT, Mascola JR, Ravetch JV, Nussenzweig MCNatureBroad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals. Nature. 2009 Apr 02; 458(7238):636-40.Nature2009-03-15T00:00:002009Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals.Authorship 1067297529793949Baiyegunhi O, Ndlovu B, Ogunshola F, Ismail N, Walker BD, Ndung'u T, Ndhlovu ZMJournal of virologyFrequencies of Circulating Th1-Biased T Follicular Helper Cells in Acute HIV-1 Infection Correlate with the Development of HIV-Specific Antibody Responses and Lower Set Point Viral Load. J Virol. 2018 08 01; 92(15).J Virol2018-07-17T00:00:002018Frequencies of Circulating Th1-Biased T Follicular Helper Cells in Acute HIV-1 Infection Correlate with the Development of HIV-Specific Antibody Responses and Lower Set Point Viral Load.20588158Williams K, Seiss K, Beamon J, Pereyra F, Rosenberg ES, Walker BD, Yu XG, Lichterfeld MAIDS (London, England)Epigenetic regulation of telomerase expression in HIV-1-specific CD8+ T cells. 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J Immunol. 2011 Jun 15; 186(12):6914-24.J Immunol2011-05-16T00:00:002011Mosaic HIV-1 Gag antigens can be processed and presented to human HIV-specific CD8+ T cells.Authorship 1031494716511771Kassutto S, Maghsoudi K, Johnston MN, Robbins GK, Burgett NC, Sax PE, Cohen D, Pae E, Davis B, Zachary K, Basgoz N, D'agata EM, DeGruttola V, Walker BD, Rosenberg ESClinical infectious diseases : an official publication of the Infectious Diseases Society of AmericaLongitudinal analysis of clinical markers following antiretroviral therapy initiated during acute or early HIV type 1 infection. 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J Virol Aug;. 2007; 81(16):8439-50.2007-06-06T00:00:002007Decreased CXCR3+ CD8 T-cells in advanced HIV infection suggests a homing defect contributes to CTL dysfunction20631139Huang J, Burke PS, Cung TD, Pereyra F, Toth I, Walker BD, Borges L, Lichterfeld M, Yu XGJournal of virologyLeukocyte immunoglobulin-like receptors maintain unique antigen-presenting properties of circulating myeloid dendritic cells in HIV-1-infected elite controllers. J Virol. 2010 Sep; 84(18):9463-71.J Virol2010-07-14T00:00:002010Leukocyte immunoglobulin-like receptors maintain unique antigen-presenting properties of circulating myeloid dendritic cells in HIV-1-infected elite controllers.20739527Honeyborne I, Codoñer FM, Leslie A, Tudor-Williams G, Luzzi G, Ndung'u T, Walker BD, Goulder PJ, Prado JGJournal of virologyHLA-Cw*03-restricted CD8+ T-cell responses targeting the HIV-1 gag major homology region drive virus immune escape and fitness constraints compensated for by intracodon variation. 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PLoS Med. 2006 Oct; 3(10):e403.PLoS Med2006-10-01T00:00:002006HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8(+) T Cell Response against HIV-1.18579582Alter G, Rihn S, Streeck H, Teigen N, Piechocka-Trocha A, Moss K, Cohen K, Meier A, Pereyra F, Walker B, Altfeld MJournal of virologyLigand-independent exhaustion of killer immunoglobulin-like receptor-positive CD8+ T cells in human immunodeficiency virus type 1 infection. J Virol. 2008 Oct; 82(19):9668-77.J Virol2008-06-25T00:00:002008Ligand-independent exhaustion of killer immunoglobulin-like receptor-positive CD8+ T cells in human immunodeficiency virus type 1 infection.22496218Thobakgale CF, Fadda L, Lane K, Toth I, Pereyra F, Bazner S, Ndung'u T, Walker BD, Rosenberg ES, Alter G, Carrington M, Allen TM, Altfeld MJournal of virologyFrequent and strong antibody-mediated natural killer cell activation in response to HIV-1 Env in individuals with chronic HIV-1 infection. J Virol. 2012 Jun; 86(12):6986-93.J Virol2012-04-11T00:00:002012Frequent and strong antibody-mediated natural killer cell activation in response to HIV-1 Env in individuals with chronic HIV-1 infection.Authorship 10874123130085241Namazi G, Fajnzylber JM, Aga E, Bosch RJ, Acosta EP, Sharaf R, Hartogensis W, Jacobson JM, Connick E, Volberding P, Skiest D, Margolis D, Sneller MC, Little SJ, Gianella S, Smith DM, Kuritzkes DR, Gulick RM, Mellors JW, Mehraj V, Gandhi RT, Mitsuyasu R, Schooley RT, Henry K, Tebas P, Deeks SG, Chun TW, Collier AC, Routy JP, Hecht FM, Walker BD, Li JZThe Journal of infectious diseasesThe Control of HIV After Antiretroviral Medication Pause (CHAMP) Study: Posttreatment Controllers Identified From 14 Clinical Studies. 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J Immunol Methods. 2009 Apr 15; 343(2):65-7.J Immunol Methods2008-12-25T00:00:002008A method for identification of HIV gp140 binding memory B cells in human blood.19365081Brockman MA, Kwon DS, Tighe DP, Pavlik DF, Rosato PC, Sela J, Porichis F, Le Gall S, Waring MT, Moss K, Jessen H, Pereyra F, Kavanagh DG, Walker BD, Kaufmann DEBloodIL-10 is up-regulated in multiple cell types during viremic HIV infection and reversibly inhibits virus-specific T cells. Blood. 2009 Jul 09; 114(2):346-56.Blood2009-04-13T00:00:002009IL-10 is up-regulated in multiple cell types during viremic HIV infection and reversibly inhibits virus-specific T cells.Authorship 10878611630120121Lofano G, Gorman MJ, Yousif AS, Yu WH, Fox JM, Dugast AS, Ackerman ME, Suscovich TJ, Weiner J, Barouch D, Streeck H, Little S, Smith D, Richman D, Lauffenburger D, Walker BD, Diamond MS, Alter GScience immunologyAntigen-specific antibody Fc glycosylation enhances humoral immunity via the recruitment of complement. 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AIDS. 2009 Jan 14; 23(2):259-62.AIDS2009-01-14T00:00:002009Epidemiologically linked transmission of HIV-1 illustrates the impact of host genetics on virological outcome.19458000Streeck H, Jolin JS, Qi Y, Yassine-Diab B, Johnson RC, Kwon DS, Addo MM, Brumme C, Routy JP, Little S, Jessen HK, Kelleher AD, Hecht FM, Sekaly RP, Rosenberg ES, Walker BD, Carrington M, Altfeld MJournal of virologyHuman immunodeficiency virus type 1-specific CD8+ T-cell responses during primary infection are major determinants of the viral set point and loss of CD4+ T cells. J Virol. 2009 Aug; 83(15):7641-8.J Virol2009-05-20T00:00:002009Human immunodeficiency virus type 1-specific CD8+ T-cell responses during primary infection are major determinants of the viral set point and loss of CD4+ T cells.Authorship 1059791120132004Spentzou A, Bergin P, Gill D, Cheeseman H, Ashraf A, Kaltsidis H, Cashin-Cox M, Anjarwalla I, Steel A, Higgs C, Pozniak A, Piechocka-Trocha A, Wong J, Anzala O, Karita E, Dally L, Gotch F, Walker B, Gilmour J, Hayes PThe Journal of infectious diseasesViral inhibition assay: a CD8 T cell neutralization assay for use in clinical trials of HIV-1 vaccine candidates. J Infect Dis. 2010 Mar; 201(5):720-9.J Infect Dis2010-03-01T00:00:002010Viral inhibition assay: a CD8 T cell neutralization assay for use in clinical trials of HIV-1 vaccine candidates.20882016Mouquet H, Scheid JF, Zoller MJ, Krogsgaard M, Ott RG, Shukair S, Artyomov MN, Pietzsch J, Connors M, Pereyra F, Walker BD, Ho DD, Wilson PC, Seaman MS, Eisen HN, Chakraborty AK, Hope TJ, Ravetch JV, Wardemann H, Nussenzweig MCNaturePolyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation. Nature. 2010 Sep 30; 467(7315):591-5.Nature2010-09-30T00:00:002010Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation.21097698Rodríguez-García M, Porichis F, de Jong OG, Levi K, Diefenbach TJ, Lifson JD, Freeman GJ, Walker BD, Kaufmann DE, Kavanagh DGJournal of leukocyte biologyExpression of PD-L1 and PD-L2 on human macrophages is up-regulated by HIV-1 and differentially modulated by IL-10. J Leukoc Biol. 2011 Apr; 89(4):507-15.J Leukoc Biol2010-11-19T00:00:002010Expression of PD-L1 and PD-L2 on human macrophages is up-regulated by HIV-1 and differentially modulated by IL-10.21257739Julg B, Moodley ES, Qi Y, Ramduth D, Reddy S, Mncube Z, Gao X, Goulder PJ, Detels R, Ndung'u T, Walker BD, Carrington MThe Journal of infectious diseasesPossession of HLA class II DRB1*1303 associates with reduced viral loads in chronic HIV-1 clade C and B infection. J Infect Dis. 2011 Mar 15; 203(6):803-9.J Infect Dis2011-01-21T00:00:002011Possession of HLA class II DRB1*1303 associates with reduced viral loads in chronic HIV-1 clade C and B infection.Authorship 1185982Frahm N, Kaufmann DE, Yusim K, Muldoon M, Kesmir C, Linde CH, Fischer W, Allen TM, Li B, McMahon BH, Faircloth KL, Hewitt HS, Mackey EW, Miura T, Khatri A, Wolinsky S, McMichael A, Funkhouser RK, Walker BD, Brander C, Korber BTJ Immunol. 2007 Nov 15;Increased Sequence Diversity Coverage Improves Detection of HIV-Specific T Cell Responses. J Immunol. 2007 Nov 15;. 2007; 179(10):6638-50.2007-11-15T00:00:002007Increased Sequence Diversity Coverage Improves Detection of HIV-Specific T Cell Responses7865293Mestecky J, Walker MC, Mathieson BJ, Walker BDAIDS research and human retrovirusesConference on advances in AIDS vaccine development--1993. Summary: Mucosal Immunity Workshop. AIDS Res Hum Retroviruses. 1994; 10 Suppl 2:S165-70.AIDS Res Hum Retroviruses1994-01-01T00:00:001994Conference on advances in AIDS vaccine development--1993. Summary: Mucosal Immunity Workshop.Authorship 119223920660184Leslie A, Matthews PC, Listgarten J, Carlson JM, Kadie C, Ndung'u T, Brander C, Coovadia H, Walker BD, Heckerman D, Goulder PJJournal of virologyAdditive contribution of HLA class I alleles in the immune control of HIV-1 infection. J Virol. 2010 Oct; 84(19):9879-88.J Virol2010-07-21T00:00:002010Additive contribution of HLA class I alleles in the immune control of HIV-1 infection.22379086Carlson JM, Listgarten J, Pfeifer N, Tan V, Kadie C, Walker BD, Ndung'u T, Shapiro R, Frater J, Brumme ZL, Goulder PJ, Heckerman DJournal of virologyWidespread impact of HLA restriction on immune control and escape pathways of HIV-1. J Virol. 2012 May; 86(9):5230-43.J Virol2012-02-29T00:00:002012Widespread impact of HLA restriction on immune control and escape pathways of HIV-1.22685549Mitchell JE, Chetty S, Govender P, Pillay M, Jaggernath M, Kasmar A, Ndung'u T, Klenerman P, Walker BD, Kasprowicz VOPloS oneProspective monitoring reveals dynamic levels of T cell immunity to Mycobacterium tuberculosis in HIV infected individuals. PLoS One. 2012; 7(6):e37920.PLoS One2012-06-07T00:00:002012Prospective monitoring reveals dynamic levels of T cell immunity to Mycobacterium tuberculosis in HIV infected individuals.22779271Walker BDScientific AmericanSecrets of the HIV controllers: A rare group of HIV-positive individuals need no medicine to keep the virus in check. Their good fortune could point the way to more powerful treatments--and perhaps a vaccine. Sci Am. 2012 Jul; 307(1):44-51.Sci Am2012-07-01T00:00:002012Secrets of the HIV controllers: A rare group of HIV-positive individuals need no medicine to keep the virus in check. Their good fortune could point the way to more powerful treatments--and perhaps a vaccine.2451288Walker BD, Flexner C, Paradis TJ, Fuller TC, Hirsch MS, Schooley RT, Moss BScience (New York, N.Y.)HIV-1 reverse transcriptase is a target for cytotoxic T lymphocytes in infected individuals. Science. 1988 Apr 01; 240(4848):64-6.Science1988-04-01T00:00:001988HIV-1 reverse transcriptase is a target for cytotoxic T lymphocytes in infected individuals.19828603Prado JG, Prendergast A, Thobakgale C, Molina C, Tudor-Williams G, Ndung'u T, Walker BD, Goulder PJournal of virologyReplicative capacity of human immunodeficiency virus type 1 transmitted from mother to child is associated with pediatric disease progression rate. J Virol. 2010 Jan; 84(1):492-502.J Virol2010-01-01T00:00:002010Replicative capacity of human immunodeficiency virus type 1 transmitted from mother to child is associated with pediatric disease progression rate.Authorship 12184911Authorship 1094377430217812Ndung'u T, Dong KL, Kwon DS, Walker BDScience immunologyA FRESH approach: Combining basic science and social good. Sci Immunol. 2018 09 14; 3(27).Sci Immunol2018-09-14T00:00:002018A FRESH approach: Combining basic science and social good.21402549Li JZ, Brumme ZL, Brumme CJ, Wang H, Spritzler J, Robertson MN, Lederman MM, Carrington M, Walker BD, Schooley RT, Kuritzkes DRThe Journal of infectious diseasesFactors associated with viral rebound in HIV-1-infected individuals enrolled in a therapeutic HIV-1 gag vaccine trial. J Infect Dis. 2011 Apr 01; 203(7):976-83.J Infect Dis2011-04-01T00:00:002011Factors associated with viral rebound in HIV-1-infected individuals enrolled in a therapeutic HIV-1 gag vaccine trial.23289738Mwimanzi P, Markle TJ, Martin E, Ogata Y, Kuang XT, Tokunaga M, Mahiti M, Pereyra F, Miura T, Walker BD, Brumme ZL, Brockman MA, Ueno TRetrovirologyAttenuation of multiple Nef functions in HIV-1 elite controllers. Retrovirology. 2013 Jan 07; 10:1.Retrovirology2013-01-07T00:00:002013Attenuation of multiple Nef functions in HIV-1 elite controllers.23323905Walker BD, Hirsch MSThe New England journal of medicineAntiretroviral therapy in early HIV infection. N Engl J Med. 2013 Jan 17; 368(3):279-81.N Engl J Med2013-01-17T00:00:002013Antiretroviral therapy in early HIV infection.Pantaleo G, Walker BD, editors.Retroviral Immunology: Immune Response and Restoration. 2001.2001-01-01T00:00:002001Retroviral Immunology: Immune Response and RestorationFrater A.J., Brown H., Oxenius A., Gunthard HF., Hirschel B., Robinson N., Leslie A.J., Payne R., Crawford H., Prendergast A., Brander C., Kiepiela P., Walker B.D., Goulder P.J., McLean A., Phillips RE. J VirolEffective T cell responses select HIV-1 mutants and slow disease progression. 81(12):6742-51. Epub 2007 Apr 4. J Virol. 2007; 81(12):6742-51.2007-04-04T00:00:002007Effective T cell responses select HIV-1 mutants and slow disease progression. 81(12):6742-51. Epub 2007 Apr 4Authorship 1043752Lisziewicz J, Rosenberg E, Lieberman J, Jessen H, Lopalso L, Siliciano R, Walker B, Lori F.NEJMControl of HIV despite the discontinuation of antiretroviral therapy. NEJM. 1999; 340:1683-4.1999-01-01T00:00:001999Control of HIV despite the discontinuation of antiretroviral therapy7523570Tsomides TJ, Aldovini A, Johnson RP, Walker BD, Young RA, Eisen HNThe Journal of experimental medicineNaturally processed viral peptides recognized by cytotoxic T lymphocytes on cells chronically infected by human immunodeficiency virus type 1. J Exp Med. 1994 Oct 01; 180(4):1283-93.J Exp Med1994-10-01T00:00:001994Naturally processed viral peptides recognized by cytotoxic T lymphocytes on cells chronically infected by human immunodeficiency virus type 1.7637019Iversen AK, Shpaer EG, Rodrigo AG, Hirsch MS, Walker BD, Sheppard HW, Merigan TC, Mullins JIJournal of virologyPersistence of attenuated rev genes in a human immunodeficiency virus type 1-infected asymptomatic individual. J Virol. 1995 Sep; 69(9):5743-53.J Virol1995-09-01T00:00:001995Persistence of attenuated rev genes in a human immunodeficiency virus type 1-infected asymptomatic individual.Authorship 1097472430289807Chowdhury FZ, Ouyang Z, Buzon M, Walker BD, Lichterfeld M, Yu XGAIDS (London, England)Metabolic pathway activation distinguishes transcriptional signatures of CD8+ T cells from HIV-1 elite controllers. AIDS. 2018 11 28; 32(18):2669-2677.AIDS2018-11-28T00:00:002018Metabolic pathway activation distinguishes transcriptional signatures of CD8+ T cells from HIV-1 elite controllers.7865295Walker MC, Walker BD, Mestecky J, Mathieson BJAIDS research and human retrovirusesConference on advances in AIDS vaccine development--1993. Summary: cytotoxic T-cell Immunity Workshop. AIDS Res Hum Retroviruses. 1994; 10 Suppl 2:S177-9.AIDS Res Hum Retroviruses1994-01-01T00:00:001994Conference on advances in AIDS vaccine development--1993. Summary: cytotoxic T-cell Immunity Workshop.15075505Smith DE, Walker BD, Cooper DA, Rosenberg ES, Kaldor JMAIDS (London, England)Is antiretroviral treatment of primary HIV infection clinically justified on the basis of current evidence? AIDS. 2004 Mar 26; 18(5):709-18.AIDS2004-03-26T00:00:002004Is antiretroviral treatment of primary HIV infection clinically justified on the basis of current evidence?15592417Kiepiela P, Leslie AJ, Honeyborne I, Ramduth D, Thobakgale C, Chetty S, Rathnavalu P, Moore C, Pfafferott KJ, Hilton L, Zimbwa P, Moore S, Allen T, Brander C, Addo MM, Altfeld M, James I, Mallal S, Bunce M, Barber LD, Szinger J, Day C, Klenerman P, Mullins J, Korber B, Coovadia HM, Walker BD, Goulder PJNatureDominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA. Nature. 2004 Dec 09; 432(7018):769-75.Nature2004-12-09T00:00:002004Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA.16206073Ramduth D, Chetty P, Mngquandaniso NC, Nene N, Harlow JD, Honeyborne I, Ntumba N, Gappoo S, Henry C, Jeena P, Addo MM, Altfeld M, Brander C, Day C, Coovadia H, Kiepiela P, Goulder P, Walker BThe Journal of infectious diseasesDifferential immunogenicity of HIV-1 clade C proteins in eliciting CD8+ and CD4+ cell responses. J Infect Dis. 2005 Nov 01; 192(9):1588-96.J Infect Dis2005-09-30T00:00:002005Differential immunogenicity of HIV-1 clade C proteins in eliciting CD8+ and CD4+ cell responses.17389912Addo MM, Draenert R, Rathod A, Verrill CL, Davis BT, Gandhi RT, Robbins GK, Basgoz NO, Stone DR, Cohen DE, Johnston MN, Flynn T, Wurcel AG, Rosenberg ES, Altfeld M, Walker BDPloS oneFully differentiated HIV-1 specific CD8+ T effector cells are more frequently detectable in controlled than in progressive HIV-1 infection. PLoS One. 2007 Mar 28; 2(3):e321.PLoS One2007-03-28T00:00:002007Fully differentiated HIV-1 specific CD8+ T effector cells are more frequently detectable in controlled than in progressive HIV-1 infection.17439522Timm J, Neukamm M, Kuntzen T, Kim AY, Chung RT, Brander C, Lauer GM, Walker BD, Allen TMJournal of viral hepatitisCharacterization of full-length hepatitis C virus genotype 4 sequences. J Viral Hepat. 2007 May; 14(5):330-7.J Viral Hepat2007-05-01T00:00:002007Characterization of full-length hepatitis C virus genotype 4 sequences.17804503Yu XG, Lichterfeld M, Williams KL, Martinez-Picado J, Walker BDJournal of virologyRandom T-cell receptor recruitment in human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T cells from genetically identical twins infected with the same HIV-1 strain. J Virol. 2007 Nov; 81(22):12666-9.J Virol2007-09-05T00:00:002007Random T-cell receptor recruitment in human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T cells from genetically identical twins infected with the same HIV-1 strain.9060675Yang OO, Kalams SA, Trocha A, Cao H, Luster A, Johnson RP, Walker BDJournal of virologySuppression of human immunodeficiency virus type 1 replication by CD8+ cells: evidence for HLA class I-restricted triggering of cytolytic and noncytolytic mechanisms. J Virol. 1997 Apr; 71(4):3120-8.J Virol1997-04-01T00:00:001997Suppression of human immunodeficiency virus type 1 replication by CD8+ cells: evidence for HLA class I-restricted triggering of cytolytic and noncytolytic mechanisms.1385523Koziel MJ, Dudley D, Wong JT, Dienstag J, Houghton M, Ralston R, Walker BDJournal of immunology (Baltimore, Md. : 1950)Intrahepatic cytotoxic T lymphocytes specific for hepatitis C virus in persons with chronic hepatitis. J Immunol. 1992 Nov 15; 149(10):3339-44.J Immunol1992-11-15T00:00:001992Intrahepatic cytotoxic T lymphocytes specific for hepatitis C virus in persons with chronic hepatitis.7587372Kalams SA, Walker BDCurrent topics in microbiology and immunologyCytotoxic T lymphocytes and HIV-1 related neurologic disorders. Curr Top Microbiol Immunol. 1995; 202:79-88.Curr Top Microbiol Immunol1995-01-01T00:00:001995Cytotoxic T lymphocytes and HIV-1 related neurologic disorders.19372861Kaufmann DE, Walker BDCurrent opinion in HIV and AIDSTreatment interruption to boost specific HIV immunity in acute infection. Curr Opin HIV AIDS. 2007 Jan; 2(1):21-5.Curr Opin HIV AIDS2007-01-01T00:00:002007Treatment interruption to boost specific HIV immunity in acute infection.20504921Miura T, Brumme ZL, Brockman MA, Rosato P, Sela J, Brumme CJ, Pereyra F, Kaufmann DE, Trocha A, Block BL, Daar ES, Connick E, Jessen H, Kelleher AD, Rosenberg E, Markowitz M, Schafer K, Vaida F, Iwamoto A, Little S, Walker BDJournal of virologyImpaired replication capacity of acute/early viruses in persons who become HIV controllers. J Virol. 2010 Aug; 84(15):7581-91.J Virol2010-05-26T00:00:002010Impaired replication capacity of acute/early viruses in persons who become HIV controllers.20550452Julg B, Pereyra F, Buzón MJ, Piechocka-Trocha A, Clark MJ, Baker BM, Lian J, Miura T, Martinez-Picado J, Addo MM, Walker BDClinical infectious diseases : an official publication of the Infectious Diseases Society of AmericaInfrequent recovery of HIV from but robust exogenous infection of activated CD4(+) T cells in HIV elite controllers. Clin Infect Dis. 2010 Jul 15; 51(2):233-8.Clin Infect Dis2010-07-15T00:00:002010Infrequent recovery of HIV from but robust exogenous infection of activated CD4(+) T cells in HIV elite controllers.22718199McLaren PJ, Ripke S, Pelak K, Weintrob AC, Patsopoulos NA, Jia X, Erlich RL, Lennon NJ, Kadie CM, Heckerman D, Gupta N, Haas DW, Deeks SG, Pereyra F, Walker BD, de Bakker PIHuman molecular geneticsFine-mapping classical HLA variation associated with durable host control of HIV-1 infection in African Americans. Hum Mol Genet. 2012 Oct 01; 21(19):4334-47.Hum Mol Genet2012-06-19T00:00:002012Fine-mapping classical HLA variation associated with durable host control of HIV-1 infection in African Americans.7523033Johnson RP, Walker BDCurrent topics in microbiology and immunologyCytotoxic T lymphocytes in human immunodeficiency virus infection: responses to structural proteins. Curr Top Microbiol Immunol. 1994; 189:35-63.Curr Top Microbiol Immunol1994-01-01T00:00:001994Cytotoxic T lymphocytes in human immunodeficiency virus infection: responses to structural proteins.8666925Kalams SA, Johnson RP, Dynan MJ, Hartman KE, Harrer T, Harrer E, Trocha AK, Blattner WA, Buchbinder SP, Walker BDThe Journal of experimental medicineT cell receptor usage and fine specificity of human immunodeficiency virus 1-specific cytotoxic T lymphocyte clones: analysis of quasispecies recognition reveals a dominant response directed against a minor in vivo variant. J Exp Med. 1996 Apr 01; 183(4):1669-79.J Exp Med1996-04-01T00:00:001996T cell receptor usage and fine specificity of human immunodeficiency virus 1-specific cytotoxic T lymphocyte clones: analysis of quasispecies recognition reveals a dominant response directed against a minor in vivo variant.8709196Yang OO, Kalams SA, Rosenzweig M, Trocha A, Jones N, Koziel M, Walker BD, Johnson RPJournal of virologyEfficient lysis of human immunodeficiency virus type 1-infected cells by cytotoxic T lymphocytes. J Virol. 1996 Sep; 70(9):5799-806.J Virol1996-09-01T00:00:001996Efficient lysis of human immunodeficiency virus type 1-infected cells by cytotoxic T lymphocytes.Microbiology11023459Schooley RT, Spino C, Kuritzkes D, Walker BD, Valentine FA, Hirsch MS, Cooney E, Friedland G, Kundu S, Merigan TC, McElrath MJ, Collier A, Plaeger S, Mitsuyasu R, Kahn J, Haslett P, Uherova P, deGruttola V, Chiu S, Zhang B, Jones G, Bell D, Ketter N, Twadell T, Chernoff D, Rosandich MThe Journal of infectious diseasesTwo double-blinded, randomized, comparative trials of 4 human immunodeficiency virus type 1 (HIV-1) envelope vaccines in HIV-1-infected individuals across a spectrum of disease severity: AIDS Clinical Trials Groups 209 and 214. J Infect Dis. 2000 Nov; 182(5):1357-64.J Infect Dis2000-10-09T00:00:002000Two double-blinded, randomized, comparative trials of 4 human immunodeficiency virus type 1 (HIV-1) envelope vaccines in HIV-1-infected individuals across a spectrum of disease severity: AIDS Clinical Trials Groups 209 and 214.Authorship 136271611172028Addo MM, Altfeld M, Rosenberg ES, Eldridge RL, Philips MN, Habeeb K, Khatri A, Brander C, Robbins GK, Mazzara GP, Goulder PJ, Walker BDProceedings of the National Academy of Sciences of the United States of AmericaThe HIV-1 regulatory proteins Tat and Rev are frequently targeted by cytotoxic T lymphocytes derived from HIV-1-infected individuals. Proc Natl Acad Sci U S A. 2001 Feb 13; 98(4):1781-6.Proc Natl Acad Sci U S A2001-02-13T00:00:002001The HIV-1 regulatory proteins Tat and Rev are frequently targeted by cytotoxic T lymphocytes derived from HIV-1-infected individuals.Lori F, Rosenberg E, Lieberman J, Foli A, Maserati R, Seminari E, Alberici F, Walker B, Lisziewicz J.AIDS Res Hum RetroHydroxyurea and Didanosine long-term treatment prevents HIV breakthrough and normalizes immune parameters. AIDS Res Hum Retro. 1999; 15:1333-1338.1999-01-01T00:00:001999Hydroxyurea and Didanosine long-term treatment prevents HIV breakthrough and normalizes immune parametersStreeck H, Lichterfeld M, Alter G, Meier A, Teigen N, Yassine-Diab B, Sidhu HK, Little S, Kelleher A, Routy JP, Rosenberg ES, Sekaly RP, Walker BD, Altfeld MJ Virol. 2007 Jul;Recognition of a defined region within p24 Gag by CD8+ T cells during primary HIV-1 infection in individuals expressing protective HLA class I alleles. J Virol. 2007 Jul;. 2007; 81(14):7725-31.2007-05-09T00:00:002007Recognition of a defined region within p24 Gag by CD8+ T cells during primary HIV-1 infection in individuals expressing protective HLA class I alleles11834942Yu XG, Shang H, Addo MM, Eldridge RL, Phillips MN, Feeney ME, Strick D, Brander C, Goulder PJ, Rosenberg ES, Walker BD, Altfeld MAIDS (London, England)Important contribution of p15 Gag-specific responses to the total Gag-specific CTL responses. AIDS. 2002 Feb 15; 16(3):321-8.AIDS2002-02-15T00:00:002002Important contribution of p15 Gag-specific responses to the total Gag-specific CTL responses.1693514Walker BD, Plata FAIDS (London, England)Cytotoxic T lymphocytes against HIV. AIDS. 1990 Mar; 4(3):177-84.AIDS1990-03-01T00:00:001990Cytotoxic T lymphocytes against HIV.12805449Feeney ME, Roosevelt KA, Tang Y, Pfafferott KJ, McIntosh K, Burchett SK, Mao C, Walker BD, Goulder PJJournal of virologyComprehensive screening reveals strong and broadly directed human immunodeficiency virus type 1-specific CD8 responses in perinatally infected children. J Virol. 2003 Jul; 77(13):7492-501.J Virol2003-07-01T00:00:002003Comprehensive screening reveals strong and broadly directed human immunodeficiency virus type 1-specific CD8 responses in perinatally infected children.15067312Deeks SG, Walker BDThe Journal of clinical investigationThe immune response to AIDS virus infection: good, bad, or both? J Clin Invest. 2004 Mar; 113(6):808-10.J Clin Invest2004-03-01T00:00:002004The immune response to AIDS virus infection: good, bad, or both?15199314Lichterfeld M, Yu XG, Cohen D, Addo MM, Malenfant J, Perkins B, Pae E, Johnston MN, Strick D, Allen TM, Rosenberg ES, Korber B, Walker BD, Altfeld MAIDS (London, England)HIV-1 Nef is preferentially recognized by CD8 T cells in primary HIV-1 infection despite a relatively high degree of genetic diversity. AIDS. 2004 Jul 02; 18(10):1383-92.AIDS2004-07-02T00:00:002004HIV-1 Nef is preferentially recognized by CD8 T cells in primary HIV-1 infection despite a relatively high degree of genetic diversity.16182382Brockman MA, Tanzi GO, Walker BD, Allen TMJournal of virological methodsUse of a novel GFP reporter cell line to examine replication capacity of CXCR4- and CCR5-tropic HIV-1 by flow cytometry. J Virol Methods. 2006 Feb; 131(2):134-42.J Virol Methods2005-09-22T00:00:002005Use of a novel GFP reporter cell line to examine replication capacity of CXCR4- and CCR5-tropic HIV-1 by flow cytometry.Authorship 1091781416777397Brander C, Frahm N, Walker BDCurrent opinion in immunologyThe challenges of host and viral diversity in HIV vaccine design. Curr Opin Immunol. 2006 Aug; 18(4):430-7.Curr Opin Immunol2006-06-13T00:00:002006The challenges of host and viral diversity in HIV vaccine design.16982909Leslie A, Price DA, Mkhize P, Bishop K, Rathod A, Day C, Crawford H, Honeyborne I, Asher TE, Luzzi G, Edwards A, Rousseau CM, Rosseau CM, Mullins JI, Tudor-Williams G, Novelli V, Brander C, Douek DC, Kiepiela P, Walker BD, Goulder PJJournal of immunology (Baltimore, Md. : 1950)Differential selection pressure exerted on HIV by CTL targeting identical epitopes but restricted by distinct HLA alleles from the same HLA supertype. J Immunol. 2006 Oct 01; 177(7):4699-708.J Immunol2006-10-01T00:00:002006Differential selection pressure exerted on HIV by CTL targeting identical epitopes but restricted by distinct HLA alleles from the same HLA supertype.17121793Yu XG, Lichterfeld M, Chetty S, Williams KL, Mui SK, Miura T, Frahm N, Feeney ME, Tang Y, Pereyra F, Labute MX, Pfafferott K, Leslie A, Crawford H, Allgaier R, Hildebrand W, Kaslow R, Brander C, Allen TM, Rosenberg ES, Kiepiela P, Vajpayee M, Goepfert PA, Altfeld M, Goulder PJ, Walker BDJournal of virologyMutually exclusive T-cell receptor induction and differential susceptibility to human immunodeficiency virus type 1 mutational escape associated with a two-amino-acid difference between HLA class I subtypes. J Virol. 2007 Feb; 81(4):1619-31.J Virol2006-11-22T00:00:002006Mutually exclusive T-cell receptor induction and differential susceptibility to human immunodeficiency virus type 1 mutational escape associated with a two-amino-acid difference between HLA class I subtypes.17496894Martin MP, Qi Y, Gao X, Yamada E, Martin JN, Pereyra F, Colombo S, Brown EE, Shupert WL, Phair J, Goedert JJ, Buchbinder S, Kirk GD, Telenti A, Connors M, O'Brien SJ, Walker BD, Parham P, Deeks SG, McVicar DW, Carrington MNature geneticsInnate partnership of HLA-B and KIR3DL1 subtypes against HIV-1. Nat Genet. 2007 Jun; 39(6):733-40.Nat Genet2007-05-13T00:00:002007Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1.18181699Dong K, Thabethe Z, Hurtado R, Sibaya T, Dlwati H, Walker B, Wilson DThe Journal of infectious diseasesChallenges to the success of HIV and tuberculosis care and treatment in the public health sector in South Africa. J Infect Dis. 2007 Dec 01; 196 Suppl 3:S491-6.J Infect Dis2007-12-01T00:00:002007Challenges to the success of HIV and tuberculosis care and treatment in the public health sector in South Africa.18473787Zhuang Y, Sun Y, Zhai S, Huang D, Zhao S, Wang S, Kang W, Li X, Walker BD, Altfeld M, Yu XGCurrent HIV researchRelative dominance of Env-gp41-specific cytotoxic T lymphocytes responses in HIV-1 advanced infection. Curr HIV Res. 2008 May; 6(3):239-45.Curr HIV Res2008-05-01T00:00:002008Relative dominance of Env-gp41-specific cytotoxic T lymphocytes responses in HIV-1 advanced infection.Authorship 115385620213861Miura T, Ngumbela K, Ramduth D, Pereyra F, Walker BIAVI report : newsletter on international AIDS vaccine researchHIV controllers. IAVI Rep. 2007 May-Jun; 11(3):1, 7-10.IAVI Rep2007-05-01T00:00:002007HIV controllers.21051598Pereyra F, Jia X, McLaren PJ, Telenti A, de Bakker PI, Walker BD, Ripke S, Brumme CJ, Pulit SL, Carrington M, Kadie CM, Carlson JM, Heckerman D, Graham RR, Plenge RM, Deeks SG, Gianniny L, Crawford G, Sullivan J, Gonzalez E, Davies L, Camargo A, Moore JM, Beattie N, Gupta S, Crenshaw A, Burtt NP, Guiducci C, Gupta N, Gao X, Qi Y, Yuki Y, Piechocka-Trocha A, Cutrell E, Rosenberg R, Moss KL, Lemay P, O'Leary J, Schaefer T, Verma P, Toth I, Block B, Baker B, Rothchild A, Lian J, Proudfoot J, Alvino DM, Vine S, Addo MM, Allen TM, Altfeld M, Henn MR, Le Gall S, Streeck H, Haas DW, Kuritzkes DR, Robbins GK, Shafer RW, Gulick RM, Shikuma CM, Haubrich R, Riddler S, Sax PE, Daar ES, Ribaudo HJ, Agan B, Agarwal S, Ahern RL, Allen BL, Altidor S, Altschuler EL, Ambardar S, Anastos K, Anderson B, Anderson V, Andrady U, Antoniskis D, Bangsberg D, Barbaro D, Barrie W, Bartczak J, Barton S, Basden P, Basgoz N, Bazner S, Bellos NC, Benson AM, Berger J, Bernard NF, Bernard AM, Birch C, Bodner SJ, Bolan RK, Boudreaux ET, Bradley M, Braun JF, Brndjar JE, Brown SJ, Brown K, Brown ST, Burack J, Bush LM, Cafaro V, Campbell O, Campbell J, Carlson RH, Carmichael JK, Casey KK, Cavacuiti C, Celestin G, Chambers ST, Chez N, Chirch LM, Cimoch PJ, Cohen D, Cohn LE, Conway B, Cooper DA, Cornelson B, Cox DT, Cristofano MV, Cuchural G, Czartoski JL, Dahman JM, Daly JS, Davis BT, Davis K, Davod SM, DeJesus E, Dietz CA, Dunham E, Dunn ME, Ellerin TB, Eron JJ, Fangman JJ, Farel CE, Ferlazzo H, Fidler S, Fleenor-Ford A, Frankel R, Freedberg KA, French NK, Fuchs JD, Fuller JD, Gaberman J, Gallant JE, Gandhi RT, Garcia E, Garmon D, Gathe JC, Gaultier CR, Gebre W, Gilman FD, Gilson I, Goepfert PA, Gottlieb MS, Goulston C, Groger RK, Gurley TD, Haber S, Hardwicke R, Hardy WD, Harrigan PR, Hawkins TN, Heath S, Hecht FM, Henry WK, Hladek M, Hoffman RP, Horton JM, Hsu RK, Huhn GD, Hunt P, Hupert MJ, Illeman ML, Jaeger H, Jellinger RM, John M, Johnson JA, Johnson KL, Johnson H, Johnson K, Joly J, Jordan WC, Kauffman CA, Khanlou H, Killian RK, Kim AY, Kim DD, Kinder CA, Kirchner JT, Kogelman L, Kojic EM, Korthuis PT, Kurisu W, Kwon DS, LaMar M, Lampiris H, Lanzafame M, Lederman MM, Lee DM, Lee JM, Lee MJ, Lee ET, Lemoine J, Levy JA, Llibre JM, Liguori MA, Little SJ, Liu AY, Lopez AJ, Loutfy MR, Loy D, Mohammed DY, Man A, Mansour MK, Marconi VC, Markowitz M, Marques R, Martin JN, Martin HL, Mayer KH, McElrath MJ, McGhee TA, McGovern BH, McGowan K, McIntyre D, Mcleod GX, Menezes P, Mesa G, Metroka CE, Meyer-Olson D, Miller AO, Montgomery K, Mounzer KC, Nagami EH, Nagin I, Nahass RG, Nelson MO, Nielsen C, Norene DL, O'Connor DH, Ojikutu BO, Okulicz J, Oladehin OO, Oldfield EC, Olender SA, Ostrowski M, Owen WF, Pae E, Parsonnet J, Pavlatos AM, Perlmutter AM, Pierce MN, Pincus JM, Pisani L, Price LJ, Proia L, Prokesch RC, Pujet HC, Ramgopal M, Rathod A, Rausch M, Ravishankar J, Rhame FS, Richards CS, Richman DD, Rodes B, Rodriguez M, Rose RC, Rosenberg ES, Rosenthal D, Ross PE, Rubin DS, Rumbaugh E, Saenz L, Salvaggio MR, Sanchez WC, Sanjana VM, Santiago S, Schmidt W, Schuitemaker H, Sestak PM, Shalit P, Shay W, Shirvani VN, Silebi VI, Sizemore JM, Skolnik PR, Sokol-Anderson M, Sosman JM, Stabile P, Stapleton JT, Starrett S, Stein F, Stellbrink HJ, Sterman FL, Stone VE, Stone DR, Tambussi G, Taplitz RA, Tedaldi EM, Telenti A, Theisen W, Torres R, Tosiello L, Tremblay C, Tribble MA, Trinh PD, Tsao A, Ueda P, Vaccaro A, Valadas E, Vanig TJ, Vecino I, Vega VM, Veikley W, Wade BH, Walworth C, Wanidworanun C, Ward DJ, Warner DA, Weber RD, Webster D, Weis S, Wheeler DA, White DJ, Wilkins E, Winston A, Wlodaver CG, van't Wout A, Wright DP, Yang OO, Yurdin DL, Zabukovic BW, Zachary KC, Zeeman B, Zhao MScience (New York, N.Y.)The major genetic determinants of HIV-1 control affect HLA class I peptide presentation. Science. 2010 Dec 10; 330(6010):1551-7.Science2010-11-04T00:00:002010The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.21124229Brumme ZL, Li C, Miura T, Sela J, Rosato PC, Brumme CJ, Markle TJ, Martin E, Block BL, Trocha A, Kadie CM, Allen TM, Pereyra F, Heckerman D, Walker BD, Brockman MAJournal of acquired immune deficiency syndromes (1999)Reduced replication capacity of NL4-3 recombinant viruses encoding reverse transcriptase-integrase sequences from HIV-1 elite controllers. J Acquir Immune Defic Syndr. 2011 Feb 01; 56(2):100-8.J Acquir Immune Defic Syndr2011-02-01T00:00:002011Reduced replication capacity of NL4-3 recombinant viruses encoding reverse transcriptase-integrase sequences from HIV-1 elite controllers.22090116Wright JK, Brumme ZL, Julg B, van der Stok M, Mncube Z, Gao X, Carlson JM, Goulder PJ, Walker BD, Brockman MA, Ndung'u TJournal of virologyLack of association between HLA class II alleles and in vitro replication capacities of recombinant viruses encoding HIV-1 subtype C Gag-protease from chronically infected individuals. J Virol. 2012 Jan; 86(2):1273-6.J Virol2011-11-16T00:00:002011Lack of association between HLA class II alleles and in vitro replication capacities of recombinant viruses encoding HIV-1 subtype C Gag-protease from chronically infected individuals.22826297Klein F, Gaebler C, Mouquet H, Sather DN, Lehmann C, Scheid JF, Kraft Z, Liu Y, Pietzsch J, Hurley A, Poignard P, Feizi T, Morris L, Walker BD, Fätkenheuer G, Seaman MS, Stamatatos L, Nussenzweig MCThe Journal of experimental medicineBroad neutralization by a combination of antibodies recognizing the CD4 binding site and a new conformational epitope on the HIV-1 envelope protein. J Exp Med. 2012 Jul 30; 209(8):1469-79.J Exp Med2012-07-23T00:00:002012Broad neutralization by a combination of antibodies recognizing the CD4 binding site and a new conformational epitope on the HIV-1 envelope protein.23084910Burton DR, Ahmed R, Barouch DH, Butera ST, Crotty S, Godzik A, Kaufmann DE, McElrath MJ, Nussenzweig MC, Pulendran B, Scanlan CN, Schief WR, Silvestri G, Streeck H, Walker BD, Walker LM, Ward AB, Wilson IA, Wyatt RCell host & microbeA Blueprint for HIV Vaccine Discovery. Cell Host Microbe. 2012 Oct 18; 12(4):396-407.Cell Host Microbe2012-10-18T00:00:002012A Blueprint for HIV Vaccine Discovery.23521886Ferguson AL, Mann JK, Omarjee S, Ndung'u T, Walker BD, Chakraborty AKImmunityTranslating HIV sequences into quantitative fitness landscapes predicts viral vulnerabilities for rational immunogen design. Immunity. 2013 Mar 21; 38(3):606-17.Immunity2013-03-21T00:00:002013Translating HIV sequences into quantitative fitness landscapes predicts viral vulnerabilities for rational immunogen design.8182510Walker BDJournal of acquired immune deficiency syndromesThe rationale for immunotherapy in HIV-1 infection. J Acquir Immune Defic Syndr (1988). 1994; 7 Suppl 1:S6-13.J Acquir Immune Defic Syndr (1988)1994-01-01T00:00:001994The rationale for immunotherapy in HIV-1 infection.9343219Cao H, Kanki P, Sankalé JL, Dieng-Sarr A, Mazzara GP, Kalams SA, Korber B, Mboup S, Walker BDJournal of virologyCytotoxic T-lymphocyte cross-reactivity among different human immunodeficiency virus type 1 clades: implications for vaccine development. J Virol. 1997 Nov; 71(11):8615-23.J Virol1997-11-01T00:00:001997Cytotoxic T-lymphocyte cross-reactivity among different human immunodeficiency virus type 1 clades: implications for vaccine development.9570570Wong DK, Dudley DD, Afdhal NH, Dienstag J, Rice CM, Wang L, Houghton M, Walker BD, Koziel MJJournal of immunology (Baltimore, Md. : 1950)Liver-derived CTL in hepatitis C virus infection: breadth and specificity of responses in a cohort of persons with chronic infection. J Immunol. 1998 Feb 01; 160(3):1479-88.J Immunol1998-02-01T00:00:001998Liver-derived CTL in hepatitis C virus infection: breadth and specificity of responses in a cohort of persons with chronic infection.Authorship 1127881512088684Gandhi RT, Walker BDCurrent opinion in immunologyPromises and pitfalls in the reconstitution of immunity in patients who have HIV-1 infection. Curr Opin Immunol. 2002 Aug; 14(4):487-94.Curr Opin Immunol2002-08-01T00:00:002002Promises and pitfalls in the reconstitution of immunity in patients who have HIV-1 infection.12667667Draenert R, Altfeld M, Brander C, Basgoz N, Corcoran C, Wurcel AG, Stone DR, Kalams SA, Trocha A, Addo MM, Goulder PJ, Walker BDJournal of immunological methodsComparison of overlapping peptide sets for detection of antiviral CD8 and CD4 T cell responses. J Immunol Methods. 2003 Apr 01; 275(1-2):19-29.J Immunol Methods2003-04-01T00:00:002003Comparison of overlapping peptide sets for detection of antiviral CD8 and CD4 T cell responses.16051815Frahm N, Adams S, Kiepiela P, Linde CH, Hewitt HS, Lichterfeld M, Sango K, Brown NV, Pae E, Wurcel AG, Altfeld M, Feeney ME, Allen TM, Roach T, St John MA, Daar ES, Rosenberg E, Korber B, Marincola F, Walker BD, Goulder PJ, Brander CJournal of virologyHLA-B63 presents HLA-B57/B58-restricted cytotoxic T-lymphocyte epitopes and is associated with low human immunodeficiency virus load. J Virol. 2005 Aug; 79(16):10218-25.J Virol2005-08-01T00:00:002005HLA-B63 presents HLA-B57/B58-restricted cytotoxic T-lymphocyte epitopes and is associated with low human immunodeficiency virus load.16135897Yu XG, Lichterfeld M, Perkins B, Kalife E, Mui S, Chen J, Cheng M, Kang W, Alter G, Brander C, Walker BD, Altfeld MAIDS (London, England)High degree of inter-clade cross-reactivity of HIV-1-specific T cell responses at the single peptide level. AIDS. 2005 Sep 23; 19(14):1449-56.AIDS2005-09-23T00:00:002005High degree of inter-clade cross-reactivity of HIV-1-specific T cell responses at the single peptide level.16547245Bihl F, Frahm N, Di Giammarino L, Sidney J, John M, Yusim K, Woodberry T, Sango K, Hewitt HS, Henry L, Linde CH, Chisholm JV, Zaman TM, Pae E, Mallal S, Walker BD, Sette A, Korber BT, Heckerman D, Brander CJournal of immunology (Baltimore, Md. : 1950)Impact of HLA-B alleles, epitope binding affinity, functional avidity, and viral coinfection on the immunodominance of virus-specific CTL responses. J Immunol. 2006 Apr 01; 176(7):4094-101.J Immunol2006-04-01T00:00:002006Impact of HLA-B alleles, epitope binding affinity, functional avidity, and viral coinfection on the immunodominance of virus-specific CTL responses.17314156Rousseau CM, Learn GH, Bhattacharya T, Nickle DC, Heckerman D, Chetty S, Brander C, Goulder PJ, Walker BD, Kiepiela P, Korber BT, Mullins JIJournal of virologyExtensive intrasubtype recombination in South African human immunodeficiency virus type 1 subtype C infections. J Virol. 2007 May; 81(9):4492-500.J Virol2007-02-21T00:00:002007Extensive intrasubtype recombination in South African human immunodeficiency virus type 1 subtype C infections.18246203Kasprowicz V, Ward SM, Turner A, Grammatikos A, Nolan BE, Lewis-Ximenez L, Sharp C, Woodruff J, Fleming VM, Sims S, Walker BD, Sewell AK, Lauer GM, Klenerman PThe Journal of clinical investigationDefining the directionality and quality of influenza virus-specific CD8+ T cell cross-reactivity in individuals infected with hepatitis C virus. J Clin Invest. 2008 Mar; 118(3):1143-53.J Clin Invest2008-03-01T00:00:002008Defining the directionality and quality of influenza virus-specific CD8+ T cell cross-reactivity in individuals infected with hepatitis C virus.18419535Day CL, Mkhwanazi N, Reddy S, Mncube Z, van der Stok M, Klenerman P, Walker BDThe Journal of infectious diseasesDetection of polyfunctional Mycobacterium tuberculosis-specific T cells and association with viral load in HIV-1-infected persons. J Infect Dis. 2008 Apr 01; 197(7):990-9.J Infect Dis2008-04-01T00:00:002008Detection of polyfunctional Mycobacterium tuberculosis-specific T cells and association with viral load in HIV-1-infected persons.20045101Ferreira MA, Mangino M, Brumme CJ, Zhao ZZ, Medland SE, Wright MJ, Nyholt DR, Gordon S, Campbell M, McEvoy BP, Henders A, Evans DM, Lanchbury JS, Pereyra F, Walker BD, Haas DW, Soranzo N, Spector TD, de Bakker PI, Frazer IH, Montgomery GW, Martin NGAmerican journal of human geneticsQuantitative trait loci for CD4:CD8 lymphocyte ratio are associated with risk of type 1 diabetes and HIV-1 immune control. Am J Hum Genet. 2010 Jan; 86(1):88-92.Am J Hum Genet2009-12-31T00:00:002009Quantitative trait loci for CD4:CD8 lymphocyte ratio are associated with risk of type 1 diabetes and HIV-1 immune control.20377426Banerjee K, Klasse PJ, Sanders RW, Pereyra F, Michael E, Lu M, Walker BD, Moore JPAIDS research and human retrovirusesIgG subclass profiles in infected HIV type 1 controllers and chronic progressors and in uninfected recipients of Env vaccines. AIDS Res Hum Retroviruses. 2010 Apr; 26(4):445-58.AIDS Res Hum Retroviruses2010-04-01T00:00:002010IgG subclass profiles in infected HIV type 1 controllers and chronic progressors and in uninfected recipients of Env vaccines.21690407Dahirel V, Shekhar K, Pereyra F, Miura T, Artyomov M, Talsania S, Allen TM, Altfeld M, Carrington M, Irvine DJ, Walker BD, Chakraborty AKProceedings of the National Academy of Sciences of the United States of AmericaCoordinate linkage of HIV evolution reveals regions of immunological vulnerability. Proc Natl Acad Sci U S A. 2011 Jul 12; 108(28):11530-5.Proc Natl Acad Sci U S A2011-06-20T00:00:002011Coordinate linkage of HIV evolution reveals regions of immunological vulnerability.22248321Carrington M, Walker BDAnnual review of medicineImmunogenetics of spontaneous control of HIV. Annu Rev Med. 2012; 63:131-45.Annu Rev Med2012-01-01T00:00:002012Immunogenetics of spontaneous control of HIV.Rolland M, Heckerman D, Deng W, Rousseau CM, Coovadia H, Bishop K, Goulder PJ, Walker BD, Brander C, Mullins JIPLoS OneBroad and Gag baised HIV – 1 epitopeprepertoires are associated with lower viral loads. PLoS One. 2008; 3(1):e1424.2008-01-09T00:00:002008Broad and Gag baised HIV – 1 epitopeprepertoires are associated with lower viral loadsWilson C, Wong JT, Girard DD, Merrill DP, Dynan M, An DD, Kalams SA, Johnson RP, Hirsch MS, D'Aquila RT, Walker BDJ Infect DisEx vivo expansion of CD4 lymphocytes from human immunodeficiency virus type 1-infected persons in the presence of combination antiretroviral agents. J Infect Dis. 1995; 172:88-96.1995-01-01T00:00:001995Ex vivo expansion of CD4 lymphocytes from human immunodeficiency virus type 1-infected persons in the presence of combination antiretroviral agents7583437Heinkelein M, Schneider-Schaulies J, Walker BD, Jassoy CJournal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology AssociationInhibition of cytotoxicity and cytokine release of CD8+ HIV-specific cytotoxic T lymphocytes by pentoxifylline. J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Dec 01; 10(4):417-24.J Acquir Immune Defic Syndr Hum Retrovirol1995-12-01T00:00:001995Inhibition of cytotoxicity and cytokine release of CD8+ HIV-specific cytotoxic T lymphocytes by pentoxifylline.Authorship 121136130885693Julg B, Dee L, Ananworanich J, Barouch DH, Bar K, Caskey M, Colby DJ, Dawson L, Dong KL, Dubé K, Eron J, Frater J, Gandhi RT, Geleziunas R, Goulder P, Hanna GJ, Jefferys R, Johnston R, Kuritzkes D, Li JZ, Likhitwonnawut U, van Lunzen J, Martinez-Picado J, Miller V, Montaner LJ, Nixon DF, Palm D, Pantaleo G, Peay H, Persaud D, Salzwedel J, Salzwedel K, Schacker T, Sheikh V, Søgaard OS, Spudich S, Stephenson K, Sugarman J, Taylor J, Tebas P, Tiemessen CT, Tressler R, Weiss CD, Zheng L, Robb ML, Michael NL, Mellors JW, Deeks SG, Walker BDThe lancet. HIVRecommendations for analytical antiretroviral treatment interruptions in HIV research trials-report of a consensus meeting. Lancet HIV. 2019 04; 6(4):e259-e268.Lancet HIV2019-03-15T00:00:002019Recommendations for analytical antiretroviral treatment interruptions in HIV research trials-report of a consensus meeting.D018984Chemicals & Drugs2928770.717705Epitopes, T-LymphocyteAuthorship 11768415D015497Living Beings83469310.277707HIV-1Authorship 114029049D013602Anatomy58918220.571508T-Lymphocytes, CytotoxicAuthorship 11423209Authorship 11433011130964004Gonzalo-Gil E, Rapuano PB, Ikediobi U, Leibowitz R, Mehta S, Coskun AK, Porterfield JZ, Lampkin TD, Marconi VC, Rimland D, Walker BD, Deeks S, Sutton REeLifeTranscriptional down-regulation of ccr5 in a subset of HIV+ controllers and their family members. Elife. 2019 04 09; 8.Elife2019-04-09T00:00:002019Transcriptional down-regulation of ccr5 in a subset of HIV+ controllers and their family members.30943397Monel B, McKeon A, Lamothe-Molina P, Jani P, Boucau J, Pacheco Y, Jones RB, Le Gall S, Walker BDCell reportsHIV Controllers Exhibit Effective CD8+ T Cell Recognition of HIV-1-Infected Non-activated CD4+ T Cells. Cell Rep. 2019 04 02; 27(1):142-153.e4.Cell Rep2019-04-02T00:00:002019HIV Controllers Exhibit Effective CD8+ T Cell Recognition of HIV-1-Infected Non-activated CD4+ T Cells.D015658Disorders1931167640.15209HIV InfectionsAuthorship 11509001831048489Gaiha GD, Rossin EJ, Urbach J, Landeros C, Collins DR, Nwonu C, Muzhingi I, Anahtar MN, Waring OM, Piechocka-Trocha A, Waring M, Worrall DP, Ghebremichael MS, Newman RM, Power KA, Allen TM, Chodosh J, Walker BDScience (New York, N.Y.)Structural topology defines protective CD8+ T cell epitopes in the HIV proteome. Science. 2019 05 03; 364(6439):480-484.Science2019-05-03T00:00:002019Structural topology defines protective CD8+ T cell epitopes in the HIV proteome.D018414Anatomy137544240.370362CD8-Positive T-LymphocytesMedicinePathologyGastroenterologyInfectious DiseaseVaccine ResearchBeth Israel Deaconess Medical CenterBrigham and Women's HospitalDana-Farber Cancer InstituteMassachusetts General HospitalKHM2KennethMayerKenneth Hugh Mayer, M.D.42.34652700000000-71.0878720000000068578Mayer, KennethProfessor of MedicineKristaDongKrista Louise Dong, M.D.42.37730000000000-71.0525000000000034982Dong, KristaMember of the Faculty of MedicineAuthorship 11563001431118290Ndhlovu ZM, Kazer SW, Nkosi T, Ogunshola F, Muema DM, Anmole G, Swann SA, Moodley A, Dong K, Reddy T, Brockman MA, Shalek AK, Ndung'u T, Walker BDScience translational medicineAugmentation of HIV-specific T cell function by immediate treatment of hyperacute HIV-1 infection. Sci Transl Med. 2019 05 22; 11(493).Sci Transl Med2019-05-22T00:00:002019Augmentation of HIV-specific T cell function by immediate treatment of hyperacute HIV-1 infection.ZMN1ZazaNdhlovuZaza Mtine Ndhlovu, Ph.D.42.37730000000000-71.0525000000000038891Ndhlovu, ZazaAssistant Professor of Medicine, Part-timeAuthorship 1385621111668selected publications15.09640.00276721020research areas4.553450.0102531209coauthor of614.94885.698260similar toDHB3DanBarouchDan Hung Barouch, M.D.42.34022770000000-71.1058540000000028268Barouch, DanWilliam Bosworth Castle Professor of MedicineML79MathiasLichterfeldMathias Lichterfeld, M.D., Ph.D.42.37730000000000-71.0525000000000043487Lichterfeld, MathiasProfessor of MedicineESR2EricRosenbergEric Scott Rosenberg, M.D.42.36241700000000-71.0689370000000065644Rosenberg, EricProfessor of PathologyGA25GalitAlterGalit Alter, Ph.D.42.37730000000000-71.0525000000000083846Alter, GalitProfessor of Medicine (on leave)JGS10JosephSodroskiJoseph Gerard Sodroski, M.D.42.33789600000000-71.1072493000000042351Sodroski, JosephProfessor of MicrobiologyYX7XuYuXu Yu, M.D.42.37730000000000-71.0525000000000032729Yu, XuProfessor of MedicineAuthorship 1160544731227699Lee GQ, Reddy K, Einkauf KB, Gounder K, Chevalier JM, Dong KL, Walker BD, Yu XG, Ndung'u T, Lichterfeld MNature communicationsHIV-1 DNA sequence diversity and evolution during acute subtype C infection. Nat Commun. 2019 06 21; 10(1):2737.Nat Commun2019-06-21T00:00:002019HIV-1 DNA sequence diversity and evolution during acute subtype C infection.GDG6GauravGaihaGaurav Das Gaiha, M.D.32180Gaiha, GauravAssistant Professor of MedicineTA15ToddAllenTodd Allen, Ph.D.42.37730000000000-71.0525000000000081018Allen, ToddProfessor of MedicineDRK3DanielKuritzkesDaniel Robert Kuritzkes, M.D.42.36070000000000-71.1009000000000062664Kuritzkes, DanielHarriet Ryan Albee Professor of MedicineAuthorship 13069815Authorship 136109Authorship 13291616Authorship 12575318Authorship 1443186Authorship 1193040431552045Mylvaganam G, Yanez AG, Maus M, Walker BDFrontiers in immunologyToward T Cell-Mediated Control or Elimination of HIV Reservoirs: Lessons From Cancer Immunology. Front Immunol. 2019; 10:2109.Front Immunol2019-09-10T00:00:002019Toward T Cell-Mediated Control or Elimination of HIV Reservoirs: Lessons From Cancer Immunology.Authorship 14652911Authorship 1471637Authorship 1534711Authorship 1202012731693887Jin SW, Alsahafi N, Kuang XT, Swann SA, Toyoda M, Göttlinger H, Walker BD, Ueno T, Finzi A, Brumme ZL, Brockman MACell reportsNatural HIV-1 Nef Polymorphisms Impair SERINC5 Downregulation Activity. Cell Rep. 2019 11 05; 29(6):1449-1457.e5.Cell Rep2019-11-05T00:00:002019Natural HIV-1 Nef Polymorphisms Impair SERINC5 Downregulation Activity.true1Professor of PathologyProfessor of Pathologytrue1Professor of MedicineProfessor of Medicinetrue1Professor of MicrobiologyProfessor of Microbiologytrue1Assistant Professor of Medicine, Part-timeAssistant Professor of Medicine, Part-timetrue1Harriet Ryan Albee Professor of MedicineHarriet Ryan Albee Professor of MedicineAuthorship 1249804Authorship 1251304Authorship 14475311Authorship 12871982024-11-30WALKER, BRUCE D2019-12-23Understanding and Reversing T Cell Dysfunction to Control and Eliminate Persistent HIV ReservoirsR01AI149704Principal InvestigatorAuthorship 1535129Authorship 1221980831995767Martin-Gayo E, Gao C, Chen HR, Ouyang Z, Kim D, Kolb KE, Shalek AK, Walker BD, Lichterfeld M, Yu XGCell reportsImmunological Fingerprints of Controllers Developing Neutralizing HIV-1 Antibodies. Cell Rep. 2020 01 28; 30(4):984-996.e4.Cell Rep2020-01-28T00:00:002020Immunological Fingerprints of Controllers Developing Neutralizing HIV-1 Antibodies.Authorship 1200247Authorship 1211332Authorship 16176416Authorship 1225955332051540Collins DR, Gaiha GD, Walker BDNature reviews. ImmunologyCD8+ T cells in HIV control, cure and prevention. Nat Rev Immunol. 2020 08; 20(8):471-482.Nat Rev Immunol2020-02-12T00:00:002020CD8+ T cells in HIV control, cure and prevention.Authorship 12951528Authorship 12270011Authorship 17814913Authorship 12358581332209092Muema DM, Akilimali NA, Ndumnego OC, Rasehlo SS, Durgiah R, Ojwach DBA, Ismail N, Dong M, Moodley A, Dong KL, Ndhlovu ZM, Mabuka JM, Walker BD, Mann JK, Ndung'u TBMC medicineAssociation between the cytokine storm, immune cell dynamics, and viral replicative capacity in hyperacute HIV infection. BMC Med. 2020 03 25; 18(1):81.BMC Med2020-03-25T00:00:002020Association between the cytokine storm, immune cell dynamics, and viral replicative capacity in hyperacute HIV infection.Authorship 17593516Authorship 1236744832238952Bucur O, Fu F, Calderon M, Mylvaganam GH, Ly NL, Day J, Watkin S, Walker BD, Boyden ES, Zhao YNature protocolsNanoscale imaging of clinical specimens using conventional and rapid-expansion pathology. Nat Protoc. 2020 05; 15(5):1649-1672.Nat Protoc2020-04-01T00:00:002020Nanoscale imaging of clinical specimens using conventional and rapid-expansion pathology.Authorship 123911120Authorship 1238433832251406Kazer SW, Aicher TP, Muema DM, Carroll SL, Ordovas-Montanes J, Miao VN, Tu AA, Ziegler CGK, Nyquist SK, Wong EB, Ismail N, Dong M, Moodley A, Berger B, Love JC, Dong KL, Leslie A, Ndhlovu ZM, Ndung'u T, Walker BD, Shalek AKNature medicineIntegrated single-cell analysis of multicellular immune dynamics during hyperacute HIV-1 infection. Nat Med. 2020 04; 26(4):511-518.Nat Med2020-03-23T00:00:002020Integrated single-cell analysis of multicellular immune dynamics during hyperacute HIV-1 infection.32275203Ndlovu B, Gounder K, Muema D, Raju N, Hermanus T, Mthethwa Q, Robertson K, Walker BD, Georgiev IS, Morris L, Moore PL, Ndung'u TVirologyEnvelope characteristics in individuals who developed neutralizing antibodies targeting different epitopes in HIV-1 subtype C infection. Virology. 2020 07; 546:1-12.Virology2020-03-25T00:00:002020Envelope characteristics in individuals who developed neutralizing antibodies targeting different epitopes in HIV-1 subtype C infection.Authorship 177042Authorship 125704416Authorship 12558071032510047Millar JR, Bengu N, Fillis R, Sprenger K, Ntlantsana V, Vieira VA, Khambati N, Archary M, Muenchhoff M, Groll A, Grayson N, Adamson J, Govender K, Dong K, Kiepiela P, Walker BD, Bonsall D, Connor T, Bull MJ, Nxele N, Roider J, Ismail N, Adland E, Puertas MC, Martinez-Picado J, Matthews PC, Ndung'u T, Goulder PEClinicalMedicineHIGH-FREQUENCY failure of combination antiretroviral therapy in paediatric HIV infection is associated with unmet maternal needs causing maternal NON-ADHERENCE. EClinicalMedicine. 2020 May; 22:100344.EClinicalMedicine2020-05-08T00:00:002020HIGH-FREQUENCY failure of combination antiretroviral therapy in paediatric HIV infection is associated with unmet maternal needs causing maternal NON-ADHERENCE.32511521Joung J, Ladha A, Saito M, Segel M, Bruneau R, Huang MW, Kim NG, Yu X, Li J, Walker BD, Greninger AL, Jerome KR, Gootenberg JS, Abudayyeh OO, Zhang FmedRxiv : the preprint server for health sciencesPoint-of-care testing for COVID-19 using SHERLOCK diagnostics. medRxiv. 2020 May 08.medRxiv2020-05-08T00:00:002020Point-of-care testing for COVID-19 using SHERLOCK diagnostics.Authorship 1368814Authorship 1592784Authorship 1409757Authorship 1667762Authorship 12749314732742244Kaneko N, Kuo HH, Boucau J, Farmer JR, Allard-Chamard H, Mahajan VS, Piechocka-Trocha A, Lefteri K, Osborn M, Bals J, Bartsch YC, Bonheur N, Caradonna TM, Chevalier J, Chowdhury F, Diefenbach TJ, Einkauf K, Fallon J, Feldman J, Finn KK, Garcia-Broncano P, Hartana CA, Hauser BM, Jiang C, Kaplonek P, Karpell M, Koscher EC, Lian X, Liu H, Liu J, Ly NL, Michell AR, Rassadkina Y, Seiger K, Sessa L, Shin S, Singh N, Sun W, Sun X, Ticheli HJ, Waring MT, Zhu AL, Li J, Lingwood D, Schmidt AG, Lichterfeld M, Walker BD, Yu X, Padera RF, Pillai SSSRNThe Loss of Bcl-6 Expressing T Follicular Helper Cells and the Absence of Germinal Centers in COVID-19. SSRN. 2020 Jul 16; 3652322.SSRN2020-07-16T00:00:002020The Loss of Bcl-6 Expressing T Follicular Helper Cells and the Absence of Germinal Centers in COVID-19.Authorship 1944367Authorship 18916015Authorship 12796702932848246Jiang C, Lian X, Gao C, Sun X, Einkauf KB, Chevalier JM, Chen SMY, Hua S, Rhee B, Chang K, Blackmer JE, Osborn M, Peluso MJ, Hoh R, Somsouk M, Milush J, Bertagnolli LN, Sweet SE, Varriale JA, Burbelo PD, Chun TW, Laird GM, Serrao E, Engelman AN, Carrington M, Siliciano RF, Siliciano JM, Deeks SG, Walker BD, Lichterfeld M, Yu XGNatureDistinct viral reservoirs in individuals with spontaneous control of HIV-1. Nature. 2020 09; 585(7824):261-267.Nature2020-08-26T00:00:002020Distinct viral reservoirs in individuals with spontaneous control of HIV-1.Authorship 12822704832877699Kaneko N, Kuo HH, Boucau J, Farmer JR, Allard-Chamard H, Mahajan VS, Piechocka-Trocha A, Lefteri K, Osborn M, Bals J, Bartsch YC, Bonheur N, Caradonna TM, Chevalier J, Chowdhury F, Diefenbach TJ, Einkauf K, Fallon J, Feldman J, Finn KK, Garcia-Broncano P, Hartana CA, Hauser BM, Jiang C, Kaplonek P, Karpell M, Koscher EC, Lian X, Liu H, Liu J, Ly NL, Michell AR, Rassadkina Y, Seiger K, Sessa L, Shin S, Singh N, Sun W, Sun X, Ticheli HJ, Waring MT, Zhu AL, Alter G, Li JZ, Lingwood D, Schmidt AG, Lichterfeld M, Walker BD, Yu XG, Padera RF, Pillai SCellLoss of Bcl-6-Expressing T Follicular Helper Cells and Germinal Centers in COVID-19. Cell. 2020 10 01; 183(1):143-157.e13.Cell2020-08-19T00:00:002020Loss of Bcl-6-Expressing T Follicular Helper Cells and Germinal Centers in COVID-19.Authorship 128811519Authorship 12882171732937062Joung J, Ladha A, Saito M, Kim NG, Woolley AE, Segel M, Barretto RPJ, Ranu A, Macrae RK, Faure G, Ioannidi EI, Krajeski RN, Bruneau R, Huang MW, Yu XG, Li JZ, Walker BD, Hung DT, Greninger AL, Jerome KR, Gootenberg JS, Abudayyeh OO, Zhang FThe New England journal of medicineDetection of SARS-CoV-2 with SHERLOCK One-Pot Testing. N Engl J Med. 2020 10 08; 383(15):1492-1494.N Engl J Med2020-09-16T00:00:002020Detection of SARS-CoV-2 with SHERLOCK One-Pot Testing.32900948Painter MM, Zimmerman GE, Merlino MS, Robertson AW, Terry VH, Ren X, McLeod MR, Gomez-Rodriguez L, Garcia KA, Leonard JA, Leopold KE, Neevel AJ, Lubow J, Olson E, Piechocka-Trocha A, Collins DR, Tripathi A, Raghavan M, Walker BD, Hurley JH, Sherman DH, Collins KLProceedings of the National Academy of Sciences of the United States of AmericaConcanamycin A counteracts HIV-1 Nef to enhance immune clearance of infected primary cells by cytotoxic T lymphocytes. Proc Natl Acad Sci U S A. 2020 09 22; 117(38):23835-23846.Proc Natl Acad Sci U S A2020-09-08T00:00:002020Concanamycin A counteracts HIV-1 Nef to enhance immune clearance of infected primary cells by cytotoxic T lymphocytes.Authorship 1483432994364Shrock E, Fujimura E, Kula T, Timms RT, Lee IH, Leng Y, Robinson ML, Sie BM, Li MZ, Chen Y, Logue J, Zuiani A, McCulloch D, Lelis FJN, Henson S, Monaco DR, Travers M, Habibi S, Clarke WA, Caturegli P, Laeyendecker O, Piechocka-Trocha A, Li JZ, Khatri A, Chu HY, Villani AC, Kays K, Goldberg MB, Hacohen N, Filbin MR, Yu XG, Walker BD, Wesemann DR, Larman HB, Lederer JA, Elledge SJScience (New York, N.Y.)Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity. Science. 2020 11 27; 370(6520).Science2020-09-29T00:00:002020Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity.Authorship 129221233Authorship 20566733127906Fajnzylber J, Regan J, Coxen K, Corry H, Wong C, Rosenthal A, Worrall D, Giguel F, Piechocka-Trocha A, Atyeo C, Fischinger S, Chan A, Flaherty KT, Hall K, Dougan M, Ryan ET, Gillespie E, Chishti R, Li Y, Jilg N, Hanidziar D, Baron RM, Baden L, Tsibris AM, Armstrong KA, Kuritzkes DR, Alter G, Walker BD, Yu X, Li JZNature communicationsSARS-CoV-2 viral load is associated with increased disease severity and mortality. Nat Commun. 2020 10 30; 11(1):5493.Nat Commun2020-10-30T00:00:002020SARS-CoV-2 viral load is associated with increased disease severity and mortality.Authorship 12998082833176080Choi B, Choudhary MC, Regan J, Sparks JA, Padera RF, Qiu X, Solomon IH, Kuo HH, Boucau J, Bowman K, Adhikari UD, Winkler ML, Mueller AA, Hsu TY, Desjardins M, Baden LR, Chan BT, Walker BD, Lichterfeld M, Brigl M, Kwon DS, Kanjilal S, Richardson ET, Jonsson AH, Alter G, Barczak AK, Hanage WP, Yu XG, Gaiha GD, Seaman MS, Cernadas M, Li JZThe New England journal of medicinePersistence and Evolution of SARS-CoV-2 in an Immunocompromised Host. N Engl J Med. 2020 12 03; 383(23):2291-2293.N Engl J Med2020-11-11T00:00:002020Persistence and Evolution of SARS-CoV-2 in an Immunocompromised Host.Authorship 14022414Authorship 15002510true1Assistant Professor of MedicineAssistant Professor of MedicineAuthorship 13022672Authorship 13024131833207216Kazer SW, Walker BD, Shalek AKImmunityEvolution and Diversity of Immune Responses during Acute HIV Infection. Immunity. 2020 11 17; 53(5):908-924.Immunity2020-11-17T00:00:002020Evolution and Diversity of Immune Responses during Acute HIV Infection.33351086Edlow AG, Li JZ, Collier AY, Atyeo C, James KE, Boatin AA, Gray KJ, Bordt EA, Shook LL, Yonker LM, Fasano A, Diouf K, Croul N, Devane S, Yockey LJ, Lima R, Shui J, Matute JD, Lerou PH, Akinwunmi BO, Schmidt A, Feldman J, Hauser BM, Caradonna TM, De la Flor D, D'Avino P, Regan J, Corry H, Coxen K, Fajnzylber J, Pepin D, Seaman MS, Barouch DH, Walker BD, Yu XG, Kaimal AJ, Roberts DJ, Alter GJAMA network openAssessment of Maternal and Neonatal SARS-CoV-2 Viral Load, Transplacental Antibody Transfer, and Placental Pathology in Pregnancies During the COVID-19 Pandemic. JAMA Netw Open. 2020 12 01; 3(12):e2030455.JAMA Netw Open2020-12-01T00:00:002020Assessment of Maternal and Neonatal SARS-CoV-2 Viral Load, Transplacental Antibody Transfer, and Placental Pathology in Pregnancies During the COVID-19 Pandemic.33330871Galvan-Pena S, Leon J, Chowdhary K, Michelson DA, Vijaykumar B, Yang L, Magnuson A, Manickas-Hill Z, Piechocka-Trocha A, Worrall DP, Hall KE, Ghebremichael M, Walker BD, Li JZ, Yu XG, Mathis D, Benoist CbioRxiv : the preprint server for biologyProfound Treg perturbations correlate with COVID-19 severity. bioRxiv. 2020 Dec 15.bioRxiv2020-12-15T00:00:002020Profound Treg perturbations correlate with COVID-19 severity.Authorship 131013313Authorship 131368534Authorship 132095815Authorship 13227151133450518Garcia-Bates TM, Palma ML, Anderko RR, Hsu DC, Ananworanich J, Korber BT, Gaiha GD, Phanuphak N, Thomas R, Tovanabutra S, Walker BD, Mellors JW, Piazza PA, Kroon E, Riddler SA, Michael NL, Rinaldo CR, Mailliard RBEBioMedicineDendritic cells focus CTL responses toward highly conserved and topologically important HIV-1 epitopes. EBioMedicine. 2021 Jan; 63:103175.EBioMedicine2021-01-12T00:00:002021Dendritic cells focus CTL responses toward highly conserved and topologically important HIV-1 epitopes.33469605Silverstein NJ, Wang Y, Manickas-Hill Z, Carbone C, Dauphin A, Boribong BP, Loiselle M, Davis J, Leonard MM, Kuri-Cervantes L, Meyer NJ, Betts MR, Li JZ, Walker B, Yu XG, Yonker LM, Luban JmedRxiv : the preprint server for health sciencesInnate lymphoid cells and disease tolerance in SARS-CoV-2 infection. medRxiv. 2021 Oct 11.medRxiv2021-10-11T00:00:002021Innate lymphoid cells and disease tolerance in SARS-CoV-2 infection.Authorship 1328920833571449Clayton KL, Mylvaganam G, Villasmil-Ocando A, Stuart H, Maus MV, Rashidian M, Ploegh HL, Walker BDCell host & microbeHIV-infected macrophages resist efficient NK cell-mediated killing while preserving inflammatory cytokine responses. Cell Host Microbe. 2021 03 10; 29(3):435-447.e9.Cell Host Microbe2021-02-10T00:00:002021HIV-infected macrophages resist efficient NK cell-mediated killing while preserving inflammatory cytokine responses.Authorship 1997642Authorship 1960752Authorship 22445514Authorship 1339464133730459Walker BDThe New England journal of medicineThe AMP Trials - A Glass Half Full. N Engl J Med. 2021 03 18; 384(11):1068-1069.N Engl J Med2021-03-18T00:00:002021The AMP Trials - A Glass Half Full.Authorship 13450081333791730Kaneko N, Boucau J, Kuo HH, Perugino C, Mahajan VS, Farmer JR, Liu H, Diefenbach TJ, Piechocka-Trocha A, Lefteri K, Waring MT, Premo KR, Walker BD, Li JZ, Gaiha G, Yu XG, Lichterfeld M, Padera RF, Pillai SmedRxiv : the preprint server for health sciencesExpansion of Cytotoxic CD4+ T cells in the lungs in severe COVID-19. medRxiv. 2021 Mar 26.medRxiv2021-03-26T00:00:002021Expansion of Cytotoxic CD4+ T cells in the lungs in severe COVID-19.Authorship 1619872Authorship 16102714Authorship 18802022Authorship 1352321533938445Hartana CA, Rassadkina Y, Gao C, Martin-Gayo E, Walker BD, Lichterfeld M, Yu XGThe Journal of clinical investigationLong noncoding RNA MIR4435-2HG enhances metabolic function of myeloid dendritic cells from HIV-1 elite controllers. J Clin Invest. 2021 05 03; 131(9).J Clin Invest2021-05-03T00:00:002021Long noncoding RNA MIR4435-2HG enhances metabolic function of myeloid dendritic cells from HIV-1 elite controllers.Authorship 25333318Authorship 135449214Authorship 1355339133988715McCann CD, van Dorp CH, Danesh A, Ward AR, Dilling TR, Mota TM, Zale E, Stevenson EM, Patel S, Brumme CJ, Dong W, Jones DS, Andresen TL, Walker BD, Brumme ZL, Bollard CM, Perelson AS, Irvine DJ, Jones RBThe Journal of experimental medicineA participant-derived xenograft model of HIV enables long-term evaluation of autologous immunotherapies. J Exp Med. 2021 07 05; 218(7).J Exp Med2021-05-14T00:00:002021A participant-derived xenograft model of HIV enables long-term evaluation of autologous immunotherapies.33990380Walker BDScience immunologyCMV, MHC-E, and the quest for an unconventional AIDS vaccine. Sci Immunol. 2021 05 14; 6(59).Sci Immunol2021-05-14T00:00:002021CMV, MHC-E, and the quest for an unconventional AIDS vaccine.Authorship 1358456834025670Singh R, Ramsuran V, Naranbhai V, Yende-Zuma N, Garrett N, Mlisana K, Dong KL, Walker BD, Abdool Karim SS, Carrington M, Ndung'u TFrontiers in immunologyEpigenetic Regulation of BST-2 Expression Levels and the Effect on HIV-1 Pathogenesis. Front Immunol. 2021; 12:669241.Front Immunol2021-05-05T00:00:002021Epigenetic Regulation of BST-2 Expression Levels and the Effect on HIV-1 Pathogenesis.34265281Nathan A, Rossin EJ, Kaseke C, Park RJ, Khatri A, Koundakjian D, Urbach JM, Singh NK, Bashirova A, Tano-Menka R, Senjobe F, Waring MT, Piechocka-Trocha A, Garcia-Beltran WF, Iafrate AJ, Naranbhai V, Carrington M, Walker BD, Gaiha GDCellStructure-guided T cell vaccine design for SARS-CoV-2 variants and sarbecoviruses. Cell. 2021 08 19; 184(17):4401-4413.e10.Cell2021-06-30T00:00:002021Structure-guided T cell vaccine design for SARS-CoV-2 variants and sarbecoviruses.34260940Kaseke C, Park RJ, Singh NK, Koundakjian D, Bashirova A, Garcia Beltran WF, Takou Mbah OC, Ma J, Senjobe F, Urbach JM, Nathan A, Rossin EJ, Tano-Menka R, Khatri A, Piechocka-Trocha A, Waring MT, Birnbaum ME, Baker BM, Carrington M, Walker BD, Gaiha GDCell reportsHLA class-I-peptide stability mediates CD8+ T cell immunodominance hierarchies and facilitates HLA-associated immune control of HIV. Cell Rep. 2021 07 13; 36(2):109378.Cell Rep2021-07-13T00:00:002021HLA class-I-peptide stability mediates CD8+ T cell immunodominance hierarchies and facilitates HLA-associated immune control of HIV.Authorship 137528218Authorship 137580320Authorship 1866687Authorship 1522713Authorship 167411734433692Galván-Peña S, Leon J, Chowdhary K, Michelson DA, Vijaykumar B, Yang L, Magnuson AM, Chen F, Manickas-Hill Z, Piechocka-Trocha A, Worrall DP, Hall KE, Ghebremichael M, Walker BD, Li JZ, Yu XG, Mathis D, Benoist CProceedings of the National Academy of Sciences of the United States of AmericaProfound Treg perturbations correlate with COVID-19 severity. Proc Natl Acad Sci U S A. 2021 09 14; 118(37).Proc Natl Acad Sci U S A2021-09-14T00:00:002021Profound Treg perturbations correlate with COVID-19 severity.Authorship 13882401434496223Collins DR, Urbach JM, Racenet ZJ, Arshad U, Power KA, Newman RM, Mylvaganam GH, Ly NL, Lian X, Rull A, Rassadkina Y, Yanez AG, Peluso MJ, Deeks SG, Vidal F, Lichterfeld M, Yu XG, Gaiha GD, Allen TM, Walker BDImmunityFunctional impairment of HIV-specific CD8+ T cells precedes aborted spontaneous control of viremia. Immunity. 2021 10 12; 54(10):2372-2384.e7.Immunity2021-09-07T00:00:002021Functional impairment of HIV-specific CD8+ T cells precedes aborted spontaneous control of viremia.Authorship 139216020Authorship 1822961Authorship 2057573Authorship 20923118Authorship 140973214Authorship 141100716Authorship 14108961834781719Turk G, Seiger K, Lian X, Sun W, Parsons EM, Gao C, Rassadkina Y, Polo ML, Czernikier A, Ghiglione Y, Vellicce A, Varriale J, Lai J, Yuki Y, Martin M, Rhodes A, Lewin SR, Walker BD, Carrington M, Siliciano R, Siliciano J, Lichterfeld M, Laufer N, Yu XGAnnals of internal medicineA Possible Sterilizing Cure of HIV-1 Infection Without Stem Cell Transplantation. Ann Intern Med. 2022 01; 175(1):95-100.Ann Intern Med2021-11-16T00:00:002021A Possible Sterilizing Cure of HIV-1 Infection Without Stem Cell Transplantation.34781741Omondi FH, Sudderuddin H, Shahid A, Kinloch NN, Jones BR, Miller RL, Tsai O, MacMillan D, Trocha A, Brockman MA, Brumme CJ, Joy JB, Liang R, Walker BD, Brumme ZLmBioHIV Proviral Burden, Genetic Diversity, and Dynamics in Viremic Controllers Who Subsequently Initiated Suppressive Antiretroviral Therapy. mBio. 2021 12 21; 12(6):e0249021.mBio2021-11-16T00:00:002021HIV Proviral Burden, Genetic Diversity, and Dynamics in Viremic Controllers Who Subsequently Initiated Suppressive Antiretroviral Therapy.34793581Vieira VA, Adland E, Malone DFG, Martin MP, Groll A, Ansari MA, Garcia-Guerrero MC, Puertas MC, Muenchhoff M, Guash CF, Brander C, Martinez-Picado J, Bamford A, Tudor-Williams G, Ndung'u T, Walker BD, Ramsuran V, Frater J, Jooste P, Peppa D, Carrington M, Goulder PJRPLoS pathogensAn HLA-I signature favouring KIR-educated Natural Killer cells mediates immune control of HIV in children and contrasts with the HLA-B-restricted CD8+ T-cell-mediated immune control in adults. PLoS Pathog. 2021 11; 17(11):e1010090.PLoS Pathog2021-11-18T00:00:002021An HLA-I signature favouring KIR-educated Natural Killer cells mediates immune control of HIV in children and contrasts with the HLA-B-restricted CD8+ T-cell-mediated immune control in adults.Authorship 14201081634910552Lian X, Gao C, Sun X, Jiang C, Einkauf KB, Seiger KW, Chevalier JM, Yuki Y, Martin M, Hoh R, Peluso MJ, Carrington M, Ruiz-Mateos E, Deeks SG, Rosenberg ES, Walker BD, Lichterfeld M, Yu XGScience translational medicineSignatures of immune selection in intact and defective proviruses distinguish HIV-1 elite controllers. Sci Transl Med. 2021 12 15; 13(624):eabl4097.Sci Transl Med2021-12-15T00:00:002021Signatures of immune selection in intact and defective proviruses distinguish HIV-1 elite controllers.34991160Ogunshola FJ, Smidt W, Naidoo AF, Nkosi T, Ngubane T, Khaba T, Baiyegunhi OO, Mahlobo B, Rasehlo S, Ngema N, Jajbhay I, Dong KL, Ramsuran V, Pansegrouw J, Ndung'u T, Walker BD, Oliveria T, Ndhlovu ZMBlood advancesHypermethylation at the CXCR5 gene locus limits trafficking potential of CD8+ T cells into B-cell follicles during HIV-1 infection. Blood Adv. 2022 03 22; 6(6):1904-1916.Blood Adv2022-03-22T00:00:002022Hypermethylation at the CXCR5 gene locus limits trafficking potential of CD8+ T cells into B-cell follicles during HIV-1 infection.35018386Naranbhai V, Nathan A, Kaseke C, Berrios C, Khatri A, Choi S, Getz MA, Tano-Menka R, Ofoman O, Gayton A, Senjobe F, Denis KJS, Lam EC, Garcia-Beltran WF, Balazs AB, Walker BD, Iafrate AJ, Gaiha GDmedRxiv : the preprint server for health sciencesT cell reactivity to the SARS-CoV-2 Omicron variant is preserved in most but not all prior infected and vaccinated individuals. medRxiv. 2022 Jan 05.medRxiv2022-01-05T00:00:002022T cell reactivity to the SARS-CoV-2 Omicron variant is preserved in most but not all prior infected and vaccinated individuals.Authorship 142601516true1Professor of MedicineProfessor of MedicineAuthorship 143645918Authorship 143671815Authorship 144025918Authorship 143608714Authorship 143901616Authorship 143924113Authorship 1440315435275061Silverstein NJ, Wang Y, Manickas-Hill Z, Carbone C, Dauphin A, Boribong BP, Loiselle M, Davis J, Leonard MM, Kuri-Cervantes L, Meyer NJ, Betts MR, Li JZ, Walker BD, Yu XG, Yonker LM, Luban JeLifeInnate lymphoid cells and COVID-19 severity in SARS-CoV-2 infection. Elife. 2022 03 11; 11.Elife2022-03-11T00:00:002022Innate lymphoid cells and COVID-19 severity in SARS-CoV-2 infection.35159122Zhang A, Piechocka-Trocha A, Li X, Walker BDCellsA Leucine Zipper Dimerization Strategy to Generate Soluble T Cell Receptors Using the Escherichia coli Expression System. Cells. 2022 01 18; 11(3).Cells2022-01-18T00:00:002022A Leucine Zipper Dimerization Strategy to Generate Soluble T Cell Receptors Using the Escherichia coli Expression System.35230385Lorin V, Fernández I, Masse-Ranson G, Bouvin-Pley M, Molinos-Albert LM, Planchais C, Hieu T, Péhau-Arnaudet G, Hrebík D, Girelli-Zubani G, Fiquet O, Guivel-Benhassine F, Sanders RW, Walker BD, Schwartz O, Scheid JF, Dimitrov JD, Plevka P, Braibant M, Seaman MS, Bontems F, Di Santo JP, Rey FA, Mouquet HThe Journal of experimental medicineEpitope convergence of broadly HIV-1 neutralizing IgA and IgG antibody lineages in a viremic controller. J Exp Med. 2022 03 07; 219(3).J Exp Med2022-03-01T00:00:002022Epitope convergence of broadly HIV-1 neutralizing IgA and IgG antibody lineages in a viremic controller.35364034Naranbhai V, Nathan A, Kaseke C, Berrios C, Khatri A, Choi S, Getz MA, Tano-Menka R, Ofoman O, Gayton A, Senjobe F, Zhao Z, St Denis KJ, Lam EC, Carrington M, Garcia-Beltran WF, Balazs AB, Walker BD, Iafrate AJ, Gaiha GDCellT cell reactivity to the SARS-CoV-2 Omicron variant is preserved in most but not all individuals. Cell. 2022 Mar 31; 185(7):1259.Cell2022-03-31T00:00:002022T cell reactivity to the SARS-CoV-2 Omicron variant is preserved in most but not all individuals.35364330Kaneko N, Boucau J, Kuo HH, Perugino C, Mahajan VS, Farmer JR, Liu H, Diefenbach TJ, Piechocka-Trocha A, Lefteri K, Waring MT, Premo KR, Walker BD, Li JZ, Gaiha G, Yu XG, Lichterfeld M, Padera RF, Pillai SClinical immunology (Orlando, Fla.)Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19. Clin Immunol. 2022 04; 237:108991.Clin Immunol2022-03-29T00:00:002022Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19.35202566Naranbhai V, Nathan A, Kaseke C, Berrios C, Khatri A, Choi S, Getz MA, Tano-Menka R, Ofoman O, Gayton A, Senjobe F, Zhao Z, St Denis KJ, Lam EC, Carrington M, Garcia-Beltran WF, Balazs AB, Walker BD, Iafrate AJ, Gaiha GDCellT cell reactivity to the SARS-CoV-2 Omicron variant is preserved in most but not all individuals. Cell. 2022 03 17; 185(6):1041-1051.e6.Cell2022-02-03T00:00:002022T cell reactivity to the SARS-CoV-2 Omicron variant is preserved in most but not all individuals.Authorship 14460911935418681Gaebler C, Nogueira L, Stoffel E, Oliveira TY, Breton G, Millard KG, Turroja M, Butler A, Ramos V, Seaman MS, Reeves JD, Petroupoulos CJ, Shimeliovich I, Gazumyan A, Jiang CS, Jilg N, Scheid JF, Gandhi R, Walker BD, Sneller MC, Fauci A, Chun TW, Caskey M, Nussenzweig MCNatureProlonged viral suppression with anti-HIV-1 antibody therapy. Nature. 2022 06; 606(7913):368-374.Nature2022-04-13T00:00:002022Prolonged viral suppression with anti-HIV-1 antibody therapy.Authorship 3022432Authorship 31924518Authorship 3263282Authorship 36793516Authorship 14588231335831418Baiyegunhi OO, Mann J, Khaba T, Nkosi T, Mbatha A, Ogunshola F, Chasara C, Ismail N, Ngubane T, Jajbhay I, Pansegrouw J, Dong KL, Walker BD, Ndung'u T, Ndhlovu ZMNature communicationsCD8 lymphocytes mitigate HIV-1 persistence in lymph node follicular helper T cells during hyperacute-treated infection. Nat Commun. 2022 07 12; 13(1):4041.Nat Commun2022-07-12T00:00:002022CD8 lymphocytes mitigate HIV-1 persistence in lymph node follicular helper T cells during hyperacute-treated infection.Authorship 1663247Authorship 3999964Authorship 421707Authorship 4221029Authorship 14811951435960796Barnes CO, Schoofs T, Gnanapragasam PNP, Golijanin J, Huey-Tubman KE, Gruell H, Schommers P, Suh-Toma N, Lee YE, Cetrulo Lorenzi JC, Piechocka-Trocha A, Scheid JF, West AP, Walker BD, Seaman MS, Klein F, Nussenzweig MC, Bjorkman PJScience advancesA naturally arising broad and potent CD4-binding site antibody with low somatic mutation. Sci Adv. 2022 Aug 12; 8(32):eabp8155.Sci Adv2022-08-12T00:00:002022A naturally arising broad and potent CD4-binding site antibody with low somatic mutation.Authorship 44567416Authorship 1507577936453881Mandizvo T, Gumede N, Ndlovu B, Ndlovu S, Mann JK, Chopera DR, Singh L, Dong KL, Walker BD, Ndhlovu ZM, Lavine CL, Seaman MS, Gounder K, Ndung'u TJournal of virologySubtle Longitudinal Alterations in Env Sequence Potentiate Differences in Sensitivity to Broadly Neutralizing Antibodies following Acute HIV-1 Subtype C Infection. J Virol. 2022 Dec 01; e0127022.J Virol2022-12-01T00:00:002022Subtle Longitudinal Alterations in Env Sequence Potentiate Differences in Sensitivity to Broadly Neutralizing Antibodies following Acute HIV-1 Subtype C Infection.Authorship 151460111Authorship 15147172136599977Sun W, Gao C, Hartana CA, Osborn MR, Einkauf KB, Lian X, Bone B, Bonheur N, Chun TW, Rosenberg ES, Walker BD, Yu XG, Lichterfeld MNaturePhenotypic signatures of immune selection in HIV-1 reservoir cells. Nature. 2023 02; 614(7947):309-317.Nature2023-01-04T00:00:002023Phenotypic signatures of immune selection in HIV-1 reservoir cells.36602861Vieira V, Lim N, Singh A, Leitman E, Dsouza R, Adland E, Muenchhoff M, Roider J, Marin Lopez M, Carabelli J, Giandhari J, Groll A, Jooste P, Prado JG, Thobakgale C, Dong K, Kiepiela P, Prendergast AJ, Tudor-Williams G, Frater J, Walker BD, Ndung'u T, Ramsuran V, Leslie A, Kløverpris HN, Goulder PJCI insightSlow progression of pediatric HIV associates with early CD8+ T cell PD-1 expression and a stem-like phenotype. JCI Insight. 2023 02 08; 8(3).JCI Insight2023-02-08T00:00:002023Slow progression of pediatric HIV associates with early CD8+ T cell PD-1 expression and a stem-like phenotype.Authorship 20807615Authorship 2205967Authorship 22449833Authorship 23313815Authorship 17099820Authorship 17193111Authorship 18073616Authorship 18591517Authorship 1935772Authorship 47436Authorship 4763796Authorship 4880852037300833Allard-Chamard H, Kaneko N, Bertocchi A, Sun N, Boucau J, Kuo HH, Farmer JR, Perugino C, Mahajan VS, Murphy SJH, Premo K, Diefenbach T, Ghebremichael M, Yuen G, Kotta A, Akman Z, Lichterfeld M, Walker BD, Yu XG, Moriyama M, Maehara T, Nakamura S, Stone JH, Padera RF, Pillai SCell reportsExtrafollicular IgD-CD27-CXCR5-CD11c- DN3 B cells infiltrate inflamed tissues in autoimmune fibrosis and in severe COVID-19. Cell Rep. 2023 06 27; 42(6):112630.Cell Rep2023-05-30T00:00:002023Extrafollicular IgD-CD27-CXCR5-CD11c- DN3 B cells infiltrate inflamed tissues in autoimmune fibrosis and in severe COVID-19.Authorship 50803111Authorship 2583987Ragon Institute of MGH, MIT and HarvardAuthorship 156989910Authorship 156633920Authorship 15555751837217466Li X, Singh NK, Collins DR, Ng R, Zhang A, Lamothe-Molina PA, Shahinian P, Xu S, Tan K, Piechocka-Trocha A, Urbach JM, Weber JK, Gaiha GD, Takou Mbah OC, Huynh T, Cheever S, Chen J, Birnbaum M, Zhou R, Walker BD, Wang JHNature communicationsMolecular basis of differential HLA class I-restricted T cell recognition of a highly networked HIV peptide. Nat Commun. 2023 05 22; 14(1):2929.Nat Commun2023-05-22T00:00:002023Molecular basis of differential HLA class I-restricted T cell recognition of a highly networked HIV peptide.37205767Collins DR, Hitschfel J, Urbach JM, Mylvaganam GH, Ly NL, Arshad U, Racenet ZJ, Yanez AG, Diefenbach TJ, Walker BDScience immunologyCytolytic CD8+ T cells infiltrate germinal centers to limit ongoing HIV replication in spontaneous controller lymph nodes. Sci Immunol. 2023 05 19; 8(83):eade5872.Sci Immunol2023-05-19T00:00:002023Cytolytic CD8+ T cells infiltrate germinal centers to limit ongoing HIV replication in spontaneous controller lymph nodes.Authorship 28036318Authorship 29065417Authorship 22716114Authorship 3320226Authorship 34801410Authorship 34871325Authorship 35359914Authorship 159166059Authorship 15925465937532928McLaren PJ, Porreca I, Iaconis G, Mok HP, Mukhopadhyay S, Karakoc E, Cristinelli S, Pomilla C, Bartha I, Thorball CW, Tough RH, Angelino P, Kiar CS, Carstensen T, Fatumo S, Porter T, Jarvis I, Skarnes WC, Bassett A, DeGorter MK, Sathya Moorthy MP, Tuff JF, Kim EY, Walter M, Simons LM, Bashirova A, Buchbinder S, Carrington M, Cossarizza A, De Luca A, Goedert JJ, Goldstein DB, Haas DW, Herbeck JT, Johnson EO, Kaleebu P, Kilembe W, Kirk GD, Kootstra NA, Kral AH, Lambotte O, Luo M, Mallal S, Martinez-Picado J, Meyer L, Miro JM, Moodley P, Motala AA, Mullins JI, Nam K, Obel N, Pirie F, Plummer FA, Poli G, Price MA, Rauch A, Theodorou I, Trkola A, Walker BD, Winkler CA, Zagury JF, Montgomery SB, Ciuffi A, Hultquist JF, Wolinsky SM, Dougan G, Lever AML, Gurdasani D, Groom H, Sandhu MS, Fellay JNatureAfrica-specific human genetic variation near CHD1L associates with HIV-1 load. Nature. 2023 Aug; 620(7976):1025-1030.Nature2023-08-02T00:00:002023Africa-specific human genetic variation near CHD1L associates with HIV-1 load.37670157McLaren PJ, Porreca I, Iaconis G, Mok HP, Mukhopadhyay S, Karakoc E, Cristinelli S, Pomilla C, Bartha I, Thorball CW, Tough RH, Angelino P, Kiar CS, Carstensen T, Fatumo S, Porter T, Jarvis I, Skarnes WC, Bassett A, DeGorter MK, Sathya Moorthy MP, Tuff JF, Kim EY, Walter M, Simons LM, Bashirova A, Buchbinder S, Carrington M, Cossarizza A, De Luca A, Goedert JJ, Goldstein DB, Haas DW, Herbeck JT, Johnson EO, Kaleebu P, Kilembe W, Kirk GD, Kootstra NA, Kral AH, Lambotte O, Luo M, Mallal S, Martinez-Picado J, Meyer L, Miro JM, Moodley P, Motala AA, Mullins JI, Nam K, Obel N, Pirie F, Plummer FA, Poli G, Price MA, Rauch A, Theodorou I, Trkola A, Walker BD, Winkler CA, Zagury JF, Montgomery SB, Ciuffi A, Hultquist JF, Wolinsky SM, Dougan G, Lever AML, Gurdasani D, Groom H, Sandhu MS, Fellay JNatureAuthor Correction: Africa-specific human genetic variation near CHD1L associates with HIV-1 load. Nature. 2023 Sep; 621(7979):E42.Nature2023-09-01T00:00:002023Author Correction: Africa-specific human genetic variation near CHD1L associates with HIV-1 load.2Professor of ImmunologyProfessor of Immunologytrue1William Bosworth Castle Professor of MedicineWilliam Bosworth Castle Professor of Medicinetrue1Phillip T. and Susan M. Ragon Professor of MedicinePhillip T. and Susan M. Ragon Professor of MedicineAuthorship 4260039true1Member of the Faculty of MedicineMember of the Faculty of MedicineAuthorship 4423403Authorship 4519152Authorship 462183838019932Zonozi R, Walters LC, Shulkin A, Naranbhai V, Nithagon P, Sauvage G, Kaeske C, Cosgrove K, Nathan A, Tano-Menka R, Gayton AC, Getz MA, Senjobe F, Worrall D, Iafrate AJ, Fromson C, Montesi SB, Rao DA, Sparks JA, Wallace ZS, Farmer JR, Walker BD, Charles RC, Laliberte K, Niles JL, Gaiha GDScience translational medicineT cell responses to SARS-CoV-2 infection and vaccination are elevated in B cell deficiency and reduce risk of severe COVID-19. Sci Transl Med. 2023 11 29; 15(724):eadh4529.Sci Transl Med2023-11-29T00:00:002023T cell responses to SARS-CoV-2 infection and vaccination are elevated in B cell deficiency and reduce risk of severe COVID-19.Authorship 161157322Authorship 5107669Authorship 5108305Authorship 16217611438236978Viard M, O'hUigin C, Yuki Y, Bashirova AA, Collins DR, Urbach JM, Wolinsky S, Buchbinder S, Kirk GD, Goedert JJ, Michael NL, Haas DW, Deeks SG, Walker BD, Yu X, Carrington MScience (New York, N.Y.)Impact of HLA class I functional divergence on HIV control. Science. 2024 01 19; 383(6680):319-325.Science2024-01-18T00:00:002024Impact of HLA class I functional divergence on HIV control.true1Professor of MedicineProfessor of MedicineAuthorship 5187508Authorship 5370605Authorship 5425536true1Professor of MedicineProfessor of Medicinetrue1Professor of Medicine (on leave)Professor of Medicine (on leave)Authorship 54613426Authorship 5686578Authorship 616885Authorship 1633359Authorship 16985812Authorship 2459549Authorship 33287113Authorship 34421411Authorship 37611326Authorship 38762013Authorship 3889424Authorship 2419768Authorship 2371881Authorship 42575821Authorship 4317257Authorship 4444307Authorship 4550393Authorship 23981922Authorship 2808408Authorship 2905388Authorship 3301424Authorship 490827Authorship 6684732Authorship 65040114Authorship 6581667Authorship 66817138Authorship 6487244Authorship 6480223Authorship 65030213Authorship 651148123797064Walker BD, Yu XGNature reviews. ImmunologyUnravelling the mechanisms of durable control of HIV-1. Nat Rev Immunol. 2013 Jul; 13(7):487-98.Nat Rev Immunol2013-07-01T00:00:002013Unravelling the mechanisms of durable control of HIV-1.23723240Koff WC, Burton DR, Johnson PR, Walker BD, King CR, Nabel GJ, Ahmed R, Bhan MK, Plotkin SAScience (New York, N.Y.)Accelerating next-generation vaccine development for global disease prevention. Science. 2013 May 31; 340(6136):1232910.Science2013-05-31T00:00:002013Accelerating next-generation vaccine development for global disease prevention.22404163Lee W, Kuchar DL, Walker BD, Subbiah RNPacing and clinical electrophysiology : PACEIsolated ventricular noncompaction: implications for mechanisms of sudden cardiac death. Pacing Clin Electrophysiol. 2013 May; 36(5):e153-5.Pacing Clin Electrophysiol2012-03-08T00:00:002012Isolated ventricular noncompaction: implications for mechanisms of sudden cardiac death.23935489McLaren PJ, Coulonges C, Ripke S, van den Berg L, Buchbinder S, Carrington M, Cossarizza A, Dalmau J, Deeks SG, Delaneau O, De Luca A, Goedert JJ, Haas D, Herbeck JT, Kathiresan S, Kirk GD, Lambotte O, Luo M, Mallal S, van Manen D, Martinez-Picado J, Meyer L, Miro JM, Mullins JI, Obel N, O'Brien SJ, Pereyra F, Plummer FA, Poli G, Qi Y, Rucart P, Sandhu MS, Shea PR, Schuitemaker H, Theodorou I, Vannberg F, Veldink J, Walker BD, Weintrob A, Winkler CA, Wolinsky S, Telenti A, Goldstein DB, de Bakker PI, Zagury JF, Fellay JPLoS pathogensAssociation study of common genetic variants and HIV-1 acquisition in 6,300 infected cases and 7,200 controls. PLoS Pathog. 2013; 9(7):e1003515.PLoS Pathog2013-07-25T00:00:002013Association study of common genetic variants and HIV-1 acquisition in 6,300 infected cases and 7,200 controls.23793098Ranasinghe S, Cutler S, Davis I, Lu R, Soghoian DZ, Qi Y, Sidney J, Kranias G, Flanders MD, Lindqvist M, Kuhl B, Alter G, Deeks SG, Walker BD, Gao X, Sette A, Carrington M, Streeck HNature medicineAssociation of HLA-DRB1-restricted CD4? T cell responses with HIV immune control. Nat Med. 2013 Jul; 19(7):930-3.Nat Med2013-06-23T00:00:002013Association of HLA-DRB1-restricted CD4? T cell responses with HIV immune control.23805139Shasha D, Walker BDFrontiers in immunologyLessons to be Learned from Natural Control of HIV - Future Directions, Therapeutic, and Preventive Implications. Front Immunol. 2013; 4:162.Front Immunol2013-06-25T00:00:002013Lessons to be Learned from Natural Control of HIV - Future Directions, Therapeutic, and Preventive Implications.23772031Youngblood B, Noto A, Porichis F, Akondy RS, Ndhlovu ZM, Austin JW, Bordi R, Procopio FA, Miura T, Allen TM, Sidney J, Sette A, Walker BD, Ahmed R, Boss JM, Sékaly RP, Kaufmann DEJournal of immunology (Baltimore, Md. : 1950)Cutting edge: Prolonged exposure to HIV reinforces a poised epigenetic program for PD-1 expression in virus-specific CD8 T cells. J Immunol. 2013 Jul 15; 191(2):540-4.J Immunol2013-06-14T00:00:002013Cutting edge: Prolonged exposure to HIV reinforces a poised epigenetic program for PD-1 expression in virus-specific CD8 T cells.23598483Koff WC, Russell ND, Walport M, Feinberg MB, Shiver JW, Karim SA, Walker BD, McGlynn MG, Nweneka CV, Nabel GJVaccineAccelerating the development of a safe and effective HIV vaccine: HIV vaccine case study for the Decade of Vaccines. Vaccine. 2013 Apr 18; 31 Suppl 2:B204-8.Vaccine2013-04-18T00:00:002013Accelerating the development of a safe and effective HIV vaccine: HIV vaccine case study for the Decade of Vaccines.Authorship 3682542Authorship 37202325Authorship 3729666Authorship 8935514Authorship 3759129Authorship 621336Authorship 676485Authorship 7167215Authorship 1972992Authorship 19882014Authorship 76491ImmunologyAuthorship 670494923525031Kløverpris HN, Stryhn A, Harndahl M, Carlson JM, Leslie AJ, Chen F, Riddell L, Mulenga J, Walker BD, Ndung'u T, Buus S, Goulder PAIDS (London, England)HLA-A*68:02-restricted Gag-specific cytotoxic T lymphocyte responses can drive selection pressure on HIV but are subdominant and ineffective. AIDS. 2013 Jul 17; 27(11):1717-23.AIDS2013-07-17T00:00:002013HLA-A*68:02-restricted Gag-specific cytotoxic T lymphocyte responses can drive selection pressure on HIV but are subdominant and ineffective.Authorship 55201821Authorship 55839018Authorship 917964Authorship 928902424041011Mann JK, Byakwaga H, Kuang XT, Le AQ, Brumme CJ, Mwimanzi P, Omarjee S, Martin E, Lee GQ, Baraki B, Danroth R, McCloskey R, Muzoora C, Bangsberg DR, Hunt PW, Goulder PJ, Walker BD, Harrigan PR, Martin JN, Ndung'u T, Brockman MA, Brumme ZLRetrovirologyAbility of HIV-1 Nef to downregulate CD4 and HLA class I differs among viral subtypes. Retrovirology. 2013 Sep 16; 10:100.Retrovirology2013-09-16T00:00:002013Ability of HIV-1 Nef to downregulate CD4 and HLA class I differs among viral subtypes.Authorship 2212197Authorship 6753542Authorship 6753078Authorship 6785632Authorship 6772271523790534Pellegrini M, Walker BDCurrent opinion in immunologyHost pathogen interactions at the coalface of immunity. Curr Opin Immunol. 2013 Aug; 25(4):425-7.Curr Opin Immunol2013-06-19T00:00:002013Host pathogen interactions at the coalface of immunity.24022159Ranasinghe S, Walker BDNature biotechnologyProgramming CMV for vaccine vector design. Nat Biotechnol. 2013 Sep; 31(9):811-2.Nat Biotechnol2013-09-01T00:00:002013Programming CMV for vaccine vector design.24023819Adland E, Carlson JM, Paioni P, Kløverpris H, Shapiro R, Ogwu A, Riddell L, Luzzi G, Chen F, Balachandran T, Heckerman D, Stryhn A, Edwards A, Ndung'u T, Walker BD, Buus S, Goulder P, Matthews PCPloS oneNef-specific CD8+ T cell responses contribute to HIV-1 immune control. PLoS One. 2013; 8(9):e73117.PLoS One2013-09-02T00:00:002013Nef-specific CD8+ T cell responses contribute to HIV-1 immune control.23864640Kløverpris HN, Stryhn A, Harndahl M, Payne R, Towers GJ, Chen F, Riddell L, Walker BD, Ndung'u T, Leslie A, Buus S, Goulder PJournal of virologyHLA-specific intracellular epitope processing shapes an immunodominance pattern for HLA-B*57 that is distinct from HLA-B*58:01. J Virol. 2013 Oct; 87(19):10889-94.J Virol2013-07-17T00:00:002013HLA-specific intracellular epitope processing shapes an immunodominance pattern for HLA-B*57 that is distinct from HLA-B*58:01.Authorship 6797741024124451Kløverpris HN, Jackson A, Handley A, Hayes P, Gilmour J, Riddell L, Chen F, Atkins M, Boffito M, Walker BD, Ackland J, Sullivan M, Goulder PPloS oneNon-immunogenicity of overlapping gag peptides pulsed on autologous cells after vaccination of HIV infected individuals. PLoS One. 2013; 8(10):e74389.PLoS One2013-10-04T00:00:002013Non-immunogenicity of overlapping gag peptides pulsed on autologous cells after vaccination of HIV infected individuals.Authorship 684661123002014Walker B, McMichael ACold Spring Harbor perspectives in medicineThe T-cell response to HIV. Cold Spring Harb Perspect Med. 2012 Nov 01; 2(11).Cold Spring Harb Perspect Med2012-11-01T00:00:002012The T-cell response to HIV.Authorship 32410711Authorship 3298728Authorship 3540581Authorship 17869729Authorship 3810451Authorship 1804803Authorship 6990262024248364Kulkarni S, Qi Y, O'hUigin C, Pereyra F, Ramsuran V, McLaren P, Fellay J, Nelson G, Chen H, Liao W, Bass S, Apps R, Gao X, Yuki Y, Lied A, Ganesan A, Hunt PW, Deeks SG, Wolinsky S, Walker BD, Carrington MProceedings of the National Academy of Sciences of the United States of AmericaGenetic interplay between HLA-C and MIR148A in HIV control and Crohn disease. Proc Natl Acad Sci U S A. 2013 Dec 17; 110(51):20705-10.Proc Natl Acad Sci U S A2013-11-18T00:00:002013Genetic interplay between HLA-C and MIR148A in HIV control and Crohn disease.Authorship 70044217Authorship 702116924391773Wong EB, Akilimali NA, Govender P, Sullivan ZA, Cosgrove C, Pillay M, Lewinsohn DM, Bishai WR, Walker BD, Ndung'u T, Klenerman P, Kasprowicz VOPloS oneLow levels of peripheral CD161++CD8+ mucosal associated invariant T (MAIT) cells are found in HIV and HIV/TB co-infection. PLoS One. 2013; 8(12):e83474.PLoS One2013-12-31T00:00:002013Low levels of peripheral CD161++CD8+ mucosal associated invariant T (MAIT) cells are found in HIV and HIV/TB co-infection.Authorship 25291917Authorship 2602635Authorship 7049761524245727Vaidya SA, Streeck H, Beckwith N, Ghebremichael M, Pereyra F, Kwon DS, Addo MM, Rychert J, Routy JP, Jessen H, Kelleher AD, Hecht F, Sekaly RP, Carrington M, Walker BD, Allen TM, Rosenberg ES, Altfeld MRetrovirologyTemporal effect of HLA-B*57 on viral control during primary HIV-1 infection. Retrovirology. 2013 Nov 18; 10:139.Retrovirology2013-11-18T00:00:002013Temporal effect of HLA-B*57 on viral control during primary HIV-1 infection.Authorship 26907816Authorship 2936115Authorship 3048922Authorship 4150287Authorship 416308Authorship 6583112Authorship 666611224664171Angin M, Sharma S, King M, Murooka TT, Ghebremichael M, Mempel TR, Walker BD, Bhasin MK, Addo MMThe Journal of infectious diseasesHIV-1 infection impairs regulatory T-cell suppressive capacity on a per-cell basis. J Infect Dis. 2014 Sep 15; 210(6):899-903.J Infect Dis2014-03-23T00:00:002014HIV-1 infection impairs regulatory T-cell suppressive capacity on a per-cell basis.Authorship 2094753Authorship 2956697Authorship 47216914Authorship 20367515Authorship 2047478Authorship 71831225Authorship 7250927Authorship 7252072Authorship 72307013Authorship 719846724597871Kay MA, Walker BDThe New England journal of medicineEngineering cellular resistance to HIV. N Engl J Med. 2014 Mar 06; 370(10):968-9.N Engl J Med2014-03-06T00:00:002014Engineering cellular resistance to HIV.24522437Xia Z, Chen H, Kang SG, Huynh T, Fang JW, Lamothe PA, Walker BD, Zhou RScientific reportsThe complex and specific pMHC interactions with diverse HIV-1 TCR clonotypes reveal a structural basis for alterations in CTL function. Sci Rep. 2014 Feb 13; 4:4087.Sci Rep2014-02-13T00:00:002014The complex and specific pMHC interactions with diverse HIV-1 TCR clonotypes reveal a structural basis for alterations in CTL function.24412925Buzon MJ, Sun H, Li C, Shaw A, Seiss K, Ouyang Z, Martin-Gayo E, Leng J, Henrich TJ, Li JZ, Pereyra F, Zurakowski R, Walker BD, Rosenberg ES, Yu XG, Lichterfeld MNature medicineHIV-1 persistence in CD4+ T cells with stem cell-like properties. Nat Med. 2014 Feb; 20(2):139-42.Nat Med2014-01-12T00:00:002014HIV-1 persistence in CD4+ T cells with stem cell-like properties.24551068Foley MH, Forcier T, McAndrew E, Gonzalez M, Chen H, Juelg B, Walker BD, Irvine DJPloS oneHigh avidity CD8+ T cells efficiently eliminate motile HIV-infected targets and execute a locally focused program of anti-viral function. PLoS One. 2014; 9(2):e87873.PLoS One2014-02-13T00:00:002014High avidity CD8+ T cells efficiently eliminate motile HIV-infected targets and execute a locally focused program of anti-viral function.24603468Bashirova AA, Martin-Gayo E, Jones DC, Qi Y, Apps R, Gao X, Burke PS, Taylor CJ, Rogich J, Wolinsky S, Bream JH, Duggal P, Hussain S, Martinson J, Weintrob A, Kirk GD, Fellay J, Buchbinder SP, Goedert JJ, Deeks SG, Pereyra F, Trowsdale J, Lichterfeld M, Telenti A, Walker BD, Allen RL, Carrington M, Yu XGPLoS geneticsLILRB2 interaction with HLA class I correlates with control of HIV-1 infection. PLoS Genet. 2014 Mar; 10(3):e1004196.PLoS Genet2014-03-06T00:00:002014LILRB2 interaction with HLA class I correlates with control of HIV-1 infection.Authorship 21443919Authorship 25496414Authorship 25720516Authorship 2603258Authorship 72665220Authorship 7276748Authorship 726575724762668Cotton LA, Kuang XT, Le AQ, Carlson JM, Chan B, Chopera DR, Brumme CJ, Markle TJ, Martin E, Shahid A, Anmole G, Mwimanzi P, Nassab P, Penney KA, Rahman MA, Milloy MJ, Schechter MT, Markowitz M, Carrington M, Walker BD, Wagner T, Buchbinder S, Fuchs J, Koblin B, Mayer KH, Harrigan PR, Brockman MA, Poon AF, Brumme ZLPLoS geneticsGenotypic and functional impact of HIV-1 adaptation to its host population during the North American epidemic. PLoS Genet. 2014 Apr; 10(4):e1004295.PLoS Genet2014-04-24T00:00:002014Genotypic and functional impact of HIV-1 adaptation to its host population during the North American epidemic.24010680Kløverpris HN, Adland E, Koyanagi M, Stryhn A, Harndahl M, Matthews PC, Shapiro R, Walker BD, Ndung'u T, Brander C, Takiguchi M, Buus S, Goulder PAIDS research and human retrovirusesHIV subtype influences HLA-B*07:02-associated HIV disease outcome. AIDS Res Hum Retroviruses. 2014 May; 30(5):468-75.AIDS Res Hum Retroviruses2013-10-04T00:00:002013HIV subtype influences HLA-B*07:02-associated HIV disease outcome.24602776Ogunniyi AO, Thomas BA, Politano TJ, Varadarajan N, Landais E, Poignard P, Walker BD, Kwon DS, Love JCVaccineProfiling human antibody responses by integrated single-cell analysis. Vaccine. 2014 May 19; 32(24):2866-73.Vaccine2014-03-03T00:00:002014Profiling human antibody responses by integrated single-cell analysis.Authorship 2197178Authorship 22025212Authorship 3061952Authorship 1818291Authorship 2456854Authorship 736425524922574Leng J, Ho HP, Buzon MJ, Pereyra F, Walker BD, Yu XG, Chang EJ, Lichterfeld MCell host & microbeA cell-intrinsic inhibitor of HIV-1 reverse transcription in CD4(+) T cells from elite controllers. Cell Host Microbe. 2014 Jun 11; 15(6):717-728.Cell Host Microbe2014-06-11T00:00:002014A cell-intrinsic inhibitor of HIV-1 reverse transcription in CD4(+) T cells from elite controllers.Authorship 1667097Authorship 31660518Authorship 16944413Authorship 296055Authorship 3613192Authorship 3888551Authorship 39920120Authorship 33600013Authorship 2846618Authorship 34355620Authorship 36113115Authorship 3864698Authorship 39157218Authorship 4765328Authorship 7472885Authorship 74966820Authorship 7483697Authorship 74949315Authorship 7476971225102049Mann JK, Barton JP, Ferguson AL, Omarjee S, Walker BD, Chakraborty A, Ndung'u TPLoS computational biologyThe fitness landscape of HIV-1 gag: advanced modeling approaches and validation of model predictions by in vitro testing. PLoS Comput Biol. 2014 Aug; 10(8):e1003776.PLoS Comput Biol2014-08-07T00:00:002014The fitness landscape of HIV-1 gag: advanced modeling approaches and validation of model predictions by in vitro testing.24965451Buzon MJ, Martin-Gayo E, Pereyra F, Ouyang Z, Sun H, Li JZ, Piovoso M, Shaw A, Dalmau J, Zangger N, Martinez-Picado J, Zurakowski R, Yu XG, Telenti A, Walker BD, Rosenberg ES, Lichterfeld MJournal of virologyLong-term antiretroviral treatment initiated at primary HIV-1 infection affects the size, composition, and decay kinetics of the reservoir of HIV-1-infected CD4 T cells. J Virol. 2014 Sep 01; 88(17):10056-65.J Virol2014-06-25T00:00:002014Long-term antiretroviral treatment initiated at primary HIV-1 infection affects the size, composition, and decay kinetics of the reservoir of HIV-1-infected CD4 T cells.25122219Jones RB, O'Connor R, Mueller S, Foley M, Szeto GL, Karel D, Lichterfeld M, Kovacs C, Ostrowski MA, Trocha A, Irvine DJ, Walker BDPLoS pathogensHistone deacetylase inhibitors impair the elimination of HIV-infected cells by cytotoxic T-lymphocytes. PLoS Pathog. 2014 Aug; 10(8):e1004287.PLoS Pathog2014-08-14T00:00:002014Histone deacetylase inhibitors impair the elimination of HIV-infected cells by cytotoxic T-lymphocytes.24965469Kuang XT, Li X, Anmole G, Mwimanzi P, Shahid A, Le AQ, Chong L, Qian H, Miura T, Markle T, Baraki B, Connick E, Daar ES, Jessen H, Kelleher AD, Little S, Markowitz M, Pereyra F, Rosenberg ES, Walker BD, Ueno T, Brumme ZL, Brockman MAJournal of virologyImpaired Nef function is associated with early control of HIV-1 viremia. J Virol. 2014 Sep 01; 88(17):10200-13.J Virol2014-06-25T00:00:002014Impaired Nef function is associated with early control of HIV-1 viremia.Authorship 54041813Authorship 547311725211438Chetty S, Porichis F, Govender P, Zupkosky J, Ghebremichael M, Pillay M, Walker BD, Ndung'u T, Kaufmann DE, Kasprowicz VOAIDS (London, England)Tuberculosis distorts the inhibitory impact of interleukin-10 in HIV infection. AIDS. 2014 Nov 28; 28(18):2671-6.AIDS2014-11-28T00:00:002014Tuberculosis distorts the inhibitory impact of interleukin-10 in HIV infection.Authorship 41121610Authorship 4294621Authorship 619124Authorship 76635411Authorship 7663074Authorship 7663206Authorship 76510414Authorship 7662876Authorship 7663017Authorship 7662729Authorship 7663309Authorship 766353825357936Ranasinghe S, Davis I, Soghoian D, Lamothe P, Sidney J, Sette A, Carrington M, Streeck H, Picker L, Kaufmann D, Walker BAIDS research and human retrovirusesParadigm-violating HLA Class II-restricted CD8 T-cells in HIV-infection. AIDS Res Hum Retroviruses. 2014 Oct; 30 Suppl 1:A75.AIDS Res Hum Retroviruses2014-10-01T00:00:002014Paradigm-violating HLA Class II-restricted CD8 T-cells in HIV-infection.25357934Martin-Gayo E, Hickman T, Ouyang Z, Cubas R, Lindqvist M, Kauffman D, Haddad E, Walker B, Lichterfeld M, Yu XGAIDS research and human retrovirusesDendritic Cells from HIV-1 Neutralizers Efficiently Induce the Generation of CXCR5(+) CXCR3(+) PD1(Lo) CD4 T Cells with B Cell Helper Function. AIDS Res Hum Retroviruses. 2014 Oct; 30 Suppl 1:A74.AIDS Res Hum Retroviruses2014-10-01T00:00:002014Dendritic Cells from HIV-1 Neutralizers Efficiently Induce the Generation of CXCR5(+) CXCR3(+) PD1(Lo) CD4 T Cells with B Cell Helper Function.25357496Laher F, Ranasinghe S, Porichis F, Davis I, Mavrothalassitis O, Ismail N, Mewalal N, Mahungela S, Walker BD, Ndung'u T, Ndhlovu ZMAIDS research and human retrovirusesDifferences in Immunodominant Patterns and HLA-DRB1 Restriction Characteristics in HIV-specific CD4 T-cell Responses between Clade B and C Infection. AIDS Res Hum Retroviruses. 2014 Oct; 30 Suppl 1:A177.AIDS Res Hum Retroviruses2014-10-01T00:00:002014Differences in Immunodominant Patterns and HLA-DRB1 Restriction Characteristics in HIV-specific CD4 T-cell Responses between Clade B and C Infection.25357647Doherty KE, Anahtar M, Ghebremichael M, Thogabekale C, Padavattan N, Dong K, Walker BD, Ndung'u T, Kwon DSAIDS research and human retrovirusesEffects of Intra-vaginal Drying Agents on Mucosal Immune Activation and Risk for HIV Acquisition in South African Women. AIDS Res Hum Retroviruses. 2014 Oct; 30 Suppl 1:A230-1.AIDS Res Hum Retroviruses2014-10-01T00:00:002014Effects of Intra-vaginal Drying Agents on Mucosal Immune Activation and Risk for HIV Acquisition in South African Women.25357698Ndlovu BG, Chung A, Maroa J, Walker BD, Alter G, Ndung'u TAIDS research and human retrovirusesGp41 and p24 IgG Binding Antibody Titers Are Associated with HIV-1 Viral Control during Early HIV-1 Subtype C Infection. AIDS Res Hum Retroviruses. 2014 Oct; 30 Suppl 1:A248.AIDS Res Hum Retroviruses2014-10-01T00:00:002014Gp41 and p24 IgG Binding Antibody Titers Are Associated with HIV-1 Viral Control during Early HIV-1 Subtype C Infection.25357593Mabuka JK, Dugast AS, Euler Z, Ramlakhan Y, Dong K, Walker BD, Ndung'u T, Alter GAIDS research and human retrovirusesAcute HIV-1 Subtype C Infection Is Associated with Rapid Increase of Tissue-like Memory and Decrease in Resting Memory B-cells. AIDS Res Hum Retroviruses. 2014 Oct; 30 Suppl 1:A211.AIDS Res Hum Retroviruses2014-10-01T00:00:002014Acute HIV-1 Subtype C Infection Is Associated with Rapid Increase of Tissue-like Memory and Decrease in Resting Memory B-cells.25357834Dugast AS, Arnold K, Hoffner M, Pereyra F, Seaman M, Walker B, Lauffenburger D, Alter GAIDS research and human retrovirusesAn Inflammatory Profile that Predicts the Development of Neutralizing Antibody Breadth. AIDS Res Hum Retroviruses. 2014 Oct; 30 Suppl 1:A35-6.AIDS Res Hum Retroviruses2014-10-01T00:00:002014An Inflammatory Profile that Predicts the Development of Neutralizing Antibody Breadth.25357881Byrne EH, Anahtar M, Doherty K, Olson G, Bowman B, Padavattan N, Ndhlovu Z, Ghebremichael M, Walker B, Ndung'u T, Dong K, Kwon DSAIDS research and human retrovirusesInjectable Contraceptive Use Correlates with Increased HIV Target Cells at the Cervix in Young South African Women. AIDS Res Hum Retroviruses. 2014 Oct; 30 Suppl 1:A54-5.AIDS Res Hum Retroviruses2014-10-01T00:00:002014Injectable Contraceptive Use Correlates with Increased HIV Target Cells at the Cervix in Young South African Women.25165115Pereyra F, Heckerman D, Carlson JM, Kadie C, Soghoian DZ, Karel D, Goldenthal A, Davis OB, DeZiel CE, Lin T, Peng J, Piechocka A, Carrington M, Walker BDJournal of virologyHIV control is mediated in part by CD8+ T-cell targeting of specific epitopes. J Virol. 2014 Nov; 88(22):12937-48.J Virol2014-08-27T00:00:002014HIV control is mediated in part by CD8+ T-cell targeting of specific epitopes.Authorship 789842Authorship 768397224713650Wang LW, Walker BD, Omari A, Tay AE, Subbiah RNEuropean heart journalMetastatic Merkel cell carcinoma of the heart. Eur Heart J. 2014 Nov 01; 35(41):2927.Eur Heart J2014-04-07T00:00:002014Metastatic Merkel cell carcinoma of the heart.Authorship 42065011Authorship 2466315Authorship 35952818Authorship 36264727Authorship 3683384Authorship 43393711Authorship 4349238Authorship 44857113Authorship 4487855Authorship 7730641325193656Mann JK, Chopera D, Omarjee S, Kuang XT, Le AQ, Anmole G, Danroth R, Mwimanzi P, Reddy T, Carlson J, Radebe M, Goulder PJR, Walker BD, Abdool Karim S, Novitsky V, Williamson C, Brockman MA, Brumme ZL, Ndung'u TVirologyNef-mediated down-regulation of CD4 and HLA class I in HIV-1 subtype C infection: association with disease progression and influence of immune pressure. Virology. 2014 Nov; 468-470:214-225.Virology2014-09-03T00:00:002014Nef-mediated down-regulation of CD4 and HLA class I in HIV-1 subtype C infection: association with disease progression and influence of immune pressure.Authorship 483334Authorship 77551316Authorship 775487725453107Payne R, Muenchhoff M, Mann J, Roberts HE, Matthews P, Adland E, Hempenstall A, Huang KH, Brockman M, Brumme Z, Sinclair M, Miura T, Frater J, Essex M, Shapiro R, Walker BD, Ndung'u T, McLean AR, Carlson JM, Goulder PJProceedings of the National Academy of Sciences of the United States of AmericaImpact of HLA-driven HIV adaptation on virulence in populations of high HIV seroprevalence. Proc Natl Acad Sci U S A. 2014 Dec 16; 111(50):E5393-400.Proc Natl Acad Sci U S A2014-12-01T00:00:002014Impact of HLA-driven HIV adaptation on virulence in populations of high HIV seroprevalence.Authorship 521484325526311Gaiha GD, McKim KJ, Woods M, Pertel T, Rohrbach J, Barteneva N, Chin CR, Liu D, Soghoian DZ, Cesa K, Wilton S, Waring MT, Chicoine A, Doering T, Wherry EJ, Kaufmann DE, Lichterfeld M, Brass AL, Walker BDImmunityDysfunctional HIV-specific CD8+ T cell proliferation is associated with increased caspase-8 activity and mediated by necroptosis. Immunity. 2014 Dec 18; 41(6):1001-12.Immunity2014-12-08T00:00:002014Dysfunctional HIV-specific CD8+ T cell proliferation is associated with increased caspase-8 activity and mediated by necroptosis.Authorship 534236Authorship 55009817Authorship 7777649Authorship 7787251925387316Radebe M, Gounder K, Mokgoro M, Ndhlovu ZM, Mncube Z, Mkhize L, van der Stok M, Jaggernath M, Walker BD, Ndung'u TAIDS (London, England)Broad and persistent Gag-specific CD8+ T-cell responses are associated with viral control but rarely drive viral escape during primary HIV-1 infection. AIDS. 2015 Jan 02; 29(1):23-33.AIDS2015-01-02T00:00:002015Broad and persistent Gag-specific CD8+ T-cell responses are associated with viral control but rarely drive viral escape during primary HIV-1 infection.Authorship 5164413Authorship 5172067Authorship 5657818Authorship 536342Authorship 7270113Authorship 887818Authorship 27795613Authorship 5223828Authorship 5235082Authorship 5475638Authorship 5625173Authorship 623026Authorship 890145Authorship 89907Authorship 989418Authorship 609427Authorship 860669Authorship 39526110Authorship 3997Authorship 4147486Authorship 3778656Authorship 41763612Authorship 4415456Authorship 3371211Authorship 4760492Authorship 2989509Authorship 48417613Authorship 4872323Authorship 52013118Authorship 38055123Authorship 48102223Authorship 5212507Authorship 52221222Authorship 4907031Authorship 18213717Authorship 23519120Authorship 580144Authorship 40061919Authorship 56061812Authorship 5078444Authorship 4023822Authorship 51276512Authorship 595237Authorship 6846314Authorship 4201877Authorship 4254858Authorship 1908916Authorship 5305513Authorship 27516017Authorship 2770521Authorship 854048Authorship 53849417Authorship 27858217Authorship 2472727Authorship 2534203Authorship 45024119Authorship 54251210Authorship 4801125Authorship 49154214Authorship 4944305Authorship 5172722Authorship 57332621Authorship 5541896Authorship 5555007Authorship 596637Authorship 577917Authorship 1750372Authorship 6525011Authorship 7389518Authorship 24715218Authorship 2496402Authorship 28008Authorship 3013122Authorship 1042931Authorship 30148713Authorship 2397858Authorship 3163498Authorship 2567918Authorship 208631Authorship 2098251Authorship 2432208Authorship 25772517Authorship 33926410Authorship 34599211Authorship 21765215Authorship 21853914Authorship 2495694Authorship 4332957Authorship 3606122Authorship 37720613Authorship 3947572Authorship 403831Authorship 4328804Authorship 43370641Authorship 4432011Authorship 19896613Authorship 25818715Authorship 38428811Authorship 3843432Authorship 2763948Authorship 3888342Authorship 31066614Authorship 5380089Authorship 5553438Authorship 57081120Authorship 5711539Authorship 577924Authorship 605208Authorship 627303Authorship 2469694Authorship 28416012Authorship 3324355Authorship 40548816Authorship 4124512Authorship 2238432Authorship 3992581325992865Anahtar MN, Byrne EH, Doherty KE, Bowman BA, Yamamoto HS, Soumillon M, Padavattan N, Ismail N, Moodley A, Sabatini ME, Ghebremichael MS, Nusbaum C, Huttenhower C, Virgin HW, Ndung'u T, Dong KL, Walker BD, Fichorova RN, Kwon DSImmunityCervicovaginal bacteria are a major modulator of host inflammatory responses in the female genital tract. Immunity. 2015 May 19; 42(5):965-76.Immunity2015-05-19T00:00:002015Cervicovaginal bacteria are a major modulator of host inflammatory responses in the female genital tract.Authorship 2766922Authorship 2797459Authorship 29244318Authorship 30961516Authorship 3229417Authorship 32523410Authorship 4201254Authorship 4479529Authorship 4594165Authorship 5107734Authorship 2312817Authorship 23346115Authorship 577825Authorship 28321316Authorship 4643422Authorship 3225478Authorship 33368110Authorship 34571614Authorship 36367010Authorship 37135111Authorship 37160412Authorship 42652811Authorship 4532459Authorship 4590103Authorship 45929314Authorship 48541315Authorship 53272320Authorship 54436810Authorship 550214Authorship 79149917Authorship 79595613Authorship 79449815Authorship 79635312Authorship 8025949Authorship 80305211Authorship 7909541225717111Kikuchi T, Iwabu Y, Tada T, Kawana-Tachikawa A, Koga M, Hosoya N, Nomura S, Brumme ZL, Jessen H, Pereyra F, Trocha A, Walker BD, Iwamoto A, Tokunaga K, Miura TJournal of virologyAnti-APOBEC3G activity of HIV-1 Vif protein is attenuated in elite controllers. J Virol. 2015 May; 89(9):4992-5001.J Virol2015-02-25T00:00:002015Anti-APOBEC3G activity of HIV-1 Vif protein is attenuated in elite controllers.25793728Chen J, Tibroni N, Sauter D, Galaski J, Miura T, Alter G, Mueller B, Haller C, Walker BD, Kirchhoff F, Brumme ZL, Ueno T, Fackler OTPloS oneModest attenuation of HIV-1 Vpu alleles derived from elite controller plasma. PLoS One. 2015; 10(3):e0120434.PLoS One2015-03-20T00:00:002015Modest attenuation of HIV-1 Vpu alleles derived from elite controller plasma.25635456Cohn LB, Silva IT, Oliveira TY, Rosales RA, Parrish EH, Learn GH, Hahn BH, Czartoski JL, McElrath MJ, Lehmann C, Klein F, Caskey M, Walker BD, Siliciano JD, Siliciano RF, Jankovic M, Nussenzweig MCCellHIV-1 integration landscape during latent and active infection. Cell. 2015 Jan 29; 160(3):420-32.Cell2015-01-29T00:00:002015HIV-1 integration landscape during latent and active infection.25911754Kløverpris HN, McGregor R, McLaren JE, Ladell K, Harndahl M, Stryhn A, Carlson JM, Koofhethile C, Gerritsen B, Kesmir C, Chen F, Riddell L, Luzzi G, Leslie A, Walker BD, Ndung'u T, Buus S, Price DA, Goulder PJJournal of immunology (Baltimore, Md. : 1950)CD8+ TCR Bias and Immunodominance in HIV-1 Infection. J Immunol. 2015 Jun 01; 194(11):5329-45.J Immunol2015-04-24T00:00:002015CD8+ TCR Bias and Immunodominance in HIV-1 Infection.25781986Gounder K, Padayachi N, Mann JK, Radebe M, Mokgoro M, van der Stok M, Mkhize L, Mncube Z, Jaggernath M, Reddy T, Walker BD, Ndung'u TPloS oneHigh frequency of transmitted HIV-1 Gag HLA class I-driven immune escape variants but minimal immune selection over the first year of clade C infection. PLoS One. 2015; 10(3):e0119886.PLoS One2015-03-17T00:00:002015High frequency of transmitted HIV-1 Gag HLA class I-driven immune escape variants but minimal immune selection over the first year of clade C infection.26045439Xu GJ, Kula T, Xu Q, Li MZ, Vernon SD, Ndung'u T, Ruxrungtham K, Sanchez J, Brander C, Chung RT, O'Connor KC, Walker B, Larman HB, Elledge SJScience (New York, N.Y.)Viral immunology. Comprehensive serological profiling of human populations using a synthetic human virome. Science. 2015 Jun 05; 348(6239):aaa0698.Science2015-06-05T00:00:002015Viral immunology. Comprehensive serological profiling of human populations using a synthetic human virome.Authorship 5832213Authorship 6306610Authorship 632343Authorship 7905715Authorship 856681Authorship 2580527Authorship 2641224Authorship 28785716Authorship 31344813Authorship 3207819Authorship 3290707Authorship 33158919Authorship 27064310Authorship 30186211Authorship 3204978Authorship 328188Authorship 33349218Authorship 3391039Authorship 3449614Authorship 40047111Authorship 4361542Authorship 4886301Authorship 4991732Authorship 53123110Authorship 3741462Authorship 3741959Authorship 38754510Authorship 4628119Authorship 4649419Authorship 52521514Authorship 55934610Authorship 8122097Authorship 80821614Authorship 80801419Authorship 8118892026067651Martin-Gayo E, Buzon MJ, Ouyang Z, Hickman T, Cronin J, Pimenova D, Walker BD, Lichterfeld M, Yu XGPLoS pathogensPotent Cell-Intrinsic Immune Responses in Dendritic Cells Facilitate HIV-1-Specific T Cell Immunity in HIV-1 Elite Controllers. PLoS Pathog. 2015 Jun; 11(6):e1004930.PLoS Pathog2015-06-11T00:00:002015Potent Cell-Intrinsic Immune Responses in Dendritic Cells Facilitate HIV-1-Specific T Cell Immunity in HIV-1 Elite Controllers.26076345Adland E, Paioni P, Thobakgale C, Laker L, Mori L, Muenchhoff M, Csala A, Clapson M, Flynn J, Novelli V, Hurst J, Naidoo V, Shapiro R, Huang KH, Frater J, Prendergast A, Prado JG, Ndung'u T, Walker BD, Carrington M, Jooste P, Goulder PJPLoS pathogensDiscordant Impact of HLA on Viral Replicative Capacity and Disease Progression in Pediatric and Adult HIV Infection. PLoS Pathog. 2015 Jun; 11(6):e1004954.PLoS Pathog2015-06-15T00:00:002015Discordant Impact of HLA on Viral Replicative Capacity and Disease Progression in Pediatric and Adult HIV Infection.26108174Adoro S, Cubillos-Ruiz JR, Chen X, Deruaz M, Vrbanac VD, Song M, Park S, Murooka TT, Dudek TE, Luster AD, Tager AM, Streeck H, Bowman B, Walker BD, Kwon DS, Lazarevic V, Glimcher LHNature communicationsIL-21 induces antiviral microRNA-29 in CD4 T cells to limit HIV-1 infection. Nat Commun. 2015 Jun 25; 6:7562.Nat Commun2015-06-25T00:00:002015IL-21 induces antiviral microRNA-29 in CD4 T cells to limit HIV-1 infection.25855300Caskey M, Klein F, Lorenzi JC, Seaman MS, West AP, Buckley N, Kremer G, Nogueira L, Braunschweig M, Scheid JF, Horwitz JA, Shimeliovich I, Ben-Avraham S, Witmer-Pack M, Platten M, Lehmann C, Burke LA, Hawthorne T, Gorelick RJ, Walker BD, Keler T, Gulick RM, Fätkenheuer G, Schlesinger SJ, Nussenzweig MCNatureViraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117. Nature. 2015 06 25; 522(7557):487-91.Nature2015-04-08T00:00:002015Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117.Authorship 2913321Authorship 81395620Authorship 8150635Authorship 8143031326157156Thobakgale CF, Prendergast A, Crawford H, Mkhwanazi N, Ramduth D, Reddy S, Molina C, Mncube Z, Leslie A, Prado J, Chonco F, Mphatshwe W, Tudor-Williams G, Jeena P, Blanckenberg N, Dong K, Kiepiela P, Coovadia H, Ndung'u T, Walker BD, Goulder PJJournal of virologyCorrection for Thobakgale et al., Impact of HLA in Mother and Child on Disease Progression of Pediatric Human Immunodeficiency Virus Type 1 Infection. J Virol. 2015 Aug; 89(15):8101.J Virol2015-07-08T00:00:002015Correction for Thobakgale et al., Impact of HLA in Mother and Child on Disease Progression of Pediatric Human Immunodeficiency Virus Type 1 Infection.26151555Mori M, Adland E, Paioni P, Swordy A, Mori L, Laker L, Muenchhoff M, Matthews PC, Tudor-Williams G, Lavandier N, van Zyl A, Hurst J, Walker BD, Ndung'u T, Prendergast A, Goulder P, Jooste PPloS oneSex Differences in Antiretroviral Therapy Initiation in Pediatric HIV Infection. PLoS One. 2015; 10(7):e0131591.PLoS One2015-07-07T00:00:002015Sex Differences in Antiretroviral Therapy Initiation in Pediatric HIV Infection.25995260Vigano S, Negron J, Ouyang Z, Rosenberg ES, Walker BD, Lichterfeld M, Yu XGJournal of virologyProlonged Antiretroviral Therapy Preserves HIV-1-Specific CD8 T Cells with Stem Cell-Like Properties. J Virol. 2015 Aug; 89(15):7829-40.J Virol2015-05-20T00:00:002015Prolonged Antiretroviral Therapy Preserves HIV-1-Specific CD8 T Cells with Stem Cell-Like Properties.Authorship 3062745Authorship 31318111Authorship 3154368Authorship 35758511Authorship 821107425940215Lee W, Tay A, Subbiah RN, Walker BD, Kuchar DL, Muthiah K, Macdonald PS, Keogh AM, Kotlyar E, Jabbour A, Spratt P, Jansz PC, Granger E, Dhital K, Hayward CSPacing and clinical electrophysiology : PACEImpact of Implantable Cardioverter Defibrillators on Survival of Patients with Centrifugal Left Ventricular Assist Devices. Pacing Clin Electrophysiol. 2015 Aug; 38(8):925-33.Pacing Clin Electrophysiol2015-05-31T00:00:002015Impact of Implantable Cardioverter Defibrillators on Survival of Patients with Centrifugal Left Ventricular Assist Devices.Authorship 45326326Authorship 825132826178998Toyoda M, Ogata Y, Mahiti M, Maeda Y, Kuang XT, Miura T, Jessen H, Walker BD, Brockman MA, Brumme ZL, Ueno TJournal of virologyDifferential Ability of Primary HIV-1 Nef Isolates To Downregulate HIV-1 Entry Receptors. J Virol. 2015 Sep; 89(18):9639-52.J Virol2015-07-15T00:00:002015Differential Ability of Primary HIV-1 Nef Isolates To Downregulate HIV-1 Entry Receptors.Authorship 5149249Authorship 5191742Authorship 52715615Authorship 55779717Authorship 59620726362266Ndhlovu ZM, Kamya P, Mewalal N, Kløverpris HN, Nkosi T, Pretorius K, Laher F, Ogunshola F, Chopera D, Shekhar K, Ghebremichael M, Ismail N, Moodley A, Malik A, Leslie A, Goulder PJ, Buus S, Chakraborty A, Dong K, Ndung'u T, Walker BDImmunityMagnitude and Kinetics of CD8+ T Cell Activation during Hyperacute HIV Infection Impact Viral Set Point. Immunity. 2015 Sep 15; 43(3):591-604.Immunity2015-09-08T00:00:002015Magnitude and Kinetics of CD8+ T Cell Activation during Hyperacute HIV Infection Impact Viral Set Point.Authorship 83299021Authorship 766798Authorship 8388971226269189Ndhlovu ZM, Stampouloglou E, Cesa K, Mavrothalassitis O, Alvino DM, Li JZ, Wilton S, Karel D, Piechocka-Trocha A, Chen H, Pereyra F, Walker BDJournal of virologyThe Breadth of Expandable Memory CD8+ T Cells Inversely Correlates with Residual Viral Loads in HIV Elite Controllers. J Virol. 2015 Nov; 89(21):10735-47.J Virol2015-08-12T00:00:002015The Breadth of Expandable Memory CD8+ T Cells Inversely Correlates with Residual Viral Loads in HIV Elite Controllers.Authorship 37574117Authorship 4344862Authorship 44388916Authorship 8426341526516768Freund NT, Horwitz JA, Nogueira L, Sievers SA, Scharf L, Scheid JF, Gazumyan A, Liu C, Velinzon K, Goldenthal A, Sanders RW, Moore JP, Bjorkman PJ, Seaman MS, Walker BD, Klein F, Nussenzweig MCPLoS pathogensA New Glycan-Dependent CD4-Binding Site Neutralizing Antibody Exerts Pressure on HIV-1 In Vivo. PLoS Pathog. 2015 Oct; 11(10):e1005238.PLoS Pathog2015-10-30T00:00:002015A New Glycan-Dependent CD4-Binding Site Neutralizing Antibody Exerts Pressure on HIV-1 In Vivo.Authorship 4608899Authorship 5125698Authorship 84837232Authorship 8500041526553974McLaren PJ, Coulonges C, Bartha I, Lenz TL, Deutsch AJ, Bashirova A, Buchbinder S, Carrington MN, Cossarizza A, Dalmau J, De Luca A, Goedert JJ, Gurdasani D, Haas DW, Herbeck JT, Johnson EO, Kirk GD, Lambotte O, Luo M, Mallal S, van Manen D, Martinez-Picado J, Meyer L, Miro JM, Mullins JI, Obel N, Poli G, Sandhu MS, Schuitemaker H, Shea PR, Theodorou I, Walker BD, Weintrob AC, Winkler CA, Wolinsky SM, Raychaudhuri S, Goldstein DB, Telenti A, de Bakker PI, Zagury JF, Fellay JProceedings of the National Academy of Sciences of the United States of AmericaPolymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load. Proc Natl Acad Sci U S A. 2015 Nov 24; 112(47):14658-63.Proc Natl Acad Sci U S A2015-11-09T00:00:002015Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load.26575988Hölzemer A, Thobakgale CF, Jimenez Cruz CA, Garcia-Beltran WF, Carlson JM, van Teijlingen NH, Mann JK, Jaggernath M, Kang SG, Körner C, Chung AW, Schafer JL, Evans DT, Alter G, Walker BD, Goulder PJ, Carrington M, Hartmann P, Pertel T, Zhou R, Ndung'u T, Altfeld MPLoS medicineSelection of an HLA-C*03:04-Restricted HIV-1 p24 Gag Sequence Variant Is Associated with Viral Escape from KIR2DL3+ Natural Killer Cells: Data from an Observational Cohort in South Africa. PLoS Med. 2015 Nov; 12(11):e1001900; discussion e1001900.PLoS Med2015-11-17T00:00:002015Selection of an HLA-C*03:04-Restricted HIV-1 p24 Gag Sequence Variant Is Associated with Viral Escape from KIR2DL3+ Natural Killer Cells: Data from an Observational Cohort in South Africa.26559841Kinloch NN, MacMillan DR, Le AQ, Cotton LA, Bangsberg DR, Buchbinder S, Carrington M, Fuchs J, Harrigan PR, Koblin B, Kushel M, Markowitz M, Mayer K, Milloy MJ, Schechter MT, Wagner T, Walker BD, Carlson JM, Poon AF, Brumme ZLJournal of virologyPopulation-Level Immune-Mediated Adaptation in HIV-1 Polymerase during the North American Epidemic. J Virol. 2016 02 01; 90(3):1244-58.J Virol2015-11-11T00:00:002015Population-Level Immune-Mediated Adaptation in HIV-1 Polymerase during the North American Epidemic.Authorship 5289926Authorship 850555726623655Heesters BA, Lindqvist M, Vagefi PA, Scully EP, Schildberg FA, Altfeld M, Walker BD, Kaufmann DE, Carroll MCPLoS pathogensFollicular Dendritic Cells Retain Infectious HIV in Cycling Endosomes. PLoS Pathog. 2015 Dec; 11(12):e1005285.PLoS Pathog2015-12-01T00:00:002015Follicular Dendritic Cells Retain Infectious HIV in Cycling Endosomes.Authorship 8532681526658814Makadzange AT, Higgins-Biddle M, Chimukangara B, Birri R, Gordon M, Mahlanza T, McHugh G, van Dijk JH, Bwakura-Dangarembizi M, Ndung'u T, Masimirembwa C, Phelps B, Amzel A, Ojikutu BO, Walker BD, Ndhlovu CEPloS oneClinical, Virologic, Immunologic Outcomes and Emerging HIV Drug Resistance Patterns in Children and Adolescents in Public ART Care in Zimbabwe. PLoS One. 2015; 10(12):e0144057.PLoS One2015-12-14T00:00:002015Clinical, Virologic, Immunologic Outcomes and Emerging HIV Drug Resistance Patterns in Children and Adolescents in Public ART Care in Zimbabwe.Authorship 43674917Authorship 453862026723758Byrne EH, Anahtar MN, Cohen KE, Moodley A, Padavattan N, Ismail N, Bowman BA, Olson GS, Mabhula A, Leslie A, Ndung'u T, Walker BD, Ghebremichael MS, Dong KL, Kwon DSThe Lancet. Infectious diseasesAssociation between injectable progestin-only contraceptives and HIV acquisition and HIV target cell frequency in the female genital tract in South African women: a prospective cohort study. Lancet Infect Dis. 2016 Apr; 16(4):441-8.Lancet Infect Dis2015-12-24T00:00:002015Association between injectable progestin-only contraceptives and HIV acquisition and HIV target cell frequency in the female genital tract in South African women: a prospective cohort study.26656715Ranasinghe S, Soghoian DZ, Lindqvist M, Ghebremichael M, Donaghey F, Carrington M, Seaman MS, Kaufmann DE, Walker BD, Porichis FJournal of virologyHIV-1 Antibody Neutralization Breadth Is Associated with Enhanced HIV-Specific CD4+ T Cell Responses. J Virol. 2015 Dec 09; 90(5):2208-20.J Virol2015-12-09T00:00:002015HIV-1 Antibody Neutralization Breadth Is Associated with Enhanced HIV-Specific CD4+ T Cell Responses.Authorship 4721859Authorship 48615292008-08-08T00:00:002008-06-16T00:00:00Assessment of technical difficulties in amplifying and sequencing HIV and developmet of new work protocol for sequencingInternationalAuthorship 5502299Authorship 5503324Authorship 5533508Authorship 8581685Authorship 8579357Authorship 8606701726787826Mahiti M, Toyoda M, Jia X, Kuang XT, Mwimanzi F, Mwimanzi P, Walker BD, Xiong Y, Brumme ZL, Brockman MA, Ueno TmBioRelative Resistance of HLA-B to Downregulation by Naturally Occurring HIV-1 Nef Sequences. mBio. 2016 Jan 19; 7(1):e01516-15.mBio2016-01-19T00:00:002016Relative Resistance of HLA-B to Downregulation by Naturally Occurring HIV-1 Nef Sequences.26745376Ackerman ME, Mikhailova A, Brown EP, Dowell KG, Walker BD, Bailey-Kellogg C, Suscovich TJ, Alter GPLoS pathogensPolyfunctional HIV-Specific Antibody Responses Are Associated with Spontaneous HIV Control. PLoS Pathog. 2016 Jan; 12(1):e1005315.PLoS Pathog2016-01-08T00:00:002016Polyfunctional HIV-Specific Antibody Responses Are Associated with Spontaneous HIV Control.2005-01-30T00:00:002005-01-03T00:00:00Clinical Elective at McCord Hospital, Durban, South Africa, January 2005InternationalAuthorship 86771020Authorship 86878124Authorship 86204012Authorship 8698222Authorship 870719926379068Gandhi RT, Kwon DS, Macklin EA, Shopis JR, McLean AP, McBrine N, Flynn T, Peter L, Sbrolla A, Kaufmann DE, Porichis F, Walker BD, Bhardwaj N, Barouch DH, Kavanagh DGJournal of acquired immune deficiency syndromes (1999)Immunization of HIV-1-Infected Persons With Autologous Dendritic Cells Transfected With mRNA Encoding HIV-1 Gag and Nef: Results of a Randomized, Placebo-Controlled Clinical Trial. J Acquir Immune Defic Syndr. 2016 Mar 01; 71(3):246-53.J Acquir Immune Defic Syndr2016-03-01T00:00:002016Immunization of HIV-1-Infected Persons With Autologous Dendritic Cells Transfected With mRNA Encoding HIV-1 Gag and Nef: Results of a Randomized, Placebo-Controlled Clinical Trial.26908875Havenar-Daughton C, Lindqvist M, Heit A, Wu JE, Reiss SM, Kendric K, Bélanger S, Kasturi SP, Landais E, Akondy RS, McGuire HM, Bothwell M, Vagefi PA, Scully E, Tomaras GD, Davis MM, Poignard P, Ahmed R, Walker BD, Pulendran B, McElrath MJ, Kaufmann DE, Crotty SProceedings of the National Academy of Sciences of the United States of AmericaCXCL13 is a plasma biomarker of germinal center activity. Proc Natl Acad Sci U S A. 2016 Mar 08; 113(10):2702-7.Proc Natl Acad Sci U S A2016-02-23T00:00:002016CXCL13 is a plasma biomarker of germinal center activity.26850658Kløverpris HN, Kazer SW, Mjösberg J, Mabuka JM, Wellmann A, Ndhlovu Z, Yadon MC, Nhamoyebonde S, Muenchhoff M, Simoni Y, Andersson F, Kuhn W, Garrett N, Burgers WA, Kamya P, Pretorius K, Dong K, Moodley A, Newell EW, Kasprowicz V, Abdool Karim SS, Goulder P, Shalek AK, Walker BD, Ndung'u T, Leslie AImmunityInnate Lymphoid Cells Are Depleted Irreversibly during Acute HIV-1 Infection in the Absence of Viral Suppression. Immunity. 2016 Feb 16; 44(2):391-405.Immunity2016-02-02T00:00:002016Innate Lymphoid Cells Are Depleted Irreversibly during Acute HIV-1 Infection in the Absence of Viral Suppression.26731469Jones RB, Walker BDThe Journal of clinical investigationHIV-specific CD8? T cells and HIV eradication. J Clin Invest. 2016 Feb; 126(2):455-63.J Clin Invest2016-01-05T00:00:002016HIV-specific CD8? T cells and HIV eradication.Authorship 9575913Authorship 9789212Authorship 6193252003-08-31T00:00:002003-06-23T00:00:00The Influence of the Availability of ARV Therapy on Doctor’s
Relationship with Patients with HIVInternational/Summer2004-08-24T00:00:002004-06-24T00:00:00Investigation of Health Care Management Procedures for HIV/AIDS Clinic Scale-up of Antiretroviral Treatment with PEPFAR FundingInternationalAuthorship 6364221Authorship 296951102005-01-30T00:00:002005-01-03T00:00:00Clinical Elective at McCord Hospital, Durban, South Africa, January 2005International2005-03-31T00:00:002005-01-30T00:00:00Clinical Research at McCord Hospital, Durban, South Africa, spring 2005InternationalAuthorship 33337512Authorship 8718681326982805Mahan AE, Jennewein MF, Suscovich T, Dionne K, Tedesco J, Chung AW, Streeck H, Pau M, Schuitemaker H, Francis D, Fast P, Laufer D, Walker BD, Baden L, Barouch DH, Alter GPLoS pathogensAntigen-Specific Antibody Glycosylation Is Regulated via Vaccination. PLoS Pathog. 2016 Mar; 12(3):e1005456.PLoS Pathog2016-03-16T00:00:002016Antigen-Specific Antibody Glycosylation Is Regulated via Vaccination.Authorship 36734714Authorship 3717298Authorship 87435512Authorship 38043121Authorship 8780522627082643Jones RB, Mueller S, O'Connor R, Rimpel K, Sloan DD, Karel D, Wong HC, Jeng EK, Thomas AS, Whitney JB, Lim SY, Kovacs C, Benko E, Karandish S, Huang SH, Buzon MJ, Lichterfeld M, Irrinki A, Murry JP, Tsai A, Yu H, Geleziunas R, Trocha A, Ostrowski MA, Irvine DJ, Walker BDPLoS pathogensA Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4+ T-Cells to Recognition by Cytotoxic T-Lymphocytes. PLoS Pathog. 2016 Apr; 12(4):e1005545.PLoS Pathog2016-04-15T00:00:002016A Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4+ T-Cells to Recognition by Cytotoxic T-Lymphocytes.Authorship 4337331Authorship 436327227163788Tully DC, Ogilvie CB, Batorsky RE, Bean DJ, Power KA, Ghebremichael M, Bedard HE, Gladden AD, Seese AM, Amero MA, Lane K, McGrath G, Bazner SB, Tinsley J, Lennon NJ, Henn MR, Brumme ZL, Norris PJ, Rosenberg ES, Mayer KH, Jessen H, Kosakovsky Pond SL, Walker BD, Altfeld M, Carlson JM, Allen TMPLoS pathogensDifferences in the Selection Bottleneck between Modes of Sexual Transmission Influence the Genetic Composition of the HIV-1 Founder Virus. PLoS Pathog. 2016 05; 12(5):e1005619.PLoS Pathog2016-05-10T00:00:002016Differences in the Selection Bottleneck between Modes of Sexual Transmission Influence the Genetic Composition of the HIV-1 Founder Virus.Authorship 4476477Authorship 47535792012-08-15T00:00:002012-06-15T00:00:00Serum markers for immune activation in HIV-1 subtype C infected adultsInternational/SummerAuthorship 88246611Authorship 8822102327173934Apps R, Del Prete GQ, Chatterjee P, Lara A, Brumme ZL, Brockman MA, Neil S, Pickering S, Schneider DK, Piechocka-Trocha A, Walker BD, Thomas R, Shaw GM, Hahn BH, Keele BF, Lifson JD, Carrington MCell host & microbeHIV-1 Vpu Mediates HLA-C Downregulation. Cell Host Microbe. 2016 May 11; 19(5):686-95.Cell Host Microbe2016-05-11T00:00:002016HIV-1 Vpu Mediates HLA-C Downregulation.2006-03-04T00:00:002006-01-07T00:00:00Clinical Elective at McCord Hospital in Durban, South AfricaInternationalAuthorship 5341106Authorship 883637427212475Barton JP, Goonetilleke N, Butler TC, Walker BD, McMichael AJ, Chakraborty AKNature communicationsRelative rate and location of intra-host HIV evolution to evade cellular immunity are predictable. Nat Commun. 2016 05 23; 7:11660.Nat Commun2016-05-23T00:00:002016Relative rate and location of intra-host HIV evolution to evade cellular immunity are predictable.Authorship 55706922Authorship 5669263Authorship 590942Authorship 5538935Authorship 5882922Assistant Professor0Full Professor5Other FacultyAuthorship 606933Authorship 61214727406996Shasha D, Karel D, Angiuli O, Greenblatt A, Ghebremichael M, Yu X, Porichis F, Walker BDJournal of leukocyte biologyElite controller CD8+ T cells exhibit comparable viral inhibition capacity, but better sustained effector properties compared to chronic progressors. J Leukoc Biol. 2016 12; 100(6):1425-1433.J Leukoc Biol2016-07-12T00:00:002016Elite controller CD8+ T cells exhibit comparable viral inhibition capacity, but better sustained effector properties compared to chronic progressors.Authorship 8903576Authorship 8917751027194762Koofhethile CK, Ndhlovu ZM, Thobakgale-Tshabalala C, Prado JG, Ismail N, Mncube Z, Mkhize L, van der Stok M, Yende N, Walker BD, Goulder PJR, Ndung'u TJournal of virologyCD8+ T Cell Breadth and Ex Vivo Virus Inhibition Capacity Distinguish between Viremic Controllers with and without Protective HLA Class I Alleles. J Virol. 2016 08 01; 90(15):6818-6831.J Virol2016-07-11T00:00:002016CD8+ T Cell Breadth and Ex Vivo Virus Inhibition Capacity Distinguish between Viremic Controllers with and without Protective HLA Class I Alleles.26951820Leitman EM, Hurst J, Mori M, Kublin J, Ndung'u T, Walker BD, Carlson J, Gray GE, Matthews PC, Frahm N, Goulder PJThe Journal of infectious diseasesLower Viral Loads and Slower CD4+ T-Cell Count Decline in MRKAd5 HIV-1 Vaccinees Expressing Disease-Susceptible HLA-B*58:02. J Infect Dis. 2016 08 01; 214(3):379-89.J Infect Dis2016-03-06T00:00:002016Lower Viral Loads and Slower CD4+ T-Cell Count Decline in MRKAd5 HIV-1 Vaccinees Expressing Disease-Susceptible HLA-B*58:02.Authorship 5676332Authorship 5676851Authorship 581147Authorship 608932Authorship 615212Authorship 8952283027338952Scheid JF, Horwitz JA, Bar-On Y, Kreider EF, Lu CL, Lorenzi JC, Feldmann A, Braunschweig M, Nogueira L, Oliveira T, Shimeliovich I, Patel R, Burke L, Cohen YZ, Hadrigan S, Settler A, Witmer-Pack M, West AP, Juelg B, Keler T, Hawthorne T, Zingman B, Gulick RM, Pfeifer N, Learn GH, Seaman MS, Bjorkman PJ, Klein F, Schlesinger SJ, Walker BD, Hahn BH, Nussenzweig MC, Caskey MNatureHIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption. Nature. 2016 07 28; 535(7613):556-60.Nature2016-06-22T00:00:002016HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption.Authorship 52128016Authorship 5279409Authorship 563969Authorship 610766Authorship 622129Authorship 622922Authorship 5575709Authorship 5764345Authorship 5983482008-06-30JOHNSTON, ROBERT E.2001-09-28Therapeutic Vaccination for HIV Using VEE VectorsP01AI0502462006-04-30WALKER, BRUCE D1991-08-01CELL-MEDIATED IMMUNITY IN HEPATITIS C VIRUS INFECTIONR01AI0315632015-07-31ALLEN, TODD M2008-09-26Acute HIV Infection: Implications for vaccine designP01AI0744151999-08-31VOLENEC, JERRY1995-09-01CORE--MANUFACTURINGU19AI0385841990-05-31WALKER, BRUCE D1985-12-01MECHANISM OF DES TRANSPLACENTAL CARCINOGENESISR01CA0415992008-07-312003-08-01HLA Typing and Epitope Mapping Relative to HIV Vaccine DesignN01AI300242019-12-31IRVINE, DARRELL J2014-04-01T-cell-mediated targeting of therapeutics to HIV reservoirsR01AI1118602005-06-30WALKER, BRUCE D1999-07-15IMMUNE CONTROL OF HIV REPLICATIONR01AI0446562007-10-30ROSENBERG, ERIC S1997-09-30HIV-1-specific CD4 Cells in Disease PathogenesisR01AI0408732002-11-30WALKER, BRUCE E1989-05-01TRANSPLACENTAL CARCINOGENESIS AND DIETR01CA0394562016-07-31LAUER, GEORG MICHAEL2005-08-17Immune Control and Evasion during Acute HCV InfectionU19AI0663452011-06-04WALKER, BRUCE D2006-02-01Pathogenesis of Clade C HIV InfectionR01AI0670732015-01-31WALKER, BRUCE D1991-01-01Inhibition of HIV 1 Replication by Cytotoxic LymphocytesR01AI0309142021-05-31WALKER, BRUCE D2005-07-01Pathogenesis of Clade C HIV InfectionR37AI0670732004-08-31WALKER, BRUCE D2002-09-15Development of a Microarray for CTL DetectionR21AI0539112024-07-31GANDHI, RAJESH T2004-07-01Harvard University Center for AIDS ResearchP30AI0603542013-08-31AHMED, RAFI2008-09-22PD-1 Function, Signaling, and Regulation During Viral InfectionP01AI0801922004-03-31WALKER, BRUCE D1989-07-01HIV 1 SPECIFIC T CELL CLONESR37AI0285681998-04-30WALKER, BRUCE D1994-08-01IMMUNE RECONSTITUTION IN AIDS VIRUS INFECTIONSR01AI0365501996-07-31WALKER, BRUCE D1991-09-30HIV 1 SPECIFIC IMMUNITY AND MATERNAL-FETAL TRANSMISSIONR01AI0324692009-03-31WALKER, BRUCE D1989-07-01HIV 1 specific T cell clonesR01AI0285682006-06-30WALKER, BRUCE D2000-09-29PARTNERS/FENWAY/SHATTUCK CENTER FOR AIDS RESEARCHP30AI0428511998-03-31DESROSIERS, RONALD C1900-01-01LIVE ATTENUATED MULTIPLY DELETED HIV-1 VACCINE FOR AIDSU01AI0353652008-06-30WALKER, BRUCE D2002-07-01PATHOGENESIS AND TREATMENT OF ACUTE HIV INFECTIONU01AI052403Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorCo-Principal InvestigatorPrincipal InvestigatorCo-Principal InvestigatorPrincipal InvestigatorCo-Principal InvestigatorCo-Principal InvestigatorCo-Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorCo-Principal InvestigatorCo-Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorCo-Principal InvestigatorCo-Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorAuthorship 6543713Authorship 91407442890916Clapp RW, Cobb S, Walker BLancet (London, England)Leukaemia near Massachusetts nuclear power plant. Lancet. 1987 Dec 05; 2(8571):1324-5.Lancet1987-12-05T00:00:001987Leukaemia near Massachusetts nuclear power plant.Authorship 78300727521484Sips M, Liu Q, Draghi M, Ghebremichael M, Berger CT, Suscovich TJ, Sun Y, Walker BD, Carrington M, Altfeld M, Brouckaert P, De Jager PL, Alter GHuman immunologyHLA-C levels impact natural killer cell subset distribution and function. Hum Immunol. 2016 Dec; 77(12):1147-1153.Hum Immunol2016-08-10T00:00:002016HLA-C levels impact natural killer cell subset distribution and function.Authorship 9156467Authorship 9152681227545045Baxter AE, Niessl J, Fromentin R, Richard J, Porichis F, Charlebois R, Massanella M, Brassard N, Alsahafi N, Delgado GG, Routy JP, Walker BD, Finzi A, Chomont N, Kaufmann DECell host & microbeSingle-Cell Characterization of Viral Translation-Competent Reservoirs in HIV-Infected Individuals. Cell Host Microbe. 2016 Sep 14; 20(3):368-380.Cell Host Microbe2016-08-18T00:00:002016Single-Cell Characterization of Viral Translation-Competent Reservoirs in HIV-Infected Individuals.27440904Rucevic M, Kourjian G, Boucau J, Blatnik R, Garcia Bertran W, Berberich MJ, Walker BD, Riemer AB, Le Gall SJournal of virologyAnalysis of Major Histocompatibility Complex-Bound HIV Peptides Identified from Various Cell Types Reveals Common Nested Peptides and Novel T Cell Responses. J Virol. 2016 10 01; 90(19):8605-20.J Virol2016-09-12T00:00:002016Analysis of Major Histocompatibility Complex-Bound HIV Peptides Identified from Various Cell Types Reveals Common Nested Peptides and Novel T Cell Responses.Authorship 916912227653598Gaiha GD, Walker BDImmunityCD8(+) T Cells and cART: A Dynamic Duo? Immunity. 2016 09 20; 45(3):466-468.Immunity2016-09-20T00:00:002016CD8(+) T Cells and cART: A Dynamic Duo?Authorship 602673Authorship 9180092527683550Muenchhoff M, Adland E, Karimanzira O, Crowther C, Pace M, Csala A, Leitman E, Moonsamy A, McGregor C, Hurst J, Groll A, Mori M, Sinmyee S, Thobakgale C, Tudor-Williams G, Prendergast AJ, Kloverpris H, Roider J, Leslie A, Shingadia D, Brits T, Daniels S, Frater J, Willberg CB, Walker BD, Ndung'u T, Jooste P, Moore PL, Morris L, Goulder PScience translational medicineNonprogressing HIV-infected children share fundamental immunological features of nonpathogenic SIV infection. Sci Transl Med. 2016 09 28; 8(358):358ra125.Sci Transl Med2016-09-28T00:00:002016Nonprogressing HIV-infected children share fundamental immunological features of nonpathogenic SIV infection.Authorship 938426Authorship 3648647Authorship 9234356Authorship 9236199Authorship 92475017Authorship 9245912227638468Li X, Lamothe PA, Ng R, Xu S, Teng M, Walker BD, Wang JHProtein & cellCrystal structure of HLA-B*5801, a protective HLA allele for HIV-1 infection. Protein Cell. 2016 10; 7(10):761-765.Protein Cell2016-10-01T00:00:002016Crystal structure of HLA-B*5801, a protective HLA allele for HIV-1 infection.26960182Gunn B, Schneider J, Shansab M, Bastian AR, Fahrbach K, Smith A, Mahan A, Karim M, Licht A, Zvonar I, Tedesco J, Anderson M, Chapel A, Suscovich T, Malaspina D, Streeck H, Walker BD, Kim A, Lauer G, Altfeld M, Pillai S, Szleifer I, Kelleher NL, Kiser PF, Hope TJ, Alter GMucosal immunologyEnhanced binding of antibodies generated during chronic HIV infection to mucus component MUC16. Mucosal Immunol. 2016 11; 9(6):1549-1558.Mucosal Immunol2016-03-09T00:00:002016Enhanced binding of antibodies generated during chronic HIV infection to mucus component MUC16.27760342Ranasinghe S, Lamothe PA, Soghoian DZ, Kazer SW, Cole MB, Shalek AK, Yosef N, Jones RB, Donaghey F, Nwonu C, Jani P, Clayton GM, Crawford F, White J, Montoya A, Power K, Allen TM, Streeck H, Kaufmann DE, Picker LJ, Kappler JW, Walker BDImmunityAntiviral CD8+ T Cells Restricted by Human Leukocyte Antigen Class II Exist during Natural HIV Infection and Exhibit Clonal Expansion. Immunity. 2016 10 18; 45(4):917-930.Immunity2016-10-18T00:00:002016Antiviral CD8+ T Cells Restricted by Human Leukocyte Antigen Class II Exist during Natural HIV Infection and Exhibit Clonal Expansion.27575385Kleinsteuber K, Corleis B, Rashidi N, Nchinda N, Lisanti A, Cho JL, Medoff BD, Kwon D, Walker BDCytometry. Part A : the journal of the International Society for Analytical CytologyStandardization and quality control for high-dimensional mass cytometry studies of human samples. Cytometry A. 2016 10; 89(10):903-913.Cytometry A2016-08-30T00:00:002016Standardization and quality control for high-dimensional mass cytometry studies of human samples.400 Technology SquareRagon Institute of MGH, MIT and HarvardRoom 870400 Technology SquareCambridge02139MAAuthorship 4730448Authorship 4859529Authorship 5074949Authorship 9298241427668293Lederman MM, Cannon PM, Currier JS, June CH, Kiem HP, Kuritzkes DR, Lewin SR, Margolis DM, McCune JM, Mellors JW, Schacker TW, Sekaly RP, Tebas P, Walker BD, Douek DCPathogens & immunityA Cure for HIV Infection: "Not in My Lifetime" or "Just Around the Corner"? Pathog Immun. 2016; 1(1):154-164.Pathog Immun2016-01-01T00:00:002016A Cure for HIV Infection: "Not in My Lifetime" or "Just Around the Corner"?Authorship 737876Authorship 809631Authorship 9117112Authorship 19583211Authorship 21401712Authorship 29678214Authorship 3129107Authorship 9399228Authorship 3808993Authorship 9417938Authorship 94167717Authorship 9439748Authorship 9415871Authorship 9432648Authorship 943255209253226Walker BJournal of health care for the poor and underservedPublic health in a managed care environment. J Health Care Poor Underserved. 1997 Aug; 8(3):345-50; discussion 350-1.J Health Care Poor Underserved1997-08-01T00:00:001997Public health in a managed care environment.27007847Caskey M, Klein F, Lorenzi JC, Seaman MS, West AP, Buckley N, Kremer G, Nogueira L, Braunschweig M, Scheid JF, Horwitz JA, Shimeliovich I, Ben-Avraham S, Witmer-Pack M, Platten M, Lehmann C, Burke LA, Hawthorne T, Gorelick RJ, Walker BD, Keler T, Gulick RM, Fätkenheuer G, Schlesinger SJ, Nussenzweig MCNatureCorrigendum: Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117. Nature. 2016 07 28; 535(7613):580.Nature2016-03-23T00:00:002016Corrigendum: Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117.27938646Palmer CD, Romero-Tejeda M, Scully EP, Lockhart A, Seaman MS, Goldenthal A, Piechocka-Trocha A, Walker BD, Chibnik LB, Jost S, Porichis FJournal of the International AIDS SocietyIncreased frequencies of CD8+CD57+ T cells are associated with antibody neutralization breadth against HIV in viraemic controllers. J Int AIDS Soc. 2016; 19(1):21136.J Int AIDS Soc2016-12-09T00:00:002016Increased frequencies of CD8+CD57+ T cells are associated with antibody neutralization breadth against HIV in viraemic controllers.27992415Park RJ, Wang T, Koundakjian D, Hultquist JF, Lamothe-Molina P, Monel B, Schumann K, Yu H, Krupzcak KM, Garcia-Beltran W, Piechocka-Trocha A, Krogan NJ, Marson A, Sabatini DM, Lander ES, Hacohen N, Walker BDNature geneticsA genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors. Nat Genet. 2017 Feb; 49(2):193-203.Nat Genet2016-12-19T00:00:002016A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors.27936416Jones RB, Mueller S, Kumari S, Vrbanac V, Genel S, Tager AM, Allen TM, Walker BD, Irvine DJBiomaterialsAntigen recognition-triggered drug delivery mediated by nanocapsule-functionalized cytotoxic T-cells. Biomaterials. 2017 02; 117:44-53.Biomaterials2016-11-25T00:00:002016Antigen recognition-triggered drug delivery mediated by nanocapsule-functionalized cytotoxic T-cells.2021-05-31WALKER, BRUCE D2015-06-15Molecular networks of HIV-specific CD4 T cell help to B cellsR01AI118544Co-Principal InvestigatorAuthorship 44711620Authorship 4589404Authorship 94879320Authorship 94970110Authorship 9495891028077649Flerin NC, Chen H, Glover TD, Lamothe PA, Zheng JH, Fang JW, Ndhlovu ZM, Newell EW, Davis MM, Walker BD, Goldstein HJournal of virologyT-Cell Receptor (TCR) Clonotype-Specific Differences in Inhibitory Activity of HIV-1 Cytotoxic T-Cell Clones Is Not Mediated by TCR Alone. J Virol. 2017 03 15; 91(6).J Virol2017-02-28T00:00:002017T-Cell Receptor (TCR) Clonotype-Specific Differences in Inhibitory Activity of HIV-1 Cytotoxic T-Cell Clones Is Not Mediated by TCR Alone.28087240Gosmann C, Anahtar MN, Handley SA, Farcasanu M, Abu-Ali G, Bowman BA, Padavattan N, Desai C, Droit L, Moodley A, Dong M, Chen Y, Ismail N, Ndung'u T, Ghebremichael MS, Wesemann DR, Mitchell C, Dong KL, Huttenhower C, Walker BD, Virgin HW, Kwon DSImmunityLactobacillus-Deficient Cervicovaginal Bacterial Communities Are Associated with Increased HIV Acquisition in Young South African Women. Immunity. 2017 01 17; 46(1):29-37.Immunity2017-01-10T00:00:002017Lactobacillus-Deficient Cervicovaginal Bacterial Communities Are Associated with Increased HIV Acquisition in Young South African Women.28077659Laher F, Ranasinghe S, Porichis F, Mewalal N, Pretorius K, Ismail N, Buus S, Stryhn A, Carrington M, Walker BD, Ndung'u T, Ndhlovu ZMJournal of virologyHIV Controllers Exhibit Enhanced Frequencies of Major Histocompatibility Complex Class II Tetramer+ Gag-Specific CD4+ T Cells in Chronic Clade C HIV-1 Infection. J Virol. 2017 04 01; 91(7).J Virol2017-03-13T00:00:002017HIV Controllers Exhibit Enhanced Frequencies of Major Histocompatibility Complex Class II Tetramer+ Gag-Specific CD4+ T Cells in Chronic Clade C HIV-1 Infection.Authorship 9508822228100831Freund NT, Wang H, Scharf L, Nogueira L, Horwitz JA, Bar-On Y, Golijanin J, Sievers SA, Sok D, Cai H, Cesar Lorenzi JC, Halper-Stromberg A, Toth I, Piechocka-Trocha A, Gristick HB, van Gils MJ, Sanders RW, Wang LX, Seaman MS, Burton DR, Gazumyan A, Walker BD, West AP, Bjorkman PJ, Nussenzweig MCScience translational medicineCoexistence of potent HIV-1 broadly neutralizing antibodies and antibody-sensitive viruses in a viremic controller. Sci Transl Med. 2017 01 18; 9(373).Sci Transl Med2017-01-18T00:00:002017Coexistence of potent HIV-1 broadly neutralizing antibodies and antibody-sensitive viruses in a viremic controller.Authorship 54433516Authorship 952130326847073Lee W, Tay A, Walker BD, Kuchar DL, Hayward CS, Spratt P, Subbiah RNEuropace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of CardiologyAccelerated graft dysfunction in heart transplant patients with persistent atrioventricular conduction block. Europace. 2016 Dec; 18(12):1837-1841.Europace2016-02-03T00:00:002016Accelerated graft dysfunction in heart transplant patients with persistent atrioventricular conduction block.Authorship 5684908Authorship 95567811Authorship 9547661328138558Martin-Gayo E, Cronin J, Hickman T, Ouyang Z, Lindqvist M, Kolb KE, Schulze Zur Wiesch J, Cubas R, Porichis F, Shalek AK, van Lunzen J, Haddad EK, Walker BD, Kaufmann DE, Lichterfeld M, Yu XGJCI insightCirculating CXCR5+CXCR3+PD-1lo Tfh-like cells in HIV-1 controllers with neutralizing antibody breadth. JCI Insight. 2017 01 26; 2(2):e89574.JCI Insight2017-01-26T00:00:002017Circulating CXCR5+CXCR3+PD-1lo Tfh-like cells in HIV-1 controllers with neutralizing antibody breadth.28158448Dugast AS, Arnold K, Lofano G, Moore S, Hoffner M, Simek M, Poignard P, Seaman M, Suscovich TJ, Pereyra F, Walker BD, Lauffenburger D, Kwon DS, Keele BF, Alter GClinical infectious diseases : an official publication of the Infectious Diseases Society of AmericaVirus-driven Inflammation Is Associated With the Development of bNAbs in Spontaneous Controllers of HIV. Clin Infect Dis. 2017 04 15; 64(8):1098-1104.Clin Infect Dis2017-04-15T00:00:002017Virus-driven Inflammation Is Associated With the Development of bNAbs in Spontaneous Controllers of HIV.Authorship 825473Authorship 904242Authorship 9674881285013Koziel MJ, Walker BDParasitologyViruses, chemotherapy and immunity. Parasitology. 1992; 105 Suppl:S85-92.Parasitology1992-01-01T00:00:001992Viruses, chemotherapy and immunity.8786327Harrer T, Harrer E, Kalams SA, Barbosa P, Trocha A, Johnson RP, Elbeik T, Feinberg MB, Buchbinder SP, Walker BDJournal of immunology (Baltimore, Md. : 1950)Cytotoxic T lymphocytes in asymptomatic long-term nonprogressing HIV-1 infection. Breadth and specificity of the response and relation to in vivo viral quasispecies in a person with prolonged infection and low viral load. J Immunol. 1996 Apr 01; 156(7):2616-23.J Immunol1996-04-01T00:00:001996Cytotoxic T lymphocytes in asymptomatic long-term nonprogressing HIV-1 infection. Breadth and specificity of the response and relation to in vivo viral quasispecies in a person with prolonged infection and low viral load.8743084Harrer T, Harrer E, Kalams SA, Elbeik T, Staprans SI, Feinberg MB, Cao Y, Ho DD, Yilma T, Caliendo AM, Johnson RP, Buchbinder SP, Walker BDAIDS research and human retrovirusesStrong cytotoxic T cell and weak neutralizing antibody responses in a subset of persons with stable nonprogressing HIV type 1 infection. AIDS Res Hum Retroviruses. 1996 May 01; 12(7):585-92.AIDS Res Hum Retroviruses1996-05-01T00:00:001996Strong cytotoxic T cell and weak neutralizing antibody responses in a subset of persons with stable nonprogressing HIV type 1 infection.10094651Rosenberg ES, Caliendo AM, Walker BDThe New England journal of medicineAcute HIV infection among patients tested for mononucleosis. N Engl J Med. 1999 Mar 25; 340(12):969.N Engl J Med1999-03-25T00:00:001999Acute HIV infection among patients tested for mononucleosis.10202022Brander C, Goulder PJ, Luzuriaga K, Yang OO, Hartman KE, Jones NG, Walker BD, Kalams SAJournal of immunology (Baltimore, Md. : 1950)Persistent HIV-1-specific CTL clonal expansion despite high viral burden post in utero HIV-1 infection. J Immunol. 1999 Apr 15; 162(8):4796-800.J Immunol1999-04-15T00:00:001999Persistent HIV-1-specific CTL clonal expansion despite high viral burden post in utero HIV-1 infection.11376327Walker BD, Korber BTNature immunologyImmune control of HIV: the obstacles of HLA and viral diversity. Nat Immunol. 2001 Jun; 2(6):473-5.Nat Immunol2001-06-01T00:00:002001Immune control of HIV: the obstacles of HLA and viral diversity.11439948Lauer GM, Walker BDThe New England journal of medicineHepatitis C virus infection. N Engl J Med. 2001 Jul 05; 345(1):41-52.N Engl J Med2001-07-05T00:00:002001Hepatitis C virus infection.12642109Severino ME, Sarkis PT, Walker BD, Yang OOVirologyChimeric immune receptor T cells bypass class I requirements and recognize multiple cell types relevant in HIV-1 infection. Virology. 2003 Feb 15; 306(2):371-5.Virology2003-02-15T00:00:002003Chimeric immune receptor T cells bypass class I requirements and recognize multiple cell types relevant in HIV-1 infection.15060434Draenert R, Brander C, Yu XG, Altfeld M, Verrill CL, Feeney ME, Walker BD, Goulder PJAIDS (London, England)Impact of intrapeptide epitope location on CD8 T cell recognition: implications for design of overlapping peptide panels. AIDS. 2004 Apr 09; 18(6):871-6.AIDS2004-04-09T00:00:002004Impact of intrapeptide epitope location on CD8 T cell recognition: implications for design of overlapping peptide panels.15781581Leslie A, Kavanagh D, Honeyborne I, Pfafferott K, Edwards C, Pillay T, Hilton L, Thobakgale C, Ramduth D, Draenert R, Le Gall S, Luzzi G, Edwards A, Brander C, Sewell AK, Moore S, Mullins J, Moore C, Mallal S, Bhardwaj N, Yusim K, Phillips R, Klenerman P, Korber B, Kiepiela P, Walker B, Goulder PThe Journal of experimental medicineTransmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA. J Exp Med. 2005 Mar 21; 201(6):891-902.J Exp Med2005-03-21T00:00:002005Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA.1372650Johnson RP, Trocha A, Buchanan TM, Walker BDThe Journal of experimental medicineIdentification of overlapping HLA class I-restricted cytotoxic T cell epitopes in a conserved region of the human immunodeficiency virus type 1 envelope glycoprotein: definition of minimum epitopes and analysis of the effects of sequence variation. J Exp Med. 1992 Apr 01; 175(4):961-71.J Exp Med1992-04-01T00:00:001992Identification of overlapping HLA class I-restricted cytotoxic T cell epitopes in a conserved region of the human immunodeficiency virus type 1 envelope glycoprotein: definition of minimum epitopes and analysis of the effects of sequence variation.10400770Kalams SA, Goulder PJ, Shea AK, Jones NG, Trocha AK, Ogg GS, Walker BDJournal of virologyLevels of human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte effector and memory responses decline after suppression of viremia with highly active antiretroviral therapy. J Virol. 1999 Aug; 73(8):6721-8.J Virol1999-08-01T00:00:001999Levels of human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte effector and memory responses decline after suppression of viremia with highly active antiretroviral therapy.10790425Lechner F, Wong DK, Dunbar PR, Chapman R, Chung RT, Dohrenwend P, Robbins G, Phillips R, Klenerman P, Walker BDThe Journal of experimental medicineAnalysis of successful immune responses in persons infected with hepatitis C virus. J Exp Med. 2000 May 01; 191(9):1499-512.J Exp Med2000-05-01T00:00:002000Analysis of successful immune responses in persons infected with hepatitis C virus.10823876Goulder PJ, Brander C, Annamalai K, Mngqundaniso N, Govender U, Tang Y, He S, Hartman KE, O'Callaghan CA, Ogg GS, Altfeld MA, Rosenberg ES, Cao H, Kalams SA, Hammond M, Bunce M, Pelton SI, Burchett SA, McIntosh K, Coovadia HM, Walker BDJournal of virologyDifferential narrow focusing of immunodominant human immunodeficiency virus gag-specific cytotoxic T-lymphocyte responses in infected African and caucasoid adults and children. J Virol. 2000 Jun; 74(12):5679-90.J Virol2000-06-01T00:00:002000Differential narrow focusing of immunodominant human immunodeficiency virus gag-specific cytotoxic T-lymphocyte responses in infected African and caucasoid adults and children.10954555Altfeld MA, Trocha A, Eldridge RL, Rosenberg ES, Phillips MN, Addo MM, Sekaly RP, Kalams SA, Burchett SA, McIntosh K, Walker BD, Goulder PJJournal of virologyIdentification of dominant optimal HLA-B60- and HLA-B61-restricted cytotoxic T-lymphocyte (CTL) epitopes: rapid characterization of CTL responses by enzyme-linked immunospot assay. J Virol. 2000 Sep; 74(18):8541-9.J Virol2000-09-01T00:00:002000Identification of dominant optimal HLA-B60- and HLA-B61-restricted cytotoxic T-lymphocyte (CTL) epitopes: rapid characterization of CTL responses by enzyme-linked immunospot assay.11005867Martinez-Picado J, DePasquale MP, Kartsonis N, Hanna GJ, Wong J, Finzi D, Rosenberg E, Gunthard HF, Sutton L, Savara A, Petropoulos CJ, Hellmann N, Walker BD, Richman DD, Siliciano R, D'Aquila RTProceedings of the National Academy of Sciences of the United States of AmericaAntiretroviral resistance during successful therapy of HIV type 1 infection. Proc Natl Acad Sci U S A. 2000 Sep 26; 97(20):10948-53.Proc Natl Acad Sci U S A2000-09-26T00:00:002000Antiretroviral resistance during successful therapy of HIV type 1 infection.11024307Cao H, Walker BDClinics in dermatologyImmunopathogenesis of HIV-1 infection. Clin Dermatol. 2000 Jul-Aug; 18(4):401-10.Clin Dermatol2000-07-01T00:00:002000Immunopathogenesis of HIV-1 infection.11160150Letvin NL, Walker BDThe Journal of clinical investigationHIV versus the immune system: another apparent victory for the virus. J Clin Invest. 2001 Feb; 107(3):273-5.J Clin Invest2001-02-01T00:00:002001HIV versus the immune system: another apparent victory for the virus.11901192Altfeld M, van Lunzen J, Frahm N, Yu XG, Schneider C, Eldridge RL, Feeney ME, Meyer-Olson D, Stellbrink HJ, Walker BDThe Journal of clinical investigationExpansion of pre-existing, lymph node-localized CD8+ T cells during supervised treatment interruptions in chronic HIV-1 infection. J Clin Invest. 2002 Mar; 109(6):837-43.J Clin Invest2002-03-01T00:00:002002Expansion of pre-existing, lymph node-localized CD8+ T cells during supervised treatment interruptions in chronic HIV-1 infection.12421812Geiben-Lynn R, Kursar M, Brown NV, Addo MM, Shau H, Lieberman J, Luster AD, Walker BDThe Journal of biological chemistryHIV-1 antiviral activity of recombinant natural killer cell enhancing factors, NKEF-A and NKEF-B, members of the peroxiredoxin family. J Biol Chem. 2003 Jan 17; 278(3):1569-74.J Biol Chem2002-11-05T00:00:002002HIV-1 antiviral activity of recombinant natural killer cell enhancing factors, NKEF-A and NKEF-B, members of the peroxiredoxin family.15265933SenGupta D, Norris PJ, Suscovich TJ, Hassan-Zahraee M, Moffett HF, Trocha A, Draenert R, Goulder PJ, Binder RJ, Levey DL, Walker BD, Srivastava PK, Brander CJournal of immunology (Baltimore, Md. : 1950)Heat shock protein-mediated cross-presentation of exogenous HIV antigen on HLA class I and class II. J Immunol. 2004 Aug 01; 173(3):1987-93.J Immunol2004-08-01T00:00:002004Heat shock protein-mediated cross-presentation of exogenous HIV antigen on HLA class I and class II.9088983Walter JB, Brander C, Mammen M, Garboczi DN, Kalams SA, Whitesides GM, Walker BD, Eisen HNInternational immunologyStimulation of human cytotoxic T cells with HIV-1-derived peptides presented by recombinant HLA-A2 peptide complexes. Int Immunol. 1997 Mar; 9(3):451-9.Int Immunol1997-03-01T00:00:001997Stimulation of human cytotoxic T cells with HIV-1-derived peptides presented by recombinant HLA-A2 peptide complexes.9328644Yang OO, Walker BDAdvances in immunologyCD8+ cells in human immunodeficiency virus type I pathogenesis: cytolytic and noncytolytic inhibition of viral replication. Adv Immunol. 1997; 66:273-311.Adv Immunol1997-01-01T00:00:001997CD8+ cells in human immunodeficiency virus type I pathogenesis: cytolytic and noncytolytic inhibition of viral replication.Authorship 96270820Authorship 9624791328182214Dominguez-Molina B, Tarancon-Diez L, Hua S, Abad-Molina C, Rodriguez-Gallego E, Machmach K, Vidal F, Tural C, Moreno S, Goñi MJ, Ramírez de Arellano E, Del Val M, Gonzalez-Escribano MF, Del Romero J, Rodriguez C, Capa L, Viciana P, Alcamí J, Yu XG, Walker BD, Leal M, Lichterfeld M, Ruiz-Mateos EClinical infectious diseases : an official publication of the Infectious Diseases Society of AmericaHLA-B*57 and IFNL4-Related Polymorphisms Are Associated With Protection Against HIV-1 Disease Progression in Controllers. Clin Infect Dis. 2017 Feb 09.Clin Infect Dis2017-02-09T00:00:002017HLA-B*57 and IFNL4-Related Polymorphisms Are Associated With Protection Against HIV-1 Disease Progression in Controllers.27253391Mahan AE, Jennewein MF, Suscovich T, Dionne K, Tedesco J, Chung AW, Streeck H, Pau M, Schuitemaker H, Francis D, Fast P, Laufer D, Walker BD, Baden L, Barouch DH, Alter GPLoS pathogensCorrection: Antigen-Specific Antibody Glycosylation Is Regulated via Vaccination. PLoS Pathog. 2016 Jun; 12(6):e1005694.PLoS Pathog2016-06-02T00:00:002016Correction: Antigen-Specific Antibody Glycosylation Is Regulated via Vaccination.10229227Finzi D, Blankson J, Siliciano JD, Margolick JB, Chadwick K, Pierson T, Smith K, Lisziewicz J, Lori F, Flexner C, Quinn TC, Chaisson RE, Rosenberg E, Walker B, Gange S, Gallant J, Siliciano RFNature medicineLatent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy. Nat Med. 1999 May; 5(5):512-7.Nat Med1999-05-01T00:00:001999Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy.10864688Severino ME, Sipsas NV, Nguyen PT, Kalams SA, Walker BD, Johnson RP, Yang OOJournal of virologyInhibition of human immunodeficiency virus type 1 replication in primary CD4(+) T lymphocytes, monocytes, and dendritic cells by cytotoxic T lymphocytes. J Virol. 2000 Jul; 74(14):6695-9.J Virol2000-07-01T00:00:002000Inhibition of human immunodeficiency virus type 1 replication in primary CD4(+) T lymphocytes, monocytes, and dendritic cells by cytotoxic T lymphocytes.11148222Goulder PJ, Altfeld MA, Rosenberg ES, Nguyen T, Tang Y, Eldridge RL, Addo MM, He S, Mukherjee JS, Phillips MN, Bunce M, Kalams SA, Sekaly RP, Walker BD, Brander CThe Journal of experimental medicineSubstantial differences in specificity of HIV-specific cytotoxic T cells in acute and chronic HIV infection. J Exp Med. 2001 Jan 15; 193(2):181-94.J Exp Med2001-01-15T00:00:002001Substantial differences in specificity of HIV-specific cytotoxic T cells in acute and chronic HIV infection.10233917Yang OO, Swanberg SL, Lu Z, Dziejman M, McCoy J, Luster AD, Walker BD, Herrmann SHJournal of virologyEnhanced inhibition of human immunodeficiency virus type 1 by Met-stromal-derived factor 1beta correlates with down-modulation of CXCR4. J Virol. 1999 Jun; 73(6):4582-9.J Virol1999-06-01T00:00:001999Enhanced inhibition of human immunodeficiency virus type 1 by Met-stromal-derived factor 1beta correlates with down-modulation of CXCR4.10559335Brander C, Yang OO, Jones NG, Lee Y, Goulder P, Johnson RP, Trocha A, Colbert D, Hay C, Buchbinder S, Bergmann CC, Zweerink HJ, Wolinsky S, Blattner WA, Kalams SA, Walker BDJournal of virologyEfficient processing of the immunodominant, HLA-A*0201-restricted human immunodeficiency virus type 1 cytotoxic T-lymphocyte epitope despite multiple variations in the epitope flanking sequences. J Virol. 1999 Dec; 73(12):10191-8.J Virol1999-12-01T00:00:001999Efficient processing of the immunodominant, HLA-A*0201-restricted human immunodeficiency virus type 1 cytotoxic T-lymphocyte epitope despite multiple variations in the epitope flanking sequences.16533886Draenert R, Allen TM, Liu Y, Wrin T, Chappey C, Verrill CL, Sirera G, Eldridge RL, Lahaie MP, Ruiz L, Clotet B, Petropoulos CJ, Walker BD, Martinez-Picado JThe Journal of experimental medicineConstraints on HIV-1 evolution and immunodominance revealed in monozygotic adult twins infected with the same virus. J Exp Med. 2006 Mar 20; 203(3):529-39.J Exp Med2006-03-13T00:00:002006Constraints on HIV-1 evolution and immunodominance revealed in monozygotic adult twins infected with the same virus.17187074Fischer W, Perkins S, Theiler J, Bhattacharya T, Yusim K, Funkhouser R, Kuiken C, Haynes B, Letvin NL, Walker BD, Hahn BH, Korber BTNature medicinePolyvalent vaccines for optimal coverage of potential T-cell epitopes in global HIV-1 variants. Nat Med. 2007 Jan; 13(1):100-6.Nat Med2006-12-24T00:00:002006Polyvalent vaccines for optimal coverage of potential T-cell epitopes in global HIV-1 variants.9672231Rosenberg ES, Walker BDAIDS research and human retrovirusesHIV type 1-specific helper T cells: a critical host defense. AIDS Res Hum Retroviruses. 1998 Jun; 14 Suppl 2:S143-7.AIDS Res Hum Retroviruses1998-06-01T00:00:001998HIV type 1-specific helper T cells: a critical host defense.11462197Walensky RP, Rosenberg ES, Ferraro MJ, Losina E, Walker BD, Freedberg KAClinical infectious diseases : an official publication of the Infectious Diseases Society of AmericaInvestigation of primary human immunodeficiency virus infection in patients who test positive for heterophile antibody. Clin Infect Dis. 2001 Aug 15; 33(4):570-2.Clin Infect Dis2001-07-20T00:00:002001Investigation of primary human immunodeficiency virus infection in patients who test positive for heterophile antibody.11509618Altfeld M, Addo MM, Eldridge RL, Yu XG, Thomas S, Khatri A, Strick D, Phillips MN, Cohen GB, Islam SA, Kalams SA, Brander C, Goulder PJ, Rosenberg ES, Walker BDJournal of immunology (Baltimore, Md. : 1950)Vpr is preferentially targeted by CTL during HIV-1 infection. J Immunol. 2001 Sep 01; 167(5):2743-52.J Immunol2001-09-01T00:00:002001Vpr is preferentially targeted by CTL during HIV-1 infection.17728232Brockman MA, Schneidewind A, Lahaie M, Schmidt A, Miura T, Desouza I, Ryvkin F, Derdeyn CA, Allen S, Hunter E, Mulenga J, Goepfert PA, Walker BD, Allen TMJournal of virologyEscape and compensation from early HLA-B57-mediated cytotoxic T-lymphocyte pressure on human immunodeficiency virus type 1 Gag alter capsid interactions with cyclophilin A. J Virol. 2007 Nov; 81(22):12608-18.J Virol2007-08-29T00:00:002007Escape and compensation from early HLA-B57-mediated cytotoxic T-lymphocyte pressure on human immunodeficiency virus type 1 Gag alter capsid interactions with cyclophilin A.18467582Walker BD, Burton DRScience (New York, N.Y.)Toward an AIDS vaccine. Science. 2008 May 09; 320(5877):760-4.Science2008-05-09T00:00:002008Toward an AIDS vaccine.19023406Carlson JM, Brumme ZL, Rousseau CM, Brumme CJ, Matthews P, Kadie C, Mullins JI, Walker BD, Harrigan PR, Goulder PJ, Heckerman DPLoS computational biologyPhylogenetic dependency networks: inferring patterns of CTL escape and codon covariation in HIV-1 Gag. PLoS Comput Biol. 2008 Nov; 4(11):e1000225.PLoS Comput Biol2008-11-21T00:00:002008Phylogenetic dependency networks: inferring patterns of CTL escape and codon covariation in HIV-1 Gag.19244334Matthews PC, Leslie AJ, Katzourakis A, Crawford H, Payne R, Prendergast A, Power K, Kelleher AD, Klenerman P, Carlson J, Heckerman D, Ndung'u T, Walker BD, Allen TM, Pybus OG, Goulder PJJournal of virologyHLA footprints on human immunodeficiency virus type 1 are associated with interclade polymorphisms and intraclade phylogenetic clustering. J Virol. 2009 May; 83(9):4605-15.J Virol2009-02-25T00:00:002009HLA footprints on human immunodeficiency virus type 1 are associated with interclade polymorphisms and intraclade phylogenetic clustering.19553339Liu Q, Sun Y, Rihn S, Nolting A, Tsoukas PN, Jost S, Cohen K, Walker B, Alter GJournal of virologyMatrix metalloprotease inhibitors restore impaired NK cell-mediated antibody-dependent cellular cytotoxicity in human immunodeficiency virus type 1 infection. J Virol. 2009 Sep; 83(17):8705-12.J Virol2009-06-24T00:00:002009Matrix metalloprotease inhibitors restore impaired NK cell-mediated antibody-dependent cellular cytotoxicity in human immunodeficiency virus type 1 infection.11413294Day CL, Shea AK, Altfeld MA, Olson DP, Buchbinder SP, Hecht FM, Rosenberg ES, Walker BD, Kalams SAJournal of virologyRelative dominance of epitope-specific cytotoxic T-lymphocyte responses in human immunodeficiency virus type 1-infected persons with shared HLA alleles. J Virol. 2001 Jul; 75(14):6279-91.J Virol2001-07-01T00:00:002001Relative dominance of epitope-specific cytotoxic T-lymphocyte responses in human immunodeficiency virus type 1-infected persons with shared HLA alleles.11799157Yang OO, Nguyen PT, Kalams SA, Dorfman T, Göttlinger HG, Stewart S, Chen IS, Threlkeld S, Walker BDJournal of virologyNef-mediated resistance of human immunodeficiency virus type 1 to antiviral cytotoxic T lymphocytes. J Virol. 2002 Feb; 76(4):1626-31.J Virol2002-02-01T00:00:002002Nef-mediated resistance of human immunodeficiency virus type 1 to antiviral cytotoxic T lymphocytes.12776210Autran B, Debré P, Walker B, Katlama CNature reviews. ImmunologyTherapeutic vaccines against HIV need international partnerships. Nat Rev Immunol. 2003 Jun; 3(6):503-8.Nat Rev Immunol2003-06-01T00:00:002003Therapeutic vaccines against HIV need international partnerships.14500671Yang OO, Sarkis PT, Trocha A, Kalams SA, Johnson RP, Walker BDJournal of immunology (Baltimore, Md. : 1950)Impacts of avidity and specificity on the antiviral efficiency of HIV-1-specific CTL. J Immunol. 2003 Oct 01; 171(7):3718-24.J Immunol2003-10-01T00:00:002003Impacts of avidity and specificity on the antiviral efficiency of HIV-1-specific CTL.15381726Lichterfeld M, Kaufmann DE, Yu XG, Mui SK, Addo MM, Johnston MN, Cohen D, Robbins GK, Pae E, Alter G, Wurcel A, Stone D, Rosenberg ES, Walker BD, Altfeld MThe Journal of experimental medicineLoss of HIV-1-specific CD8+ T cell proliferation after acute HIV-1 infection and restoration by vaccine-induced HIV-1-specific CD4+ T cells. J Exp Med. 2004 Sep 20; 200(6):701-12.J Exp Med2004-09-20T00:00:002004Loss of HIV-1-specific CD8+ T cell proliferation after acute HIV-1 infection and restoration by vaccine-induced HIV-1-specific CD4+ T cells.15526059Kaufmann DE, Lichterfeld M, Altfeld M, Addo MM, Johnston MN, Lee PK, Wagner BS, Kalife ET, Strick D, Rosenberg ES, Walker BDPLoS medicineLimited durability of viral control following treated acute HIV infection. PLoS Med. 2004 Nov; 1(2):e36.PLoS Med2004-10-26T00:00:002004Limited durability of viral control following treated acute HIV infection.15685300Walker BD, Krahn AD, Klein GJ, Skanes AC, Yee R, Wang J, Hegele RAThe Canadian journal of cardiologyEffect of change in posture and exercise on repolarization in patients with long QT syndrome with HERG channel mutations. Can J Cardiol. 2005 Jan; 21(1):33-8.Can J Cardiol2005-01-01T00:00:002005Effect of change in posture and exercise on repolarization in patients with long QT syndrome with HERG channel mutations.10400769Kalams SA, Buchbinder SP, Rosenberg ES, Billingsley JM, Colbert DS, Jones NG, Shea AK, Trocha AK, Walker BDJournal of virologyAssociation between virus-specific cytotoxic T-lymphocyte and helper responses in human immunodeficiency virus type 1 infection. J Virol. 1999 Aug; 73(8):6715-20.J Virol1999-08-01T00:00:001999Association between virus-specific cytotoxic T-lymphocyte and helper responses in human immunodeficiency virus type 1 infection.10545982Goulder PJ, Walker BDNature medicineThe great escape - AIDS viruses and immune control. Nat Med. 1999 Nov; 5(11):1233-5.Nat Med1999-11-01T00:00:001999The great escape - AIDS viruses and immune control.10756051Alexander L, Weiskopf E, Greenough TC, Gaddis NC, Auerbach MR, Malim MH, O'Brien SJ, Walker BD, Sullivan JL, Desrosiers RCJournal of virologyUnusual polymorphisms in human immunodeficiency virus type 1 associated with nonprogressive infection. J Virol. 2000 May; 74(9):4361-76.J Virol2000-05-01T00:00:002000Unusual polymorphisms in human immunodeficiency virus type 1 associated with nonprogressive infection.11023458Cao H, Mani I, Vincent R, Mugerwa R, Mugyenyi P, Kanki P, Ellner J, Walker BDThe Journal of infectious diseasesCellular immunity to human immunodeficiency virus type 1 (HIV-1) clades: relevance to HIV-1 vaccine trials in Uganda. J Infect Dis. 2000 Nov; 182(5):1350-6.J Infect Dis2000-10-09T00:00:002000Cellular immunity to human immunodeficiency virus type 1 (HIV-1) clades: relevance to HIV-1 vaccine trials in Uganda.11930329Yang OO, Garcia-Zepeda EA, Walker BD, Luster ADThe Journal of infectious diseasesMonocyte chemoattractant protein-2 (CC chemokine ligand 8) inhibits replication of human immunodeficiency virus type 1 via CC chemokine receptor 5. J Infect Dis. 2002 Apr 15; 185(8):1174-8.J Infect Dis2002-04-01T00:00:002002Monocyte chemoattractant protein-2 (CC chemokine ligand 8) inhibits replication of human immunodeficiency virus type 1 via CC chemokine receptor 5.14676292Day CL, Walker BDThe Journal of experimental medicineProgress in defining CD4 helper cell responses in chronic viral infections. J Exp Med. 2003 Dec 15; 198(12):1773-7.J Exp Med2003-12-15T00:00:002003Progress in defining CD4 helper cell responses in chronic viral infections.14734757Lucas M, Vargas-Cuero AL, Lauer GM, Barnes E, Willberg CB, Semmo N, Walker BD, Phillips R, Klenerman PJournal of immunology (Baltimore, Md. : 1950)Pervasive influence of hepatitis C virus on the phenotype of antiviral CD8+ T cells. J Immunol. 2004 Feb 01; 172(3):1744-53.J Immunol2004-02-01T00:00:002004Pervasive influence of hepatitis C virus on the phenotype of antiviral CD8+ T cells.17251285Honeyborne I, Prendergast A, Pereyra F, Leslie A, Crawford H, Payne R, Reddy S, Bishop K, Moodley E, Nair K, van der Stok M, McCarthy N, Rousseau CM, Addo M, Mullins JI, Brander C, Kiepiela P, Walker BD, Goulder PJJournal of virologyControl of human immunodeficiency virus type 1 is associated with HLA-B*13 and targeting of multiple gag-specific CD8+ T-cell epitopes. 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J Virol. 2007 Jul; 81(14):7725-31.J Virol2007-05-09T00:00:002007Recognition of a defined region within p24 gag by CD8+ T cells during primary human immunodeficiency virus type 1 infection in individuals expressing protective HLA class I alleles.17388662Gasser O, Bihl FK, Wolbers M, Loggi E, Steffen I, Hirsch HH, Günthard HF, Walker BD, Brander C, Battegay M, Hess CPLoS medicineHIV patients developing primary CNS lymphoma lack EBV-specific CD4+ T cell function irrespective of absolute CD4+ T cell counts. PLoS Med. 2007 Mar 27; 4(3):e96.PLoS Med2007-03-27T00:00:002007HIV patients developing primary CNS lymphoma lack EBV-specific CD4+ T cell function irrespective of absolute CD4+ T cell counts.17786195Rolland M, Nickle DC, Deng W, Frahm N, Brander C, Learn GH, Heckerman D, Jojic N, Jojic V, Walker BD, Mullins JIPloS oneRecognition of HIV-1 peptides by host CTL is related to HIV-1 similarity to human proteins. PLoS One. 2007 Sep 05; 2(9):e823.PLoS One2007-09-05T00:00:002007Recognition of HIV-1 peptides by host CTL is related to HIV-1 similarity to human proteins.17720999Walker BDTopics in HIV medicine : a publication of the International AIDS Society, USAElite control of HIV Infection: implications for vaccines and treatment. Top HIV Med. 2007 Aug-Sep; 15(4):134-6.Top HIV Med2007-08-01T00:00:002007Elite control of HIV Infection: implications for vaccines and treatment.18580613Prendergast A, Mphatswe W, Tudor-Williams G, Rakgotho M, Pillay V, Thobakgale C, McCarthy N, Morris L, Walker BD, Goulder PAIDS (London, England)Early virological suppression with three-class antiretroviral therapy in HIV-infected African infants. AIDS. 2008 Jul 11; 22(11):1333-43.AIDS2008-07-11T00:00:002008Early virological suppression with three-class antiretroviral therapy in HIV-infected African infants.14963115Frahm N, Korber BT, Adams CM, Szinger JJ, Draenert R, Addo MM, Feeney ME, Yusim K, Sango K, Brown NV, SenGupta D, Piechocka-Trocha A, Simonis T, Marincola FM, Wurcel AG, Stone DR, Russell CJ, Adolf P, Cohen D, Roach T, StJohn A, Khatri A, Davis K, Mullins J, Goulder PJ, Walker BD, Brander CJournal of virologyConsistent cytotoxic-T-lymphocyte targeting of immunodominant regions in human immunodeficiency virus across multiple ethnicities. J Virol. 2004 Mar; 78(5):2187-200.J Virol2004-03-01T00:00:002004Consistent cytotoxic-T-lymphocyte targeting of immunodominant regions in human immunodeficiency virus across multiple ethnicities.15292066Hess C, Means TK, Autissier P, Woodberry T, Altfeld M, Addo MM, Frahm N, Brander C, Walker BD, Luster ADBloodIL-8 responsiveness defines a subset of CD8 T cells poised to kill. Blood. 2004 Dec 01; 104(12):3463-71.Blood2004-08-03T00:00:002004IL-8 responsiveness defines a subset of CD8 T cells poised to kill.28628034Lee GQ, Orlova-Fink N, Einkauf K, Chowdhury FZ, Sun X, Harrington S, Kuo HH, Hua S, Chen HR, Ouyang Z, Reddy K, Dong K, Ndung'u T, Walker BD, Rosenberg ES, Yu XG, Lichterfeld MThe Journal of clinical investigationClonal expansion of genome-intact HIV-1 in functionally polarized Th1 CD4+ T cells. J Clin Invest. 2017 Jun 30; 127(7):2689-2696.J Clin Invest2017-06-19T00:00:002017Clonal expansion of genome-intact HIV-1 in functionally polarized Th1 CD4+ T cells.15280502Feeney ME, Tang Y, Roosevelt KA, Leslie AJ, McIntosh K, Karthas N, Walker BD, Goulder PJJournal of virologyImmune escape precedes breakthrough human immunodeficiency virus type 1 viremia and broadening of the cytotoxic T-lymphocyte response in an HLA-B27-positive long-term-nonprogressing child. J Virol. 2004 Aug; 78(16):8927-30.J Virol2004-08-01T00:00:002004Immune escape precedes breakthrough human immunodeficiency virus type 1 viremia and broadening of the cytotoxic T-lymphocyte response in an HLA-B27-positive long-term-nonprogressing child.18183304Rolland M, Heckerman D, Deng W, Rousseau CM, Coovadia H, Bishop K, Goulder PJ, Walker BD, Brander C, Mullins JIPloS oneBroad and Gag-biased HIV-1 epitope repertoires are associated with lower viral loads. PLoS One. 2008 Jan 09; 3(1):e1424.PLoS One2008-01-09T00:00:002008Broad and Gag-biased HIV-1 epitope repertoires are associated with lower viral loads.10448136Brander C, Walker BDCurrent opinion in immunologyT lymphocyte responses in HIV-1 infection: implications for vaccine development. Curr Opin Immunol. 1999 Aug; 11(4):451-9.Curr Opin Immunol1999-08-01T00:00:001999T lymphocyte responses in HIV-1 infection: implications for vaccine development.10982373Le Gall S, Buseyne F, Trocha A, Walker BD, Heard JM, Schwartz OJournal of virologyDistinct trafficking pathways mediate Nef-induced and clathrin-dependent major histocompatibility complex class I down-regulation. J Virol. 2000 Oct; 74(19):9256-66.J Virol2000-10-01T00:00:002000Distinct trafficking pathways mediate Nef-induced and clathrin-dependent major histocompatibility complex class I down-regulation.11120778Goulder PJ, Tang Y, Brander C, Betts MR, Altfeld M, Annamalai K, Trocha A, He S, Rosenberg ES, Ogg G, O'Callaghan CA, Kalams SA, McKinney RE, Mayer K, Koup RA, Pelton SI, Burchett SK, McIntosh K, Walker BDThe Journal of experimental medicineFunctionally inert HIV-specific cytotoxic T lymphocytes do not play a major role in chronically infected adults and children. J Exp Med. 2000 Dec 18; 192(12):1819-32.J Exp Med2000-12-18T00:00:002000Functionally inert HIV-specific cytotoxic T lymphocytes do not play a major role in chronically infected adults and children.Authorship 9915081411334960Brander C, Matter-Reissmann UB, Jones NG, Walker BD, Sachs DH, Seebach JDJournal of immunological methodsInhibition of human NK cell-mediated cytotoxicity by exposure to ammonium chloride. J Immunol Methods. 2001 Jun 01; 252(1-2):1-14.J Immunol Methods2001-06-01T00:00:002001Inhibition of human NK cell-mediated cytotoxicity by exposure to ammonium chloride.19153230Miura T, Brumme CJ, Brockman MA, Brumme ZL, Pereyra F, Block BL, Trocha A, John M, Mallal S, Harrigan PR, Walker BDJournal of virologyHLA-associated viral mutations are common in human immunodeficiency virus type 1 elite controllers. J Virol. 2009 Apr; 83(7):3407-12.J Virol2009-01-19T00:00:002009HLA-associated viral mutations are common in human immunodeficiency virus type 1 elite controllers.18596105Matthews PC, Prendergast A, Leslie A, Crawford H, Payne R, Rousseau C, Rolland M, Honeyborne I, Carlson J, Kadie C, Brander C, Bishop K, Mlotshwa N, Mullins JI, Coovadia H, Ndung'u T, Walker BD, Heckerman D, Goulder PJJournal of virologyCentral role of reverting mutations in HLA associations with human immunodeficiency virus set point. J Virol. 2008 Sep; 82(17):8548-59.J Virol2008-07-02T00:00:002008Central role of reverting mutations in HLA associations with human immunodeficiency virus set point.12396610Addo MM, Yu XG, Rosenberg ES, Walker BD, Altfeld MDNA and cell biologyCytotoxic T-lymphocyte (CTL) responses directed against regulatory and accessory proteins in HIV-1 infection. DNA Cell Biol. 2002 Sep; 21(9):671-8.DNA Cell Biol2002-09-01T00:00:002002Cytotoxic T-lymphocyte (CTL) responses directed against regulatory and accessory proteins in HIV-1 infection.12805431Altfeld M, Addo MM, Shankarappa R, Lee PK, Allen TM, Yu XG, Rathod A, Harlow J, O'Sullivan K, Johnston MN, Goulder PJ, Mullins JI, Rosenberg ES, Brander C, Korber B, Walker BDJournal of virologyEnhanced detection of human immunodeficiency virus type 1-specific T-cell responses to highly variable regions by using peptides based on autologous virus sequences. J Virol. 2003 Jul; 77(13):7330-40.J Virol2003-07-01T00:00:002003Enhanced detection of human immunodeficiency virus type 1-specific T-cell responses to highly variable regions by using peptides based on autologous virus sequences.19420076Brainard DM, Seung E, Frahm N, Cariappa A, Bailey CC, Hart WK, Shin HS, Brooks SF, Knight HL, Eichbaum Q, Yang YG, Sykes M, Walker BD, Freeman GJ, Pillai S, Westmoreland SV, Brander C, Luster AD, Tager AMJournal of virologyInduction of robust cellular and humoral virus-specific adaptive immune responses in human immunodeficiency virus-infected humanized BLT mice. J Virol. 2009 Jul; 83(14):7305-21.J Virol2009-05-06T00:00:002009Induction of robust cellular and humoral virus-specific adaptive immune responses in human immunodeficiency virus-infected humanized BLT mice.19454339Walley NM, Julg B, Dickson SP, Fellay J, Ge D, Walker BD, Carrington M, Cohen MS, de Bakker PI, Goldstein DB, Shianna KV, Haynes BF, Letvin NL, McMichael AJ, Michael NL, Weintrob ACCell host & microbeThe Duffy antigen receptor for chemokines null promoter variant does not influence HIV-1 acquisition or disease progression. Cell Host Microbe. 2009 May 08; 5(5):408-10; author reply 418-9.Cell Host Microbe2009-05-08T00:00:002009The Duffy antigen receptor for chemokines null promoter variant does not influence HIV-1 acquisition or disease progression.19487418Brumme ZL, Walker BDThe Journal of experimental medicineTracking the culprit: HIV-1 evolution and immune selection revealed by single-genome amplification. J Exp Med. 2009 Jun 08; 206(6):1215-8.J Exp Med2009-06-01T00:00:002009Tracking the culprit: HIV-1 evolution and immune selection revealed by single-genome amplification.19505257Lazaro E, Godfrey SB, Stamegna P, Ogbechie T, Kerrigan C, Zhang M, Walker BD, Le Gall SThe Journal of infectious diseasesDifferential HIV epitope processing in monocytes and CD4 T cells affects cytotoxic T lymphocyte recognition. J Infect Dis. 2009 Jul 15; 200(2):236-43.J Infect Dis2009-07-15T00:00:002009Differential HIV epitope processing in monocytes and CD4 T cells affects cytotoxic T lymphocyte recognition.Aldovini A, Walker BD, editors.Techniques in HIV Research. 1990.1990-01-01T00:00:001990Techniques in HIV Research12975468Day CL, Seth NP, Lucas M, Appel H, Gauthier L, Lauer GM, Robbins GK, Szczepiorkowski ZM, Casson DR, Chung RT, Bell S, Harcourt G, Walker BD, Klenerman P, Wucherpfennig KWThe Journal of clinical investigationEx vivo analysis of human memory CD4 T cells specific for hepatitis C virus using MHC class II tetramers. J Clin Invest. 2003 Sep; 112(6):831-42.J Clin Invest2003-09-01T00:00:002003Ex vivo analysis of human memory CD4 T cells specific for hepatitis C virus using MHC class II tetramers.1845771Goldfeld AE, Birch-Limberger K, Schooley RT, Walker BDJournal of acquired immune deficiency syndromesHIV-1 infection does not induce tumor necrosis factor-alpha or interferon-beta gene transcription. J Acquir Immune Defic Syndr (1988). 1991; 4(1):41-7.J Acquir Immune Defic Syndr (1988)1991-01-01T00:00:001991HIV-1 infection does not induce tumor necrosis factor-alpha or interferon-beta gene transcription.15795285Altfeld M, Allen TM, Kalife ET, Frahm N, Addo MM, Mothe BR, Rathod A, Reyor LL, Harlow J, Yu XG, Perkins B, Robinson LK, Sidney J, Alter G, Lichterfeld M, Sette A, Rosenberg ES, Goulder PJ, Brander C, Walker BDJournal of virologyThe majority of currently circulating human immunodeficiency virus type 1 clade B viruses fail to prime cytotoxic T-lymphocyte responses against an otherwise immunodominant HLA-A2-restricted epitope: implications for vaccine design. J Virol. 2005 Apr; 79(8):5000-5.J Virol2005-04-01T00:00:002005The majority of currently circulating human immunodeficiency virus type 1 clade B viruses fail to prime cytotoxic T-lymphocyte responses against an otherwise immunodominant HLA-A2-restricted epitope: implications for vaccine design.16189000Lauer GM, Lucas M, Timm J, Ouchi K, Kim AY, Day CL, Schulze Zur Wiesch J, Paranhos-Baccala G, Sheridan I, Casson DR, Reiser M, Gandhi RT, Li B, Allen TM, Chung RT, Klenerman P, Walker BDJournal of virologyFull-breadth analysis of CD8+ T-cell responses in acute hepatitis C virus infection and early therapy. J Virol. 2005 Oct; 79(20):12979-88.J Virol2005-10-01T00:00:002005Full-breadth analysis of CD8+ T-cell responses in acute hepatitis C virus infection and early therapy.Authorship 996053728692209Beyrer C, Shisana O, Baral SD, Milsana K, Mayer KH, Pozniak A, Walker BD, Mboup S, Sohn AH, Serwadda D, Rees H, Dvoriak S, Warren M, Thiam S, El-Sadr WM, Hospital X, Ryan O, Thomson N, Bekker LGJournal of the International AIDS SocietyThe science of Durban, AIDS 2016. J Int AIDS Soc. 2017 06 30; 20(1):21781.J Int AIDS Soc2017-06-30T00:00:002017The science of Durban, AIDS 2016.7532426Harrer E, Harrer T, Buchbinder S, Mann DL, Feinberg M, Yilma T, Johnson RP, Walker BDAIDS research and human retrovirusesHIV-1-specific cytotoxic T lymphocyte response in healthy, long-term nonprogressing seropositive persons. AIDS Res Hum Retroviruses. 1994; 10 Suppl 2:S77-8.AIDS Res Hum Retroviruses1994-01-01T00:00:001994HIV-1-specific cytotoxic T lymphocyte response in healthy, long-term nonprogressing seropositive persons.7682629Jassoy C, Harrer T, Rosenthal T, Navia BA, Worth J, Johnson RP, Walker BDJournal of virologyHuman immunodeficiency virus type 1-specific cytotoxic T lymphocytes release gamma interferon, tumor necrosis factor alpha (TNF-alpha), and TNF-beta when they encounter their target antigens. J Virol. 1993 May; 67(5):2844-52.J Virol1993-05-01T00:00:001993Human immunodeficiency virus type 1-specific cytotoxic T lymphocytes release gamma interferon, tumor necrosis factor alpha (TNF-alpha), and TNF-beta when they encounter their target antigens.7693974Koziel MJ, Dudley D, Afdhal N, Choo QL, Houghton M, Ralston R, Walker BDJournal of virologyHepatitis C virus (HCV)-specific cytotoxic T lymphocytes recognize epitopes in the core and envelope proteins of HCV. J Virol. 1993 Dec; 67(12):7522-32.J Virol1993-12-01T00:00:001993Hepatitis C virus (HCV)-specific cytotoxic T lymphocytes recognize epitopes in the core and envelope proteins of HCV.8145043Kalams SA, Johnson RP, Trocha AK, Dynan MJ, Ngo HS, D'Aquila RT, Kurnick JT, Walker BDThe Journal of experimental medicineLongitudinal analysis of T cell receptor (TCR) gene usage by human immunodeficiency virus 1 envelope-specific cytotoxic T lymphocyte clones reveals a limited TCR repertoire. J Exp Med. 1994 Apr 01; 179(4):1261-71.J Exp Med1994-04-01T00:00:001994Longitudinal analysis of T cell receptor (TCR) gene usage by human immunodeficiency virus 1 envelope-specific cytotoxic T lymphocyte clones reveals a limited TCR repertoire.17616974Brumme ZL, Brumme CJ, Heckerman D, Korber BT, Daniels M, Carlson J, Kadie C, Bhattacharya T, Chui C, Szinger J, Mo T, Hogg RS, Montaner JS, Frahm N, Brander C, Walker BD, Harrigan PRPLoS pathogensEvidence of differential HLA class I-mediated viral evolution in functional and accessory/regulatory genes of HIV-1. PLoS Pathog. 2007 Jul; 3(7):e94.PLoS Pathog2007-07-01T00:00:002007Evidence of differential HLA class I-mediated viral evolution in functional and accessory/regulatory genes of HIV-1.18562530Miura T, Brockman MA, Brumme CJ, Brumme ZL, Carlson JM, Pereyra F, Trocha A, Addo MM, Block BL, Rothchild AC, Baker BM, Flynn T, Schneidewind A, Li B, Wang YE, Heckerman D, Allen TM, Walker BDJournal of virologyGenetic characterization of human immunodeficiency virus type 1 in elite controllers: lack of gross genetic defects or common amino acid changes. J Virol. 2008 Sep; 82(17):8422-30.J Virol2008-06-18T00:00:002008Genetic characterization of human immunodeficiency virus type 1 in elite controllers: lack of gross genetic defects or common amino acid changes.19414738Kaufmann DE, Walker BDJournal of immunology (Baltimore, Md. : 1950)PD-1 and CTLA-4 inhibitory cosignaling pathways in HIV infection and the potential for therapeutic intervention. J Immunol. 2009 May 15; 182(10):5891-7.J Immunol2009-05-15T00:00:002009PD-1 and CTLA-4 inhibitory cosignaling pathways in HIV infection and the potential for therapeutic intervention.19454341Julg B, Reddy S, van der Stok M, Kulkarni S, Qi Y, Bass S, Gold B, Nalls MA, Nelson GW, Walker BD, Carrington M, Ndung'u TCell host & microbeLack of Duffy antigen receptor for chemokines: no influence on HIV disease progression in an African treatment-naive population. Cell Host Microbe. 2009 May 08; 5(5):413-5; author reply 418-9.Cell Host Microbe2009-05-08T00:00:002009Lack of Duffy antigen receptor for chemokines: no influence on HIV disease progression in an African treatment-naive population.7532425Johnson RP, Hammond SA, Trocha A, Siliciano RF, Walker BDAIDS research and human retrovirusesEpitope specificity of MHC restricted cytotoxic T lymphocytes induced by candidate HIV-1 vaccine. AIDS Res Hum Retroviruses. 1994; 10 Suppl 2:S73-5.AIDS Res Hum Retroviruses1994-01-01T00:00:001994Epitope specificity of MHC restricted cytotoxic T lymphocytes induced by candidate HIV-1 vaccine.7924192Kalams SA, Walker BDClinics in laboratory medicineThe cytotoxic T-lymphocyte response in HIV-1 infection. Clin Lab Med. 1994 Jun; 14(2):271-99.Clin Lab Med1994-06-01T00:00:001994The cytotoxic T-lymphocyte response in HIV-1 infection.16436130Komatsu H, Lauer G, Pybus OG, Ouchi K, Wong D, Ward S, Walker B, Klenerman PJournal of viral hepatitisDo antiviral CD8+ T cells select hepatitis C virus escape mutants? Analysis in diverse epitopes targeted by human intrahepatic CD8+ T lymphocytes. J Viral Hepat. 2006 Feb; 13(2):121-30.J Viral Hepat2006-02-01T00:00:002006Do antiviral CD8+ T cells select hepatitis C virus escape mutants? Analysis in diverse epitopes targeted by human intrahepatic CD8+ T lymphocytes.9257824Threlkeld SC, Wentworth PA, Kalams SA, Wilkes BM, Ruhl DJ, Keogh E, Sidney J, Southwood S, Walker BD, Sette AJournal of immunology (Baltimore, Md. : 1950)Degenerate and promiscuous recognition by CTL of peptides presented by the MHC class I A3-like superfamily: implications for vaccine development. J Immunol. 1997 Aug 15; 159(4):1648-57.J Immunol1997-08-15T00:00:001997Degenerate and promiscuous recognition by CTL of peptides presented by the MHC class I A3-like superfamily: implications for vaccine development.21844303Radebe M, Nair K, Chonco F, Bishop K, Wright JK, van der Stok M, Bassett IV, Mncube Z, Altfeld M, Walker BD, Ndung'u TThe Journal of infectious diseasesLimited immunogenicity of HIV CD8+ T-cell epitopes in acute Clade C virus infection. J Infect Dis. 2011 Sep 01; 204(5):768-76.J Infect Dis2011-09-01T00:00:002011Limited immunogenicity of HIV CD8+ T-cell epitopes in acute Clade C virus infection.22761379Stephenson KE, Li H, Walker BD, Michael NL, Barouch DHJournal of virologyGag-specific cellular immunity determines in vitro viral inhibition and in vivo virologic control following simian immunodeficiency virus challenges of vaccinated rhesus monkeys. J Virol. 2012 Sep; 86(18):9583-9.J Virol2012-07-03T00:00:002012Gag-specific cellular immunity determines in vitro viral inhibition and in vivo virologic control following simian immunodeficiency virus challenges of vaccinated rhesus monkeys.17906628Kaufmann DE, Kavanagh DG, Pereyra F, Zaunders JJ, Mackey EW, Miura T, Palmer S, Brockman M, Rathod A, Piechocka-Trocha A, Baker B, Zhu B, Le Gall S, Waring MT, Ahern R, Moss K, Kelleher AD, Coffin JM, Freeman GJ, Rosenberg ES, Walker BDNature immunologyUpregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction. Nat Immunol. 2007 Nov; 8(11):1246-54.Nat Immunol2007-09-30T00:00:002007Upregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction.19372991Kaufmann DE, Walker BDCurrent opinion in HIV and AIDSProgrammed death-1 as a factor in immune exhaustion and activation in HIV infection. Curr Opin HIV AIDS. 2008 May; 3(3):362-7.Curr Opin HIV AIDS2008-05-01T00:00:002008Programmed death-1 as a factor in immune exhaustion and activation in HIV infection.19498149Murphy RL, Autran B, Katlama C, Brucker G, Debre P, Calvez V, Clotet B, Clumeck N, Costagliola D, Deeks SG, Dorrell L, Gatell J, Haase A, Klein M, Lazzarin A, McMichael AJ, Papagno L, Schacker TW, Wain-Hobson S, Walker BD, Youle MScience (New York, N.Y.)A step ahead on the HIV collaboratory. Science. 2009 Jun 05; 324(5932):1264-5.Science2009-06-05T00:00:002009A step ahead on the HIV collaboratory.19935663Thomas R, Apps R, Qi Y, Gao X, Male V, O'hUigin C, O'Connor G, Ge D, Fellay J, Martin JN, Margolick J, Goedert JJ, Buchbinder S, Kirk GD, Martin MP, Telenti A, Deeks SG, Walker BD, Goldstein D, McVicar DW, Moffett A, Carrington MNature geneticsHLA-C cell surface expression and control of HIV/AIDS correlate with a variant upstream of HLA-C. Nat Genet. 2009 Dec; 41(12):1290-4.Nat Genet2009-12-01T00:00:002009HLA-C cell surface expression and control of HIV/AIDS correlate with a variant upstream of HLA-C.21764753Scheid JF, Mouquet H, Ueberheide B, Diskin R, Klein F, Oliveira TY, Pietzsch J, Fenyo D, Abadir A, Velinzon K, Hurley A, Myung S, Boulad F, Poignard P, Burton DR, Pereyra F, Ho DD, Walker BD, Seaman MS, Bjorkman PJ, Chait BT, Nussenzweig MCScience (New York, N.Y.)Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding. Science. 2011 Sep 16; 333(6049):1633-7.Science2011-07-14T00:00:002011Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding.22514340Ndhlovu ZM, Proudfoot J, Cesa K, Alvino DM, McMullen A, Vine S, Stampouloglou E, Piechocka-Trocha A, Walker BD, Pereyra FJournal of virologyElite controllers with low to absent effector CD8+ T cell responses maintain highly functional, broadly directed central memory responses. J Virol. 2012 Jun; 86(12):6959-69.J Virol2012-04-18T00:00:002012Elite controllers with low to absent effector CD8+ T cell responses maintain highly functional, broadly directed central memory responses.21752903Berger CT, Frahm N, Price DA, Mothe B, Ghebremichael M, Hartman KL, Henry LM, Brenchley JM, Ruff LE, Venturi V, Pereyra F, Sidney J, Sette A, Douek DC, Walker BD, Kaufmann DE, Brander CJournal of virologyHigh-functional-avidity cytotoxic T lymphocyte responses to HLA-B-restricted Gag-derived epitopes associated with relative HIV control. J Virol. 2011 Sep; 85(18):9334-45.J Virol2011-07-13T00:00:002011High-functional-avidity cytotoxic T lymphocyte responses to HLA-B-restricted Gag-derived epitopes associated with relative HIV control.22210629Chang JJ, Lacas A, Lindsay RJ, Doyle EH, Axten KL, Pereyra F, Rosenberg ES, Walker BD, Allen TM, Altfeld MAIDS (London, England)Differential regulation of toll-like receptor pathways in acute and chronic HIV-1 infection. AIDS. 2012 Mar 13; 26(5):533-41.AIDS2012-03-13T00:00:002012Differential regulation of toll-like receptor pathways in acute and chronic HIV-1 infection.22412369Henn MR, Boutwell CL, Charlebois P, Lennon NJ, Power KA, Macalalad AR, Berlin AM, Malboeuf CM, Ryan EM, Gnerre S, Zody MC, Erlich RL, Green LM, Berical A, Wang Y, Casali M, Streeck H, Bloom AK, Dudek T, Tully D, Newman R, Axten KL, Gladden AD, Battis L, Kemper M, Zeng Q, Shea TP, Gujja S, Zedlack C, Gasser O, Brander C, Hess C, Günthard HF, Brumme ZL, Brumme CJ, Bazner S, Rychert J, Tinsley JP, Mayer KH, Rosenberg E, Pereyra F, Levin JZ, Young SK, Jessen H, Altfeld M, Birren BW, Walker BD, Allen TMPLoS pathogensWhole genome deep sequencing of HIV-1 reveals the impact of early minor variants upon immune recognition during acute infection. PLoS Pathog. 2012; 8(3):e1002529.PLoS Pathog2012-03-08T00:00:002012Whole genome deep sequencing of HIV-1 reveals the impact of early minor variants upon immune recognition during acute infection.22427677Angin M, Kwon DS, Streeck H, Wen F, King M, Rezai A, Law K, Hongo TC, Pyo A, Piechocka-Trocha A, Toth I, Pereyra F, Ghebremichael M, Rodig SJ, Milner DA, Richter JM, Altfeld M, Kaufmann DE, Walker BD, Addo MMThe Journal of infectious diseasesPreserved function of regulatory T cells in chronic HIV-1 infection despite decreased numbers in blood and tissue. J Infect Dis. 2012 May 15; 205(10):1495-500.J Infect Dis2012-03-15T00:00:002012Preserved function of regulatory T cells in chronic HIV-1 infection despite decreased numbers in blood and tissue.22586036Zhang SC, Martin E, Shimada M, Godfrey SB, Fricke J, Locastro S, Lai NY, Liebesny P, Carlson JM, Brumme CJ, Ogbechie OA, Chen H, Walker BD, Brumme ZL, Kavanagh DG, Le Gall SJournal of immunology (Baltimore, Md. : 1950)Aminopeptidase substrate preference affects HIV epitope presentation and predicts immune escape patterns in HIV-infected individuals. J Immunol. 2012 Jun 15; 188(12):5924-34.J Immunol2012-05-14T00:00:002012Aminopeptidase substrate preference affects HIV epitope presentation and predicts immune escape patterns in HIV-infected individuals.22683743Chen H, Ndhlovu ZM, Liu D, Porter LC, Fang JW, Darko S, Brockman MA, Miura T, Brumme ZL, Schneidewind A, Piechocka-Trocha A, Cesa KT, Sela J, Cung TD, Toth I, Pereyra F, Yu XG, Douek DC, Kaufmann DE, Allen TM, Walker BDNature immunologyTCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infection. Nat Immunol. 2012 Jun 10; 13(7):691-700.Nat Immunol2012-06-10T00:00:002012TCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infection.Authorship 1006551428752134Clayton KL, Garcia JV, Clements JE, Walker BDPathogens & immunityHIV Infection of Macrophages: Implications for Pathogenesis and Cure. Pathog Immun. 2017; 2(2):179-192.Pathog Immun2017-05-24T00:00:002017HIV Infection of Macrophages: Implications for Pathogenesis and Cure.Day CL, Kiepiela P, Leslie AJ, van der Stok M, Nair K, Ismail N, Honeyborne I, Crawford H, Coovadia HM, Goulder PJ, Walker BD, Klenerman P.J Virol. Epub 2006 Oct 18.Proliferative capacity of epitope-specific CD8 T cell responses is inversely related to viral load in chronic HIV-1 infection. J Virol. Epub 2006 Oct 18. 2007; 81(1):434-8.2007-01-01T00:00:002007Proliferative capacity of epitope-specific CD8 T cell responses is inversely related to viral load in chronic HIV-1 infection2501523Hu H, Fine J, Epstein P, Kelsey K, Reynolds P, Walker BJAMATear gas--harassing agent or toxic chemical weapon? JAMA. 1989 Aug 04; 262(5):660-3.JAMA1989-08-04T00:00:001989Tear gas--harassing agent or toxic chemical weapon?20220841Virgin HW, Walker BDNatureImmunology and the elusive AIDS vaccine. Nature. 2010 Mar 11; 464(7286):224-31.Nature2010-03-11T00:00:002010Immunology and the elusive AIDS vaccine.3496541Walker BD, Chakrabarti S, Moss B, Paradis TJ, Flynn T, Durno AG, Blumberg RS, Kaplan JC, Hirsch MS, Schooley RTNatureHIV-specific cytotoxic T lymphocytes in seropositive individuals. Nature. 1987 Jul 23-29; 328(6128):345-8.Nature1987-07-01T00:00:001987HIV-specific cytotoxic T lymphocytes in seropositive individuals.Authorship 10087061228878089Leitman EM, Willberg CB, Tsai MH, Chen H, Buus S, Chen F, Riddell L, Haas D, Fellay J, Goedert JJ, Piechocka-Trocha A, Walker BD, Martin J, Deeks S, Wolinsky SM, Martinson J, Martin M, Qi Y, Sáez-Cirión A, Yang OO, Matthews PC, Carrington M, Goulder PJRJournal of virologyHLA-B*14:02-Restricted Env-Specific CD8+ T-Cell Activity Has Highly Potent Antiviral Efficacy Associated with Immune Control of HIV Infection. 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PLoS Pathog. 2017 Sep; 13(9):e1006629.PLoS Pathog2017-09-20T00:00:002017T-cell responses targeting HIV Nef uniquely correlate with infected cell frequencies after long-term antiretroviral therapy.18385228Schneidewind A, Brockman MA, Sidney J, Wang YE, Chen H, Suscovich TJ, Li B, Adam RI, Allgaier RL, Mothé BR, Kuntzen T, Oniangue-Ndza C, Trocha A, Yu XG, Brander C, Sette A, Walker BD, Allen TMJournal of virologyStructural and functional constraints limit options for cytotoxic T-lymphocyte escape in the immunodominant HLA-B27-restricted epitope in human immunodeficiency virus type 1 capsid. 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Nature. 2009 Apr 02; 458(7238):641-5.Nature2009-02-25T00:00:002009Adaptation of HIV-1 to human leukocyte antigen class I.19352428Ramduth D, Day CL, Thobakgale CF, Mkhwanazi NP, de Pierres C, Reddy S, van der Stok M, Mncube Z, Nair K, Moodley ES, Kaufmann DE, Streeck H, Coovadia HM, Kiepiela P, Goulder PJ, Walker BDPloS oneImmunodominant HIV-1 Cd4+ T cell epitopes in chronic untreated clade C HIV-1 infection. 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J Virol. 1997 Feb; 71(2):1256-64.J Virol1997-02-01T00:00:001997Overlapping epitopes in human immunodeficiency virus type 1 gp120 presented by HLA A, B, and C molecules: effects of viral variation on cytotoxic T-lymphocyte recognition.Authorship 10151161128943879Mabuka JM, Dugast AS, Muema DM, Reddy T, Ramlakhan Y, Euler Z, Ismail N, Moodley A, Dong KL, Morris L, Walker BD, Alter G, Ndung'u TFrontiers in immunologyPlasma CXCL13 but Not B Cell Frequencies in Acute HIV Infection Predicts Emergence of Cross-Neutralizing Antibodies. Front Immunol. 2017; 8:1104.Front Immunol2017-09-08T00:00:002017Plasma CXCL13 but Not B Cell Frequencies in Acute HIV Infection Predicts Emergence of Cross-Neutralizing Antibodies.9089953Jassoy C, Walker BDSpringer seminars in immunopathologyHIV-1-specific cytotoxic T lymphocytes and the control of HIV-1 replication. 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J Acquir Immune Defic Syndr (1988). 1993 Aug; 6(8):865-71.J Acquir Immune Defic Syndr (1988)1993-08-01T00:00:001993Induction of HIV-1 replication in a chronically infected T-cell line by cytotoxic T lymphocytes.11818468Gandhi RT, Walker BDAnnual review of medicineImmunologic control of HIV-1. Annu Rev Med. 2002; 53:149-72.Annu Rev Med2002-01-01T00:00:002002Immunologic control of HIV-1.12021343Lauer GM, Ouchi K, Chung RT, Nguyen TN, Day CL, Purkis DR, Reiser M, Kim AY, Lucas M, Klenerman P, Walker BDJournal of virologyComprehensive analysis of CD8(+)-T-cell responses against hepatitis C virus reveals multiple unpredicted specificities. 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Proc Natl Acad Sci U S A. 1991 Dec 15; 88(24):11276-80.Proc Natl Acad Sci U S A1991-12-15T00:00:001991An optimal viral peptide recognized by CD8+ T cells binds very tightly to the restricting class I major histocompatibility complex protein on intact cells but not to the purified class I protein.15067030Draenert R, Le Gall S, Pfafferott KJ, Leslie AJ, Chetty P, Brander C, Holmes EC, Chang SC, Feeney ME, Addo MM, Ruiz L, Ramduth D, Jeena P, Altfeld M, Thomas S, Tang Y, Verrill CL, Dixon C, Prado JG, Kiepiela P, Martinez-Picado J, Walker BD, Goulder PJThe Journal of experimental medicineImmune selection for altered antigen processing leads to cytotoxic T lymphocyte escape in chronic HIV-1 infection. J Exp Med. 2004 Apr 05; 199(7):905-15.J Exp Med2004-04-05T00:00:002004Immune selection for altered antigen processing leads to cytotoxic T lymphocyte escape in chronic HIV-1 infection.15154967Rodriguez WR, Addo MM, Rathod A, Fitzpatrick CA, Yu XG, Perkins B, Rosenberg ES, Altfeld M, Walker BDJournal of translational medicineCD8+ T lymphocyte responses target functionally important regions of Protease and Integrase in HIV-1 infected subjects. J Transl Med. 2004 May 21; 2(1):15.J Transl Med2004-05-21T00:00:002004CD8+ T lymphocyte responses target functionally important regions of Protease and Integrase in HIV-1 infected subjects.16013921Rodriguez WR, Christodoulides N, Floriano PN, Graham S, Mohanty S, Dixon M, Hsiang M, Peter T, Zavahir S, Thior I, Romanovicz D, Bernard B, Goodey AP, Walker BD, McDevitt JTPLoS medicineA microchip CD4 counting method for HIV monitoring in resource-poor settings. 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J Exp Med. 2003 May 19; 197(10):1365-75.J Exp Med2003-05-12T00:00:002003Determinant of HIV-1 mutational escape from cytotoxic T lymphocytes.Authorship 1019112929020090Leitman EM, Palmer CD, Buus S, Chen F, Riddell L, Sims S, Klenerman P, Sáez-Cirión A, Walker BD, Hess PR, Altfeld M, Matthews PC, Goulder PJRPloS oneSaporin-conjugated tetramers identify efficacious anti-HIV CD8+ T-cell specificities. PLoS One. 2017; 12(10):e0184496.PLoS One2017-10-11T00:00:002017Saporin-conjugated tetramers identify efficacious anti-HIV CD8+ T-cell specificities.16777394Kaufmann SH, Walker BDCurrent opinion in immunologyHost-pathogen interactions. Curr Opin Immunol. 2006 Aug; 18(4):371-3.Curr Opin Immunol2006-06-14T00:00:002006Host-pathogen interactions.17489119Walker BDResearch initiative, treatment action : RITAHIV controllers: an untapped source of clues to overcoming HIV infection. 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J Exp Med. 2007 Nov 26; 204(12):2813-24.J Exp Med2007-11-19T00:00:002007A viral CTL escape mutation leading to immunoglobulin-like transcript 4-mediated functional inhibition of myelomonocytic cells.18434400Rousseau CM, Daniels MG, Carlson JM, Kadie C, Crawford H, Prendergast A, Matthews P, Payne R, Rolland M, Raugi DN, Maust BS, Learn GH, Nickle DC, Coovadia H, Ndung'u T, Frahm N, Brander C, Walker BD, Goulder PJ, Bhattacharya T, Heckerman DE, Korber BT, Mullins JIJournal of virologyHLA class I-driven evolution of human immunodeficiency virus type 1 subtype c proteome: immune escape and viral load. 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AIDS. 2011 Jul 31; 25(12):1515-22.AIDS2011-07-31T00:00:002011Extended high viremics: a substantial fraction of individuals maintain high plasma viral RNA levels after acute HIV-1 subtype C infection.22152067Mothe B, Llano A, Ibarrondo J, Daniels M, Miranda C, Zamarreño J, Bach V, Zuniga R, Pérez-Álvarez S, Berger CT, Puertas MC, Martinez-Picado J, Rolland M, Farfan M, Szinger JJ, Hildebrand WH, Yang OO, Sanchez-Merino V, Brumme CJ, Brumme ZL, Heckerman D, Allen TM, Mullins JI, Gómez G, Goulder PJ, Walker BD, Gatell JM, Clotet B, Korber BT, Sanchez J, Brander CJournal of translational medicineDefinition of the viral targets of protective HIV-1-specific T cell responses. J Transl Med. 2011 Dec 07; 9:208.J Transl Med2011-12-07T00:00:002011Definition of the viral targets of protective HIV-1-specific T cell responses.23233659Ndhlovu ZM, Chibnik LB, Proudfoot J, Vine S, McMullen A, Cesa K, Porichis F, Jones RB, Alvino DM, Hart MG, Stampouloglou E, Piechocka-Trocha A, Kadie C, Pereyra F, Heckerman D, De Jager PL, Walker BD, Kaufmann DEBloodHigh-dimensional immunomonitoring models of HIV-1-specific CD8 T-cell responses accurately identify subjects achieving spontaneous viral control. Blood. 2013 Jan 31; 121(5):801-11.Blood2012-12-11T00:00:002012High-dimensional immunomonitoring models of HIV-1-specific CD8 T-cell responses accurately identify subjects achieving spontaneous viral control.Pozansky MC, Walker BD, Haseltine WA, Sodroski J, Langhoff EJAIDSA rapid method for quantitating the frequency of peripheral blood cells containing HIV-1 DNA. JAIDS. 1991; 4:368-373.1991-01-01T00:00:001991A rapid method for quantitating the frequency of peripheral blood cells containing HIV-1 DNAAutran B, Fridman H, Lotze M, Walker B, guest editors.Proceedings of the Therapeutic Vaccines Against HIV and Cancers Meeting. 2002.2002-12-01T00:00:002002Proceedings of the Therapeutic Vaccines Against HIV and Cancers Meeting15059848Lichterfeld M, Yu XG, Waring MT, Mui SK, Johnston MN, Cohen D, Addo MM, Zaunders J, Alter G, Pae E, Strick D, Allen TM, Rosenberg ES, Walker BD, Altfeld MBloodHIV-1-specific cytotoxicity is preferentially mediated by a subset of CD8(+) T cells producing both interferon-gamma and tumor necrosis factor-alpha. Blood. 2004 Jul 15; 104(2):487-94.Blood2004-04-01T00:00:002004HIV-1-specific cytotoxicity is preferentially mediated by a subset of CD8(+) T cells producing both interferon-gamma and tumor necrosis factor-alpha.16148104Schulze zur Wiesch J, Lauer GM, Day CL, Kim AY, Ouchi K, Duncan JE, Wurcel AG, Timm J, Jones AM, Mothe B, Allen TM, McGovern B, Lewis-Ximenez L, Sidney J, Sette A, Chung RT, Walker BDJournal of immunology (Baltimore, Md. : 1950)Broad repertoire of the CD4+ Th cell response in spontaneously controlled hepatitis C virus infection includes dominant and highly promiscuous epitopes. 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J Virol. 2001 Feb; 75(3):1229-35.J Virol2001-02-01T00:00:002001Detection of diverse hepatitis C virus (HCV)-specific cytotoxic T lymphocytes in peripheral blood of infected persons by screening for responses to all translated proteins of HCV.17982054Frahm N, Kaufmann DE, Yusim K, Muldoon M, Kesmir C, Linde CH, Fischer W, Allen TM, Li B, McMahon BH, Faircloth KL, Hewitt HS, Mackey EW, Miura T, Khatri A, Wolinsky S, McMichael A, Funkhouser RK, Walker BD, Brander C, Korber BTJournal of immunology (Baltimore, Md. : 1950)Increased sequence diversity coverage improves detection of HIV-specific T cell responses. J Immunol. 2007 Nov 15; 179(10):6638-50.J Immunol2007-11-15T00:00:002007Increased sequence diversity coverage improves detection of HIV-specific T cell responses.12514710Bhardwaj N, Walker BDNature medicineImmunotherapy for AIDS virus infections: cautious optimism for cell-based vaccine. 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J Virol. 1994 May; 68(5):3145-53.J Virol1994-05-01T00:00:001994Induction of a major histocompatibility complex class I-restricted cytotoxic T-lymphocyte response to a highly conserved region of human immunodeficiency virus type 1 (HIV-1) gp120 in seronegative humans immunized with a candidate HIV-1 vaccine.17346138Zhao S, Zhai S, Zhuang Y, Wang S, Huang D, Kang W, Li X, Yu XG, Walker BD, Altfeld MA, Sun YCurrent HIV researchInter-clade cross-reactivity of HIV-1-specific T cell responses in human immunodeficiency virus type 1 infection in China. Curr HIV Res. 2007 Mar; 5(2):251-9.Curr HIV Res2007-03-01T00:00:002007Inter-clade cross-reactivity of HIV-1-specific T cell responses in human immunodeficiency virus type 1 infection in China.17363674Bhattacharya T, Daniels M, Heckerman D, Foley B, Frahm N, Kadie C, Carlson J, Yusim K, McMahon B, Gaschen B, Mallal S, Mullins JI, Nickle DC, Herbeck J, Rousseau C, Learn GH, Miura T, Brander C, Walker B, Korber BScience (New York, N.Y.)Founder effects in the assessment of HIV polymorphisms and HLA allele associations. Science. 2007 Mar 16; 315(5818):1583-6.Science2007-03-16T00:00:002007Founder effects in the assessment of HIV polymorphisms and HLA allele associations.17415054Streeck H, Schweighardt B, Jessen H, Allgaier RL, Wrin T, Stawiski EW, Jessen AB, Allen TM, Walker BD, Altfeld MAIDS (London, England)Loss of HIV-1-specific T-cell responses associated with very rapid HIV-1 disease progression. 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PLoS Pathog. 2010 May 27; 6(5):e1000917.PLoS Pathog2010-05-27T00:00:002010Perforin expression directly ex vivo by HIV-specific CD8 T-cells is a correlate of HIV elite control.18275276Pereyra F, Addo MM, Kaufmann DE, Liu Y, Miura T, Rathod A, Baker B, Trocha A, Rosenberg R, Mackey E, Ueda P, Lu Z, Cohen D, Wrin T, Petropoulos CJ, Rosenberg ES, Walker BDThe Journal of infectious diseasesGenetic and immunologic heterogeneity among persons who control HIV infection in the absence of therapy. J Infect Dis. 2008 Feb 15; 197(4):563-71.J Infect Dis2008-02-15T00:00:002008Genetic and immunologic heterogeneity among persons who control HIV infection in the absence of therapy.19572863Foo D, Walker BD, Kuchar DL, Thorburn CW, Tay A, Hayward CS, Macdonald P, Keogh A, Kotlyar E, Spratt P, Jansz PPacing and clinical electrophysiology : PACELeft ventricular mechanical assist devices and cardiac device interactions: an observational case series. Pacing Clin Electrophysiol. 2009 Jul; 32(7):879-87.Pacing Clin Electrophysiol2009-07-01T00:00:002009Left ventricular mechanical assist devices and cardiac device interactions: an observational case series.19695656Singh A, Page T, Moore PL, Allgaier RL, Hiramen K, Coovadia HM, Walker BD, Morris L, Ndung'u TVirologyFunctional and genetic analysis of coreceptor usage by dualtropic HIV-1 subtype C isolates. Virology. 2009 Oct 10; 393(1):56-67.Virology2009-08-19T00:00:002009Functional and genetic analysis of coreceptor usage by dualtropic HIV-1 subtype C isolates.20810731Brockman MA, Brumme ZL, Brumme CJ, Miura T, Sela J, Rosato PC, Kadie CM, Carlson JM, Markle TJ, Streeck H, Kelleher AD, Markowitz M, Jessen H, Rosenberg E, Altfeld M, Harrigan PR, Heckerman D, Walker BD, Allen TMJournal of virologyEarly selection in Gag by protective HLA alleles contributes to reduced HIV-1 replication capacity that may be largely compensated for in chronic infection. J Virol. 2010 Nov; 84(22):11937-49.J Virol2010-09-01T00:00:002010Early selection in Gag by protective HLA alleles contributes to reduced HIV-1 replication capacity that may be largely compensated for in chronic infection.21289112Wright JK, Novitsky V, Brockman MA, Brumme ZL, Brumme CJ, Carlson JM, Heckerman D, Wang B, Losina E, Leshwedi M, van der Stok M, Maphumulo L, Mkhwanazi N, Chonco F, Goulder PJ, Essex M, Walker BD, Ndung'u TJournal of virologyInfluence of Gag-protease-mediated replication capacity on disease progression in individuals recently infected with HIV-1 subtype C. J Virol. 2011 Apr; 85(8):3996-4006.J Virol2011-02-02T00:00:002011Influence of Gag-protease-mediated replication capacity on disease progression in individuals recently infected with HIV-1 subtype C.21403126Streeck H, Kwon DS, Pyo A, Flanders M, Chevalier MF, Law K, Jülg B, Trocha K, Jolin JS, Anahtar MN, Lian J, Toth I, Brumme Z, Chang JJ, Caron T, Rodig SJ, Milner DA, Piechoka-Trocha A, Kaufmann DE, Walker BD, Altfeld MBloodEpithelial adhesion molecules can inhibit HIV-1-specific CD8? T-cell functions. Blood. 2011 May 12; 117(19):5112-22.Blood2011-03-14T00:00:002011Epithelial adhesion molecules can inhibit HIV-1-specific CD8? T-cell functions.21853018Kasprowicz VO, Mitchell JE, Chetty S, Govender P, Huang KH, Fletcher HA, Webster DP, Brown S, Kasmar A, Millington K, Day CL, Mkhwanazi N, McClurg C, Chonco F, Lalvani A, Walker BD, Ndung'u T, Klenerman PPloS oneA molecular assay for sensitive detection of pathogen-specific T-cells. PLoS One. 2011; 6(8):e20606.PLoS One2011-08-11T00:00:002011A molecular assay for sensitive detection of pathogen-specific T-cells.23041316Zhu J, Gaiha GD, John SP, Pertel T, Chin CR, Gao G, Qu H, Walker BD, Elledge SJ, Brass ALCell reportsReactivation of latent HIV-1 by inhibition of BRD4. Cell Rep. 2012 Oct 25; 2(4):807-16.Cell Rep2012-10-04T00:00:002012Reactivation of latent HIV-1 by inhibition of BRD4.Authorship 10359652429302013Ramsuran V, Naranbhai V, Horowitz A, Qi Y, Martin MP, Yuki Y, Gao X, Walker-Sperling V, Del Prete GQ, Schneider DK, Lifson JD, Fellay J, Deeks SG, Martin JN, Goedert JJ, Wolinsky SM, Michael NL, Kirk GD, Buchbinder S, Haas D, Ndung'u T, Goulder P, Parham P, Walker BD, Carlson JM, Carrington MScience (New York, N.Y.)Elevated HLA-A expression impairs HIV control through inhibition of NKG2A-expressing cells. Science. 2018 01 05; 359(6371):86-90.Science2018-01-04T00:00:002018Elevated HLA-A expression impairs HIV control through inhibition of NKG2A-expressing cells.7888228Jassoy C, Heinkelein M, Klinker H, Walker BDAIDS research and human retrovirusesHIV type 1-specific cytotoxic T lymphocytes stimulate HLA class I and intercellular adhesion molecule type 1 expression and increase beta 2-microglobulin levels in vitro. AIDS Res Hum Retroviruses. 1994 Dec; 10(12):1685-93.AIDS Res Hum Retroviruses1994-12-01T00:00:001994HIV type 1-specific cytotoxic T lymphocytes stimulate HLA class I and intercellular adhesion molecule type 1 expression and increase beta 2-microglobulin levels in vitro.20875418Kim AY, Kuntzen T, Timm J, Nolan BE, Baca MA, Reyor LL, Berical AC, Feller AJ, Johnson KL, Schulze zur Wiesch J, Robbins GK, Chung RT, Walker BD, Carrington M, Allen TM, Lauer GMGastroenterologySpontaneous control of HCV is associated with expression of HLA-B 57 and preservation of targeted epitopes. Gastroenterology. 2011 Feb; 140(2):686-696.e1.Gastroenterology2010-09-24T00:00:002010Spontaneous control of HCV is associated with expression of HLA-B 57 and preservation of targeted epitopes.21988996Walker BD, Ahmed R, Plotkin SNature medicineMoving ahead an HIV vaccine: use both arms to beat HIV. Nat Med. 2011 Oct 11; 17(10):1194-5.Nat Med2011-10-11T00:00:002011Moving ahead an HIV vaccine: use both arms to beat HIV.22999948Goulder PJ, Walker BDImmunityHIV and HLA class I: an evolving relationship. Immunity. 2012 Sep 21; 37(3):426-40.Immunity2012-09-21T00:00:002012HIV and HLA class I: an evolving relationship.17287271Lichterfeld M, Yu XG, Mui SK, Williams KL, Trocha A, Brockman MA, Allgaier RL, Waring MT, Koibuchi T, Johnston MN, Cohen D, Allen TM, Rosenberg ES, Walker BD, Altfeld MJournal of virologySelective depletion of high-avidity human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T cells after early HIV-1 infection. J Virol. 2007 Apr; 81(8):4199-214.J Virol2007-02-07T00:00:002007Selective depletion of high-avidity human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T cells after early HIV-1 infection.18219672Northfield JW, Kasprowicz V, Lucas M, Kersting N, Bengsch B, Bengsh B, Kim A, Phillips RE, Walker BD, Thimme R, Lauer G, Klenerman PHepatology (Baltimore, Md.)CD161 expression on hepatitis C virus-specific CD8+ T cells suggests a distinct pathway of T cell differentiation. Hepatology. 2008 Feb; 47(2):396-406.Hepatology2008-02-01T00:00:002008CD161 expression on hepatitis C virus-specific CD8+ T cells suggests a distinct pathway of T cell differentiation.Authorship 10404182229355843Huang SH, Ren Y, Thomas AS, Chan D, Mueller S, Ward AR, Patel S, Bollard CM, Cruz CR, Karandish S, Truong R, Macedo AB, Bosque A, Kovacs C, Benko E, Piechocka-Trocha A, Wong H, Jeng E, Nixon DF, Ho YC, Siliciano RF, Walker BD, Jones RBThe Journal of clinical investigationLatent HIV reservoirs exhibit inherent resistance to elimination by CD8+ T cells. J Clin Invest. 2018 02 01; 128(2):876-889.J Clin Invest2018-01-22T00:00:002018Latent HIV reservoirs exhibit inherent resistance to elimination by CD8+ T cells.7538543Hammond SA, Johnson RP, Kalams SA, Walker BD, Takiguchi M, Safrit JT, Koup RA, Siliciano RFJournal of immunology (Baltimore, Md. : 1950)An epitope-selective, transporter associated with antigen presentation (TAP)-1/2-independent pathway and a more general TAP-1/2-dependent antigen-processing pathway allow recognition of the HIV-1 envelope glycoprotein by CD8+ CTL. J Immunol. 1995 Jun 01; 154(11):6140-56.J Immunol1995-06-01T00:00:001995An epitope-selective, transporter associated with antigen presentation (TAP)-1/2-independent pathway and a more general TAP-1/2-dependent antigen-processing pathway allow recognition of the HIV-1 envelope glycoprotein by CD8+ CTL.7677956Johnson RP, Trocha A, Buchanan TM, Walker BDJournal of virologyRecognition of a highly conserved region of human immunodeficiency virus type 1 gp120 by an HLA-Cw4-restricted cytotoxic T-lymphocyte clone. J Virol. 1993 Jan; 67(1):438-45.J Virol1993-01-01T00:00:001993Recognition of a highly conserved region of human immunodeficiency virus type 1 gp120 by an HLA-Cw4-restricted cytotoxic T-lymphocyte clone.20065064Bansal A, Carlson J, Yan J, Akinsiku OT, Schaefer M, Sabbaj S, Bet A, Levy DN, Heath S, Tang J, Kaslow RA, Walker BD, Ndung'u T, Goulder PJ, Heckerman D, Hunter E, Goepfert PAThe Journal of experimental medicineCD8 T cell response and evolutionary pressure to HIV-1 cryptic epitopes derived from antisense transcription. J Exp Med. 2010 Jan 18; 207(1):51-9.J Exp Med2010-01-11T00:00:002010CD8 T cell response and evolutionary pressure to HIV-1 cryptic epitopes derived from antisense transcription.21965332Varadarajan N, Julg B, Yamanaka YJ, Chen H, Ogunniyi AO, McAndrew E, Porter LC, Piechocka-Trocha A, Hill BJ, Douek DC, Pereyra F, Walker BD, Love JCThe Journal of clinical investigationA high-throughput single-cell analysis of human CD8? T cell functions reveals discordance for cytokine secretion and cytolysis. J Clin Invest. 2011 Nov; 121(11):4322-31.J Clin Invest2011-10-03T00:00:002011A high-throughput single-cell analysis of human CD8? T cell functions reveals discordance for cytokine secretion and cytolysis.22348047Julg B, Poole D, Ghebremichael M, Castilla C, Altfeld M, Sunpath H, Murphy RA, Walker BDPloS oneFactors predicting discordant virological and immunological responses to antiretroviral therapy in HIV-1 clade C infected Zulu/Xhosa in South Africa. PLoS One. 2012; 7(2):e31161.PLoS One2012-02-14T00:00:002012Factors predicting discordant virological and immunological responses to antiretroviral therapy in HIV-1 clade C infected Zulu/Xhosa in South Africa.22355106Varadarajan N, Kwon DS, Law KM, Ogunniyi AO, Anahtar MN, Richter JM, Walker BD, Love JCProceedings of the National Academy of Sciences of the United States of AmericaRapid, efficient functional characterization and recovery of HIV-specific human CD8+ T cells using microengraving. Proc Natl Acad Sci U S A. 2012 Mar 06; 109(10):3885-90.Proc Natl Acad Sci U S A2012-02-21T00:00:002012Rapid, efficient functional characterization and recovery of HIV-specific human CD8+ T cells using microengraving.9878017Merrill DP, Martinez-Picado J, Tremblay C, Sax PE, Boswell SL, Wong JT, D'Aquila RT, Walker BD, Hirsch MSThe Journal of infectious diseasesImproved CD4 lymphocyte outgrowth in response to effective antiretroviral therapy. J Infect Dis. 1999 Feb; 179(2):345-51.J Infect Dis1999-02-01T00:00:001999Improved CD4 lymphocyte outgrowth in response to effective antiretroviral therapy.Authorship 1043096929378643Martin-Gayo E, Cole MB, Kolb KE, Ouyang Z, Cronin J, Kazer SW, Ordovas-Montanes J, Lichterfeld M, Walker BD, Yosef N, Shalek AK, Yu XGGenome biologyA Reproducibility-Based Computational Framework Identifies an Inducible, Enhanced Antiviral State in Dendritic Cells from HIV-1 Elite Controllers. Genome Biol. 2018 01 29; 19(1):10.Genome Biol2018-01-29T00:00:002018A Reproducibility-Based Computational Framework Identifies an Inducible, Enhanced Antiviral State in Dendritic Cells from HIV-1 Elite Controllers.9858506Kalams SA, Walker BDThe Journal of experimental medicineThe critical need for CD4 help in maintaining effective cytotoxic T lymphocyte responses. J Exp Med. 1998 Dec 21; 188(12):2199-204.J Exp Med1998-12-21T00:00:001998The critical need for CD4 help in maintaining effective cytotoxic T lymphocyte responses.9012587Jassoy C, Walker BDCritical reviews in oncogenesisT lymphocytes and their cytokines in human immunodeficiency virus (HIV) infection: implications for associated neoplasias. Crit Rev Oncog. 1995; 6(3-6):275-89.Crit Rev Oncog1995-01-01T00:00:001995T lymphocytes and their cytokines in human immunodeficiency virus (HIV) infection: implications for associated neoplasias.10799606Goulder PJ, Tang Y, Pelton SI, Walker BDJournal of virologyHLA-B57-restricted cytotoxic T-lymphocyte activity in a single infected subject toward two optimal epitopes, one of which is entirely contained within the other. J Virol. 2000 Jun; 74(11):5291-9.J Virol2000-06-01T00:00:002000HLA-B57-restricted cytotoxic T-lymphocyte activity in a single infected subject toward two optimal epitopes, one of which is entirely contained within the other.11152507Goulder PJ, Addo MM, Altfeld MA, Rosenberg ES, Tang Y, Govender U, Mngqundaniso N, Annamalai K, Vogel TU, Hammond M, Bunce M, Coovadia HM, Walker BDJournal of virologyRapid definition of five novel HLA-A*3002-restricted human immunodeficiency virus-specific cytotoxic T-lymphocyte epitopes by elispot and intracellular cytokine staining assays. J Virol. 2001 Feb; 75(3):1339-47.J Virol2001-02-01T00:00:002001Rapid definition of five novel HLA-A*3002-restricted human immunodeficiency virus-specific cytotoxic T-lymphocyte epitopes by elispot and intracellular cytokine staining assays.15905562Sumida SM, Truitt DM, Lemckert AA, Vogels R, Custers JH, Addo MM, Lockman S, Peter T, Peyerl FW, Kishko MG, Jackson SS, Gorgone DA, Lifton MA, Essex M, Walker BD, Goudsmit J, Havenga MJ, Barouch DHJournal of immunology (Baltimore, Md. : 1950)Neutralizing antibodies to adenovirus serotype 5 vaccine vectors are directed primarily against the adenovirus hexon protein. J Immunol. 2005 Jun 01; 174(11):7179-85.J Immunol2005-06-01T00:00:002005Neutralizing antibodies to adenovirus serotype 5 vaccine vectors are directed primarily against the adenovirus hexon protein.15031033Hess C, Altfeld M, Thomas SY, Addo MM, Rosenberg ES, Allen TM, Draenert R, Eldrige RL, van Lunzen J, Stellbrink HJ, Walker BD, Luster ADLancet (London, England)HIV-1 specific CD8+ T cells with an effector phenotype and control of viral replication. Lancet. 2004 Mar 13; 363(9412):863-6.Lancet2004-03-13T00:00:002004HIV-1 specific CD8+ T cells with an effector phenotype and control of viral replication.15331779Zavala-Ruiz Z, Strug I, Walker BD, Norris PJ, Stern LJProceedings of the National Academy of Sciences of the United States of AmericaA hairpin turn in a class II MHC-bound peptide orients residues outside the binding groove for T cell recognition. Proc Natl Acad Sci U S A. 2004 Sep 07; 101(36):13279-84.Proc Natl Acad Sci U S A2004-08-26T00:00:002004A hairpin turn in a class II MHC-bound peptide orients residues outside the binding groove for T cell recognition.15459014Kim AY, Lauer GM, Ouchi K, Addo MM, Lucas M, Schulze Zur Wiesch J, Timm J, Boczanowski M, Duncan JE, Wurcel AG, Casson D, Chung RT, Draenert R, Klenerman P, Walker BDBloodThe magnitude and breadth of hepatitis C virus-specific CD8+ T cells depend on absolute CD4+ T-cell count in individuals coinfected with HIV-1. Blood. 2005 Feb 01; 105(3):1170-8.Blood2004-09-30T00:00:002004The magnitude and breadth of hepatitis C virus-specific CD8+ T cells depend on absolute CD4+ T-cell count in individuals coinfected with HIV-1.15611288Timm J, Lauer GM, Kavanagh DG, Sheridan I, Kim AY, Lucas M, Pillay T, Ouchi K, Reyor LL, Schulze zur Wiesch J, Gandhi RT, Chung RT, Bhardwaj N, Klenerman P, Walker BD, Allen TMThe Journal of experimental medicineCD8 epitope escape and reversion in acute HCV infection. J Exp Med. 2004 Dec 20; 200(12):1593-604.J Exp Med2004-12-20T00:00:002004CD8 epitope escape and reversion in acute HCV infection.9889969Walker BD, Rosenberg ES, Hay CM, Basgoz N, Yang OOAdvances in experimental medicine and biologyImmune control of HIV-1 replication. Adv Exp Med Biol. 1998; 452:159-67.Adv Exp Med Biol1998-01-01T00:00:001998Immune control of HIV-1 replication.10203039Rosenberg ES, LaRosa L, Flynn T, Robbins G, Walker BDImmunology lettersCharacterization of HIV-1-specific T-helper cells in acute and chronic infection. Immunol Lett. 1999 Mar; 66(1-3):89-93.Immunol Lett1999-03-01T00:00:001999Characterization of HIV-1-specific T-helper cells in acute and chronic infection.16537629Martinez-Picado J, Prado JG, Fry EE, Pfafferott K, Leslie A, Chetty S, Thobakgale C, Honeyborne I, Crawford H, Matthews P, Pillay T, Rousseau C, Mullins JI, Brander C, Walker BD, Stuart DI, Kiepiela P, Goulder PJournal of virologyFitness cost of escape mutations in p24 Gag in association with control of human immunodeficiency virus type 1. J Virol. 2006 Apr; 80(7):3617-23.J Virol2006-04-01T00:00:002006Fitness cost of escape mutations in p24 Gag in association with control of human immunodeficiency virus type 1.Ngumbela KC, Day CL, Mncube Z, Nair K, Ramduth D, Thobakgale C, Moodley E, Reddy S, de Pierres C, Mkhwanazi N, Bishop K, van der Stok M, Ismail N, Honeyborne I, Crawford H, Kavanagh DG, Rousseau C, Nickle D, Mullins J, Heckerman D, Korber B, Coovadia H, Kiepiela P, Goulder PJ, Walker BDAIDS Res Hum RestrovirusesTargeting of a CD8 T cell env epitope presented by HLA A-B*5802 is associated with markers of HIV disease progression and lack of selection pressure. AIDS Res Hum Restroviruses. 2008; 24(1):72-82.2008-01-01T00:00:002008Targeting of a CD8 T cell env epitope presented by HLA A-B*5802 is associated with markers of HIV disease progression and lack of selection pressure9692857Walter JB, Garboczi DN, Fan QR, Zhou X, Walker BD, Eisen HNJournal of immunological methodsA mutant human beta2-microglobulin can be used to generate diverse multimeric class I peptide complexes as specific probes for T cell receptors. J Immunol Methods. 1998 May 01; 214(1-2):41-50.J Immunol Methods1998-05-01T00:00:001998A mutant human beta2-microglobulin can be used to generate diverse multimeric class I peptide complexes as specific probes for T cell receptors.9794421Harrer T, Harrer E, Barbosa P, Kaufmann F, Wagner R, Brüggemann S, Kalden JR, Feinberg M, Johnson RP, Buchbinder S, Walker BDJournal of immunology (Baltimore, Md. : 1950)Recognition of two overlapping CTL epitopes in HIV-1 p17 by CTL from a long-term nonprogressing HIV-1-infected individual. J Immunol. 1998 Nov 01; 161(9):4875-81.J Immunol1998-11-01T00:00:001998Recognition of two overlapping CTL epitopes in HIV-1 p17 by CTL from a long-term nonprogressing HIV-1-infected individual.11460164Goulder PJ, Brander C, Tang Y, Tremblay C, Colbert RA, Addo MM, Rosenberg ES, Nguyen T, Allen R, Trocha A, Altfeld M, He S, Bunce M, Funkhouser R, Pelton SI, Burchett SK, McIntosh K, Korber BT, Walker BDNatureEvolution and transmission of stable CTL escape mutations in HIV infection. Nature. 2001 Jul 19; 412(6844):334-8.Nature2001-07-19T00:00:002001Evolution and transmission of stable CTL escape mutations in HIV infection.11581388Montefiori DC, Hill TS, Vo HT, Walker BD, Rosenberg ESJournal of virologyNeutralizing antibodies associated with viremia control in a subset of individuals after treatment of acute human immunodeficiency virus type 1 infection. J Virol. 2001 Nov; 75(21):10200-7.J Virol2001-11-01T00:00:002001Neutralizing antibodies associated with viremia control in a subset of individuals after treatment of acute human immunodeficiency virus type 1 infection.12192009Geiben-Lynn R, Brown N, Walker BD, Luster ADThe Journal of biological chemistryPurification of a modified form of bovine antithrombin III as an HIV-1 CD8+ T-cell antiviral factor. J Biol Chem. 2002 Nov 01; 277(44):42352-7.J Biol Chem2002-08-20T00:00:002002Purification of a modified form of bovine antithrombin III as an HIV-1 CD8+ T-cell antiviral factor.Kim, A., J. Schulze zur Wiesch, T. Kuntzen, J. Timm, D.E. Kaufmann, J. Duncan, A.M. Jones, A. Wurcel, B.T. Davis, R.T. Gandhi, G.T. Robbins, T. Allen, R. Chung, G.M. Lauer, and B.D. Walker.Impaired HCV-specific T cell responses and recurrent HCV in HIV coinfection. 2006; PLoS Med in press..2006-12-01T00:00:002006Impaired HCV-specific T cell responses and recurrent HCV in HIV coinfection7527747Price P, Johnson RP, Scadden DT, Jassoy C, Rosenthal T, Kalams S, Walker BDClinical immunology and immunopathologyCytotoxic CD8+ T lymphocytes reactive with human immunodeficiency virus-1 produce granulocyte/macrophage colony-stimulating factor and variable amounts of interleukins 2, 3, and 4 following stimulation with the cognate epitope. Clin Immunol Immunopathol. 1995 Jan; 74(1):100-6.Clin Immunol Immunopathol1995-01-01T00:00:001995Cytotoxic CD8+ T lymphocytes reactive with human immunodeficiency virus-1 produce granulocyte/macrophage colony-stimulating factor and variable amounts of interleukins 2, 3, and 4 following stimulation with the cognate epitope.