JES29JeffreySaffitzJeffrey E Saffitz, M.D., Ph.D.42.34022770000000-71.1058540000000075171Saffitz, JeffreyE617/667-4343Mallinckrodt Professor of Pathologycatalyst:eCommonsLogineCommons Loginprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:address2address line 2vivo:address3address line 3vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:middleNamemiddle name or initialvivo:personInPositionpositionsvivo:phoneNumberphonePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofvivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson1451272Fujii S, Sawa H, Saffitz JE, Lucore CL, Sobel BECirculationInduction of endothelial cell expression of the plasminogen activator inhibitor type 1 gene by thrombosis in vivo. Circulation. 1992 Dec; 86(6):2000-10.Circulation1992-12-01T00:00:001992Induction of endothelial cell expression of the plasminogen activator inhibitor type 1 gene by thrombosis in vivo.10728405Saffitz JE, Yamada KACardiovascular researchClosing the gap in understanding the regulation of intercellular communication. Cardiovasc Res. 2000 Mar; 45(4):807-9.Cardiovasc Res2000-03-01T00:00:002000Closing the gap in understanding the regulation of intercellular communication.11334830Lerner DL, Beardslee MA, Saffitz JECardiovascular researchThe role of altered intercellular coupling in arrhythmias induced by acute myocardial ischemia. Cardiovasc Res. 2001 May; 50(2):263-9.Cardiovasc Res2001-05-01T00:00:002001The role of altered intercellular coupling in arrhythmias induced by acute myocardial ischemia.3504447Fuhrmann DR, Brown MA, Miller MI, Roysam B, Saffitz JE, Thomas LJJournal of electron microscopy techniqueData acquisition system for maximum-likelihood analysis of electron microscopic autoradiographs. J Electron Microsc Tech. 1987 Nov; 7(3):199-204.J Electron Microsc Tech1987-11-01T00:00:001987Data acquisition system for maximum-likelihood analysis of electron microscopic autoradiographs.3548974Fox KA, Saffitz JE, Corr PBCardiology clinicsPathophysiology of myocardial reperfusion. Cardiol Clin. 1987 Feb; 5(1):31-48.Cardiol Clin1987-02-01T00:00:001987Pathophysiology of myocardial reperfusion.Authorship 10750726475726Shanes JG, Lyons MF, Saffitz J, Fischbein LC, Kleiger REAmerican heart journalPersistent endomyocardial biopsy-proven vasculitis following cure of endocarditis. Am Heart J. 1984 Sep; 108(3 Pt 1):614-9.Am Heart J1984-09-01T00:00:001984Persistent endomyocardial biopsy-proven vasculitis following cure of endocarditis.14742426Petrich BG, Eloff BC, Lerner DL, Kovacs A, Saffitz JE, Rosenbaum DS, Wang YThe Journal of biological chemistryTargeted activation of c-Jun N-terminal kinase in vivo induces restrictive cardiomyopathy and conduction defects. J Biol Chem. 2004 Apr 09; 279(15):15330-8.J Biol Chem2004-01-23T00:00:002004Targeted activation of c-Jun N-terminal kinase in vivo induces restrictive cardiomyopathy and conduction defects.19178614Asimaki A, Syrris P, Ward D, Guereta LG, Saffitz JE, McKenna WJJournal of cutaneous pathologyUnique epidermolytic bullous dermatosis with associated lethal cardiomyopathy related to novel desmoplakin mutations. J Cutan Pathol. 2009 May; 36(5):553-9.J Cutan Pathol2008-10-29T00:00:002008Unique epidermolytic bullous dermatosis with associated lethal cardiomyopathy related to novel desmoplakin mutations.19279339Asimaki A, Tandri H, Huang H, Halushka MK, Gautam S, Basso C, Thiene G, Tsatsopoulou A, Protonotarios N, McKenna WJ, Calkins H, Saffitz JEThe New England journal of medicineA new diagnostic test for arrhythmogenic right ventricular cardiomyopathy. N Engl J Med. 2009 Mar 12; 360(11):1075-84.N Engl J Med2009-03-12T00:00:002009A new diagnostic test for arrhythmogenic right ventricular cardiomyopathy.Authorship 11052743488717Marshall WG, Saffitz J, Kouchoukos NTThe Annals of thoracic surgeryManagement during reoperation of aortocoronary saphenous vein grafts with minimal atherosclerosis by angiography. Ann Thorac Surg. 1986 Aug; 42(2):163-7.Ann Thorac Surg1986-08-01T00:00:001986Management during reoperation of aortocoronary saphenous vein grafts with minimal atherosclerosis by angiography.6858919Saffitz JE, Ferrans VJ, Rodriguez ER, Lewis FR, Roberts WCThe American journal of cardiologyHistiocytoid cardiomyopathy: a cause of sudden death in apparently healthy infants. Am J Cardiol. 1983 Jul; 52(1):215-7.Am J Cardiol1983-07-01T00:00:001983Histiocytoid cardiomyopathy: a cause of sudden death in apparently healthy infants.7551319Saffitz JE, Davis LM, Darrow BJ, Kanter HL, Laing JG, Beyer ECJournal of cardiovascular electrophysiologyThe molecular basis of anisotropy: role of gap junctions. J Cardiovasc Electrophysiol. 1995 Jun; 6(6):498-510.J Cardiovasc Electrophysiol1995-06-01T00:00:001995The molecular basis of anisotropy: role of gap junctions.8113537Beau SL, Saffitz JEJournal of the American College of CardiologyTransmural heterogeneity of norepinephrine uptake in failing human hearts. J Am Coll Cardiol. 1994 Mar 01; 23(3):579-85.J Am Coll Cardiol1994-03-01T00:00:001994Transmural heterogeneity of norepinephrine uptake in failing human hearts.9396604Weck KE, Dal Canto AJ, Gould JD, O'Guin AK, Roth KA, Saffitz JE, Speck SH, Virgin HWNature medicineMurine gamma-herpesvirus 68 causes severe large-vessel arteritis in mice lacking interferon-gamma responsiveness: a new model for virus-induced vascular disease. Nat Med. 1997 Dec; 3(12):1346-53.Nat Med1997-12-01T00:00:001997Murine gamma-herpesvirus 68 causes severe large-vessel arteritis in mice lacking interferon-gamma responsiveness: a new model for virus-induced vascular disease.Authorship 10398929495295Saffitz JE, Yamada KACirculationDo alterations in intercellular coupling play a role in cardiac contractile dysfunction? Circulation. 1998 Feb 24; 97(7):630-2.Circulation1998-02-24T00:00:001998Do alterations in intercellular coupling play a role in cardiac contractile dysfunction?9852883Kwong KF, Schuessler RB, Kanellopoulos GK, Saffitz JE, Sundt TMCirculationNontransmural laser treatment incompletely denervates canine myocardium. Circulation. 1998 Nov 10; 98(19 Suppl):II67-71; discussion II71-2.Circulation1998-11-10T00:00:001998Nontransmural laser treatment incompletely denervates canine myocardium.17053190Beauchamp P, Yamada KA, Baertschi AJ, Green K, Kanter EM, Saffitz JE, Kléber AGCirculation researchRelative contributions of connexins 40 and 43 to atrial impulse propagation in synthetic strands of neonatal and fetal murine cardiomyocytes. Circ Res. 2006 Nov 24; 99(11):1216-24.Circ Res2006-10-19T00:00:002006Relative contributions of connexins 40 and 43 to atrial impulse propagation in synthetic strands of neonatal and fetal murine cardiomyocytes.17765619Hund TJ, Lerner DL, Yamada KA, Schuessler RB, Saffitz JEHeart rhythmProtein kinase Cepsilon mediates salutary effects on electrical coupling induced by ischemic preconditioning. Heart Rhythm. 2007 Sep; 4(9):1183-93.Heart Rhythm2007-06-08T00:00:002007Protein kinase Cepsilon mediates salutary effects on electrical coupling induced by ischemic preconditioning.2382705Miyazaki Y, Gross RW, Sobel BE, Saffitz JEThe American journal of physiologySelective turnover of sarcolemmal phospholipids with lethal cardiac myocyte injury. Am J Physiol. 1990 Aug; 259(2 Pt 1):C325-31.Am J Physiol1990-08-01T00:00:001990Selective turnover of sarcolemmal phospholipids with lethal cardiac myocyte injury.11851357Betsuyaku T, Kovacs A, Saffitz JE, Yamada KAJournal of molecular and cellular cardiologyCardiac structure and function in young and senescent mice heterozygous for a connexin43 null mutation. J Mol Cell Cardiol. 2002 Feb; 34(2):175-84.J Mol Cell Cardiol2002-02-01T00:00:002002Cardiac structure and function in young and senescent mice heterozygous for a connexin43 null mutation.20172911Marcus FI, McKenna WJ, Sherrill D, Basso C, Bauce B, Bluemke DA, Calkins H, Corrado D, Cox MG, Daubert JP, Fontaine G, Gear K, Hauer R, Nava A, Picard MH, Protonotarios N, Saffitz JE, Sanborn DM, Steinberg JS, Tandri H, Thiene G, Towbin JA, Tsatsopoulou A, Wichter T, Zareba WCirculationDiagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia: proposed modification of the task force criteria. Circulation. 2010 Apr 06; 121(13):1533-41.Circulation2010-02-19T00:00:002010Diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia: proposed modification of the task force criteria.20172912Marcus FI, McKenna WJ, Sherrill D, Basso C, Bauce B, Bluemke DA, Calkins H, Corrado D, Cox MG, Daubert JP, Fontaine G, Gear K, Hauer R, Nava A, Picard MH, Protonotarios N, Saffitz JE, Sanborn DM, Steinberg JS, Tandri H, Thiene G, Towbin JA, Tsatsopoulou A, Wichter T, Zareba WEuropean heart journalDiagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia: proposed modification of the Task Force Criteria. Eur Heart J. 2010 Apr; 31(7):806-14.Eur Heart J2010-02-19T00:00:002010Diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia: proposed modification of the Task Force Criteria.20423733Otten E, Asimaki A, Maass A, van Langen IM, van der Wal A, de Jonge N, van den Berg MP, Saffitz JE, Wilde AA, Jongbloed JD, van Tintelen JPHeart rhythmDesmin mutations as a cause of right ventricular heart failure affect the intercalated disks. Heart Rhythm. 2010 Aug; 7(8):1058-64.Heart Rhythm2010-04-24T00:00:002010Desmin mutations as a cause of right ventricular heart failure affect the intercalated disks.2736736Dunkel CG, Saffitz JE, Evers ASCirculation researchfMet-Leu-Phe receptor expression by an interstitial cell in rabbit right atrium following left ventricular myocardial infarction. Circ Res. 1989 Jul; 65(1):215-23.Circ Res1989-07-01T00:00:001989fMet-Leu-Phe receptor expression by an interstitial cell in rabbit right atrium following left ventricular myocardial infarction.15298432Tang D, Yang C, Zheng J, Woodard PK, Sicard GA, Saffitz JE, Yuan CAnnals of biomedical engineering3D MRI-based multicomponent FSI models for atherosclerotic plaques. Ann Biomed Eng. 2004 Jul; 32(7):947-60.Ann Biomed Eng2004-07-01T00:00:0020043D MRI-based multicomponent FSI models for atherosclerotic plaques.15760270Leone TC, Lehman JJ, Finck BN, Schaeffer PJ, Wende AR, Boudina S, Courtois M, Wozniak DF, Sambandam N, Bernal-Mizrachi C, Chen Z, Holloszy JO, Medeiros DM, Schmidt RE, Saffitz JE, Abel ED, Semenkovich CF, Kelly DPPLoS biologyPGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis. PLoS Biol. 2005 Apr; 3(4):e101.PLoS Biol2005-03-15T00:00:002005PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis.19879535van Tintelen JP, Van Gelder IC, Asimaki A, Suurmeijer AJ, Wiesfeld AC, Jongbloed JD, van den Wijngaard A, Kuks JB, van Spaendonck-Zwarts KY, Notermans N, Boven L, van den Heuvel F, Veenstra-Knol HE, Saffitz JE, Hofstra RM, van den Berg MPHeart rhythmSevere cardiac phenotype with right ventricular predominance in a large cohort of patients with a single missense mutation in the DES gene. Heart Rhythm. 2009 Nov; 6(11):1574-83.Heart Rhythm2009-07-28T00:00:002009Severe cardiac phenotype with right ventricular predominance in a large cohort of patients with a single missense mutation in the DES gene.20051321Saffitz JE, Asimaki A, Huang HCardiovascular pathology : the official journal of the Society for Cardiovascular PathologyArrhythmogenic right ventricular cardiomyopathy: new insights into mechanisms of disease. Cardiovasc Pathol. 2010 May-Jun; 19(3):166-70.Cardiovasc Pathol2010-01-06T00:00:002010Arrhythmogenic right ventricular cardiomyopathy: new insights into mechanisms of disease.20031615Saffitz JECirculation. Cardiovascular geneticsDesmosome mutations in arrhythmogenic right ventricular cardiomyopathy: important insight but only part of the picture. Circ Cardiovasc Genet. 2009 Oct; 2(5):415-7.Circ Cardiovasc Genet2009-10-01T00:00:002009Desmosome mutations in arrhythmogenic right ventricular cardiomyopathy: important insight but only part of the picture.22100709Asimaki A, Saffitz JEHeart rhythmGap junctions and arrhythmogenic cardiomyopathy. Heart Rhythm. 2012 Jun; 9(6):992-5.Heart Rhythm2011-11-16T00:00:002011Gap junctions and arrhythmogenic cardiomyopathy.4020097Knabb MT, Ahumada GG, Sobel BE, Saffitz JEThe journal of histochemistry and cytochemistry : official journal of the Histochemistry SocietyA fixation procedure suitable for autoradiography of endogenous long-chain acyl carnitine. J Histochem Cytochem. 1985 Aug; 33(8):744-8.J Histochem Cytochem1985-08-01T00:00:001985A fixation procedure suitable for autoradiography of endogenous long-chain acyl carnitine.7780626Davis LM, Saffitz JE, Beyer ECJournal of cardiovascular electrophysiologyModulation of connexin43 expression: effects on cellular coupling. J Cardiovasc Electrophysiol. 1995 Feb; 6(2):103-14.J Cardiovasc Electrophysiol1995-02-01T00:00:001995Modulation of connexin43 expression: effects on cellular coupling.17502245Laing JG, Saffitz JE, Steinberg TH, Yamada KACardiovascular pathology : the official journal of the Society for Cardiovascular PathologyDiminished zonula occludens-1 expression in the failing human heart. Cardiovasc Pathol. 2007 May-Jun; 16(3):159-64.Cardiovasc Pathol2007-03-21T00:00:002007Diminished zonula occludens-1 expression in the failing human heart.Authorship 1064939129758788Saffitz JEPersonalized medicineGenomic pathology: a disruptive innovation. Per Med. 2012 May; 9(3):237-239.Per Med2012-05-01T00:00:002012Genomic pathology: a disruptive innovation.Authorship 1042803Authorship 103157112670329Barzilai B, Marshall WG, Saffitz JE, Kouchoukos NCirculationAvoidance of embolic complications by ultrasonic characterization of the ascending aorta. Circulation. 1989 Sep; 80(3 Pt 1):I275-9.Circulation1989-09-01T00:00:001989Avoidance of embolic complications by ultrasonic characterization of the ascending aorta.14761782Kaplan SR, Gard JJ, Carvajal-Huerta L, Ruiz-Cabezas JC, Thiene G, Saffitz JECardiovascular pathology : the official journal of the Society for Cardiovascular PathologyStructural and molecular pathology of the heart in Carvajal syndrome. Cardiovasc Pathol. 2004 Jan-Feb; 13(1):26-32.Cardiovasc Pathol2004-01-01T00:00:002004Structural and molecular pathology of the heart in Carvajal syndrome.15220483Sanbe A, Osinska H, Saffitz JE, Glabe CG, Kayed R, Maloyan A, Robbins JProceedings of the National Academy of Sciences of the United States of AmericaDesmin-related cardiomyopathy in transgenic mice: a cardiac amyloidosis. Proc Natl Acad Sci U S A. 2004 Jul 06; 101(27):10132-6.Proc Natl Acad Sci U S A2004-06-25T00:00:002004Desmin-related cardiomyopathy in transgenic mice: a cardiac amyloidosis.3113517Laposata M, Krueger CM, Saffitz JEBloodSelective uptake of [3H]arachidonic acid into the dense tubular system of human platelets. Blood. 1987 Sep; 70(3):832-7.Blood1987-09-01T00:00:001987Selective uptake of [3H]arachidonic acid into the dense tubular system of human platelets.10515564Johnson CM, Green KG, Kanter EM, Bou-Abboud E, Saffitz JE, Yamada KAJournal of cardiovascular electrophysiologyVoltage-gated Na+ channel activity and connexin expression in Cx43-deficient cardiac myocytes. J Cardiovasc Electrophysiol. 1999 Oct; 10(10):1390-401.J Cardiovasc Electrophysiol1999-10-01T00:00:001999Voltage-gated Na+ channel activity and connexin expression in Cx43-deficient cardiac myocytes.11179068Wu J, Schuessler RB, Rodefeld MD, Saffitz JE, Boineau JPAmerican journal of physiology. Heart and circulatory physiologyMorphological and membrane characteristics of spider and spindle cells isolated from rabbit sinus node. Am J Physiol Heart Circ Physiol. 2001 Mar; 280(3):H1232-40.Am J Physiol Heart Circ Physiol2001-03-01T00:00:002001Morphological and membrane characteristics of spider and spindle cells isolated from rabbit sinus node.Authorship 1073123229915093Thiene G, Saffitz JECirculationAutopsy as a Source of Discovery in Cardiovascular Medicine: Then and Now. Circulation. 2018 06 19; 137(25):2683-2685.Circulation2018-06-19T00:00:002018Autopsy as a Source of Discovery in Cardiovascular Medicine: Then and Now.23178689Noorman M, Hakim S, Kessler E, Groeneweg JA, Cox MG, Asimaki A, van Rijen HV, van Stuijvenberg L, Chkourko H, van der Heyden MA, Vos MA, de Jonge N, van der Smagt JJ, Dooijes D, Vink A, de Weger RA, Varro A, de Bakker JM, Saffitz JE, Hund TJ, Mohler PJ, Delmar M, Hauer RN, van Veen TAHeart rhythmRemodeling of the cardiac sodium channel, connexin43, and plakoglobin at the intercalated disk in patients with arrhythmogenic cardiomyopathy. Heart Rhythm. 2013 Mar; 10(3):412-9.Heart Rhythm2012-11-23T00:00:002012Remodeling of the cardiac sodium channel, connexin43, and plakoglobin at the intercalated disk in patients with arrhythmogenic cardiomyopathy.6837470Saffitz JE, Sazama K, Roberts WCThe American journal of cardiologyAmyloidosis limited to small arteries causing angina pectoris and sudden death. Am J Cardiol. 1983 Apr; 51(7):1234-5.Am J Cardiol1983-04-01T00:00:001983Amyloidosis limited to small arteries causing angina pectoris and sudden death.7554150Beau SL, Hand DE, Schuessler RB, Bromberg BI, Kwon B, Boineau JP, Saffitz JECirculation researchRelative densities of muscarinic cholinergic and beta-adrenergic receptors in the canine sinoatrial node and their relation to sites of pacemaker activity. Circ Res. 1995 Nov; 77(5):957-63.Circ Res1995-11-01T00:00:001995Relative densities of muscarinic cholinergic and beta-adrenergic receptors in the canine sinoatrial node and their relation to sites of pacemaker activity.3311006Corr PB, Saffitz JE, Sobel BEBasic research in cardiologyLysophospholipids, long chain acylcarnitines and membrane dysfunction in the ischaemic heart. Basic Res Cardiol. 1987; 82 Suppl 1:199-208.Basic Res Cardiol1987-01-01T00:00:001987Lysophospholipids, long chain acylcarnitines and membrane dysfunction in the ischaemic heart.22820313van der Zwaag PA, van Rijsingen IA, Asimaki A, Jongbloed JD, van Veldhuisen DJ, Wiesfeld AC, Cox MG, van Lochem LT, de Boer RA, Hofstra RM, Christiaans I, van Spaendonck-Zwarts KY, Lekanne dit Deprez RH, Judge DP, Calkins H, Suurmeijer AJ, Hauer RN, Saffitz JE, Wilde AA, van den Berg MP, van Tintelen JPEuropean journal of heart failurePhospholamban R14del mutation in patients diagnosed with dilated cardiomyopathy or arrhythmogenic right ventricular cardiomyopathy: evidence supporting the concept of arrhythmogenic cardiomyopathy. Eur J Heart Fail. 2012 Nov; 14(11):1199-207.Eur J Heart Fail2012-07-20T00:00:002012Phospholamban R14del mutation in patients diagnosed with dilated cardiomyopathy or arrhythmogenic right ventricular cardiomyopathy: evidence supporting the concept of arrhythmogenic cardiomyopathy.14726475Russell LK, Mansfield CM, Lehman JJ, Kovacs A, Courtois M, Saffitz JE, Medeiros DM, Valencik ML, McDonald JA, Kelly DPCirculation researchCardiac-specific induction of the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha promotes mitochondrial biogenesis and reversible cardiomyopathy in a developmental stage-dependent manner. Circ Res. 2004 Mar 05; 94(4):525-33.Circ Res2004-01-15T00:00:002004Cardiac-specific induction of the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha promotes mitochondrial biogenesis and reversible cardiomyopathy in a developmental stage-dependent manner.2022731Luke RA, Saffitz JEThe Journal of clinical investigationRemodeling of ventricular conduction pathways in healed canine infarct border zones. J Clin Invest. 1991 May; 87(5):1594-602.J Clin Invest1991-05-01T00:00:001991Remodeling of ventricular conduction pathways in healed canine infarct border zones.17924338Asimaki A, Syrris P, Wichter T, Matthias P, Saffitz JE, McKenna WJAmerican journal of human geneticsA novel dominant mutation in plakoglobin causes arrhythmogenic right ventricular cardiomyopathy. Am J Hum Genet. 2007 Nov; 81(5):964-73.Am J Hum Genet2007-09-28T00:00:002007A novel dominant mutation in plakoglobin causes arrhythmogenic right ventricular cardiomyopathy.18554203Tandri H, Asimaki A, Dalal D, Saffitz JE, Halushka MK, Calkins HJournal of cardiovascular electrophysiologyGap junction remodeling in a case of arrhythmogenic right ventricular dysplasia due to plakophilin-2 mutation. J Cardiovasc Electrophysiol. 2008 Nov; 19(11):1212-4.J Cardiovasc Electrophysiol2008-05-19T00:00:002008Gap junction remodeling in a case of arrhythmogenic right ventricular dysplasia due to plakophilin-2 mutation.2645060Hoyt RH, Cohen ML, Saffitz JECirculation researchDistribution and three-dimensional structure of intercellular junctions in canine myocardium. Circ Res. 1989 Mar; 64(3):563-74.Circ Res1989-03-01T00:00:001989Distribution and three-dimensional structure of intercellular junctions in canine myocardium.2649032Rosenbloom M, Laschinger JC, Saffitz JE, Cox JL, Bolman RMThe Annals of thoracic surgeryNoninvasive detection of cardiac allograft rejection by analysis of the unipolar peak-to-peak amplitude of intramyocardial electrograms. Ann Thorac Surg. 1989 Mar; 47(3):407-11.Ann Thorac Surg1989-03-01T00:00:001989Noninvasive detection of cardiac allograft rejection by analysis of the unipolar peak-to-peak amplitude of intramyocardial electrograms.2236562Bolman R, Saffitz JProgress in cardiovascular diseasesEarly postoperative care of the cardiac transplantation patient: routine considerations and immunosuppressive therapy. Prog Cardiovasc Dis. 1990 Nov-Dec; 33(3):137-48.Prog Cardiovasc Dis1990-11-01T00:00:001990Early postoperative care of the cardiac transplantation patient: routine considerations and immunosuppressive therapy.2022-06-30SAFFITZ, JEFFREY E2018-07-15Altered Cell-Cell Coupling in Arrhythmogenic CardiomyopathyR01HL136463Principal Investigator2965715Myears DW, Nohara R, Abendschein DR, Saffitz JE, Sobel BE, Bergmann SRJournal of the American College of CardiologyCompromise of beneficial effects of reperfusion on myocardium supplied by vessels with critical residual stenosis. J Am Coll Cardiol. 1988 May; 11(5):1078-86.J Am Coll Cardiol1988-05-01T00:00:001988Compromise of beneficial effects of reperfusion on myocardium supplied by vessels with critical residual stenosis.3098782Evers AS, Dunkel CG, Saffitz JE, Needleman PThe Journal of clinical investigationExaggerated atrial arachidonate metabolism in rabbit left ventricular myocardial infarction. J Clin Invest. 1987 Jan; 79(1):155-62.J Clin Invest1987-01-01T00:00:001987Exaggerated atrial arachidonate metabolism in rabbit left ventricular myocardial infarction.Authorship 11148313292723Eisen HJ, Rosenbloom M, Laschinger JC, Saffitz JE, Cox JL, Sobel BE, Bolman RM, Bergmann SRJournal of nuclear medicine : official publication, Society of Nuclear MedicineDetection of rejection of canine orthotopic cardiac allografts with indium-111 lymphocytes and gamma scintigraphy. J Nucl Med. 1988 Jul; 29(7):1223-9.J Nucl Med1988-07-01T00:00:001988Detection of rejection of canine orthotopic cardiac allografts with indium-111 lymphocytes and gamma scintigraphy.Authorship 10856682330067491Begay RL, Graw SL, Sinagra G, Asimaki A, Rowland TJ, Slavov DB, Gowan K, Jones KL, Brun F, Merlo M, Miani D, Sweet M, Devaraj K, Wartchow EP, Gigli M, Puggia I, Salcedo EE, Garrity DM, Ambardekar AV, Buttrick P, Reece TB, Bristow MR, Saffitz JE, Mestroni L, Taylor MRGJACC. Clinical electrophysiologyFilamin C Truncation Mutations Are Associated With Arrhythmogenic Dilated Cardiomyopathy and Changes in the Cell-Cell Adhesion Structures. JACC Clin Electrophysiol. 2018 04; 4(4):504-514.JACC Clin Electrophysiol2018-02-02T00:00:002018Filamin C Truncation Mutations Are Associated With Arrhythmogenic Dilated Cardiomyopathy and Changes in the Cell-Cell Adhesion Structures.3926781Neufeld EJ, Majerus PW, Krueger CM, Saffitz JEThe Journal of cell biologyUptake and subcellular distribution of [3H]arachidonic acid in murine fibrosarcoma cells measured by electron microscope autoradiography. J Cell Biol. 1985 Aug; 101(2):573-81.J Cell Biol1985-08-01T00:00:001985Uptake and subcellular distribution of [3H]arachidonic acid in murine fibrosarcoma cells measured by electron microscope autoradiography.7966354Kanter HL, Saffitz JE, Beyer ECJournal of molecular and cellular cardiologyMolecular cloning of two human cardiac gap junction proteins, connexin40 and connexin45. J Mol Cell Cardiol. 1994 Jul; 26(7):861-8.J Mol Cell Cardiol1994-07-01T00:00:001994Molecular cloning of two human cardiac gap junction proteins, connexin40 and connexin45.8542077Davis LM, Rodefeld ME, Green K, Beyer EC, Saffitz JEJournal of cardiovascular electrophysiologyGap junction protein phenotypes of the human heart and conduction system. J Cardiovasc Electrophysiol. 1995 Oct; 6(10 Pt 1):813-22.J Cardiovasc Electrophysiol1995-10-01T00:00:001995Gap junction protein phenotypes of the human heart and conduction system.8582296Soudais C, Bielinska M, Heikinheimo M, MacArthur CA, Narita N, Saffitz JE, Simon MC, Leiden JM, Wilson DBDevelopment (Cambridge, England)Targeted mutagenesis of the transcription factor GATA-4 gene in mouse embryonic stem cells disrupts visceral endoderm differentiation in vitro. Development. 1995 Nov; 121(11):3877-88.Development1995-11-01T00:00:001995Targeted mutagenesis of the transcription factor GATA-4 gene in mouse embryonic stem cells disrupts visceral endoderm differentiation in vitro.2478314Luke RA, Beyer EC, Hoyt RH, Saffitz JECirculation researchQuantitative analysis of intercellular connections by immunohistochemistry of the cardiac gap junction protein connexin43. Circ Res. 1989 Nov; 65(5):1450-7.Circ Res1989-11-01T00:00:001989Quantitative analysis of intercellular connections by immunohistochemistry of the cardiac gap junction protein connexin43.7541293Recchia D, Abendschein DR, Saffitz JE, Wickline SAArteriosclerosis, thrombosis, and vascular biologyThe biologic behavior of balloon hyperinflation-induced arterial lesions in hypercholesterolemic pigs depends on the presence of foam cells. Arterioscler Thromb Vasc Biol. 1995 Jul; 15(7):924-9.Arterioscler Thromb Vasc Biol1995-07-01T00:00:001995The biologic behavior of balloon hyperinflation-induced arterial lesions in hypercholesterolemic pigs depends on the presence of foam cells.8119495Saffitz JE, Nash JA, Green KG, Luke RA, Ransnas LA, Insel PAFASEB journal : official publication of the Federation of American Societies for Experimental BiologyImmunoelectron microscopic identification of cytoplasmic and nuclear Gs alpha in S49 lymphoma cells. FASEB J. 1994 Feb; 8(2):252-8.FASEB J1994-02-01T00:00:001994Immunoelectron microscopic identification of cytoplasmic and nuclear Gs alpha in S49 lymphoma cells.2546188Freed MS, Spaethe SM, Lefkowith JB, Saffitz JE, Needleman PProstaglandinsEssential fatty acid deficiency inhibits early but not late leukocyte infiltration in rabbit myocardial infarcts. 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Heart Rhythm. 2013 Feb; 10(2):283-9.Heart Rhythm2012-10-18T00:00:002012End stage of arrhythmogenic cardiomyopathy with severe involvement of the interventricular septum.6219571Saffitz JE, Rose TE, Oaks JB, Roberts WCThe American journal of cardiologyCoronary arterial rupture during coronary angioplasty. Am J Cardiol. 1983 Mar 01; 51(5):902-4.Am J Cardiol1983-03-01T00:00:001983Coronary arterial rupture during coronary angioplasty.6736460Pérez JE, Barzilai B, Madaras EI, Glueck RM, Saffitz JE, Johnston P, Miller JG, Sobel BEJournal of the American College of CardiologyApplicability of ultrasonic tissue characterization for longitudinal assessment and differentiation of calcification and fibrosis in cardiomyopathy. J Am Coll Cardiol. 1984 Jul; 4(1):88-95.J Am Coll Cardiol1984-07-01T00:00:001984Applicability of ultrasonic tissue characterization for longitudinal assessment and differentiation of calcification and fibrosis in cardiomyopathy.2764148Cohen ML, Hoyt RH, Saffitz JE, Corr PBThe American journal of physiologyA high density in vitro extracellular electrode array: description and implementation. Am J Physiol. 1989 Aug; 257(2 Pt 2):H681-9.Am J Physiol1989-08-01T00:00:001989A high density in vitro extracellular electrode array: description and implementation.21239275Saffitz JE, Hoyt RH, Luke RA, Lee Kanter H, Beyer ECTrends in cardiovascular medicineCardiac myocyte interconnections at gap junctions Role in normal and abnormal electrical conduction. 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Circ Res. 1983 Apr; 52(4):423-31.Circ Res1983-04-01T00:00:001983Coronary artery spasm in intact dogs induced by potassium and serotonin.8167131Canter CE, Moorhead S, Saffitz JE, Huddleston CB, Spray TLThe Journal of heart and lung transplantation : the official publication of the International Society for Heart TransplantationSteroid withdrawal in the pediatric heart transplant recipient initially treated with triple immunosuppression. J Heart Lung Transplant. 1994 Jan-Feb; 13(1 Pt 1):74-9; discussion 79-80.J Heart Lung Transplant1994-01-01T00:00:001994Steroid withdrawal in the pediatric heart transplant recipient initially treated with triple immunosuppression.8465791Canter CE, Saffitz JE, Moorhead S, Gutierrez FR, Bolman RM, Spray TLThe American journal of cardiologyEarly results after pediatric cardiac transplantation with triple immunosuppression therapy. Am J Cardiol. 1993 Apr 15; 71(11):971-5.Am J Cardiol1993-04-15T00:00:001993Early results after pediatric cardiac transplantation with triple immunosuppression therapy.15485443Saffitz JE, Schuessler RBJournal of cardiovascular electrophysiologyAltered atrial structure begets atrial fibrillation, but how? J Cardiovasc Electrophysiol. 2004 Oct; 15(10):1175-6.J Cardiovasc Electrophysiol2004-10-01T00:00:002004Altered atrial structure begets atrial fibrillation, but how?16389527Tang D, Yang C, Zheng J, Woodard PK, Saffitz JE, Petruccelli JD, Sicard GA, Yuan CAnnals of biomedical engineeringLocal maximal stress hypothesis and computational plaque vulnerability index for atherosclerotic plaque assessment. 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J Clin Invest. 1997 Apr 15; 99(8):1991-8.J Clin Invest1997-04-15T00:00:001997Slow ventricular conduction in mice heterozygous for a connexin43 null mutation.7240719Saffitz JE, Gross RW, Williamson JR, Sobel BEThe journal of histochemistry and cytochemistry : official journal of the Histochemistry SocietyAutoradiography of phosphatidyl choline. J Histochem Cytochem. 1981 Mar; 29(3):371-8.J Histochem Cytochem1981-03-01T00:00:001981Autoradiography of phosphatidyl choline.7634465Ohnishi Y, Butterfield MC, Saffitz JE, Sobel BE, Corr PB, Goldstein JACirculationDeleterious effects of a systemic lytic state on reperfused myocardium. Minimization of reperfusion injury and enhanced recovery of myocardial function by direct angioplasty. Circulation. 1995 Aug 01; 92(3):500-10.Circulation1995-08-01T00:00:001995Deleterious effects of a systemic lytic state on reperfused myocardium. 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Cardiol Clin. 1987 Feb; 5(1):21-30.Cardiol Clin1987-02-01T00:00:001987Coronary atherosclerosis and thrombosis underlying acute myocardial infarction.3984844Kurnik PB, Saffitz JE, Ahumada GG, Tiefenbrunn AJ, Spadaro JJ, Ludbrook PAAmerican heart journal19-year longevity of isolated tricuspid valve replacement. Am Heart J. 1985 Apr; 109(4):904-5.Am Heart J1985-04-01T00:00:00198519-year longevity of isolated tricuspid valve replacement.6458065Saffitz JE, Totty WG, McClennan BL, Gilula LARadiologyPercutaneous transluminal angioplasty. Radiological-pathological correlation. Radiology. 1981 Dec; 141(3):651-4.Radiology1981-12-01T00:00:001981Percutaneous transluminal angioplasty. Radiological-pathological correlation.7083488Gross RW, Corr PB, Lee BI, Saffitz JE, Crafford WA, Sobel BECirculation researchIncorporation of radiolabeled lysophosphatidyl choline into canine Purkinje fibers and ventricular muscle. Electrophysiological, biochemical, and autoradiographic correlations. 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Ann Thorac Surg. 1994 Jan; 57(1):203-7.Ann Thorac Surg1994-01-01T00:00:001994Potential ablation of accessory atrioventricular pathways: injection of alcohol into the atrioventricular groove.8520538Beyer EC, Davis LM, Saffitz JE, Veenstra RDBrazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicasCardiac intercellular communication: consequences of connexin distribution and diversity. Braz J Med Biol Res. 1995 Apr; 28(4):415-25.Braz J Med Biol Res1995-04-01T00:00:001995Cardiac intercellular communication: consequences of connexin distribution and diversity.2492036Freed MS, Needleman P, Dunkel CG, Saffitz JE, Evers ASThe Journal of clinical investigationRole of invading leukocytes in enhanced atrial eicosanoid production following rabbit left ventricular myocardial infarction. J Clin Invest. 1989 Jan; 83(1):205-12.J Clin Invest1989-01-01T00:00:001989Role of invading leukocytes in enhanced atrial eicosanoid production following rabbit left ventricular myocardial infarction.2541942Martin WH, Murphree SS, Saffitz JECirculation researchBeta-adrenergic receptor distribution among muscle fiber types and resistance arterioles of white, red, and intermediate skeletal muscle. Circ Res. 1989 Jun; 64(6):1096-105.Circ Res1989-06-01T00:00:001989Beta-adrenergic receptor distribution among muscle fiber types and resistance arterioles of white, red, and intermediate skeletal muscle.21073337Saffitz JEAnnual review of pathologyThe pathobiology of arrhythmogenic cardiomyopathy. Annu Rev Pathol. 2011; 6:299-321.Annu Rev Pathol2011-01-01T00:00:002011The pathobiology of arrhythmogenic cardiomyopathy.21859801Asimaki A, Tandri H, Duffy ER, Winterfield JR, Mackey-Bojack S, Picken MM, Cooper LT, Wilber DJ, Marcus FI, Basso C, Thiene G, Tsatsopoulou A, Protonotarios N, Stevenson WG, McKenna WJ, Gautam S, Remick DG, Calkins H, Saffitz JECirculation. Arrhythmia and electrophysiologyAltered desmosomal proteins in granulomatous myocarditis and potential pathogenic links to arrhythmogenic right ventricular cardiomyopathy. Circ Arrhythm Electrophysiol. 2011 Oct; 4(5):743-52.Circ Arrhythm Electrophysiol2011-08-22T00:00:002011Altered desmosomal proteins in granulomatous myocarditis and potential pathogenic links to arrhythmogenic right ventricular cardiomyopathy.2921326Corr PB, Creer MH, Yamada KA, Saffitz JE, Sobel BEThe Journal of clinical investigationProphylaxis of early ventricular fibrillation by inhibition of acylcarnitine accumulation. J Clin Invest. 1989 Mar; 83(3):927-36.J Clin Invest1989-03-01T00:00:001989Prophylaxis of early ventricular fibrillation by inhibition of acylcarnitine accumulation.Authorship 1121471130559047Saffitz JETrends in cardiovascular medicineEditorial commentary: Nuclear receptors and a network biology approach to understanding and treating heart disease. Trends Cardiovasc Med. 2019 11; 29(8):438-439.Trends Cardiovasc Med2018-12-11T00:00:002018Editorial commentary: Nuclear receptors and a network biology approach to understanding and treating heart disease.3105915Sobel BE, Saffitz JE, Fields LE, Myears DW, Sarnoff SJ, Robison AK, Owensby DA, Fox KACirculationIntramuscular administration of human tissue-type plasminogen activator in rabbits and dogs and its implications for coronary thrombolysis. Circulation. 1987 Jun; 75(6):1261-72.Circulation1987-06-01T00:00:001987Intramuscular administration of human tissue-type plasminogen activator in rabbits and dogs and its implications for coronary thrombolysis.7034991Bergmann SR, Lerch RA, Carlson EM, Saffitz JE, Sobel BECirculationDetection of cardiac transplant rejection with radiolabeled lymphocytes. Circulation. 1982 Mar; 65(3):591-9.Circulation1982-03-01T00:00:001982Detection of cardiac transplant rejection with radiolabeled lymphocytes.8051083York JD, Saffitz JE, Majerus PWThe Journal of biological chemistryInositol polyphosphate 1-phosphatase is present in the nucleus and inhibits DNA synthesis. J Biol Chem. 1994 Aug 05; 269(31):19992-9.J Biol Chem1994-08-05T00:00:001994Inositol polyphosphate 1-phosphatase is present in the nucleus and inhibits DNA synthesis.8719456Balzer DT, Moorhead S, Saffitz JE, Huddleston CB, Spray TL, Canter CEThe Journal of heart and lung transplantation : the official publication of the International Society for Heart TransplantationUtility of surveillance biopsies in infant heart transplant recipients. J Heart Lung Transplant. 1995 Nov-Dec; 14(6 Pt 1):1095-101.J Heart Lung Transplant1995-11-01T00:00:001995Utility of surveillance biopsies in infant heart transplant recipients.8930735Rodefeld MD, Beau SL, Schuessler RB, Boineau JP, Saffitz JEJournal of cardiovascular electrophysiologyBeta-adrenergic and muscarinic cholinergic receptor densities in the human sinoatrial node: identification of a high beta 2-adrenergic receptor density. J Cardiovasc Electrophysiol. 1996 Nov; 7(11):1039-49.J Cardiovasc Electrophysiol1996-11-01T00:00:001996Beta-adrenergic and muscarinic cholinergic receptor densities in the human sinoatrial node: identification of a high beta 2-adrenergic receptor density.11029400Beardslee MA, Lerner DL, Tadros PN, Laing JG, Beyer EC, Yamada KA, Kléber AG, Schuessler RB, Saffitz JECirculation researchDephosphorylation and intracellular redistribution of ventricular connexin43 during electrical uncoupling induced by ischemia. Circ Res. 2000 Oct 13; 87(8):656-62.Circ Res2000-10-13T00:00:002000Dephosphorylation and intracellular redistribution of ventricular connexin43 during electrical uncoupling induced by ischemia.1728848Saffitz JEAmerican journal of clinical pathologyToward a unified concept of vascular smooth muscle response to injury. Am J Clin Pathol. 1992 Jan; 97(1):1-3.Am J Clin Pathol1992-01-01T00:00:001992Toward a unified concept of vascular smooth muscle response to injury.Authorship 11347316344397Saffitz JECirculationStructural heart disease, SCN5A gene mutations, and Brugada syndrome: a complex ménage à trois. Circulation. 2005 Dec 13; 112(24):3672-4.Circulation2005-12-13T00:00:002005Structural heart disease, SCN5A gene mutations, and Brugada syndrome: a complex ménage à trois.16533266Saffitz JEJournal of cardiovascular electrophysiologyAdhesion molecules: why they are important to the electrophysiologist. J Cardiovasc Electrophysiol. 2006 Feb; 17(2):225-9.J Cardiovasc Electrophysiol2006-02-01T00:00:002006Adhesion molecules: why they are important to the electrophysiologist.20049974Samedi V, White S, Zimarowski MJ, Harris A, Saffitz J, Wang HHDiagnostic cytopathologyMetastatic peritoneal mesothelioma in the setting of recurrent ascites: a case report. Diagn Cytopathol. 2010 Sep; 38(9):675-81.Diagn Cytopathol2010-09-01T00:00:002010Metastatic peritoneal mesothelioma in the setting of recurrent ascites: a case report.2643398Bolman RM, Cox JL, Marshall W, Kouchoukos N, Spray TL, Cance C, Genton RE, Saffitz JThe Annals of thoracic surgeryCirculatory support with a centrifugal pump as a bridge to cardiac transplantation. Ann Thorac Surg. 1989 Jan; 47(1):108-12.Ann Thorac Surg1989-01-01T00:00:001989Circulatory support with a centrifugal pump as a bridge to cardiac transplantation.20472839Haspel RL, Arnaout R, Briere L, Kantarci S, Marchand K, Tonellato P, Connolly J, Boguski MS, Saffitz JEAmerican journal of clinical pathologyA call to action: training pathology residents in genomics and personalized medicine. Am J Clin Pathol. 2010 Jun; 133(6):832-4.Am J Clin Pathol2010-06-01T00:00:002010A call to action: training pathology residents in genomics and personalized medicine.Authorship 1127435230664373Thiene G, Saffitz JECirculationResponse by Thiene and Saffitz to Letter Regarding Article, "Autopsy as a Source of Discovery in Cardiovascular Medicine: Then and Now". Circulation. 2019 01 22; 139(4):568-569.Circulation2019-01-22T00:00:002019Response by Thiene and Saffitz to Letter Regarding Article, "Autopsy as a Source of Discovery in Cardiovascular Medicine: Then and Now".3321629Pikul FJ, Bolman RM, Saffitz JE, Chaplin HTransplantation proceedingsAnti-B-mediated rejection of an ABO-incompatible cardiac allograft despite aggressive plasma exchange transfusion. Transplant Proc. 1987 Dec; 19(6):4601-4.Transplant Proc1987-12-01T00:00:001987Anti-B-mediated rejection of an ABO-incompatible cardiac allograft despite aggressive plasma exchange transfusion.6682618Saffitz JE, McIntosh CL, Roberts WCThe American journal of cardiologyMassive right ventricular outflow tract aneurysm after ventriculotomy for subvalvular pulmonic stenosis associated with peripheral pulmonary arterial stenoses. Am J Cardiol. 1983 May 01; 51(8):1460-2.Am J Cardiol1983-05-01T00:00:001983Massive right ventricular outflow tract aneurysm after ventriculotomy for subvalvular pulmonic stenosis associated with peripheral pulmonary arterial stenoses.Authorship 1131521930763825Te Rijdt WP, Asimaki A, Jongbloed JDH, Hoorntje ET, Lazzarini E, van der Zwaag PA, de Boer RA, van Tintelen JP, Saffitz JE, van den Berg MP, Suurmeijer AJHCardiovascular pathology : the official journal of the Society for Cardiovascular PathologyDistinct molecular signature of phospholamban p.Arg14del arrhythmogenic cardiomyopathy. Cardiovasc Pathol. 2019 May - Jun; 40:2-6.Cardiovasc Pathol2018-12-21T00:00:002018Distinct molecular signature of phospholamban p.Arg14del arrhythmogenic cardiomyopathy.Authorship 118743Authorship 12232820D001145Disorders74122650.473847Arrhythmias, CardiacD019571Disorders621610.854485Arrhythmogenic Right Ventricular DysplasiaD009206Anatomy132247880.381446MyocardiumD018031Chemicals & Drugs1052060.895435Connexin 43Authorship 1238256Authorship 1246665Authorship 1149461531028357Austin KM, Trembley MA, Chandler SF, Sanders SP, Saffitz JE, Abrams DJ, Pu WTNature reviews. CardiologyMolecular mechanisms of arrhythmogenic cardiomyopathy. Nat Rev Cardiol. 2019 09; 16(9):519-537.Nat Rev Cardiol2019-09-01T00:00:002019Molecular mechanisms of arrhythmogenic cardiomyopathy.D017629Anatomy922330.860175Gap JunctionsAuthorship 1228214EmeritusMedicineNeurobiologyPathologyPediatricsCardiologyInternal MedicineBeth Israel Deaconess Medical CenterBrigham and Women's HospitalBoston Children's HospitalHarvard Medical SchoolMassachusetts General HospitalAR5AnthonyRosenzweigAnthony Rosenzweig, M.D.42.34022770000000-71.1058540000000010161Rosenzweig, AnthonyEvelyn and James Jenks and Paul Dudley White Professor of Medicine in the Field of Cardiology, EmeritusAT14AlexTokerAlex Toker, Ph.D.42.34022770000000-71.1058540000000084340Toker, AlexProfessor of PathologyAuthorship 11523442531078652Towbin JA, McKenna WJ, Abrams DJ, Ackerman MJ, Calkins H, Darrieux FCC, Daubert JP, de Chillou C, DePasquale EC, Desai MY, Estes NAM, Hua W, Indik JH, Ingles J, James CA, John RM, Judge DP, Keegan R, Krahn AD, Link MS, Marcus FI, McLeod CJ, Mestroni L, Priori SG, Saffitz JE, Sanatani S, Shimizu W, van Tintelen JP, Wilde AAM, Zareba WHeart rhythm2019 HRS expert consensus statement on evaluation, risk stratification, and management of arrhythmogenic cardiomyopathy. Heart Rhythm. 2019 11; 16(11):e301-e372.Heart Rhythm2019-05-09T00:00:0020192019 HRS expert consensus statement on evaluation, risk stratification, and management of arrhythmogenic cardiomyopathy.SDS3ScottSolomonScott David Solomon, M.D.42.33510370000000-71.1061649000000037443Solomon, ScottProfessor of MedicineAuthorship 1248154WTP2WilliamPuWilliam T. Pu, M.D.42.33743600000000-71.105447000000001355Pu, WilliamAldo R. Castaneda Professor of Pediatrics in the Field of Cardiovascular ResearchCAM9CalumMacRaeCalum Archibald MacRae, M.D., Ph.D.42.33510370000000-71.106164900000008426MacRae, CalumProfessor of Medicine11313selected publications7.863320.000980369960research areas0.8757880.024406324coauthor of71.328719.837960similar toRLV1RichardVerrierRichard Leonard Verrier, Ph.D.42.34620670000000-71.0997834000000080524Verrier, RichardCorresponding Member of the Faculty of MedicineJLH2JonathanHechtJonathan Lewis Hecht, M.D., Ph.D.42.34022770000000-71.10585400000000349Hecht, JonathanProfessor of PathologyDLP1DavidPaulDavid L. Paul, Ph.D.42.33602040000000-71.103432500000003991Paul, DavidProfessor of NeurobiologyJLC4JamesConnollyJames Leo Connolly, M.D.42.34022770000000-71.1058540000000057030Connolly, JamesProfessor of PathologyYS51YueSunYue Sun, M.D.42.34022770000000-71.1058540000000026846Sun, YueAssistant Professor of PathologyCES5ChristineSeidmanChristine Edry Seidman, M.D.42.33837200000000-71.1032690000000029608Seidman, ChristineThomas W. Smith Professor of MedicineGP18GermanPihanGerman Pihan, M.D.42.34022770000000-71.1058540000000086543Pihan, GermanAssistant Professor of PathologyRLH3RichardHaspelRichard Lawrence Haspel, M.D., Ph.D.42.34022770000000-71.1058540000000084808Haspel, RichardProfessor of PathologySPS20StephenSandersStephen Pruett Sanders, M.D.93699Sanders, StephenProfessor of Pediatrics, Part-timeAuthorship 1317596Authorship 1170361Authorship 1186198631439293Barkagan M, Leshem E, Shapira-Daniels A, Sroubek J, Buxton AE, Saffitz JE, Anter EJACC. Clinical electrophysiologyHistopathological Characterization of Radiofrequency Ablation in Ventricular Scar Tissue. JACC Clin Electrophysiol. 2019 08; 5(8):920-931.JACC Clin Electrophysiol2019-06-26T00:00:002019Histopathological Characterization of Radiofrequency Ablation in Ventricular Scar Tissue.Authorship 14601210Authorship 11893941131533459Chelko SP, Asimaki A, Lowenthal J, Bueno-Beti C, Bedja D, Scalco A, Amat-Alarcon N, Andersen P, Judge DP, Tung L, Saffitz JECirculationTherapeutic Modulation of the Immune Response in Arrhythmogenic Cardiomyopathy. Circulation. 2019 10 29; 140(18):1491-1505.Circulation2019-09-19T00:00:002019Therapeutic Modulation of the Immune Response in Arrhythmogenic Cardiomyopathy.Authorship 1541159Authorship 12007082531676023Towbin JA, McKenna WJ, Abrams DJ, Ackerman MJ, Calkins H, Darrieux FCC, Daubert JP, de Chillou C, DePasquale EC, Desai MY, Estes NAM, Hua W, Indik JH, Ingles J, James CA, John RM, Judge DP, Keegan R, Krahn AD, Link MS, Marcus FI, McLeod CJ, Mestroni L, Priori SG, Saffitz JE, Sanatani S, Shimizu W, van Tintelen JP, Wilde AAM, Zareba WHeart rhythm2019 HRS expert consensus statement on evaluation, risk stratification, and management of arrhythmogenic cardiomyopathy: Executive summary. Heart Rhythm. 2019 11; 16(11):e373-e407.Heart Rhythm2019-11-01T00:00:0020192019 HRS expert consensus statement on evaluation, risk stratification, and management of arrhythmogenic cardiomyopathy: Executive summary.Authorship 13380514true1Professor of PathologyProfessor of Pathologytrue1Professor of NeurobiologyProfessor of Neurobiologytrue1Professor of MedicineProfessor of Medicinetrue1Assistant Professor of PathologyAssistant Professor of Pathologytrue1Professor of PathologyProfessor of PathologyAuthorship 1240382Authorship 146404Authorship 1329421true1Professor of MedicineProfessor of MedicineAuthorship 1178325Authorship 1201055Authorship 1621611Authorship 1234312432164419Camors EM, Purevjav E, Jefferies JL, Saffitz JE, Gong N, Ryan TD, Lucky AW, Taylor MD, Sullivan LM, Mestroni L, Towbin JACirculation. Genomic and precision medicineEarly Lethality Due to a Novel Desmoplakin Variant Causing Infantile Epidermolysis Bullosa Simplex With Fragile Skin, Aplasia Cutis Congenita, and Arrhythmogenic Cardiomyopathy. Circ Genom Precis Med. 2020 04; 13(2):e002800.Circ Genom Precis Med2020-03-12T00:00:002020Early Lethality Due to a Novel Desmoplakin Variant Causing Infantile Epidermolysis Bullosa Simplex With Fragile Skin, Aplasia Cutis Congenita, and Arrhythmogenic Cardiomyopathy.Authorship 1818671Authorship 176562024-03-31SAFFITZ, JEFFREY E2020-04-01Arrhythmogenic Cardiomyopathy is an Inflammatory DiseaseR01HL148348Principal InvestigatorAuthorship 1746671Authorship 18045415Authorship 12472691532418505Lerchenmüller C, Rabolli CP, Yeri A, Kitchen R, Salvador AM, Liu LX, Ziegler O, Danielson K, Platt C, Shah R, Damilano F, Kundu P, Riechert E, Katus HA, Saffitz JE, Keshishian H, Carr SA, Bezzerides VJ, Das S, Rosenzweig ACirculation researchCITED4 Protects Against Adverse Remodeling in Response to Physiological and Pathological Stress. Circ Res. 2020 08 14; 127(5):631-646.Circ Res2020-05-18T00:00:002020CITED4 Protects Against Adverse Remodeling in Response to Physiological and Pathological Stress.Authorship 1402436Authorship 135282Authorship 1391973Authorship 1487235Authorship 1472528Authorship 1653323Authorship 1268338232654517Corradi D, Saffitz JE, Novelli D, Asimaki A, Simon C, Oldoni E, Masson S, Meessen JMTA, Monaco R, Manuguerra R, Latini R, Libby P, Tavazzi L, Marchioli R, Dozza L, Cavallotti L, Aleksova A, Gregorini R, Mozaffarian DCirculation. Arrhythmia and electrophysiologyProspective Evaluation of Clinico-Pathological Predictors of Postoperative Atrial Fibrillation: An Ancillary Study From the OPERA Trial. Circ Arrhythm Electrophysiol. 2020 08; 13(8):e008382.Circ Arrhythm Electrophysiol2020-07-12T00:00:002020Prospective Evaluation of Clinico-Pathological Predictors of Postoperative Atrial Fibrillation: An Ancillary Study From the OPERA Trial.Authorship 1613752Authorship 1635563Authorship 1819402Authorship 18333Authorship 1851653Authorship 2241411Authorship 192384432091412Shaw RM, Saffitz JEThe Journal of clinical investigationA role for connexin-43 in Duchenne muscular dystrophy cardiomyopathy. J Clin Invest. 2020 04 01; 130(4):1608-1610.J Clin Invest2020-04-01T00:00:002020A role for connexin-43 in Duchenne muscular dystrophy cardiomyopathy.Authorship 13116052Authorship 198671Authorship 13312432033597260Chelko SP, Keceli G, Carpi A, Doti N, Agrimi J, Asimaki A, Beti CB, Miyamoto M, Amat-Codina N, Bedja D, Wei AC, Murray B, Tichnell C, Kwon C, Calkins H, James CA, O'Rourke B, Halushka MK, Melloni E, Saffitz JE, Judge DP, Ruvo M, Kitsis RN, Andersen P, Di Lisa F, Paolocci NScience translational medicineExercise triggers CAPN1-mediated AIF truncation, inducing myocyte cell death in arrhythmogenic cardiomyopathy. Sci Transl Med. 2021 02 17; 13(581).Sci Transl Med2021-02-17T00:00:002021Exercise triggers CAPN1-mediated AIF truncation, inducing myocyte cell death in arrhythmogenic cardiomyopathy.Authorship 1350899233905812Chelko SP, Saffitz JEHeart rhythmRole of galectin-3 in the pathogenesis of arrhythmogenic cardiomyopathy-It's complicated. Heart Rhythm. 2021 08; 18(8):1404-1405.Heart Rhythm2021-04-24T00:00:002021Role of galectin-3 in the pathogenesis of arrhythmogenic cardiomyopathy-It's complicated.Authorship 2541244Authorship 1746711Authorship 1377000834300226Hawthorne RN, Blazeski A, Lowenthal J, Kannan S, Teuben R, DiSilvestre D, Morrissette-McAlmon J, Saffitz JE, Boheler KR, James CA, Chelko SP, Tomaselli G, Tung LJournal of clinical medicineAltered Electrical, Biomolecular, and Immunologic Phenotypes in a Novel Patient-Derived Stem Cell Model of Desmoglein-2 Mutant ARVC. J Clin Med. 2021 Jul 10; 10(14).J Clin Med2021-07-10T00:00:002021Altered Electrical, Biomolecular, and Immunologic Phenotypes in a Novel Patient-Derived Stem Cell Model of Desmoglein-2 Mutant ARVC.true1Professor of PathologyProfessor of PathologyAuthorship 2213001Authorship 2239284Authorship 1442464735300203Bueno-Beti C, Field E, Tsatsopoulou A, Perry G, Sheppard MN, Behr ER, Saffitz JE, Kaski JP, Asimaki AProgress in pediatric cardiologyAnalysis of buccal mucosa as a prognostic tool in children with arrhythmogenic cardiomyopathy. Prog Pediatr Cardiol. 2022 Mar; 64:None.Prog Pediatr Cardiol2022-03-01T00:00:002022Analysis of buccal mucosa as a prognostic tool in children with arrhythmogenic cardiomyopathy.Authorship 2769194Authorship 2932461Authorship 3453785Authorship 166192true1Assistant Professor of PathologyAssistant Professor of PathologyAuthorship 2470792Authorship 1526778636807418Thiene G, Buja G, Bauce B, Corrado D, Basso C, Saffitz JEuropean heart journalObituary for Frank Marcus, outstanding medical scientist of right ventricular dysplasia/cardiomyopathy. Eur Heart J. 2023 Feb 18.Eur Heart J2023-02-18T00:00:002023Obituary for Frank Marcus, outstanding medical scientist of right ventricular dysplasia/cardiomyopathy.Authorship 1724537Authorship 176943Authorship 1532899936927183Palatinus JA, Valdez S, Taylor L, Whisenant C, Selzman CH, Drakos SG, Ranjan R, Hong T, Saffitz JE, Shaw RMCirculation researchGJA1-20k Rescues Cx43 Localization and Arrhythmias in Arrhythmogenic Cardiomyopathy. Circ Res. 2023 03 17; 132(6):744-746.Circ Res2023-02-22T00:00:002023GJA1-20k Rescues Cx43 Localization and Arrhythmias in Arrhythmogenic Cardiomyopathy.Authorship 2061175Authorship 5002443true1Evelyn and James Jenks and Paul Dudley White Professor of Medicine in the Field of Cardiology, EmeritusEvelyn and James Jenks and Paul Dudley White Professor of Medicine in the Field of Cardiology, EmeritusAuthorship 27469617Authorship 1571349737503283Chelko SP, Penna V, Engel M, Landim-Vieira M, Cannon EN, Lavine K, Saffitz JEbioRxiv : the preprint server for biologyMechanisms of Innate Immune Injury in Arrhythmogenic Cardiomyopathy. bioRxiv. 2023 Jul 13.bioRxiv2023-07-13T00:00:002023Mechanisms of Innate Immune Injury in Arrhythmogenic Cardiomyopathy.Authorship 2874879Authorship 3134615jul314JustinLowenthalJustin Isaac Lowenthal, M.D.,Ph.D.216725Lowenthal, JustinClinical Fellow in MedicineAuthorship 3483313Authorship 15906411237649905Bueto-Beni C, Tafuni A, Chelko SP, Sheppard MN, Field E, Tollit J, Heenan IK, Barnes A, Taylor MR, Mestroni L, Kaski JP, Saffitz JE, Asimaki AbioRxiv : the preprint server for biologyInnate Immune Signaling in Hearts and Buccal Mucosa Cells of Patients with Arrhythmogenic Cardiomyopathy. bioRxiv. 2023 Jul 27.bioRxiv2023-07-27T00:00:002023Innate Immune Signaling in Hearts and Buccal Mucosa Cells of Patients with Arrhythmogenic Cardiomyopathy.Authorship 3809084true1Thomas W. Smith Professor of MedicineThomas W. Smith Professor of Medicinetrue1Clinical Fellow in MedicineClinical Fellow in Medicinetrue1Professor of PathologyProfessor of PathologyAuthorship 414472Authorship 16053031237936669Bueno-Beti C, Tafuni A, Chelko SP, Sheppard MN, Field E, Tollit J, Heenan IK, Barnes A, Taylor MR, Mestroni L, Kaski JP, Saffitz JE, Asimaki AHeart rhythm O2Innate immune signaling in hearts and buccal mucosa cells of patients with arrhythmogenic cardiomyopathy. Heart Rhythm O2. 2023 Oct; 4(10):650-659.Heart Rhythm O22023-09-19T00:00:002023Innate immune signaling in hearts and buccal mucosa cells of patients with arrhythmogenic cardiomyopathy.Authorship 16099191037956903Jin Q, Lee KY, Selimi Z, Shimura D, Wang E, Zimmerman JF, Shaw RM, Kucera JP, Parker KK, Saffitz JE, Kleber AGJournal of molecular and cellular cardiologyDeterminants of electrical propagation and propagation block in Arrhythmogenic Cardiomyopathy. J Mol Cell Cardiol. 2024 Jan; 186:71-80.J Mol Cell Cardiol2023-11-11T00:00:002023Determinants of electrical propagation and propagation block in Arrhythmogenic Cardiomyopathy.38113321Namasivayam M, Bertrand PB, Bernard S, Churchill TW, Khurshid S, Marcus FI, Mestroni L, Saffitz JE, Towbin JA, Zareba W, Picard MH, Sanborn DYCirculation. Cardiovascular imagingUtility of Left and Right Ventricular Strain in Arrhythmogenic Right Ventricular Cardiomyopathy: A Prospective Multicenter Registry. Circ Cardiovasc Imaging. 2023 Dec; 16(12):e015671.Circ Cardiovasc Imaging2023-12-19T00:00:002023Utility of Left and Right Ventricular Strain in Arrhythmogenic Right Ventricular Cardiomyopathy: A Prospective Multicenter Registry.Authorship 16144208Authorship 5299852Head of the Department of Pathology at Beth Israel Deaconess Medical CenterHead of the Department of Pathology at Beth Israel Deaconess Medical Centertrue1Mallinckrodt Professor of PathologyMallinckrodt Professor of Pathology3Professor of PathologyProfessor of Pathologytrue1Corresponding Member of the Faculty of MedicineCorresponding Member of the Faculty of MedicineAuthorship 171307Authorship 5330972true1Professor of Pediatrics, Part-timeProfessor of Pediatrics, Part-timetrue1Aldo R. Castaneda Professor of Pediatrics in the Field of Cardiovascular ResearchAldo R. Castaneda Professor of Pediatrics in the Field of Cardiovascular ResearchAuthorship 5548751Authorship 555874Authorship 420537Authorship 24369718Authorship 3213222Authorship 647929323674817Park JK, Rosen A, Saffitz JE, Asimaki A, Litovsky SH, Mackey-Bojack SM, Halushka MKRheumatology (Oxford, England)Expression of cathepsin K and tartrate-resistant acid phosphatase is not confined to osteoclasts but is a general feature of multinucleated giant cells: systematic analysis. Rheumatology (Oxford). 2013 Aug; 52(8):1529-33.Rheumatology (Oxford)2013-05-14T00:00:002013Expression of cathepsin K and tartrate-resistant acid phosphatase is not confined to osteoclasts but is a general feature of multinucleated giant cells: systematic analysis.Authorship 714821Authorship 5525684Authorship 885937Authorship 2277523Authorship 6733441023688911Noorman M, Hakim S, Asimaki A, Vreeker A, van Rijen HV, van der Heyden MA, de Jonge N, de Weger RA, Hauer RN, Saffitz JE, van Veen TACardiovascular pathology : the official journal of the Society for Cardiovascular PathologyReduced plakoglobin immunoreactivity in arrhythmogenic cardiomyopathy: methodological considerations. Cardiovasc Pathol. 2013 Sep-Oct; 22(5):314-8.Cardiovasc Pathol2013-05-17T00:00:002013Reduced plakoglobin immunoreactivity in arrhythmogenic cardiomyopathy: methodological considerations.Authorship 2545606Authorship 2541088Authorship 3178793Authorship 3700014Authorship 3764713Authorship 1792405Authorship 3797983Authorship 38701113Authorship 1853181Authorship 703843224445771Haspel RL, Saffitz JECancer journal (Sudbury, Mass.)Genomic oncology education: an urgent need, a new approach. Cancer J. 2014 Jan-Feb; 20(1):91-5.Cancer J2014-01-01T00:00:002014Genomic oncology education: an urgent need, a new approach.Authorship 2569153Authorship 2660331Authorship 2640454Authorship 276381Authorship 3860306Authorship 2856093Authorship 1973771Authorship 2945302Authorship 3092941Authorship 3348128Authorship 719548224460198Asimaki A, Saffitz JECell communication & adhesionRemodeling of cell-cell junctions in arrhythmogenic cardiomyopathy. Cell Commun Adhes. 2014 Feb; 21(1):13-23.Cell Commun Adhes2014-02-01T00:00:002014Remodeling of cell-cell junctions in arrhythmogenic cardiomyopathy.Authorship 329663Authorship 2707776Authorship 2778861Authorship 2319171Authorship 3405264Authorship 3434914Authorship 729969124647276Saffitz JE, Sanders SPCirculationPostmortem analysis of structural heart defects in fetuses and children by magnetic resonance imaging: an alternative to autopsy? Circulation. 2014 May 13; 129(19):1909-11.Circulation2014-03-19T00:00:002014Postmortem analysis of structural heart defects in fetuses and children by magnetic resonance imaging: an alternative to autopsy?Authorship 7347681424920660Asimaki A, Kapoor S, Plovie E, Karin Arndt A, Adams E, Liu Z, James CA, Judge DP, Calkins H, Churko J, Wu JC, MacRae CA, Kléber AG, Saffitz JEScience translational medicineIdentification of a new modulator of the intercalated disc in a zebrafish model of arrhythmogenic cardiomyopathy. Sci Transl Med. 2014 Jun 11; 6(240):240ra74.Sci Transl Med2014-06-11T00:00:002014Identification of a new modulator of the intercalated disc in a zebrafish model of arrhythmogenic cardiomyopathy.Authorship 2801475Authorship 2858331Authorship 1646903Authorship 3154504Authorship 7379851524560692Corradi D, Callegari S, Manotti L, Ferrara D, Goldoni M, Alinovi R, Pinelli S, Mozzoni P, Andreoli R, Asimaki A, Pozzoli A, Becchi G, Mutti A, Benussi S, Saffitz JE, Alfieri OHeart rhythmPersistent lone atrial fibrillation: clinicopathologic study of 19 cases. Heart Rhythm. 2014 Jul; 11(7):1250-8.Heart Rhythm2014-02-18T00:00:002014Persistent lone atrial fibrillation: clinicopathologic study of 19 cases.Authorship 2956901Authorship 3305763Authorship 375061Authorship 3778943Authorship 3977343Authorship 39821412Authorship 4236667Authorship 3447792Authorship 5002733Authorship 5663785Authorship 4172725Authorship 4312134Authorship 4563223Authorship 7679966Authorship 767610225253076Hariharan V, Asimaki A, Michaelson JE, Plovie E, MacRae CA, Saffitz JE, Huang HCardiovascular researchArrhythmogenic right ventricular cardiomyopathy mutations alter shear response without changes in cell-cell adhesion. Cardiovasc Res. 2014 Nov 01; 104(2):280-9.Cardiovasc Res2014-09-24T00:00:002014Arrhythmogenic right ventricular cardiomyopathy mutations alter shear response without changes in cell-cell adhesion.25368581Kleber AG, Saffitz JEFrontiers in physiologyRole of the intercalated disc in cardiac propagation and arrhythmogenesis. Front Physiol. 2014; 5:404.Front Physiol2014-10-17T00:00:002014Role of the intercalated disc in cardiac propagation and arrhythmogenesis.Authorship 4197142Authorship 2247364Authorship 3615931Authorship 4974701Authorship 446312Authorship 4473110Authorship 4678171Authorship 469822Authorship 5433571Authorship 612871Authorship 693001Authorship 907903Authorship 3116031Authorship 3219462Authorship 405234Authorship 3793042Authorship 3952161Authorship 4093413Authorship 418277Authorship 4208378Authorship 4401211Authorship 2985525Authorship 4519283Authorship 21987313Authorship 516165Authorship 3672463Authorship 5237207Authorship 3777704Authorship 5284772Authorship 3836732Authorship 5382666Authorship 5460021Authorship 436614Authorship 4392174Authorship 993944Authorship 2900652Authorship 4708611Authorship 4803021Authorship 4940901Authorship 5051225Authorship 5071674Authorship 538517Authorship 5625771Authorship 949210Authorship 883824Authorship 3017175Authorship 313633Authorship 2425823Authorship 2067881Authorship 2070528Authorship 4135522Authorship 2522122Authorship 2645853Authorship 2862283Authorship 2740083Authorship 306232Authorship 308124Authorship 3443756Authorship 3605483Authorship 4057571Authorship 4269995Authorship 469421Authorship 4705091Authorship 541355Authorship 5420753Authorship 563713Authorship 5749275Authorship 654396Authorship 2518402Authorship 2563873Authorship 268072Authorship 3094954Authorship 3279797Authorship 3282991Authorship 3672041Authorship 3772195Authorship 4183133Authorship 1402277Authorship 141257Authorship 2263682Authorship 2499574Authorship 2948764Authorship 3034947Authorship 3342014Authorship 3384361Authorship 41547912Authorship 5395435Authorship 5461553Authorship 5659064Authorship 1648366Authorship 2720165Authorship 3284773Authorship 385951Authorship 3974765Authorship 5051461Authorship 55098819Authorship 795284125990853Saffitz JECardiovascular pathology : the official journal of the Society for Cardiovascular PathologyMyocyte interconnections at gap junctions and the development of anatomic substrates of ventricular arrhythmia's. Cardiovasc Pathol. 1994 Apr-Jun; 3(2):87-91.Cardiovasc Pathol1994-04-01T00:00:001994Myocyte interconnections at gap junctions and the development of anatomic substrates of ventricular arrhythmia's.Authorship 688883Authorship 808061Authorship 880811Authorship 2505004Authorship 2829774Authorship 3050482Authorship 32769617Authorship 4667949Authorship 5410962Authorship 3791742Authorship 811841125666491Saffitz JETrends in cardiovascular medicineProtein trafficking in cardiovascular disease: How the science has evolved and where it must go. Trends Cardiovasc Med. 2015 Jul; 25(5):390-1.Trends Cardiovasc Med2015-01-12T00:00:002015Protein trafficking in cardiovascular disease: How the science has evolved and where it must go.Authorship 2943295Authorship 2976781Authorship 2965841Authorship 816914325251156Ahmad T, Yin P, Saffitz J, Pockros PJ, Lalezari J, Shiffman M, Freilich B, Zamparo J, Brown K, Dimitrova D, Kumar M, Manion D, Heath-Chiozzi M, Wolf R, Hughes E, Muir AJ, Hernandez AFHepatology (Baltimore, Md.)Cardiac dysfunction associated with a nucleotide polymerase inhibitor for treatment of hepatitis C. Hepatology. 2015 Aug; 62(2):409-16.Hepatology2015-05-26T00:00:002015Cardiac dysfunction associated with a nucleotide polymerase inhibitor for treatment of hepatitis C.Authorship 4183651Authorship 460281Authorship 5406859Authorship 5434508Authorship 84370311Authorship 845663326199027Asimaki A, Kleber AG, Saffitz JEThe Canadian journal of cardiologyPathogenesis of Arrhythmogenic Cardiomyopathy. Can J Cardiol. 2015 Nov; 31(11):1313-24.Can J Cardiol2015-04-24T00:00:002015Pathogenesis of Arrhythmogenic Cardiomyopathy.26475296Spezzacatene A, Sinagra G, Merlo M, Barbati G, Graw SL, Brun F, Slavov D, Di Lenarda A, Salcedo EE, Towbin JA, Saffitz JE, Marcus FI, Zareba W, Taylor MR, Mestroni LJournal of the American Heart AssociationArrhythmogenic Phenotype in Dilated Cardiomyopathy: Natural History and Predictors of Life-Threatening Arrhythmias. J Am Heart Assoc. 2015 Oct 16; 4(10):e002149.J Am Heart Assoc2015-10-16T00:00:002015Arrhythmogenic Phenotype in Dilated Cardiomyopathy: Natural History and Predictors of Life-Threatening Arrhythmias.Authorship 4531145Authorship 632935Authorship 708652Authorship 8648411Authorship 86547013Authorship 8663741726850880Asimaki A, Protonotarios A, James CA, Chelko SP, Tichnell C, Murray B, Tsatsopoulou A, Anastasakis A, te Riele A, Kléber AG, Judge DP, Calkins H, Saffitz JECirculation. Arrhythmia and electrophysiologyCharacterizing the Molecular Pathology of Arrhythmogenic Cardiomyopathy in Patient Buccal Mucosa Cells. Circ Arrhythm Electrophysiol. 2016 Feb; 9(2):e003688.Circ Arrhythm Electrophysiol2016-02-01T00:00:002016Characterizing the Molecular Pathology of Arrhythmogenic Cardiomyopathy in Patient Buccal Mucosa Cells.26846950Almomani R, Verhagen JM, Herkert JC, Brosens E, van Spaendonck-Zwarts KY, Asimaki A, van der Zwaag PA, Frohn-Mulder IM, Bertoli-Avella AM, Boven LG, van Slegtenhorst MA, van der Smagt JJ, van IJcken WF, Timmer B, van Stuijvenberg M, Verdijk RM, Saffitz JE, du Plessis FA, Michels M, Hofstra RM, Sinke RJ, van Tintelen JP, Wessels MW, Jongbloed JD, van de Laar IMJournal of the American College of CardiologyBiallelic Truncating Mutations in ALPK3 Cause Severe Pediatric Cardiomyopathy. J Am Coll Cardiol. 2016 Feb 09; 67(5):515-25.J Am Coll Cardiol2016-02-09T00:00:002016Biallelic Truncating Mutations in ALPK3 Cause Severe Pediatric Cardiomyopathy.26764149Saffitz JE, Corradi DCardiovascular pathology : the official journal of the Society for Cardiovascular PathologyThe electrical heart: 25 years of discovery in cardiac electrophysiology, arrhythmias and sudden death. Cardiovasc Pathol. 2016 Mar-Apr; 25(2):149-57.Cardiovasc Pathol2015-12-02T00:00:002015The electrical heart: 25 years of discovery in cardiac electrophysiology, arrhythmias and sudden death.Authorship 2954023Authorship 2960281Authorship 37769119Authorship 876300426894046Siqueira WC, da Cruz SG, Asimaki A, Saffitz JE, Moreira Mda C, Brasileiro G, Rocha LOAutopsy & case reportsCardiac sarcoidosis with severe involvement of the right ventricle: a case report. Autops Case Rep. 2015 Oct-Dec; 5(4):53-63.Autops Case Rep2015-12-30T00:00:002015Cardiac sarcoidosis with severe involvement of the right ventricle: a case report.Authorship 418794Authorship 56170662Assistant Professor6Fellow or Post Doc0Full Professor5Other FacultyAuthorship 618623Authorship 801133Authorship 910924Authorship 573816Authorship 51644312Authorship 5175092Authorship 5666443Authorship 4798185Authorship 5004179Authorship 51431542019-06-30TOWBIN, JEFFREY ALLEN2013-08-23Genetics, Mechanisms and Clinical Phenotypes of Arrhythmogenic CardiomyopathyR01HL1169062014-09-30SAFFITZ, JEFFREY E2010-04-01Disease Mechanisms in ARVCR01HL1023612008-12-31SAFFITZ, JEFFREY E1998-04-01Cx43 in a Genetic Model of Altered Myocardial ConductionR01HL0585072009-06-30SAFFITZ, JEFFREY E1994-12-29Regulation of Myocardial Gap JunctionsR01HL0505982014-05-31GROSS, RICHARD W1996-09-30Membrane-Mediated Alterations in DiabetesP01HL0572781990-06-30SAFFITZ, JEFFREY E1988-01-11ELECTRON MICROSCOPES10RR0039892012-08-31SAFFITZ, JEFFREY E2009-09-30Determinants of Disease Expression in Arrhythmogenic CardiomyopathyRC1HL1001102001-03-31SAFFITZ, JEFFREY E1998-04-01MULTISITE OPTICAL MAPPING SYSTEMS10RR0129111989-12-31SOBEL, BURTON E1984-09-30SPECIALIZED CENTER OF RESEARCH, ISCHEMIC HEART DISEASEP60HL017646Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorCo-Principal InvestigatorAuthorship 612832Co-Principal InvestigatorPrincipal InvestigatorCo-Principal InvestigatorPrincipal InvestigatorAuthorship 790962Authorship 928371Authorship 932036Authorship 973102Authorship 3927354Authorship 39879313Authorship 4066281Authorship 926588425506190Asimaki A, Kléber AG, MacRae CA, Saffitz JEProgress in pediatric cardiologyArrhythmogenic Cardiomyopathy - New Insights into Disease Mechanisms and Drug Discovery. Prog Pediatr Cardiol. 2014 Dec 01; 37(1-2):3-7.Prog Pediatr Cardiol2014-12-01T00:00:002014Arrhythmogenic Cardiomyopathy - New Insights into Disease Mechanisms and Drug Discovery.Authorship 4247184Authorship 4346162Authorship 4690663Authorship 5498674Authorship 2706692Authorship 288877Authorship 3055605Authorship 3504533Authorship 3943514Authorship 4394361Authorship 5229244Authorship 952057728130335Rowe GC, Asimaki A, Graham EL, Martin KD, Margulies KB, Das S, Saffitz J, Arany ZAmerican journal of physiology. Heart and circulatory physiologyDevelopment of dilated cardiomyopathy and impaired calcium homeostasis with cardiac-specific deletion of ESRRß. Am J Physiol Heart Circ Physiol. 2017 Apr 01; 312(4):H662-H671.Am J Physiol Heart Circ Physiol2017-01-27T00:00:002017Development of dilated cardiomyopathy and impaired calcium homeostasis with cardiac-specific deletion of ESRRß.8755993Darrow BJ, Fast VG, Kléber AG, Beyer EC, Saffitz JECirculation researchFunctional and structural assessment of intercellular communication. Increased conduction velocity and enhanced connexin expression in dibutyryl cAMP-treated cultured cardiac myocytes. Circ Res. 1996 Aug; 79(2):174-83.Circ Res1996-08-01T00:00:001996Functional and structural assessment of intercellular communication. Increased conduction velocity and enhanced connexin expression in dibutyryl cAMP-treated cultured cardiac myocytes.1314497Martin WH, Korte E, Tolley TK, Saffitz JEThe American journal of physiologySkeletal muscle beta-adrenoceptor distribution and responses to isoproterenol in hyperthyroidism. Am J Physiol. 1992 Apr; 262(4 Pt 1):E504-10.Am J Physiol1992-04-01T00:00:001992Skeletal muscle beta-adrenoceptor distribution and responses to isoproterenol in hyperthyroidism.1315641Saffitz JE, Liggett SBCirculation researchSubcellular distribution of beta 2-adrenergic receptors delineated with quantitative ultrastructural autoradiography of radioligand binding sites. Circ Res. 1992 Jun; 70(6):1320-5.Circ Res1992-06-01T00:00:001992Subcellular distribution of beta 2-adrenergic receptors delineated with quantitative ultrastructural autoradiography of radioligand binding sites.8925559Fast VG, Darrow BJ, Saffitz JE, Kléber AGCirculation researchAnisotropic activation spread in heart cell monolayers assessed by high-resolution optical mapping. Role of tissue discontinuities. Circ Res. 1996 Jul; 79(1):115-27.Circ Res1996-07-01T00:00:001996Anisotropic activation spread in heart cell monolayers assessed by high-resolution optical mapping. Role of tissue discontinuities.1310450Kanter HL, Saffitz JE, Beyer ECCirculation researchCardiac myocytes express multiple gap junction proteins. Circ Res. 1992 Feb; 70(2):438-44.Circ Res1992-02-01T00:00:001992Cardiac myocytes express multiple gap junction proteins.10988238Thomas SP, Bircher-Lehmann L, Thomas SA, Zhuang J, Saffitz JE, Kléber AGCirculation researchSynthetic strands of neonatal mouse cardiac myocytes: structural and electrophysiological properties. Circ Res. 2000 Sep 15; 87(6):467-73.Circ Res2000-09-15T00:00:002000Synthetic strands of neonatal mouse cardiac myocytes: structural and electrophysiological properties.11166617Lerner DL, Chapman Q, Green KG, Saffitz JEThe Journal of heart and lung transplantation : the official publication of the International Society for Heart TransplantationReversible down-regulation of connexin43 expression in acute cardiac allograft rejection. J Heart Lung Transplant. 2001 Jan; 20(1):93-7.J Heart Lung Transplant2001-01-01T00:00:002001Reversible down-regulation of connexin43 expression in acute cardiac allograft rejection.15031271Saffitz JE, Kléber AGCirculation researchEffects of mechanical forces and mediators of hypertrophy on remodeling of gap junctions in the heart. Circ Res. 2004 Mar 19; 94(5):585-91.Circ Res2004-03-19T00:00:002004Effects of mechanical forces and mediators of hypertrophy on remodeling of gap junctions in the heart.11593045Liao P, Georgakopoulos D, Kovacs A, Zheng M, Lerner D, Pu H, Saffitz J, Chien K, Xiao RP, Kass DA, Wang YProceedings of the National Academy of Sciences of the United States of AmericaThe in vivo role of p38 MAP kinases in cardiac remodeling and restrictive cardiomyopathy. Proc Natl Acad Sci U S A. 2001 Oct 09; 98(21):12283-8.Proc Natl Acad Sci U S A2001-10-02T00:00:002001The in vivo role of p38 MAP kinases in cardiac remodeling and restrictive cardiomyopathy.11922902Johnson CM, Kanter EM, Green KG, Laing JG, Betsuyaku T, Beyer EC, Steinberg TH, Saffitz JE, Yamada KACardiovascular researchRedistribution of connexin45 in gap junctions of connexin43-deficient hearts. Cardiovasc Res. 2002 Mar; 53(4):921-35.Cardiovasc Res2002-03-01T00:00:002002Redistribution of connexin45 in gap junctions of connexin43-deficient hearts.Authorship 9593411127170944Chelko SP, Asimaki A, Andersen P, Bedja D, Amat-Alarcon N, DeMazumder D, Jasti R, MacRae CA, Leber R, Kleber AG, Saffitz JE, Judge DPJCI insightCentral role for GSK3ß in the pathogenesis of arrhythmogenic cardiomyopathy. JCI Insight. 2016 Apr 21; 1(5).JCI Insight2016-04-21T00:00:002016Central role for GSK3ß in the pathogenesis of arrhythmogenic cardiomyopathy.15705967Shanker AJ, Yamada K, Green KG, Yamada KA, Saffitz JECirculation researchMatrix-protein-specific regulation of Cx43 expression in cardiac myocytes subjected to mechanical load. Circ Res. 2005 Mar 18; 96(5):558-66.Circ Res2005-02-10T00:00:002005Matrix-protein-specific regulation of Cx43 expression in cardiac myocytes subjected to mechanical load.8997276Nash JA, Hammond HK, Saffitz JEThe American journal of physiologySubcellular compartmentalization of Gs alpha in cardiac myocytes and its redistribution in heart failure. Am J Physiol. 1996 Dec; 271(6 Pt 2):H2209-17.Am J Physiol1996-12-01T00:00:001996Subcellular compartmentalization of Gs alpha in cardiac myocytes and its redistribution in heart failure.9495305Thomas SA, Schuessler RB, Berul CI, Beardslee MA, Beyer EC, Mendelsohn ME, Saffitz JECirculationDisparate effects of deficient expression of connexin43 on atrial and ventricular conduction: evidence for chamber-specific molecular determinants of conduction. Circulation. 1998 Feb 24; 97(7):686-91.Circulation1998-02-24T00:00:001998Disparate effects of deficient expression of connexin43 on atrial and ventricular conduction: evidence for chamber-specific molecular determinants of conduction.9739042Djouadi F, Weinheimer CJ, Saffitz JE, Pitchford C, Bastin J, Gonzalez FJ, Kelly DPThe Journal of clinical investigationA gender-related defect in lipid metabolism and glucose homeostasis in peroxisome proliferator- activated receptor alpha- deficient mice. J Clin Invest. 1998 Sep 15; 102(6):1083-91.J Clin Invest1998-09-15T00:00:001998A gender-related defect in lipid metabolism and glucose homeostasis in peroxisome proliferator- activated receptor alpha- deficient mice.9742058Beardslee MA, Laing JG, Beyer EC, Saffitz JECirculation researchRapid turnover of connexin43 in the adult rat heart. Circ Res. 1998 Sep 21; 83(6):629-35.Circ Res1998-09-21T00:00:001998Rapid turnover of connexin43 in the adult rat heart.10662753Lerner DL, Yamada KA, Schuessler RB, Saffitz JECirculationAccelerated onset and increased incidence of ventricular arrhythmias induced by ischemia in Cx43-deficient mice. Circulation. 2000 Feb 08; 101(5):547-52.Circulation2000-02-08T00:00:002000Accelerated onset and increased incidence of ventricular arrhythmias induced by ischemia in Cx43-deficient mice.10342013Saffitz JEAdvances in anatomic pathologyToward a clearer understanding of the link between viral infection of the heart and dilated cardiomyopathy. Adv Anat Pathol. 1999 May; 6(3):154-60.Adv Anat Pathol1999-05-01T00:00:001999Toward a clearer understanding of the link between viral infection of the heart and dilated cardiomyopathy.10535711Kavanagh KM, Guerrero PA, Jugdutt BI, Witkowski FX, Saffitz JECanadian journal of physiology and pharmacologyElectrophysiologic properties and ventricular fibrillation in normal and myopathic hearts. Can J Physiol Pharmacol. 1999 Jul; 77(7):510-9.Can J Physiol Pharmacol1999-07-01T00:00:001999Electrophysiologic properties and ventricular fibrillation in normal and myopathic hearts.10775305Saffitz JEBrazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicasRegulation of intercellular coupling in acute and chronic heart disease. Braz J Med Biol Res. 2000 Apr; 33(4):407-13.Braz J Med Biol Res2000-04-01T00:00:002000Regulation of intercellular coupling in acute and chronic heart disease.8820080Santos-Ocampo SD, Sekarski TJ, Saffitz JE, Bridges ND, Huddleston CB, Spray TL, Canter CEThe Journal of heart and lung transplantation : the official publication of the International Society for Heart TransplantationEchocardiographic characteristics of biopsy-proven cellular rejection in infant heart transplant recipients. J Heart Lung Transplant. 1996 Jan; 15(1 Pt 1):25-34.J Heart Lung Transplant1996-01-01T00:00:001996Echocardiographic characteristics of biopsy-proven cellular rejection in infant heart transplant recipients.11530101Eloff BC, Lerner DL, Yamada KA, Schuessler RB, Saffitz JE, Rosenbaum DSCardiovascular researchHigh resolution optical mapping reveals conduction slowing in connexin43 deficient mice. Cardiovasc Res. 2001 Sep; 51(4):681-90.Cardiovasc Res2001-09-01T00:00:002001High resolution optical mapping reveals conduction slowing in connexin43 deficient mice.11934829Laflamme MA, Myerson D, Saffitz JE, Murry CECirculation researchEvidence for cardiomyocyte repopulation by extracardiac progenitors in transplanted human hearts. Circ Res. 2002 Apr 05; 90(6):634-40.Circ Res2002-04-05T00:00:002002Evidence for cardiomyocyte repopulation by extracardiac progenitors in transplanted human hearts.Authorship 972430128319834Saffitz JECardiovascular pathology : the official journal of the Society for Cardiovascular PathologyMolecular mechanisms in the pathogenesis of arrhythmogenic cardiomyopathy. Cardiovasc Pathol. 2017 May - Jun; 28:51-58.Cardiovasc Pathol2017-02-27T00:00:002017Molecular mechanisms in the pathogenesis of arrhythmogenic cardiomyopathy.15175068Yamada KA, Kanter EM, Green KG, Saffitz JEJournal of cardiovascular electrophysiologyTransmural distribution of connexins in rodent hearts. J Cardiovasc Electrophysiol. 2004 Jun; 15(6):710-5.J Cardiovasc Electrophysiol2004-06-01T00:00:002004Transmural distribution of connexins in rodent hearts.9011578Tsai CC, Saffitz JE, Billadello JJThe Journal of clinical investigationExpression of the Gs protein alpha-subunit disrupts the normal program of differentiation in cultured murine myogenic cells. J Clin Invest. 1997 Jan 01; 99(1):67-76.J Clin Invest1997-01-01T00:00:001997Expression of the Gs protein alpha-subunit disrupts the normal program of differentiation in cultured murine myogenic cells.9741530Dodge SM, Beardslee MA, Darrow BJ, Green KG, Beyer EC, Saffitz JEJournal of the American College of CardiologyEffects of angiotensin II on expression of the gap junction channel protein connexin43 in neonatal rat ventricular myocytes. J Am Coll Cardiol. 1998 Sep; 32(3):800-7.J Am Coll Cardiol1998-09-01T00:00:001998Effects of angiotensin II on expression of the gap junction channel protein connexin43 in neonatal rat ventricular myocytes.10330424Chen Z, Saffitz JE, Latour MA, Schonfeld GThe Journal of clinical investigationTruncated apo B-70.5-containing lipoproteins bind to megalin but not the LDL receptor. J Clin Invest. 1999 May 15; 103(10):1419-30.J Clin Invest1999-05-15T00:00:001999Truncated apo B-70.5-containing lipoproteins bind to megalin but not the LDL receptor.1451259Pogwizd SM, Hoyt RH, Saffitz JE, Corr PB, Cox JL, Cain MECirculationReentrant and focal mechanisms underlying ventricular tachycardia in the human heart. Circulation. 1992 Dec; 86(6):1872-87.Circulation1992-12-01T00:00:001992Reentrant and focal mechanisms underlying ventricular tachycardia in the human heart.12598083Kanno S, Kovacs A, Yamada KA, Saffitz JEJournal of the American College of CardiologyConnexin43 as a determinant of myocardial infarct size following coronary occlusion in mice. J Am Coll Cardiol. 2003 Feb 19; 41(4):681-6.J Am Coll Cardiol2003-02-19T00:00:002003Connexin43 as a determinant of myocardial infarct size following coronary occlusion in mice.16093509Saffitz JEAnnals of the New York Academy of SciencesDependence of electrical coupling on mechanical coupling in cardiac myocytes: insights gained from cardiomyopathies caused by defects in cell-cell connections. Ann N Y Acad Sci. 2005 Jun; 1047:336-44.Ann N Y Acad Sci2005-06-01T00:00:002005Dependence of electrical coupling on mechanical coupling in cardiac myocytes: insights gained from cardiomyopathies caused by defects in cell-cell connections.16171766Reynolds DW, Chen PS, Deal BJ, Donahue JK, Ellenbogen KA, Epstein AE, Friedman PA, Hammill SC, Hohnloser SH, Kanter RJ, Lindsay BD, Natale A, Saffitz J, Stevenson WGHeart rhythmHighlights of Heart Rhythm 2005, the Annual Scientific Sessions of the Heart Rhythm Society, May 4-7, 2005, New Orleans, Louisiana. Heart Rhythm. 2005 Sep; 2(9):1025-33.Heart Rhythm2005-09-01T00:00:002005Highlights of Heart Rhythm 2005, the Annual Scientific Sessions of the Heart Rhythm Society, May 4-7, 2005, New Orleans, Louisiana.9330738Saffitz JEAdvances in experimental medicine and biologyGap junctions: functional effects of molecular structure and tissue distribution. Adv Exp Med Biol. 1997; 430:291-301.Adv Exp Med Biol1997-01-01T00:00:001997Gap junctions: functional effects of molecular structure and tissue distribution.10636198Saffitz JEJournal of cardiovascular electrophysiologyElectrophysiologic remodeling: what happens to gap junctions? J Cardiovasc Electrophysiol. 1999 Dec; 10(12):1684-7.J Cardiovasc Electrophysiol1999-12-01T00:00:001999Electrophysiologic remodeling: what happens to gap junctions?1611151Roysam B, Maffitt DR, Miller MI, Saffitz JE, Thomas LJMicroscopy research and techniqueA personal computer based implementation of the maximum-likelihood method of analysis of electron microscope autoradiographs. Microsc Res Tech. 1992 Jan 01; 20(1):73-86.Microsc Res Tech1992-01-01T00:00:001992A personal computer based implementation of the maximum-likelihood method of analysis of electron microscope autoradiographs.1752962Martin WH, Spina RJ, Korte E, Yarasheski KE, Angelopoulos TJ, Nemeth PM, Saffitz JEThe Journal of clinical investigationMechanisms of impaired exercise capacity in short duration experimental hyperthyroidism. J Clin Invest. 1991 Dec; 88(6):2047-53.J Clin Invest1991-12-01T00:00:001991Mechanisms of impaired exercise capacity in short duration experimental hyperthyroidism.14678136Yamada KA, Rogers JG, Sundset R, Steinberg TH, Saffitz JJournal of cardiovascular electrophysiologyUp-regulation of connexin45 in heart failure. J Cardiovasc Electrophysiol. 2003 Nov; 14(11):1205-12.J Cardiovasc Electrophysiol2003-11-01T00:00:002003Up-regulation of connexin45 in heart failure.11600334Kanno S, Saffitz JECardiovascular pathology : the official journal of the Society for Cardiovascular PathologyThe role of myocardial gap junctions in electrical conduction and arrhythmogenesis. Cardiovasc Pathol. 2001 Jul-Aug; 10(4):169-77.Cardiovasc Pathol2001-07-01T00:00:002001The role of myocardial gap junctions in electrical conduction and arrhythmogenesis.9529165Kwong KF, Schuessler RB, Green KG, Laing JG, Beyer EC, Boineau JP, Saffitz JECirculation researchDifferential expression of gap junction proteins in the canine sinus node. Circ Res. 1998 Mar 23; 82(5):604-12.Circ Res1998-03-23T00:00:001998Differential expression of gap junction proteins in the canine sinus node.17213206Mancuso DJ, Han X, Jenkins CM, Lehman JJ, Sambandam N, Sims HF, Yang J, Yan W, Yang K, Green K, Abendschein DR, Saffitz JE, Gross RWThe Journal of biological chemistryDramatic accumulation of triglycerides and precipitation of cardiac hemodynamic dysfunction during brief caloric restriction in transgenic myocardium expressing human calcium-independent phospholipase A2gamma. J Biol Chem. 2007 Mar 23; 282(12):9216-27.J Biol Chem2007-01-09T00:00:002007Dramatic accumulation of triglycerides and precipitation of cardiac hemodynamic dysfunction during brief caloric restriction in transgenic myocardium expressing human calcium-independent phospholipase A2gamma.17585361Saffitz JE, Hames KY, Kanno SThe Journal of membrane biologyRemodeling of gap junctions in ischemic and nonischemic forms of heart disease. J Membr Biol. 2007 Aug; 218(1-3):65-71.J Membr Biol2007-06-22T00:00:002007Remodeling of gap junctions in ischemic and nonischemic forms of heart disease.9747439Laing JG, Tadros PN, Green K, Saffitz JE, Beyer ECCardiovascular researchProteolysis of connexin43-containing gap junctions in normal and heat-stressed cardiac myocytes. Cardiovasc Res. 1998 Jun; 38(3):711-8.Cardiovasc Res1998-06-01T00:00:001998Proteolysis of connexin43-containing gap junctions in normal and heat-stressed cardiac myocytes.11285300Chiu HC, Kovacs A, Ford DA, Hsu FF, Garcia R, Herrero P, Saffitz JE, Schaffer JEThe Journal of clinical investigationA novel mouse model of lipotoxic cardiomyopathy. J Clin Invest. 2001 Apr; 107(7):813-22.J Clin Invest2001-04-01T00:00:002001A novel mouse model of lipotoxic cardiomyopathy.11942595Saffitz JE, Kaplan SRJournal of cardiovascular electrophysiologyPathologic basis of conduction disturbances: the challenge to move beyond microscopic anatomy. J Cardiovasc Electrophysiol. 2002 Mar; 13(3):265-6.J Cardiovasc Electrophysiol2002-03-01T00:00:002002Pathologic basis of conduction disturbances: the challenge to move beyond microscopic anatomy.330 Brookline AveBeth Israel Deaconess Med CtrFinard 207, Pathology330 Brookline AveBoston02215MA12050601Kanno S, Lerner DL, Schuessler RB, Betsuyaku T, Yamada KA, Saffitz JE, Kovacs AJournal of the American Society of Echocardiography : official publication of the American Society of EchocardiographyEchocardiographic evaluation of ventricular remodeling in a mouse model of myocardial infarction. J Am Soc Echocardiogr. 2002 Jun; 15(6):601-9.J Am Soc Echocardiogr2002-06-01T00:00:002002Echocardiographic evaluation of ventricular remodeling in a mouse model of myocardial infarction.12615667Chen Z, Fitzgerald RL, Saffitz JE, Semenkovich CF, Schonfeld GArteriosclerosis, thrombosis, and vascular biologyAmino terminal 38.9% of apolipoprotein B-100 is sufficient to support cholesterol-rich lipoprotein production and atherosclerosis. Arterioscler Thromb Vasc Biol. 2003 Apr 01; 23(4):668-74.Arterioscler Thromb Vasc Biol2003-02-20T00:00:002003Amino terminal 38.9% of apolipoprotein B-100 is sufficient to support cholesterol-rich lipoprotein production and atherosclerosis.2337178Hoyt RH, Cohen ML, Corr PB, Saffitz JEThe American journal of physiologyAlterations of intercellular junctions induced by hypoxia in canine myocardium. Am J Physiol. 1990 May; 258(5 Pt 2):H1439-48.Am J Physiol1990-05-01T00:00:001990Alterations of intercellular junctions induced by hypoxia in canine myocardium.10466495Antzelevitch C, Shimizu W, Yan GX, Sicouri S, Weissenburger J, Nesterenko VV, Burashnikov A, Di Diego J, Saffitz J, Thomas GPJournal of cardiovascular electrophysiologyThe M cell: its contribution to the ECG and to normal and abnormal electrical function of the heart. J Cardiovasc Electrophysiol. 1999 Aug; 10(8):1124-52.J Cardiovasc Electrophysiol1999-08-01T00:00:001999The M cell: its contribution to the ECG and to normal and abnormal electrical function of the heart.10775147Saffitz JE, Green KG, Kraft WJ, Schechtman KB, Yamada KAAmerican journal of physiology. Heart and circulatory physiologyEffects of diminished expression of connexin43 on gap junction number and size in ventricular myocardium. Am J Physiol Heart Circ Physiol. 2000 May; 278(5):H1662-70.Am J Physiol Heart Circ Physiol2000-05-01T00:00:002000Effects of diminished expression of connexin43 on gap junction number and size in ventricular myocardium.19095137Saffitz JEJournal of the American College of CardiologyExpanding the spectrum of arrhythmogenic cardiomyopathy. J Am Coll Cardiol. 2008 Dec 16; 52(25):2188-9.J Am Coll Cardiol2008-12-16T00:00:002008Expanding the spectrum of arrhythmogenic cardiomyopathy.16265643Zheng J, El Naqa I, Rowold FE, Pilgram TK, Woodard PK, Saffitz JE, Tang DMagnetic resonance in medicineQuantitative assessment of coronary artery plaque vulnerability by high-resolution magnetic resonance imaging and computational biomechanics: a pilot study ex vivo. Magn Reson Med. 2005 Dec; 54(6):1360-8.Magn Reson Med2005-12-01T00:00:002005Quantitative assessment of coronary artery plaque vulnerability by high-resolution magnetic resonance imaging and computational biomechanics: a pilot study ex vivo.1764103Wong EC, Saffitz JE, McDonald JMBiochemical and biophysical research communicationsAssociation of calmodulin with isolated nuclei from rat hepatocytes. Biochem Biophys Res Commun. 1991 Dec 31; 181(3):1548-56.Biochem Biophys Res Commun1991-12-31T00:00:001991Association of calmodulin with isolated nuclei from rat hepatocytes.15913582Gard JJ, Yamada K, Green KG, Eloff BC, Rosenbaum DS, Wang X, Robbins J, Schuessler RB, Yamada KA, Saffitz JECardiovascular researchRemodeling of gap junctions and slow conduction in a mouse model of desmin-related cardiomyopathy. 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N Engl J Med. 2006 Jun 22; 354(25):2712-4.N Engl J Med2006-06-22T00:00:002006Connexins, conduction, and atrial fibrillation.2225408Wareing TH, Saffitz JE, Kouchoukos NTCirculationUse of single internal mammary artery grafts in older patients. Circulation. 1990 Nov; 82(5 Suppl):IV224-8.Circulation1990-11-01T00:00:001990Use of single internal mammary artery grafts in older patients.15192022Beauchamp P, Choby C, Desplantez T, de Peyer K, Green K, Yamada KA, Weingart R, Saffitz JE, Kléber AGCirculation researchElectrical propagation in synthetic ventricular myocyte strands from germline connexin43 knockout mice. Circ Res. 2004 Jul 23; 95(2):170-8.Circ Res2004-06-10T00:00:002004Electrical propagation in synthetic ventricular myocyte strands from germline connexin43 knockout mice.15851108Kaplan SR, Gard JJ, Protonotarios N, Tsatsopoulou A, Spiliopoulou C, Anastasakis A, Squarcioni CP, McKenna WJ, Thiene G, Basso C, Brousse N, Fontaine G, Saffitz JEHeart rhythmRemodeling of myocyte gap junctions in arrhythmogenic right ventricular cardiomyopathy due to a deletion in plakoglobin (Naxos disease). Heart Rhythm. 2004 May; 1(1):3-11.Heart Rhythm2004-05-01T00:00:002004Remodeling of myocyte gap junctions in arrhythmogenic right ventricular cardiomyopathy due to a deletion in plakoglobin (Naxos disease).18163233Sundset R, Ytrehus K, Zhang Y, Saffitz JE, Yamada KACell communication & adhesionRepeated simulated ischemia and protection against gap junctional uncoupling. Cell Commun Adhes. 2007 Sep-Oct; 14(5):239-49.Cell Commun Adhes2007-09-01T00:00:002007Repeated simulated ischemia and protection against gap junctional uncoupling.10533569Saffitz JE, Schuessler RB, Yamada KACardiovascular researchMechanisms of remodeling of gap junction distributions and the development of anatomic substrates of arrhythmias. Cardiovasc Res. 1999 May; 42(2):309-17.Cardiovasc Res1999-05-01T00:00:001999Mechanisms of remodeling of gap junction distributions and the development of anatomic substrates of arrhythmias.22883635Saffitz JE, Kléber AGJournal of the American College of CardiologyGap junctions, slow conduction, and ventricular tachycardia after myocardial infarction. J Am Coll Cardiol. 2012 Sep 18; 60(12):1111-3.J Am Coll Cardiol2012-08-08T00:00:002012Gap junctions, slow conduction, and ventricular tachycardia after myocardial infarction.19541548Saffitz JEHeart rhythmArrhythmogenic cardiomyopathy and abnormalities of cell-to-cell coupling. Heart Rhythm. 2009 Aug; 6(8 Suppl):S62-5.Heart Rhythm2009-03-03T00:00:002009Arrhythmogenic cardiomyopathy and abnormalities of cell-to-cell coupling.3122582Miyazaki Y, Gross RW, Sobel BE, Saffitz JEThe American journal of physiologyBiochemical and subcellular distribution of arachidonic acid in rat myocardium. Am J Physiol. 1987 Dec; 253(6 Pt 1):C846-53.Am J Physiol1987-12-01T00:00:001987Biochemical and subcellular distribution of arachidonic acid in rat myocardium.21502420Tonellato PJ, Crawford JM, Boguski MS, Saffitz JEAmerican journal of clinical pathologyA national agenda for the future of pathology in personalized medicine: report of the proceedings of a meeting at the Banbury Conference Center on genome-era pathology, precision diagnostics, and preemptive care: a stakeholder summit. 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