Lois Elaine Hodgson Smith, M.D., Ph.D.
Title Professor of Ophthalmology Institution Boston Children's Hospital Address Childrens Hospital
Ophthalmology
300 Longwood Ave
Boston MA 02115
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Overview
Lois Smith MD, PhD, has been Professor of Ophthalmology since 2007. Dr. Smith's research accomplishments include the development and standardization of the mouse model of oxygen-induced retinopathy; basic mechanisms of vascular growth and translation to the clinic via VEGF; growth hormone and insulin-like growth factor in retinopathy; the role of omega-3 and omega-6 polyunsaturated fatty acids and other lipids in photoreceptor metabolism driving angiogenesis; and photoreceptor energy deficiency as cause of neovascular AMD. Dr. Smith's notable recent accomplishments include development of mitochondrial functional mapping of the retina and optic nerve; development of FGF21 as a treatment for diseases with depressed mitochondrial function, including retinal degenerations (retinitis pigmentosa), AMD, diabetic retinopathy, and ROP; the development of GPR40 and GPR120 as targets for improving mitochondrial function in disease; and SOCS3 as a modulator of inflammation in photoreceptor signaling.
Research
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R01EY030904
(SMITH, LOIS)
Jan 1, 2020 - Dec 31, 2023
Glucose/lipid metabolism and vessel development in phase I ROP
Role: Principal Investigator
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5R24EY024868-04
(SMITH, LOIS)
Apr 1, 2015 - Mar 31, 2019
Novel therapies to inhibit diabetic retinopathy
Role Description: This award will fund studies that will coordinate bench research with clinical trials of LCPUFA and cyclooxygenase inhibition in retinopathy
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R01EY022275
(SMITH, LOIS)
May 1, 2012 - Apr 30, 2016
Neuronal guidance molecules control revascularization in retinopathy
Role: Principal Investigator
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(SMITH, LOIS)
Apr 1, 2007 - Mar 31, 2019
Alcon Research Institute Award
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R01EY017017
(FU, ZHONGJIE ;SMITH, LOIS)
Jul 1, 2006 - Jun 30, 2027
Dietary control of angiogenesis in retinopathy models
Role: Principal Investigator
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R21EY014811
(SMITH, LOIS)
Sep 30, 2002 - Aug 31, 2005
Surrogate Markers for Early Stage Diabetic Retinopathy
Role: Principal Investigator
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CK# 203352
(SMITH, LOIS)
Jul 1, 1999 - Jul 31, 2022
V Kann Rasmussen Foundation
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R01EY008670
(SMITH, LOIS)
Sep 30, 1992 - Nov 30, 2008
Developmental Retinal Neovascularization
Role: Principal Investigator
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M01RR002172
(MANDELL, JAMES WILLIAM)
Jan 1, 1983 - Mar 31, 2009
General Clinical Research Center
Role: Co-Principal Investigator
Bibliographic
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