BS100BethStevensBeth Stevens, Ph.D.42.33743600000000-71.1054470000000071783Stevens, Beth617/919-2979Associate Professor of Neurologycatalyst:eCommonsLogineCommons Loginprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:address2address line 2vivo:address3address line 3vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:personInPositionpositionsvivo:phoneNumberphonePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofvivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonAuthorship 1061476129704318Stevens B, Schafer DPDevelopmental neurobiologyRoles of microglia in nervous system development, plasticity, and disease. Dev Neurobiol. 2018 Jun; 78(6):559-560.Dev Neurobiol2018-04-27T00:00:002018Roles of microglia in nervous system development, plasticity, and disease.Authorship 10701321029809138Giera S, Luo R, Ying Y, Ackerman SD, Jeong SJ, Stoveken HM, Folts CJ, Welsh CA, Tall GG, Stevens B, Monk KR, Piao XeLifeMicroglial transglutaminase-2 drives myelination and myelin repair via GPR56/ADGRG1 in oligodendrocyte precursor cells. Elife. 2018 05 29; 7.Elife2018-05-29T00:00:002018Microglial transglutaminase-2 drives myelination and myelin repair via GPR56/ADGRG1 in oligodendrocyte precursor cells.22715882Stephan AH, Barres BA, Stevens BAnnual review of neuroscienceThe complement system: an unexpected role in synaptic pruning during development and disease. Annu Rev Neurosci. 2012; 35:369-89.Annu Rev Neurosci2012-01-01T00:00:002012The complement system: an unexpected role in synaptic pruning during development and disease.18083105Stevens B, Allen NJ, Vazquez LE, Howell GR, Christopherson KS, Nouri N, Micheva KD, Mehalow AK, Huberman AD, Stafford B, Sher A, Litke AM, Lambris JD, Smith SJ, John SW, Barres BACellThe classical complement cascade mediates CNS synapse elimination. Cell. 2007 Dec 14; 131(6):1164-78.Cell2007-12-14T00:00:002007The classical complement cascade mediates CNS synapse elimination.Authorship 10722881229909984Qin Y, Garrison BS, Ma W, Wang R, Jiang A, Li J, Mistry M, Bronson RT, Santoro D, Franco C, Robinton DA, Stevens B, Rossi DJ, Lu C, Springer TACellA Milieu Molecule for TGF-ß Required for Microglia Function in the Nervous System. Cell. 2018 06 28; 174(1):156-171.e16.Cell2018-06-14T00:00:002018A Milieu Molecule for TGF-ß Required for Microglia Function in the Nervous System.22632727Schafer DP, Lehrman EK, Kautzman AG, Koyama R, Mardinly AR, Yamasaki R, Ransohoff RM, Greenberg ME, Barres BA, Stevens BNeuronMicroglia sculpt postnatal neural circuits in an activity and complement-dependent manner. Neuron. 2012 May 24; 74(4):691-705.Neuron2012-05-24T00:00:002012Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner.Authorship 1079522229469125Johnson MB, Stevens BNaturePruning hypothesis comes of age. Nature. 2018 02 22; 554(7693):438-439.Nature2018-02-22T00:00:002018Pruning hypothesis comes of age.Authorship 1086797330089221Hammond TR, Robinton D, Stevens BAnnual review of cell and developmental biologyMicroglia and the Brain: Complementary Partners in Development and Disease. Annu Rev Cell Dev Biol. 2018 10 06; 34:523-544.Annu Rev Cell Dev Biol2018-08-08T00:00:002018Microglia and the Brain: Complementary Partners in Development and Disease.Authorship 10913511130185634Nestor J, Arinuma Y, Huerta TS, Kowal C, Nasiri E, Kello N, Fujieda Y, Bialas A, Hammond T, Sriram U, Stevens B, Huerta PT, Volpe BT, Diamond BThe Journal of experimental medicineLupus antibodies induce behavioral changes mediated by microglia and blocked by ACE inhibitors. J Exp Med. 2018 10 01; 215(10):2554-2566.J Exp Med2018-09-05T00:00:002018Lupus antibodies induce behavioral changes mediated by microglia and blocked by ACE inhibitors.Authorship 10983301130308165Lehrman EK, Wilton DK, Litvina EY, Welsh CA, Chang ST, Frouin A, Walker AJ, Heller MD, Umemori H, Chen C, Stevens BNeuronCD47 Protects Synapses from Excess Microglia-Mediated Pruning during Development. Neuron. 2018 10 10; 100(1):120-134.e6.Neuron2018-10-10T00:00:002018CD47 Protects Synapses from Excess Microglia-Mediated Pruning during Development.Authorship 11159111930471926Hammond TR, Dufort C, Dissing-Olesen L, Giera S, Young A, Wysoker A, Walker AJ, Gergits F, Segel M, Nemesh J, Marsh SE, Saunders A, Macosko E, Ginhoux F, Chen J, Franklin RJM, Piao X, McCarroll SA, Stevens BImmunitySingle-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes. Immunity. 2019 01 15; 50(1):253-271.e6.Immunity2018-11-21T00:00:002018Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes.20375278Chu Y, Jin X, Parada I, Pesic A, Stevens B, Barres B, Prince DAProceedings of the National Academy of Sciences of the United States of AmericaEnhanced synaptic connectivity and epilepsy in C1q knockout mice. Proc Natl Acad Sci U S A. 2010 Apr 27; 107(17):7975-80.Proc Natl Acad Sci U S A2010-04-07T00:00:002010Enhanced synaptic connectivity and epilepsy in C1q knockout mice.2020-06-30YANG, XIANGDONG WILLIAM2014-07-01Complement-Microglia Interaction in Synaptic Loss and Neurodegeneration in HDR01NS0842982018-02-28STEVENS, BETH ANN2017-03-012017 Glial Biology Gordon Research Conference & Gordon Research SeminarR13NS1019052006-12-31STEVENS, BETH ANN2004-01-01How is the Blood-Brain Barrier Formed?F32NS0469222018-07-31STEVENS, BETH ANN2011-09-01Investigating the Role of Glia in Activity-Dependent Synapse EliminationR01NS0710082020-08-31HOWELL, GARETH R2015-09-30Investigating the Role of Complement-expressing Myeloid Cells in Synapse Loss and Vascular Compromise in Alzheimers DiseaseRF1AG051496Co-Principal InvestigatorPrincipal InvestigatorCo-Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal Investigator18471889Chen Y, Stevens B, Chang J, Milbrandt J, Barres BA, Hell JWJournal of neuroscience methodsNS21: re-defined and modified supplement B27 for neuronal cultures. J Neurosci Methods. 2008 Jun 30; 171(2):239-47.J Neurosci Methods2008-04-01T00:00:002008NS21: re-defined and modified supplement B27 for neuronal cultures.D009457Anatomy4829290.648553NeurogliaD017628Anatomy54712500.535055MicrogliaD013569Anatomy58417190.494405SynapsesD002490Anatomy78713640.563617Central Nervous SystemAuthorship 1146049330995509Hammond TR, Marsh SE, Stevens BImmunityImmune Signaling in Neurodegeneration. Immunity. 2019 04 16; 50(4):955-974.Immunity2019-04-16T00:00:002019Immune Signaling in Neurodegeneration.D009473Physiology57014170.523753Neuronal PlasticityEpidemiologyNeurobiologyNeurologyPsychiatryBrigham and Women's HospitalBoston Children's HospitalHarvard Medical SchoolHarvard T.H. Chan School of Public HealthMassachusetts General HospitalPCR1PeterRaffalliPeter C. Raffalli, M.D.42.33743600000000-71.1054470000000035587Raffalli, PeterAssistant Professor of NeurologyKP59KiranMaskiKiran Prasad Maski, M.D.42.33743600000000-71.1054470000000064551Maski, KiranAssociate Professor of Neurology1197selected publications9.87460.0047681382research areas4.035890.032927352coauthor of111.64120.356260similar toNTM2NicoleBaumerNicole Tara Baumer, M.D.42.33743600000000-71.1054470000000074584Baumer, NicoleAssistant Professor of NeurologyAMW6AlecWalkerAlec Walker, D.P.H., M.D.42.33517680000000-71.1024021000000072216Walker, AlecAdjunct Professor of EpidemiologyOB17OlegButovskyOleg Butovsky, Ph.D.42.33837200000000-71.1032690000000017272Butovsky, OlegAssociate Professor of NeurologyAuthorship 1159116931167136Bernier LP, Bohlen CJ, York EM, Choi HB, Kamyabi A, Dissing-Olesen L, Hefendehl JK, Collins HY, Stevens B, Barres BA, MacVicar BACell reportsNanoscale Surveillance of the Brain by Microglia via cAMP-Regulated Filopodia. Cell Rep. 2019 06 04; 27(10):2895-2908.e4.Cell Rep2019-06-04T00:00:002019Nanoscale Surveillance of the Brain by Microglia via cAMP-Regulated Filopodia.WGR1WadeRegehrWade G. Regehr, Ph.D.42.33602040000000-71.1034325000000061089Regehr, WadeBullard Professor of NeurobiologyBTH2BradleyHymanBradley Theodore Hyman, M.D., Ph.D.42.37904200000000-71.051481000000004393Hyman, BradleyJohn B. Penney, Jr. Professor of NeurologyMEG4MichaelGreenbergMichael Eldon Greenberg, Ph.D.42.33602040000000-71.1034325000000080338Greenberg, MichaelNathan Marsh Pusey Professor of NeurobiologyCC3ChinfeiChenChinfei Chen, M.D., Ph.D.42.33743600000000-71.1054470000000042064Chen, ChinfeiProfessor of NeurologyJL134JonathanLiptonJonathan Lipton, M.D., Ph.D.42.33743600000000-71.1054470000000083893Lipton, JonathanAssistant Professor of NeurologyFJQ1FranciscoQuintanaFrancisco Javier Quintana, Ph.D.42.33837200000000-71.1032690000000082105Quintana, FranciscoProfessor of NeurologyEM125EvanMacoskoEvan Macosko, M.D., Ph.D.42.36220530000000-71.0672584000000088984Macosko, EvanAssociate Professor of PsychiatryDW110DanielWiltonDaniel Wilton, Ph.D.115023Wilton, DanielResearch Fellow in NeurologyAuthorship 1170075331283900Wilton DK, Dissing-Olesen L, Stevens BAnnual review of neuroscienceNeuron-Glia Signaling in Synapse Elimination. Annu Rev Neurosci. 2019 07 08; 42:107-127.Annu Rev Neurosci2019-07-08T00:00:002019Neuron-Glia Signaling in Synapse Elimination.Authorship 1190927418786171Alexander JJ, Anderson AJ, Barnum SR, Stevens B, Tenner AJJournal of neurochemistryThe complement cascade: Yin-Yang in neuroinflammation--neuro-protection and -degeneration. J Neurochem. 2008 Dec; 107(5):1169-87.J Neurochem2008-10-24T00:00:002008The complement cascade: Yin-Yang in neuroinflammation--neuro-protection and -degeneration.true1Associate Professor of NeurologyAssociate Professor of Neurologytrue1Professor of NeurologyProfessor of Neurologytrue1John B. Penney, Jr. Professor of NeurologyJohn B. Penney, Jr. Professor of NeurologyAuthorship 1209609431801811Welsh CA, Stephany CÉ, Sapp RW, Stevens BThe Journal of neuroscience : the official journal of the Society for NeuroscienceOcular Dominance Plasticity in Binocular Primary Visual Cortex Does Not Require C1q. J Neurosci. 2020 01 22; 40(4):769-783.J Neurosci2019-12-04T00:00:002019Ocular Dominance Plasticity in Binocular Primary Visual Cortex Does Not Require C1q.2024-11-30HOOKER, JACOB M. ;STEVENS, BETH ANN2019-12-01COX-2-selective PET imaging as an onset marker of Huntington's diseaseR01NS111168Co-Principal InvestigatorAuthorship 1231095432150529Wallace J, Lord J, Dissing-Olesen L, Stevens B, Murthy VNeLifeMicroglial depletion disrupts normal functional development of adult-born neurons in the olfactory bulb. Elife. 2020 03 09; 9.Elife2020-03-09T00:00:002020Microglial depletion disrupts normal functional development of adult-born neurons in the olfactory bulb.Authorship 12504321132452062Li T, Chiou B, Gilman CK, Luo R, Koshi T, Yu D, Oak HC, Giera S, Johnson-Venkatesh E, Muthukumar AK, Stevens B, Umemori H, Piao XThe EMBO journalA splicing isoform of GPR56 mediates microglial synaptic refinement via phosphatidylserine binding. EMBO J. 2020 08 17; 39(16):e104136.EMBO J2020-05-25T00:00:002020A splicing isoform of GPR56 mediates microglial synaptic refinement via phosphatidylserine binding.Authorship 1261169232593752Wilton DK, Stevens BNeurobiology of diseaseThe contribution of glial cells to Huntington's disease pathogenesis. Neurobiol Dis. 2020 09; 143:104963.Neurobiol Dis2020-06-25T00:00:002020The contribution of glial cells to Huntington's disease pathogenesis.Authorship 12693151632657463Scott-Hewitt N, Perrucci F, Morini R, Erreni M, Mahoney M, Witkowska A, Carey A, Faggiani E, Schuetz LT, Mason S, Tamborini M, Bizzotto M, Passoni L, Filipello F, Jahn R, Stevens B, Matteoli MThe EMBO journalLocal externalization of phosphatidylserine mediates developmental synaptic pruning by microglia. EMBO J. 2020 08 17; 39(16):e105380.EMBO J2020-07-13T00:00:002020Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia.Authorship 12774203Authorship 12790331032819809Liddelow SA, Marsh SE, Stevens BTrends in immunologyMicroglia and Astrocytes in Disease: Dynamic Duo or Partners in Crime? Trends Immunol. 2020 09; 41(9):820-835.Trends Immunol2020-08-17T00:00:002020Microglia and Astrocytes in Disease: Dynamic Duo or Partners in Crime?32769120Zarantonello A, Presumey J, Simoni L, Yalcin E, Fox R, Hansen A, Olesen HG, Thiel S, Johnson MB, Stevens B, Laursen NS, Carroll MC, Andersen GRJournal of immunology (Baltimore, Md. : 1950)An Ultrahigh-Affinity Complement C4b-Specific Nanobody Inhibits In Vivo Assembly of the Classical Pathway Proconvertase. J Immunol. 2020 09 15; 205(6):1678-1694.J Immunol2020-08-07T00:00:002020An Ultrahigh-Affinity Complement C4b-Specific Nanobody Inhibits In Vivo Assembly of the Classical Pathway Proconvertase.Authorship 1287924532931754Cheadle L, Rivera SA, Phelps JS, Ennis KA, Stevens B, Burkly LC, Lee WA, Greenberg MENeuronSensory Experience Engages Microglia to Shape Neural Connectivity through a Non-Phagocytic Mechanism. Neuron. 2020 11 11; 108(3):451-468.e9.Neuron2020-09-14T00:00:002020Sensory Experience Engages Microglia to Shape Neural Connectivity through a Non-Phagocytic Mechanism.Authorship 1314983733353966Yilmaz M, Yalcin E, Presumey J, Aw E, Ma M, Whelan CW, Stevens B, McCarroll SA, Carroll MCNature neuroscienceOverexpression of schizophrenia susceptibility factor human complement C4A promotes excessive synaptic loss and behavioral changes in mice. Nat Neurosci. 2021 02; 24(2):214-224.Nat Neurosci2020-12-22T00:00:002020Overexpression of schizophrenia susceptibility factor human complement C4A promotes excessive synaptic loss and behavioral changes in mice.Authorship 13426021133766915Mifflin L, Hu Z, Dufort C, Hession CC, Walker AJ, Niu K, Zhu H, Liu N, Liu JS, Levin JZ, Stevens B, Yuan J, Zou CProceedings of the National Academy of Sciences of the United States of AmericaA RIPK1-regulated inflammatory microglial state in amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A. 2021 03 30; 118(13).Proc Natl Acad Sci U S A2021-03-30T00:00:002021A RIPK1-regulated inflammatory microglial state in amyotrophic lateral sclerosis.Authorship 13608233634083789Young AMH, Kumasaka N, Calvert F, Hammond TR, Knights A, Panousis N, Park JS, Schwartzentruber J, Liu J, Kundu K, Segel M, Murphy NA, McMurran CE, Bulstrode H, Correia J, Budohoski KP, Joannides A, Guilfoyle MR, Trivedi R, Kirollos R, Morris R, Garnett MR, Timofeev I, Jalloh I, Holland K, Mannion R, Mair R, Watts C, Price SJ, Kirkpatrick PJ, Santarius T, Mountjoy E, Ghoussaini M, Soranzo N, Bayraktar OA, Stevens B, Hutchinson PJ, Franklin RJM, Gaffney DJNature geneticsA map of transcriptional heterogeneity and regulatory variation in human microglia. Nat Genet. 2021 06; 53(6):861-868.Nat Genet2021-06-03T00:00:002021A map of transcriptional heterogeneity and regulatory variation in human microglia.Authorship 16041210Authorship 13734801634233165Favuzzi E, Huang S, Saldi GA, Binan L, Ibrahim LA, Fernández-Otero M, Cao Y, Zeine A, Sefah A, Zheng K, Xu Q, Khlestova E, Farhi SL, Bonneau R, Datta SR, Stevens B, Fishell GCellGABA-receptive microglia selectively sculpt developing inhibitory circuits. Cell. 2021 07 22; 184(15):4048-4063.e32.Cell2021-07-06T00:00:002021GABA-receptive microglia selectively sculpt developing inhibitory circuits.Authorship 1386118934417332Peterson SL, Li Y, Sun CJ, Wong KA, Leung KS, de Lima S, Hanovice NJ, Yuki K, Stevens B, Benowitz LIThe Journal of neuroscience : the official journal of the Society for NeuroscienceRetinal Ganglion Cell Axon Regeneration Requires Complement and Myeloid Cell Activity within the Optic Nerve. J Neurosci. 2021 10 13; 41(41):8508-8531.J Neurosci2021-08-20T00:00:002021Retinal Ganglion Cell Axon Regeneration Requires Complement and Myeloid Cell Activity within the Optic Nerve.2023-08-31STEVENS, BETH ANN2015-03-15Mechanisms of activity-dependent microglia-neuron interactions in development and diseaseRF1NS092578Principal InvestigatorAuthorship 139836317Authorship 13987621Authorship 1401021232094942Johnson MB, Stevens BNaturePruning hypothesis comes of age. Nature. 2018 Feb; 554(7693):438-439.Nature2018-02-01T00:00:002018Pruning hypothesis comes of age.34580464Stevens B, Johnson MBNature reviews. ImmunologyThe complement cascade repurposed in the brain. Nat Rev Immunol. 2021 10; 21(10):624-625.Nat Rev Immunol2021-10-01T00:00:002021The complement cascade repurposed in the brain.32938727Pedersen H, Jensen RK, Jensen JMB, Fox R, Pedersen DV, Olesen HG, Hansen AG, Christiansen D, Mazarakis SMM, Lojek N, Hansen P, Gadeberg TAF, Zarantonello A, Laursen NS, Mollnes TE, Johnson MB, Stevens B, Thiel S, Andersen GRJournal of immunology (Baltimore, Md. : 1950)A Complement C3-Specific Nanobody for Modulation of the Alternative Cascade Identifies the C-Terminal Domain of C3b as Functional in C5 Convertase Activity. J Immunol. 2020 10 15; 205(8):2287-2300.J Immunol2020-09-16T00:00:002020A Complement C3-Specific Nanobody for Modulation of the Alternative Cascade Identifies the C-Terminal Domain of C3b as Functional in C5 Convertase Activity.Authorship 14065251634715023Favuzzi E, Huang S, Saldi GA, Binan L, Ibrahim LA, Fernández-Otero M, Cao Y, Zeine A, Sefah A, Zheng K, Xu Q, Khlestova E, Farhi SL, Bonneau R, Datta SR, Stevens B, Fishell GCellGABA-receptive microglia selectively sculpt developing inhibitory circuits. Cell. 2021 Oct 28; 184(22):5686.Cell2021-10-28T00:00:002021GABA-receptive microglia selectively sculpt developing inhibitory circuits.Authorship 14196701734912127Sekar A, Bialas AR, de Rivera H, Davis A, Hammond TR, Kamitaki N, Tooley K, Presumey J, Baum M, Van Doren V, Genovese G, Rose SA, Handsaker RE, Daly MJ, Carroll MC, Stevens B, McCarroll SANatureAuthor Correction: Schizophrenia risk from complex variation of complement component 4. Nature. 2022 Jan; 601(7892):E4-E5.Nature2022-01-01T00:00:002022Author Correction: Schizophrenia risk from complex variation of complement component 4.35045281Qureshi YH, Berman DE, Marsh SE, Klein RL, Patel VM, Simoes S, Kannan S, Petsko GA, Stevens B, Small SACell reportsThe neuronal retromer can regulate both neuronal and microglial phenotypes of Alzheimer's disease. Cell Rep. 2022 01 18; 38(3):110262.Cell Rep2022-01-18T00:00:002022The neuronal retromer can regulate both neuronal and microglial phenotypes of Alzheimer's disease.35027764Bialas AR, Stevens BNature neuroscienceRetraction Note: TGF-ß signaling regulates neuronal C1q expression and developmental synaptic refinement. Nat Neurosci. 2022 Feb; 25(2):265.Nat Neurosci2022-02-01T00:00:002022Retraction Note: TGF-ß signaling regulates neuronal C1q expression and developmental synaptic refinement.Authorship 14246752Authorship 14270609Authorship 14404722335260865Marsh SE, Walker AJ, Kamath T, Dissing-Olesen L, Hammond TR, de Soysa TY, Young AMH, Murphy S, Abdulraouf A, Nadaf N, Dufort C, Walker AC, Lucca LE, Kozareva V, Vanderburg C, Hong S, Bulstrode H, Hutchinson PJ, Gaffney DJ, Hafler DA, Franklin RJM, Macosko EZ, Stevens BNature neuroscienceDissection of artifactual and confounding glial signatures by single-cell sequencing of mouse and human brain. Nat Neurosci. 2022 03; 25(3):306-316.Nat Neurosci2022-03-08T00:00:002022Dissection of artifactual and confounding glial signatures by single-cell sequencing of mouse and human brain.Authorship 2972822Authorship 14844284Authorship 1502810336327895Paolicelli RC, Sierra A, Stevens B, Tremblay ME, Aguzzi A, Ajami B, Amit I, Audinat E, Bechmann I, Bennett M, Bennett F, Bessis A, Biber K, Bilbo S, Blurton-Jones M, Boddeke E, Brites D, Brône B, Brown GC, Butovsky O, Carson MJ, Castellano B, Colonna M, Cowley SA, Cunningham C, Davalos D, De Jager PL, de Strooper B, Denes A, Eggen BJL, Eyo U, Galea E, Garel S, Ginhoux F, Glass CK, Gokce O, Gomez-Nicola D, González B, Gordon S, Graeber MB, Greenhalgh AD, Gressens P, Greter M, Gutmann DH, Haass C, Heneka MT, Heppner FL, Hong S, Hume DA, Jung S, Kettenmann H, Kipnis J, Koyama R, Lemke G, Lynch M, Majewska A, Malcangio M, Malm T, Mancuso R, Masuda T, Matteoli M, McColl BW, Miron VE, Molofsky AV, Monje M, Mracsko E, Nadjar A, Neher JJ, Neniskyte U, Neumann H, Noda M, Peng B, Peri F, Perry VH, Popovich PG, Pridans C, Priller J, Prinz M, Ragozzino D, Ransohoff RM, Salter MW, Schaefer A, Schafer DP, Schwartz M, Simons M, Smith CJ, Streit WJ, Tay TL, Tsai LH, Verkhratsky A, von Bernhardi R, Wake H, Wittamer V, Wolf SA, Wu LJ, Wyss-Coray TNeuronMicroglia states and nomenclature: A field at its crossroads. Neuron. 2022 11 02; 110(21):3458-3483.Neuron2022-11-02T00:00:002022Microglia states and nomenclature: A field at its crossroads.36155944Yvanka de Soysa T, Therrien M, Walker AC, Stevens BSeminars in immunologyRedefining microglia states: Lessons and limits of human and mouse models to study microglia states in neurodegenerative diseases. Semin Immunol. 2022 Sep 22; 60:101651.Semin Immunol2022-09-22T00:00:002022Redefining microglia states: Lessons and limits of human and mouse models to study microglia states in neurodegenerative diseases.Authorship 15122772036563689Rapino F, Natoli T, Limone F, O'Connor E, Blank J, Tegtmeyer M, Chen W, Norabuena E, Narula J, Hazelbaker D, Angelini G, Barrett L, O'Neil A, Beattie UK, Thanos JM, de Rivera H, Sheridan SD, Perlis RH, McCarroll SA, Stevens B, Subramanian A, Nehme R, Rubin LLStem cell reportsSmall-molecule screen reveals pathways that regulate C4 secretion in stem cell-derived astrocytes. Stem Cell Reports. 2023 01 10; 18(1):237-253.Stem Cell Reports2022-12-22T00:00:002022Small-molecule screen reveals pathways that regulate C4 secretion in stem cell-derived astrocytes.Authorship 152927533Authorship 15282091236865221Wieder N, Fried JC, Kim C, Sidhom EH, Brown MR, Marshall JL, Arevalo C, Dvela-Levitt M, Kost-Alimova M, Sieber J, Gabriel KR, Pacheco J, Clish C, Abbasi HS, Singh S, Rutter J, Therrien M, Yoon H, Lai ZW, Baublis A, Subramanian R, Devkota R, Small J, Sreekanth V, Han M, Lim D, Carpenter AE, Flannick J, Finucane H, Haigis MC, Claussnitzer M, Sheu E, Stevens B, Wagner BK, Choudhary A, Shaw JL, Pablo JL, Greka AbioRxiv : the preprint server for biologyFALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity. bioRxiv. 2023 Feb 20.bioRxiv2023-02-20T00:00:002023FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity.36859544Pinho-Ribeiro FA, Deng L, Neel DV, Erdogan O, Basu H, Yang D, Choi S, Walker AJ, Carneiro-Nascimento S, He K, Wu G, Stevens B, Doran KS, Levy D, Chiu IMNatureBacteria hijack a meningeal neuroimmune axis to facilitate brain invasion. Nature. 2023 03; 615(7952):472-481.Nature2023-03-01T00:00:002023Bacteria hijack a meningeal neuroimmune axis to facilitate brain invasion.37075753Wieder N, Fried JC, Kim C, Sidhom EH, Brown MR, Marshall JL, Arevalo C, Dvela-Levitt M, Kost-Alimova M, Sieber J, Gabriel KR, Pacheco J, Clish C, Abbasi HS, Singh S, Rutter JC, Therrien M, Yoon H, Lai ZW, Baublis A, Subramanian R, Devkota R, Small J, Sreekanth V, Han M, Lim D, Carpenter AE, Flannick J, Finucane H, Haigis MC, Claussnitzer M, Sheu E, Stevens B, Wagner BK, Choudhary A, Shaw JL, Pablo JL, Greka ACell metabolismFALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity. Cell Metab. 2023 05 02; 35(5):887-905.e11.Cell Metab2023-04-18T00:00:002023FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity.Authorship 157104724Authorship 156402333Authorship 157169217Authorship 1568904337272510Scott-Hewitt N, Huang Y, Stevens BAnnals of the New York Academy of SciencesConvergent mechanisms of microglia-mediated synaptic dysfunction contribute to diverse neuropathological conditions. Ann N Y Acad Sci. 2023 07; 1525(1):5-27.Ann N Y Acad Sci2023-06-05T00:00:002023Convergent mechanisms of microglia-mediated synaptic dysfunction contribute to diverse neuropathological conditions.37333365Gazestani V, Kamath T, Nadaf NM, Burris SJ, Rooney B, Junkkari A, Vanderburg C, Rauramaa T, Therrien M, Tegtmeyer M, Herukka SK, Abdulraouf A, Marsh S, Malm T, Hiltunen M, Nehme R, Stevens B, Leinonen V, Macosko EZbioRxiv : the preprint server for biologyEarly Alzheimer's disease pathology in human cortex is associated with a transient phase of distinct cell states. bioRxiv. 2023 Jun 05.bioRxiv2023-06-05T00:00:002023Early Alzheimer's disease pathology in human cortex is associated with a transient phase of distinct cell states.37500887Dolan MJ, Therrien M, Jereb S, Kamath T, Gazestani V, Atkeson T, Marsh SE, Goeva A, Lojek NM, Murphy S, White CM, Joung J, Liu B, Limone F, Eggan K, Hacohen N, Bernstein BE, Glass CK, Leinonen V, Blurton-Jones M, Zhang F, Epstein CB, Macosko EZ, Stevens BNature immunologyExposure of iPSC-derived human microglia to brain substrates enables the generation and manipulation of diverse transcriptional states in vitro. Nat Immunol. 2023 08; 24(8):1382-1390.Nat Immunol2023-07-27T00:00:002023Exposure of iPSC-derived human microglia to brain substrates enables the generation and manipulation of diverse transcriptional states in vitro.Authorship 158633022Authorship 158360810Authorship 15846201537575021Rueda-Carrasco J, Sokolova D, Lee SE, Childs T, Jurcáková N, Crowley G, De Schepper S, Ge JZ, Lachica JI, Toomey CE, Freeman OJ, Hardy J, Barnes SJ, Lashley T, Stevens B, Chang S, Hong SThe EMBO journalMicroglia-synapse engulfment via PtdSer-TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models. EMBO J. 2023 Oct 04; 42(19):e113246.EMBO J2023-08-14T00:00:002023Microglia-synapse engulfment via PtdSer-TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models.37758703Dissing-Olesen L, Walker AJ, Feng Q, Barr HJ, Walker AC, Xie L, Wilton DK, Das I, Benowitz LI, Stevens BNature communicationsFEAST: A flow cytometry-based toolkit for interrogating microglial engulfment of synaptic and myelin proteins. Nat Commun. 2023 09 27; 14(1):6015.Nat Commun2023-09-27T00:00:002023FEAST: A flow cytometry-based toolkit for interrogating microglial engulfment of synaptic and myelin proteins.37774681Gazestani V, Kamath T, Nadaf NM, Dougalis A, Burris SJ, Rooney B, Junkkari A, Vanderburg C, Pelkonen A, Gomez-Budia M, Välimäki NN, Rauramaa T, Therrien M, Koivisto AM, Tegtmeyer M, Herukka SK, Abdulraouf A, Marsh SE, Hiltunen M, Nehme R, Malm T, Stevens B, Leinonen V, Macosko EZCellEarly Alzheimer's disease pathology in human cortex involves transient cell states. Cell. 2023 09 28; 186(20):4438-4453.e23.Cell2023-09-28T00:00:002023Early Alzheimer's disease pathology in human cortex involves transient cell states.Authorship 15968491537814059Wilton DK, Mastro K, Heller MD, Gergits FW, Willing CR, Fahey JB, Frouin A, Daggett A, Gu X, Kim YA, Faull RLM, Jayadev S, Yednock T, Yang XW, Stevens BNature medicineMicroglia and complement mediate early corticostriatal synapse loss and cognitive dysfunction in Huntington's disease. Nat Med. 2023 Nov; 29(11):2866-2884.Nat Med2023-10-09T00:00:002023Microglia and complement mediate early corticostriatal synapse loss and cognitive dysfunction in Huntington's disease.true1Associate Professor of PsychiatryAssociate Professor of Psychiatrytrue1Bullard Professor of NeurobiologyBullard Professor of NeurobiologyAuthorship 15994111537919439Wilton DK, Mastro K, Heller MD, Gergits FW, Willing CR, Fahey JB, Frouin A, Daggett A, Gu X, Kim YA, Faull RLM, Jayadev S, Yednock T, Yang XW, Stevens BNature medicineAuthor Correction: Microglia and complement mediate early corticostriatal synapse loss and cognitive dysfunction in Huntington's disease. Nat Med. 2023 Nov; 29(11):2958.Nat Med2023-11-01T00:00:002023Author Correction: Microglia and complement mediate early corticostriatal synapse loss and cognitive dysfunction in Huntington's disease.true1Research Fellow in NeurologyResearch Fellow in Neurologytrue1Research Fellow in NeurologyResearch Fellow in Neurologytrue1Research Fellow in NeurologyResearch Fellow in Neurologytrue1Assistant Professor of NeurologyAssistant Professor of Neurologytrue1Assistant Professor of NeurologyAssistant Professor of Neurologytrue1Adjunct Professor of EpidemiologyAdjunct Professor of Epidemiologytrue1Professor of NeurologyProfessor of Neurologytrue1Associate Professor of NeurologyAssociate Professor of Neurologytrue1Nathan Marsh Pusey Professor of NeurobiologyNathan Marsh Pusey Professor of Neurobiologytrue1Assistant Professor of NeurologyAssistant Professor of Neurologytrue1Associate Professor of NeurologyAssociate Professor of NeurologyAuthorship 3932982Authorship 692149224157239Schafer DP, Stevens BCurrent opinion in neurobiologyPhagocytic glial cells: sculpting synaptic circuits in the developing nervous system. Curr Opin Neurobiol. 2013 Dec; 23(6):1034-40.Curr Opin Neurobiol2013-10-22T00:00:002013Phagocytic glial cells: sculpting synaptic circuits in the developing nervous system.Authorship 694883224162655Bialas AR, Stevens BNature neuroscienceTGF-ß signaling regulates neuronal C1q expression and developmental synaptic refinement. Nat Neurosci. 2013 Dec; 16(12):1773-82.Nat Neurosci2013-10-27T00:00:002013TGF-ß signaling regulates neuronal C1q expression and developmental synaptic refinement.Authorship 2970043Authorship 2787001Authorship 738359424962472Schafer DP, Lehrman EK, Heller CT, Stevens BJournal of visualized experiments : JoVEAn engulfment assay: a protocol to assess interactions between CNS phagocytes and neurons. J Vis Exp. 2014 Jun 08; (88).J Vis Exp2014-06-08T00:00:002014An engulfment assay: a protocol to assess interactions between CNS phagocytes and neurons.Authorship 3679562Authorship 56742711Authorship 4057043Authorship 4405473Authorship 299412Authorship 3375011Authorship 7931222Authorship 8071322Authorship 8045681225607655Giera S, Deng Y, Luo R, Ackerman SD, Mogha A, Monk KR, Ying Y, Jeong SJ, Makinodan M, Bialas AR, Chang BS, Stevens B, Corfas G, Piao XNature communicationsThe adhesion G protein-coupled receptor GPR56 is a cell-autonomous regulator of oligodendrocyte development. Nat Commun. 2015 Jan 21; 6:6121.Nat Commun2015-01-21T00:00:002015The adhesion G protein-coupled receptor GPR56 is a cell-autonomous regulator of oligodendrocyte development.25957677Lehrman EK, Stevens BCellShedding light on glioma growth. Cell. 2015 May 07; 161(4):704-6.Cell2015-05-07T00:00:002015Shedding light on glioma growth.25902477Schafer DP, Stevens BImmunityBrains, Blood, and Guts: MeCP2 Regulates Microglia, Monocytes, and Peripheral Macrophages. Immunity. 2015 Apr 21; 42(4):600-2.Immunity2015-04-21T00:00:002015Brains, Blood, and Guts: MeCP2 Regulates Microglia, Monocytes, and Peripheral Macrophages.Authorship 811845225463024Bilimoria PM, Stevens BBrain researchMicroglia function during brain development: New insights from animal models. Brain Res. 2015 Aug 18; 1617:7-17.Brain Res2014-11-26T00:00:002014Microglia function during brain development: New insights from animal models.Authorship 83765412Authorship 837088222072657Tremblay MÈ, Stevens B, Sierra A, Wake H, Bessis A, Nimmerjahn AThe Journal of neuroscience : the official journal of the Society for NeuroscienceThe role of microglia in the healthy brain. J Neurosci. 2011 Nov 09; 31(45):16064-9.J Neurosci2011-11-09T00:00:002011The role of microglia in the healthy brain.26400934Shi Q, Colodner KJ, Matousek SB, Merry K, Hong S, Kenison JE, Frost JL, Le KX, Li S, Dodart JC, Caldarone BJ, Stevens B, Lemere CAThe Journal of neuroscience : the official journal of the Society for NeuroscienceComplement C3-Deficient Mice Fail to Display Age-Related Hippocampal Decline. J Neurosci. 2015 Sep 23; 35(38):13029-42.J Neurosci2015-09-23T00:00:002015Complement C3-Deficient Mice Fail to Display Age-Related Hippocampal Decline.Authorship 8388752Authorship 8379953Authorship 8389592Authorship 838825426187728Schafer DP, Stevens BCold Spring Harbor perspectives in biologyMicroglia Function in Central Nervous System Development and Plasticity. Cold Spring Harb Perspect Biol. 2015 Jul 17; 7(10):a020545.Cold Spring Harb Perspect Biol2015-07-17T00:00:002015Microglia Function in Central Nervous System Development and Plasticity.24455310Wu LJ, Stevens B, Duan S, MacVicar BANeural plasticityMicroglia in neuronal circuits. Neural Plast. 2013; 2013:586426.Neural Plast2013-12-22T00:00:002013Microglia in neuronal circuits.26431938Wu Y, Dissing-Olesen L, MacVicar BA, Stevens BTrends in immunologyMicroglia: Dynamic Mediators of Synapse Development and Plasticity. Trends Immunol. 2015 Oct; 36(10):605-613.Trends Immunol2015-10-01T00:00:002015Microglia: Dynamic Mediators of Synapse Development and Plasticity.26425672Dissing-Olesen L, Hong S, Stevens BEBioMedicineNew Brain Lymphatic Vessels Drain Old Concepts. EBioMedicine. 2015 Aug; 2(8):776-7.EBioMedicine2015-08-14T00:00:002015New Brain Lymphatic Vessels Drain Old Concepts.Authorship 845777426505565Chung WS, Welsh CA, Barres BA, Stevens BNature neuroscienceDo glia drive synaptic and cognitive impairment in disease? Nat Neurosci. 2015 Nov; 18(11):1539-1545.Nat Neurosci2015-10-27T00:00:002015Do glia drive synaptic and cognitive impairment in disease?26814963Sekar A, Bialas AR, de Rivera H, Davis A, Hammond TR, Kamitaki N, Tooley K, Presumey J, Baum M, Van Doren V, Genovese G, Rose SA, Handsaker RE, Daly MJ, Carroll MC, Stevens B, McCarroll SANatureSchizophrenia risk from complex variation of complement component 4. Nature. 2016 Feb 11; 530(7589):177-83.Nature2016-01-27T00:00:002016Schizophrenia risk from complex variation of complement component 4.Authorship 8670451Authorship 86611317Authorship 864581326912878Stevens B, Muthukumar AKScience (New York, N.Y.)Cellular neuroscience. Differences among astrocytes. Science. 2016 Feb 19; 351(6275):813.Science2016-02-19T00:00:002016Cellular neuroscience. Differences among astrocytes.26745839Hong S, Dissing-Olesen L, Stevens BCurrent opinion in neurobiologyNew insights on the role of microglia in synaptic pruning in health and disease. Curr Opin Neurobiol. 2016 Feb; 36:128-34.Curr Opin Neurobiol2015-12-30T00:00:002015New insights on the role of microglia in synaptic pruning in health and disease.Authorship 848623Authorship 4186171Authorship 8801071327033548Hong S, Beja-Glasser VF, Nfonoyim BM, Frouin A, Li S, Ramakrishnan S, Merry KM, Shi Q, Rosenthal A, Barres BA, Lemere CA, Selkoe DJ, Stevens BScience (New York, N.Y.)Complement and microglia mediate early synapse loss in Alzheimer mouse models. Science. 2016 May 06; 352(6286):712-716.Science2016-03-31T00:00:002016Complement and microglia mediate early synapse loss in Alzheimer mouse models.Authorship 8885612127337340Vasek MJ, Garber C, Dorsey D, Durrant DM, Bollman B, Soung A, Yu J, Perez-Torres C, Frouin A, Wilton DK, Funk K, DeMasters BK, Jiang X, Bowen JR, Mennerick S, Robinson JK, Garbow JR, Tyler KL, Suthar MS, Schmidt RE, Stevens B, Klein RSNatureA complement-microglial axis drives synapse loss during virus-induced memory impairment. Nature. 2016 06 23; 534(7608):538-43.Nature2016-06-23T00:00:002016A complement-microglial axis drives synapse loss during virus-induced memory impairment.2Assistant Professor1Associate Professor6Fellow or Post Doc0Full ProfessorAuthorship 89453511Authorship 8940372Authorship 894810925517933Risher WC, Patel S, Kim IH, Uezu A, Bhagat S, Wilton DK, Pilaz LJ, Singh Alvarado J, Calhan OY, Silver DL, Stevens B, Calakos N, Soderling SH, Eroglu CeLifeAstrocytes refine cortical connectivity at dendritic spines. Elife. 2014 Dec 17; 3.Elife2014-12-17T00:00:002014Astrocytes refine cortical connectivity at dendritic spines.27459063Hong S, Stevens BDevelopmental cellMicroglia: Phagocytosing to Clear, Sculpt, and Eliminate. Dev Cell. 2016 07 25; 38(2):126-8.Dev Cell2016-07-25T00:00:002016Microglia: Phagocytosing to Clear, Sculpt, and Eliminate.27458802Schafer DP, Heller CT, Gunner G, Heller M, Gordon C, Hammond T, Wolf Y, Jung S, Stevens BeLifeMicroglia contribute to circuit defects in Mecp2 null mice independent of microglia-specific loss of Mecp2 expression. Elife. 2016 07 26; 5.Elife2016-07-26T00:00:002016Microglia contribute to circuit defects in Mecp2 null mice independent of microglia-specific loss of Mecp2 expression.Authorship 701412Authorship 5179305Authorship 9099491027565350Loh KH, Stawski PS, Draycott AS, Udeshi ND, Lehrman EK, Wilton DK, Svinkina T, Deerinck TJ, Ellisman MH, Stevens B, Carr SA, Ting AYCellProteomic Analysis of Unbounded Cellular Compartments: Synaptic Clefts. Cell. 2016 Aug 25; 166(5):1295-1307.e21.Cell2016-08-25T00:00:002016Proteomic Analysis of Unbounded Cellular Compartments: Synaptic Clefts.2021-02-28STEVENS, BETH ANN2015-03-15Investigating CD47-SIRPa as novel protective signals during CNS synaptic pruningR01NS092578Authorship 91222018Authorship 9122531Authorship 911522Authorship 913115116805429Stevens BNovartis Foundation symposiumCross-talk between growth factor and purinergic signalling regulates Schwann cell proliferation. Novartis Found Symp. 2006; 276:162-75; discussion 175-80, 233-7, 275-81.Novartis Found Symp2006-01-01T00:00:002006Cross-talk between growth factor and purinergic signalling regulates Schwann cell proliferation.18635944Stevens BNeuro-SignalsNeuron-astrocyte signaling in the development and plasticity of neural circuits. Neurosignals. 2008; 16(4):278-88.Neurosignals2008-07-18T00:00:002008Neuron-astrocyte signaling in the development and plasticity of neural circuits.26967274CellAll You Need Is Mentorship. Cell. 2016 Mar 10; 164(6):1092-1093.Cell2016-03-10T00:00:002016All You Need Is Mentorship.21439553Håvik B, Le Hellard S, Rietschel M, Lybæk H, Djurovic S, Mattheisen M, Mühleisen TW, Degenhardt F, Priebe L, Maier W, Breuer R, Schulze TG, Agartz I, Melle I, Hansen T, Bramham CR, Nöthen MM, Stevens B, Werge T, Andreassen OA, Cichon S, Steen VMBiological psychiatryThe complement control-related genes CSMD1 and CSMD2 associate to schizophrenia. Biol Psychiatry. 2011 Jul 01; 70(1):35-42.Biol Psychiatry2011-03-24T00:00:002011The complement control-related genes CSMD1 and CSMD2 associate to schizophrenia.Authorship 934876227824814Hammond TR, Stevens BNature medicineIncreasing the neurological-disease toolbox using iPSC-derived microglia. Nat Med. 2016 11 08; 22(11):1206-1207.Nat Med2016-11-08T00:00:002016Increasing the neurological-disease toolbox using iPSC-derived microglia.Authorship 944066327943190Hong S, Wilton DK, Stevens B, Richardson DSMethods in molecular biology (Clifton, N.J.)Structured Illumination Microscopy for the Investigation of Synaptic Structure and Function. Methods Mol Biol. 2017; 1538:155-167.Methods Mol Biol2017-01-01T00:00:002017Structured Illumination Microscopy for the Investigation of Synaptic Structure and Function.NS312NicoleScott-HewittNicole Scott-Hewitt, Ph.D.155556Scott-Hewitt, NicoleResearch Fellow in NeurologyAuthorship 9513072028099414Liddelow SA, Guttenplan KA, Clarke LE, Bennett FC, Bohlen CJ, Schirmer L, Bennett ML, Münch AE, Chung WS, Peterson TC, Wilton DK, Frouin A, Napier BA, Panicker N, Kumar M, Buckwalter MS, Rowitch DH, Dawson VL, Dawson TM, Stevens B, Barres BANatureNeurotoxic reactive astrocytes are induced by activated microglia. Nature. 2017 01 26; 541(7638):481-487.Nature2017-01-18T00:00:002017Neurotoxic reactive astrocytes are induced by activated microglia.Authorship 984721728566429Shi Q, Chowdhury S, Ma R, Le KX, Hong S, Caldarone BJ, Stevens B, Lemere CAScience translational medicineComplement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice. Sci Transl Med. 2017 05 31; 9(392).Sci Transl Med2017-05-31T00:00:002017Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice.16543131Ishibashi T, Dakin KA, Stevens B, Lee PR, Kozlov SV, Stewart CL, Fields RDNeuronAstrocytes promote myelination in response to electrical impulses. Neuron. 2006 Mar 16; 49(6):823-32.Neuron2006-03-16T00:00:002006Astrocytes promote myelination in response to electrical impulses.SM596SamuelMarshSamuel Marsh, Ph.D.162780Marsh, SamuelResearch Fellow in Neurology2027-06-30CARROLL, MICHAEL CRAIG;STEVENS, BETH ANN2017-05-15Neural-immune Mechanisms and Synaptic Connectivity in Psychiatric IllnessP50MH112491Authorship 1011206228886007Salter MW, Stevens BNature medicineMicroglia emerge as central players in brain disease. Nat Med. 2017 Sep 08; 23(9):1018-1027.Nat Med2017-09-08T00:00:002017Microglia emerge as central players in brain disease.20711708Rosen AM, Stevens BAdvances in experimental medicine and biologyThe role of the classical complement cascade in synapse loss during development and glaucoma. Adv Exp Med Biol. 2010; 703:75-93.Adv Exp Med Biol2010-01-01T00:00:002010The role of the classical complement cascade in synapse loss during development and glaucoma.Authorship 1014338428951447Schecter RW, Maher EE, Welsh CA, Stevens B, Erisir A, Bear MFThe Journal of neuroscience : the official journal of the Society for NeuroscienceExperience-Dependent Synaptic Plasticity in V1 Occurs without Microglial CX3CR1. J Neurosci. 2017 11 01; 37(44):10541-10553.J Neurosci2017-09-26T00:00:002017Experience-Dependent Synaptic Plasticity in V1 Occurs without Microglial CX3CR1.23058800Bialas AR, Stevens BCurrent biology : CBGlia: regulating synaptogenesis from multiple directions. Curr Biol. 2012 Oct 09; 22(19):R833-5.Curr Biol2012-10-09T00:00:002012Glia: regulating synaptogenesis from multiple directions.Authorship 1016582228978423Hong S, Stevens BCell metabolismTREM2: Keeping Microglia Fit during Good Times and Bad. Cell Metab. 2017 Oct 03; 26(4):590-591.Cell Metab2017-10-03T00:00:002017TREM2: Keeping Microglia Fit during Good Times and Bad.300 Longwood AveChildrens HospitalKirby Ctr - CLS 12257300 Longwood AveBoston02115MA21490218Blank M, Fuerst PG, Stevens B, Nouri N, Kirkby L, Warrier D, Barres BA, Feller MB, Huberman AD, Burgess RW, Garner CCThe Journal of neuroscience : the official journal of the Society for NeuroscienceThe Down syndrome critical region regulates retinogeniculate refinement. J Neurosci. 2011 Apr 13; 31(15):5764-76.J Neurosci2011-04-13T00:00:002011The Down syndrome critical region regulates retinogeniculate refinement.22829357Schafer DP, Lehrman EK, Stevens BGliaThe "quad-partite" synapse: microglia-synapse interactions in the developing and mature CNS. Glia. 2013 Jan; 61(1):24-36.Glia2012-07-24T00:00:002012The "quad-partite" synapse: microglia-synapse interactions in the developing and mature CNS.12814563Stevens BCurrent biology : CBGlia: much more than the neuron's side-kick. Curr Biol. 2003 Jun 17; 13(12):R469-72.Curr Biol2003-06-17T00:00:002003Glia: much more than the neuron's side-kick.21383504Howell GR, Macalinao DG, Sousa GL, Walden M, Soto I, Kneeland SC, Barbay JM, King BL, Marchant JK, Hibbs M, Stevens B, Barres BA, Clark AF, Libby RT, John SWThe Journal of clinical investigationMolecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma. J Clin Invest. 2011 Apr; 121(4):1429-44.J Clin Invest2011-03-07T00:00:002011Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma.21903801Ransohoff RM, Stevens BScience (New York, N.Y.)Neuroscience. How many cell types does it take to wire a brain? Science. 2011 Sep 09; 333(6048):1391-2.Science2011-09-09T00:00:002011Neuroscience. How many cell types does it take to wire a brain?Authorship 1031419229246369Lloyd AC, Stevens BCurrent opinion in neurobiologyEditorial overview: Glial biology. Curr Opin Neurobiol. 2017 12; 47:iv-vi.Curr Opin Neurobiol2017-12-01T00:00:002017Editorial overview: Glial biology.20298206Schafer DP, Stevens BBiochemical Society transactionsSynapse elimination during development and disease: immune molecules take centre stage. Biochem Soc Trans. 2010 Apr; 38(2):476-81.Biochem Soc Trans2010-04-01T00:00:002010Synapse elimination during development and disease: immune molecules take centre stage.12467589Stevens B, Porta S, Haak LL, Gallo V, Fields RDNeuronAdenosine: a neuron-glial transmitter promoting myelination in the CNS in response to action potentials. Neuron. 2002 Dec 05; 36(5):855-68.Neuron2002-12-05T00:00:002002Adenosine: a neuron-glial transmitter promoting myelination in the CNS in response to action potentials.