NM24NavidMadaniNavid Madani, Ph.D.42.33789600000000-71.107249300000008623Madani, Navid617/632-3994Research Associate in Microbiologycatalyst:advisorInMentoringCompletedStudentProjectcompleted student projectscatalyst:eCommonsLogineCommons LoginMentoring - Completed Student Projectprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:address2address line 2vivo:address3address line 3vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:overviewoverviewvivo:personInPositionpositionsvivo:phoneNumberphonePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofvivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonAuthorship 10514882Authorship 1052946129524947Karamouzian M, Madani N, Doroudi F, Haghdoost AAInternational journal of health policy and managementTackling HIV in MENA: Talk Is Not Enough-It Is Time for Bold Actions: A Response to Recent Commentaries. Int J Health Policy Manag. 2018 02 01; 7(2):199-200.Int J Health Policy Manag2018-02-01T00:00:002018Tackling HIV in MENA: Talk Is Not Enough-It Is Time for Bold Actions: A Response to Recent Commentaries.29504249Madani NJournal of the International AIDS SocietyGender equality is crucial to the fight for better HIV treatment access and outcomes in the MENA region. J Int AIDS Soc. 2018 03; 21(3).J Int AIDS Soc2018-03-01T00:00:002018Gender equality is crucial to the fight for better HIV treatment access and outcomes in the MENA region.Authorship 10566958Authorship 1056056529618643Castillo-Menendez LR, Witt K, Espy N, Princiotto A, Madani N, Pacheco B, Finzi A, Sodroski JJournal of virologyComparison of Uncleaved and Mature Human Immunodeficiency Virus Membrane Envelope Glycoprotein Trimers. J Virol. 2018 06 15; 92(12).J Virol2018-05-29T00:00:002018Comparison of Uncleaved and Mature Human Immunodeficiency Virus Membrane Envelope Glycoprotein Trimers.29617845Princiotto AM, Vrbanac VD, Melillo B, Park J, Tager AM, Smith AB, Sodroski J, Madani NThe Journal of infectious diseasesA Small-Molecule CD4-Mimetic Compound Protects Bone Marrow-Liver-Thymus Humanized Mice From HIV-1 Infection. J Infect Dis. 2018 07 02; 218(3):471-475.J Infect Dis2018-07-02T00:00:002018A Small-Molecule CD4-Mimetic Compound Protects Bone Marrow-Liver-Thymus Humanized Mice From HIV-1 Infection.18402432Gopi H, Umashankara M, Pirrone V, LaLonde J, Madani N, Tuzer F, Baxter S, Zentner I, Cocklin S, Jawanda N, Miller SR, Schön A, Klein JC, Freire E, Krebs FC, Smith AB, Sodroski J, Chaiken IJournal of medicinal chemistryStructural determinants for affinity enhancement of a dual antagonist peptide entry inhibitor of human immunodeficiency virus type-1. J Med Chem. 2008 May 08; 51(9):2638-47.J Med Chem2008-04-11T00:00:002008Structural determinants for affinity enhancement of a dual antagonist peptide entry inhibitor of human immunodeficiency virus type-1.Authorship 113613223426315Modjarrad K, Mohraz M, Madani NNatureAIDS epidemic: Iran needs global support to fight HIV. Nature. 2013 Feb 21; 494(7437):314.Nature2013-02-21T00:00:002013AIDS epidemic: Iran needs global support to fight HIV.Authorship 1073715129915222Madani N, Princiotto AM, Mach L, Ding S, Prevost J, Richard J, Hora B, Sutherland L, Zhao CA, Conn BP, Bradley T, Moody MA, Melillo B, Finzi A, Haynes BF, Smith Iii AB, Santra S, Sodroski JNature communicationsA CD4-mimetic compound enhances vaccine efficacy against stringent immunodeficiency virus challenge. Nat Commun. 2018 06 18; 9(1):2363.Nat Commun2018-06-18T00:00:002018A CD4-mimetic compound enhances vaccine efficacy against stringent immunodeficiency virus challenge.15857992Xiang SH, Farzan M, Si Z, Madani N, Wang L, Rosenberg E, Robinson J, Sodroski JJournal of virologyFunctional mimicry of a human immunodeficiency virus type 1 coreceptor by a neutralizing monoclonal antibody. J Virol. 2005 May; 79(10):6068-77.J Virol2005-05-01T00:00:002005Functional mimicry of a human immunodeficiency virus type 1 coreceptor by a neutralizing monoclonal antibody.16335916Dong CZ, Kumar S, Choi WT, Madani N, Tian S, An J, Sodroski JG, Huang ZJournal of medicinal chemistryDifferent stereochemical requirements for CXCR4 binding and signaling functions as revealed by an anti-HIV, D-amino acid-containing SMM-chemokine ligand. J Med Chem. 2005 Dec 15; 48(25):7923-4.J Med Chem2005-12-15T00:00:002005Different stereochemical requirements for CXCR4 binding and signaling functions as revealed by an anti-HIV, D-amino acid-containing SMM-chemokine ligand.Authorship 1089758330129774Alipour Darvishi Z, Doroudi F, Madani NAIDS research and human retrovirusesFuzzy Modeling of the Enactment of Stigma by Healthcare Personnel Toward People Living with HIV in the Frame of Counterfactual Thinking: A Mixed-Method Approach. AIDS Res Hum Retroviruses. 2018 09; 34(9):808-815.AIDS Res Hum Retroviruses2018-09-01T00:00:002018Fuzzy Modeling of the Enactment of Stigma by Healthcare Personnel Toward People Living with HIV in the Frame of Counterfactual Thinking: A Mixed-Method Approach.22101518Dong CZ, Tian S, Madani N, Choi WT, Kumar S, Liu D, Sodroski JG, Huang Z, An JExperimental biology and medicine (Maywood, N.J.)Role of CXCR4 internalization in the anti-HIV activity of stromal cell-derived factor-1a probed by a novel synthetically and modularly modified-chemokine analog. Exp Biol Med (Maywood). 2011 Dec; 236(12):1413-9.Exp Biol Med (Maywood)2011-11-18T00:00:002011Role of CXCR4 internalization in the anti-HIV activity of stromal cell-derived factor-1a probed by a novel synthetically and modularly modified-chemokine analog.16943294Madani N, Hubicki AM, Perdigoto AL, Springer M, Sodroski JJournal of virologyInhibition of human immunodeficiency virus envelope glycoprotein- mediated single cell lysis by low-molecular-weight antagonists of viral entry. J Virol. 2007 Jan; 81(2):532-8.J Virol2006-08-30T00:00:002006Inhibition of human immunodeficiency virus envelope glycoprotein- mediated single cell lysis by low-molecular-weight antagonists of viral entry.22897429Choi WT, Kumar S, Madani N, Han X, Tian S, Dong CZ, Liu D, Duggineni S, Yuan J, Sodroski JG, Huang Z, An JBiochemistryA novel synthetic bivalent ligand to probe chemokine receptor CXCR4 dimerization and inhibit HIV-1 entry. Biochemistry. 2012 Sep 11; 51(36):7078-86.Biochemistry2012-08-29T00:00:002012A novel synthetic bivalent ligand to probe chemokine receptor CXCR4 dimerization and inhibit HIV-1 entry.Microbiology19000821Madani N, Schön A, Princiotto AM, Lalonde JM, Courter JR, Soeta T, Ng D, Wang L, Brower ET, Xiang SH, Kwon YD, Huang CC, Wyatt R, Kwong PD, Freire E, Smith AB, Sodroski JStructure (London, England : 1993)Small-molecule CD4 mimics interact with a highly conserved pocket on HIV-1 gp120. Structure. 2008 Nov 12; 16(11):1689-701.Structure2008-11-12T00:00:002008Small-molecule CD4 mimics interact with a highly conserved pocket on HIV-1 gp120.19343205Haim H, Si Z, Madani N, Wang L, Courter JR, Princiotto A, Kassa A, DeGrace M, McGee-Estrada K, Mefford M, Gabuzda D, Smith AB, Sodroski JPLoS pathogensSoluble CD4 and CD4-mimetic compounds inhibit HIV-1 infection by induction of a short-lived activated state. PLoS Pathog. 2009 Apr; 5(4):e1000360.PLoS Pathog2009-04-03T00:00:002009Soluble CD4 and CD4-mimetic compounds inhibit HIV-1 infection by induction of a short-lived activated state.22647699Kortagere S, Madani N, Mankowski MK, Schön A, Zentner I, Swaminathan G, Princiotto A, Anthony K, Oza A, Sierra LJ, Passic SR, Wang X, Jones DM, Stavale E, Krebs FC, Martín-García J, Freire E, Ptak RG, Sodroski J, Cocklin S, Smith ABJournal of virologyInhibiting early-stage events in HIV-1 replication by small-molecule targeting of the HIV-1 capsid. J Virol. 2012 Aug; 86(16):8472-81.J Virol2012-05-30T00:00:002012Inhibiting early-stage events in HIV-1 replication by small-molecule targeting of the HIV-1 capsid.D018716Physiology1422030.896422Molecular MimicryD015483Chemicals & Drugs22913090.588898HIV AntibodiesD015699Chemicals & Drugs1579470.688243HIV Envelope Protein gp120D015497Living Beings83469310.277707HIV-1D023581Chemicals & Drugs34830.935954HIV Fusion InhibitorsMedicinePathologyViral PathogenesisInfectious DiseaseOncologyVaccine ResearchBeth Israel Deaconess Medical CenterDana-Farber Cancer InstituteMassachusetts General HospitalJM105JarrodMartoJarrod Marto, Ph.D.42.33789600000000-71.107249300000001705Marto, JarrodAssociate Professor of PathologyMSS8MichaelSeamanMichael S. Seaman, Ph.D.42.34022770000000-71.1058540000000024231Seaman, MichaelAssociate Professor of MedicineKHM2KennethMayerKenneth Hugh Mayer, M.D.42.34652700000000-71.0878720000000068578Mayer, KennethProfessor of MedicineSS8SampaSantraSampa Santra, Ph.D.42.34022770000000-71.1058540000000087400Santra, SampaAssociate Professor of MedicineSA493SaumyaAnangSaumya Anang, Ph.D.179468Anang, SaumyaResearch Fellow in Microbiology1170selected publications3.260180.00380857215research areas6.103130.016860519coauthor of219.2249.8353260similar toDHB3DanBarouchDan Hung Barouch, M.D.42.34022770000000-71.1058540000000028268Barouch, DanWilliam Bosworth Castle Professor of MedicineREB26RachelleBernackiRachelle Emily Bernacki, M.D.42.33789600000000-71.1072493000000018742Bernacki, RachelleAssociate Professor of MedicineGA25GalitAlterGalit Alter, Ph.D.42.37730000000000-71.0525000000000083846Alter, GalitProfessor of Medicine (on leave)JGS10JosephSodroskiJoseph Gerard Sodroski, M.D.42.33789600000000-71.1072493000000042351Sodroski, JosephProfessor of MicrobiologySMT9SaraTolaneySara Michell Tolaney, M.D.42.33789600000000-71.1072493000000067909Tolaney, SaraAssociate Professor of MedicineTA15ToddAllenTodd Allen, Ph.D.42.37730000000000-71.0525000000000081018Allen, ToddProfessor of MedicineGL78Gwo-Shu MaryLeeGwo-Shu Mary Lee, Ph.D.42.33789600000000-71.1072493000000086170Lee, Gwo-Shu MaryResearch Associate in MedicineAuthorship 1304781Authorship 11800671431391272Zhao C, Princiotto AM, Nguyen HT, Zou S, Zhao ML, Zhang S, Herschhorn A, Farrell M, Pahil K, Melillo B, Sambasivarao SV, Abrams C, Smith AB, Madani N, Sodroski JJournal of virologyStrain-Dependent Activation and Inhibition of Human Immunodeficiency Virus Entry by a Specific PF-68742 Stereoisomer. J Virol. 2019 11 01; 93(21).J Virol2019-10-15T00:00:002019Strain-Dependent Activation and Inhibition of Human Immunodeficiency Virus Entry by a Specific PF-68742 Stereoisomer.Authorship 1340361true1Associate Professor of PathologyAssociate Professor of Pathologytrue1Research Associate in MedicineResearch Associate in Medicinetrue1Associate Professor of MedicineAssociate Professor of Medicinetrue1Professor of MedicineProfessor of Medicinetrue1Professor of MicrobiologyProfessor of Microbiologytrue1Research Associate in MicrobiologyResearch Associate in Microbiologytrue1Associate Professor of MedicineAssociate Professor of MedicineAuthorship 1277644Authorship 12311601532161177Zou S, Zhang S, Gaffney A, Ding H, Lu M, Grover JR, Farrell M, Nguyen HT, Zhao C, Anang S, Zhao M, Mohammadi M, Blanchard SC, Abrams C, Madani N, Mothes W, Kappes JC, Smith AB, Sodroski JJournal of virologyLong-Acting BMS-378806 Analogues Stabilize the State-1 Conformation of the Human Immunodeficiency Virus Type 1 Envelope Glycoproteins. J Virol. 2020 05 04; 94(10).J Virol2020-05-04T00:00:002020Long-Acting BMS-378806 Analogues Stabilize the State-1 Conformation of the Human Immunodeficiency Virus Type 1 Envelope Glycoproteins.Authorship 12490607Authorship 1246651232392227Joshi VR, Newman RM, Pack ML, Power KA, Munro JB, Okawa K, Madani N, Sodroski JG, Schmidt AG, Allen TMPLoS pathogensGp41-targeted antibodies restore infectivity of a fusion-deficient HIV-1 envelope glycoprotein. PLoS Pathog. 2020 05; 16(5):e1008577.PLoS Pathog2020-05-11T00:00:002020Gp41-targeted antibodies restore infectivity of a fusion-deficient HIV-1 envelope glycoprotein.32416767Karamouzian M, Madani NThe Lancet. Global healthCOVID-19 response in the Middle East and north Africa: challenges and paths forward. Lancet Glob Health. 2020 07; 8(7):e886-e887.Lancet Glob Health2020-05-14T00:00:002020COVID-19 response in the Middle East and north Africa: challenges and paths forward.Authorship 183383Authorship 1251630532457241Prévost J, Tolbert WD, Medjahed H, Sherburn RT, Madani N, Zoubchenok D, Gendron-Lepage G, Gaffney AE, Grenier MC, Kirk S, Vergara N, Han C, Mann BT, Chénine AL, Ahmed A, Chaiken I, Kirchhoff F, Hahn BH, Haim H, Abrams CF, Smith AB, Sodroski J, Pazgier M, Finzi AmBioThe HIV-1 Env gp120 Inner Domain Shapes the Phe43 Cavity and the CD4 Binding Site. mBio. 2020 05 26; 11(3).mBio2020-05-26T00:00:002020The HIV-1 Env gp120 Inner Domain Shapes the Phe43 Cavity and the CD4 Binding Site.true1Associate Professor of MedicineAssociate Professor of MedicineAuthorship 1314198533356641Aghila Rani KG, Hamad MA, Zaher DM, Sieburth SM, Madani N, Al-Tel THExpert opinion on drug discoveryDrug development post COVID-19 pandemic: toward a better system to meet current and future global health challenges. Expert Opin Drug Discov. 2021 04; 16(4):365-371.Expert Opin Drug Discov2020-12-28T00:00:002020Drug development post COVID-19 pandemic: toward a better system to meet current and future global health challenges.true1Associate Professor of MedicineAssociate Professor of MedicineAuthorship 1411159734795873Fritschi CJ, Liang S, Mohammadi M, Anang S, Moraca F, Chen J, Madani N, Sodroski JG, Abrams CF, Hendrickson WA, Smith ABACS medicinal chemistry lettersIdentification of gp120 Residue His105 as a Novel Target for HIV-1 Neutralization by Small-Molecule CD4-Mimics. ACS Med Chem Lett. 2021 Nov 11; 12(11):1824-1831.ACS Med Chem Lett2021-10-29T00:00:002021Identification of gp120 Residue His105 as a Novel Target for HIV-1 Neutralization by Small-Molecule CD4-Mimics.Authorship 15014941Authorship 1495690835980207Anang S, Richard J, Bourassa C, Goyette G, Chiu TJ, Chen HC, Smith AB, Madani N, Finzi A, Sodroski JJournal of virologyCharacterization of Human Immunodeficiency Virus (HIV-1) Envelope Glycoprotein Variants Selected for Resistance to a CD4-Mimetic Compound. J Virol. 2022 09 14; 96(17):e0063622.J Virol2022-08-18T00:00:002022Characterization of Human Immunodeficiency Virus (HIV-1) Envelope Glycoprotein Variants Selected for Resistance to a CD4-Mimetic Compound.36356158Madani NScience (New York, N.Y.)Be the voice for scientists in Iran. Science. 2022 11 11; 378(6620):578.Science2022-11-10T00:00:002022Be the voice for scientists in Iran.Authorship 151749911Authorship 1516317336660763Tayeri K, Asadollahi K, Madani N, Haghjooy Javanmard SAdvanced biomedical researchDoes COVID-19 Escalate Aging Process? A Possible Concern. Adv Biomed Res. 2022; 11:106.Adv Biomed Res2022-11-28T00:00:002022Does COVID-19 Escalate Aging Process? A Possible Concern.36655122Chaplain C, Fritschi CJ, Anang S, Gong Z, Richard J, Bourassa C, Liang S, Mohammadi M, Park J, Finzi A, Madani N, Sodroski JG, Abrams CF, Hendrickson WA, Smith ABACS medicinal chemistry lettersStructural and Functional Characterization of Indane-Core CD4-Mimetic Compounds Substituted with Heterocyclic Amines. ACS Med Chem Lett. 2023 Jan 12; 14(1):51-58.ACS Med Chem Lett2022-12-06T00:00:002022Structural and Functional Characterization of Indane-Core CD4-Mimetic Compounds Substituted with Heterocyclic Amines.Authorship 15335011336961924Fritschi CJ, Anang S, Gong Z, Mohammadi M, Richard J, Bourassa C, Severino KT, Richter H, Yang D, Chen HC, Chiu TJ, Seaman MS, Madani N, Abrams C, Finzi A, Hendrickson WA, Sodroski JG, Smith ABProceedings of the National Academy of Sciences of the United States of AmericaIndoline CD4-mimetic compounds mediate potent and broad HIV-1 inhibition and sensitization to antibody-dependent cellular cytotoxicity. Proc Natl Acad Sci U S A. 2023 03 28; 120(13):e2222073120.Proc Natl Acad Sci U S A2023-03-24T00:00:002023Indoline CD4-mimetic compounds mediate potent and broad HIV-1 inhibition and sensitization to antibody-dependent cellular cytotoxicity.Ragon Institute of MGH, MIT and Harvardtrue1Research Fellow in MicrobiologyResearch Fellow in Microbiologytrue1William Bosworth Castle Professor of MedicineWilliam Bosworth Castle Professor of MedicineAuthorship 15989652Authorship 1601243737888980Anang S, Zhang S, Fritschi C, Chiu T-J, Yang D, Smith Iii AB, Madani N, Sodroski JJournal of virologyV3 tip determinants of susceptibility to inhibition by CD4-mimetic compounds in natural clade A human immunodeficiency virus (HIV-1) envelope glycoproteins. J Virol. 2023 Nov 30; 97(11):e0117123.J Virol2023-10-27T00:00:002023V3 tip determinants of susceptibility to inhibition by CD4-mimetic compounds in natural clade A human immunodeficiency virus (HIV-1) envelope glycoproteins.37907635Rimawi R, Madani NNatureGaza's broken health-care system is compounding the risk of disease. Nature. 2023 Nov; 623(7985):32.Nature2023-11-01T00:00:002023Gaza's broken health-care system is compounding the risk of disease.true1Research Fellow in MedicineResearch Fellow in MedicineRu'aRimawiRu'a Rimawi, M.D.218386Rimawi, Ru'aResearch Fellow in MedicineAuthorship 2171292true1Professor of MedicineProfessor of Medicinetrue1Professor of Medicine (on leave)Professor of Medicine (on leave)Authorship 2503492Authorship 34723515Authorship 3264639Authorship 3877646Authorship 2571453Authorship 1955952Authorship 7250382Authorship 721202224629846Chahil-Graf R, Madani NJournal of the International AIDS SocietyWomen, culture and the HIV epidemic in MENA. J Int AIDS Soc. 2014; 17:19074.J Int AIDS Soc2014-03-08T00:00:002014Women, culture and the HIV epidemic in MENA.24502450Courter JR, Madani N, Sodroski J, Schön A, Freire E, Kwong PD, Hendrickson WA, Chaiken IM, LaLonde JM, Smith ABAccounts of chemical researchStructure-based design, synthesis and validation of CD4-mimetic small molecule inhibitors of HIV-1 entry: conversion of a viral entry agonist to an antagonist. Acc Chem Res. 2014 Apr 15; 47(4):1228-37.Acc Chem Res2014-02-06T00:00:002014Structure-based design, synthesis and validation of CD4-mimetic small molecule inhibitors of HIV-1 entry: conversion of a viral entry agonist to an antagonist.Authorship 4108252Authorship 753153124696475Madani N, Princiotto AM, Schön A, LaLonde J, Feng Y, Freire E, Park J, Courter JR, Jones DM, Robinson J, Liao HX, Moody MA, Permar S, Haynes B, Smith AB, Wyatt R, Sodroski JJournal of virologyCD4-mimetic small molecules sensitize human immunodeficiency virus to vaccine-elicited antibodies. J Virol. 2014 Jun; 88(12):6542-55.J Virol2014-04-02T00:00:002014CD4-mimetic small molecules sensitize human immunodeficiency virus to vaccine-elicited antibodies.Authorship 766260625357424Pancera M, Druz A, Zhou T, O'Dell S, Louder M, Madani N, Herschhorn A, Sodroski J, Mascola JR, Kwong PDAIDS research and human retrovirusesStructure of BMS-806, a Small-molecule HIV-1 Entry Inhibitor, Bound to BG505 SOSIP.664 HIV-1 Env Trimer. AIDS Res Hum Retroviruses. 2014 Oct; 30 Suppl 1:A151.AIDS Res Hum Retroviruses2014-10-01T00:00:002014Structure of BMS-806, a Small-molecule HIV-1 Entry Inhibitor, Bound to BG505 SOSIP.664 HIV-1 Env Trimer.Authorship 3889881Authorship 4146355Authorship 4762325Authorship 6044Authorship 708662Authorship 4581103Authorship 4791182Authorship 79507820Authorship 7909971225454268Tuyishime M, Danish M, Princiotto A, Mankowski MK, Lawrence R, Lombart HG, Esikov K, Berniac J, Liang K, Ji J, Ptak RG, Madani N, Cocklin SBioorganic & medicinal chemistry lettersDiscovery and optimization of novel small-molecule HIV-1 entry inhibitors using field-based virtual screening and bioisosteric replacement. Bioorg Med Chem Lett. 2014 Dec 01; 24(23):5439-45.Bioorg Med Chem Lett2014-12-01T00:00:002014Discovery and optimization of novel small-molecule HIV-1 entry inhibitors using field-based virtual screening and bioisosteric replacement.25941367Richard J, Veillette M, Brassard N, Iyer SS, Roger M, Martin L, Pazgier M, Schön A, Freire E, Routy JP, Smith AB, Park J, Jones DM, Courter JR, Melillo BN, Kaufmann DE, Hahn BH, Permar SR, Haynes BF, Madani N, Sodroski JG, Finzi AProceedings of the National Academy of Sciences of the United States of AmericaCD4 mimetics sensitize HIV-1-infected cells to ADCC. Proc Natl Acad Sci U S A. 2015 May 19; 112(20):E2687-94.Proc Natl Acad Sci U S A2015-05-04T00:00:002015CD4 mimetics sensitize HIV-1-infected cells to ADCC.Palliative CareAuthorship 3573052Authorship 639434Authorship 4092273Authorship 45169762006-08-15T00:00:002006-06-19T00:00:00Knowledge and Attitude of Iranian Dental Students towards HIV/AIDS in Tehran Universities
InternationalAuthorship 8692391Authorship 867210526816368Madani NScience (New York, N.Y.)Visa rules imperil collaboration. Science. 2016 Jan 15; 351(6270):234.Science2016-01-15T00:00:002016Visa rules imperil collaboration.26948920Gökengin D, Doroudi F, Tohme J, Collins B, Madani NInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious DiseasesHIV/AIDS: trends in the Middle East and North Africa region. Int J Infect Dis. 2016 Mar; 44:66-73.Int J Infect Dis2016-03-01T00:00:002016HIV/AIDS: trends in the Middle East and North Africa region.Authorship 8721611226985324Melillo B, Liang S, Park J, Schön A, Courter JR, LaLonde JM, Wendler DJ, Princiotto AM, Seaman MS, Freire E, Sodroski J, Madani N, Hendrickson WA, Smith ABACS medicinal chemistry lettersSmall-Molecule CD4-Mimics: Structure-Based Optimization of HIV-1 Entry Inhibition. ACS Med Chem Lett. 2016 Mar 10; 7(3):330-4.ACS Med Chem Lett2016-01-19T00:00:002016Small-Molecule CD4-Mimics: Structure-Based Optimization of HIV-1 Entry Inhibition.Authorship 879738126962221Madani N, Princiotto AM, Easterhoff D, Bradley T, Luo K, Williams WB, Liao HX, Moody MA, Phad GE, Vázquez Bernat N, Melillo B, Santra S, Smith AB, Karlsson Hedestam GB, Haynes B, Sodroski JJournal of virologyAntibodies Elicited by Multiple Envelope Glycoprotein Immunogens in Primates Neutralize Primary Human Immunodeficiency Viruses (HIV-1) Sensitized by CD4-Mimetic Compounds. J Virol. 2016 05 15; 90(10):5031-5046.J Virol2016-04-29T00:00:002016Antibodies Elicited by Multiple Envelope Glycoprotein Immunogens in Primates Neutralize Primary Human Immunodeficiency Viruses (HIV-1) Sensitized by CD4-Mimetic Compounds.Authorship 883306227012581Himmich H, Madani NThe International journal on drug policyThe state of harm reduction in the Middle East and North Africa: A focus on Iran and Morocco. Int J Drug Policy. 2016 05; 31:184-9.Int J Drug Policy2016-02-19T00:00:002016The state of harm reduction in the Middle East and North Africa: A focus on Iran and Morocco.Authorship 969612Authorship 889251227109106Gökengin D, Madani NInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious DiseasesResponse to letter to the editor re 'HIV Trends: Defining "The Middle East'. Int J Infect Dis. 2016 07; 48:124.Int J Infect Dis2016-04-22T00:00:002016Response to letter to the editor re 'HIV Trends: Defining "The Middle East'.1Associate Professor6Fellow or Post Doc0Full Professor5Other Faculty2012-05-31MADANI, NAVID2010-09-03Design of dendrimeric HIV-1 transmission inhibitors targeting gp120 Phe-43 cavityR56AI0906821900-01-01MADANI, NAVID2001-08-01Biophysical characterization of chemokine receptorsF32NS043260Principal InvestigatorPrincipal InvestigatorAuthorship 76991Authorship 4108163Authorship 92639912Authorship 928658627612593Bradley T, Trama A, Tumba N, Gray E, Lu X, Madani N, Jahanbakhsh F, Eaton A, Xia SM, Parks R, Lloyd KE, Sutherland LL, Scearce RM, Bowman CM, Barnett S, Abdool-Karim SS, Boyd SD, Melillo B, Smith AB, Sodroski J, Kepler TB, Alam SM, Gao F, Bonsignori M, Liao HX, Moody MA, Montefiori D, Santra S, Morris L, Haynes BFEBioMedicineAmino Acid Changes in the HIV-1 gp41 Membrane Proximal Region Control Virus Neutralization Sensitivity. EBioMedicine. 2016 Oct; 12:196-207.EBioMedicine2016-08-31T00:00:002016Amino Acid Changes in the HIV-1 gp41 Membrane Proximal Region Control Virus Neutralization Sensitivity.23667716Lalonde JM, Le-Khac M, Jones DM, Courter JR, Park J, Schön A, Princiotto AM, Wu X, Mascola JR, Freire E, Sodroski J, Madani N, Hendrickson WA, Smith ABACS medicinal chemistry lettersStructure-Based Design and Synthesis of an HIV-1 Entry Inhibitor Exploiting X-Ray and Thermodynamic Characterization. ACS Med Chem Lett. 2013 Mar 14; 4(3):338-343.ACS Med Chem Lett2013-03-14T00:00:002013Structure-Based Design and Synthesis of an HIV-1 Entry Inhibitor Exploiting X-Ray and Thermodynamic Characterization.Authorship 93574910Authorship 931200827846736Ding S, Verly MM, Princiotto A, Melillo B, Moody AM, Bradley T, Easterhoff D, Roger M, Hahn BH, Madani N, Smith AB, Haynes BF, Sodroski J, Finzi AAIDS research and human retrovirusesShort Communication: Small-Molecule CD4 Mimetics Sensitize HIV-1-Infected Cells to Antibody-Dependent Cellular Cytotoxicity by Antibodies Elicited by Multiple Envelope Glycoprotein Immunogens in Nonhuman Primates. AIDS Res Hum Retroviruses. 2017 05; 33(5):428-431.AIDS Res Hum Retroviruses2016-12-19T00:00:002016Short Communication: Small-Molecule CD4 Mimetics Sensitize HIV-1-Infected Cells to Antibody-Dependent Cellular Cytotoxicity by Antibodies Elicited by Multiple Envelope Glycoprotein Immunogens in Nonhuman Primates.27647452Ahani R, Roohvand F, Cohan RA, Etemadzadeh MH, Mohajel N, Behdani M, Shahosseini Z, Madani N, Azadmanesh KMolecular biotechnologySindbis Virus-Pseudotyped Lentiviral Vectors Carrying VEGFR2-Specific Nanobody for Potential Transductional Targeting of Tumor Vasculature. Mol Biotechnol. 2016 Nov; 58(11):738-747.Mol Biotechnol2016-11-01T00:00:002016Sindbis Virus-Pseudotyped Lentiviral Vectors Carrying VEGFR2-Specific Nanobody for Potential Transductional Targeting of Tumor Vasculature.Authorship 938410127881646Madani N, Princiotto AM, Zhao C, Jahanbakhshsefidi F, Mertens M, Herschhorn A, Melillo B, Smith AB, Sodroski JJournal of virologyActivation and Inactivation of Primary Human Immunodeficiency Virus Envelope Glycoprotein Trimers by CD4-Mimetic Compounds. J Virol. 2017 Feb 01; 91(3).J Virol2017-01-18T00:00:002017Activation and Inactivation of Primary Human Immunodeficiency Virus Envelope Glycoprotein Trimers by CD4-Mimetic Compounds.Authorship 940811828003492Pacheco B, Alsahafi N, Debbeche O, Prévost J, Ding S, Chapleau JP, Herschhorn A, Madani N, Princiotto A, Melillo B, Gu C, Zeng X, Mao Y, Smith AB, Sodroski J, Finzi AJournal of virologyResidues in the gp41 Ectodomain Regulate HIV-1 Envelope Glycoprotein Conformational Transitions Induced by gp120-Directed Inhibitors. J Virol. 2017 03 01; 91(5).J Virol2017-02-14T00:00:002017Residues in the gp41 Ectodomain Regulate HIV-1 Envelope Glycoprotein Conformational Transitions Induced by gp120-Directed Inhibitors.Authorship 662594Authorship 969285228209172Nguyen HT, Madani N, Ding H, Elder E, Princiotto A, Gu C, Darby P, Alin J, Herschhorn A, Kappes JC, Mao Y, Sodroski JGVirology journalEvaluation of the contribution of the transmembrane region to the ectodomain conformation of the human immunodeficiency virus (HIV-1) envelope glycoprotein. Virol J. 2017 02 16; 14(1):33.Virol J2017-02-16T00:00:002017Evaluation of the contribution of the transmembrane region to the ectodomain conformation of the human immunodeficiency virus (HIV-1) envelope glycoprotein.19535453Kassa A, Madani N, Schön A, Haim H, Finzi A, Xiang SH, Wang L, Princiotto A, Pancera M, Courter J, Smith AB, Freire E, Kwong PD, Sodroski JJournal of virologyTransitions to and from the CD4-bound conformation are modulated by a single-residue change in the human immunodeficiency virus type 1 gp120 inner domain. J Virol. 2009 Sep; 83(17):8364-78.J Virol2009-06-17T00:00:002009Transitions to and from the CD4-bound conformation are modulated by a single-residue change in the human immunodeficiency virus type 1 gp120 inner domain.15051887Si Z, Madani N, Cox JM, Chruma JJ, Klein JC, Schön A, Phan N, Wang L, Biorn AC, Cocklin S, Chaiken I, Freire E, Smith AB, Sodroski JGProceedings of the National Academy of Sciences of the United States of AmericaSmall-molecule inhibitors of HIV-1 entry block receptor-induced conformational changes in the viral envelope glycoproteins. Proc Natl Acad Sci U S A. 2004 Apr 06; 101(14):5036-41.Proc Natl Acad Sci U S A2004-03-29T00:00:002004Small-molecule inhibitors of HIV-1 entry block receptor-induced conformational changes in the viral envelope glycoproteins.14967033Biorn AC, Cocklin S, Madani N, Si Z, Ivanovic T, Samanen J, Van Ryk DI, Pantophlet R, Burton DR, Freire E, Sodroski J, Chaiken IMBiochemistryMode of action for linear peptide inhibitors of HIV-1 gp120 interactions. Biochemistry. 2004 Feb 24; 43(7):1928-38.Biochemistry2004-02-24T00:00:002004Mode of action for linear peptide inhibitors of HIV-1 gp120 interactions.16426973Kumar S, Choi WT, Dong CZ, Madani N, Tian S, Liu D, Wang Y, Pesavento J, Wang J, Fan X, Yuan J, Fritzsche WR, An J, Sodroski JG, Richman DD, Huang ZChemistry & biologySMM-chemokines: a class of unnatural synthetic molecules as chemical probes of chemokine receptor biology and leads for therapeutic development. Chem Biol. 2006 Jan; 13(1):69-79.Chem Biol2006-01-01T00:00:002006SMM-chemokines: a class of unnatural synthetic molecules as chemical probes of chemokine receptor biology and leads for therapeutic development.16306611Choi WT, Tian S, Dong CZ, Kumar S, Liu D, Madani N, An J, Sodroski JG, Huang ZJournal of virologyUnique ligand binding sites on CXCR4 probed by a chemical biology approach: implications for the design of selective human immunodeficiency virus type 1 inhibitors. J Virol. 2005 Dec; 79(24):15398-404.J Virol2005-12-01T00:00:002005Unique ligand binding sites on CXCR4 probed by a chemical biology approach: implications for the design of selective human immunodeficiency virus type 1 inhibitors.15016894Madani N, Perdigoto AL, Srinivasan K, Cox JM, Chruma JJ, LaLonde J, Head M, Smith AB, Sodroski JGJournal of virologyLocalized changes in the gp120 envelope glycoprotein confer resistance to human immunodeficiency virus entry inhibitors BMS-806 and #155. J Virol. 2004 Apr; 78(7):3742-52.J Virol2004-04-01T00:00:002004Localized changes in the gp120 envelope glycoprotein confer resistance to human immunodeficiency virus entry inhibitors BMS-806 and #155.Authorship 9824931028490588Johnson J, Zhai Y, Salimi H, Espy N, Eichelberger N, DeLeon O, O'Malley Y, Courter J, Smith AB, Madani N, Sodroski J, Haim HJournal of virologyInduction of a Tier-1-Like Phenotype in Diverse Tier-2 Isolates by Agents That Guide HIV-1 Env to Perturbation-Sensitive, Nonnative States. J Virol. 2017 08 01; 91(15).J Virol2017-07-12T00:00:002017Induction of a Tier-1-Like Phenotype in Diverse Tier-2 Isolates by Agents That Guide HIV-1 Env to Perturbation-Sensitive, Nonnative States.17686848Liu D, Madani N, Li Y, Cao R, Choi WT, Kawatkar SP, Lim MY, Kumar S, Dong CZ, Wang J, Russell JD, Lefebure CR, An J, Wilson S, Gao YG, Pallansch LA, Sodroski JG, Huang ZJournal of virologyCrystal structure and structural mechanism of a novel anti-human immunodeficiency virus and D-amino acid-containing chemokine. J Virol. 2007 Oct; 81(20):11489-98.J Virol2007-08-08T00:00:002007Crystal structure and structural mechanism of a novel anti-human immunodeficiency virus and D-amino acid-containing chemokine.16953583Schön A, Madani N, Klein JC, Hubicki A, Ng D, Yang X, Smith AB, Sodroski J, Freire EBiochemistryThermodynamics of binding of a low-molecular-weight CD4 mimetic to HIV-1 gp120. Biochemistry. 2006 Sep 12; 45(36):10973-80.Biochemistry2006-09-12T00:00:002006Thermodynamics of binding of a low-molecular-weight CD4 mimetic to HIV-1 gp120.12368356Madani N, Millette R, Platt EJ, Marin M, Kozak SL, Bloch DB, Kabat DJournal of virologyImplication of the lymphocyte-specific nuclear body protein Sp140 in an innate response to human immunodeficiency virus type 1. J Virol. 2002 Nov; 76(21):11133-8.J Virol2002-11-01T00:00:002002Implication of the lymphocyte-specific nuclear body protein Sp140 in an innate response to human immunodeficiency virus type 1.20967243Zhukovsky MA, Basmaciogullari S, Pacheco B, Wang L, Madani N, Haim H, Sodroski JPloS oneThermal stability of the human immunodeficiency virus type 1 (HIV-1) receptors, CD4 and CXCR4, reconstituted in proteoliposomes. PLoS One. 2010 Oct 13; 5(10):e13249.PLoS One2010-10-13T00:00:002010Thermal stability of the human immunodeficiency virus type 1 (HIV-1) receptors, CD4 and CXCR4, reconstituted in proteoliposomes.21731494Haim H, Strack B, Kassa A, Madani N, Wang L, Courter JR, Princiotto A, McGee K, Pacheco B, Seaman MS, Smith AB, Sodroski JPLoS pathogensContribution of intrinsic reactivity of the HIV-1 envelope glycoproteins to CD4-independent infection and global inhibitor sensitivity. PLoS Pathog. 2011 Jun; 7(6):e1002101.PLoS Pathog2011-06-23T00:00:002011Contribution of intrinsic reactivity of the HIV-1 envelope glycoproteins to CD4-independent infection and global inhibitor sensitivity.Authorship 100636716Authorship 1007623228825711Pancera M, Lai YT, Bylund T, Druz A, Narpala S, O'Dell S, Schön A, Bailer RT, Chuang GY, Geng H, Louder MK, Rawi R, Soumana DI, Finzi A, Herschhorn A, Madani N, Sodroski J, Freire E, Langley DR, Mascola JR, McDermott AB, Kwong PDNature chemical biologyCrystal structures of trimeric HIV envelope with entry inhibitors BMS-378806 and BMS-626529. Nat Chem Biol. 2017 Oct; 13(10):1115-1122.Nat Chem Biol2017-08-21T00:00:002017Crystal structures of trimeric HIV envelope with entry inhibitors BMS-378806 and BMS-626529.28812781Karamouzian M, Madani N, Doroudi F, Haghdoost AAInternational journal of health policy and managementImproving the Quality and Quantity of HIV Data in the Middle East and North Africa: Key Challenges and Ways Forward. Int J Health Policy Manag. 2017 02 01; 6(2):65-69.Int J Health Policy Manag2017-02-01T00:00:002017Improving the Quality and Quantity of HIV Data in the Middle East and North Africa: Key Challenges and Ways Forward.2022-06-30MADANI, NAVID2017-07-14Prevention of HIV-1 transmission by small-molecule CD4-mimetic entry inhibitorsR01AI134494Principal Investigator44 Binney StDana Farber Cancer InstituteJFB 608, Cancer Immunol/Aids44 Binney StBoston02115MA20660316Bird GH, Madani N, Perry AF, Princiotto AM, Supko JG, He X, Gavathiotis E, Sodroski JG, Walensky LDProceedings of the National Academy of Sciences of the United States of AmericaHydrocarbon double-stapling remedies the proteolytic instability of a lengthy peptide therapeutic. Proc Natl Acad Sci U S A. 2010 Aug 10; 107(32):14093-8.Proc Natl Acad Sci U S A2010-07-21T00:00:002010Hydrocarbon double-stapling remedies the proteolytic instability of a lengthy peptide therapeutic.21169023Lalonde JM, Elban MA, Courter JR, Sugawara A, Soeta T, Madani N, Princiotto AM, Kwon YD, Kwong PD, Schön A, Freire E, Sodroski J, Smith ABBioorganic & medicinal chemistryDesign, synthesis and biological evaluation of small molecule inhibitors of CD4-gp120 binding based on virtual screening. Bioorg Med Chem. 2011 Jan 01; 19(1):91-101.Bioorg Med Chem2010-11-26T00:00:002010Design, synthesis and biological evaluation of small molecule inhibitors of CD4-gp120 binding based on virtual screening.21288305Schön A, Madani N, Smith AB, Lalonde JM, Freire EChemical biology & drug designSome binding-related drug properties are dependent on thermodynamic signature. Chem Biol Drug Des. 2011 Mar; 77(3):161-5.Chem Biol Drug Des2011-02-02T00:00:002011Some binding-related drug properties are dependent on thermodynamic signature.21862123Malavia NK, Zurakowski D, Schroeder A, Princiotto AM, Laury AR, Barash HE, Sodroski J, Langer R, Madani N, Kohane DSBiomaterialsLiposomes for HIV prophylaxis. Biomaterials. 2011 Nov; 32(33):8663-8.Biomaterials2011-09-08T00:00:002011Liposomes for HIV prophylaxis.22497421LaLonde JM, Kwon YD, Jones DM, Sun AW, Courter JR, Soeta T, Kobayashi T, Princiotto AM, Wu X, Schön A, Freire E, Kwong PD, Mascola JR, Sodroski J, Madani N, Smith ABJournal of medicinal chemistryStructure-based design, synthesis, and characterization of dual hotspot small-molecule HIV-1 entry inhibitors. J Med Chem. 2012 May 10; 55(9):4382-96.J Med Chem2012-04-23T00:00:002012Structure-based design, synthesis, and characterization of dual hotspot small-molecule HIV-1 entry inhibitors.23011758Tuzer F, Madani N, Kamanna K, Zentner I, LaLonde J, Holmes A, Upton E, Rajagopal S, McFadden K, Contarino M, Sodroski J, Chaiken IProteinsHIV-1 Env gp120 structural determinants for peptide triazole dual receptor site antagonism. Proteins. 2013 Feb; 81(2):271-90.Proteins2012-10-26T00:00:002012HIV-1 Env gp120 structural determinants for peptide triazole dual receptor site antagonism.12767984LaBonte JA, Madani N, Sodroski JJournal of virologyCytolysis by CCR5-using human immunodeficiency virus type 1 envelope glycoproteins is dependent on membrane fusion and can be inhibited by high levels of CD4 expression. J Virol. 2003 Jun; 77(12):6645-59.J Virol2003-06-01T00:00:002003Cytolysis by CCR5-using human immunodeficiency virus type 1 envelope glycoproteins is dependent on membrane fusion and can be inhibited by high levels of CD4 expression.