SAF2StuartFormanStuart A. Forman, M.D.,Ph.D.42.36241700000000-71.0689370000000082192Forman, StuartA.Basic research is a major part of my career, currently accounting for about 70-75% of my total effort. For nearly two decades, my research has focused on the mechanisms responsible for general anesthesia, particularly their actions at fast neurotransmitter-gated ion channels, which are responsible for neuron-to-neuron synaptic communication. Currently, my lab is studying anesthetic actions on both nicotinic acetylcholine receptors, which are responsible for excitatory transmission in nerve and muscle, and gamma-aminobutyric acid type-A receptors, which are responsible for inhibitory neurotransmission in the brain and spinal cord. To investigate both how and where anesthetics affect the function of these ion channels, my research combines electrophysiological techniques with recombinant ion channel expression. I have pioneered advances in ultrafast superfusion of excised patches and patch-clamp electrophysiology by developing methods and building equipment for sub-millisecond switching among up to four independent flowing superfusates in an "artificial synapse." This advance has enabled demonstration of novel mechanisms of drug action. By creating mutations in specific protein regions of recombinantly expressed ion channels in living cells, my research has tested hypotheses about sites of anesthetic action. I was the first investigator to provide solid evidence for such a site on a ligand-gated ion channel, and the rigorous demonstration of these sites on receptors in brain remains a major thrust of my current research. My current research also includes collaborative projects with scientific colleagues in and outside my department. My research has been funded by the Foundation for Anesthesia Education and Research, the Medical Foundation/Charles King Trust, as well as a Scientist Training Award (K21) and Individual (P01/R01) Awards from the National Institutes of Health. I have been invited to present my research at regional, national, and international meetings. In 2004 I was awarded a Presidential Early Career Award for Scientists and Engineers (PECASE) for my research. I serve as an ad hoc reviewer for a number of scientific journals. As a member of the Dept. of Anesthesia Executive Committee on Research and the Beecher/Mallincrodt Research Laboratories Executive Committee, I have dedicated time to encouraging and supervising research activities within our department and mentoring young researchers, including students, residents, and research fellows.
From 1995 through 2002, I was responsible for coordinating "Ten Minutes of Science", presented along with Dept. of Anesthesia & Critical Care Case Conferences and Grand Rounds on Thursday mornings. This program was presented weekly from 1995-99, and bi-monthly thereafter and provides a forum for basic and clinical researchers working within the department to keep colleagues up to date on their progress. Currently, I chair the DACC Grand Rounds Steering Committee, which is responsible for setting a departmental educational agenda, and recruiting speakers to our weekly Grand Rounds. As a staff anesthesiologist, I supervise, teach, and evaluate residents and medical students who are rotating through the operating rooms of the Massachusetts General Hospital. Each year, I dedicate two weeks to tutoring a new first year Clinical Anesthesia resident, usually during their critical first two weeks of residency. I also act as clinical advisor and career advisor to residents in Anesthesiology, particularly those with strong interests in academic research careers. I have extended my mentoring activities to advising and guiding undergraduates at MIT who are planning careers in medicine. My specific areas of teaching expertise, which I have been invited to speak on both at departmental didactic lectures, other clinical departments, and at Harvard Medical School CME courses, include How Anesthesia Works, Awareness During General Anesthesia, Thermoregulation and its Anesthetic Impact, and Basic and Clinical Pharmacology of Nitrous Oxide. By participating as an examiner in mock oral exams, I have also helped prepare senior residents from the Harvard Teaching Hospitals for their oral board examinations.
As Staff Administrator of the MGH ORs several days each month, I am responsible for the deployment of over 100 Anesthesia personnel (staff, residents, and CRNAs) and efficient management of OR time in over 50 anesthetizing locations. I am also a member of the DACC Quality Assurance Committee, which reviews reports of actual or potential harm to patients associated with anesthetics administered in our department and decides how best to prevent such incidents. As a member of the General Surgery Anesthesia Team one day per week, I provide anesthesia care for patients undergoing a wide range of surgical procedures. These are frequently critically ill patients from various intensive care units at Mass. General Hospital or trauma patients from the emergency ward. The range of procedures includes thoracic and major vascular as well as neurosurgery, orthopedic surgery, and cancer surgery. Combined epidural and general anesthesia cases are my clinical forte.617/724-5156Professor of Anaesthesiacatalyst:eCommonsLogineCommons Loginprns:awardConferredByaward conferred byprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:address2address line 2vivo:address3address line 3vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipvivo:awardOrHonorawards and honorsAward or Honor ReceiptDepartmentDivisionGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:middleNamemiddle name or initialvivo:overviewoverviewvivo:personInPositionpositionsvivo:phoneNumberphonePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofvivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson11465549Scheller M, Forman SAAnesthesiologyThe gamma subunit determines whether anesthetic-induced leftward shift is altered by a mutation at alpha1S270 in alpha1beta2gamma2L GABA(A) receptors. Anesthesiology. 2001 Jul; 95(1):123-31.Anesthesiology2001-07-01T00:00:002001The gamma subunit determines whether anesthetic-induced leftward shift is altered by a mutation at alpha1S270 in alpha1beta2gamma2L GABA(A) receptors.4074663Forman SA, Verkman AS, Dix JA, Solomon AKBiochemistryn-Alkanols and halothane inhibit red cell anion transport and increase band 3 conformational change rate. Biochemistry. 1985 Aug 27; 24(18):4859-66.Biochemistry1985-08-27T00:00:001985n-Alkanols and halothane inhibit red cell anion transport and increase band 3 conformational change rate.Forman SA, Culley DJClinical Anesthesia Procedures of the Massachusetts General Hospital--Hurford WE, Bailin MT, Davison JK, Haspel KL, Rosow C, eds. Administration of General Anesthesia. Clinical Anesthesia Procedures of the Massachusetts General Hospital--Hurford WE, Bailin MT, Davison JK, Haspel KL, Rosow C, eds. 1998; 223-232.1998-01-01T00:00:001998Administration of General AnesthesiaForman SA, Zhou QBiophysical J.Curare agonism in nAChR: asymmetric forces on M2 domains. Biophysical J. 2000; 78:359A.2000-02-01T00:00:002000Curare agonism in nAChR: asymmetric forces on M2 domainsForman SA, Zhou Q.Alcoholism Leftward Shift of ACh concentration-response curves by ethanol is unaffected by nAChR pore mutations. Alcoholism. 1998; 22:47A .1998-06-01T00:00:001998Leftward Shift of ACh concentration-response curves by ethanol is unaffected by nAChR pore mutationsStuart A. FormanBasic and Systemic Mechanisms of Anesthesia Equilibrium and Kinetic Allosteric Mechanisms for Anesthetic and Structure Function Studies of GABA-A Receptors
. Basic and Systemic Mechanisms of Anesthesia. 2005; (ICS 5886).2005-08-01T00:00:002005Equilibrium and Kinetic Allosteric Mechanisms for Anesthetic and Structure Function Studies of GABA-A Receptors
19218367Chiara DC, Hong FH, Arevalo E, Husain SS, Miller KW, Forman SA, Cohen JBMolecular pharmacologyTime-resolved photolabeling of the nicotinic acetylcholine receptor by [3H]azietomidate, an open-state inhibitor. Mol Pharmacol. 2009 May; 75(5):1084-95.Mol Pharmacol2009-02-13T00:00:002009Time-resolved photolabeling of the nicotinic acetylcholine receptor by [3H]azietomidate, an open-state inhibitor.15016806Rüsch D, Zhong H, Forman SAThe Journal of biological chemistryGating allosterism at a single class of etomidate sites on alpha1beta2gamma2L GABA A receptors accounts for both direct activation and agonist modulation. J Biol Chem. 2004 May 14; 279(20):20982-92.J Biol Chem2004-03-11T00:00:002004Gating allosterism at a single class of etomidate sites on alpha1beta2gamma2L GABA A receptors accounts for both direct activation and agonist modulation.20662008Dostalova Z, Liu A, Zhou X, Farmer SL, Krenzel ES, Arevalo E, Desai R, Feinberg-Zadek PL, Davies PA, Yamodo IH, Forman SA, Miller KWProtein science : a publication of the Protein SocietyHigh-level expression and purification of Cys-loop ligand-gated ion channels in a tetracycline-inducible stable mammalian cell line: GABAA and serotonin receptors. Protein Sci. 2010 Sep; 19(9):1728-38.Protein Sci2010-09-01T00:00:002010High-level expression and purification of Cys-loop ligand-gated ion channels in a tetracycline-inducible stable mammalian cell line: GABAA and serotonin receptors.Forman SA, Miller KW, Yellen G.Biophys. J. Hydrophobic mutations in the M2 domain of nicotinic ACh receptors modulate n-alcohol blocking potencies. Biophys. J. 1995; 68:A233.1995-02-01T00:00:001995Hydrophobic mutations in the M2 domain of nicotinic ACh receptors modulate n-alcohol blocking potenciesRuesch D, Forman SAAnesthesiology Benzodiazepines modulate the gating efficacy of α1β2γ2L GABAA Receptors. Anesthesiology. 2004.2004-10-01T00:00:002004Benzodiazepines modulate the gating efficacy of α1β2γ2L GABAA ReceptorsPratt MB, Forman SA, Husain SS, Dubois B, Kloczewiak MA, Addona GH, Yu J, Chiara DC, Cohen JB, Miller KWProgress in Anesthetic MechanismSites of Anesthetic Action on the Nicotinic Acetylcholine Receptor. Progress in Anesthetic Mechanism. 2000; 6:285-291.2000-01-01T00:00:002000Sites of Anesthetic Action on the Nicotinic Acetylcholine Receptor7476881Forman SA, Miller KW, Yellen GMolecular pharmacologyA discrete site for general anesthetics on a postsynaptic receptor. Mol Pharmacol. 1995 Oct; 48(4):574-81.Mol Pharmacol1995-10-01T00:00:001995A discrete site for general anesthetics on a postsynaptic receptor.18617817Forman SA, Chin VAInternational anesthesiology clinicsGeneral anesthetics and molecular mechanisms of unconsciousness. Int Anesthesiol Clin. 2008; 46(3):43-53.Int Anesthesiol Clin2008-01-01T00:00:002008General anesthetics and molecular mechanisms of unconsciousness.Authorship 1068230129588039Forman SAMethods in enzymologyCombining Mutations and Electrophysiology to Map Anesthetic Sites on Ligand-Gated Ion Channels. Methods Enzymol. 2018; 602:369-389.Methods Enzymol2018-02-28T00:00:002018Combining Mutations and Electrophysiology to Map Anesthetic Sites on Ligand-Gated Ion Channels.22531336Guitchounts G, Stewart DS, Forman SAAnesthesiologyTwo etomidate sites in a1ß2?2 ?-aminobutyric acid type A receptors contribute equally and noncooperatively to modulation of channel gating. Anesthesiology. 2012 Jun; 116(6):1235-44.Anesthesiology2012-06-01T00:00:002012Two etomidate sites in a1ß2?2 ?-aminobutyric acid type A receptors contribute equally and noncooperatively to modulation of channel gating.12351715Scheller M, Forman SAThe Journal of neuroscience : the official journal of the Society for NeuroscienceCoupled and uncoupled gating and desensitization effects by pore domain mutations in GABA(A) receptors. J Neurosci. 2002 Oct 01; 22(19):8411-21.J Neurosci2002-10-01T00:00:002002Coupled and uncoupled gating and desensitization effects by pore domain mutations in GABA(A) receptors.Authorship 10732401329894316Yang X, Jounaidi Y, Dai JB, Marte-Oquendo F, Halpin ES, Brown LE, Trilles R, Xu W, Daigle R, Yu B, Schaus SE, Porco JA, Forman SAAnesthesiologyHigh-throughput Screening in Larval Zebrafish Identifies Novel Potent Sedative-hypnotics. Anesthesiology. 2018 09; 129(3):459-476.Anesthesiology2018-09-01T00:00:002018High-throughput Screening in Larval Zebrafish Identifies Novel Potent Sedative-hypnotics.Forman SA, Miller KW, Raines DEJ.F. Biebuyck, C.Lynch III, M. Maze, L.J. Saidman, T.L Yaksh, W.M. Zapol, eds. Anesthesia: Biologic FoundationsInteractions of general anesthetics with membranes. J.F. Biebuyck, C.Lynch III, M. Maze, L.J. Saidman, T.L Yaksh, W.M. Zapol, eds. Anesthesia: Biologic Foundations. 1997; 5-18.1997-01-01T00:00:001997Interactions of general anesthetics with membranesRaines DE, Scheller M, Forman SA, Claycomb JMolecular and Basic Mechanisms of Anesthesia.Selective receptor actions of nonhalogenated alkane anesthetics. Molecular and Basic Mechanisms of Anesthesia. 2002; 163-164.2002-06-01T00:00:002002Selective receptor actions of nonhalogenated alkane anestheticsForman SA, Miller KW, Yellen G.AnesthesiologyGeneral Anesthetic Potency is Unaltered by Mutations in the M2 (Ion Channel) Domains of the Nicotinic Acetylcholine Receptor that Modulate Local Anesthetic Potency. Anesthesiology. 1994; 81(3A):A873.1994-10-01T00:00:001994General Anesthetic Potency is Unaltered by Mutations in the M2 (Ion Channel) Domains of the Nicotinic Acetylcholine Receptor that Modulate Local Anesthetic PotencyForman SA, Zhou Q.Alcoholism Scanning hydrophobic mutagenesis maps a discrete region of the nAChR pore that interacts with ethanol. Alcoholism. 1998; 22:46A .1998-06-01T00:00:001998Scanning hydrophobic mutagenesis maps a discrete region of the nAChR pore that interacts with ethanolForman SA, Ruesch DAnesthesiology Two etomidate actions in GABAA receptors are explained by a co-agonist mechanism. Anesthesiology. 2003.2003-10-01T00:00:002003Two etomidate actions in GABAA receptors are explained by a co-agonist mechanism22968919Stein M, Middendorp SJ, Carta V, Pejo E, Raines DE, Forman SA, Sigel E, Trauner DAngewandte Chemie (International ed. in English)Azo-propofols: photochromic potentiators of GABA(A) receptors. Angew Chem Int Ed Engl. 2012 Oct 15; 51(42):10500-4.Angew Chem Int Ed Engl2012-09-11T00:00:002012Azo-propofols: photochromic potentiators of GABA(A) receptors.Raines DE, Claycomb RJ, Scheller M, Forman SABiophysical J.Nonhalogenated alkane anesthetics fail to potentiate agonist actions on two ligand-gated ion channels at clinically relevant concentrations. Biophysical J. 2001; 80:103a.2001-02-01T00:00:002001Nonhalogenated alkane anesthetics fail to potentiate agonist actions on two ligand-gated ion channels at clinically relevant concentrationsClaycomb, RJ, Forman SA, Raines DEMolecular and Basic Mechanisms of AnesthesiaInhibition of alpha-4/beta-2 Rat Neuronal Nicotinic Receptors by Nonhalogenated Alkane Anesthetics and Perhalogenated Alkane Nonimmobilizers. Molecular and Basic Mechanisms of Anesthesia. 2002; 115-119.2002-01-01T00:00:002002Inhibition of alpha-4/beta-2 Rat Neuronal Nicotinic Receptors by Nonhalogenated Alkane Anesthetics and Perhalogenated Alkane Nonimmobilizers22029276Stewart DS, Savechenkov PY, Dostalova Z, Chiara DC, Ge R, Raines DE, Cohen JB, Forman SA, Bruzik KS, Miller KWJournal of medicinal chemistryp-(4-Azipentyl)propofol: a potent photoreactive general anesthetic derivative of propofol. J Med Chem. 2011 Dec 08; 54(23):8124-35.J Med Chem2011-11-10T00:00:002011p-(4-Azipentyl)propofol: a potent photoreactive general anesthetic derivative of propofol.3038165Forman SA, Firestone LL, Miller KWBiochemistryIs agonist self-inhibition at the nicotinic acetylcholine receptor a nonspecific action? Biochemistry. 1987 May 19; 26(10):2807-14.Biochemistry1987-05-19T00:00:001987Is agonist self-inhibition at the nicotinic acetylcholine receptor a nonspecific action?Forman SAAnesthesiologyRegions of the GABAA receptor gamma subunit affecting sensitivity to volatile agents. Anesthesiology. 2002.2002-10-01T00:00:002002Regions of the GABAA receptor gamma subunit affecting sensitivity to volatile agentsZhou Q, Forman SAAnesthesiologyIrreversible inhibition by photo-incorporation of anesthetic 3-azi-octanol in nicotinic acetylcholine receptors. Anesthesiology. 2001.2001-10-01T00:00:002001Irreversible inhibition by photo-incorporation of anesthetic 3-azi-octanol in nicotinic acetylcholine receptors2021-07-31FORMAN, STUART A2018-08-01Accelerating General Anesthetic Discovery and Mechanisms Research with ZebrafishR01GM128989Principal InvestigatorAuthorship 1151043Forman SA, Miller KW, Yellen GProceedings of 42nd Annual AUA MeetingGeneral anesthetics bind in the transmembrane pore of a neurotransmitter receptor protein. Proceedings of 42nd Annual AUA Meeting. 1995; 60-61.1995-05-01T00:00:001995General anesthetics bind in the transmembrane pore of a neurotransmitter receptor protein19625798Cotten JF, Husain SS, Forman SA, Miller KW, Kelly EW, Nguyen HH, Raines DEAnesthesiologyMethoxycarbonyl-etomidate: a novel rapidly metabolized and ultra-short-acting etomidate analogue that does not produce prolonged adrenocortical suppression. Anesthesiology. 2009 Aug; 111(2):240-9.Anesthesiology2009-08-01T00:00:002009Methoxycarbonyl-etomidate: a novel rapidly metabolized and ultra-short-acting etomidate analogue that does not produce prolonged adrenocortical suppression.2597688Forman SA, Righi DL, Miller KWBiochimica et biophysica actaEthanol increases agonist affinity for nicotinic receptors from Torpedo. Biochim Biophys Acta. 1989 Dec 11; 987(1):95-103.Biochim Biophys Acta1989-12-11T00:00:001989Ethanol increases agonist affinity for nicotinic receptors from Torpedo.Forman SAAnesthesia & AnalgesiaMolecular Bases of Anesthesia (Book review). Anesthesia & Analgesia. 2001; 93:806-807.2001-01-01T00:00:002001Molecular Bases of Anesthesia (Book review)Authorship 120439422614249Forman SACurrent opinion in anaesthesiologyMonod-Wyman-Changeux allosteric mechanisms of action and the pharmacology of etomidate. Curr Opin Anaesthesiol. 2012 Aug; 25(4):411-8.Curr Opin Anaesthesiol2012-08-01T00:00:002012Monod-Wyman-Changeux allosteric mechanisms of action and the pharmacology of etomidate.22734650Savechenkov PY, Zhang X, Chiara DC, Stewart DS, Ge R, Zhou X, Raines DE, Cohen JB, Forman SA, Miller KW, Bruzik KSJournal of medicinal chemistryAllyl m-trifluoromethyldiazirine mephobarbital: an unusually potent enantioselective and photoreactive barbiturate general anesthetic. J Med Chem. 2012 Jul 26; 55(14):6554-65.J Med Chem2012-07-17T00:00:002012Allyl m-trifluoromethyldiazirine mephobarbital: an unusually potent enantioselective and photoreactive barbiturate general anesthetic.23511525Forman SAAnesthesiologyA paradigm shift from biophysical to neurobiological: the fading influence of Claude Bernard's ideas about general anesthesia. Anesthesiology. 2013 Apr; 118(4):984-5.Anesthesiology2013-04-01T00:00:002013A paradigm shift from biophysical to neurobiological: the fading influence of Claude Bernard's ideas about general anesthesia.Zhong H, Ruesch D, Forman SAPhoto-activated azi-etomidate, a general anesthetic photolabel, irreversibly alters GABAA receptor function. Submitted. 2006.2006-01-01T00:00:002006Photo-activated azi-etomidate, a general anesthetic photolabel, irreversibly alters GABAA receptor function. SubmittedForman SAClinical Anesthesia Procedures of the Massachusetts General Hospital--Hurford WE, Bailin MT, Davison JK, Haspel KL, Rosow C, eds. Administration of General Anesthesia. Clinical Anesthesia Procedures of the Massachusetts General Hospital--Hurford WE, Bailin MT, Davison JK, Haspel KL, Rosow C, eds. 2002; 210-219.2002-01-01T00:00:002002Administration of General AnesthesiaForman SA, Ruesch DBiophysical J.Two general anesthetic actions in GABAARs are attributable to altered gating. Biophysical J. 2003; 81:A813.2003-02-01T00:00:002003Two general anesthetic actions in GABAARs are attributable to altered gatingStuart A. FormanMechanisms of General Anesthesia (Powerpoint Presentation and lecture notes)Mechanisms of General Anesthesia (Powerpoint Presentation and lecture notes). 1999.1999-02-01T00:00:001999Mechanisms of General Anesthesia (Powerpoint Presentation and lecture notes)Authorship 1110172430389723Liao Y, Liu X, Jounaidi Y, Forman SA, Feng HJThe Journal of pharmacology and experimental therapeuticsEtomidate Effects on Desensitization and Deactivation of a4ß3d GABAA Receptors Inducibly Expressed in HEK293 TetR Cells. J Pharmacol Exp Ther. 2019 01; 368(1):100-105.J Pharmacol Exp Ther2018-11-02T00:00:002018Etomidate Effects on Desensitization and Deactivation of a4ß3d GABAA Receptors Inducibly Expressed in HEK293 TetR Cells.9882703Forman SA, Zhou QMolecular pharmacologyNovel modulation of a nicotinic receptor channel mutant reveals that the open state is stabilized by ethanol. Mol Pharmacol. 1999 Jan; 55(1):102-8.Mol Pharmacol1999-01-01T00:00:001999Novel modulation of a nicotinic receptor channel mutant reveals that the open state is stabilized by ethanol.Forman SA.Anesthesiology Homologous Hydrophobic mutations in the nicotinic acetylcholine receptor alpha, beta and gamma subunit M2 domains contribute unequally but additively to anesthetic binding energy. Anesthesiology. 1996; 85 (3A):A686.1996-10-01T00:00:001996Homologous Hydrophobic mutations in the nicotinic acetylcholine receptor alpha, beta and gamma subunit M2 domains contribute unequally but additively to anesthetic binding energyStuart A. Forman and Dirk RueschBasic and Systemic Mechanisms of Anesthesia Interpreting the Impact of GABA-A Receptor Structural Modifications Using an Allosteric Co-Agonist Mechanism for Etomidate Actions
. Basic and Systemic Mechanisms of Anesthesia. 2005; (ICS 5886).2005-08-01T00:00:002005Interpreting the Impact of GABA-A Receptor Structural Modifications Using an Allosteric Co-Agonist Mechanism for Etomidate Actions
Forman SA Verkman AS Dix, JA, Solomon AK.Biophys. J.Effect of lipid perturbants on red cell band 3 conformational states. Biophys. J. 1982; 37:216a.1982-02-01T00:00:001982Effect of lipid perturbants on red cell band 3 conformational statesForman SA, Zhou QLMolecular and Basic Mechanisms of Anesthesia.Irreversible inhibition of nAChR by photo-incorporation of anesthetic 3-azioctanol. Molecular and Basic Mechanisms of Anesthesia. 2002; 126.2002-06-01T00:00:002002Irreversible inhibition of nAChR by photo-incorporation of anesthetic 3-azioctanolForman SA, Firestone LL, Miller KW.Biophys. JAgonist self-inhibition at the nicotinic receptor: additive effects of other inhibitors. Biophys. J. 1987; 51:62a.1987-02-01T00:00:001987Agonist self-inhibition at the nicotinic receptor: additive effects of other inhibitors7688196Alifimoff JK, Bugge B, Forman SA, Miller KWAnesthesiologyStereoselectivity of channel inhibition by secondary alkanol enantiomers at nicotinic acetylcholine receptors. Anesthesiology. 1993 Jul; 79(1):122-8.Anesthesiology1993-07-01T00:00:001993Stereoselectivity of channel inhibition by secondary alkanol enantiomers at nicotinic acetylcholine receptors.2481226Roth SH, Forman SA, Braswell LM, Miller KWMolecular pharmacologyActions of pentobarbital enantiomers on nicotinic cholinergic receptors. Mol Pharmacol. 1989 Dec; 36(6):874-80.Mol Pharmacol1989-12-01T00:00:001989Actions of pentobarbital enantiomers on nicotinic cholinergic receptors.20179500Cotten JF, Forman SA, Laha JK, Cuny GD, Husain SS, Miller KW, Nguyen HH, Kelly EW, Stewart D, Liu A, Raines DEAnesthesiologyCarboetomidate: a pyrrole analog of etomidate designed not to suppress adrenocortical function. Anesthesiology. 2010 Mar; 112(3):637-44.Anesthesiology2010-03-01T00:00:002010Carboetomidate: a pyrrole analog of etomidate designed not to suppress adrenocortical function.22543065Pierce DW, Pejo E, Raines DE, Forman SAAnesthesia and analgesiaCarboetomidate inhibits alpha4/beta2 neuronal nicotinic acetylcholine receptors at concentrations affecting animals. Anesth Analg. 2012 Jul; 115(1):70-2.Anesth Analg2012-04-27T00:00:002012Carboetomidate inhibits alpha4/beta2 neuronal nicotinic acetylcholine receptors at concentrations affecting animals.Ackerman JR, Forman SA, Hossain M, Kohler BEJournal of Chemical Physicss-cis Octatetraene: photoproduction and spectroscopic properties. Journal of Chemical Physics. 1984; 80:39-44.1984-01-01T00:00:001984s-cis Octatetraene: photoproduction and spectroscopic propertiesForman SA.Biophys. J.Ethanol interactions with nicotinic ACh receptor probed in an alcohol-sensitive mutant, alpha-S10'I+beta-T10'I. Biophys. J. 1997; 72 (2):A152.1997-02-01T00:00:001997Ethanol interactions with nicotinic ACh receptor probed in an alcohol-sensitive mutant, alpha-S10'I+beta-T10'IForman SA, Zhou QLAnesthesiologyMutation of an anesthetic-photolabeled residue in the nAChR pore alters sensitivity to GAs. Anesthesiology. 2000; 93(3A):A-774.2000-10-01T00:00:002000Mutation of an anesthetic-photolabeled residue in the nAChR pore alters sensitivity to GAsAuthorship 11223671030544077Wu B, Jayakar SS, Zhou X, Titterton K, Chiara DC, Szabo AL, Savechenkov PY, Kent DE, Cohen JB, Forman SA, Miller KW, Bruzik KSEuropean journal of medicinal chemistryInhibitable photolabeling by neurosteroid diazirine analog in the ß3-Subunit of human hetereopentameric type A GABA receptors. Eur J Med Chem. 2019 Jan 15; 162:810-824.Eur J Med Chem2018-11-19T00:00:002018Inhibitable photolabeling by neurosteroid diazirine analog in the ß3-Subunit of human hetereopentameric type A GABA receptors.Stuart A. FormanAwareness During General Anesthesia (Powerpoint Presentation and handout)Awareness During General Anesthesia (Powerpoint Presentation and handout). 2003.2003-03-01T00:00:002003Awareness During General Anesthesia (Powerpoint Presentation and handout)7126563Forman SA, Verkman AS, Dix JA, Solomon AKBiochimica et biophysica actaInteraction of phloretin with the anion transport protein of the red blood cell membrane. Biochim Biophys Acta. 1982 Aug 12; 689(3):531-8.Biochim Biophys Acta1982-08-12T00:00:001982Interaction of phloretin with the anion transport protein of the red blood cell membrane.15664985Arevalo E, Chiara DC, Forman SA, Cohen JB, Miller KWThe Journal of biological chemistryGating-enhanced accessibility of hydrophobic sites within the transmembrane region of the nicotinic acetylcholine receptor's {delta}-subunit. A time-resolved photolabeling study. J Biol Chem. 2005 Apr 08; 280(14):13631-40.J Biol Chem2005-01-21T00:00:002005Gating-enhanced accessibility of hydrophobic sites within the transmembrane region of the nicotinic acetylcholine receptor's {delta}-subunit. A time-resolved photolabeling study.18480181Jaureguiberry G, Carpenter TO, Forman S, Jüppner H, Bergwitz CAmerican journal of physiology. Renal physiologyA novel missense mutation in SLC34A3 that causes hereditary hypophosphatemic rickets with hypercalciuria in humans identifies threonine 137 as an important determinant of sodium-phosphate cotransport in NaPi-IIc. Am J Physiol Renal Physiol. 2008 Aug; 295(2):F371-9.Am J Physiol Renal Physiol2008-05-14T00:00:002008A novel missense mutation in SLC34A3 that causes hereditary hypophosphatemic rickets with hypercalciuria in humans identifies threonine 137 as an important determinant of sodium-phosphate cotransport in NaPi-IIc.21074751Forman SAAnesthesiology clinicsMolecular approaches to improving general anesthetics. Anesthesiol Clin. 2010 Dec; 28(4):761-71.Anesthesiol Clin2010-12-01T00:00:002010Molecular approaches to improving general anesthetics.Scheller M, Forman SABiophysical J.Two mutations in the GABAAR pore domain selectively alter deactivation and desensitization rates. Biophysical J. 2001; 80:107a.2001-02-01T00:00:002001Two mutations in the GABAAR pore domain selectively alter deactivation and desensitization ratesForman SA, Miller KWEthanol enhances, octanol and pentobarbital inhibit flux in Torpedo AChR vesicles. 1984.1984-06-01T00:00:001984Ethanol enhances, octanol and pentobarbital inhibit flux in Torpedo AChR vesiclesAuthorship 1129389430696720Szabo A, Nourmahnad A, Halpin E, Forman SAMolecular pharmacologyMonod-Wyman-Changeux Allosteric Shift Analysis in Mutant a1ß3?2L GABAA Receptors Indicates Selectivity and Crosstalk among Intersubunit Transmembrane Anesthetic Sites. Mol Pharmacol. 2019 04; 95(4):408-417.Mol Pharmacol2019-01-29T00:00:002019Monod-Wyman-Changeux Allosteric Shift Analysis in Mutant a1ß3?2L GABAA Receptors Indicates Selectivity and Crosstalk among Intersubunit Transmembrane Anesthetic Sites.D005045Chemicals & Drugs471900.809517EtomidateD000777Chemicals & Drugs2805360.630308Anesthetics30896593Shay D, Scheffenbichler FT, Kelly BJ, Lihn AL, Deng H, Nourmahnad A, Xu X, Houle TT, Eikermann M, Forman SAAnesthesia and analgesiaEffects of Anticholinesterase Reversal Under General Anesthesia on Postoperative Cardiovascular Complications: A Retrospective Cohort Study. Anesth Analg. 2020 03; 130(3):685-695.Anesth Analg2020-03-01T00:00:002020Effects of Anticholinesterase Reversal Under General Anesthesia on Postoperative Cardiovascular Complications: A Retrospective Cohort Study.Authorship 114133310D018686Chemicals & Drugs2334170.75385Anesthetics, IntravenousD011963Chemicals & Drugs2046270.695819Receptors, GABA-AD018681Chemicals & Drugs641520.848054Anesthetics, GeneralAuthorship 1170954AnaesthesiaEmeritusHarvard Medical SchoolMassachusetts General HospitalKWM1KeithMillerKeith Wyatt Miller42.36241700000000-71.0689370000000074878Miller, KeithMallinckrodt Professor of Pharmacology in the Department of Anaesthesia11163selected publications10.19520.00193642333research areas3.787830.034110320coauthor of236.45712.081260similar toZX1ZhongcongXieZhongcong Xie, M.D., Ph.D.42.36241700000000-71.0689370000000056895Xie, ZhongcongHenry Knowles Beecher Professor of AnaesthesiaVEM1VickiModestVicki E. Modest, M.D.42.36241700000000-71.0689370000000058953Modest, VickiAssistant Professor of Anaesthesia, Part-timeMM153MarkMeyerMark A Meyer, M.D.42.36241700000000-71.0689370000000052494Meyer, MarkLecturer on Anaesthesia, Part-timePLP1PatrickPurdonPatrick Lee Purdon, Ph.D.42.37730000000000-71.0525000000000069205Purdon, PatrickAssociate Professor of AnaesthesiaDER1DouglasRainesDouglas Eric Raines, M.D.42.36241700000000-71.0689370000000018942Raines, DouglasEdward Mallinckrodt, Jr. Professor of Anaesthesia in the Field Pharmacology and InnovationRD61RoomaDesaiRooma Desai, Ph.D.42.36241700000000-71.0689370000000039153Desai, RoomaInstructor in AnaesthesiaAZ47AudriusZibaitisAudrius Zibaitis, M.D.42.36241700000000-71.0689370000000020596Zibaitis, AudriusInstructor in AnaesthesiaENB1EmeryBrownEmery Neal Brown, M.D., Ph.D.42.36241700000000-71.0689370000000056965Brown, EmeryWarren M. Zapol Professor of AnaesthesiaHF59Hua-JunFengHua-Jun Feng, M.D., Ph.D.102274Feng, Hua-JunAssistant Professor of AnaesthesiaJBC2JonathanCohenJonathan B. Cohen, Ph.D.42.33594500000000-71.1029580000000014275Cohen, JonathanBullard Professor of Neurobiology, EmeritusGJB3GaryBrennerGary Jay Brenner, M.D.,Ph.D.42.36241700000000-71.0689370000000082819Brenner, GaryAssociate Professor of AnaesthesiaPrincipal InvestigatorAuthorship 1195529731567362Yang X, Jounaidi Y, Mukherjee K, Fantasia RJ, Liao EC, Yu B, Forman SAAnesthesiologyDrug-selective Anesthetic Insensitivity of Zebrafish Lacking ?-Aminobutyric Acid Type A Receptor ß3 Subunits. Anesthesiology. 2019 12; 131(6):1276-1291.Anesthesiology2019-12-01T00:00:002019Drug-selective Anesthetic Insensitivity of Zebrafish Lacking ?-Aminobutyric Acid Type A Receptor ß3 Subunits.Authorship 1590921true1Instructor in AnaesthesiaInstructor in Anaesthesiatrue1Instructor in AnaesthesiaInstructor in Anaesthesiatrue1Warren M. Zapol Professor of AnaesthesiaWarren M. Zapol Professor of Anaesthesiatrue1Instructor in AnaesthesiaInstructor in Anaesthesiatrue1Lecturer on Anaesthesia, Part-timeLecturer on Anaesthesia, Part-timetrue1Associate Professor of AnaesthesiaAssociate Professor of Anaesthesiatrue1Assistant Professor of Anaesthesia, Part-timeAssistant Professor of Anaesthesia, Part-timetrue1Professor of AnaesthesiaProfessor of Anaesthesiatrue1Mallinckrodt Professor of Pharmacology in the Department of AnaesthesiaMallinckrodt Professor of Pharmacology in the Department of Anaesthesiatrue1Associate Professor of AnaesthesiaAssociate Professor of Anaesthesiatrue1Assistant Professor of AnaesthesiaAssistant Professor of Anaesthesiatrue1Henry Knowles Beecher Professor of AnaesthesiaHenry Knowles Beecher Professor of Anaesthesiatrue1Edward Mallinckrodt, Jr. Professor of Anaesthesia in the Field Pharmacology and InnovationEdward Mallinckrodt, Jr. Professor of Anaesthesia in the Field Pharmacology and InnovationAuthorship 1325701Authorship 1237886932247113Shalabi AR, Yu Z, Zhou X, Jounaidi Y, Chen H, Dai J, Kent DE, Feng HJ, Forman SA, Cohen JB, Bruzik KS, Miller KWEuropean journal of medicinal chemistryA potent photoreactive general anesthetic with novel binding site selectivity for GABAA receptors. Eur J Med Chem. 2020 May 15; 194:112261.Eur J Med Chem2020-03-23T00:00:002020A potent photoreactive general anesthetic with novel binding site selectivity for GABAA receptors.Authorship 1254224632541553McGrath M, Hoyt H, Pence A, Jayakar SS, Zhou X, Forman SA, Cohen JB, Miller KW, Raines DEAnesthesiologyCompetitive Antagonism of Etomidate Action by Diazepam: In Vitro GABAA Receptor and In Vivo Zebrafish Studies. Anesthesiology. 2020 09; 133(3):583-594.Anesthesiology2020-09-01T00:00:002020Competitive Antagonism of Etomidate Action by Diazepam: In Vitro GABAA Receptor and In Vivo Zebrafish Studies.Authorship 1288255132936873Forman SAAnesthesiologyNew Evidence of Receptor-based Pharmacology Underlying a Volatile Anesthetic Effect. Anesthesiology. 2020 11 01; 133(5):973-975.Anesthesiology2020-11-01T00:00:002020New Evidence of Receptor-based Pharmacology Underlying a Volatile Anesthetic Effect.Authorship 1314705633370831McGrath M, Hoyt H, Pence A, Jayakar SS, Zhou X, Forman SA, Cohen JB, Miller KW, Raines DEAnesthesiologyCompetitive Antagonism of Etomidate Action by Diazepam. Anesthesiology. 2020 09 01; 133(3):583-594.Anesthesiology2020-09-01T00:00:002020Competitive Antagonism of Etomidate Action by Diazepam.Authorship 1341524433766924Fantasia RJ, Nourmahnad A, Halpin E, Forman SAMolecular pharmacologySubstituted Cysteine Modification and Protection with n-Alkyl- Methanethiosulfonate Reagents Yields a Precise Estimate of the Distance between Etomidate and a Residue in Activated GABA Type A Receptors. Mol Pharmacol. 2021 06; 99(6):426-434.Mol Pharmacol2021-03-25T00:00:002021Substituted Cysteine Modification and Protection with n-Alkyl- Methanethiosulfonate Reagents Yields a Precise Estimate of the Distance between Etomidate and a Residue in Activated GABA Type A Receptors.2026-04-30FORMAN, STUART A2021-05-01Basic and Translational Research on General AnestheticsR35GM141951Principal InvestigatorAuthorship 1384465434386973McGrath M, Hoyt H, Pence A, Forman SA, Raines DEBritish journal of pharmacologySelective actions of benzodiazepines at the transmembrane anaesthetic binding sites of the GABAA receptor: In vitro and in vivo studies. Br J Pharmacol. 2021 12; 178(24):4842-4858.Br J Pharmacol2021-09-26T00:00:002021Selective actions of benzodiazepines at the transmembrane anaesthetic binding sites of the GABAA receptor: In vitro and in vivo studies.Authorship 2113751Authorship 29233413Authorship 1444547135482970Forman SAAnesthesiology?-Aminobutyric Acid Type A Receptor Subtypes and Circuit Connections in Midazolam-induced Amnesia, Sedation, and Hypnosis. Anesthesiology. 2022 06 01; 136(6):880-882.Anesthesiology2022-06-01T00:00:002022?-Aminobutyric Acid Type A Receptor Subtypes and Circuit Connections in Midazolam-induced Amnesia, Sedation, and Hypnosis.Authorship 3487981Authorship 14933861Authorship 14997694Authorship 1484573536269983Forman SA, Johnson KBAnesthesia and analgesiaUtilizing Pharmacogenomic Data in Perioperative Medicine: Feasibility, Value, and Inevitability. Anesth Analg. 2022 11 01; 135(5):926-928.Anesth Analg2022-10-21T00:00:002022Utilizing Pharmacogenomic Data in Perioperative Medicine: Feasibility, Value, and Inevitability.36167415Pence A, Hoyt H, McGrath M, Forman SA, Raines DEThe Journal of pharmacology and experimental therapeuticsCompetitive Interactions Between Propofol and Diazepam: Studies in GABAA Receptors and Zebrafish. J Pharmacol Exp Ther. 2022 12; 383(3):238-245.J Pharmacol Exp Ther2022-09-27T00:00:002022Competitive Interactions Between Propofol and Diazepam: Studies in GABAA Receptors and Zebrafish.36018576Hoyt H, Fantasia RJ, Bhave K, Yang X, Forman SAAnesthesiologyPhotomotor Responses in Zebrafish and Electrophysiology Reveal Varying Interactions of Anesthetics Targeting Distinct Sites on ?-Aminobutyric Acid Type A Receptors. Anesthesiology. 2022 11 01; 137(5):568-585.Anesthesiology2022-11-01T00:00:002022Photomotor Responses in Zebrafish and Electrophysiology Reveal Varying Interactions of Anesthetics Targeting Distinct Sites on ?-Aminobutyric Acid Type A Receptors.Authorship 1884771Authorship 2012081Authorship 5053989true1Bullard Professor of Neurobiology, EmeritusBullard Professor of Neurobiology, EmeritusAuthorship 20724810Authorship 2590581Authorship 1581513237586749Bhave K, Forman SAMolecular pharmacologySubstituted Cysteine Modification and Protection with n-Alkyl-MTS Reagents Quantifies Steric Changes Induced by a Mutation in Anesthetic Binding Sites on GABA Type A Receptors. Mol Pharmacol. 2023 Dec; 104(6):266-274.Mol Pharmacol2023-08-16T00:00:002023Substituted Cysteine Modification and Protection with n-Alkyl-MTS Reagents Quantifies Steric Changes Induced by a Mutation in Anesthetic Binding Sites on GABA Type A Receptors.Authorship 5114062Authorship 588464Authorship 5759782Authorship 2475331Authorship 601718Authorship 6420553Authorship 6340844Authorship 667534420858967Vanderweyde T, Bednar MM, Forman SA, Wolozin BJournal of Alzheimer's disease : JADIatrogenic risk factors for Alzheimer's disease: surgery and anesthesia. J Alzheimers Dis. 2010; 22 Suppl 3:91-104.J Alzheimers Dis2010-01-01T00:00:002010Iatrogenic risk factors for Alzheimer's disease: surgery and anesthesia.7797778Zaret BL, Wackers FJ, Terrin ML, Forman SA, Williams DO, Knatterud GL, Braunwald EJournal of the American College of CardiologyValue of radionuclide rest and exercise left ventricular ejection fraction in assessing survival of patients after thrombolytic therapy for acute myocardial infarction: results of Thrombolysis in Myocardial Infarction (TIMI) phase II study. The TIMI Study Group. J Am Coll Cardiol. 1995 Jul; 26(1):73-9.J Am Coll Cardiol1995-07-01T00:00:001995Value of radionuclide rest and exercise left ventricular ejection fraction in assessing survival of patients after thrombolytic therapy for acute myocardial infarction: results of Thrombolysis in Myocardial Infarction (TIMI) phase II study. The TIMI Study Group.23525330Stewart DS, Hotta M, Desai R, Forman SAMolecular pharmacologyState-dependent etomidate occupancy of its allosteric agonist sites measured in a cysteine-substituted GABAA receptor. Mol Pharmacol. 2013 Jun; 83(6):1200-8.Mol Pharmacol2013-03-22T00:00:002013State-dependent etomidate occupancy of its allosteric agonist sites measured in a cysteine-substituted GABAA receptor.Authorship 794281Authorship 798122Authorship 580157Authorship 592123Authorship 1557621Authorship 681795724009076Stewart DS, Hotta M, Li GD, Desai R, Chiara DC, Olsen RW, Forman SAThe Journal of biological chemistryCysteine substitutions define etomidate binding and gating linkages in the a-M1 domain of ?-aminobutyric acid type A (GABAA) receptors. J Biol Chem. 2013 Oct 18; 288(42):30373-30386.J Biol Chem2013-09-05T00:00:002013Cysteine substitutions define etomidate binding and gating linkages in the a-M1 domain of ?-aminobutyric acid type A (GABAA) receptors.Authorship 1912156Authorship 691767124195888Forman SAAnesthesiologyIn reply. Anesthesiology. 2013 Oct; 119(4):996.Anesthesiology2013-10-01T00:00:002013In reply.Authorship 2232613Authorship 703568724288268Dostalova Z, Zhou X, Liu A, Zhang X, Zhang Y, Desai R, Forman SA, Miller KWProtein science : a publication of the Protein SocietyHuman a1ß3?2L gamma-aminobutyric acid type A receptors: High-level production and purification in a functional state. Protein Sci. 2014 Feb; 23(2):157-66.Protein Sci2013-12-16T00:00:002013Human a1ß3?2L gamma-aminobutyric acid type A receptors: High-level production and purification in a functional state.Authorship 3271013Authorship 3311262Authorship 721967524199598Feng HJ, Jounaidi Y, Haburcak M, Yang X, Forman SABritish journal of pharmacologyEtomidate produces similar allosteric modulation in a1ß3d and a1ß3?2L GABA(A) receptors. Br J Pharmacol. 2014 Feb; 171(3):789-98.Br J Pharmacol2014-02-01T00:00:002014Etomidate produces similar allosteric modulation in a1ß3d and a1ß3?2L GABA(A) receptors.Authorship 3389846Authorship 3529133Authorship 4218732Authorship 2845553Authorship 44642Authorship 605849Authorship 607519Authorship 766088525347186Stewart DS, Pierce DW, Hotta M, Stern AT, Forman SAPloS oneMutations at beta N265 in ?-aminobutyric acid type A receptors alter both binding affinity and efficacy of potent anesthetics. PLoS One. 2014; 9(10):e111470.PLoS One2014-10-27T00:00:002014Mutations at beta N265 in ?-aminobutyric acid type A receptors alter both binding affinity and efficacy of potent anesthetics.Authorship 770726125299744Forman SA, Miller KW, Talmor D, Hickey P, Strichartz G, Wiener-Kronish JAnesthesiologyResearch at the Harvard Anesthesia Departments. Anesthesiology. 2014 Dec; 121(6):1141-3.Anesthesiology2014-12-01T00:00:002014Research at the Harvard Anesthesia Departments.Authorship 5294671Authorship 602030Authorship 61073525771493Zeng C, Long X, Cotten JF, Forman SA, Solt K, Faingold CL, Feng HJEpilepsy & behavior : E&BFluoxetine prevents respiratory arrest without enhancing ventilation in DBA/1 mice. Epilepsy Behav. 2015 Apr; 45:1-7.Epilepsy Behav2015-03-13T00:00:002015Fluoxetine prevents respiratory arrest without enhancing ventilation in DBA/1 mice.Authorship 627477Authorship 4373393Authorship 1710653Authorship 2666631Authorship 583388Authorship 591416Authorship 592285Authorship 596237Authorship 598777Authorship 592385Authorship 23951511Authorship 611268YJ87YoussefJounaidiYoussef Jounaidi, Ph.D.137218Jounaidi, YoussefInstructor in AnaesthesiaAuthorship 578729Authorship 582763Authorship 3245713Authorship 605624Authorship 608647Authorship 620786Authorship 603370Authorship 610094Authorship 823103Authorship 2455948Authorship 2730501Authorship 3813363Authorship 3965262Authorship 2855211Authorship 5053363Authorship 5733401Authorship 3386973Authorship 4110631Authorship 4231171Authorship 4505075Authorship 336811Authorship 4746592Authorship 4676894Authorship 8053754Authorship 601713Authorship 616137Authorship 623905Authorship 625032Authorship 628453Authorship 801541Authorship 3931993Authorship 4215715Authorship 4926023Authorship 579807Authorship 585030Authorship 591871Authorship 8092281Authorship 812777325316107Forman SA, Chiara DC, Miller KWNeuropharmacologyAnesthetics target interfacial transmembrane sites in nicotinic acetylcholine receptors. Neuropharmacology. 2015 Sep; 96(Pt B):169-77.Neuropharmacology2014-10-12T00:00:002014Anesthetics target interfacial transmembrane sites in nicotinic acetylcholine receptors.26028470Liu K, Jounaidi Y, Forman SA, Feng HJNeuroscienceEtomidate uniquely modulates the desensitization of recombinant a1ß3d GABA(A) receptors. Neuroscience. 2015 Aug 06; 300:307-13.Neuroscience2015-05-29T00:00:002015Etomidate uniquely modulates the desensitization of recombinant a1ß3d GABA(A) receptors.Authorship 5527321Authorship 581099Authorship 618563Authorship 620719Authorship 848598726378885Desai R, Savechenkov PY, Zolkowska D, Ge RL, Rogawski MA, Bruzik KS, Forman SA, Raines DE, Miller KWThe Journal of physiologyContrasting actions of a convulsant barbiturate and its anticonvulsant enantiomer on the a1 ß3 ?2L GABAA receptor account for their in vivo effects. J Physiol. 2015 Nov 15; 593(22):4943-61.J Physiol2015-11-15T00:00:002015Contrasting actions of a convulsant barbiturate and its anticonvulsant enantiomer on the a1 ß3 ?2L GABAA receptor account for their in vivo effects.Authorship 853011226569173Stern AT, Forman SAAnesthesiologyA Cysteine Substitution Probes ß3H267 Interactions with Propofol and Other Potent Anesthetics in a1ß3?2L ?-Aminobutyric Acid Type A Receptors. Anesthesiology. 2016 Jan; 124(1):89-100.Anesthesiology2016-01-01T00:00:002016A Cysteine Substitution Probes ß3H267 Interactions with Propofol and Other Potent Anesthetics in a1ß3?2L ?-Aminobutyric Acid Type A Receptors.Authorship 5492661Authorship 582565Authorship 588279Authorship 591301Authorship 597250Authorship 603711Authorship 647512Authorship 602245Authorship 615498Authorship 3568442Authorship 878969227110714Ziemba AM, Forman SAPloS oneCorrection for Inhibition Leads to an Allosteric Co-Agonist Model for Pentobarbital Modulation and Activation of a1ß3?2L GABAA Receptors. PLoS One. 2016; 11(4):e0154031.PLoS One2016-04-25T00:00:002016Correction for Inhibition Leads to an Allosteric Co-Agonist Model for Pentobarbital Modulation and Activation of a1ß3?2L GABAA Receptors.Authorship 880816527198062Maldifassi MC, Baur R, Pierce D, Nourmahnad A, Forman SA, Sigel EScientific reportsNovel positive allosteric modulators of GABAA receptors with anesthetic activity. Sci Rep. 2016 05 20; 6:25943.Sci Rep2016-05-20T00:00:002016Novel positive allosteric modulators of GABAA receptors with anesthetic activity.Authorship 5419091Authorship 5562671Authorship 604448Authorship 7577012Assistant Professor1Associate Professor0Full Professor4Instructor3LecturerAuthorship 612414Authorship 584078Authorship 584814Authorship 601597Authorship 578010Authorship 609646Authorship 6715542001-02-28FORMAN, STUART A1996-03-01NICOTINIC RECEPTOR SITES FOR ALCOHOL ACTIONSK21AA0002062009-08-31FORMAN, STUART A2003-03-01Volatile Anesthesia and the GABAA Receptor Gamma SubunitR01GM0667242020-08-31MILLER, KEITH W1998-12-01General Anesthetic Sites on Ligand Gated Ion ChannelsP01GM0584482022-07-31FORMAN, STUART A2010-09-01General Anesthetic Sites in GABA-A Receptor Subunit Interfacial PocketsR01GM0897452024-06-30FORMAN, STUART A1978-07-01Research Training for AnesthetistsT32GM007592Principal InvestigatorPrincipal InvestigatorCo-Principal InvestigatorPrincipal InvestigatorAuthorship 614862Authorship 596215Authorship 622609Authorship 3396058Authorship 9239101Authorship 927587727167687Forman SA, Miller KWAnesthesia and analgesiaMapping General Anesthetic Sites in Heteromeric ?-Aminobutyric Acid Type A Receptors Reveals a Potential For Targeting Receptor Subtypes. Anesth Analg. 2016 11; 123(5):1263-1273.Anesth Analg2016-11-01T00:00:002016Mapping General Anesthetic Sites in Heteromeric ?-Aminobutyric Acid Type A Receptors Reveals a Potential For Targeting Receptor Subtypes.27753644Nourmahnad A, Stern AT, Hotta M, Stewart DS, Ziemba AM, Szabo A, Forman SAAnesthesiologyTryptophan and Cysteine Mutations in M1 Helices of a1ß3?2L ?-Aminobutyric Acid Type A Receptors Indicate Distinct Intersubunit Sites for Four Intravenous Anesthetics and One Orphan Site. Anesthesiology. 2016 12; 125(6):1144-1158.Anesthesiology2016-12-01T00:00:002016Tryptophan and Cysteine Mutations in M1 Helices of a1ß3?2L ?-Aminobutyric Acid Type A Receptors Indicate Distinct Intersubunit Sites for Four Intravenous Anesthetics and One Orphan Site.Authorship 4783244Authorship 486911Authorship 930737227845976Rathmell JP, Forman S, Wanderer JPAnesthesiologyUnderstanding Intravenous General Anesthetics. Anesthesiology. 2016 Dec; 125(6):A21.Anesthesiology2016-12-01T00:00:002016Understanding Intravenous General Anesthetics.Authorship 581090Authorship 607322Authorship 620389Authorship 2047973Authorship 579842Wesleyan University, Ct1980Departmental High honors in ChemistryWesleyan University, Ct1980Hawk prize for undergraduate researchFoundation for Anesthesia Education and Research1993 (FAER) Starter GrantWhite House Office of Science and Technology Policy20042003 Presidential Early Career Award for Scientists and Engineers (PECASE)Harvard Medical School1989James Tolbert Shipley prize for published researchBoston Medical Foundation/Charles King Trust 19961995Research Fellowship AwardNational Institute on Alcohol Abuse and Alcoholism20011996Scientist Development Award (K21)Wesleyan University, Ct1980American Chemical Society AwardWesleyan University, Ct1980Magna cum laudeWesleyan University, Ct1980Phi Beta KappaAssociation of University Anesthesiologists19981998Election to Association of University Anesthesiologists1706469Wood SC, Forman SA, Miller KWMolecular pharmacologyShort chain and long chain alkanols have different sites of action on nicotinic acetylcholine receptor channels from Torpedo. Mol Pharmacol. 1991 Mar; 39(3):332-8.Mol Pharmacol1991-03-01T00:00:001991Short chain and long chain alkanols have different sites of action on nicotinic acetylcholine receptor channels from Torpedo.15791108Rüsch D, Forman SAAnesthesiologyClassic benzodiazepines modulate the open-close equilibrium in alpha1beta2gamma2L gamma-aminobutyric acid type A receptors. Anesthesiology. 2005 Apr; 102(4):783-92.Anesthesiology2005-04-01T00:00:002005Classic benzodiazepines modulate the open-close equilibrium in alpha1beta2gamma2L gamma-aminobutyric acid type A receptors.16013686Mashour GA, Forman SA, Campagna JABest practice & research. Clinical anaesthesiologyMechanisms of general anesthesia: from molecules to mind. Best Pract Res Clin Anaesthesiol. 2005 Sep; 19(3):349-64.Best Pract Res Clin Anaesthesiol2005-09-01T00:00:002005Mechanisms of general anesthesia: from molecules to mind.9449646Bergwitz C, Klein P, Kohno H, Forman SA, Lee K, Rubin D, Jüppner HEndocrinologyIdentification, functional characterization, and developmental expression of two nonallelic parathyroid hormone (PTH)/PTH-related peptide receptor isoforms in Xenopus laevis (Daudin). Endocrinology. 1998 Feb; 139(2):723-32.Endocrinology1998-02-01T00:00:001998Identification, functional characterization, and developmental expression of two nonallelic parathyroid hormone (PTH)/PTH-related peptide receptor isoforms in Xenopus laevis (Daudin).Authorship 969204428199655Bergwitz C, Klein P, Kohno H, Forman SA, Lee K, Rubin D, Ju Ppner HEndocrinologyIdentification, Functional Characterization, and Developmental Expression of Two Nonallelic Parathyroid Hormone (PTH)/PTH-Related Peptide Receptor Isoforms in Xenopus laevis (Daudin). Endocrinology. 1998 Feb 01; 139(2):723-732.Endocrinology1998-02-01T00:00:001998Identification, Functional Characterization, and Developmental Expression of Two Nonallelic Parathyroid Hormone (PTH)/PTH-Related Peptide Receptor Isoforms in Xenopus laevis (Daudin).17620835Solt K, Forman SACurrent opinion in anaesthesiologyCorrelating the clinical actions and molecular mechanisms of general anesthetics. Curr Opin Anaesthesiol. 2007 Aug; 20(4):300-6.Curr Opin Anaesthesiol2007-08-01T00:00:002007Correlating the clinical actions and molecular mechanisms of general anesthetics.11101308Zhou QL, Zhou Q, Forman SABiochemistryThe n-alcohol site in the nicotinic receptor pore is a hydrophobic patch. Biochemistry. 2000 Dec 05; 39(48):14920-6.Biochemistry2000-12-05T00:00:002000The n-alcohol site in the nicotinic receptor pore is a hydrophobic patch.2719927Forman SA, Miller KWBiochemistryProcaine rapidly inactivates acetylcholine receptors from Torpedo and competes with agonist for inhibition sites. Biochemistry. 1989 Feb 21; 28(4):1678-85.Biochemistry1989-02-21T00:00:001989Procaine rapidly inactivates acetylcholine receptors from Torpedo and competes with agonist for inhibition sites.21213095Forman SA, Miller KWCanadian journal of anaesthesia = Journal canadien d'anesthesieAnesthetic sites and allosteric mechanisms of action on Cys-loop ligand-gated ion channels. Can J Anaesth. 2011 Feb; 58(2):191-205.Can J Anaesth2011-01-07T00:00:002011Anesthetic sites and allosteric mechanisms of action on Cys-loop ligand-gated ion channels.Ackerman JR, Forman SA, Katz L, Kohler BE, Wu CTJournal of Chemical PhysicsPhotochemical site conversion: octatetraene in n-octane. Journal of Chemical Physics. 1984; 81:3387-3392.1984-01-01T00:00:001984Photochemical site conversion: octatetraene in n-octaneForman SAMolecular and Basic Mechanisms of AnesthesiaLigand-gated ion channel pore domains and anesthetics. Molecular and Basic Mechanisms of Anesthesia. 2002; 125.2002-01-01T00:00:002002Ligand-gated ion channel pore domains and anestheticsZhong H, Forman SASociety for Neuroscience Abstracts Irreversible modulation of GABAA receptors by Azi-etomidate, a photoreactive general anesthetic. Society for Neuroscience Abstracts. 2004; A160.1.2004-01-01T00:00:002004Irreversible modulation of GABAA receptors by Azi-etomidate, a photoreactive general anesthetic12505935Raines DE, Claycomb RJ, Forman SAAnesthesia and analgesiaModulation of GABA(A) receptor function by nonhalogenated alkane anesthetics: the effects on agonist enhancement, direct activation, and inhibition. Anesth Analg. 2003 Jan; 96(1):112-8, table of contents.Anesth Analg2003-01-01T00:00:002003Modulation of GABA(A) receptor function by nonhalogenated alkane anesthetics: the effects on agonist enhancement, direct activation, and inhibition.Authorship 9816511028505538Savechenkov PY, Chiara DC, Desai R, Stern AT, Zhou X, Ziemba AM, Szabo AL, Zhang Y, Cohen JB, Forman SA, Miller KW, Bruzik KSEuropean journal of medicinal chemistrySynthesis and pharmacological evaluation of neurosteroid photoaffinity ligands. Eur J Med Chem. 2017 Aug 18; 136:334-347.Eur J Med Chem2017-04-21T00:00:002017Synthesis and pharmacological evaluation of neurosteroid photoaffinity ligands.18539595Desai R, Kronengold J, Mei J, Forman SA, Kaczmarek LKThe Journal of biological chemistryProtein kinase C modulates inactivation of Kv3.3 channels. J Biol Chem. 2008 Aug 08; 283(32):22283-94.J Biol Chem2008-06-06T00:00:002008Protein kinase C modulates inactivation of Kv3.3 channels.10545178Forman SABiochemistryA hydrophobic photolabel inhibits nicotinic acetylcholine receptors via open-channel block following a slow step. Biochemistry. 1999 Nov 02; 38(44):14559-64.Biochemistry1999-11-02T00:00:001999A hydrophobic photolabel inhibits nicotinic acetylcholine receptors via open-channel block following a slow step.11003201Forman SA, Zhou QAlcoholism, clinical and experimental researchNicotinic receptor pore mutations create a sensitive inhibitory site for ethanol. Alcohol Clin Exp Res. 2000 Sep; 24(9):1363-8.Alcohol Clin Exp Res2000-09-01T00:00:002000Nicotinic receptor pore mutations create a sensitive inhibitory site for ethanol.21263301Forman SAAnesthesiologyClinical and molecular pharmacology of etomidate. Anesthesiology. 2011 Mar; 114(3):695-707.Anesthesiology2011-03-01T00:00:002011Clinical and molecular pharmacology of etomidate.Miller KW, Firestone LL, Forman SAE. Rubin, ed. Alcohol and the CellGeneral anesthetic and specific effects of ethanol on acetylcholine receptors. E. Rubin, ed. Alcohol and the Cell. 1987; 492:71-87.1987-01-01T00:00:001987General anesthetic and specific effects of ethanol on acetylcholine receptors16931973Forman SAAnesthesiologyOf mice and nematodes. Anesthesiology. 2006 Sep; 105(3):442-4.Anesthesiology2006-09-01T00:00:002006Of mice and nematodes.18045909Solt K, Ruesch D, Forman SA, Davies PA, Raines DEThe Journal of neuroscience : the official journal of the Society for NeuroscienceDifferential effects of serotonin and dopamine on human 5-HT3A receptor kinetics: interpretation within an allosteric kinetic model. J Neurosci. 2007 Nov 28; 27(48):13151-60.J Neurosci2007-11-28T00:00:002007Differential effects of serotonin and dopamine on human 5-HT3A receptor kinetics: interpretation within an allosteric kinetic model.55 Fruit StMassachusetts General HospitalAnesthesia Critical Care & Pain Medicine, Jackson 455 Fruit StBoston02114MA10464016Husain SS, Forman SA, Kloczewiak MA, Addona GH, Olsen RW, Pratt MB, Cohen JB, Miller KWJournal of medicinal chemistrySynthesis and properties of 3-(2-hydroxyethyl)-3-n-pentyldiazirine, a photoactivable general anesthetic. J Med Chem. 1999 Aug 26; 42(17):3300-7.J Med Chem1999-08-26T00:00:001999Synthesis and properties of 3-(2-hydroxyethyl)-3-n-pentyldiazirine, a photoactivable general anesthetic.12646036Husain SS, Ziebell MR, Ruesch D, Hong F, Arevalo E, Kosterlitz JA, Olsen RW, Forman SA, Cohen JB, Miller KWJournal of medicinal chemistry2-(3-Methyl-3H-diaziren-3-yl)ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate: a derivative of the stereoselective general anesthetic etomidate for photolabeling ligand-gated ion channels. J Med Chem. 2003 Mar 27; 46(7):1257-65.J Med Chem2003-03-27T00:00:0020032-(3-Methyl-3H-diaziren-3-yl)ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate: a derivative of the stereoselective general anesthetic etomidate for photolabeling ligand-gated ion channels.2440361Miller KW, Firestone LL, Forman SAAnnals of the New York Academy of SciencesGeneral anesthetic and specific effects of ethanol on acetylcholine receptors. Ann N Y Acad Sci. 1987; 492:71-87.Ann N Y Acad Sci1987-01-01T00:00:001987General anesthetic and specific effects of ethanol on acetylcholine receptors.Ruesch D, Forman SAAnesthesiology Interpreting the Impact of GABAA Receptor Structural Modifications Using an Allosteric Co-Agonist Mechanism for Etomidate Actions. Anesthesiology. 2004.2004-10-01T00:00:002004Interpreting the Impact of GABAA Receptor Structural Modifications Using an Allosteric Co-Agonist Mechanism for Etomidate ActionsForman SAInhibition of cation channel function at the nicotinic acetylcholine receptor from Torpedo: agonist self-inhibition and anesthetic drugs [Dissertation]Inhibition of cation channel function at the nicotinic acetylcholine receptor from Torpedo: agonist self-inhibition and anesthetic drugs [Dissertation]. 1989.1989-01-01T00:00:001989Inhibition of cation channel function at the nicotinic acetylcholine receptor from Torpedo: agonist self-inhibition and anesthetic drugs [Dissertation]Forman SA Verkman AS Dix, JA, Solomon AK. Biophys. J. Phloretin binds to band 3, the anion transport protein of the red blood cell membrane. Biophys. J. 1981; 33:48a.1981-02-01T00:00:001981Phloretin binds to band 3, the anion transport protein of the red blood cell membrane22052498Forman SA, Stewart DMethods in molecular biology (Clifton, N.J.)Mutations in the GABAA receptor that mimic the allosteric ligand etomidate. Methods Mol Biol. 2012; 796:317-33.Methods Mol Biol2012-01-01T00:00:002012Mutations in the GABAA receptor that mimic the allosteric ligand etomidate.19741491Desai R, Ruesch D, Forman SAAnesthesiologyGamma-amino butyric acid type A receptor mutations at beta2N265 alter etomidate efficacy while preserving basal and agonist-dependent activity. Anesthesiology. 2009 Oct; 111(4):774-84.Anesthesiology2009-10-01T00:00:002009Gamma-amino butyric acid type A receptor mutations at beta2N265 alter etomidate efficacy while preserving basal and agonist-dependent activity.2692257Forman SA, Miller KWTrends in pharmacological sciencesMolecular sites of anesthetic action in postsynaptic nicotinic membranes. Trends Pharmacol Sci. 1989 Nov; 10(11):447-52.Trends Pharmacol Sci1989-11-01T00:00:001989Molecular sites of anesthetic action in postsynaptic nicotinic membranes.20704351Husain SS, Stewart D, Desai R, Hamouda AK, Li SG, Kelly E, Dostalova Z, Zhou X, Cotten JF, Raines DE, Olsen RW, Cohen JB, Forman SA, Miller KWJournal of medicinal chemistryp-Trifluoromethyldiazirinyl-etomidate: a potent photoreactive general anesthetic derivative of etomidate that is selective for ligand-gated cationic ion channels. J Med Chem. 2010 Sep 09; 53(17):6432-44.J Med Chem2010-09-09T00:00:002010p-Trifluoromethyldiazirinyl-etomidate: a potent photoreactive general anesthetic derivative of etomidate that is selective for ligand-gated cationic ion channels.Forman SA, Zhou Q.Alcoholism A pore mutation reveals that ethanol stabilizes the open nAChR receptor state. Alcoholism. 1998; 22:46A .1998-06-01T00:00:001998A pore mutation reveals that ethanol stabilizes the open nAChR receptor stateZhou Q, Forman SAAnesthesiology Hydrophobic scanning mutagenesis maps the hexanol site in the nicotinic receptor pore. Anesthesiology. 1998; 89:A702.1998-10-01T00:00:001998Hydrophobic scanning mutagenesis maps the hexanol site in the nicotinic receptor poreAuthorship 1010229428916655Jounaidi Y, Cotten JF, Miller KW, Forman SACancer researchTethering IL2 to Its Receptor IL2Rß Enhances Antitumor Activity and Expansion of Natural Killer NK92 Cells. Cancer Res. 2017 11 01; 77(21):5938-5951.Cancer Res2017-09-15T00:00:002017Tethering IL2 to Its Receptor IL2Rß Enhances Antitumor Activity and Expansion of Natural Killer NK92 Cells.22052979Ge RL, Pejo E, Haburcak M, Husain SS, Forman SA, Raines DEAnesthesia and analgesiaPharmacological studies of methoxycarbonyl etomidate's carboxylic acid metabolite. Anesth Analg. 2012 Aug; 115(2):305-8.Anesth Analg2011-11-03T00:00:002011Pharmacological studies of methoxycarbonyl etomidate's carboxylic acid metabolite.Zhong H, Forman SASociety for Neuroscience Abstracts Irreversible modulation of GABAA receptors by Azi-etomidate, a photoreactive general anesthetic. Society for Neuroscience Abstracts. 2004; A160.1.2004-11-01T00:00:002004Irreversible modulation of GABAA receptors by Azi-etomidate, a photoreactive general anestheticScheller M, Forman SAAnesthesiologyGeneral anesthetic effects on the ƒÑ-S270I mutation in a1b2g2L GABA-A receptors. Anesthesiology. 2000; v(3A):A-810.2000-10-01T00:00:002000General anesthetic effects on the ƒÑ-S270I mutation in a1b2g2L GABA-A receptorsForman SAPhotolysis of all-trans. octatetraene at 4 degrees Celsius [Honors Thesis]Photolysis of all-trans. octatetraene at 4 degrees Celsius [Honors Thesis]. 1980.1980-01-01T00:00:001980Photolysis of all-trans. octatetraene at 4 degrees Celsius [Honors Thesis]3416024Forman SA, Miller KWBiophysical journalHigh acetylcholine concentrations cause rapid inactivation before fast desensitization in nicotinic acetylcholine receptors from Torpedo. Biophys J. 1988 Jul; 54(1):149-58.Biophys J1988-07-01T00:00:001988High acetylcholine concentrations cause rapid inactivation before fast desensitization in nicotinic acetylcholine receptors from Torpedo.10049138Forman SAToxicology lettersDirect interactions of anesthetics and nonanesthetics with the nicotinic acetylcholine receptor pore. Toxicol Lett. 1998 Nov 23; 100-101:169-78.Toxicol Lett1998-11-23T00:00:001998Direct interactions of anesthetics and nonanesthetics with the nicotinic acetylcholine receptor pore.11506122Raines DE, Claycomb RJ, Scheller M, Forman SAAnesthesiologyNonhalogenated alkane anesthetics fail to potentiate agonist actions on two ligand-gated ion channels. Anesthesiology. 2001 Aug; 95(2):470-7.Anesthesiology2001-08-01T00:00:002001Nonhalogenated alkane anesthetics fail to potentiate agonist actions on two ligand-gated ion channels.12198040Raines DE, Claycomb RJ, Forman SAAnesthesia and analgesiaNonhalogenated anesthetic alkanes and perhalogenated nonimmobilizing alkanes inhibit alpha(4)beta(2) neuronal nicotinic acetylcholine receptors. Anesth Analg. 2002 Sep; 95(3):573-7, table of contents.Anesth Analg2002-09-01T00:00:002002Nonhalogenated anesthetic alkanes and perhalogenated nonimmobilizing alkanes inhibit alpha(4)beta(2) neuronal nicotinic acetylcholine receptors.12761368Campagna JA, Miller KW, Forman SAThe New England journal of medicineMechanisms of actions of inhaled anesthetics. N Engl J Med. 2003 May 22; 348(21):2110-24.N Engl J Med2003-05-22T00:00:002003Mechanisms of actions of inhaled anesthetics.Scheller M, Forman SAAnesthesiologyTwo GABA(A) receptor pore mutations differentially affect anesthetic sensitivity and gating kinetics. Anesthesiology. 2001.2001-10-01T00:00:002001Two GABA(A) receptor pore mutations differentially affect anesthetic sensitivity and gating kineticsMiller KW, Addona GH, Cohen JB, Forman SA, Husain SS, Kloczewiak MA, Olsen RWAnesthesiology Probing anesthetic sites of action with a novel general anesthetic; 3,3-azi-octan-1-ol. Anesthesiology. 1998; 89:A732.1998-10-01T00:00:001998Probing anesthetic sites of action with a novel general anesthetic; 3,3-azi-octan-1-olMiller KW, Braswell LM, Firestone LL, Dodson BA, Forman SAS.H. Roth, K.W. Miller, eds. Molecular and Cellular Mechanisms of AnestheticsGeneral anesthetics act both specifically and non-specifically on acetylcholine receptors. S.H. Roth, K.W. Miller, eds. Molecular and Cellular Mechanisms of Anesthetics. 1986; 125-137.1986-01-01T00:00:001986General anesthetics act both specifically and non-specifically on acetylcholine receptorsForman, S.A.Hypothermia: Mechanisms and Clinical Impact (Powerpoint Presentation and handout)Hypothermia: Mechanisms and Clinical Impact (Powerpoint Presentation and handout). 2002.2002-01-01T00:00:002002Hypothermia: Mechanisms and Clinical Impact (Powerpoint Presentation and handout)22104494Ruesch D, Neumann E, Wulf H, Forman SAAnesthesiologyAn allosteric coagonist model for propofol effects on a1ß2?2L ?-aminobutyric acid type A receptors. Anesthesiology. 2012 Jan; 116(1):47-55.Anesthesiology2012-01-01T00:00:002012An allosteric coagonist model for propofol effects on a1ß2?2L ?-aminobutyric acid type A receptors.8696332Forman SA, Yellen G, Thiele EANature geneticsAlternative mechanism for pathogenesis of an inherited epilepsy by a nicotinic AChR mutation. Nat Genet. 1996 Aug; 13(4):396-7.Nat Genet1996-08-01T00:00:001996Alternative mechanism for pathogenesis of an inherited epilepsy by a nicotinic AChR mutation.Authorship 1030037429192122Shin DJ, Germann AL, Johnson AD, Forman SA, Steinbach JH, Akk GMolecular pharmacologyPropofol Is an Allosteric Agonist with Multiple Binding Sites on Concatemeric Ternary GABAA Receptors. Mol Pharmacol. 2018 02; 93(2):178-189.Mol Pharmacol2017-11-30T00:00:002017Propofol Is an Allosteric Agonist with Multiple Binding Sites on Concatemeric Ternary GABAA Receptors.18805938Stewart D, Desai R, Cheng Q, Liu A, Forman SAMolecular pharmacologyTryptophan mutations at azi-etomidate photo-incorporation sites on alpha1 or beta2 subunits enhance GABAA receptor gating and reduce etomidate modulation. Mol Pharmacol. 2008 Dec; 74(6):1687-95.Mol Pharmacol2008-09-19T00:00:002008Tryptophan mutations at azi-etomidate photo-incorporation sites on alpha1 or beta2 subunits enhance GABAA receptor gating and reduce etomidate modulation.Stuart A. Forman and Huijun ZhongBasic and Systemic Mechanisms of Anesthesia Irreversible Modulation of GABA-A Receptors by Azi-etomidate, a Photo-reactive General Anesthetic. Basic and Systemic Mechanisms of Anesthesia. 2005; (ICS 5886).2005-08-01T00:00:002005Irreversible Modulation of GABA-A Receptors by Azi-etomidate, a Photo-reactive General AnestheticForman SA, Yellen G, Miller KW.Alcoholism A Site in the acetylcholine receptor’s channel modulates ethanol’s action. Alcoholism. 1995; 19:87A.1995-06-01T00:00:001995A Site in the acetylcholine receptor’s channel modulates ethanol’s action17910479Forman SA, Zhou QL, Stewart DSBiochemistryPhotoactivated 3-azioctanol irreversibly desensitizes muscle nicotinic ACh receptors via interactions at alphaE262. Biochemistry. 2007 Oct 23; 46(42):11911-8.Biochemistry2007-10-02T00:00:002007Photoactivated 3-azioctanol irreversibly desensitizes muscle nicotinic ACh receptors via interactions at alphaE262.18156888Zhong H, Rüsch D, Forman SAAnesthesiologyPhoto-activated azi-etomidate, a general anesthetic photolabel, irreversibly enhances gating and desensitization of gamma-aminobutyric acid type A receptors. Anesthesiology. 2008 Jan; 108(1):103-12.Anesthesiology2008-01-01T00:00:002008Photo-activated azi-etomidate, a general anesthetic photolabel, irreversibly enhances gating and desensitization of gamma-aminobutyric acid type A receptors.Authorship 1030842829210709Ziemba AM, Szabo A, Pierce DW, Haburcak M, Stern AT, Nourmahnad A, Halpin ES, Forman SAAnesthesiologyAlphaxalone Binds in Inner Transmembrane ß+-a- Interfaces of a1ß3?2 ?-Aminobutyric Acid Type A Receptors. Anesthesiology. 2018 02; 128(2):338-351.Anesthesiology2018-02-01T00:00:002018Alphaxalone Binds in Inner Transmembrane ß+-a- Interfaces of a1ß3?2 ?-Aminobutyric Acid Type A Receptors.Authorship 1036280229294355Feng HJ, Forman SAPharmacological researchComparison of aßd and aß? GABAA receptors: Allosteric modulation and identification of subunit arrangement by site-selective general anesthetics. Pharmacol Res. 2018 07; 133:289-300.Pharmacol Res2017-12-30T00:00:002017Comparison of aßd and aß? GABAA receptors: Allosteric modulation and identification of subunit arrangement by site-selective general anesthetics.Eckhardt WR, Forman SA, Denman W, Grillo HC, Muehrcke DAnesthesia & AnalgesiaAnother use for the Laryngeal Mask Airway- Tracheoplasty for Tracheopathica Osteoplastica. Anesthesia & Analgesia. 1995; 80:622-624.1995-01-01T00:00:001995Another use for the Laryngeal Mask Airway- Tracheoplasty for Tracheopathica OsteoplasticaRaines, DE, Forman SAMolecular Mechanisms of Anesthesia (electronic media chapter)Molecular Mechanisms of Anesthesia (electronic media chapter). 2001.2001-01-01T00:00:002001Molecular Mechanisms of Anesthesia (electronic media chapter)23364596Forman SAAnesthesiologyThe expanding genetic toolkit for exploring mechanisms of general anesthesia. Anesthesiology. 2013 Apr; 118(4):769-71.Anesthesiology2013-04-01T00:00:002013The expanding genetic toolkit for exploring mechanisms of general anesthesia.Raines DE, Claycomb R, Scheller M, Forman SA AnesthesiologyNonhalogenated alkane anesthetics act with specificity on ligand-gated ion channels. Anesthesiology. 2001.2001-10-01T00:00:002001Nonhalogenated alkane anesthetics act with specificity on ligand-gated ion channels9129819Forman SABiophysical journalHomologous mutations on different subunits cause unequal but additive effects on n-alcohol block in the nicotinic receptor pore. Biophys J. 1997 May; 72(5):2170-9.Biophys J1997-05-01T00:00:001997Homologous mutations on different subunits cause unequal but additive effects on n-alcohol block in the nicotinic receptor pore.11137757Scheller M, Forman SANeuroscience lettersButanol effects on gamma-amino butyric acid concentration-responses in human alpha1beta2gamma2L gamma-amino butyric acid type A receptors with a mutation at alpha1S270. Neurosci Lett. 2001 Jan 19; 297(3):179-82.Neurosci Lett2001-01-19T00:00:002001Butanol effects on gamma-amino butyric acid concentration-responses in human alpha1beta2gamma2L gamma-amino butyric acid type A receptors with a mutation at alpha1S270.1711816Miller KW, Wood SC, Forman SA, Bugge B, Hill WA, Abadji VAnnals of the New York Academy of SciencesThe nicotinic acetylcholine receptor in its membrane environment. Ann N Y Acad Sci. 1991; 625:600-15.Ann N Y Acad Sci1991-01-01T00:00:001991The nicotinic acetylcholine receptor in its membrane environment.Forman SA, Flood P, Raines DE Neural Mechanisms of Anesthesia--Antognini JF, Carstens E, Raines DE, eds.Nicotinic Channels and Anesthetics. Neural Mechanisms of Anesthesia--Antognini JF, Carstens E, Raines DE, eds. 2003; 283-297.2003-01-01T00:00:002003Nicotinic Channels and Anesthetics16884293Husain SS, Nirthanan S, Ruesch D, Solt K, Cheng Q, Li GD, Arevalo E, Olsen RW, Raines DE, Forman SA, Cohen JB, Miller KWJournal of medicinal chemistrySynthesis of trifluoromethylaryl diazirine and benzophenone derivatives of etomidate that are potent general anesthetics and effective photolabels for probing sites on ligand-gated ion channels. J Med Chem. 2006 Aug 10; 49(16):4818-25.J Med Chem2006-08-10T00:00:002006Synthesis of trifluoromethylaryl diazirine and benzophenone derivatives of etomidate that are potent general anesthetics and effective photolabels for probing sites on ligand-gated ion channels.9637648Forman SA, Raines DEAnesthesiologyNonanesthetic volatile drugs obey the Meyer-Overton correlation in two molecular protein site models. Anesthesiology. 1998 Jun; 88(6):1535-48.Anesthesiology1998-06-01T00:00:001998Nonanesthetic volatile drugs obey the Meyer-Overton correlation in two molecular protein site models.