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Thea Brennan-Krohn, M.D.

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Available: 11/30/22, Expires: 12/01/24

My lab performs research investigating novel treatment approaches for multidrug-resistant gram-negative bacteria including E. coli, Klebsiella, Burkholderia, Pseudomonas, and Acinetobacter. We are particularly focused on the identification of combinations of existing antibiotic and non-antibiotic drugs that prevent the emergence of resistance during treatment and on understanding how resistance to these drugs and drug combinations develops using genomic and transcriptomic approaches. A variety of projects in these areas are available for medical students, including antimicrobial susceptibility testing, time-kill assays, and sequencing and analysis of genomic data. Projects can be adapted to the student's areas of interest.


Research
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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01AI178875 (BRENNAN-KROHN, THEA) Aug 7, 2023 - Jul 31, 2028
    NIH
    Susceptibility and resistance of multidrug-resistant gram-negative bacteria to novel beta-lactam/beta-lactamase inhibitor combinations
    Role: Principal Investigator
  2. R21AI156039 (BRENNAN-KROHN, THEA) Mar 1, 2021 - Feb 29, 2024
    NIH
    Identification of potentiators of antimicrobial activity against multidrug-resistant Burkholderia cepacia complex infections in cystic fibrosis
    Role: Principal Investigator
  3. K08AI132716 (BRENNAN-KROHN, THEA) Feb 20, 2018 - Jan 31, 2024
    NIH
    Antimicrobial Synergy for Carbapenem-Resistant Enterobacteriaceae
    Role: Principal Investigator

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© 2024 President and Fellows of Harvard College
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.