PKB11PriscillaBrastianosPriscilla Kalliope Brastianos, M.D.59863Brastianos, PriscillaKalliopeDr. Brastianos is the Director of the Central Nervous System Metastasis Program at Massachusetts General Hospital. Her main research objectives are to investigate molecular drivers and to find new therapeutic targets for the treatment of brain metastases and other brain tumors. Her work in meningiomas, craniopharyngiomas and brain metastases has led to several multicenter clinical trials in humans. She also directs a multidisciplinary brain metastasis clinic at Massachusetts General Hospital.Associate Professor of Medicinecatalyst:eCommonsLogineCommons Loginprns:awardConferredByaward conferred byprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:address2address line 2vivo:address3address line 3vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipvivo:awardOrHonorawards and honorsAward or Honor ReceiptDepartmentDivisionvivo:hasResearchArearesearch areasvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:middleNamemiddle name or initialvivo:overviewoverviewvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titlerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonAuthorship 1061056129703764Brastianos PK, Ippen FM, Hafeez U, Gan HKThe oncologistEmerging Gene Fusion Drivers in Primary and Metastatic Central Nervous System Malignancies: A Review of Available Evidence for Systemic Targeted Therapies. Oncologist. 2018 09; 23(9):1063-1075.Oncologist2018-04-27T00:00:002018Emerging Gene Fusion Drivers in Primary and Metastatic Central Nervous System Malignancies: A Review of Available Evidence for Systemic Targeted Therapies.Authorship 1067774329798715Ippen FM, D'Andrea M, Brastianos PKPersonalized medicinePersonalized medicine in brain metastases: a plea for more translational studies. Per Med. 2018 05 01; 15(3):141-143.Per Med2018-05-01T00:00:002018Personalized medicine in brain metastases: a plea for more translational studies.22794289Brastianos PK, Batchelor TTHematology/oncology clinics of North AmericaPrimary central nervous system lymphoma: overview of current treatment strategies. Hematol Oncol Clin North Am. 2012 Aug; 26(4):897-916.Hematol Oncol Clin North Am2012-08-01T00:00:002012Primary central nervous system lymphoma: overview of current treatment strategies.Authorship 107111825Authorship 1070877129872694Alvarez-Breckenridge C, Miller JJ, Nayyar N, Gill CM, Kaneb A, D'Andrea M, Le LP, Lee J, Cheng J, Zheng Z, Butler WE, Multani P, Chow Maneval E, Ha Paek S, Toyota BD, Dias-Santagata D, Santagata S, Romero J, Shaw AT, Farago AF, Yip S, Cahill DP, Batchelor TT, Iafrate AJ, Brastianos PKNPJ precision oncologyClinical and radiographic response following targeting of BCAN-NTRK1 fusion in glioneuronal tumor. NPJ Precis Oncol. 2017; 1(1):5.NPJ Precis Oncol2017-03-20T00:00:002017Clinical and radiographic response following targeting of BCAN-NTRK1 fusion in glioneuronal tumor.29872714Brastianos PK, Nayyar N, Rosebrock D, Leshchiner I, Gill CM, Livitz D, Bertalan MS, D'Andrea M, Hoang K, Aquilanti E, Chukwueke UN, Kaneb A, Chi A, Plotkin S, Gerstner ER, Frosch MP, Suva ML, Cahill DP, Getz G, Batchelor TTNPJ precision oncologyResolving the phylogenetic origin of glioblastoma via multifocal genomic analysis of pre-treatment and treatment-resistant autopsy specimens. NPJ Precis Oncol. 2017; 1(1):33.NPJ Precis Oncol2017-09-18T00:00:002017Resolving the phylogenetic origin of glioblastoma via multifocal genomic analysis of pre-treatment and treatment-resistant autopsy specimens.23633565Ramkissoon LA, Horowitz PM, Craig JM, Ramkissoon SH, Rich BE, Schumacher SE, McKenna A, Lawrence MS, Bergthold G, Brastianos PK, Tabak B, Ducar MD, Van Hummelen P, MacConaill LE, Pouissant-Young T, Cho YJ, Taha H, Mahmoud M, Bowers DC, Margraf L, Tabori U, Hawkins C, Packer RJ, Hill DA, Pomeroy SL, Eberhart CG, Dunn IF, Goumnerova L, Getz G, Chan JA, Santagata S, Hahn WC, Stiles CD, Ligon AH, Kieran MW, Beroukhim R, Ligon KLProceedings of the National Academy of Sciences of the United States of AmericaGenomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1. Proc Natl Acad Sci U S A. 2013 May 14; 110(20):8188-93.Proc Natl Acad Sci U S A2013-04-30T00:00:002013Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1.Authorship 1080115330012875Sinicrope KD, Kaplan AB, Brastianos PKThe oncologistSeminoma with Neoplastic Meningitis Treated with Craniospinal Irradiation. Oncologist. 2018 11; 23(11):1385-1387.Oncologist2018-07-16T00:00:002018Seminoma with Neoplastic Meningitis Treated with Craniospinal Irradiation.Authorship 10870412230082399Shankar GM, Kirtane AR, Miller JJ, Mazdiyasni H, Rogner J, Tai T, Williams EA, Higuchi F, Juratli TA, Tateishi K, Koerner MVA, Tummala SS, Fink AL, Penson T, Schmidt SP, Wojtkiewicz GR, Baig A, Francis JM, Rinne ML, Batten JM, Batchelor TT, Brastianos PK, Curry WT, Barker FG, Jordan JT, Iafrate AJ, Chi AS, Lennerz JK, Meyerson M, Langer R, Wakimoto H, Traverso G, Cahill DPProceedings of the National Academy of Sciences of the United States of AmericaGenotype-targeted local therapy of glioma. Proc Natl Acad Sci U S A. 2018 09 04; 115(36):E8388-E8394.Proc Natl Acad Sci U S A2018-08-06T00:00:002018Genotype-targeted local therapy of glioma.30123936Juratli TA, McCabe D, Nayyar N, Williams EA, Silverman IM, Tummala SS, Fink AL, Baig A, Martinez-Lage M, Selig MK, Bihun IV, Shankar GM, Penson T, Lastrapes M, Daubner D, Meinhardt M, Hennig S, Kaplan AB, Fujio S, Kuter BM, Bertalan MS, Miller JJ, Batten JM, Ely HA, Christiansen J, Baretton GB, Stemmer-Rachamimov AO, Santagata S, Rivera MN, Barker FG, Schackert G, Wakimoto H, Iafrate AJ, Carter SL, Cahill DP, Brastianos PKActa neuropathologicaDMD genomic deletions characterize a subset of progressive/higher-grade meningiomas with poor outcome. Acta Neuropathol. 2018 11; 136(5):779-792.Acta Neuropathol2018-08-19T00:00:002018DMD genomic deletions characterize a subset of progressive/higher-grade meningiomas with poor outcome.Authorship 10889583620075834Brastianos PK, Batchelor TTClinical advances in hematology & oncology : H&OVEGF inhibitors in brain tumors. Clin Adv Hematol Oncol. 2009 Nov; 7(11):753-60, 768.Clin Adv Hematol Oncol2009-11-01T00:00:002009VEGF inhibitors in brain tumors.21523485Olson RA, Brastianos PK, Palma DAJournal of neuro-oncologyPrognostic and predictive value of epigenetic silencing of MGMT in patients with high grade gliomas: a systematic review and meta-analysis. J Neurooncol. 2011 Nov; 105(2):325-35.J Neurooncol2011-04-27T00:00:002011Prognostic and predictive value of epigenetic silencing of MGMT in patients with high grade gliomas: a systematic review and meta-analysis.15323466Zileli M, Hoscoskun C, Brastianos P, Sabah DNeurosurgical focusSurgical treatment of primary sacral tumors: complications associated with sacrectomy. Neurosurg Focus. 2003 Nov 15; 15(5):E9.Neurosurg Focus2003-11-15T00:00:002003Surgical treatment of primary sacral tumors: complications associated with sacrectomy.D008579Disorders35012020.514886MeningiomaD008577Disorders39812340.501546Meningeal NeoplasmsD058990Procedures123727270.426807Molecular Targeted TherapyD001932Disorders165687910.217595Brain NeoplasmsD003397Disorders1262810.781514CraniopharyngiomaMedicineNeurologyPathologyHematology/OncologyOncologyBrigham and Women's HospitalDana-Farber Cancer InstituteMassachusetts General Hospital1159selected publications2.186450.00545726260research areas2.61180.029350284coauthor of91.925110.986760similar toPYW1PatrickWenPatrick Yung Chih Wen, M.D.42.33789600000000-71.1072493000000022271Wen, PatrickProfessor of NeurologyDAR25DavidReardonDavid Allen Reardon, M.D.103403Reardon, DavidProfessor of MedicineERL7EdwardLawsEdward R. Laws, M.D.45569Laws, EdwardProfessor of Neurosurgery, EmeritusTTB1TracyBatchelorTracy Todd Batchelor, M.D.42.36241700000000-71.0689370000000023665Batchelor, TracyMartin A. Samuels Professor of NeurologySS156SandroSantagataSandro Santagata, M.D., Ph.D.42.33510370000000-71.1061649000000028545Santagata, SandroAssociate Professor of PathologyEAC4E.ChioccaE. Antonio Chiocca, M.D.,Ph.D.53734Chiocca, E.Harvey W. Cushing Professor of NeurosurgeryOA42OssamaAl-MeftyOssama Al-Mefty, M.D.103108Al-Mefty, OssamaLecturer on NeurosurgeryID30IbiayiDagogo-JackIbiayi Dagogo-Jack, M.D.100079Dagogo-Jack, IbiayiAssistant Professor of MedicineDPC5DanielCahillDaniel P. Cahill, M.D.,Ph.D.7100Cahill, DanielProfessor of Neurosurgerytrue1Instructor in NeurologyInstructor in Neurologytrue1Professor of NeurologyProfessor of Neurologytrue1Professor of MedicineProfessor of Medicinetrue1Lecturer on NeurosurgeryLecturer on NeurosurgeryAuthorship 1351161true1Associate Professor of MedicineAssociate Professor of Medicinetrue1Assistant Professor of MedicineAssistant Professor of MedicineAuthorship 1555592Authorship 1858591true1Professor of NeurosurgeryProfessor of NeurosurgeryAuthorship 3191521Authorship 509071true1Harvey W. Cushing Professor of NeurosurgeryHarvey W. Cushing Professor of Neurosurgerytrue1Martin A. Samuels Professor of NeurologyMartin A. Samuels Professor of Neurologytrue1Associate Professor of PathologyAssociate Professor of Pathologytrue1Professor of Neurosurgery, EmeritusProfessor of Neurosurgery, EmeritusAuthorship 503865124032107Walcott BP, Nahed BV, Brastianos PK, Loeffler JSFrontiers in oncologyRadiation Treatment for WHO Grade II and III Meningiomas. Front Oncol. 2013 Sep 02; 3:227.Front Oncol2013-09-02T00:00:002013Radiation Treatment for WHO Grade II and III Meningiomas.24029127Brastianos PK, Curry WT, Oh KSJournal of the National Comprehensive Cancer Network : JNCCNClinical discussion and review of the management of brain metastases. J Natl Compr Canc Netw. 2013 Sep 01; 11(9):1153-64.J Natl Compr Canc Netw2013-09-01T00:00:002013Clinical discussion and review of the management of brain metastases.Authorship 68654210Authorship 6902771NeurosurgeryAuthorship 717535124413733Brastianos PK, Taylor-Weiner A, Manley PE, Jones RT, Dias-Santagata D, Thorner AR, Lawrence MS, Rodriguez FJ, Bernardo LA, Schubert L, Sunkavalli A, Shillingford N, Calicchio ML, Lidov HG, Taha H, Martinez-Lage M, Santi M, Storm PB, Lee JY, Palmer JN, Adappa ND, Scott RM, Dunn IF, Laws ER, Stewart C, Ligon KL, Hoang MP, Van Hummelen P, Hahn WC, Louis DN, Resnick AC, Kieran MW, Getz G, Santagata SNature geneticsExome sequencing identifies BRAF mutations in papillary craniopharyngiomas. Nat Genet. 2014 Feb; 46(2):161-5.Nat Genet2014-01-12T00:00:002014Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas.Authorship 733813724675142Pier DB, Nunes FP, Plotkin SR, Stemmer-Rachamimov AO, Kim JC, Shih HA, Brastianos P, Lin AEEuropean journal of medical geneticsTurner syndrome and meningioma: support for a possible increased risk of neoplasia in Turner syndrome. Eur J Med Genet. 2014 May-Jun; 57(6):269-74.Eur J Med Genet2014-03-25T00:00:002014Turner syndrome and meningioma: support for a possible increased risk of neoplasia in Turner syndrome.Authorship 2750153Authorship 738356325086747Sevenich L, Bowman RL, Mason SD, Quail DF, Rapaport F, Elie BT, Brogi E, Brastianos PK, Hahn WC, Holsinger LJ, Massagué J, Leslie CS, Joyce JANature cell biologyAnalysis of tumour- and stroma-supplied proteolytic networks reveals a brain-metastasis-promoting role for cathepsin S. Nat Cell Biol. 2014 Sep; 16(9):876-88.Nat Cell Biol2014-08-03T00:00:002014Analysis of tumour- and stroma-supplied proteolytic networks reveals a brain-metastasis-promoting role for cathepsin S.25347344Abedalthagafi MS, Merrill PH, Bi WL, Jones RT, Listewnik ML, Ramkissoon SH, Thorner AR, Dunn IF, Beroukhim R, Alexander BM, Brastianos PK, Francis JM, Folkerth RD, Ligon KL, Van Hummelen P, Ligon AH, Santagata SOncotargetAngiomatous meningiomas have a distinct genetic profile with multiple chromosomal polysomies including polysomy of chromosome 5. Oncotarget. 2014 Nov 15; 5(21):10596-606.Oncotarget2014-11-15T00:00:002014Angiomatous meningiomas have a distinct genetic profile with multiple chromosomal polysomies including polysomy of chromosome 5.Authorship 7743911125492479Brastianos HC, Cahill DP, Brastianos PKCurrent neurology and neuroscience reportsSystemic therapy of brain metastases. Curr Neurol Neurosci Rep. 2015; 15(2):518.Curr Neurol Neurosci Rep2015-01-01T00:00:002015Systemic therapy of brain metastases.25589003Shankar GM, Taylor-Weiner A, Lelic N, Jones RT, Kim JC, Francis JM, Abedalthagafi M, Borges LF, Coumans JV, Curry WT, Nahed BV, Shin JH, Paek SH, Park SH, Stewart C, Lawrence MS, Cibulskis K, Thorner AR, Van Hummelen P, Stemmer-Rachamimov AO, Batchelor TT, Carter SL, Hoang MP, Santagata S, Louis DN, Barker FG, Meyerson M, Getz G, Brastianos PK, Cahill DPActa neuropathologica communicationsSporadic hemangioblastomas are characterized by cryptic VHL inactivation. Acta Neuropathol Commun. 2014 Dec 24; 2:167.Acta Neuropathol Commun2014-12-24T00:00:002014Sporadic hemangioblastomas are characterized by cryptic VHL inactivation.25609200Du Z, Abedalthagafi M, Aizer AA, McHenry AR, Sun HH, Bray MA, Viramontes O, Machaidze R, Brastianos PK, Reardon DA, Dunn IF, Freeman GJ, Ligon KL, Carpenter AE, Alexander BM, Agar NY, Rodig SJ, Bradshaw EM, Santagata SOncotargetIncreased expression of the immune modulatory molecule PD-L1 (CD274) in anaplastic meningioma. Oncotarget. 2015 Mar 10; 6(7):4704-16.Oncotarget2015-03-10T00:00:002015Increased expression of the immune modulatory molecule PD-L1 (CD274) in anaplastic meningioma.25844057Calligaris D, Feldman DR, Norton I, Brastianos PK, Dunn IF, Santagata S, Agar NYInternational journal of mass spectrometryMolecular typing of Meningiomas by Desorption Electrospray Ionization Mass Spectrometry Imaging for Surgical Decision-Making. Int J Mass Spectrom. 2015 Feb 01; 377:690-698.Int J Mass Spectrom2015-02-01T00:00:002015Molecular typing of Meningiomas by Desorption Electrospray Ionization Mass Spectrometry Imaging for Surgical Decision-Making.Authorship 4422671Authorship 3152201Authorship 460861Authorship 3377711Authorship 4344531Authorship 7898679Authorship 8030464Authorship 806787625526238Gainor JF, Sherman CA, Willoughby K, Logan J, Kennedy E, Brastianos PK, Chi AS, Shaw ATJournal of thoracic oncology : official publication of the International Association for the Study of Lung CancerAlectinib salvages CNS relapses in ALK-positive lung cancer patients previously treated with crizotinib and ceritinib. J Thorac Oncol. 2015 Feb; 10(2):232-6.J Thorac Oncol2015-02-01T00:00:002015Alectinib salvages CNS relapses in ALK-positive lung cancer patients previously treated with crizotinib and ceritinib.25727227Jones PS, Cahill DP, Brastianos PK, Flaherty KT, Curry WTNeurosurgical focusIpilimumab and craniotomy in patients with melanoma and brain metastases: a case series. Neurosurg Focus. 2015 Mar; 38(3):E5.Neurosurg Focus2015-03-01T00:00:002015Ipilimumab and craniotomy in patients with melanoma and brain metastases: a case series.25779946Eisele SC, Gill CM, Shankar GM, Brastianos PKClinical cancer research : an official journal of the American Association for Cancer ResearchPLEKHA5: A Key to Unlock the Blood-Brain Barrier? Clin Cancer Res. 2015 May 01; 21(9):1978-80.Clin Cancer Res2015-03-16T00:00:002015PLEKHA5: A Key to Unlock the Blood-Brain Barrier?25952489Brastianos PK, Cahill DPOncology (Williston Park, N.Y.)Management of brain metastases in the era of targeted and immunomodulatory therapies. Oncology (Williston Park). 2015 Apr; 29(4):261-3.Oncology (Williston Park)2015-04-01T00:00:002015Management of brain metastases in the era of targeted and immunomodulatory therapies.Authorship 808457426112808Neagu MR, Gill CM, Batchelor TT, Brastianos PKChinese clinical oncologyGenomic profiling of brain metastases: current knowledge and new frontiers. Chin Clin Oncol. 2015 Jun; 4(2):22.Chin Clin Oncol2015-06-01T00:00:002015Genomic profiling of brain metastases: current knowledge and new frontiers.Authorship 8237202226181761Shankar GM, Francis JM, Rinne ML, Ramkissoon SH, Huang FW, Venteicher AS, Akama-Garren EH, Kang YJ, Lelic N, Kim JC, Brown LE, Charbonneau SK, Golby AJ, Sekhar Pedamallu C, Hoang MP, Sullivan RJ, Cherniack AD, Garraway LA, Stemmer-Rachamimov A, Reardon DA, Wen PY, Brastianos PK, Curry WT, Barker FG, Hahn WC, Nahed BV, Ligon KL, Louis DN, Cahill DP, Meyerson MJAMA oncologyRapid Intraoperative Molecular Characterization of Glioma. JAMA Oncol. 2015 Aug; 1(5):662-7.JAMA Oncol2015-08-01T00:00:002015Rapid Intraoperative Molecular Characterization of Glioma.Authorship 8390201Authorship 8390211Authorship 8390224Authorship 8390233Authorship 83902429Authorship 8390253Authorship 8390267Authorship 839027820182015Damon Runyon Clinical Investigator AwardSociety for Neuro-Oncology2014Adult Translational Science AwardAmerican Association for Neuro-Oncology2014NextGen Star AwardAmerican Brain Tumor Association20142012Basic Science AwardASCO20132012Young Investigator AwardSusan G. Komen 20152012Postdoctoral Fellowship AwardTerri Brodeur Breast Cancer Foundation20142012Postdoctoral Fellowship20142012Brain Science Foundation Grant25287912Berghoff AS, Bartsch R, Wöhrer A, Streubel B, Birner P, Kros JM, Brastianos PK, von Deimling A, Preusser MActa neuropathologicaPredictive molecular markers in metastases to the central nervous system: recent advances and future avenues. Acta Neuropathol. 2014 Dec; 128(6):879-91.Acta Neuropathol2014-10-07T00:00:002014Predictive molecular markers in metastases to the central nervous system: recent advances and future avenues.26410082Brastianos PK, Carter SL, Santagata S, Cahill DP, Taylor-Weiner A, Jones RT, Van Allen EM, Lawrence MS, Horowitz PM, Cibulskis K, Ligon KL, Tabernero J, Seoane J, Martinez-Saez E, Curry WT, Dunn IF, Paek SH, Park SH, McKenna A, Chevalier A, Rosenberg M, Barker FG, Gill CM, Van Hummelen P, Thorner AR, Johnson BE, Hoang MP, Choueiri TK, Signoretti S, Sougnez C, Rabin MS, Lin NU, Winer EP, Stemmer-Rachamimov A, Meyerson M, Garraway L, Gabriel S, Lander ES, Beroukhim R, Batchelor TT, Baselga J, Louis DN, Getz G, Hahn WCCancer discoveryGenomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets. Cancer Discov. 2015 Nov; 5(11):1164-1177.Cancer Discov2015-09-26T00:00:002015Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets.26498373Brastianos PK, Shankar GM, Gill CM, Taylor-Weiner A, Nayyar N, Panka DJ, Sullivan RJ, Frederick DT, Abedalthagafi M, Jones PS, Dunn IF, Nahed BV, Romero JM, Louis DN, Getz G, Cahill DP, Santagata S, Curry WT, Barker FGJournal of the National Cancer InstituteDramatic Response of BRAF V600E Mutant Papillary Craniopharyngioma to Targeted Therapy. J Natl Cancer Inst. 2016 Feb; 108(2).J Natl Cancer Inst2015-10-23T00:00:002015Dramatic Response of BRAF V600E Mutant Papillary Craniopharyngioma to Targeted Therapy.Authorship 8427741UNC2UgonmaChukwuekeUgonma Nnenna Chukwueke, M.D.145076Chukwueke, UgonmaInstructor in Neurology26826201Abedalthagafi M, Bi WL, Aizer AA, Merrill PH, Brewster R, Agarwalla PK, Listewnik ML, Dias-Santagata D, Thorner AR, Van Hummelen P, Brastianos PK, Reardon DA, Wen PY, Al-Mefty O, Ramkissoon SH, Folkerth RD, Ligon KL, Ligon AH, Alexander BM, Dunn IF, Beroukhim R, Santagata SNeuro-oncologyOncogenic PI3K mutations are as common as AKT1 and SMO mutations in meningioma. Neuro Oncol. 2016 05; 18(5):649-55.Neuro Oncol2016-01-28T00:00:002016Oncogenic PI3K mutations are as common as AKT1 and SMO mutations in meningioma.Authorship 5622333Authorship 8622121Authorship 865435626563980Brastianos PK, Santagata SEuropean journal of endocrinologyENDOCRINE TUMORS: BRAF V600E mutations in papillary craniopharyngioma. Eur J Endocrinol. 2016 Apr; 174(4):R139-44.Eur J Endocrinol2015-11-12T00:00:002015ENDOCRINE TUMORS: BRAF V600E mutations in papillary craniopharyngioma.26845119Gainor JF, Chi AS, Logan J, Hu R, Oh KS, Brastianos PK, Shih HA, Shaw ATJournal of thoracic oncology : official publication of the International Association for the Study of Lung CancerAlectinib Dose Escalation Reinduces Central Nervous System Responses in Patients with Anaplastic Lymphoma Kinase-Positive Non-Small Cell Lung Cancer Relapsing on Standard Dose Alectinib. J Thorac Oncol. 2016 Feb; 11(2):256-60.J Thorac Oncol2015-12-18T00:00:002015Alectinib Dose Escalation Reinduces Central Nervous System Responses in Patients with Anaplastic Lymphoma Kinase-Positive Non-Small Cell Lung Cancer Relapsing on Standard Dose Alectinib.Authorship 88477711Authorship 886681327288470Chukwueke U, Batchelor T, Brastianos PJournal of oncology practiceManagement of Brain Metastases in Patients With Melanoma. J Oncol Pract. 2016 06; 12(6):536-42.J Oncol Pract2016-06-01T00:00:002016Management of Brain Metastases in Patients With Melanoma.2Assistant Professor1Associate Professor0Full Professor4Instructor3Lecturer27544060Lin JJ, Kennedy E, Sequist LV, Brastianos PK, Goodwin KE, Stevens S, Wanat AC, Stober LL, Digumarthy SR, Engelman JA, Shaw AT, Gainor JFJournal of thoracic oncology : official publication of the International Association for the Study of Lung CancerClinical Activity of Alectinib in Advanced RET-Rearranged Non-Small Cell Lung Cancer. J Thorac Oncol. 2016 11; 11(11):2027-2032.J Thorac Oncol2016-08-17T00:00:002016Clinical Activity of Alectinib in Advanced RET-Rearranged Non-Small Cell Lung Cancer.Authorship 908969926951380Nigim F, Esaki S, Hood M, Lelic N, James MF, Ramesh V, Stemmer-Rachamimov A, Cahill DP, Brastianos PK, Rabkin SD, Martuza RL, Wakimoto HNeuro-oncologyA new patient-derived orthotopic malignant meningioma model treated with oncolytic herpes simplex virus. Neuro Oncol. 2016 09; 18(9):1278-87.Neuro Oncol2016-03-06T00:00:002016A new patient-derived orthotopic malignant meningioma model treated with oncolytic herpes simplex virus.Authorship 9217404Authorship 9278871327707790Bi WL, Horowitz P, Greenwald NF, Abedalthagafi M, Agarwalla PK, Gibson WJ, Mei Y, Schumacher SE, Ben-David U, Chevalier A, Carter S, Tiao G, Brastianos PK, Ligon AH, Ducar M, MacConaill L, Laws ER, Santagata S, Beroukhim R, Dunn IFClinical cancer research : an official journal of the American Association for Cancer ResearchLandscape of Genomic Alterations in Pituitary Adenomas. Clin Cancer Res. 2017 Apr 01; 23(7):1841-1851.Clin Cancer Res2016-10-05T00:00:002016Landscape of Genomic Alterations in Pituitary Adenomas.27773784Dagogo-Jack I, Gill CM, Cahill DP, Santagata S, Brastianos PKPharmacology & therapeuticsTreatment of brain metastases in the modern genomic era. Pharmacol Ther. 2017 02; 170:64-72.Pharmacol Ther2016-10-20T00:00:002016Treatment of brain metastases in the modern genomic era.Authorship 942374328009966Castro BA, Kuang R, Brastianos PKDiscovery medicineNovel approaches in genetic characterization and targeted therapy for brain metastases. Discov Med. 2016 11; 22(122):237-250.Discov Med2016-11-01T00:00:002016Novel approaches in genetic characterization and targeted therapy for brain metastases.Authorship 9523525Authorship 9568232928170043Shankar GM, Abedalthagafi M, Vaubel RA, Merrill PH, Nayyar N, Gill CM, Brewster R, Bi WL, Agarwalla PK, Thorner AR, Reardon DA, Al-Mefty O, Wen PY, Alexander BM, van Hummelen P, Batchelor TT, Ligon KL, Ligon AH, Meyerson M, Dunn IF, Beroukhim R, Louis DN, Perry A, Carter SL, Giannini C, Curry WT, Cahill DP, Barker FG, Brastianos PK, Santagata SNeuro-oncologyGermline and somatic BAP1 mutations in high-grade rhabdoid meningiomas. Neuro Oncol. 2017 04 01; 19(4):535-545.Neuro Oncol2017-04-01T00:00:002017Germline and somatic BAP1 mutations in high-grade rhabdoid meningiomas.Authorship 971022228290769Chukwueke UN, Brastianos PKPharmacogenomicsSequencing brain metastases and opportunities for targeted therapies. Pharmacogenomics. 2017 Apr; 18(6):585-594.Pharmacogenomics2017-03-14T00:00:002017Sequencing brain metastases and opportunities for targeted therapies.28360267Venteicher AS, Tirosh I, Hebert C, Yizhak K, Neftel C, Filbin MG, Hovestadt V, Escalante LE, Shaw ML, Rodman C, Gillespie SM, Dionne D, Luo CC, Ravichandran H, Mylvaganam R, Mount C, Onozato ML, Nahed BV, Wakimoto H, Curry WT, Iafrate AJ, Rivera MN, Frosch MP, Golub TR, Brastianos PK, Getz G, Patel AP, Monje M, Cahill DP, Rozenblatt-Rosen O, Louis DN, Bernstein BE, Regev A, Suvà MLScience (New York, N.Y.)Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq. Science. 2017 03 31; 355(6332).Science2017-03-31T00:00:002017Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq.Authorship 97381925Authorship 977672228391317Alvarez-Breckenridge C, Brastianos PKNeuro-oncologySMO mutant olfactory groove meningiomas-the next in line for targeted therapy. Neuro Oncol. 2017 03 01; 19(3):305-306.Neuro Oncol2017-03-01T00:00:002017SMO mutant olfactory groove meningiomas-the next in line for targeted therapy.Authorship 978515228425754Lazaro T, Brastianos PKCNS oncologyImmunotherapy and targeted therapy in brain metastases: emerging options in precision medicine. CNS Oncol. 2017 04; 6(2):139-151.CNS Oncol2017-04-01T00:00:002017Immunotherapy and targeted therapy in brain metastases: emerging options in precision medicine.16094165Amundson E, Pradilla G, Brastianos P, Bagley C, Riley LH, Garonzik IM, McCarthy E, Wolinsky JP, Gokaslan ZLNeurosurgeryA novel intravertebral tumor model in rabbits. Neurosurgery. 2005 Aug; 57(2):341-6; discussion 341-6.Neurosurgery2005-08-01T00:00:002005A novel intravertebral tumor model in rabbits.20821351Brastianos PK, Batchelor TTTargeted oncologyVascular endothelial growth factor inhibitors in malignant gliomas. Target Oncol. 2010 Sep; 5(3):167-74.Target Oncol2010-09-07T00:00:002010Vascular endothelial growth factor inhibitors in malignant gliomas.19854325Brastianos PK, Yehia B, Fischer W, Moliterno A, Streiff MThe American journal of medicineWiped out. Am J Med. 2009 Nov; 122(11):1004-6.Am J Med2009-11-01T00:00:002009Wiped out.22473164Brastianos PJournal of clinical oncology : official journal of the American Society of Clinical OncologyKairos. J Clin Oncol. 2012 May 01; 30(13):1562.J Clin Oncol2012-04-02T00:00:002012Kairos.19742089Brastianos P, Gokaslan Z, McCarthy EFThe Iowa orthopaedic journalAneurysmal bone cysts of the sacrum: a report of ten cases and review of the literature. Iowa Orthop J. 2009; 29:74-8.Iowa Orthop J2009-01-01T00:00:002009Aneurysmal bone cysts of the sacrum: a report of ten cases and review of the literature.Authorship 10204923Authorship 1019798228993799Han CH, Brastianos PKFrontiers in oncologyGenetic Characterization of Brain Metastases in the Era of Targeted Therapy. Front Oncol. 2017; 7:230.Front Oncol2017-09-25T00:00:002017Genetic Characterization of Brain Metastases in the Era of Targeted Therapy.28741536Dagogo-Jack I, Carter SL, Brastianos PKTrends in cancerBrain Metastasis: Clinical Implications of Branched Evolution. Trends Cancer. 2016 07; 2(7):332-337.Trends Cancer2016-06-29T00:00:002016Brain Metastasis: Clinical Implications of Branched Evolution.16790385Brastianos PK, Swanson JW, Torbenson M, Sperati J, Karakousis PCThe Lancet. Infectious diseasesTuberculosis-associated haemophagocytic syndrome. Lancet Infect Dis. 2006 Jul; 6(7):447-54.Lancet Infect Dis2006-07-01T00:00:002006Tuberculosis-associated haemophagocytic syndrome.21789699Brastianos PK, Brastianos HC, Hsu W, Sciubba DM, Kosztowski T, Tyler BM, Recinos VR, Burger P, Grossman SAJournal of neuro-oncologyThe toxicity of intrathecal bevacizumab in a rabbit model of leptomeningeal carcinomatosis. J Neurooncol. 2012 Jan; 106(1):81-8.J Neurooncol2011-07-26T00:00:002011The toxicity of intrathecal bevacizumab in a rabbit model of leptomeningeal carcinomatosis.Authorship 1027976329165794Wang N, Bertalan MS, Brastianos PKCancerLeptomeningeal metastasis from systemic cancer: Review and update on management. Cancer. 2018 Jan 01; 124(1):21-35.Cancer2017-11-22T00:00:002017Leptomeningeal metastasis from systemic cancer: Review and update on management.15918958Brastianos P, Pradilla G, McCarthy E, Gokaslan ZLNeurosurgerySolitary thoracic osteochondroma: case report and review of the literature. Neurosurgery. 2005 Jun; 56(6):E1379; discussion E1379.Neurosurgery2005-06-01T00:00:002005Solitary thoracic osteochondroma: case report and review of the literature.23334667Brastianos PK, Horowitz PM, Santagata S, Jones RT, McKenna A, Getz G, Ligon KL, Palescandolo E, Van Hummelen P, Ducar MD, Raza A, Sunkavalli A, Macconaill LE, Stemmer-Rachamimov AO, Louis DN, Hahn WC, Dunn IF, Beroukhim RNature geneticsGenomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations. Nat Genet. 2013 Mar; 45(3):285-9.Nat Genet2013-01-20T00:00:002013Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations.Authorship 10372733Authorship 10377032429311016Sun M, De Velasco G, Brastianos PK, Aizer AA, Martin A, Moreira R, Nguyen PL, Trinh QD, Choueiri TKEuropean urology focusThe Development of Brain Metastases in Patients with Renal Cell Carcinoma: Epidemiologic Trends, Survival, and Clinical Risk Factors Using a Population-based Cohort. Eur Urol Focus. 2019 05; 5(3):474-481.Eur Urol Focus2018-01-05T00:00:002018The Development of Brain Metastases in Patients with Renal Cell Carcinoma: Epidemiologic Trends, Survival, and Clinical Risk Factors Using a Population-based Cohort.29312603Juratli TA, Thiede C, Koerner MVA, Tummala SS, Daubner D, Shankar GM, Williams EA, Martinez-Lage M, Soucek S, Robel K, Penson T, Krause M, Appold S, Meinhardt M, Pinzer T, Miller JJ, Krex D, Ely HA, Silverman IM, Christiansen J, Schackert G, Wakimoto H, Kirsch M, Brastianos PK, Cahill DPOncotargetIntratumoral heterogeneity and TERT promoter mutations in progressive/higher-grade meningiomas. Oncotarget. 2017 Dec 12; 8(65):109228-109237.Oncotarget2017-11-24T00:00:002017Intratumoral heterogeneity and TERT promoter mutations in progressive/higher-grade meningiomas.55 Fruit StMassachusetts General HospitalHematology/Oncology55 Fruit StBoston02114MA