Harvard Catalyst Profiles

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Stephen John Haggarty, Ph.D.

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Mentoring
Available: 03/01/22, Expires: 08/31/24

Trainees will learn how to generate and characterize neurons and neural progenitor cells derived from patient-specific, induced pluripotent stem cells (iPSCs) using functional genomic tools, including high-content imaging, RNA-seq, and small molecule screening. Stem cell models already generated include Fragile X syndrome, Rett syndrome, Pitt-Hopkins syndrome, Bipolar disorder, Schizophrenia, and Frontotemporal dementia due to MAPT (Tau) and GRN (Progranulin) mutations. Additional opportunties related to the newly lanched Massachusetts General Hospital Center for the Neuroscience of Psychedelics entail probling mechansims of neuroplasticity using novel pharmacological probes and natural products derived from psychoactive plants and fungi.


Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01NS109540 (HAGGARTY, STEPHEN J;RAMESH, VIJAYA) Jun 15, 2019 - May 30, 2024
    NIH
    Tuberous Sclerosis Complex Patients iPSC-derived NPCs and NCCs as Human Model Systems to Identify Novel Targets
    Role: Co-Principal Investigator
  2. R21NS109755 (WHEELER, VANESSA C) Feb 15, 2019 - Jan 31, 2021
    NIH
    Modifiers of C9orf72 repeat dynamics
    Role: Co-Principal Investigator
  3. R01NS108115 (HAGGARTY, STEPHEN J;HERZ, JOACHIM J) Sep 30, 2018 - Jul 31, 2023
    NIH
    Validation of Modulators of PGRN as Novel Therapeutics for Frontotemporal Dementi
    Role: Co-Principal Investigator
  4. R01NS099250 (HOOKER, JACOB M.) Jul 1, 2017 - Apr 30, 2022
    NIH
    Epigenetic Radiotracers for PET Imaging: Isoform-SelectiveHDAC Probes
    Role: Co-Principal Investigator
  5. R01AT009144 (PERLIS, ROY H.) Sep 30, 2015 - Sep 29, 2021
    NIH
    Patient-Derived Cellular Models of Putative Antidepressants
    Role: Principal Investigator

Bibliographic
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.