LR29LeeRubinLee Rubin, Ph.D.12439Rubin, Lee617/384-5799Professor of Stem Cell and Regenerative Biologycatalyst:eCommonsLogineCommons Loginprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:address2address line 2vivo:address3address line 3vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:personInPositionpositionsvivo:phoneNumberphonePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofvivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonAuthorship 10506587Authorship 105066435Authorship 10504937Authorship 105133711Authorship 10505103Authorship 10508553Authorship 10521143Authorship 105169210Authorship 10524216Authorship 10530733Authorship 10527623Authorship 105282910Authorship 10530717Authorship 10509605Authorship 105087715Authorship 105183813Authorship 105308010Authorship 105169123Authorship 105209314Authorship 105211914Authorship 10523183Authorship 10526065Authorship 10531048Authorship 105178511Authorship 105206914Authorship 1053103425104390Naryshkin NA, Weetall M, Dakka A, Narasimhan J, Zhao X, Feng Z, Ling KK, Karp GM, Qi H, Woll MG, Chen G, Zhang N, Gabbeta V, Vazirani P, Bhattacharyya A, Furia B, Risher N, Sheedy J, Kong R, Ma J, Turpoff A, Lee CS, Zhang X, Moon YC, Trifillis P, Welch EM, Colacino JM, Babiak J, Almstead NG, Peltz SW, Eng LA, Chen KS, Mull JL, Lynes MS, Rubin LL, Fontoura P, Santarelli L, Haehnke D, McCarthy KD, Schmucki R, Ebeling M, Sivaramakrishnan M, Ko CP, Paushkin SV, Ratni H, Gerlach I, Ghosh A, Metzger FScience (New York, N.Y.)Motor neuron disease. SMN2 splicing modifiers improve motor function and longevity in mice with spinal muscular atrophy. Science. 2014 Aug 08; 345(6197):688-93.Science2014-08-08T00:00:002014Motor neuron disease. SMN2 splicing modifiers improve motor function and longevity in mice with spinal muscular atrophy.16776596Dellovade T, Romer JT, Curran T, Rubin LLAnnual review of neuroscienceThe hedgehog pathway and neurological disorders. Annu Rev Neurosci. 2006; 29:539-63.Annu Rev Neurosci2006-01-01T00:00:002006The hedgehog pathway and neurological disorders.19500978Brunton SA, Stibbard JH, Rubin LL, Guicherit OM, Kruse LI, Price S, di Lucrezia R, MacKinnon CH, Avery A, Park Y, Buxton D, Boyd EABioorganic & medicinal chemistry lettersPotent agonists of the Hedgehog signaling pathway. Bioorg Med Chem Lett. 2009 Aug 01; 19(15):4308-11.Bioorg Med Chem Lett2009-05-29T00:00:002009Potent agonists of the Hedgehog signaling pathway.16802299Deshpande DM, Kim YS, Martinez T, Carmen J, Dike S, Shats I, Rubin LL, Drummond J, Krishnan C, Hoke A, Maragakis N, Shefner J, Rothstein JD, Kerr DAAnnals of neurologyRecovery from paralysis in adult rats using embryonic stem cells. Ann Neurol. 2006 Jul; 60(1):32-44.Ann Neurol2006-07-01T00:00:002006Recovery from paralysis in adult rats using embryonic stem cells.16185261Paladini RD, Saleh J, Qian C, Xu GX, Rubin LLThe Journal of investigative dermatologyModulation of hair growth with small molecule agonists of the hedgehog signaling pathway. J Invest Dermatol. 2005 Oct; 125(4):638-46.J Invest Dermatol2005-10-01T00:00:002005Modulation of hair growth with small molecule agonists of the hedgehog signaling pathway.16554476Soundararajan P, Miles GB, Rubin LL, Brownstone RM, Rafuse VFThe Journal of neuroscience : the official journal of the Society for NeuroscienceMotoneurons derived from embryonic stem cells express transcription factors and develop phenotypes characteristic of medial motor column neurons. J Neurosci. 2006 Mar 22; 26(12):3256-68.J Neurosci2006-03-22T00:00:002006Motoneurons derived from embryonic stem cells express transcription factors and develop phenotypes characteristic of medial motor column neurons.15983402Schnapp E, Kragl M, Rubin L, Tanaka EMDevelopment (Cambridge, England)Hedgehog signaling controls dorsoventral patterning, blastema cell proliferation and cartilage induction during axolotl tail regeneration. Development. 2005 Jul; 132(14):3243-53.Development2005-07-01T00:00:002005Hedgehog signaling controls dorsoventral patterning, blastema cell proliferation and cartilage induction during axolotl tail regeneration.28877995Feinberg K, Kolaj A, Wu C, Grinshtein N, Krieger JR, Moran MF, Rubin LL, Miller FD, Kaplan DRThe Journal of cell biologyA neuroprotective agent that inactivates prodegenerative TrkA and preserves mitochondria. J Cell Biol. 2017 11 06; 216(11):3655-3675.J Cell Biol2017-09-06T00:00:002017A neuroprotective agent that inactivates prodegenerative TrkA and preserves mitochondria.14642274Gabay L, Lowell S, Rubin LL, Anderson DJNeuronDeregulation of dorsoventral patterning by FGF confers trilineage differentiation capacity on CNS stem cells in vitro. Neuron. 2003 Oct 30; 40(3):485-99.Neuron2003-10-30T00:00:002003Deregulation of dorsoventral patterning by FGF confers trilineage differentiation capacity on CNS stem cells in vitro.28017471d'Ydewalle C, Ramos DM, Pyles NJ, Ng SY, Gorz M, Pilato CM, Ling K, Kong L, Ward AJ, Rubin LL, Rigo F, Bennett CF, Sumner CJNeuronThe Antisense Transcript SMN-AS1 Regulates SMN Expression and Is a Novel Therapeutic Target for Spinal Muscular Atrophy. Neuron. 2017 Jan 04; 93(1):66-79.Neuron2016-12-22T00:00:002016The Antisense Transcript SMN-AS1 Regulates SMN Expression and Is a Novel Therapeutic Target for Spinal Muscular Atrophy.19716296Robarge KD, Brunton SA, Castanedo GM, Cui Y, Dina MS, Goldsmith R, Gould SE, Guichert O, Gunzner JL, Halladay J, Jia W, Khojasteh C, Koehler MF, Kotkow K, La H, Lalonde RL, Lau K, Lee L, Marshall D, Marsters JC, Murray LJ, Qian C, Rubin LL, Salphati L, Stanley MS, Stibbard JH, Sutherlin DP, Ubhayaker S, Wang S, Wong S, Xie MBioorganic & medicinal chemistry lettersGDC-0449-a potent inhibitor of the hedgehog pathway. Bioorg Med Chem Lett. 2009 Oct 01; 19(19):5576-81.Bioorg Med Chem Lett2009-08-15T00:00:002009GDC-0449-a potent inhibitor of the hedgehog pathway.18275133Brunton SA, Stibbard JH, Rubin LL, Kruse LI, Guicherit OM, Boyd EA, Price SJournal of medicinal chemistryPotent inhibitors of the hedgehog signaling pathway. J Med Chem. 2008 Mar 13; 51(5):1108-10.J Med Chem2008-02-15T00:00:002008Potent inhibitors of the hedgehog signaling pathway.21558397Tang T, Tang JY, Li D, Reich M, Callahan CA, Fu L, Yauch RL, Wang F, Kotkow K, Chang KS, Shpall E, Wu A, Rubin LL, Marsters JC, Epstein EH, Caro I, de Sauvage FJClinical cancer research : an official journal of the American Association for Cancer ResearchTargeting superficial or nodular Basal cell carcinoma with topically formulated small molecule inhibitor of smoothened. Clin Cancer Res. 2011 May 15; 17(10):3378-87.Clin Cancer Res2011-05-10T00:00:002011Targeting superficial or nodular Basal cell carcinoma with topically formulated small molecule inhibitor of smoothened.14960493Kessaris N, Jamen F, Rubin LL, Richardson WDDevelopment (Cambridge, England)Cooperation between sonic hedgehog and fibroblast growth factor/MAPK signalling pathways in neocortical precursors. Development. 2004 Mar; 131(6):1289-98.Development2004-02-11T00:00:002004Cooperation between sonic hedgehog and fibroblast growth factor/MAPK signalling pathways in neocortical precursors.15380514Romer JT, Kimura H, Magdaleno S, Sasai K, Fuller C, Baines H, Connelly M, Stewart CF, Gould S, Rubin LL, Curran TCancer cellSuppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice. Cancer Cell. 2004 Sep; 6(3):229-40.Cancer Cell2004-09-01T00:00:002004Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice.28548834Palomo V, Perez DI, Roca C, Anderson C, Rodríguez-Muela N, Perez C, Morales-Garcia JA, Reyes JA, Campillo NE, Perez-Castillo AM, Rubin LL, Timchenko L, Gil C, Martinez AJournal of medicinal chemistrySubtly Modulating Glycogen Synthase Kinase 3 ß: Allosteric Inhibitor Development and Their Potential for the Treatment of Chronic Diseases. J Med Chem. 2017 06 22; 60(12):4983-5001.J Med Chem2017-06-06T00:00:002017Subtly Modulating Glycogen Synthase Kinase 3 ß: Allosteric Inhibitor Development and Their Potential for the Treatment of Chronic Diseases.24857041Gould SE, Low JA, Marsters JC, Robarge K, Rubin LL, de Sauvage FJ, Sutherlin DP, Wong H, Yauch RLExpert opinion on drug discoveryDiscovery and preclinical development of vismodegib. Expert Opin Drug Discov. 2014 Aug; 9(8):969-84.Expert Opin Drug Discov2014-05-23T00:00:002014Discovery and preclinical development of vismodegib.18754008Yauch RL, Gould SE, Scales SJ, Tang T, Tian H, Ahn CP, Marshall D, Fu L, Januario T, Kallop D, Nannini-Pepe M, Kotkow K, Marsters JC, Rubin LL, de Sauvage FJNatureA paracrine requirement for hedgehog signalling in cancer. Nature. 2008 Sep 18; 455(7211):406-10.Nature2008-08-27T00:00:002008A paracrine requirement for hedgehog signalling in cancer.Authorship 105805416Authorship 10585099Authorship 1058548829656897Christiansen EM, Yang SJ, Ando DM, Javaherian A, Skibinski G, Lipnick S, Mount E, O'Neil A, Shah K, Lee AK, Goyal P, Fedus W, Poplin R, Esteva A, Berndl M, Rubin LL, Nelson P, Finkbeiner SCellIn Silico Labeling: Predicting Fluorescent Labels in Unlabeled Images. Cell. 2018 04 19; 173(3):792-803.e19.Cell2018-04-12T00:00:002018In Silico Labeling: Predicting Fluorescent Labels in Unlabeled Images.29656925Ordureau A, Paulo JA, Zhang W, Ahfeldt T, Zhang J, Cohn EF, Hou Z, Heo JM, Rubin LL, Sidhu SS, Gygi SP, Harper JWMolecular cellDynamics of PARKIN-Dependent Mitochondrial Ubiquitylation in Induced Neurons and Model Systems Revealed by Digital Snapshot Proteomics. Mol Cell. 2018 04 19; 70(2):211-227.e8.Mol Cell2018-04-12T00:00:002018Dynamics of PARKIN-Dependent Mitochondrial Ubiquitylation in Induced Neurons and Model Systems Revealed by Digital Snapshot Proteomics.29672276Rodriguez-Muela N, Parkhitko A, Grass T, Gibbs RM, Norabuena EM, Perrimon N, Singh R, Rubin LLThe Journal of clinical investigationBlocking p62-dependent SMN degradation ameliorates spinal muscular atrophy disease phenotypes. J Clin Invest. 2018 07 02; 128(7):3008-3023.J Clin Invest2018-06-11T00:00:002018Blocking p62-dependent SMN degradation ameliorates spinal muscular atrophy disease phenotypes.21649940Rubin LL, Haston KMBMC biologyStem cell biology and drug discovery. BMC Biol. 2011 Jun 07; 9:42.BMC Biol2011-06-07T00:00:002011Stem cell biology and drug discovery.Authorship 107490715Authorship 10730391329887317Gibbs RM, Lipnick S, Bateman JW, Chen L, Cousins HC, Hubbard EG, Jowett G, LaPointe DS, McGredy MJ, Odonkor MN, Repetti G, Thomas E, Rubin LLCell stem cellToward Precision Medicine for Neurological and Neuropsychiatric Disorders. Cell Stem Cell. 2018 07 05; 23(1):21-24.Cell Stem Cell2018-06-07T00:00:002018Toward Precision Medicine for Neurological and Neuropsychiatric Disorders.12588889Calcutt NA, Allendoerfer KL, Mizisin AP, Middlemas A, Freshwater JD, Burgers M, Ranciato R, Delcroix JD, Taylor FR, Shapiro R, Strauch K, Dudek H, Engber TM, Galdes A, Rubin LL, Tomlinson DRThe Journal of clinical investigationTherapeutic efficacy of sonic hedgehog protein in experimental diabetic neuropathy. J Clin Invest. 2003 Feb; 111(4):507-14.J Clin Invest2003-02-01T00:00:002003Therapeutic efficacy of sonic hedgehog protein in experimental diabetic neuropathy.Authorship 1077709929971247Shin HY, Pfaff KL, Davidow LS, Sun C, Uozumi T, Yanagawa F, Yamazaki Y, Kiyota Y, Rubin LLeNeuroUsing Automated Live Cell Imaging to Reveal Early Changes during Human Motor Neuron Degeneration. eNeuro. 2018 May-Jun; 5(3).eNeuro2018-06-29T00:00:002018Using Automated Live Cell Imaging to Reveal Early Changes during Human Motor Neuron Degeneration.22554036Wang Y, Arvanites AC, Davidow L, Blanchard J, Lam K, Yoo JW, Coy S, Rubin LL, McMahon APACS chemical biologySelective identification of hedgehog pathway antagonists by direct analysis of smoothened ciliary translocation. ACS Chem Biol. 2012 Jun 15; 7(6):1040-8.ACS Chem Biol2012-05-03T00:00:002012Selective identification of hedgehog pathway antagonists by direct analysis of smoothened ciliary translocation.21685895Makhortova NR, Hayhurst M, Cerqueira A, Sinor-Anderson AD, Zhao WN, Heiser PW, Arvanites AC, Davidow LS, Waldon ZO, Steen JA, Lam K, Ngo HD, Rubin LLNature chemical biologyA screen for regulators of survival of motor neuron protein levels. Nat Chem Biol. 2011 Jun 19; 7(8):544-52.Nat Chem Biol2011-06-19T00:00:002011A screen for regulators of survival of motor neuron protein levels.Authorship 1088285530120125Darnell M, O'Neil A, Mao A, Gu L, Rubin LL, Mooney DJProceedings of the National Academy of Sciences of the United States of AmericaMaterial microenvironmental properties couple to induce distinct transcriptional programs in mammalian stem cells. Proc Natl Acad Sci U S A. 2018 09 04; 115(36):E8368-E8377.Proc Natl Acad Sci U S A2018-08-17T00:00:002018Material microenvironmental properties couple to induce distinct transcriptional programs in mammalian stem cells.19287398Chen S, Borowiak M, Fox JL, Maehr R, Osafune K, Davidow L, Lam K, Peng LF, Schreiber SL, Rubin LL, Melton DNature chemical biologyA small molecule that directs differentiation of human ESCs into the pancreatic lineage. Nat Chem Biol. 2009 Apr; 5(4):258-65.Nat Chem Biol2009-03-15T00:00:002009A small molecule that directs differentiation of human ESCs into the pancreatic lineage.Authorship 1111366630401824Benkler C, O'Neil AL, Slepian S, Qian F, Weinreb PH, Rubin LLScientific reportsAggregated SOD1 causes selective death of cultured human motor neurons. Sci Rep. 2018 11 06; 8(1):16393.Sci Rep2018-11-06T00:00:002018Aggregated SOD1 causes selective death of cultured human motor neurons.Authorship 1113866430470794Ozek C, Krolewski RC, Buchanan SM, Rubin LLScientific reportsGrowth Differentiation Factor 11 treatment leads to neuronal and vascular improvements in the hippocampus of aged mice. Sci Rep. 2018 11 23; 8(1):17293.Sci Rep2018-11-23T00:00:002018Growth Differentiation Factor 11 treatment leads to neuronal and vascular improvements in the hippocampus of aged mice.20075256Rihel J, Prober DA, Arvanites A, Lam K, Zimmerman S, Jang S, Haggarty SJ, Kokel D, Rubin LL, Peterson RT, Schier AFScience (New York, N.Y.)Zebrafish behavioral profiling links drugs to biological targets and rest/wake regulation. Science. 2010 Jan 15; 327(5963):348-51.Science2010-01-15T00:00:002010Zebrafish behavioral profiling links drugs to biological targets and rest/wake regulation.Authorship 1129041330699345Wu C, Watts ME, Rubin LLCell reportsMAP4K4 Activation Mediates Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis. Cell Rep. 2019 01 29; 26(5):1143-1156.e5.Cell Rep2019-01-29T00:00:002019MAP4K4 Activation Mediates Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis.Authorship 11366141030870495Lipnick SL, Agniel DM, Aggarwal R, Makhortova NR, Finlayson SG, Brocato A, Palmer N, Darras BT, Kohane I, Rubin LLPloS oneSystemic nature of spinal muscular atrophy revealed by studying insurance claims. PLoS One. 2019; 14(3):e0213680.PLoS One2019-03-14T00:00:002019Systemic nature of spinal muscular atrophy revealed by studying insurance claims.D009134Disorders1052580.750193Muscular Atrophy, SpinalD055495Phenomena4688210.602311NeurogenesisD057026Anatomy70517020.43642Induced Pluripotent Stem CellsD055412Chemicals & Drugs48960.905803Growth Differentiation FactorsD009046Anatomy3948430.670486Motor NeuronsNeurologyOrthopedic SurgeryPediatricsStem Cell and Regenerative BiologyStem Cell and Regen BioGeneticsBoston Children's HospitalFaculty of Arts & SciencesHarvard Medical SchoolMassachusetts General HospitalOSI1OleIsacsonOle Isacson, Dr.Med.Sci, M.B.42.39465440000000-71.1956711000000016740Isacson, OleProfessor of Neurology11107selected publications2.946950.00297475552research areas1.035110.023368376coauthor of55.570412.888360similar toAJW14AmyWagersAmy J Wagers, Ph.D.42.33839600000000-71.108403000000001943Wagers, AmyForst Family Professor of Stem Cell and Regenerative BiologyCW11ChristopherWalshChristopher A. Walsh, M.D., Ph.D.42.33849900000000-71.104460000000009592Walsh, ChristopherBullard Professor of Pediatrics and NeurologyAuthorship 11560371231111916Pak E, MacKenzie EL, Zhao X, Pazyra-Murphy MF, Park PMC, Wu L, Shaw DL, Addleson EC, Cayer SS, Lopez BG, Agar NYR, Rubin LL, Qi J, Merk DJ, Segal RANeuro-oncologyA large-scale drug screen identifies selective inhibitors of class I HDACs as a potential therapeutic option for SHH medulloblastoma. Neuro Oncol. 2019 09 06; 21(9):1150-1163.Neuro Oncol2019-09-06T00:00:002019A large-scale drug screen identifies selective inhibitors of class I HDACs as a potential therapeutic option for SHH medulloblastoma.RTL2RichardLeeRichard T. Lee, M.D.42.36070000000000-71.1009000000000017340Lee, RichardProfessor of Stem Cell and Regenerative BiologyCW13CliffordWoolfClifford Woolf, M.B.,B.Ch., Ph.D.42.33743600000000-71.1054470000000068111Woolf, CliffordProfessor of NeurologyGQD1GeorgeDaleyGeorge Quentin Daley, M.D., Ph.D.42.33812600000000-71.1049210000000062Daley, GeorgeCaroline Shields Walker Professor of MedicineBTD1BasilDarrasBasil T. Darras, M.D.42.33743600000000-71.1054470000000028065Darras, BasilProfessor of NeurologyAuthorship 1161887531181098Idkowiak-Baldys J, Santhanam U, Buchanan SM, Pfaff KL, Rubin LL, Lyga JPloS oneGrowth differentiation factor 11 (GDF11) has pronounced effects on skin biology. PLoS One. 2019; 14(6):e0218035.PLoS One2019-06-10T00:00:002019Growth differentiation factor 11 (GDF11) has pronounced effects on skin biology.NRM11NinaMakhortovaNina R Makhortova, Ph.D.42.37733800000000-71.1144210000000033044Makhortova, NinaInstructor in NeurologyAuthorship 117055819Authorship 1169887331284814Yang SJ, Lipnick SL, Makhortova NR, Venugopalan S, Fan M, Armstrong Z, Schlaeger TM, Deng L, Chung WK, O'Callaghan L, Geraschenko A, Whye D, Berndl M, Hazard J, Williams B, Narayanaswamy A, Ando DM, Nelson P, Rubin LLSLAS discovery : advancing life sciences R & DApplying Deep Neural Network Analysis to High-Content Image-Based Assays. SLAS Discov. 2019 09; 24(8):829-841.SLAS Discov2019-07-08T00:00:002019Applying Deep Neural Network Analysis to High-Content Image-Based Assays.31320806Watts ME, Wu C, Rubin LLJournal of experimental neuroscienceSuppression of MAP4K4 Signaling Ameliorates Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis-Molecular Studies Toward New Therapeutics. J Exp Neurosci. 2019; 13:1179069519862798.J Exp Neurosci2019-07-10T00:00:002019Suppression of MAP4K4 Signaling Ameliorates Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis-Molecular Studies Toward New Therapeutics.Authorship 11933101831551601Ximerakis M, Lipnick SL, Innes BT, Simmons SK, Adiconis X, Dionne D, Mayweather BA, Nguyen L, Niziolek Z, Ozek C, Butty VL, Isserlin R, Buchanan SM, Levine SS, Regev A, Bader GD, Levin JZ, Rubin LLNature neuroscienceSingle-cell transcriptomic profiling of the aging mouse brain. Nat Neurosci. 2019 10; 22(10):1696-1708.Nat Neurosci2019-09-24T00:00:002019Single-cell transcriptomic profiling of the aging mouse brain.Authorship 11994561031644914Koutmani Y, Gampierakis IA, Polissidis A, Ximerakis M, Koutsoudaki PN, Polyzos A, Agrogiannis G, Karaliota S, Thomaidou D, Rubin LL, Politis PK, Karalis KPCell reportsCRH Promotes the Neurogenic Activity of Neural Stem Cells in the Adult Hippocampus. Cell Rep. 2019 10 22; 29(4):932-945.e7.Cell Rep2019-10-22T00:00:002019CRH Promotes the Neurogenic Activity of Neural Stem Cells in the Adult Hippocampus.true1Professor of NeurologyProfessor of NeurologyAuthorship 12160731431902706Ahfeldt T, Ordureau A, Bell C, Sarrafha L, Sun C, Piccinotti S, Grass T, Parfitt GM, Paulo JA, Yanagawa F, Uozumi T, Kiyota Y, Harper JW, Rubin LLStem cell reportsPathogenic Pathways in Early-Onset Autosomal Recessive Parkinson's Disease Discovered Using Isogenic Human Dopaminergic Neurons. Stem Cell Reports. 2020 01 14; 14(1):75-90.Stem Cell Reports2020-01-02T00:00:002020Pathogenic Pathways in Early-Onset Autosomal Recessive Parkinson's Disease Discovered Using Isogenic Human Dopaminergic Neurons.Authorship 1235068332206168Howell K, Gibbs RM, Rubin LLCerebrum : the Dana forum on brain scienceSpinal Muscular Atrophy: Huge Steps. Cerebrum. 2019 Mar-Apr; 2019.Cerebrum2019-03-01T00:00:002019Spinal Muscular Atrophy: Huge Steps.32413331Toyohara T, Roudnicky F, Florido MHC, Nakano T, Yu H, Katsuki S, Lee M, Meissner T, Friesen M, Davidow LS, Ptaszek L, Abe T, Rubin LL, Pereira AC, Aikawa M, Cowan CACell stem cellPatient hiPSCs Identify Vascular Smooth Muscle Arylacetamide Deacetylase as Protective against Atherosclerosis. Cell Stem Cell. 2020 07 02; 27(1):147-157.e7.Cell Stem Cell2020-05-14T00:00:002020Patient hiPSCs Identify Vascular Smooth Muscle Arylacetamide Deacetylase as Protective against Atherosclerosis.Authorship 124985713Authorship 12633721332619513Toyohara T, Roudnicky F, Florido MHC, Nakano T, Yu H, Katsuki S, Lee M, Meissner T, Friesen M, Davidow LS, Ptaszek L, Abe T, Rubin LL, Pereira AC, Aikawa M, Cowan CACell stem cellPatient hiPSCs Identify Vascular Smooth Muscle Arylacetamide Deacetylase as Protective against Atherosclerosis. Cell Stem Cell. 2020 Jul 02; 27(1):178-180.Cell Stem Cell2020-07-02T00:00:002020Patient hiPSCs Identify Vascular Smooth Muscle Arylacetamide Deacetylase as Protective against Atherosclerosis.32674174Malpani R, Mclynn RP, Bovonratwet P, Bagi PS, Yurter A, Mercier MR, Rubin LE, Grauer JNOrthopedicsCoagulopathies Are a Risk Factor for Adverse Events Following Total Hip and Total Knee Arthroplasty. Orthopedics. 2020 Jul 01; 43(4):233-238.Orthopedics2020-07-01T00:00:002020Coagulopathies Are a Risk Factor for Adverse Events Following Total Hip and Total Knee Arthroplasty.BCMPAuthorship 1283739932938453Walsh MB, Janzen E, Wingrove E, Hosseinibarkooie S, Muela NR, Davidow L, Dimitriadi M, Norabuena EM, Rubin LL, Wirth B, Hart ACBMC biologyGenetic modifiers ameliorate endocytic and neuromuscular defects in a model of spinal muscular atrophy. BMC Biol. 2020 09 16; 18(1):127.BMC Biol2020-09-16T00:00:002020Genetic modifiers ameliorate endocytic and neuromuscular defects in a model of spinal muscular atrophy.Authorship 12942231033036659Buchanan SM, Price FD, Castiglioni A, Gee AW, Schneider J, Matyas MN, Hayhurst M, Tabebordbar M, Wagers AJ, Rubin LLSkeletal musclePro-myogenic small molecules revealed by a chemical screen on primary muscle stem cells. Skelet Muscle. 2020 10 09; 10(1):28.Skelet Muscle2020-10-09T00:00:002020Pro-myogenic small molecules revealed by a chemical screen on primary muscle stem cells.Authorship 13117597Authorship 13241031033503437Almada AE, Horwitz N, Price FD, Gonzalez AE, Ko M, Bolukbasi OV, Messemer KA, Chen S, Sinha M, Rubin LL, Wagers AJCell reportsFOS licenses early events in stem cell activation driving skeletal muscle regeneration. Cell Rep. 2021 01 26; 34(4):108656.Cell Rep2021-01-26T00:00:002021FOS licenses early events in stem cell activation driving skeletal muscle regeneration.Authorship 13565891634006233Yuan W, Beaulieu-Jones B, Krolewski R, Palmer N, Veyrat-Follet C, Frau F, Cohen C, Bozzi S, Cogswell M, Kumar D, Coulouvrat C, Leroy B, Fischer TZ, Sardi SP, Chandross KJ, Rubin LL, Wills AM, Kohane I, Lipnick SLBMC neurologyAccelerating diagnosis of Parkinson's disease through risk prediction. BMC Neurol. 2021 May 18; 21(1):201.BMC Neurol2021-05-18T00:00:002021Accelerating diagnosis of Parkinson's disease through risk prediction.Authorship 13730155Authorship 1371023634168275Tomov ML, O'Neil A, Abbasi HS, Cimini BA, Carpenter AE, Rubin LL, Bathe MCommunications biologyResolving cell state in iPSC-derived human neural samples with multiplexed fluorescence imaging. Commun Biol. 2021 06 24; 4(1):786.Commun Biol2021-06-24T00:00:002021Resolving cell state in iPSC-derived human neural samples with multiplexed fluorescence imaging.34039214Kebaish KJ, Galivanche AR, Varthi AG, Ottesen TD, Rubin LE, Grauer JNOrthopedicsLong-term Corticosteroid Use Independently Correlates With Complications After Posterior Lumbar Spine Surgery. Orthopedics. 2021 May-Jun; 44(3):172-179.Orthopedics2021-05-01T00:00:002021Long-term Corticosteroid Use Independently Correlates With Complications After Posterior Lumbar Spine Surgery.tao915TaylorOttesenTaylor Ottesen, M.D.200266Ottesen, TaylorClinical Fellow in Orthopedic SurgeryAuthorship 1390565534473715Sadegh C, Ebina W, Arvanites AC, Davidow LS, Rubin LL, Macklis JDPloS oneSynthetic modified Fezf2 mRNA (modRNA) with concurrent small molecule SIRT1 inhibition enhances refinement of cortical subcerebral/corticospinal neuron identity from mouse embryonic stem cells. PLoS One. 2021; 16(9):e0254113.PLoS One2021-09-02T00:00:002021Synthetic modified Fezf2 mRNA (modRNA) with concurrent small molecule SIRT1 inhibition enhances refinement of cortical subcerebral/corticospinal neuron identity from mouse embryonic stem cells.Authorship 13918263Authorship 13947872434496254Cheng YC, Snavely A, Barrett LB, Zhang X, Herman C, Frost DJ, Riva P, Tochitsky I, Kawaguchi R, Singh B, Ivanis J, Huebner EA, Arvanites A, Oza V, Davidow L, Maeda R, Sakuma M, Grantham A, Wang Q, Chang AN, Pfaff K, Costigan M, Coppola G, Rubin LL, Schwer B, Alt FW, Woolf CJCell reportsTopoisomerase I inhibition and peripheral nerve injury induce DNA breaks and ATF3-associated axon regeneration in sensory neurons. Cell Rep. 2021 09 07; 36(10):109666.Cell Rep2021-09-07T00:00:002021Topoisomerase I inhibition and peripheral nerve injury induce DNA breaks and ATF3-associated axon regeneration in sensory neurons.34488822Mayweather BA, Buchanan SM, Rubin LLMolecular brainGDF11 expressed in the adult brain negatively regulates hippocampal neurogenesis. Mol Brain. 2021 09 06; 14(1):134.Mol Brain2021-09-06T00:00:002021GDF11 expressed in the adult brain negatively regulates hippocampal neurogenesis.34965416Martinez-Pastor B, Silveira GG, Clarke TL, Chung D, Gu Y, Cosentino C, Davidow LS, Mata G, Hassanieh S, Salsman J, Ciccia A, Bae N, Bedford MT, Megias D, Rubin LL, Efeyan A, Dellaire G, Mostoslavsky RCell reportsAssessing kinetics and recruitment of DNA repair factors using high content screens. Cell Rep. 2021 12 28; 37(13):110176.Cell Rep2021-12-28T00:00:002021Assessing kinetics and recruitment of DNA repair factors using high content screens.Authorship 14216483Authorship 14234261534967762Moore HG, Burroughs PJ, Rubin LE, Frumberg DB, Sculco PK, Grauer JNThe Journal of the American Academy of Orthopaedic SurgeonsPatients With Ehlers-Danlos Syndromes Experience Higher Rates of Prosthetic Dislocation After Total Hip Arthroplasty and Worse Implant Survival at 5 Years. J Am Acad Orthop Surg. 2022 Feb 15; 30(4):177-183.J Am Acad Orthop Surg2022-02-15T00:00:002022Patients With Ehlers-Danlos Syndromes Experience Higher Rates of Prosthetic Dislocation After Total Hip Arthroplasty and Worse Implant Survival at 5 Years.34972190Mercier MR, Galivanche AR, Brand JP, Pathak N, Medvecky MJ, Varthi AG, Rubin LE, Grauer JNPloS oneCOVID-positive ankle fracture patients are at increased odds of perioperative surgical complications following open reduction internal fixation surgery. PLoS One. 2021; 16(12):e0262115.PLoS One2021-12-31T00:00:002021COVID-positive ankle fracture patients are at increased odds of perioperative surgical complications following open reduction internal fixation surgery.Authorship 14269397Authorship 1468678335819835Gardezi M, Moore HG, Rubin LE, Grauer JNJournal of the American Academy of Orthopaedic Surgeons. Global research & reviewsPredictors of Physical Abuse in Elder Patients With Fracture. J Am Acad Orthop Surg Glob Res Rev. 2022 07 01; 6(7).J Am Acad Orthop Surg Glob Res Rev2022-07-01T00:00:002022Predictors of Physical Abuse in Elder Patients With Fracture.Authorship 147946817Authorship 1501022936044597Cronin SJF, Rao S, Tejada MA, Turnes BL, Licht-Mayer S, Omura T, Brenneis C, Jacobs E, Barrett L, Latremoliere A, Andrews N, Channon KM, Latini A, Arvanites AC, Davidow LS, Costigan M, Rubin LL, Penninger JM, Woolf CJScience translational medicinePhenotypic drug screen uncovers the metabolic GCH1/BH4 pathway as key regulator of EGFR/KRAS-mediated neuropathic pain and lung cancer. Sci Transl Med. 2022 08 31; 14(660):eabj1531.Sci Transl Med2022-08-31T00:00:002022Phenotypic drug screen uncovers the metabolic GCH1/BH4 pathway as key regulator of EGFR/KRAS-mediated neuropathic pain and lung cancer.36351019Spetz JKE, Florido MHC, Fraser CS, Qin X, Choiniere J, Yu SJ, Singh R, Friesen M, Rubin LL, Salem JE, Moslehi JJ, Sarosiek KAScience advancesHeightened apoptotic priming of vascular cells across tissues and life span predisposes them to cancer therapy-induced toxicities. Sci Adv. 2022 11 11; 8(45):eabn6579.Sci Adv2022-11-09T00:00:002022Heightened apoptotic priming of vascular cells across tissues and life span predisposes them to cancer therapy-induced toxicities.Authorship 15122762336563689Rapino F, Natoli T, Limone F, O'Connor E, Blank J, Tegtmeyer M, Chen W, Norabuena E, Narula J, Hazelbaker D, Angelini G, Barrett L, O'Neil A, Beattie UK, Thanos JM, de Rivera H, Sheridan SD, Perlis RH, McCarroll SA, Stevens B, Subramanian A, Nehme R, Rubin LLStem cell reportsSmall-molecule screen reveals pathways that regulate C4 secretion in stem cell-derived astrocytes. Stem Cell Reports. 2023 01 10; 18(1):237-253.Stem Cell Reports2022-12-22T00:00:002022Small-molecule screen reveals pathways that regulate C4 secretion in stem cell-derived astrocytes.Authorship 15308332136917977Neel DV, Basu H, Gunner G, Bergstresser MD, Giadone RM, Chung H, Miao R, Chou V, Brody E, Jiang X, Lee E, Watts ME, Marques C, Held A, Wainger B, Lagier-Tourenne C, Zhang YJ, Petrucelli L, Young-Pearse TL, Chen-Plotkin AS, Rubin LL, Lieberman J, Chiu IMNeuronGasdermin-E mediates mitochondrial damage in axons and neurodegeneration. Neuron. 2023 04 19; 111(8):1222-1240.e9.Neuron2023-03-13T00:00:002023Gasdermin-E mediates mitochondrial damage in axons and neurodegeneration.Authorship 156955017Authorship 15690054Authorship 156742020Authorship 155376211Authorship 157281617Authorship 15666391437353544Paul KC, Krolewski RC, Lucumi Moreno E, Blank J, Holton KM, Ahfeldt T, Furlong M, Yu Y, Cockburn M, Thompson LK, Kreymerman A, Ricci-Blair EM, Li YJ, Patel HB, Lee RT, Bronstein J, Rubin LL, Khurana V, Ritz BNature communicationsPublisher Correction: A pesticide and iPSC dopaminergic neuron screen identifies and classifies Parkinson-relevant pesticides. Nat Commun. 2023 Jun 23; 14(1):3747.Nat Commun2023-06-23T00:00:002023Publisher Correction: A pesticide and iPSC dopaminergic neuron screen identifies and classifies Parkinson-relevant pesticides.37188109Cronin SJF, Davidow LS, Arvanites AC, Rubin LL, Penninger JM, Woolf CJBio-protocolImplementation of a Drug Screening Platform to TargetGch1 Expression in Injured Mouse Dorsal Root Ganglion Neurons. Bio Protoc. 2023 May 05; 13(9):e4666.Bio Protoc2023-05-05T00:00:002023Implementation of a Drug Screening Platform to TargetGch1 Expression in Injured Mouse Dorsal Root Ganglion Neurons.37193692Paul KC, Krolewski RC, Lucumi Moreno E, Blank J, Holton KM, Ahfeldt T, Furlong M, Yu Y, Cockburn M, Thompson LK, Kreymerman A, Ricci-Blair EM, Li YJ, Patel HB, Lee RT, Bronstein J, Rubin LL, Khurana V, Ritz BNature communicationsA pesticide and iPSC dopaminergic neuron screen identifies and classifies Parkinson-relevant pesticides. Nat Commun. 2023 05 16; 14(1):2803.Nat Commun2023-05-16T00:00:002023A pesticide and iPSC dopaminergic neuron screen identifies and classifies Parkinson-relevant pesticides.37083703Berryer MH, Rizki G, Nathanson A, Klein JA, Trendafilova D, Susco SG, Lam D, Messana A, Holton KM, Karhohs KW, Cimini BA, Pfaff K, Carpenter AE, Rubin LL, Barrett LEeLifeHigh-content synaptic phenotyping in human cellular models reveals a role for BET proteins in synapse assembly. Elife. 2023 04 21; 12.Elife2023-04-21T00:00:002023High-content synaptic phenotyping in human cellular models reveals a role for BET proteins in synapse assembly.37118429Ximerakis M, Holton KM, Giadone RM, Ozek C, Saxena M, Santiago S, Adiconis X, Dionne D, Nguyen L, Shah KM, Goldstein JM, Gasperini C, Gampierakis IA, Lipnick SL, Simmons SK, Buchanan SM, Wagers AJ, Regev A, Levin JZ, Rubin LLNature agingHeterochronic parabiosis reprograms the mouse brain transcriptome by shifting aging signatures in multiple cell types. Nat Aging. 2023 03; 3(3):327-345.Nat Aging2023-03-09T00:00:002023Heterochronic parabiosis reprograms the mouse brain transcriptome by shifting aging signatures in multiple cell types.34625559Pediaditakis I, Kodella KR, Manatakis DV, Le CY, Hinojosa CD, Tien-Street W, Manolakos ES, Vekrellis K, Hamilton GA, Ewart L, Rubin LL, Karalis KNature communicationsModeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption. Nat Commun. 2021 10 08; 12(1):5907.Nat Commun2021-10-08T00:00:002021Modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption.Authorship 15911749Authorship 15925861337534135Berryer MH, Tegtmeyer M, Binan L, Valakh V, Nathanson A, Trendafilova D, Crouse E, Klein JA, Meyer D, Pietiläinen O, Rapino F, Farhi SL, Rubin LL, McCarroll SA, Nehme R, Barrett LEiScienceRobust induction of functional astrocytes using NGN2 expression in human pluripotent stem cells. iScience. 2023 Jul 21; 26(7):106995.iScience2023-05-30T00:00:002023Robust induction of functional astrocytes using NGN2 expression in human pluripotent stem cells.35982785Pediaditakis I, Kodella KR, Manatakis DV, Le CY, Barthakur S, Sorets A, Gravanis A, Ewart L, Rubin LL, Manolakos ES, Hinojosa CD, Karalis KiScienceA microengineered Brain-Chip to model neuroinflammation in humans. iScience. 2022 Aug 19; 25(8):104813.iScience2022-07-21T00:00:002022A microengineered Brain-Chip to model neuroinflammation in humans.true1Clinical Fellow in Orthopedic SurgeryClinical Fellow in Orthopedic SurgeryHarvard Stem Cell InstituteAuthorship 1621706638235060Driss LB, Lian J, Walker RG, Howard JA, Thompson TB, Rubin LL, Wagers AJ, Lee RTThe journal of cardiovascular agingGDF11 and aging biology - controversies resolved and pending. J Cardiovasc Aging. 2023 Oct; 3(4).J Cardiovasc Aging2023-10-20T00:00:002023GDF11 and aging biology - controversies resolved and pending.Authorship 1622931838252550Ottesen TD, Amick M, Kirwin DS, Mercier MR, Brand J, Frumberg DB, Grauer JN, Rubin LEJournal of the American Academy of Orthopaedic Surgeons. Global research & reviewsIncreasing Value in Subspecialty Training: A Comparison of Variation in Surgical Complications for Pediatric Versus Other Fellowship-trained American Board of Orthopaedic Surgery Candidates in the Treatment of Supracondylar Fractures. J Am Acad Orthop Surg Glob Res Rev. 2024 Jan 01; 8(1).J Am Acad Orthop Surg Glob Res Rev2024-01-01T00:00:002024Increasing Value in Subspecialty Training: A Comparison of Variation in Surgical Complications for Pediatric Versus Other Fellowship-trained American Board of Orthopaedic Surgery Candidates in the Treatment of Supracondylar Fractures.true1Professor of Stem Cell and Regenerative BiologyProfessor of Stem Cell and Regenerative Biologytrue1Forst Family Professor of Stem Cell and Regenerative BiologyForst Family Professor of Stem Cell and Regenerative Biology2Professor of Stem Cell and Regenerative BiologyProfessor of Stem Cell and Regenerative Biology3Director of the Therapeutic Screening Center for the Harvard Stem Cell InstituteDirector of the Therapeutic Screening Center for the Harvard Stem Cell Institutetrue1Professor of Stem Cell and Regenerative BiologyProfessor of Stem Cell and Regenerative BiologyAuthorship 1627171638314348Watts ME, Giadone RM, Ordureau A, Holton KM, Harper JW, Rubin LLFrontiers in cellular neuroscienceAnalyzing the ER stress response in ALS patient derived motor neurons identifies druggable neuroprotective targets. Front Cell Neurosci. 2023; 17:1327361.Front Cell Neurosci2024-01-19T00:00:002024Analyzing the ER stress response in ALS patient derived motor neurons identifies druggable neuroprotective targets.Authorship 16303951true1Caroline Shields Walker Professor of MedicineCaroline Shields Walker Professor of Medicinetrue1Instructor in NeurologyInstructor in Neurologytrue1Bullard Professor of Pediatrics and NeurologyBullard Professor of Pediatrics and Neurologytrue1Professor of NeurologyProfessor of Neurologytrue1Professor of NeurologyProfessor of NeurologyAuthorship 6401359Authorship 6390421Authorship 65169014Authorship 6525338Authorship 63512011Authorship 6371912Authorship 66284225Authorship 6367951Authorship 6436125Authorship 6502591Authorship 65104613Authorship 65508110Authorship 65401413Authorship 6429788Authorship 65233014Authorship 65868410Authorship 6659651112679522Williams JA, Guicherit OM, Zaharian BI, Xu Y, Chai L, Wichterle H, Kon C, Gatchalian C, Porter JA, Rubin LL, Wang FYProceedings of the National Academy of Sciences of the United States of AmericaIdentification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions. Proc Natl Acad Sci U S A. 2003 Apr 15; 100(8):4616-21.Proc Natl Acad Sci U S A2003-04-04T00:00:002003Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions.17139287Rubin LL, de Sauvage FJNature reviews. Drug discoveryTargeting the Hedgehog pathway in cancer. Nat Rev Drug Discov. 2006 Dec; 5(12):1026-33.Nat Rev Drug Discov2006-12-01T00:00:002006Targeting the Hedgehog pathway in cancer.12437772Frank-Kamenetsky M, Zhang XM, Bottega S, Guicherit O, Wichterle H, Dudek H, Bumcrot D, Wang FY, Jones S, Shulok J, Rubin LL, Porter JAJournal of biologySmall-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists. J Biol. 2002 Nov 06; 1(2):10.J Biol2002-11-06T00:00:002002Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists.23757500Sen A, Dimlich DN, Guruharsha KG, Kankel MW, Hori K, Yokokura T, Brachat S, Richardson D, Loureiro J, Sivasankaran R, Curtis D, Davidow LS, Rubin LL, Hart AC, Van Vactor D, Artavanis-Tsakonas SProceedings of the National Academy of Sciences of the United States of AmericaGenetic circuitry of Survival motor neuron, the gene underlying spinal muscular atrophy. Proc Natl Acad Sci U S A. 2013 Jun 25; 110(26):E2371-80.Proc Natl Acad Sci U S A2013-06-11T00:00:002013Genetic circuitry of Survival motor neuron, the gene underlying spinal muscular atrophy.18295572Rubin LLCellStem cells and drug discovery: the beginning of a new era? Cell. 2008 Feb 22; 132(4):549-52.Cell2008-02-22T00:00:002008Stem cells and drug discovery: the beginning of a new era?15189341Lin LF, Rubin LL, Xu MJournal of neurochemistryA non-peptidyl neurotrophic small molecule for midbrain dopaminergic neurons. J Neurochem. 2004 Jun; 89(6):1387-95.J Neurochem2004-06-01T00:00:002004A non-peptidyl neurotrophic small molecule for midbrain dopaminergic neurons.23602540Yang YM, Gupta SK, Kim KJ, Powers BE, Cerqueira A, Wainger BJ, Ngo HD, Rosowski KA, Schein PA, Ackeifi CA, Arvanites AC, Davidow LS, Woolf CJ, Rubin LLCell stem cellA small molecule screen in stem-cell-derived motor neurons identifies a kinase inhibitor as a candidate therapeutic for ALS. Cell Stem Cell. 2013 Jun 06; 12(6):713-26.Cell Stem Cell2013-04-18T00:00:002013A small molecule screen in stem-cell-derived motor neurons identifies a kinase inhibitor as a candidate therapeutic for ALS.Authorship 7267951024797482Katsimpardi L, Litterman NK, Schein PA, Miller CM, Loffredo FS, Wojtkiewicz GR, Chen JW, Lee RT, Wagers AJ, Rubin LLScience (New York, N.Y.)Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors. Science. 2014 May 09; 344(6184):630-4.Science2014-05-05T00:00:002014Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors.Authorship 7470971224952596Ichida JK, Tcw J, Williams LA, Carter AC, Shi Y, Moura MT, Ziller M, Singh S, Amabile G, Bock C, Umezawa A, Rubin LL, Bradner JE, Akutsu H, Meissner A, Eggan KNature chemical biologyNotch inhibition allows oncogene-independent generation of iPS cells. Nat Chem Biol. 2014 Aug; 10(8):632-639.Nat Chem Biol2014-06-22T00:00:002014Notch inhibition allows oncogene-independent generation of iPS cells.25147906Cherry JJ, Kobayashi DT, Lynes MM, Naryshkin NN, Tiziano FD, Zaworski PG, Rubin LL, Jarecki JAssay and drug development technologiesAssays for the identification and prioritization of drug candidates for spinal muscular atrophy. Assay Drug Dev Technol. 2014 Aug; 12(6):315-41.Assay Drug Dev Technol2014-08-01T00:00:002014Assays for the identification and prioritization of drug candidates for spinal muscular atrophy.Authorship 765369925233132Blum B, Roose AN, Barrandon O, Maehr R, Arvanites AC, Davidow LS, Davis JC, Peterson QP, Rubin LL, Melton DAeLifeReversal of ß cell de-differentiation by a small molecule inhibitor of the TGFß pathway. Elife. 2014 Sep 16; 3:e02809.Elife2014-09-16T00:00:002014Reversal of ß cell de-differentiation by a small molecule inhibitor of the TGFß pathway.25420066Wainger BJ, Buttermore ED, Oliveira JT, Mellin C, Lee S, Saber WA, Wang AJ, Ichida JK, Chiu IM, Barrett L, Huebner EA, Bilgin C, Tsujimoto N, Brenneis C, Kapur K, Rubin LL, Eggan K, Woolf CJNature neuroscienceModeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts. Nat Neurosci. 2015 Jan; 18(1):17-24.Nat Neurosci2014-11-24T00:00:002014Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts.25456120Woodard CM, Campos BA, Kuo SH, Nirenberg MJ, Nestor MW, Zimmer M, Mosharov EV, Sulzer D, Zhou H, Paull D, Clark L, Schadt EE, Sardi SP, Rubin L, Eggan K, Brock M, Lipnick S, Rao M, Chang S, Li A, Noggle SACell reportsiPSC-derived dopamine neurons reveal differences between monozygotic twins discordant for Parkinson's disease. Cell Rep. 2014 Nov 20; 9(4):1173-82.Cell Rep2014-11-06T00:00:002014iPSC-derived dopamine neurons reveal differences between monozygotic twins discordant for Parkinson's disease.25437882Schlaeger TM, Daheron L, Brickler TR, Entwisle S, Chan K, Cianci A, DeVine A, Ettenger A, Fitzgerald K, Godfrey M, Gupta D, McPherson J, Malwadkar P, Gupta M, Bell B, Doi A, Jung N, Li X, Lynes MS, Brookes E, Cherry AB, Demirbas D, Tsankov AM, Zon LI, Rubin LL, Feinberg AP, Meissner A, Cowan CA, Daley GQNature biotechnologyA comparison of non-integrating reprogramming methods. Nat Biotechnol. 2015 Jan; 33(1):58-63.Nat Biotechnol2014-12-01T00:00:002014A comparison of non-integrating reprogramming methods.Stem Cell26076036Xue R, Lynes MD, Dreyfuss JM, Shamsi F, Schulz TJ, Zhang H, Huang TL, Townsend KL, Li Y, Takahashi H, Weiner LS, White AP, Lynes MS, Rubin LL, Goodyear LJ, Cypess AM, Tseng YHNature medicineClonal analyses and gene profiling identify genetic biomarkers of the thermogenic potential of human brown and white preadipocytes. Nat Med. 2015 Jul; 21(7):760-8.Nat Med2015-06-15T00:00:002015Clonal analyses and gene profiling identify genetic biomarkers of the thermogenic potential of human brown and white preadipocytes.Authorship 82058225Authorship 82057316Authorship 849745726321202Ng SY, Soh BS, Rodriguez-Muela N, Hendrickson DG, Price F, Rinn JL, Rubin LLCell stem cellGenome-wide RNA-Seq of Human Motor Neurons Implicates Selective ER Stress Activation in Spinal Muscular Atrophy. Cell Stem Cell. 2015 Nov 05; 17(5):569-84.Cell Stem Cell2015-08-27T00:00:002015Genome-wide RNA-Seq of Human Motor Neurons Implicates Selective ER Stress Activation in Spinal Muscular Atrophy.Authorship 874388927034275Walker RG, Poggioli T, Katsimpardi L, Buchanan SM, Oh J, Wattrus S, Heidecker B, Fong YW, Rubin LL, Ganz P, Thompson TB, Wagers AJ, Lee RTCirculation researchBiochemistry and Biology of GDF11 and Myostatin: Similarities, Differences, and Questions for Future Investigation. Circ Res. 2016 Apr 01; 118(7):1125-41; discussion 1142.Circ Res2016-04-01T00:00:002016Biochemistry and Biology of GDF11 and Myostatin: Similarities, Differences, and Questions for Future Investigation.Authorship 8869091227304920Rigamonti A, Repetti GG, Sun C, Price FD, Reny DC, Rapino F, Weisinger K, Benkler C, Peterson QP, Davidow LS, Hansson EM, Rubin LLStem cell reportsLarge-Scale Production of Mature Neurons from Human Pluripotent Stem Cells in a Three-Dimensional Suspension Culture System. Stem Cell Reports. 2016 06 14; 6(6):993-1008.Stem Cell Reports2016-06-14T00:00:002016Large-Scale Production of Mature Neurons from Human Pluripotent Stem Cells in a Three-Dimensional Suspension Culture System.6Fellow or Post Doc0Full Professor4InstructorAuthorship 897132227502604Katsimpardi L, Rubin LLNeurogenesis (Austin, Tex.)Young systemic factors as a medicine for age-related neurodegenerative diseases. Neurogenesis (Austin). 2015; 2(1):e1004971.Neurogenesis (Austin)2015-02-03T00:00:002015Young systemic factors as a medicine for age-related neurodegenerative diseases.26610635Brennand KJ, Marchetto MC, Benvenisty N, Brüstle O, Ebert A, Izpisua Belmonte JC, Kaykas A, Lancaster MA, Livesey FJ, McConnell MJ, McKay RD, Morrow EM, Muotri AR, Panchision DM, Rubin LL, Sawa A, Soldner F, Song H, Studer L, Temple S, Vaccarino FM, Wu J, Vanderhaeghen P, Gage FH, Jaenisch RStem cell reportsCreating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders. Stem Cell Reports. 2015 Dec 08; 5(6):933-945.Stem Cell Reports2015-11-21T00:00:002015Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders.2013-09-30MELTON, DOUGLAS A2010-09-25Identification of Genes and Compounds That Control Beta Cell ReplicationRC4DK0907812016-07-31VAN VACTOR, DAVID L.2010-08-01Genetic Modeling for SMA Therapeutic PathwaysP01NS066888Co-Principal InvestigatorCo-Principal InvestigatorAuthorship 926407327060768Ahfeldt T, Litterman NK, Rubin LLBrain researchStudying human disease using human neurons. Brain Res. 2017 02 01; 1656:40-48.Brain Res2016-04-06T00:00:002016Studying human disease using human neurons.22348181Chen PC, Gaisina IN, El-Khodor BF, Ramboz S, Makhortova NR, Rubin LL, Kozikowski APACS chemical neuroscienceIdentification of a Maleimide-Based Glycogen Synthase Kinase-3 (GSK-3) Inhibitor, BIP-135, that Prolongs the Median Survival Time of ?7 SMA KO Mouse Model of Spinal Muscular Atrophy. ACS Chem Neurosci. 2012 Jan 18; 3(1):5-11.ACS Chem Neurosci2012-01-18T00:00:002012Identification of a Maleimide-Based Glycogen Synthase Kinase-3 (GSK-3) Inhibitor, BIP-135, that Prolongs the Median Survival Time of ?7 SMA KO Mouse Model of Spinal Muscular Atrophy.Authorship 9565601428178525Rodriguez-Muela N, Litterman NK, Norabuena EM, Mull JL, Galazo MJ, Sun C, Ng SY, Makhortova NR, White A, Lynes MM, Chung WK, Davidow LS, Macklis JD, Rubin LLCell reportsSingle-Cell Analysis of SMN Reveals Its Broader Role in Neuromuscular Disease. Cell Rep. 2017 02 07; 18(6):1484-1498.Cell Rep2017-02-07T00:00:002017Single-Cell Analysis of SMN Reveals Its Broader Role in Neuromuscular Disease.12971894Machold R, Hayashi S, Rutlin M, Muzumdar MD, Nery S, Corbin JG, Gritli-Linde A, Dellovade T, Porter JA, Rubin LL, Dudek H, McMahon AP, Fishell GNeuronSonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches. Neuron. 2003 Sep 11; 39(6):937-50.Neuron2003-09-11T00:00:002003Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches.14577080Rubin LE, Stein PB, DiScala C, Grottkau BEJournal of pediatric surgeryPediatric trauma caused by personal watercraft: a ten-year retrospective. J Pediatr Surg. 2003 Oct; 38(10):1525-9.J Pediatr Surg2003-10-01T00:00:002003Pediatric trauma caused by personal watercraft: a ten-year retrospective.19818703Ichida JK, Blanchard J, Lam K, Son EY, Chung JE, Egli D, Loh KM, Carter AC, Di Giorgio FP, Koszka K, Huangfu D, Akutsu H, Liu DR, Rubin LL, Eggan KCell stem cellA small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog. Cell Stem Cell. 2009 Nov 06; 5(5):491-503.Cell Stem Cell2009-10-08T00:00:002009A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog.7 Divinity AveHarvard Stem Cell CenterSherman Fairchild Biochemistry Bldg7 Divinity AveCambridge02138MA22705478Hayhurst M, Wagner AK, Cerletti M, Wagers AJ, Rubin LLDevelopmental biologyA cell-autonomous defect in skeletal muscle satellite cells expressing low levels of survival of motor neuron protein. Dev Biol. 2012 Aug 15; 368(2):323-34.Dev Biol2012-06-15T00:00:002012A cell-autonomous defect in skeletal muscle satellite cells expressing low levels of survival of motor neuron protein.23246482Ding Q, Lee YK, Schaefer EA, Peters DT, Veres A, Kim K, Kuperwasser N, Motola DL, Meissner TB, Hendriks WT, Trevisan M, Gupta RM, Moisan A, Banks E, Friesen M, Schinzel RT, Xia F, Tang A, Xia Y, Figueroa E, Wann A, Ahfeldt T, Daheron L, Zhang F, Rubin LL, Peng LF, Chung RT, Musunuru K, Cowan CACell stem cellA TALEN genome-editing system for generating human stem cell-based disease models. Cell Stem Cell. 2013 Feb 07; 12(2):238-51.Cell Stem Cell2012-12-13T00:00:002012A TALEN genome-editing system for generating human stem cell-based disease models.Authorship 10040671128712846Tripathi P, Rodriguez-Muela N, Klim JR, de Boer AS, Agrawal S, Sandoe J, Lopes CS, Ogliari KS, Williams LA, Shear M, Rubin LL, Eggan K, Zhou QStem cell reportsReactive Astrocytes Promote ALS-like Degeneration and Intracellular Protein Aggregation in Human Motor Neurons by Disrupting Autophagy through TGF-ß1. 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