OSI1OleIsacsonOle Isacson, Dr.Med.Sci, M.B.42.39465440000000-71.1956711000000016740Isacson, OleStefan617/855-3283Professor of Neurologycatalyst:eCommonsLogineCommons Loginprns:coAuthorOfcoauthor ofFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:address2address line 2vivo:address3address line 3vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionvivo:hasResearchArearesearch areasvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:middleNamemiddle name or initialvivo:personInPositionpositionsvivo:phoneNumberphonePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titlerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson11193169Isacson O, Lin LAnnals of the New York Academy of SciencesCholinergic modulation of amyloid processing and dementia in animal models of Alzheimer's disease. Ann N Y Acad Sci. 2000; 920:309-14.Ann N Y Acad Sci2000-01-01T00:00:002000Cholinergic modulation of amyloid processing and dementia in animal models of Alzheimer's disease.11829422Williams-Johnso M, Isacson ONeurotoxicologyTherapeutic approaches: session XI summary and research needs. Neurotoxicology. 2001 Dec; 22(6):855-8.Neurotoxicology2001-12-01T00:00:002001Therapeutic approaches: session XI summary and research needs.10416989Isacson OBrain pathology (Zurich, Switzerland)The neurobiology and neurogenetics of stem cells. Brain Pathol. 1999 Jul; 9(3):495-8.Brain Pathol1999-07-01T00:00:001999The neurobiology and neurogenetics of stem cells.11560767Hwang DY, Carlezon WA, Isacson O, Kim KSHuman gene therapyA high-efficiency synthetic promoter that drives transgene expression selectively in noradrenergic neurons. Hum Gene Ther. 2001 Sep 20; 12(14):1731-40.Hum Gene Ther2001-09-20T00:00:002001A high-efficiency synthetic promoter that drives transgene expression selectively in noradrenergic neurons.11987795Costantini LC, Fraefel C, Breakefield XO, Isacson OMethods in molecular medicineHerpes simplex virus/adeno-associated virus hybrid vectors for gene transfer to neurons. Preparation and use. Methods Mol Med. 2002; 69:461-79.Methods Mol Med2002-01-01T00:00:002002Herpes simplex virus/adeno-associated virus hybrid vectors for gene transfer to neurons. Preparation and use.12123857Bimonte HA, Granholm AC, Seo H, Isacson ONeuroscience lettersSpatial memory testing decreases hippocampal amyloid precursor protein in young, but not aged, female rats. Neurosci Lett. 2002 Aug 02; 328(1):50-4.Neurosci Lett2002-08-02T00:00:002002Spatial memory testing decreases hippocampal amyloid precursor protein in young, but not aged, female rats.3601061Isacson O, Fischer W, Wictorin K, Dawbarn D, Björklund ANeuroscienceAstroglial response in the excitotoxically lesioned neostriatum and its projection areas in the rat. Neuroscience. 1987 Mar; 20(3):1043-56.Neuroscience1987-03-01T00:00:001987Astroglial response in the excitotoxically lesioned neostriatum and its projection areas in the rat.2523313Isacson O, Riche D, Hantraye P, Sofroniew MV, Maziere MExperimental brain researchA primate model of Huntington's disease: cross-species implantation of striatal precursor cells to the excitotoxically lesioned baboon caudate-putamen. Exp Brain Res. 1989; 75(1):213-20.Exp Brain Res1989-01-01T00:00:001989A primate model of Huntington's disease: cross-species implantation of striatal precursor cells to the excitotoxically lesioned baboon caudate-putamen.3935983Brundin P, Barbin G, Isacson O, Mallat M, Chamak B, Prochiantz A, Gage FH, Björklund ANeuroscience lettersSurvival of intracerebrally grafted rat dopamine neurons previously cultured in vitro. Neurosci Lett. 1985 Oct 24; 61(1-2):79-84.Neurosci Lett1985-10-24T00:00:001985Survival of intracerebrally grafted rat dopamine neurons previously cultured in vitro.7753372Burns LH, Pakzaban P, Deacon TW, Brownell AL, Tatter SB, Jenkins BG, Isacson ONeuroscienceSelective putaminal excitotoxic lesions in non-human primates model the movement disorder of Huntington disease. Neuroscience. 1995 Feb; 64(4):1007-17.Neuroscience1995-02-01T00:00:001995Selective putaminal excitotoxic lesions in non-human primates model the movement disorder of Huntington disease.8714776Freeman TB, Sanberg PR, Isacson OCell transplantationDevelopment of the human striatum: implications for fetal striatal transplantation in the treatment of Huntington's disease. Cell Transplant. 1995 Nov-Dec; 4(6):539-45.Cell Transplant1995-11-01T00:00:001995Development of the human striatum: implications for fetal striatal transplantation in the treatment of Huntington's disease.17609656Hong S, Hwang DY, Yoon S, Isacson O, Ramezani A, Hawley RG, Kim KSMolecular therapy : the journal of the American Society of Gene TherapyFunctional analysis of various promoters in lentiviral vectors at different stages of in vitro differentiation of mouse embryonic stem cells. Mol Ther. 2007 Sep; 15(9):1630-9.Mol Ther2007-07-03T00:00:002007Functional analysis of various promoters in lentiviral vectors at different stages of in vitro differentiation of mouse embryonic stem cells.17670978Chung CY, Koprich JB, Endo S, Isacson OThe Journal of neuroscience : the official journal of the Society for NeuroscienceAn endogenous serine/threonine protein phosphatase inhibitor, G-substrate, reduces vulnerability in models of Parkinson's disease. J Neurosci. 2007 Aug 01; 27(31):8314-23.J Neurosci2007-08-01T00:00:002007An endogenous serine/threonine protein phosphatase inhibitor, G-substrate, reduces vulnerability in models of Parkinson's disease.11716560Moore AE, Cicchetti F, Hennen J, Isacson OExperimental neurologyParkinsonian motor deficits are reflected by proportional A9/A10 dopamine neuron degeneration in the rat. Exp Neurol. 2001 Dec; 172(2):363-76.Exp Neurol2001-12-01T00:00:002001Parkinsonian motor deficits are reflected by proportional A9/A10 dopamine neuron degeneration in the rat.11876777Seo H, Ferree AW, Isacson OThe European journal of neuroscienceCortico-hippocampal APP and NGF levels are dynamically altered by cholinergic muscarinic antagonist or M1 agonist treatment in normal mice. Eur J Neurosci. 2002 Feb; 15(3):498-506.Eur J Neurosci2002-02-01T00:00:002002Cortico-hippocampal APP and NGF levels are dynamically altered by cholinergic muscarinic antagonist or M1 agonist treatment in normal mice.19965408Isacson OScience (New York, N.Y.)Cell therapy ahead for Parkinson's disease. Science. 2009 Nov 20; 326(5956):1060.Science2009-11-20T00:00:002009Cell therapy ahead for Parkinson's disease.1837849Schumacher JM, Short MP, Hyman BT, Breakefield XO, Isacson ONeuroscienceIntracerebral implantation of nerve growth factor-producing fibroblasts protects striatum against neurotoxic levels of excitatory amino acids. Neuroscience. 1991; 45(3):561-70.Neuroscience1991-01-01T00:00:001991Intracerebral implantation of nerve growth factor-producing fibroblasts protects striatum against neurotoxic levels of excitatory amino acids.18501638Sanchez-Pernaute R, Wang JQ, Kuruppu D, Cao L, Tueckmantel W, Kozikowski A, Isacson O, Brownell ALNeuroImageEnhanced binding of metabotropic glutamate receptor type 5 (mGluR5) PET tracers in the brain of parkinsonian primates. Neuroimage. 2008 Aug 01; 42(1):248-51.Neuroimage2008-04-20T00:00:002008Enhanced binding of metabotropic glutamate receptor type 5 (mGluR5) PET tracers in the brain of parkinsonian primates.19269371Soldner F, Hockemeyer D, Beard C, Gao Q, Bell GW, Cook EG, Hargus G, Blak A, Cooper O, Mitalipova M, Isacson O, Jaenisch RCellParkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors. Cell. 2009 Mar 06; 136(5):964-77.Cell2009-03-06T00:00:002009Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors.19501164Astradsson A, Jenkins BG, Choi JK, Hallett PJ, Levesque MA, McDowell JS, Brownell AL, Spealman RD, Isacson ONeurobiology of diseaseThe blood-brain barrier is intact after levodopa-induced dyskinesias in parkinsonian primates--evidence from in vivo neuroimaging studies. Neurobiol Dis. 2009 Sep; 35(3):348-51.Neurobiol Dis2009-06-06T00:00:002009The blood-brain barrier is intact after levodopa-induced dyskinesias in parkinsonian primates--evidence from in vivo neuroimaging studies.2873538Dunnett SB, Whishaw IQ, Jones GH, Isacson ONeuroscience lettersEffects of dopamine-rich grafts on conditioned rotation in rats with unilateral 6-hydroxydopamine lesions. Neurosci Lett. 1986 Jul 11; 68(1):127-33.Neurosci Lett1986-07-11T00:00:001986Effects of dopamine-rich grafts on conditioned rotation in rats with unilateral 6-hydroxydopamine lesions.22305565Lindvall O, Barker RA, Brüstle O, Isacson O, Svendsen CNCell stem cellClinical translation of stem cells in neurodegenerative disorders. Cell Stem Cell. 2012 Feb 03; 10(2):151-5.Cell Stem Cell2012-02-03T00:00:002012Clinical translation of stem cells in neurodegenerative disorders.2936982Isacson O, Brundin P, Gage FH, Björklund ANeuroscienceNeural grafting in a rat model of Huntington's disease: progressive neurochemical changes after neostriatal ibotenate lesions and striatal tissue grafting. Neuroscience. 1985 Dec; 16(4):799-817.Neuroscience1985-12-01T00:00:001985Neural grafting in a rat model of Huntington's disease: progressive neurochemical changes after neostriatal ibotenate lesions and striatal tissue grafting.3247443Clarke DJ, Dunnett SB, Isacson O, Björklund AProgress in brain researchStriatal grafts in the ibotenic acid-lesioned neostriatum: ultrastructural and immunocytochemical studies. Prog Brain Res. 1988; 78:47-53.Prog Brain Res1988-01-01T00:00:001988Striatal grafts in the ibotenic acid-lesioned neostriatum: ultrastructural and immunocytochemical studies.3284426Gage FH, Brundin P, Strecker R, Dunnett SB, Isacson O, Bjorklund AAnnals of the New York Academy of SciencesIntracerebral neuronal grafting in experimental animal models of age-related motor dysfunction. Ann N Y Acad Sci. 1988; 515:383-94.Ann N Y Acad Sci1988-01-01T00:00:001988Intracerebral neuronal grafting in experimental animal models of age-related motor dysfunction.Authorship 10202827662892Tatter SB, Galpern WR, Hoogeveen AT, Isacson ONeuroreportEffects of striatal excitotoxicity on huntingtin-like immunoreactivity. Neuroreport. 1995 May 30; 6(8):1125-9.Neuroreport1995-05-30T00:00:001995Effects of striatal excitotoxicity on huntingtin-like immunoreactivity.8495711Simpson JR, Isacson OExperimental neurologyMitochondrial impairment reduces the threshold for in vivo NMDA-mediated neuronal death in the striatum. Exp Neurol. 1993 May; 121(1):57-64.Exp Neurol1993-05-01T00:00:001993Mitochondrial impairment reduces the threshold for in vivo NMDA-mediated neuronal death in the striatum.17369255Zhang J, Vinuela A, Neely MH, Hallett PJ, Grant SG, Miller GM, Isacson O, Caron MG, Yao WDThe Journal of biological chemistryInhibition of the dopamine D1 receptor signaling by PSD-95. J Biol Chem. 2007 May 25; 282(21):15778-89.J Biol Chem2007-03-16T00:00:002007Inhibition of the dopamine D1 receptor signaling by PSD-95.Authorship 1064169829735433Hallett PJ, Huebecker M, Brekk OR, Moloney EB, Rocha EM, Priestman DA, Platt FM, Isacson ONeurobiology of agingGlycosphingolipid levels and glucocerebrosidase activity are altered in normal aging of the mouse brain. Neurobiol Aging. 2018 07; 67:189-200.Neurobiol Aging2018-03-29T00:00:002018Glycosphingolipid levels and glucocerebrosidase activity are altered in normal aging of the mouse brain.2460191Nothias F, Wictorin K, Isacson O, Björklund A, Peschanski MBrain researchMorphological alteration of thalamic afferents in the excitotoxically lesioned striatum. Brain Res. 1988 Oct 04; 461(2):349-54.Brain Res1988-10-04T00:00:001988Morphological alteration of thalamic afferents in the excitotoxically lesioned striatum.19261890Zhang J, Xu TX, Hallett PJ, Watanabe M, Grant SG, Isacson O, Yao WDThe Journal of neuroscience : the official journal of the Society for NeurosciencePSD-95 uncouples dopamine-glutamate interaction in the D1/PSD-95/NMDA receptor complex. J Neurosci. 2009 Mar 04; 29(9):2948-60.J Neurosci2009-03-04T00:00:002009PSD-95 uncouples dopamine-glutamate interaction in the D1/PSD-95/NMDA receptor complex.20826431Hedlund E, Karlsson M, Osborn T, Ludwig W, Isacson OBrain : a journal of neurologyGlobal gene expression profiling of somatic motor neuron populations with different vulnerability identify molecules and pathways of degeneration and protection. Brain. 2010 Aug; 133(Pt 8):2313-30.Brain2010-08-01T00:00:002010Global gene expression profiling of somatic motor neuron populations with different vulnerability identify molecules and pathways of degeneration and protection.12167769McNaught KS, Björklund LM, Belizaire R, Isacson O, Jenner P, Olanow CWNeuroreportProteasome inhibition causes nigral degeneration with inclusion bodies in rats. Neuroreport. 2002 Aug 07; 13(11):1437-41.Neuroreport2002-08-07T00:00:002002Proteasome inhibition causes nigral degeneration with inclusion bodies in rats.1688664Sofroniew MV, Galletly NP, Isacson O, Svendsen CNScience (New York, N.Y.)Survival of adult basal forebrain cholinergic neurons after loss of target neurons. Science. 1990 Jan 19; 247(4940):338-42.Science1990-01-19T00:00:001990Survival of adult basal forebrain cholinergic neurons after loss of target neurons.22764206Cooper O, Seo H, Andrabi S, Guardia-Laguarta C, Graziotto J, Sundberg M, McLean JR, Carrillo-Reid L, Xie Z, Osborn T, Hargus G, Deleidi M, Lawson T, Bogetofte H, Perez-Torres E, Clark L, Moskowitz C, Mazzulli J, Chen L, Volpicelli-Daley L, Romero N, Jiang H, Uitti RJ, Huang Z, Opala G, Scarffe LA, Dawson VL, Klein C, Feng J, Ross OA, Trojanowski JQ, Lee VM, Marder K, Surmeier DJ, Wszolek ZK, Przedborski S, Krainc D, Dawson TM, Isacson OScience translational medicinePharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease. Sci Transl Med. 2012 Jul 04; 4(141):141ra90.Sci Transl Med2012-07-04T00:00:002012Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease.17726113Inoue H, Lin L, Lee X, Shao Z, Mendes S, Snodgrass-Belt P, Sweigard H, Engber T, Pepinsky B, Yang L, Beal MF, Mi S, Isacson OProceedings of the National Academy of Sciences of the United States of AmericaInhibition of the leucine-rich repeat protein LINGO-1 enhances survival, structure, and function of dopaminergic neurons in Parkinson's disease models. Proc Natl Acad Sci U S A. 2007 Sep 04; 104(36):14430-5.Proc Natl Acad Sci U S A2007-08-28T00:00:002007Inhibition of the leucine-rich repeat protein LINGO-1 enhances survival, structure, and function of dopaminergic neurons in Parkinson's disease models.2306616O'Brien TS, Svendsen CN, Isacson O, Sofroniew MVBrain researchLoss of true blue labelling from the medial septum following transection of the fimbria-fornix: evidence for the death of cholinergic and non-cholinergic neurons. Brain Res. 1990 Feb 05; 508(2):249-56.Brain Res1990-02-05T00:00:001990Loss of true blue labelling from the medial septum following transection of the fimbria-fornix: evidence for the death of cholinergic and non-cholinergic neurons.10549790Chen YI, Brownell AL, Galpern W, Isacson O, Bogdanov M, Beal MF, Livni E, Rosen BR, Jenkins BGNeuroreportDetection of dopaminergic cell loss and neural transplantation using pharmacological MRI, PET and behavioral assessment. Neuroreport. 1999 Sep 29; 10(14):2881-6.Neuroreport1999-09-29T00:00:001999Detection of dopaminergic cell loss and neural transplantation using pharmacological MRI, PET and behavioral assessment.12432781Björklund LM, Isacson OProgress in brain researchRegulation of dopamine cell type and transmitter function in fetal and stem cell transplantation for Parkinson's disease. Prog Brain Res. 2002; 138:411-20.Prog Brain Res2002-01-01T00:00:002002Regulation of dopamine cell type and transmitter function in fetal and stem cell transplantation for Parkinson's disease.12535224Cicchetti F, Fodor W, Deacon TW, van Horne C, Rollins S, Burton W, Costantini LC, Isacson OXenotransplantationImmune parameters relevant to neural xenograft survival in the primate brain. Xenotransplantation. 2003 Jan; 10(1):41-9.Xenotransplantation2003-01-01T00:00:002003Immune parameters relevant to neural xenograft survival in the primate brain.3247459Peschanski M, Rudin M, Isacson O, Delepierre M, Roques BPProgress in brain researchMagnetic resonance imaging of intracerebral neural grafts. Prog Brain Res. 1988; 78:619-24.Prog Brain Res1988-01-01T00:00:001988Magnetic resonance imaging of intracerebral neural grafts.8393409Wüllner U, Brouillet E, Isacson O, Young AB, Penney JBExperimental neurologyGlutamate receptor binding sites in MPTP-treated mice. Exp Neurol. 1993 Jun; 121(2):284-7.Exp Neurol1993-06-01T00:00:001993Glutamate receptor binding sites in MPTP-treated mice.3554356Sofroniew MV, Pearson RC, Isacson O, Björklund AProgress in brain researchExperimental studies on the induction and prevention of retrograde degeneration of basal forebrain cholinergic neurons. Prog Brain Res. 1986; 70:363-89.Prog Brain Res1986-01-01T00:00:001986Experimental studies on the induction and prevention of retrograde degeneration of basal forebrain cholinergic neurons.2898109Clarke DJ, Dunnett SB, Isacson O, Sirinathsinghji DJ, Björklund ANeuroscienceStriatal grafts in rats with unilateral neostriatal lesions--I. Ultrastructural evidence of afferent synaptic inputs from the host nigrostriatal pathway. Neuroscience. 1988 Mar; 24(3):791-801.Neuroscience1988-03-01T00:00:001988Striatal grafts in rats with unilateral neostriatal lesions--I. Ultrastructural evidence of afferent synaptic inputs from the host nigrostriatal pathway.14750653Granholm AC, Sanders L, Seo H, Lin L, Ford K, Isacson OHippocampusEstrogen alters amyloid precursor protein as well as dendritic and cholinergic markers in a mouse model of Down syndrome. Hippocampus. 2003; 13(8):905-14.Hippocampus2003-01-01T00:00:002003Estrogen alters amyloid precursor protein as well as dendritic and cholinergic markers in a mouse model of Down syndrome.15483111Cooper O, Isacson OThe Journal of neuroscience : the official journal of the Society for NeuroscienceIntrastriatal transforming growth factor alpha delivery to a model of Parkinson's disease induces proliferation and migration of endogenous adult neural progenitor cells without differentiation into dopaminergic neurons. J Neurosci. 2004 Oct 13; 24(41):8924-31.J Neurosci2004-10-13T00:00:002004Intrastriatal transforming growth factor alpha delivery to a model of Parkinson's disease induces proliferation and migration of endogenous adult neural progenitor cells without differentiation into dopaminergic neurons.2290944Sofroniew MV, Dunnett SB, Isacson OProgress in brain researchRemodelling of intrinsic and afferent systems in neocortex with cortical transplants. Prog Brain Res. 1990; 82:313-20.Prog Brain Res1990-01-01T00:00:001990Remodelling of intrinsic and afferent systems in neocortex with cortical transplants.18304357Koprich JB, Reske-Nielsen C, Mithal P, Isacson OJournal of neuroinflammationNeuroinflammation mediated by IL-1beta increases susceptibility of dopamine neurons to degeneration in an animal model of Parkinson's disease. J Neuroinflammation. 2008 Feb 27; 5:8.J Neuroinflammation2008-02-27T00:00:002008Neuroinflammation mediated by IL-1beta increases susceptibility of dopamine neurons to degeneration in an animal model of Parkinson's disease.Authorship 114312218978995Isacson OJournal of visualized experiments : JoVEOle Isacson: development of new therapies for Parkinson's disease (interview). J Vis Exp. 2007; (3):189.J Vis Exp2007-04-29T00:00:002007Ole Isacson: development of new therapies for Parkinson's disease (interview).3214743Lams BE, Isacson O, Sofroniew MVBrain researchLoss of transmitter-associated enzyme staining following axotomy does not indicate death of brainstem cholinergic neurons. Brain Res. 1988 Dec 20; 475(2):401-6.Brain Res1988-12-20T00:00:001988Loss of transmitter-associated enzyme staining following axotomy does not indicate death of brainstem cholinergic neurons.18341409Astradsson A, Cooper O, Vinuela A, Isacson ONeurosurgical focusRecent advances in cell-based therapy for Parkinson disease. Neurosurg Focus. 2008; 24(3-4):E6.Neurosurg Focus2008-01-01T00:00:002008Recent advances in cell-based therapy for Parkinson disease.23195423Cooper O, Parmar M, Isacson OProgress in brain researchCharacterization and criteria of embryonic stem and induced pluripotent stem cells for a dopamine replacement therapy. Prog Brain Res. 2012; 200:265-76.Prog Brain Res2012-01-01T00:00:002012Characterization and criteria of embryonic stem and induced pluripotent stem cells for a dopamine replacement therapy.3247439Fischer W, Wictorin K, Isacson O, Björklund AProgress in brain researchTrophic effects on cholinergic striatal interneurons by submaxillary gland transplants. Prog Brain Res. 1988; 78:409-12.Prog Brain Res1988-01-01T00:00:001988Trophic effects on cholinergic striatal interneurons by submaxillary gland transplants.Authorship 10221512475937Dunnett S, Isacson OTrends in neurosciencesTrophic mechanisms are not enough. Trends Neurosci. 1989 Jul; 12(7):257.Trends Neurosci1989-07-01T00:00:001989Trophic mechanisms are not enough.18556510de Chevigny A, Cooper O, Vinuela A, Reske-Nielsen C, Lagace DC, Eisch AJ, Isacson OStem cells (Dayton, Ohio)Fate mapping and lineage analyses demonstrate the production of a large number of striatal neuroblasts after transforming growth factor alpha and noggin striatal infusions into the dopamine-depleted striatum. Stem Cells. 2008 Sep; 26(9):2349-60.Stem Cells2008-06-12T00:00:002008Fate mapping and lineage analyses demonstrate the production of a large number of striatal neuroblasts after transforming growth factor alpha and noggin striatal infusions into the dopamine-depleted striatum.18640989Seo H, Kim W, Isacson OHuman molecular geneticsCompensatory changes in the ubiquitin-proteasome system, brain-derived neurotrophic factor and mitochondrial complex II/III in YAC72 and R6/2 transgenic mice partially model Huntington's disease patients. Hum Mol Genet. 2008 Oct 15; 17(20):3144-53.Hum Mol Genet2008-07-17T00:00:002008Compensatory changes in the ubiquitin-proteasome system, brain-derived neurotrophic factor and mitochondrial complex II/III in YAC72 and R6/2 transgenic mice partially model Huntington's disease patients.19162339Lin L, Lesnick TG, Maraganore DM, Isacson OTrends in neurosciencesAxon guidance and synaptic maintenance: preclinical markers for neurodegenerative disease and therapeutics. Trends Neurosci. 2009 Mar; 32(3):142-9.Trends Neurosci2009-01-21T00:00:002009Axon guidance and synaptic maintenance: preclinical markers for neurodegenerative disease and therapeutics.20007772Chung CY, Koprich JB, Hallett PJ, Isacson OProceedings of the National Academy of Sciences of the United States of AmericaFunctional enhancement and protection of dopaminergic terminals by RAB3B overexpression. Proc Natl Acad Sci U S A. 2009 Dec 29; 106(52):22474-9.Proc Natl Acad Sci U S A2009-12-10T00:00:002009Functional enhancement and protection of dopaminergic terminals by RAB3B overexpression.20698932Seo H, Isacson OJournal of neurochemistryThe hAPP-YAC transgenic model has elevated UPS activity in the frontal cortex similar to Alzheimer's disease and Down's syndrome. J Neurochem. 2010 Sep; 114(6):1819-26.J Neurochem2010-08-03T00:00:002010The hAPP-YAC transgenic model has elevated UPS activity in the frontal cortex similar to Alzheimer's disease and Down's syndrome.21608081Deleidi M, Hargus G, Hallett P, Osborn T, Isacson OStem cells (Dayton, Ohio)Development of histocompatible primate-induced pluripotent stem cells for neural transplantation. Stem Cells. 2011 Jul; 29(7):1052-63.Stem Cells2011-07-01T00:00:002011Development of histocompatible primate-induced pluripotent stem cells for neural transplantation.Authorship 1090248430149180Moloney EB, Moskites A, Ferrari EJ, Isacson O, Hallett PJNeurobiology of diseaseThe glycoprotein GPNMB is selectively elevated in the substantia nigra of Parkinson's disease patients and increases after lysosomal stress. Neurobiol Dis. 2018 12; 120:1-11.Neurobiol Dis2018-08-24T00:00:002018The glycoprotein GPNMB is selectively elevated in the substantia nigra of Parkinson's disease patients and increases after lysosomal stress.3730884Sofroniew MV, Isacson O, Björklund ABrain researchCortical grafts prevent atrophy of cholinergic basal nucleus neurons induced by excitotoxic cortical damage. Brain Res. 1986 Jul 23; 378(2):409-15.Brain Res1986-07-23T00:00:001986Cortical grafts prevent atrophy of cholinergic basal nucleus neurons induced by excitotoxic cortical damage.4058805Gage FH, Brundin P, Isacson O, Björklund ANeuroscience lettersRat fetal brain tissue grafts survive and innervate host brain following five day pregraft tissue storage. Neurosci Lett. 1985 Sep 30; 60(2):133-7.Neurosci Lett1985-09-30T00:00:001985Rat fetal brain tissue grafts survive and innervate host brain following five day pregraft tissue storage.6389079Gage FH, Dunnett SB, Brundin P, Isacson O, Björklund ADevelopmental neuroscienceIntracerebral grafting of embryonic neural cells into the adult host brain: an overview of the cell suspension method and its application. Dev Neurosci. 1983-1984; 6(3):137-51.Dev Neurosci1983-01-01T00:00:001983Intracerebral grafting of embryonic neural cells into the adult host brain: an overview of the cell suspension method and its application.8395405Yee WM, Frim DM, Isacson OExperimental brain researchRelationships between stress protein induction and NMDA-mediated neuronal death in the entorhinal cortex. Exp Brain Res. 1993; 94(2):193-202.Exp Brain Res1993-01-01T00:00:001993Relationships between stress protein induction and NMDA-mediated neuronal death in the entorhinal cortex.8421209Frim DM, Short MP, Rosenberg WS, Simpson J, Breakefield XO, Isacson OJournal of neurosurgeryLocal protective effects of nerve growth factor-secreting fibroblasts against excitotoxic lesions in the rat striatum. J Neurosurg. 1993 Feb; 78(2):267-73.J Neurosurg1993-02-01T00:00:001993Local protective effects of nerve growth factor-secreting fibroblasts against excitotoxic lesions in the rat striatum.19731556Pruszak J, Isacson OAdvances in experimental medicine and biologyMolecular and cellular determinants for generating ES-cell derived dopamine neurons for cell therapy. Adv Exp Med Biol. 2009; 651:112-23.Adv Exp Med Biol2009-01-01T00:00:002009Molecular and cellular determinants for generating ES-cell derived dopamine neurons for cell therapy.20603216Cooper O, Hargus G, Deleidi M, Blak A, Osborn T, Marlow E, Lee K, Levy A, Perez-Torres E, Yow A, Isacson OMolecular and cellular neurosciencesDifferentiation of human ES and Parkinson's disease iPS cells into ventral midbrain dopaminergic neurons requires a high activity form of SHH, FGF8a and specific regionalization by retinoic acid. Mol Cell Neurosci. 2010 Nov; 45(3):258-66.Mol Cell Neurosci2010-07-24T00:00:002010Differentiation of human ES and Parkinson's disease iPS cells into ventral midbrain dopaminergic neurons requires a high activity form of SHH, FGF8a and specific regionalization by retinoic acid.20823871Isacson O, Mendez INature medicineBeing too inclusive about synuclein inclusions. Nat Med. 2010 Sep; 16(9):960-1; author reply 961.Nat Med2010-09-01T00:00:002010Being too inclusive about synuclein inclusions.2939457Isacson O, Dunnett SB, Björklund AProceedings of the National Academy of Sciences of the United States of AmericaGraft-induced behavioral recovery in an animal model of Huntington disease. 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Neuroscience. 1995 Apr; 65(4):983-96.Neuroscience1995-04-01T00:00:001995A novel mode of immunoprotection of neural xenotransplants: masking of donor major histocompatibility complex class I enhances transplant survival in the central nervous system.7907548Pakzaban P, Deacon TW, Burns LH, Isacson OExperimental brain researchIncreased proportion of acetylcholinesterase-rich zones and improved morphological integration in host striatum of fetal grafts derived from the lateral but not the medial ganglionic eminence. 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Schwarzschild, M.D., Ph.D.42.37904200000000-71.0514810000000019322Schwarzschild, MichaelJulieanne Dorn Professor of Neurology11300selected publications7.896420.00153602802research areas8.436340.0073822431coauthor of171.73533.323660similar toDJS1DennisSelkoeDennis J. Selkoe, M.D.42.33837200000000-71.1032690000000081795Selkoe, DennisVincent and Stella Coates Professor of Neurologic Diseases in the Department of NeurologyPJH6PenelopeHallettPenelope Jane Hallett, Ph.D.42.39465440000000-71.195671100000001887Hallett, PenelopeAssociate Professor of PsychiatryBHP1BrucePriceBruce H. Price, M.D.42.39465440000000-71.1956711000000051563Price, BruceAssociate Professor of NeurologyAB23Anna-LiisaBrownellAnna-Liisa Brownell, Ph.D.42.36241700000000-71.0689370000000066067Brownell, Anna-LiisaProfessor of RadiologyBTH2BradleyHymanBradley Theodore Hyman, M.D., Ph.D.42.37904200000000-71.051481000000004393Hyman, BradleyJohn B. Penney, Jr. Professor of NeurologyLSZ1LindaZamvilLinda Susan Zamvil, M.D.42.39465440000000-71.1956711000000064015Zamvil, LindaAssistant Professor of Psychiatry, Part-timeOJC1OliverCooperOliver Jamie Cooper, Ph.D.42.39465440000000-71.1956711000000042292Cooper, OliverInstructor in PsychiatryGQD1GeorgeDaleyGeorge Quentin Daley, M.D., Ph.D.42.33812600000000-71.1049210000000062Daley, GeorgeCaroline Shields Walker Professor of MedicineKS14Kai-ChristianSonntagKai-Christian Sonntag, M.D., Ph.D.42.39465440000000-71.1956711000000046475Sonntag, Kai-ChristianAssistant Professor of PsychiatryABA3AlbertoAscherioAlberto B. Ascherio, D.P.H., M.D.42.34307730000000-71.0552292000000036351Ascherio, AlbertoProfessor of Epidemiology and NutritionAuthorship 1265174MBK2MarianKlepserMarian Baldrige Klepser, M.D.42.39465440000000-71.1956711000000029857Klepser, MarianAssistant Professor of MedicineRK41RakeshKarmacharyaRakesh Karmacharya, M.D.,Ph.D.42.39465440000000-71.1956711000000023952Karmacharya, RakeshAssociate Professor of PsychiatryMPP6MonaPotterMona Patel Potter, M.D.42.39465440000000-71.1956711000000028659Potter, MonaLecturer on Psychiatry, Part-timeAuthorship 1409331Authorship 1167453931261377Korecka JA, Thomas R, Christensen DP, Hinrich AJ, Ferrari EJ, Levy SA, Hastings ML, Hallett PJ, Isacson OHuman molecular geneticsMitochondrial clearance and maturation of autophagosomes are compromised in LRRK2 G2019S familial Parkinson's disease patient fibroblasts. Hum Mol Genet. 2019 10 01; 28(19):3232-3243.Hum Mol Genet2019-10-01T00:00:002019Mitochondrial clearance and maturation of autophagosomes are compromised in LRRK2 G2019S familial Parkinson's disease patient fibroblasts.Authorship 1407123Authorship 1175632331331333Hallett PJ, Engelender S, Isacson OJournal of neuroinflammationLipid and immune abnormalities causing age-dependent neurodegeneration and Parkinson's disease. J Neuroinflammation. 2019 Jul 22; 16(1):153.J Neuroinflammation2019-07-22T00:00:002019Lipid and immune abnormalities causing age-dependent neurodegeneration and Parkinson's disease.Authorship 1179724831381839Menon V, Thomas R, Elgueta C, Horl M, Osborn T, Hallett PJ, Bartos M, Isacson O, Pruszak JStem cells (Dayton, Ohio)Comprehensive Cell Surface Antigen Analysis Identifies Transferrin Receptor Protein-1 (CD71) as a Negative Selection Marker for Human Neuronal Cells. Stem Cells. 2019 10; 37(10):1293-1306.Stem Cells2019-08-09T00:00:002019Comprehensive Cell Surface Antigen Analysis Identifies Transferrin Receptor Protein-1 (CD71) as a Negative Selection Marker for Human Neuronal Cells.Authorship 1417823Authorship 1435063Authorship 1345072Authorship 1201533Authorship 1199916131649605Isacson O, Brekk OR, Hallett PJFrontiers in neurologyNovel Results and Concepts Emerging From Lipid Cell Biology Relevant to Degenerative Brain Aging and Disease. Front Neurol. 2019; 10:1053.Front Neurol2019-10-09T00:00:002019Novel Results and Concepts Emerging From Lipid Cell Biology Relevant to Degenerative Brain Aging and Disease.Authorship 1202965531703585Huebecker M, Moloney EB, van der Spoel AC, Priestman DA, Isacson O, Hallett PJ, Platt FMMolecular neurodegenerationReduced sphingolipid hydrolase activities, substrate accumulation and ganglioside decline in Parkinson's disease. Mol Neurodegener. 2019 11 08; 14(1):40.Mol Neurodegener2019-11-08T00:00:002019Reduced sphingolipid hydrolase activities, substrate accumulation and ganglioside decline in Parkinson's disease.true1Assistant Professor of PsychiatryAssistant Professor of Psychiatrytrue1Professor of RadiologyProfessor of Radiologytrue1Julieanne Dorn Professor of NeurologyJulieanne Dorn Professor of Neurologytrue1Assistant Professor of MedicineAssistant Professor of Medicinetrue1John B. Penney, Jr. Professor of NeurologyJohn B. Penney, Jr. Professor of Neurologytrue1Professor of NeurologyProfessor of Neurologytrue1Associate Professor of PsychiatryAssociate Professor of Psychiatrytrue1Assistant Professor of Psychiatry, Part-timeAssistant Professor of Psychiatry, Part-timetrue1Vincent and Stella Coates Professor of Neurologic Diseases in the Department of NeurologyVincent and Stella Coates Professor of Neurologic Diseases in the Department of NeurologyAuthorship 1183862Authorship 1194922Authorship 1198338Authorship 1230415Authorship 1218355531937358Huebecker M, Moloney EB, van der Spoel AC, Priestman DA, Isacson O, Hallett PJ, Platt FMMolecular neurodegenerationCorrection to: Reduced sphingolipid hydrolase activities, substrate accumulation and ganglioside decline in Parkinson's disease. Mol Neurodegener. 2020 Jan 15; 15(1):6.Mol Neurodegener2020-01-15T00:00:002020Correction to: Reduced sphingolipid hydrolase activities, substrate accumulation and ganglioside decline in Parkinson's disease.Authorship 1781351Authorship 1639834Authorship 174884632317934Osborn TM, Hallett PJ, Schumacher JM, Isacson OFrontiers in cellular neuroscienceAdvantages and Recent Developments of Autologous Cell Therapy for Parkinson's Disease Patients. Front Cell Neurosci. 2020; 14:58.Front Cell Neurosci2020-04-03T00:00:002020Advantages and Recent Developments of Autologous Cell Therapy for Parkinson's Disease Patients.Authorship 12412224Authorship 185881Authorship 1752113Authorship 1368992Authorship 1270781732736291Korecka JA, Thomas R, Hinrich AJ, Moskites AM, Macbain ZK, Hallett PJ, Isacson O, Hastings MLMolecular therapy. Nucleic acidsSplice-Switching Antisense Oligonucleotides Reduce LRRK2 Kinase Activity in Human LRRK2 Transgenic Mice. Mol Ther Nucleic Acids. 2020 Sep 04; 21:623-635.Mol Ther Nucleic Acids2020-06-27T00:00:002020Splice-Switching Antisense Oligonucleotides Reduce LRRK2 Kinase Activity in Human LRRK2 Transgenic Mice.Authorship 127330010Authorship 1275216332739007Thomas R, Hallett PJ, Isacson OInternational review of neurobiologyExperimental studies of mitochondrial and lysosomal function in in vitro and in vivo models relevant to Parkinson's disease genetic risk. Int Rev Neurobiol. 2020; 154:279-302.Int Rev Neurobiol2020-07-10T00:00:002020Experimental studies of mitochondrial and lysosomal function in in vitro and in vivo models relevant to Parkinson's disease genetic risk.32762772Brekk OR, Korecka JA, Crapart CC, Huebecker M, MacBain ZK, Rosenthal SA, Sena-Esteves M, Priestman DA, Platt FM, Isacson O, Hallett PJActa neuropathologica communicationsUpregulating ß-hexosaminidase activity in rodents prevents a-synuclein lipid associations and protects dopaminergic neurons from a-synuclein-mediated neurotoxicity. Acta Neuropathol Commun. 2020 08 06; 8(1):127.Acta Neuropathol Commun2020-08-06T00:00:002020Upregulating ß-hexosaminidase activity in rodents prevents a-synuclein lipid associations and protects dopaminergic neurons from a-synuclein-mediated neurotoxicity.Authorship 1277683132793108Isacson OFrontiers in neurologyThe Consequences of Coronavirus-Induced Cytokine Storm Are Associated With Neurological Diseases, Which May Be Preventable. Front Neurol. 2020; 11:745.Front Neurol2020-07-24T00:00:002020The Consequences of Coronavirus-Induced Cytokine Storm Are Associated With Neurological Diseases, Which May Be Preventable.Authorship 2016702BCMPAuthorship 1491985Authorship 1492625Authorship 1294946533060302Brekk OR, Honey JR, Lee S, Hallett PJ, Isacson OProceedings of the National Academy of Sciences of the United States of AmericaCell type-specific lipid storage changes in Parkinson's disease patient brains are recapitulated by experimental glycolipid disturbance. Proc Natl Acad Sci U S A. 2020 11 03; 117(44):27646-27654.Proc Natl Acad Sci U S A2020-10-15T00:00:002020Cell type-specific lipid storage changes in Parkinson's disease patient brains are recapitulated by experimental glycolipid disturbance.Authorship 1389122Authorship 1455161Authorship 1506085Authorship 1322543533468204Thomas R, Moloney EB, Macbain ZK, Hallett PJ, Isacson OMolecular brainFibroblasts from idiopathic Parkinson's disease exhibit deficiency of lysosomal glucocerebrosidase activity associated with reduced levels of the trafficking receptor LIMP2. Mol Brain. 2021 01 19; 14(1):16.Mol Brain2021-01-19T00:00:002021Fibroblasts from idiopathic Parkinson's disease exhibit deficiency of lysosomal glucocerebrosidase activity associated with reduced levels of the trafficking receptor LIMP2.Authorship 1592322Authorship 201363Authorship 1545111Authorship 2267407true1Associate Professor of PsychiatryAssociate Professor of PsychiatryAuthorship 1835904Authorship 1662681Authorship 1888841Authorship 181254Authorship 1409941734757540Wallom KL, Fernández-Suárez ME, Priestman DA, Te Vruchte D, Huebecker M, Hallett PJ, Isacson O, Platt FMGlycoconjugate journalGlycosphingolipid metabolism and its role in ageing and Parkinson's disease. Glycoconj J. 2022 02; 39(1):39-53.Glycoconj J2021-11-10T00:00:002021Glycosphingolipid metabolism and its role in ageing and Parkinson's disease.Authorship 1464814Authorship 2530631Authorship 2621766Authorship 2883285true1Associate Professor of NeurologyAssociate Professor of Neurologytrue1Instructor in PsychiatryInstructor in PsychiatryAuthorship 15581841Authorship 3955785Authorship 4017524Authorship 1485274336165619Cooper O, Hallett P, Isacson OThe FEBS journalUpstream lipid and metabolic systems are potential causes of Alzheimer's disease, Parkinson's disease and dementias. FEBS J. 2024 Feb; 291(4):632-645.FEBS J2022-10-12T00:00:002022Upstream lipid and metabolic systems are potential causes of Alzheimer's disease, Parkinson's disease and dementias.Authorship 1525689536752535Kumar M, Srikanth MP, Deleidi M, Hallett PJ, Isacson O, Feldman RAHuman molecular geneticsAcid ceramidase involved in pathogenic cascade leading to accumulation of a-synuclein in iPSC model of GBA1-associated Parkinson's disease. Hum Mol Genet. 2023 05 18; 32(11):1888-1900.Hum Mol Genet2023-05-18T00:00:002023Acid ceramidase involved in pathogenic cascade leading to accumulation of a-synuclein in iPSC model of GBA1-associated Parkinson's disease.Authorship 4833594Authorship 4971735Authorship 15660803537214873Cronin SJF, Yu W, Hale A, Licht-Mayer S, Crabtree MJ, Korecka JA, Tretiakov EO, Sealey-Cardona M, Somlyay M, Onji M, An M, Fox JD, Turnes BL, Gomez-Diaz C, da Luz Scheffer D, Cikes D, Nagy V, Weidinger A, Wolf A, Reither H, Chabloz A, Kavirayani A, Rao S, Andrews N, Latremoliere A, Costigan M, Douglas G, Freitas FC, Pifl C, Walz R, Konrat R, Mahad DJ, Koslov AV, Latini A, Isacson O, Harkany T, Hallett PJ, Bagby S, Woolf CJ, Channon KM, Je HS, Penninger JMbioRxiv : the preprint server for biologyCrucial neuroprotective roles of the metabolite BH4 in dopaminergic neurons. bioRxiv. 2023 May 08.bioRxiv2023-05-08T00:00:002023Crucial neuroprotective roles of the metabolite BH4 in dopaminergic neurons.Authorship 2814072Authorship 2101835true1Assistant Professor of NeurologyAssistant Professor of NeurologyAuthorship 1587899637704739Thomas R, Connolly KJ, Brekk OR, Hinrich AJ, Hastings ML, Isacson O, Hallett PJScientific reportsViral-like TLR3 induction of cytokine networks and a-synuclein are reduced by complement C3 blockade in mouse brain. Sci Rep. 2023 09 13; 13(1):15164.Sci Rep2023-09-13T00:00:002023Viral-like TLR3 induction of cytokine networks and a-synuclein are reduced by complement C3 blockade in mouse brain.Authorship 4365856Authorship 4453994Authorship 4611748Authorship 1605760637947642Connolly KJ, Margaria J, Di Biase E, Cooper O, Hallett PJ, Isacson OCellsLoss of Lipid Carrier ApoE Exacerbates Brain Glial and Inflammatory Responses after Lysosomal GBA1 Inhibition. Cells. 2023 11 02; 12(21).Cells2023-11-02T00:00:002023Loss of Lipid Carrier ApoE Exacerbates Brain Glial and Inflammatory Responses after Lysosomal GBA1 Inhibition.Authorship 4917604Authorship 5629179true1Lecturer on Psychiatry, Part-timeLecturer on Psychiatry, Part-timeAuthorship 2142682Authorship 2343961true1Caroline Shields Walker Professor of MedicineCaroline Shields Walker Professor of Medicinetrue1Professor of Epidemiology and NutritionProfessor of Epidemiology and NutritionAuthorship 1730503Authorship 323741Authorship 3415358Authorship 3672582Authorship 2379483Authorship 4564293Authorship 2663231Authorship 2719372Authorship 180023Authorship 186451Authorship 2024805Authorship 6777051223666606Sundberg M, Bogetofte H, Lawson T, Jansson J, Smith G, Astradsson A, Moore M, Osborn T, Cooper O, Spealman R, Hallett P, Isacson OStem cells (Dayton, Ohio)Improved cell therapy protocols for Parkinson's disease based on differentiation efficiency and safety of hESC-, hiPSC-, and non-human primate iPSC-derived dopaminergic neurons. Stem Cells. 2013 Aug; 31(8):1548-62.Stem Cells2013-08-01T00:00:002013Improved cell therapy protocols for Parkinson's disease based on differentiation efficiency and safety of hESC-, hiPSC-, and non-human primate iPSC-derived dopaminergic neurons.Authorship 24782210Authorship 3342593Authorship 2052273Authorship 1960343Authorship 6999711524148854Sanders LH, Laganière J, Cooper O, Mak SK, Vu BJ, Huang YA, Paschon DE, Vangipuram M, Sundararajan R, Urnov FD, Langston JW, Gregory PD, Zhang HS, Greenamyre JT, Isacson O, Schüle BNeurobiology of diseaseLRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: reversal by gene correction. Neurobiol Dis. 2014 Feb; 62:381-6.Neurobiol Dis2013-10-19T00:00:002013LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: reversal by gene correction.Authorship 2111342Authorship 2393304JAK60JoannaKorecka-RoetJoanna A Korecka-Roet, Ph.D.124254Korecka-Roet, JoannaAssistant Professor of NeurologyAuthorship 2373825Authorship 2414875Authorship 4170242Authorship 671804Authorship 2855802Authorship 428321324437368Sundberg M, Isacson OExpert opinion on biological therapyAdvances in stem-cell--generated transplantation therapy for Parkinson's disease. Expert Opin Biol Ther. 2014 Apr; 14(4):437-53.Expert Opin Biol Ther2014-04-01T00:00:002014Advances in stem-cell--generated transplantation therapy for Parkinson's disease.Authorship 725150924388974Davies SE, Hallett PJ, Moens T, Smith G, Mangano E, Kim HT, Goldberg AL, Liu JL, Isacson O, Tofaris GKNeurobiology of diseaseEnhanced ubiquitin-dependent degradation by Nedd4 protects against a-synuclein accumulation and toxicity in animal models of Parkinson's disease. Neurobiol Dis. 2014 Apr; 64:79-87.Neurobiol Dis2013-12-31T00:00:002013Enhanced ubiquitin-dependent degradation by Nedd4 protects against a-synuclein accumulation and toxicity in animal models of Parkinson's disease.Authorship 2111376Authorship 954355Authorship 7274942Authorship 3115094Authorship 729565724702501Zhang J, Saur T, Duke AN, Grant SG, Platt DM, Rowlett JK, Isacson O, Yao WDJournal of neurogeneticsMotor impairments, striatal degeneration, and altered dopamine-glutamate interplay in mice lacking PSD-95. J Neurogenet. 2014 Mar-Jun; 28(1-2):98-111.J Neurogenet2014-04-22T00:00:002014Motor impairments, striatal degeneration, and altered dopamine-glutamate interplay in mice lacking PSD-95.Authorship 2809110Authorship 1713803Authorship 738956624910427Hallett PJ, Cooper O, Sadi D, Robertson H, Mendez I, Isacson OCell reportsLong-term health of dopaminergic neuron transplants in Parkinson's disease patients. Cell Rep. 2014 Jun 26; 7(6):1755-61.Cell Rep2014-06-06T00:00:002014Long-term health of dopaminergic neuron transplants in Parkinson's disease patients.Authorship 744497724882721McLean JR, Smith GA, Rocha EM, Hayes MA, Beagan JA, Hallett PJ, Isacson ONeuroscience lettersWidespread neuron-specific transgene expression in brain and spinal cord following synapsin promoter-driven AAV9 neonatal intracerebroventricular injection. Neurosci Lett. 2014 Jul 25; 576:73-8.Neurosci Lett2014-05-29T00:00:002014Widespread neuron-specific transgene expression in brain and spinal cord following synapsin promoter-driven AAV9 neonatal intracerebroventricular injection.Authorship 4157476Authorship 3180731Authorship 2991903Authorship 3372045Authorship 3710514Authorship 749310624728190Smith GA, Rocha EM, McLean JR, Hayes MA, Izen SC, Isacson O, Hallett PJHuman molecular geneticsProgressive axonal transport and synaptic protein changes correlate with behavioral and neuropathological abnormalities in the heterozygous Q175 KI mouse model of Huntington's disease. Hum Mol Genet. 2014 Sep 01; 23(17):4510-27.Hum Mol Genet2014-04-12T00:00:002014Progressive axonal transport and synaptic protein changes correlate with behavioral and neuropathological abnormalities in the heterozygous Q175 KI mouse model of Huntington's disease.Authorship 534346Authorship 5617616Authorship 3557997Authorship 7641511224907400McLean JR, Smith GA, Rocha EM, Osborn TM, Dib S, Hayes MA, Beagan JA, Brown TB, Lawson TF, Hallett PJ, Robertson J, Isacson OExperimental neurologyALS-associated peripherin spliced transcripts form distinct protein inclusions that are neuroprotective against oxidative stress. Exp Neurol. 2014 Nov; 261:217-29.Exp Neurol2014-06-04T00:00:002014ALS-associated peripherin spliced transcripts form distinct protein inclusions that are neuroprotective against oxidative stress.Authorship 4450304Authorship 4473758Authorship 780794Authorship 4830466Authorship 2281004Authorship 4415251Authorship 4597734Authorship 5708533Authorship 5434901Authorship 829574Authorship 2690242Authorship 2867513Authorship 5221402Authorship 4069336Authorship 5548457Authorship 8506911Authorship 4145112Authorship 2629614Authorship 2051007Authorship 4587014Authorship 3616184Authorship 46680439Authorship 4932293Authorship 4960883Authorship 3706656Authorship 5051784Authorship 5112184Authorship 5263486Authorship 17703311Authorship 2223014Authorship 27312711Authorship 600104Authorship 4176764Authorship 769904Authorship 4690812Authorship 48589216Authorship 4886703Authorship 51200710Authorship 5567295Authorship 5534193Authorship 600472Authorship 1997442Authorship 829661Authorship 2277047Authorship 3106724Authorship 2434592Authorship 24941413Authorship 3323161Authorship 3496744Authorship 4263763Authorship 36058310Authorship 36697211Authorship 4419802Authorship 4994864Authorship 255804Authorship 2567545Authorship 5221835Authorship 4438263Authorship 2625375Authorship 950271Authorship 2829431Authorship 2947841Authorship 3555904Authorship 364815Authorship 4522732Authorship 2268953Authorship 2278015Authorship 3233573Authorship 3376786Authorship 4016061Authorship 4547727Authorship 4624775Authorship 4669737Authorship 4897483Authorship 5177505Authorship 539556Authorship 5416171Authorship 5643553Authorship 2338304Authorship 365063Authorship 3665181Authorship 3962218Authorship 4250585Authorship 5236032Authorship 5733771Authorship 79947911Authorship 8049811Authorship 78848413Authorship 7974451Authorship 798881725909088Rocha EM, Smith GA, Park E, Cao H, Brown E, Hallett P, Isacson OAnnals of clinical and translational neurologyProgressive decline of glucocerebrosidase in aging and Parkinson's disease. Ann Clin Transl Neurol. 2015 Apr; 2(4):433-8.Ann Clin Transl Neurol2015-02-06T00:00:002015Progressive decline of glucocerebrosidase in aging and Parkinson's disease.25732245Hallett PJ, Deleidi M, Astradsson A, Smith GA, Cooper O, Osborn TM, Sundberg M, Moore MA, Perez-Torres E, Brownell AL, Schumacher JM, Spealman RD, Isacson OCell stem cellSuccessful function of autologous iPSC-derived dopamine neurons following transplantation in a non-human primate model of Parkinson's disease. Cell Stem Cell. 2015 Mar 05; 16(3):269-74.Cell Stem Cell2015-02-26T00:00:002015Successful function of autologous iPSC-derived dopamine neurons following transplantation in a non-human primate model of Parkinson's disease.26007211Isacson ONature neuroscienceLysosomes to combat Parkinson's disease. Nat Neurosci. 2015 Jun; 18(6):792-3.Nat Neurosci2015-06-01T00:00:002015Lysosomes to combat Parkinson's disease.25848026Isacson OProceedings of the National Academy of Sciences of the United States of AmericaSorting the wheat from the chaff in dopamine neuron-based cell therapies. Proc Natl Acad Sci U S A. 2015 Apr 14; 112(15):4512-3.Proc Natl Acad Sci U S A2015-04-06T00:00:002015Sorting the wheat from the chaff in dopamine neuron-based cell therapies.25815475Smith GA, Rocha EM, Rooney T, Barneoud P, McLean JR, Beagan J, Osborn T, Coimbra M, Luo Y, Hallett PJ, Isacson OPloS oneA Nurr1 agonist causes neuroprotection in a Parkinson's disease lesion model primed with the toll-like receptor 3 dsRNA inflammatory stimulant poly(I:C). PLoS One. 2015; 10(3):e0121072.PLoS One2015-03-27T00:00:002015A Nurr1 agonist causes neuroprotection in a Parkinson's disease lesion model primed with the toll-like receptor 3 dsRNA inflammatory stimulant poly(I:C).Authorship 70065Authorship 2611639Authorship 3254724Authorship 3910833Authorship 4004727Authorship 4419702Authorship 4849774Authorship 4980113Authorship 5035012Authorship 5199348Authorship 5503996Authorship 4763623Authorship 3044291Authorship 3005259Authorship 316083Authorship 8260691326094487Rocha EM, Smith GA, Park E, Cao H, Graham AR, Brown E, McLean JR, Hayes MA, Beagan J, Izen SC, Perez-Torres E, Hallett PJ, Isacson OAntioxidants & redox signalingSustained Systemic Glucocerebrosidase Inhibition Induces Brain a-Synuclein Aggregation, Microglia and Complement C1q Activation in Mice. Antioxid Redox Signal. 2015 Aug 20; 23(6):550-64.Antioxid Redox Signal2015-07-29T00:00:002015Sustained Systemic Glucocerebrosidase Inhibition Induces Brain a-Synuclein Aggregation, Microglia and Complement C1q Activation in Mice.Authorship 50349411Authorship 52767611Authorship 56528413Authorship 567553Authorship 5750705Authorship 8500811Authorship 3590932Authorship 37484915Authorship 440168Authorship 4512872Authorship 4786803Authorship 4896296Authorship 8496191226392287Rocha EM, Smith GA, Park E, Cao H, Brown E, Hayes MA, Beagan J, McLean JR, Izen SC, Perez-Torres E, Hallett PJ, Isacson ONeurobiology of diseaseGlucocerebrosidase gene therapy prevents a-synucleinopathy of midbrain dopamine neurons. Neurobiol Dis. 2015 Oct; 82:495-503.Neurobiol Dis2015-09-25T00:00:002015Glucocerebrosidase gene therapy prevents a-synucleinopathy of midbrain dopamine neurons.Authorship 4645682Authorship 5210812Authorship 5325396Authorship 601412Authorship 838641Authorship 865752326839413Mazzulli JR, Zunke F, Isacson O, Studer L, Krainc DProceedings of the National Academy of Sciences of the United States of Americaa-Synuclein-induced lysosomal dysfunction occurs through disruptions in protein trafficking in human midbrain synucleinopathy models. Proc Natl Acad Sci U S A. 2016 Feb 16; 113(7):1931-6.Proc Natl Acad Sci U S A2016-02-02T00:00:002016a-Synuclein-induced lysosomal dysfunction occurs through disruptions in protein trafficking in human midbrain synucleinopathy models.Authorship 3810895Authorship 3886993Authorship 877845426944602Jeon J, Kim W, Jang J, Isacson O, Seo HNeuroscienceGene therapy by proteasome activator, PA28?, improves motor coordination and proteasome function in Huntington's disease YAC128 mice. Neuroscience. 2016 Jun 02; 324:20-8.Neuroscience2016-03-02T00:00:002016Gene therapy by proteasome activator, PA28?, improves motor coordination and proteasome function in Huntington's disease YAC128 mice.Authorship 4689832Authorship 5098595Authorship 881782326691153Korecka JA, Levy S, Isacson OMolecular and cellular neurosciencesIn vivo modeling of neuronal function, axonal impairment and connectivity in neurodegenerative and neuropsychiatric disorders using induced pluripotent stem cells. Mol Cell Neurosci. 2016 06; 73:3-12.Mol Cell Neurosci2015-12-10T00:00:002015In vivo modeling of neuronal function, axonal impairment and connectivity in neurodegenerative and neuropsychiatric disorders using induced pluripotent stem cells.Authorship 5546072Assistant Professor1Associate Professor0Full Professor4Instructor3LecturerAuthorship 9284Authorship 4858102Authorship 598796Authorship 894900827137201Xiong N, Li N, Martin E, Yu J, Li J, Liu J, Lee DY, Isacson O, Vance J, Qing H, Wang T, Lin ZNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeuticshVMAT2: A Target of Individualized Medication for Parkinson's Disease. Neurotherapeutics. 2016 07; 13(3):623-34.Neurotherapeutics2016-07-01T00:00:002016hVMAT2: A Target of Individualized Medication for Parkinson's Disease.Authorship 4919431Authorship 5336173Authorship 5438406Authorship 676342Authorship 4774057Authorship 4974785Authorship 5415837Authorship 567763Authorship 912868626399642Smith GA, Jansson J, Rocha EM, Osborn T, Hallett PJ, Isacson OMolecular neurobiologyFibroblast Biomarkers of Sporadic Parkinson's Disease and LRRK2 Kinase Inhibition. Mol Neurobiol. 2016 10; 53(8):5161-77.Mol Neurobiol2015-09-23T00:00:002015Fibroblast Biomarkers of Sporadic Parkinson's Disease and LRRK2 Kinase Inhibition.Authorship 719972Authorship 3754442Authorship 3843747Authorship 4387302Authorship 4598731Authorship 5591846Authorship 938292227894611Engelender S, Isacson OTrends in neurosciencesThe Threshold Theory for Parkinson's Disease. Trends Neurosci. 2017 01; 40(1):4-14.Trends Neurosci2016-11-25T00:00:002016The Threshold Theory for Parkinson's Disease.Authorship 2590661Authorship 3529874Authorship 3785783Authorship 3945583Authorship 943247427418401Kordower JH, Vinuela A, Chu Y, Isacson O, Redmond DEThe Journal of comparative neurologyParkinsonian monkeys with prior levodopa-induced dyskinesias followed by fetal dopamine precursor grafts do not display graft-induced dyskinesias. J Comp Neurol. 2017 02 15; 525(3):498-512.J Comp Neurol2016-08-29T00:00:002016Parkinsonian monkeys with prior levodopa-induced dyskinesias followed by fetal dopamine precursor grafts do not display graft-induced dyskinesias.Authorship 4259898Authorship 4629855Authorship 470843Authorship 485909Authorship 4908391Authorship 5331852Authorship 5769451Authorship 956516128148380Isacson O, Kordower JHCell transplantationTHE NEUROBIOLOGICAL AND CLINICAL POTENTIAL OF NEURAL CELL TRANSPLANTATION: SPECIAL ISSUE BASED ON THE MEETING OF THE AMERICAN SOCIETY FOR NEURAL TRANSPLANTATION, 1995. Cell Transplant. 1996 Mar 01; 5(2):123-125.Cell Transplant1996-03-01T00:00:001996THE NEUROBIOLOGICAL AND CLINICAL POTENTIAL OF NEURAL CELL TRANSPLANTATION: SPECIAL ISSUE BASED ON THE MEETING OF THE AMERICAN SOCIETY FOR NEURAL TRANSPLANTATION, 1995.Authorship 738519243621Costantini LC, Lin L, Isacson ONeuroreportMedial fetal ventral mesencephalon: a preferred source for dopamine neuron grafts. Neuroreport. 1997 Jul 07; 8(9-10):2253-7.Neuroreport1997-07-07T00:00:001997Medial fetal ventral mesencephalon: a preferred source for dopamine neuron grafts.9809556Brownell AL, Jenkins BG, Elmaleh DR, Deacon TW, Spealman RD, Isacson ONature medicineCombined PET/MRS brain studies show dynamic and long-term physiological changes in a primate model of Parkinson disease. Nat Med. 1998 Nov; 4(11):1308-12.Nat Med1998-11-01T00:00:001998Combined PET/MRS brain studies show dynamic and long-term physiological changes in a primate model of Parkinson disease.1521320Beal MF, Swartz KJ, Isacson OBrain research. Developmental brain researchDevelopmental changes in brain kynurenic acid concentrations. Brain Res Dev Brain Res. 1992 Jul 24; 68(1):136-9.Brain Res Dev Brain Res1992-07-24T00:00:001992Developmental changes in brain kynurenic acid concentrations.12429184Cicchetti F, Costantini L, Belizaire R, Burton W, Isacson O, Fodor WExperimental neurologyCombined inhibition of apoptosis and complement improves neural graft survival of embryonic rat and porcine mesencephalon in the rat brain. Exp Neurol. 2002 Oct; 177(2):376-84.Exp Neurol2002-10-01T00:00:002002Combined inhibition of apoptosis and complement improves neural graft survival of embryonic rat and porcine mesencephalon in the rat brain.12657457Hunter CL, Isacson O, Nelson M, Bimonte-Nelson H, Seo H, Lin L, Ford K, Kindy MS, Granholm ACNeuroscience researchRegional alterations in amyloid precursor protein and nerve growth factor across age in a mouse model of Down's syndrome. Neurosci Res. 2003 Apr; 45(4):437-45.Neurosci Res2003-04-01T00:00:002003Regional alterations in amyloid precursor protein and nerve growth factor across age in a mouse model of Down's syndrome.16123386Kim DW, Chung S, Hwang M, Ferree A, Tsai HC, Park JJ, Chung S, Nam TS, Kang UJ, Isacson O, Kim KSStem cells (Dayton, Ohio)Stromal cell-derived inducing activity, Nurr1, and signaling molecules synergistically induce dopaminergic neurons from mouse embryonic stem cells. Stem Cells. 2006 Mar; 24(3):557-67.Stem Cells2005-08-25T00:00:002005Stromal cell-derived inducing activity, Nurr1, and signaling molecules synergistically induce dopaminergic neurons from mouse embryonic stem cells.1515582Hantraye P, Brownell AL, Elmaleh D, Spealman RD, Wüllner U, Brownell GL, Madras BK, Isacson ONeuroreportDopamine fiber detection by [11C]-CFT and PET in a primate model of parkinsonism. Neuroreport. 1992 Mar; 3(3):265-8.Neuroreport1992-03-01T00:00:001992Dopamine fiber detection by [11C]-CFT and PET in a primate model of parkinsonism.15737733Sonntag KC, Simantov R, Björklund L, Cooper O, Pruszak J, Kowalke F, Gilmartin J, Ding J, Hu YP, Shen MM, Isacson OMolecular and cellular neurosciencesContext-dependent neuronal differentiation and germ layer induction of Smad4-/- and Cripto-/- embryonic stem cells. Mol Cell Neurosci. 2005 Mar; 28(3):417-29.Mol Cell Neurosci2005-03-01T00:00:002005Context-dependent neuronal differentiation and germ layer induction of Smad4-/- and Cripto-/- embryonic stem cells.15790528Sonntag KC, Simantov R, Isacson OBrain research. Molecular brain researchStem cells may reshape the prospect of Parkinson's disease therapy. Brain Res Mol Brain Res. 2005 Mar 24; 134(1):34-51.Brain Res Mol Brain Res2005-03-24T00:00:002005Stem cells may reshape the prospect of Parkinson's disease therapy.1337940Rosenberg WS, Breakefield XO, DeAntonio C, Isacson OBrain research. Molecular brain researchAuthentic and artifactual detection of the E. coli lacZ gene product in the rat brain by histochemical methods. Brain Res Mol Brain Res. 1992 Dec; 16(3-4):311-5.Brain Res Mol Brain Res1992-12-01T00:00:001992Authentic and artifactual detection of the E. coli lacZ gene product in the rat brain by histochemical methods.Authorship 9652451027021023Wang X, Li N, Xiong N, You Q, Li J, Yu J, Qing H, Wang T, Cordell HJ, Isacson O, Vance JM, Martin ER, Zhao Y, Cohen BM, Buttner EA, Lin ZMolecular neurobiologyGenetic Variants of Microtubule Actin Cross-linking Factor 1 (MACF1) Confer Risk for Parkinson's Disease. Mol Neurobiol. 2017 05; 54(4):2878-2888.Mol Neurobiol2016-03-28T00:00:002016Genetic Variants of Microtubule Actin Cross-linking Factor 1 (MACF1) Confer Risk for Parkinson's Disease.9288721Isacson O, Breakefield XONature medicineBenefits and risks of hosting animal cells in the human brain. Nat Med. 1997 Sep; 3(9):964-9.Nat Med1997-09-01T00:00:001997Benefits and risks of hosting animal cells in the human brain.10486171Kordower JH, Isacson O, Emerich DFExperimental neurologyCellular delivery of trophic factors for the treatment of Huntington's disease: is neuroprotection possible? Exp Neurol. 1999 Sep; 159(1):4-20.Exp Neurol1999-09-01T00:00:001999Cellular delivery of trophic factors for the treatment of Huntington's disease: is neuroprotection possible?8981438Galpern WR, Matthews RT, Beal MF, Isacson ONeuroreportNGF attenuates 3-nitrotyrosine formation in a 3-NP model of Huntington's disease. Neuroreport. 1996 Nov 04; 7(15-17):2639-42.Neuroreport1996-11-04T00:00:001996NGF attenuates 3-nitrotyrosine formation in a 3-NP model of Huntington's disease.9506557Brownell AL, Livni E, Galpern W, Isacson OAnnals of neurologyIn vivo PET imaging in rat of dopamine terminals reveals functional neural transplants. Ann Neurol. 1998 Mar; 43(3):387-90.Ann Neurol1998-03-01T00:00:001998In vivo PET imaging in rat of dopamine terminals reveals functional neural transplants.10192773Boonman Z, Isacson OExperimental neurologyApoptosis in neuronal development and transplantation: role of caspases and trophic factors. Exp Neurol. 1999 Mar; 156(1):1-15.Exp Neurol1999-03-01T00:00:001999Apoptosis in neuronal development and transplantation: role of caspases and trophic factors.19711122Cooper O, Astradsson A, Hallett P, Robertson H, Mendez I, Isacson OJournal of neurologyLack of functional relevance of isolated cell damage in transplants of Parkinson's disease patients. J Neurol. 2009 Aug; 256 Suppl 3:310-6.J Neurol2009-08-01T00:00:002009Lack of functional relevance of isolated cell damage in transplants of Parkinson's disease patients.19960452Pruszak J, Just L, Isacson O, Nikkhah GCurrent protocols in stem cell biologyIsolation and culture of ventral mesencephalic precursor cells and dopaminergic neurons from rodent brains. Curr Protoc Stem Cell Biol. 2009 Dec; Chapter 2:Unit 2D.5.Curr Protoc Stem Cell Biol2009-12-01T00:00:002009Isolation and culture of ventral mesencephalic precursor cells and dopaminergic neurons from rodent brains.11948255Seo H, Hong SJ, Guo S, Kim HS, Kim CH, Hwang DY, Isacson O, Rosenthal A, Kim KSJournal of neurochemistryA direct role of the homeodomain proteins Phox2a/2b in noradrenaline neurotransmitter identity determination. J Neurochem. 2002 Mar; 80(5):905-16.J Neurochem2002-03-01T00:00:002002A direct role of the homeodomain proteins Phox2a/2b in noradrenaline neurotransmitter identity determination.1810624Levisohn LF, Isacson OBrain researchExcitotoxic lesions of the rat entorhinal cortex. Effects of selective neuronal damage on acquisition and retention of a non-spatial reference memory task. Brain Res. 1991 Nov 15; 564(2):230-44.Brain Res1991-11-15T00:00:001991Excitotoxic lesions of the rat entorhinal cortex. Effects of selective neuronal damage on acquisition and retention of a non-spatial reference memory task.15737744Lin L, Rao Y, Isacson OMolecular and cellular neurosciencesNetrin-1 and slit-2 regulate and direct neurite growth of ventral midbrain dopaminergic neurons. Mol Cell Neurosci. 2005 Mar; 28(3):547-55.Mol Cell Neurosci2005-03-01T00:00:002005Netrin-1 and slit-2 regulate and direct neurite growth of ventral midbrain dopaminergic neurons.15888489Chung CY, Seo H, Sonntag KC, Brooks A, Lin L, Isacson OHuman molecular geneticsCell type-specific gene expression of midbrain dopaminergic neurons reveals molecules involved in their vulnerability and protection. Hum Mol Genet. 2005 Jul 01; 14(13):1709-25.Hum Mol Genet2005-05-11T00:00:002005Cell type-specific gene expression of midbrain dopaminergic neurons reveals molecules involved in their vulnerability and protection.9126163Haque N, Isacson OExperimental neurologyAntisense gene therapy for neurodegenerative disease? Exp Neurol. 1997 Mar; 144(1):139-46.Exp Neurol1997-03-01T00:00:001997Antisense gene therapy for neurodegenerative disease?11142039Kordower JH, Isacson O, Leventhal L, Emerich DFProgress in brain researchCellular delivery of trophic factors for the treatment of Huntington's disease: is neuroprotection possible? Prog Brain Res. 2000; 127:414-30.Prog Brain Res2000-01-01T00:00:002000Cellular delivery of trophic factors for the treatment of Huntington's disease: is neuroprotection possible?11377843Holm KH, Cicchetti F, Bjorklund L, Boonman Z, Tandon P, Costantini LC, Deacon TW, Huang X, Chen DF, Isacson ONeuroscienceEnhanced axonal growth from fetal human bcl-2 transgenic mouse dopamine neurons transplanted to the adult rat striatum. 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