Immunoglobulin Light Chains, Surrogate
"Immunoglobulin Light Chains, Surrogate" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An immunolglobulin light chain-like protein composed of an IMMUNOGLOBULIN VARIABLE REGION-like peptide (such as light chain like lambda5 peptide) and an IMMUNOGLOBULIN CONSTANT REGION-like peptide (such as Vpreb1 peptide). Surrogate light chains associate with MU IMMUNOGLOBULIN HEAVY CHAINS in place of a conventional immunoglobulin light chains to form pre-B cell receptors.
MeSH Number(s)
D12.776.124.486.485.705.750.775
D12.776.124.486.485.950.750.500
D12.776.124.790.651.705.750.775
D12.776.124.790.651.950.750.500
D12.776.377.715.548.705.750.775
D12.776.377.715.548.950.750.500
D12.776.543.750.705.816.821.750.500
Concept/Terms
Immunoglobulin Light Chains, Surrogate- Immunoglobulin Light Chains, Surrogate
- psiL Chain, Immunoglobulin
- Immunoglobulin psiL Chain
- Surrogate Light Chains
- Light Chains, Surrogate
- Surrogate L Chain Protein
- Surrogate Light Chain
- Light Chain, Surrogate
- Pseudo Immunoglobulin Light Chain
- Surrogate Immunoglobulin Light Chains
Surrogate lambda Light Chain- Surrogate lambda Light Chain
- VpreB-lambda 5 SL Chain
- VpreB lambda 5 SL Chain
- VpreB-lambda5 Surrogate Light Chain
- VpreB lambda5 Surrogate Light Chain
- psi lambda Light Chain
Below are MeSH descriptors whose meaning is more general than "Immunoglobulin Light Chains, Surrogate".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Blood Proteins [D12.776.124]
- Immunoproteins [D12.776.124.486]
- Immunoglobulins [D12.776.124.486.485]
- Immunoglobulin Subunits [D12.776.124.486.485.705]
- Immunoglobulin Light Chains [D12.776.124.486.485.705.750]
- Immunoglobulin Light Chains, Surrogate [D12.776.124.486.485.705.750.775]
- Receptors, Antigen, B-Cell [D12.776.124.486.485.950]
- Pre-B Cell Receptors [D12.776.124.486.485.950.750]
- Immunoglobulin Light Chains, Surrogate [D12.776.124.486.485.950.750.500]
- Serum Globulins [D12.776.124.790]
- Immunoglobulins [D12.776.124.790.651]
- Immunoglobulin Subunits [D12.776.124.790.651.705]
- Immunoglobulin Light Chains [D12.776.124.790.651.705.750]
- Immunoglobulin Light Chains, Surrogate [D12.776.124.790.651.705.750.775]
- Receptors, Antigen, B-Cell [D12.776.124.790.651.950]
- Pre-B Cell Receptors [D12.776.124.790.651.950.750]
- Immunoglobulin Light Chains, Surrogate [D12.776.124.790.651.950.750.500]
- Globulins [D12.776.377]
- Serum Globulins [D12.776.377.715]
- Immunoglobulins [D12.776.377.715.548]
- Immunoglobulin Subunits [D12.776.377.715.548.705]
- Immunoglobulin Light Chains [D12.776.377.715.548.705.750]
- Immunoglobulin Light Chains, Surrogate [D12.776.377.715.548.705.750.775]
- Receptors, Antigen, B-Cell [D12.776.377.715.548.950]
- Pre-B Cell Receptors [D12.776.377.715.548.950.750]
- Immunoglobulin Light Chains, Surrogate [D12.776.377.715.548.950.750.500]
- Membrane Proteins [D12.776.543]
- Receptors, Cell Surface [D12.776.543.750]
- Receptors, Immunologic [D12.776.543.750.705]
- Receptors, Antigen [D12.776.543.750.705.816]
- Receptors, Antigen, B-Cell [D12.776.543.750.705.816.821]
- Pre-B Cell Receptors [D12.776.543.750.705.816.821.750]
- Immunoglobulin Light Chains, Surrogate [D12.776.543.750.705.816.821.750.500]
Below are MeSH descriptors whose meaning is more specific than "Immunoglobulin Light Chains, Surrogate".
This graph shows the total number of publications written about "Immunoglobulin Light Chains, Surrogate" by people in Harvard Catalyst Profiles by year, and whether "Immunoglobulin Light Chains, Surrogate" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
---|
1994 | 0 | 1 | 1 |
2007 | 0 | 1 | 1 |
2013 | 1 | 0 | 1 |
2015 | 0 | 1 | 1 |
Below are the most recent publications written about "Immunoglobulin Light Chains, Surrogate" by people in Profiles.
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Genomics and drug profiling of fatal TCF3-HLF-positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options. Nat Genet. 2015 Sep; 47(9):1020-1029.
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VPREB1 deletions occur independent of lambda light chain rearrangement in childhood acute lymphoblastic leukemia. Leukemia. 2014 Jan; 28(1):216-20.
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Pillars article: a critical role of lambda 5 protein in B cell development. Cell. 1992. 69: 823-831. J Immunol. 2010 Feb 01; 184(3):1130-8.
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A unique role for the lambda5 nonimmunoglobulin tail in early B lymphocyte development. J Immunol. 2008 Sep 01; 181(5):3232-42.
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Engineering and characterization of a single chain surrogate light chain variable domain. Protein Sci. 2008 Mar; 17(3):458-65.
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Structural insight into pre-B cell receptor function. Science. 2007 Apr 13; 316(5822):291-4.
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Ikaros DNA-binding proteins as integral components of B cell developmental-stage-specific regulatory circuits. Immunity. 2007 Mar; 26(3):335-44.
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A prematurely expressed Ig(kappa) transgene, but not V(kappa)J(kappa) gene segment targeted into the Ig(kappa) locus, can rescue B cell development in lambda5-deficient mice. Immunity. 1996 Sep; 5(3):229-39.
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Surrogate light chain expression is required to establish immunoglobulin heavy chain allelic exclusion during early B cell development. Immunity. 1996 Feb; 4(2):133-44.
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The expression of Vpre-B/lambda 5 surrogate light chain in early bone marrow precursor B cells of normal and B cell-deficient mutant mice. Cell. 1994 Apr 08; 77(1):133-43.