Variant Surface Glycoproteins, Trypanosoma
"Variant Surface Glycoproteins, Trypanosoma" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Glycoproteins attached to the surface coat of the trypanosome. Many of these glycoproteins show amino acid sequence diversity expressed as antigenic variations. This continuous development of antigenically distinct variants in the course of infection ensures that some trypanosomes always survive the development of immune response to propagate the infection.
MeSH Number(s)
D12.776.395.550.990
D12.776.543.550.990
D23.050.293.900
D23.050.301.900
Below are MeSH descriptors whose meaning is more general than "Variant Surface Glycoproteins, Trypanosoma".
Below are MeSH descriptors whose meaning is more specific than "Variant Surface Glycoproteins, Trypanosoma".
This graph shows the total number of publications written about "Variant Surface Glycoproteins, Trypanosoma" by people in Harvard Catalyst Profiles by year, and whether "Variant Surface Glycoproteins, Trypanosoma" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1995 | 1 | 0 | 1 |
1996 | 1 | 0 | 1 |
1999 | 0 | 1 | 1 |
2009 | 0 | 1 | 1 |
2014 | 1 | 0 | 1 |
2018 | 1 | 0 | 1 |
Below are the most recent publications written about "Variant Surface Glycoproteins, Trypanosoma" by people in Profiles.
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African trypanosomes evade immune clearance by O-glycosylation of the VSG surface coat. Nat Microbiol. 2018 08; 3(8):932-938.
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Trypanosoma brucei RAP1 maintains telomere and subtelomere integrity by suppressing TERRA and telomeric RNA:DNA hybrids. Nucleic Acids Res. 2017 Jun 02; 45(10):5785-5796.
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Identification of sVSG117 as an immunodiagnostic antigen and evaluation of a dual-antigen lateral flow test for the diagnosis of human African trypanosomiasis. PLoS Negl Trop Dis. 2014 Jul; 8(7):e2976.
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Silencing subtelomeric VSGs by Trypanosoma brucei RAP1 at the insect stage involves chromatin structure changes. Nucleic Acids Res. 2013 Sep; 41(16):7673-82.
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T. brucei infection reduces B lymphopoiesis in bone marrow and truncates compensatory splenic lymphopoiesis through transitional B-cell apoptosis. PLoS Pathog. 2011 Jun; 7(6):e1002089.
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A yeast-endonuclease-generated DNA break induces antigenic switching in Trypanosoma brucei. Nature. 2009 May 14; 459(7244):278-81.
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The binding of CCL2 to the surface of Trypanosoma cruzi induces chemo-attraction and morphogenesis. Microbes Infect. 2007 Jan; 9(1):111-8.
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The potency and durability of DNA- and protein-based vaccines against Leishmania major evaluated using low-dose, intradermal challenge. J Immunol. 2001 Apr 15; 166(8):5122-8.
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CD1d-restricted immunoglobulin G formation to GPI-anchored antigens mediated by NKT cells. Science. 1999 Jan 08; 283(5399):225-9.
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Characterization of a small variable surface glycoprotein from Trypanosoma vivax. Mol Biochem Parasitol. 1996 Nov 12; 82(1):1-11.