PHEX Phosphate Regulating Neutral Endopeptidase
"PHEX Phosphate Regulating Neutral Endopeptidase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A membrane-bound metalloendopeptidase that may play a role in the degradation or activation of a variety of PEPTIDE HORMONES and INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS. Genetic mutations that result in loss of function of this protein are a cause of HYPOPHOSPHATEMIC RICKETS, X-LINKED DOMINANT.
MeSH Number(s)
D08.811.277.656.300.480.616
D08.811.277.656.675.374.616
D12.776.395.550.611
D12.776.543.550.607
Concept/Terms
PHEX Phosphate Regulating Neutral Endopeptidase- PHEX Phosphate Regulating Neutral Endopeptidase
- X-Linked Phosphate Regulating Endopeptidase Homolog
- X Linked Phosphate Regulating Endopeptidase Homolog
- Phosphate Regulating Neutral Endopeptidase
- PEX Phosphate Regulating Neutral Endopeptidase
- Phosphate Regulating Endopeptidase Homolog, X-Linked
- Phosphate Regulating Endopeptidase Homolog, X Linked
Below are MeSH descriptors whose meaning is more general than "PHEX Phosphate Regulating Neutral Endopeptidase".
Below are MeSH descriptors whose meaning is more specific than "PHEX Phosphate Regulating Neutral Endopeptidase".
This graph shows the total number of publications written about "PHEX Phosphate Regulating Neutral Endopeptidase" by people in Harvard Catalyst Profiles by year, and whether "PHEX Phosphate Regulating Neutral Endopeptidase" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1997 | 0 | 1 | 1 |
1998 | 0 | 1 | 1 |
2001 | 0 | 3 | 3 |
2004 | 0 | 1 | 1 |
2005 | 0 | 2 | 2 |
2006 | 0 | 1 | 1 |
2009 | 0 | 1 | 1 |
2015 | 1 | 0 | 1 |
2021 | 0 | 2 | 2 |
2022 | 0 | 1 | 1 |
2023 | 0 | 1 | 1 |
Below are the most recent publications written about "PHEX Phosphate Regulating Neutral Endopeptidase" by people in Profiles.
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X-linked hypophosphatemia in 4 generations due to an exon 13-15 duplication in PHEX, in the absence of the c.*231A>G variant. Bone. 2023 07; 172:116763.
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Genetic and clinical profile of patients with hypophosphatemic rickets. Eur J Med Genet. 2022 Aug; 65(8):104540.
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Conductive Hearing Loss in the Hyp Mouse Model of X-Linked Hypophosphatemia Is Accompanied by Hypomineralization of the Auditory Ossicles. J Bone Miner Res. 2021 12; 36(12):2317-2328.
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Osteocytes but not osteoblasts directly build mineralized bone structures. Int J Biol Sci. 2021; 17(10):2430-2448.
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Whole Exome Sequencing Reveals Novel PHEX Splice Site Mutations in Patients with Hypophosphatemic Rickets. PLoS One. 2015; 10(6):e0130729.
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Regulation of FGF23 expression in IDG-SW3 osteocytes and human bone by pro-inflammatory stimuli. Mol Cell Endocrinol. 2015 Jan 05; 399:208-18.
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Calcium induces pro-anabolic effects on human primary osteoblasts associated with acquisition of mature osteocyte markers. Mol Cell Endocrinol. 2013 Aug 25; 376(1-2):85-92.
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FGF23-induced hypophosphatemia persists in Hyp mice deficient in the WNT coreceptor Lrp6. Contrib Nephrol. 2013; 180:124-37.
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Proteolytic processing of osteopontin by PHEX and accumulation of osteopontin fragments in Hyp mouse bone, the murine model of X-linked hypophosphatemia. J Bone Miner Res. 2013 Mar; 28(3):688-99.
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Sclerostin is a locally acting regulator of late-osteoblast/preosteocyte differentiation and regulates mineralization through a MEPE-ASARM-dependent mechanism. J Bone Miner Res. 2011 Jul; 26(7):1425-36.