Gene Products, nef

"Gene Products, nef" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Products of the retroviral NEF GENE. They play a role as accessory proteins that influence the rate of viral infectivity and the destruction of the host immune system. nef gene products were originally found as factors that trans-suppress viral replication and function as negative regulators of transcription. nef stands for negative factor.

Descriptor ID

D015693

MeSH Number(s)

D12.776.964.775.362

D12.776.964.925.500

Concept/Terms

Gene Products, nef

Below are MeSH descriptors whose meaning is more general than "Gene Products, nef".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Viral Proteins [D12.776.964]
Retroviridae Proteins [D12.776.964.775]
Gene Products, nef [D12.776.964.775.362]
Viral Regulatory and Accessory Proteins [D12.776.964.925]
Gene Products, nef [D12.776.964.925.500]

Below are MeSH descriptors whose meaning is related to "Gene Products, nef".

Below are MeSH descriptors whose meaning is more specific than "Gene Products, nef".

Gene Products, nef
nef Gene Products, Human Immunodeficiency Virus

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Gene Products, nef" by people in Harvard Catalyst Profiles by year, and whether "Gene Products, nef" was a major or minor topic of these publication.

Bar chart showing 75 publications over 23 distinct years, with a maximum of 12 publications in 2000

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	0	1	1
1995	0	2	2
1996	0	1	1
1997	2	2	4
1998	4	1	5
1999	6	1	7
2000	4	8	12
2001	1	2	3
2002	2	3	5
2003	1	4	5
2004	1	2	3
2005	1	3	4
2006	3	3	6
2007	3	0	3
2008	1	2	3
2009	1	0	1
2010	1	0	1
2011	0	2	2
2012	0	1	1
2014	0	1	1
2018	1	0	1
2019	2	0	2
2020	0	2	2

Below are the most recent publications written about "Gene Products, nef" by people in Profiles.

Loss of tetherin antagonism by Nef impairs SIV replication during acute infection of rhesus macaques. PLoS Pathog. 2020 04; 16(4):e1008487.

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Mannose receptor is an HIV restriction factor counteracted by Vpr in macrophages. Elife. 2020 03 02; 9.

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EMAPII: A Key Player in HIV-Nef-induced Pulmonary Vasculopathy. Am J Respir Cell Mol Biol. 2019 Mar; 60(3):257-258.

View in: PubMed
The Frequency of Vaccine-Induced T-Cell Responses Does Not Predict the Rate of Acquisition after Repeated Intrarectal SIVmac239 Challenges in Mamu-B*08+ Rhesus Macaques. J Virol. 2019 03 01; 93(5).

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Mamu-B*17+ Rhesus Macaques Vaccinated with env, vif, and nef Manifest Early Control of SIVmac239 Replication. J Virol. 2018 08 15; 92(16).

View in: PubMed
Multimodality vaccination against clade C SHIV: partial protection against mucosal challenges with a heterologous tier 2 virus. Vaccine. 2014 Nov 12; 32(48):6527-36.

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A trivalent recombinant Ad5 gag/pol/nef vaccine fails to protect rhesus macaques from infection or control virus replication after a limiting-dose heterologous SIV challenge. Vaccine. 2012 Jun 22; 30(30):4465-75.

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Vaccine protection against simian immunodeficiency virus in monkeys using recombinant gamma-2 herpesvirus. J Virol. 2011 Dec; 85(23):12708-20.

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Limited immunogenicity of HIV CD8+ T-cell epitopes in acute Clade C virus infection. J Infect Dis. 2011 Sep 01; 204(5):768-76.

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Mutations in a dominant Nef epitope of simian immunodeficiency virus diminish TCR:epitope peptide affinity but not epitope peptide:MHC class I binding. J Immunol. 2011 Sep 15; 187(6):3300-13.

View in: PubMed

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