Phosphatidylinositol 4,5-Diphosphate
"Phosphatidylinositol 4,5-Diphosphate" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A phosphoinositide present in all eukaryotic cells, particularly in the plasma membrane. It is the major substrate for receptor-stimulated phosphoinositidase C, with the consequent formation of inositol 1,4,5-triphosphate and diacylglycerol, and probably also for receptor-stimulated inositol phospholipid 3-kinase. (Kendrew, The Encyclopedia of Molecular Biology, 1994)
MeSH Number(s)
D10.570.755.375.760.400.942.625.900
Concept/Terms
Phosphatidylinositol 4,5-Diphosphate- Phosphatidylinositol 4,5-Diphosphate
- 4,5-Diphosphate, Phosphatidylinositol
- Phosphatidylinositol 4,5 Diphosphate
- Phosphatidylinositol Phosphate, PtdIns(4,5)P2
- PtIns 4,5-P2
- PtdIns(4,5)P2
- PtdInsP
- PtdInsP2
- Phosphatidylinositol 4,5-Biphosphate
- 4,5-Biphosphate, Phosphatidylinositol
- Phosphatidylinositol 4,5 Biphosphate
- Phosphatidylinositol-4,5-Biphosphate
Below are MeSH descriptors whose meaning is more general than "Phosphatidylinositol 4,5-Diphosphate".
Below are MeSH descriptors whose meaning is more specific than "Phosphatidylinositol 4,5-Diphosphate".
This graph shows the total number of publications written about "Phosphatidylinositol 4,5-Diphosphate" by people in Harvard Catalyst Profiles by year, and whether "Phosphatidylinositol 4,5-Diphosphate" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 2 | 2 |
| 1995 | 0 | 2 | 2 |
| 1996 | 1 | 3 | 4 |
| 1997 | 2 | 2 | 4 |
| 1998 | 2 | 1 | 3 |
| 1999 | 0 | 5 | 5 |
| 2000 | 4 | 2 | 6 |
| 2001 | 4 | 2 | 6 |
| 2002 | 2 | 1 | 3 |
| 2003 | 1 | 2 | 3 |
| 2004 | 0 | 2 | 2 |
| 2005 | 3 | 2 | 5 |
| 2006 | 2 | 2 | 4 |
| 2007 | 0 | 1 | 1 |
| 2008 | 1 | 2 | 3 |
| 2009 | 0 | 2 | 2 |
| 2010 | 2 | 0 | 2 |
| 2012 | 3 | 2 | 5 |
| 2013 | 1 | 2 | 3 |
| 2014 | 2 | 2 | 4 |
| 2015 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
| 2017 | 1 | 3 | 4 |
| 2018 | 2 | 0 | 2 |
| 2019 | 3 | 1 | 4 |
| 2020 | 0 | 1 | 1 |
| 2021 | 2 | 1 | 3 |
| 2022 | 0 | 1 | 1 |
| 2023 | 1 | 1 | 2 |
Below are the most recent publications written about "Phosphatidylinositol 4,5-Diphosphate" by people in Profiles.
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Inhibition of the proton-activated chloride channel PAC by PIP2. Elife. 2023 01 12; 12.
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PI(4,5)P2 and Cholesterol: Synthesis, Regulation, and Functions. Adv Exp Med Biol. 2023; 1422:3-59.
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Septins tune lipid kinase activity and PI(4,5)P2 turnover during G-protein-coupled PLC signalling in vivo. Life Sci Alliance. 2022 06; 5(6).
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Closed-state inactivation and pore-blocker modulation mechanisms of human CaV2.2. Cell Rep. 2021 11 02; 37(5):109931.
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PIP2 regulation of TRPC5 channel activation and desensitization. J Biol Chem. 2021 Jan-Jun; 296:100726.
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ß-arrestin-dependent PI(4,5)P2 synthesis boosts GPCR endocytosis. Proc Natl Acad Sci U S A. 2021 04 27; 118(17).
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Alt-RPL36 downregulates the PI3K-AKT-mTOR signaling pathway by interacting with TMEM24. Nat Commun. 2021 01 21; 12(1):508.
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Paladin is a phosphoinositide phosphatase regulating endosomal VEGFR2 signalling and angiogenesis. EMBO Rep. 2021 02 03; 22(2):e50218.
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a-Synuclein facilitates endocytosis by elevating the steady-state levels of phosphatidylinositol 4,5-bisphosphate. J Biol Chem. 2020 12 25; 295(52):18076-18090.
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The small molecule GAT1508 activates brain-specific GIRK1/2 channel heteromers and facilitates conditioned fear extinction in rodents. J Biol Chem. 2020 03 13; 295(11):3614-3634.