Chromosomal Position Effects

"Chromosomal Position Effects" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The effects on gene expression that depend on the location of a gene with respect to its neighboring genes and region of chromosome. Stable position effects are sequence dependent. Variegated position effects depend on whether the gene is located in or adjacent to HETEROCHROMATIN or EUCHROMATIN.

Descriptor ID

D055012

MeSH Number(s)

G05.355.315.203.124

Concept/Terms

Chromosomal Position Effects

Position Effect Variegation

Below are MeSH descriptors whose meaning is more general than "Chromosomal Position Effects".

Biological Sciences [G]
Genetic Phenomena [G05]
Genetic Processes [G05.355]
Gene Expression Regulation [G05.355.315]
Epigenesis, Genetic [G05.355.315.203]
Chromosomal Position Effects [G05.355.315.203.124]

Below are MeSH descriptors whose meaning is related to "Chromosomal Position Effects".

Below are MeSH descriptors whose meaning is more specific than "Chromosomal Position Effects".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Chromosomal Position Effects" by people in Harvard Catalyst Profiles by year, and whether "Chromosomal Position Effects" was a major or minor topic of these publication.

Bar chart showing 5 publications over 3 distinct years, with a maximum of 2 publications in 2017 and 2018

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2008	0	1	1
2017	2	0	2
2018	2	0	2

Below are the most recent publications written about "Chromosomal Position Effects" by people in Profiles.

Computational Prediction of Position Effects of Human Chromosome Rearrangements. Curr Protoc Hum Genet. 2018 04; 97(1):e57.

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Phenotypic interpretation of complex chromosomal rearrangements informed by nucleotide-level resolution and structural organization of chromatin. Eur J Hum Genet. 2018 03; 26(3):374-381.

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Replication stress affects the fidelity of nucleosome-mediated epigenetic inheritance. PLoS Genet. 2017 Jul; 13(7):e1006900.

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Computational Prediction of Position Effects of Apparently Balanced Human Chromosomal Rearrangements. Am J Hum Genet. 2017 Aug 03; 101(2):206-217.

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upSET, the Drosophila homologue of SET3, Is Required for Viability and the Proper Balance of Active and Repressive Chromatin Marks. G3 (Bethesda). 2017 02 09; 7(2):625-635.

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Position-effect variegation revisited: HUSHing up heterochromatin in human cells. Bioessays. 2016 Apr; 38(4):333-43.

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GENE SILENCING. Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells. Science. 2015 Jun 26; 348(6242):1481-1485.

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Targeted transgene integration overcomes variability of position effects in zebrafish. Development. 2014 Feb; 141(3):715-24.

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A distinct type of heterochromatin at the telomeric region of the Drosophila melanogaster Y chromosome. PLoS One. 2014; 9(1):e86451.

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Chromosomal context and epigenetic mechanisms control the efficacy of genome editing by rare-cutting designer endonucleases. Nucleic Acids Res. 2012 Jul; 40(13):6367-79.

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Nucleic Acids Res
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Eur J Hum Genet
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Curr Protoc Hum Genet
Bioessays
Am J Hum Genet