Insulysin

"Insulysin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An enzyme the catalyzes the degradation of insulin, glucagon and other polypeptides. It is inhibited by bacitracin, chelating agents EDTA and 1,10-phenanthroline, and by thiol-blocking reagents such as N-ethylmaleimide, but not phosphoramidon. (Eur J Biochem 1994;223:1-5) EC 3.4.24.56.

Descriptor ID

D007339

MeSH Number(s)

D08.811.277.656.300.480.300

D08.811.277.656.675.374.300

Concept/Terms

Insulysin

Below are MeSH descriptors whose meaning is more general than "Insulysin".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Peptide Hydrolases [D08.811.277.656]
Endopeptidases [D08.811.277.656.300]
Metalloendopeptidases [D08.811.277.656.300.480]
Insulysin [D08.811.277.656.300.480.300]
Metalloproteases [D08.811.277.656.675]
Metalloendopeptidases [D08.811.277.656.675.374]
Insulysin [D08.811.277.656.675.374.300]

Below are MeSH descriptors whose meaning is related to "Insulysin".

Below are MeSH descriptors whose meaning is more specific than "Insulysin".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Insulysin" by people in Harvard Catalyst Profiles by year, and whether "Insulysin" was a major or minor topic of these publication.

Bar chart showing 28 publications over 15 distinct years, with a maximum of 4 publications in 2003

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	1	0	1
2000	3	0	3
2001	0	1	1
2002	0	1	1
2003	2	2	4
2004	2	1	3
2005	1	0	1
2006	2	0	2
2007	2	1	3
2008	1	1	2
2009	1	0	1
2010	2	0	2
2011	0	1	1
2012	1	1	2
2020	1	0	1

Below are the most recent publications written about "Insulysin" by people in Profiles.

Microglia Do Not Take Up Soluble Amyloid-beta Peptides, But Partially Degrade Them by Secreting Insulin-degrading Enzyme. Neuroscience. 2020 09 01; 443:30-43.

View in: PubMed
Bile acid TUDCA improves insulin clearance by increasing the expression of insulin-degrading enzyme in the liver of obese mice. Sci Rep. 2017 11 01; 7(1):14876.

View in: PubMed
The effect of taurine supplementation on glucose homeostasis: the role of insulin-degrading enzyme. Adv Exp Med Biol. 2015; 803:715-24.

View in: PubMed
Insulin-degrading enzyme deficiency accelerates cerebrovascular amyloidosis in an animal model. Brain Behav Immun. 2013 May; 30:143-9.

View in: PubMed
The association between small vessel infarcts and the activities of amyloid-ß peptide degrading proteases in apolipoprotein E4 allele carriers. Angiology. 2013 Nov; 64(8):614-20.

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Discovery by the Epistasis Project of an epistatic interaction between the GSTM3 gene and the HHEX/IDE/KIF11 locus in the risk of Alzheimer's disease. Neurobiol Aging. 2013 Apr; 34(4):1309.e1-7.

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17ß-estradiol and progesterone regulate expression of ß-amyloid clearance factors in primary neuron cultures and female rat brain. Endocrinology. 2012 Nov; 153(11):5467-79.

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Structure based discovery of small molecules to regulate the activity of human insulin degrading enzyme. PLoS One. 2012; 7(2):e31787.

View in: PubMed
Cerebrovascular lesions induce transient ß-amyloid deposition. Brain. 2011 Dec; 134(Pt 12):3697-707.

View in: PubMed
Association between variants in IDE-KIF11-HHEX and plasma amyloid ß levels. Neurobiol Aging. 2012 Jan; 33(1):199.e13-7.

View in: PubMed

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