Integrin alpha5

"Integrin alpha5" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

This integrin alpha subunit combines with INTEGRIN BETA1 to form a receptor (INTEGRIN ALPHA5BETA1) that binds FIBRONECTIN and LAMININ. It undergoes posttranslational cleavage into a heavy and a light chain that are connected by disulfide bonds.

Descriptor ID

D039482

MeSH Number(s)

D12.776.543.750.705.408.100.500

D23.050.301.264.035.293

D23.101.100.110.294

Concept/Terms

Integrin alpha5

Below are MeSH descriptors whose meaning is more general than "Integrin alpha5".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Membrane Proteins [D12.776.543]
Receptors, Cell Surface [D12.776.543.750]
Receptors, Immunologic [D12.776.543.750.705]
Integrins [D12.776.543.750.705.408]
Integrin alpha Chains [D12.776.543.750.705.408.100]
Integrin alpha5 [D12.776.543.750.705.408.100.500]
Biological Factors [D23]
Antigens [D23.050]
Antigens, Surface [D23.050.301]
Antigens, Differentiation [D23.050.301.264]
Antigens, CD [D23.050.301.264.035]
Integrin alpha5 [D23.050.301.264.035.293]
Biological Markers [D23.101]
Antigens, Differentiation [D23.101.100]
Antigens, CD [D23.101.100.110]
Integrin alpha5 [D23.101.100.110.294]

Below are MeSH descriptors whose meaning is related to "Integrin alpha5".

Below are MeSH descriptors whose meaning is more specific than "Integrin alpha5".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Integrin alpha5" by people in Harvard Catalyst Profiles by year, and whether "Integrin alpha5" was a major or minor topic of these publication.

Bar chart showing 17 publications over 15 distinct years, with a maximum of 2 publications in 2011 and 2016

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	0	1	1
1998	0	1	1
1999	0	1	1
2001	0	1	1
2002	0	1	1
2005	1	0	1
2006	1	0	1
2009	0	1	1
2010	1	0	1
2011	1	1	2
2012	0	1	1
2016	2	0	2
2017	0	1	1
2020	0	1	1
2022	1	0	1

Below are the most recent publications written about "Integrin alpha5" by people in Profiles.

Integrin a5 Is Regulated by miR-218-5p in Endothelial Progenitor Cells. J Am Soc Nephrol. 2022 03; 33(3):565-582.

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Cholesteryl a-D-glucoside 6-acyltransferase enhances the adhesion of Helicobacter pylori to gastric epithelium. Commun Biol. 2020 03 13; 3(1):120.

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Proapoptotic PUMA targets stem-like breast cancer cells to suppress metastasis. J Clin Invest. 2018 01 02; 128(1):531-544.

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Modulation of infection-mediated migration of neutrophils and CXCR2 trafficking by osteopontin. Immunology. 2017 Jan; 150(1):74-86.

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Interaction between integrin a5 and PDE4D regulates endothelial inflammatory signalling. Nat Cell Biol. 2016 10; 18(10):1043-53.

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Interepithelial signaling with nephric duct is required for the formation of overlying coelomic epithelial cell sheet. Proc Natl Acad Sci U S A. 2014 May 06; 111(18):6660-5.

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Prolactin stimulates cell migration and invasion by human trophoblast in vitro. Placenta. 2013 Sep; 34(9):775-83.

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Sulfatides inhibit adhesion, migration, and invasion of murine melanoma B16F10 cell line in vitro. Biol Pharm Bull. 2012; 35(11):2054-8.

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Rv2468c, a novel Mycobacterium tuberculosis protein that costimulates human CD4+ T cells through VLA-5. J Leukoc Biol. 2012 Feb; 91(2):311-20.

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The interaction between caveolin-1 and Rho-GTPases promotes metastasis by controlling the expression of alpha5-integrin and the activation of Src, Ras and Erk. Oncogene. 2012 Feb 16; 31(7):884-96.

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