Enkephalin, Leucine-2-Alanine
"Enkephalin, Leucine-2-Alanine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A delta-selective opioid (ANALGESICS, OPIOID). It can cause transient depression of mean arterial blood pressure and heart rate.
Concept/Terms
Enkephalin, Leucine-2-Alanine- Enkephalin, Leucine-2-Alanine
- Enkephalin, Leucine 2 Alanine
- Leucine-2-Alanine Enkephalin
- 5-Leucine-2-Alanine Enkephalin
- 5 Leucine 2 Alanine Enkephalin
- Enkephalin, 5-Leucine-2-Alanine
- Leucine Enkephalin-2-Alanine
- Enkephalin-2-Alanine, Leucine
- Leucine Enkephalin 2 Alanine
- DADLE
- Enkephalin-Leu,Ala(2)
- Leu-Enkephalin-2-Ala
- Leu Enkephalin 2 Ala
- 2-Alanyl-Leucine Enkephalin
- 2 Alanyl Leucine Enkephalin
- Enkephalin, 2-Alanyl-Leucine
- D-Ala(2)-D-Leu(5)-Enkephalin
Below are MeSH descriptors whose meaning is more general than "Enkephalin, Leucine-2-Alanine".
Below are MeSH descriptors whose meaning is more specific than "Enkephalin, Leucine-2-Alanine".
This graph shows the total number of publications written about "Enkephalin, Leucine-2-Alanine" by people in Harvard Catalyst Profiles by year, and whether "Enkephalin, Leucine-2-Alanine" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1995 | 0 | 1 | 1 |
2002 | 1 | 0 | 1 |
Below are the most recent publications written about "Enkephalin, Leucine-2-Alanine" by people in Profiles.
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Differential effects of opioid agonists on G protein expression in CHO cells expressing cloned human opioid receptors. Brain Res Bull. 2008 Sep 05; 77(1):49-54.
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Quantitative analysis of a model opioid peptide and its cyclic prodrugs in rat plasma using high-performance liquid chromatography with fluorescence and tandem mass spectrometric detection. J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Nov 25; 780(2):269-81.
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Evaluation of the permeation characteristics of a model opioid peptide, H-Tyr-D-Ala-Gly-Phe-D-Leu-OH (DADLE), and its cyclic prodrugs across the blood-brain barrier using an in situ perfused rat brain model. J Pharmacol Exp Ther. 2002 Nov; 303(2):849-57.
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In vitro stability and in vivo pharmacokinetic studies of a model opioid peptide, H-Tyr-D-Ala-Gly-Phe-D-Leu-OH (DADLE), and its cyclic prodrugs. J Pharmacol Exp Ther. 2002 Nov; 303(2):840-8.
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Delta opiates increase ischemic tolerance in isolated rabbit jejunum. Acad Emerg Med. 2002 Jun; 9(6):555-60.
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Calcium influx in rat thalamic relay neurons through voltage-dependent calcium channels is inhibited by enkephalin. Neurosci Lett. 1995 Dec 01; 201(1):21-4.
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Two distinct modulatory effects on calcium channels in adult rat sensory neurons. Biophys J. 1993 Apr; 64(4):1029-37.
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Opioid receptor agonists and Ca2+ modulation in human B cell lines. J Immunol. 1992 Dec 15; 149(12):4074-81.
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Ethanol increases the expression of functional delta-opioid receptors in neuroblastoma x glioma NG108-15 hybrid cells. J Biol Chem. 1986 Mar 05; 261(7):3164-9.
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Gamma-aminobutyric acid and benzodiazepine receptor changes induced by unilateral 6-hydroxydopamine lesions of the medial forebrain bundle. J Neurochem. 1985 Nov; 45(5):1396-404.