Gene Therapy

"Gene Therapy" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The introduction of new genes into cells for the purpose of treating disease by restoring or adding gene expression. Techniques include insertion of retroviral vectors, transfection, homologous recombination, and injection of new genes into the nuclei of single cell embryos. The entire gene therapy process may consist of multiple steps. The new genes may be introduced into proliferating cells in vivo (e.g., bone marrow) or in vitro (e.g., fibroblast cultures) and the modified cells transferred to the site where the gene expression is required. Gene therapy may be particularly useful for treating enzyme deficiency diseases, hemoglobinopathies, and leukemias and may also prove useful in restoring drug sensitivity, particularly for leukemia.

Descriptor ID

D015316

MeSH Number(s)

E02.095.301

E05.393.420.301

Concept/Terms

Gene Therapy

Gene Therapy, Somatic

Below are MeSH descriptors whose meaning is more general than "Gene Therapy".

Analytical, Diagnostic and Therapeutic Techniques and Equipment [E]
Therapeutics [E02]
Biological Therapy [E02.095]
Gene Therapy [E02.095.301]
Investigative Techniques [E05]
Genetic Techniques [E05.393]
Genetic Engineering [E05.393.420]
Gene Therapy [E05.393.420.301]

Below are MeSH descriptors whose meaning is related to "Gene Therapy".

Below are MeSH descriptors whose meaning is more specific than "Gene Therapy".

Gene Therapy
Targeted Gene Repair

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Gene Therapy" by people in Harvard Catalyst Profiles by year, and whether "Gene Therapy" was a major or minor topic of these publication.

Related Networks