Methylmalonyl-CoA Mutase

"Methylmalonyl-CoA Mutase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An enzyme that catalyzes the conversion of methylmalonyl-CoA to succinyl-CoA by transfer of the carbonyl group. It requires a cobamide coenzyme. A block in this enzymatic conversion leads to the metabolic disease, methylmalonic aciduria. EC 5.4.99.2.

Descriptor ID

D008765

MeSH Number(s)

D08.811.399.520.625

Concept/Terms

Methylmalonyl-CoA Mutase

Below are MeSH descriptors whose meaning is more general than "Methylmalonyl-CoA Mutase".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Isomerases [D08.811.399]
Intramolecular Transferases [D08.811.399.520]
Methylmalonyl-CoA Mutase [D08.811.399.520.625]

Below are MeSH descriptors whose meaning is related to "Methylmalonyl-CoA Mutase".

Below are MeSH descriptors whose meaning is more specific than "Methylmalonyl-CoA Mutase".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Methylmalonyl-CoA Mutase" by people in Harvard Catalyst Profiles by year, and whether "Methylmalonyl-CoA Mutase" was a major or minor topic of these publication.

Bar chart showing 12 publications over 10 distinct years, with a maximum of 2 publications in 2009 and 2018

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2006	1	0	1
2009	2	0	2
2012	1	0	1
2013	1	0	1
2014	0	1	1
2015	1	0	1
2018	2	0	2
2019	1	0	1
2022	1	0	1
2023	1	0	1

Below are the most recent publications written about "Methylmalonyl-CoA Mutase" by people in Profiles.

Structural insight into G-protein chaperone-mediated maturation of a bacterial adenosylcobalamin-dependent mutase. J Biol Chem. 2023 09; 299(9):105109.

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Review of neuropsychological outcomes in isolated methylmalonic acidemia: recommendations for assessing impact of treatments. Metab Brain Dis. 2022 06; 37(5):1317-1335.

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Itaconyl-CoA forms a stable biradical in methylmalonyl-CoA mutase and derails its activity and repair. Science. 2019 11 01; 366(6465):589-593.

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FGF21 underlies a hormetic response to metabolic stress in methylmalonic acidemia. JCI Insight. 2018 12 06; 3(23).

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Label-Free Quantitative Proteomics in a Methylmalonyl-CoA Mutase-Silenced Neuroblastoma Cell Line. Int J Mol Sci. 2018 Nov 13; 19(11).

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Cofactor Editing by the G-protein Metallochaperone Domain Regulates the Radical B12 Enzyme IcmF. J Biol Chem. 2017 03 10; 292(10):3977-3987.

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Visualization of a radical B12 enzyme with its G-protein chaperone. Proc Natl Acad Sci U S A. 2015 Feb 24; 112(8):2419-24.

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Methylmalonic acidemia: a megamitochondrial disorder affecting the kidney. Pediatr Nephrol. 2014 Nov; 29(11):2139-46.

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Targeting proximal tubule mitochondrial dysfunction attenuates the renal disease of methylmalonic acidemia. Proc Natl Acad Sci U S A. 2013 Aug 13; 110(33):13552-7.

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Treatment of a methylmalonyl-CoA mutase stopcodon mutation. Biochem Biophys Res Commun. 2012 Nov 02; 427(4):753-7.

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