Metabolic Detoxication, Phase I
"Metabolic Detoxication, Phase I" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Functionalization of exogenous substances to prepare them for conjugation in PHASE II DETOXIFICATION. Phase I enzymes include CYTOCHROME P450 enzymes and some OXIDOREDUCTASES. Excess induction of phase I over phase II detoxification leads to higher levels of FREE RADICALS that can induce CANCER and other cell damage. Induction or antagonism of phase I detoxication is the basis of a number of DRUG INTERACTIONS.
MeSH Number(s)
G03.495.244.820.500
G07.690.812.097.600.500
G07.700.680.097.600.500
Concept/Terms
Metabolic Detoxication, Phase I- Metabolic Detoxication, Phase I
- Metabolic Detoxication, Oxidative
- Detoxication, Oxidative Metabolic
- Detoxications, Oxidative Metabolic
- Metabolic Detoxications, Oxidative
- Oxidative Metabolic Detoxication
- Oxidative Metabolic Detoxications
- Phase I Detoxification
- Detoxification, Phase I
- Detoxifications, Phase I
- Metabolic Detoxification, Phase I
Below are MeSH descriptors whose meaning is more general than "Metabolic Detoxication, Phase I".
Below are MeSH descriptors whose meaning is more specific than "Metabolic Detoxication, Phase I".
This graph shows the total number of publications written about "Metabolic Detoxication, Phase I" by people in Harvard Catalyst Profiles by year, and whether "Metabolic Detoxication, Phase I" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 2 | 0 | 2 |
| 2008 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
Below are the most recent publications written about "Metabolic Detoxication, Phase I" by people in Profiles.
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A cytoprotective perspective on longevity regulation. Trends Cell Biol. 2013 Sep; 23(9):409-20.
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Phase I metabolic genes and risk of lung cancer: multiple polymorphisms and mRNA expression. PLoS One. 2009 May 21; 4(5):e5652.
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Polymorphisms in phase I and phase II metabolism genes and risk of chronic benzene poisoning in a Chinese occupational population. Carcinogenesis. 2008 Dec; 29(12):2325-9.
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Increased risk of acute myeloid leukaemia due to polymorphisms in detoxification and DNA repair enzymes. Ann Oncol. 2007 Sep; 18(9):1523-8.
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Development of lung cancer before the age of 50: the role of xenobiotic metabolizing genes. Carcinogenesis. 2007 Jun; 28(6):1287-93.