Receptor, Ciliary Neurotrophic Factor
"Receptor, Ciliary Neurotrophic Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Cell surface receptors for CILIARY NEUROTROPHIC FACTOR. They are heterotrimeric proteins formed by the association of the CILIARY NEUROTROPHIC FACTOR RECEPTOR ALPHA SUBUNIT with the LEUKEMIA INHIBITORY FACTOR RECEPTOR ALPHA SUBUNIT and the CYTOKINE RECEPTOR GP130. Although the receptor regulates neuronal development, it is structurally similar to the cytokine receptor for INTERLEUKIN-6; (RECEPTORS, INTERLEUKIN-6).
MeSH Number(s)
D12.776.543.750.750.400.550.250
Below are MeSH descriptors whose meaning is more general than "Receptor, Ciliary Neurotrophic Factor".
Below are MeSH descriptors whose meaning is more specific than "Receptor, Ciliary Neurotrophic Factor".
This graph shows the total number of publications written about "Receptor, Ciliary Neurotrophic Factor" by people in Harvard Catalyst Profiles by year, and whether "Receptor, Ciliary Neurotrophic Factor" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 1995 | 0 | 4 | 4 |
| 1996 | 0 | 4 | 4 |
| 1997 | 0 | 2 | 2 |
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 4 | 4 |
| 2001 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 1 | 0 | 1 |
| 2007 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
| 2011 | 0 | 1 | 1 |
Below are the most recent publications written about "Receptor, Ciliary Neurotrophic Factor" by people in Profiles.
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CNTF mediates neurotrophic factor secretion and fluid absorption in human retinal pigment epithelium. PLoS One. 2011; 6(9):e23148.
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Role of the neurotrophin network in eating disorders' subphenotypes: body mass index and age at onset of the disease. J Psychiatr Res. 2010 Oct; 44(13):834-40.
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Structural organization of a full-length gp130/LIF-R cytokine receptor transmembrane complex. Mol Cell. 2008 Sep 05; 31(5):737-48.
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Up-regulation of ciliary neurotrophic factor receptor expression by GABAA receptors in undifferentiated neural progenitors of fetal mouse brain. J Neurosci Res. 2008 Sep; 86(12):2615-23.
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Activation of the ciliary neurotrophic factor (CNTF) signalling pathway in cortical neurons of multiple sclerosis patients. Brain. 2007 Oct; 130(Pt 10):2566-76.
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Activation of the cardiac ciliary neurotrophic factor receptor reverses left ventricular hypertrophy in leptin-deficient and leptin-resistant obesity. Proc Natl Acad Sci U S A. 2006 Mar 14; 103(11):4222-7.
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Neurogenesis in the hypothalamus of adult mice: potential role in energy balance. Science. 2005 Oct 28; 310(5748):679-83.
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Ciliary neurotrophic factor and its receptors are differentially expressed in the optic nerve transected adult rat retina. Brain Res. 2004 Jul 09; 1013(2):152-8.
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Termination and modulation of IL-6-type cytokine signaling. Adv Exp Med Biol. 2001; 495:153-60.
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Bipotent cortical progenitor cells process conflicting cues for neurons and glia in a hierarchical manner. J Neurosci. 1999 Dec 01; 19(23):10383-9.