Cleavage And Polyadenylation Specificity Factor
"Cleavage And Polyadenylation Specificity Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An RNA-binding protein that recognizes the AAUAAA RNA SEQUENCE at the 3' end of MRNA. It contains four subunits of 30, 73, 100 and 160 kDa molecular size and combines with CLEAVAGE STIMULATION FACTOR to form a stable complex with mRNA that directs the 3' cleavage and polyadenylation reaction.
MeSH Number(s)
D12.776.157.725.124.240
D12.776.664.962.444.240
Below are MeSH descriptors whose meaning is more general than "Cleavage And Polyadenylation Specificity Factor".
Below are MeSH descriptors whose meaning is more specific than "Cleavage And Polyadenylation Specificity Factor".
This graph shows the total number of publications written about "Cleavage And Polyadenylation Specificity Factor" by people in Harvard Catalyst Profiles by year, and whether "Cleavage And Polyadenylation Specificity Factor" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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2008 | 1 | 0 | 1 |
2009 | 1 | 0 | 1 |
2010 | 1 | 0 | 1 |
2011 | 1 | 0 | 1 |
2015 | 1 | 0 | 1 |
2017 | 1 | 0 | 1 |
2019 | 1 | 1 | 2 |
2020 | 1 | 0 | 1 |
2022 | 0 | 1 | 1 |
Below are the most recent publications written about "Cleavage And Polyadenylation Specificity Factor" by people in Profiles.
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NUDT21 limits CD19 levels through alternative mRNA polyadenylation in B cell acute lymphoblastic leukemia. Nat Immunol. 2022 10; 23(10):1424-1432.
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Partial loss of CFIm25 causes learning deficits and aberrant neuronal alternative polyadenylation. Elife. 2020 04 22; 9.
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CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing's sarcoma. Nat Chem Biol. 2020 01; 16(1):50-59.
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Transforming growth factor ß1 alters the 3'-UTR of mRNA to promote lung fibrosis. J Biol Chem. 2019 10 25; 294(43):15781-15794.
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CFIm25 and alternative polyadenylation: Conflicting roles in cancer. Cancer Lett. 2019 09 10; 459:112-121.
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Nudt21 Controls Cell Fate by Connecting Alternative Polyadenylation to Chromatin Signaling. Cell. 2018 01 11; 172(1-2):106-120.e21.
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Cleavage and polyadenylation specificity factor 30: An RNA-binding zinc-finger protein with an unexpected 2Fe-2S cluster. Proc Natl Acad Sci U S A. 2016 Apr 26; 113(17):4700-5.
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NUDT21-spanning CNVs lead to neuropsychiatric disease and altered MeCP2 abundance via alternative polyadenylation. Elife. 2015 Aug 27; 4.
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The ubiquitin hydrolase USP22 contributes to 3'-end processing of JAK-STAT-inducible genes. FASEB J. 2012 Feb; 26(2):842-54.
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cpsf1 is required for definitive HSC survival in zebrafish. Blood. 2011 Apr 14; 117(15):3996-4007.