Harvard Catalyst Profiles

Specific loci that show up during KARYOTYPING as a gap (an uncondensed stretch in closer views) on a CHROMATID arm after culturing cells under specific conditions. These sites are associated with an increase in CHROMOSOME FRAGILITY. They are classified as common or rare, and by the specific culture conditions under which they develop. Fragile site loci are named by the letters "FRA" followed by a designation for the specific chromosome, and a letter which refers to which fragile site of that chromosome (e.g. FRAXA refers to fragile site A on the X chromosome. It is a rare, folic acid-sensitive fragile site associated with FRAGILE X SYNDROME.)

Below are MeSH descriptors whose meaning is more general than "Chromosome Fragile Sites".

Below are MeSH descriptors whose meaning is related to "Chromosome Fragile Sites".

Below are MeSH descriptors whose meaning is more specific than "Chromosome Fragile Sites".