"Chromosome Fragile Sites" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Specific loci that show up during KARYOTYPING as a gap (an uncondensed stretch in closer views) on a CHROMATID arm after culturing cells under specific conditions. These sites are associated with an increase in CHROMOSOME FRAGILITY. They are classified as common or rare, and by the specific culture conditions under which they develop. Fragile site loci are named by the letters "FRA" followed by a designation for the specific chromosome, and a letter which refers to which fragile site of that chromosome (e.g. FRAXA refers to fragile site A on the X chromosome. It is a rare, folic acid-sensitive fragile site associated with FRAGILE X SYNDROME.)
Concept/Terms
Chromosome Fragile Sites- Chromosome Fragile Sites
- Chromosome Fragile Site
- Fragile Site, Chromosome
- Site, Chromosome Fragile
- Sites, Chromosome Fragile
- Fragile Sites, Chromosome
Below are MeSH descriptors whose meaning is more general than "Chromosome Fragile Sites".
Below are MeSH descriptors whose meaning is more specific than "Chromosome Fragile Sites".
This graph shows the total number of publications written about "Chromosome Fragile Sites" by people in Harvard Catalyst Profiles by year, and whether "Chromosome Fragile Sites" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2005 | 1 | 0 | 1 |
| 2009 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2015 | 0 | 2 | 2 |
| 2016 | 1 | 0 | 1 |
| 2017 | 0 | 1 | 1 |
| 2018 | 1 | 1 | 2 |
Below are the most recent publications written about "Chromosome Fragile Sites" by people in Profiles.
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Sequence and Nuclease Requirements for Breakage and Healing of a Structure-Forming (AT)n Sequence within Fragile Site FRA16D. Cell Rep. 2019 04 23; 27(4):1151-1164.e5.
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Insights into clonal haematopoiesis from 8,342 mosaic chromosomal alterations. Nature. 2018 07; 559(7714):350-355.
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Replication stress induces accumulation of FANCD2 at central region of large fragile genes. Nucleic Acids Res. 2018 04 06; 46(6):2932-2944.
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Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors. Nat Commun. 2017 10 31; 8(1):1221.
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Distinct hepatitis B virus integration patterns in hepatocellular carcinoma and adjacent normal liver tissue. Int J Cancer. 2017 03 15; 140(6):1324-1330.
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Selectivity of ORC binding sites and the relation to replication timing, fragile sites, and deletions in cancers. Proc Natl Acad Sci U S A. 2016 08 16; 113(33):E4810-9.
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Mammalian RAD51 paralogs protect nascent DNA at stalled forks and mediate replication restart. Nucleic Acids Res. 2015 Nov 16; 43(20):9835-55.
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Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice. Genes Dev. 2015 Apr 01; 29(7):690-5.
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A novel role for the mono-ADP-ribosyltransferase PARP14/ARTD8 in promoting homologous recombination and protecting against replication stress. Nucleic Acids Res. 2015 Mar 31; 43(6):3143-53.
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Interplay between genetic and epigenetic factors governs common fragile site instability in cancer. Cell Mol Life Sci. 2014 Dec; 71(23):4495-506.