"Genetic Heterogeneity" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The presence of apparently similar characters for which the genetic evidence indicates that different genes or different genetic mechanisms are involved in different pedigrees. In clinical settings genetic heterogeneity refers to the presence of a variety of genetic defects which cause the same disease, often due to mutations at different loci on the same gene, a finding common to many human diseases including ALZHEIMER DISEASE; CYSTIC FIBROSIS; LIPOPROTEIN LIPASE DEFICIENCY, FAMILIAL; and POLYCYSTIC KIDNEY DISEASES. (Rieger, et al., Glossary of Genetics: Classical and Molecular, 5th ed; Segen, Dictionary of Modern Medicine, 1992)
Concept/Terms
Genetic Heterogeneity- Genetic Heterogeneity
- Heterogeneity, Genetic
- Genetic Heterogeneities
- Heterogeneities, Genetic
Below are MeSH descriptors whose meaning is more general than "Genetic Heterogeneity".
Below are MeSH descriptors whose meaning is more specific than "Genetic Heterogeneity".
This graph shows the total number of publications written about "Genetic Heterogeneity" by people in Harvard Catalyst Profiles by year, and whether "Genetic Heterogeneity" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 5 | 2 | 7 |
| 1996 | 2 | 3 | 5 |
| 1997 | 2 | 8 | 10 |
| 1998 | 4 | 4 | 8 |
| 1999 | 2 | 2 | 4 |
| 2000 | 4 | 6 | 10 |
| 2001 | 4 | 12 | 16 |
| 2002 | 3 | 5 | 8 |
| 2003 | 1 | 5 | 6 |
| 2004 | 3 | 7 | 10 |
| 2005 | 3 | 3 | 6 |
| 2006 | 0 | 6 | 6 |
| 2007 | 5 | 4 | 9 |
| 2008 | 3 | 5 | 8 |
| 2009 | 4 | 7 | 11 |
| 2010 | 5 | 5 | 10 |
| 2011 | 4 | 10 | 14 |
| 2012 | 7 | 8 | 15 |
| 2013 | 9 | 8 | 17 |
| 2014 | 11 | 20 | 31 |
| 2015 | 7 | 15 | 22 |
| 2016 | 9 | 17 | 26 |
| 2017 | 11 | 9 | 20 |
| 2018 | 6 | 10 | 16 |
| 2019 | 5 | 14 | 19 |
| 2020 | 10 | 15 | 25 |
| 2021 | 7 | 16 | 23 |
| 2022 | 2 | 1 | 3 |
| 2023 | 1 | 3 | 4 |
Below are the most recent publications written about "Genetic Heterogeneity" by people in Profiles.
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Hallmarks of transcriptional intratumour heterogeneity across a thousand tumours. Nature. 2023 Jun; 618(7965):598-606.
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Dissecting the genetic heterogeneity of gastric cancer. EBioMedicine. 2023 Jun; 92:104616.
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Genome-wide association study of obstructive sleep apnoea in the Million Veteran Program uncovers genetic heterogeneity by sex. EBioMedicine. 2023 Apr; 90:104536.
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The immune microenvironment shapes transcriptional and genetic heterogeneity in chronic lymphocytic leukemia. Blood Adv. 2023 01 10; 7(1):145-158.
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Genetic Heterogeneity Shapes Brain Connectivity in Psychiatry. Biol Psychiatry. 2023 01 01; 93(1):45-58.
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ENPP1 variants in patients with GACI and PXE expand the clinical and genetic heterogeneity of heritable disorders of ectopic calcification. PLoS Genet. 2022 04; 18(4):e1010192.
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Deciphering spatial genomic heterogeneity at a single cell resolution in multiple myeloma. Nat Commun. 2022 02 10; 13(1):807.
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Single-cell analysis of human primary prostate cancer reveals the heterogeneity of tumor-associated epithelial cell states. Nat Commun. 2022 01 10; 13(1):141.
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Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps. Cell. 2021 12 22; 184(26):6262-6280.e26.
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Tumor evolution selectively inactivates the core microRNA machinery for immune evasion. Nat Commun. 2021 12 01; 12(1):7003.