Munc18 Proteins

"Munc18 Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A family of proteins involved in intracellular membrane trafficking. They interact with SYNTAXINS and play important roles in vesicular docking and fusion during EXOCYTOSIS. Their name derives from the fact that they are related to Unc-18 protein, C elegans.

Descriptor ID

D051938

MeSH Number(s)

D12.776.543.990.587

Concept/Terms

Below are MeSH descriptors whose meaning is more general than "Munc18 Proteins".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Membrane Proteins [D12.776.543]
Vesicular Transport Proteins [D12.776.543.990]
Munc18 Proteins [D12.776.543.990.587]

Below are MeSH descriptors whose meaning is related to "Munc18 Proteins".

Below are MeSH descriptors whose meaning is more specific than "Munc18 Proteins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Munc18 Proteins" by people in Harvard Catalyst Profiles by year, and whether "Munc18 Proteins" was a major or minor topic of these publication.

Bar chart showing 24 publications over 14 distinct years, with a maximum of 4 publications in 2007

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	0	1	1
1999	0	1	1
2007	2	2	4
2011	2	0	2
2013	0	1	1
2015	0	1	1
2016	2	0	2
2017	2	1	3
2018	0	1	1
2019	1	1	2
2020	1	1	2
2021	1	1	2
2022	0	1	1
2023	0	1	1

Below are the most recent publications written about "Munc18 Proteins" by people in Profiles.

Natural History and Developmental Trajectories of Individuals With Disease-Causing Variants in STXBP1. Neurology. 2023 08 29; 101(9):e879-e891.

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Assessing the landscape of STXBP1-related disorders in 534 individuals. Brain. 2022 06 03; 145(5):1668-1683.

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Presynaptic Short-Term Plasticity Persists in the Absence of PKC Phosphorylation of Munc18-1. J Neurosci. 2021 09 01; 41(35):7329-7339.

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Confirming the contribution and genetic spectrum of de novo mutation in infantile spasms: Evidence from a Chinese cohort. Mol Genet Genomic Med. 2021 06; 9(6):e1689.

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Targeted stabilization of Munc18-1 function via pharmacological chaperones. EMBO Mol Med. 2021 01 11; 13(1):e12354.

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Semantic Similarity Analysis Reveals Robust Gene-Disease Relationships in Developmental and Epileptic Encephalopathies. Am J Hum Genet. 2020 10 01; 107(4):683-697.

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De novo STXBP1 mutation in a child with developmental delay and spasticity reveals a major structural alteration in the interface with syntaxin 1A. Am J Med Genet B Neuropsychiatr Genet. 2020 10; 183(7):412-422.

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In vitro fusion of single synaptic and dense core vesicles reproduces key physiological properties. Nat Commun. 2019 08 29; 10(1):3904.

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Impaired cortico-striatal excitatory transmission triggers epilepsy. Nat Commun. 2019 04 23; 10(1):1917.

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Insulin regulates astrocyte gliotransmission and modulates behavior. J Clin Invest. 2018 07 02; 128(7):2914-2926.

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