Cyclin D

"Cyclin D" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A cyclin subtype that is specific for CYCLIN-DEPENDENT KINASE 4 and CYCLIN-DEPENDENT KINASE 6. Unlike most cyclins, cyclin D expression is not cyclical, but rather it is expressed in response to proliferative signals. Cyclin D may therefore play a role in cellular responses to mitogenic signals.

Descriptor ID

D056741

MeSH Number(s)

D12.644.360.262.150

D12.776.167.218.150

D12.776.476.262.150

Concept/Terms

Cyclin D

Below are MeSH descriptors whose meaning is more general than "Cyclin D".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Cyclins [D12.644.360.262]
Cyclin D [D12.644.360.262.150]
Proteins [D12.776]
Cell Cycle Proteins [D12.776.167]
Cyclins [D12.776.167.218]
Cyclin D [D12.776.167.218.150]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Cyclins [D12.776.476.262]
Cyclin D [D12.776.476.262.150]

Below are MeSH descriptors whose meaning is related to "Cyclin D".

Below are MeSH descriptors whose meaning is more specific than "Cyclin D".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Cyclin D" by people in Harvard Catalyst Profiles by year, and whether "Cyclin D" was a major or minor topic of these publication.

Bar chart showing 45 publications over 22 distinct years, with a maximum of 7 publications in 2007

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	2	2
1997	0	2	2
1999	0	2	2
2000	0	1	1
2001	0	3	3
2003	0	2	2
2004	0	1	1
2006	0	5	5
2007	0	7	7
2008	0	2	2
2010	1	0	1
2011	0	1	1
2012	1	1	2
2014	1	1	2
2015	0	2	2
2016	1	1	2
2017	1	2	3
2018	1	0	1
2019	1	0	1
2020	0	1	1
2022	0	1	1
2024	0	1	1

Below are the most recent publications written about "Cyclin D" by people in Profiles.

Quantification of cyclin D1 and D2 proteins in multiple myeloma identifies different expression patterns from those revealed by gene expression profiling. Haematologica. 2024 Mar 01; 109(3):877-887.

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Insights into the aberrant CDK4/6 signaling pathway as a therapeutic target in tumorigenesis. Adv Protein Chem Struct Biol. 2023; 135:179-201.

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Targeting cell-cycle machinery in cancer. Cancer Cell. 2021 06 14; 39(6):759-778.

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Mutations disrupting neuritogenesis genes confer risk for cerebral palsy. Nat Genet. 2020 10; 52(10):1046-1056.

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Cyclin D-CDK4 relieves cooperative repression of proliferation and cell cycle gene expression by DREAM and RB. Oncogene. 2019 06; 38(25):4962-4976.

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Cyclin D/CDK4/6 activity controls G1 length in mammalian cells. PLoS One. 2018; 13(1):e0185637.

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Cyclin D-CDK4 kinase destabilizes PD-L1 via cullin 3-SPOP to control cancer immune surveillance. Nature. 2018 01 04; 553(7686):91-95.

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GLP-1 signalling compensates for impaired insulin signalling in regulating beta cell proliferation in ßIRKO mice. Diabetologia. 2017 08; 60(8):1442-1453.

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Metformin inhibits the proliferation of benign prostatic epithelial cells. PLoS One. 2017; 12(3):e0173335.

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Optimized inducible shRNA and CRISPR/Cas9 platforms for in vitro studies of human development using hPSCs. Development. 2016 12 01; 143(23):4405-4418.

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