Leukemia Inhibitory Factor Receptor alpha Subunit
"Leukemia Inhibitory Factor Receptor alpha Subunit" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A receptor subunit that combines with CYTOKINE RECEPTOR GP130 to form the dual specificity receptor for LEUKEMIA INHIBITORY FACTOR and ONCOSTATIN M. The subunit is also a component of the CILIARY NEUROTROPHIC FACTOR RECEPTOR. Both membrane-bound and secreted isoforms of the receptor subunit exist due to ALTERNATIVE SPLICING of its mRNA. The secreted isoform is believed to act as an inhibitory receptor, while the membrane-bound form is a signaling receptor.
MeSH Number(s)
D12.776.543.750.705.852.500.750
D12.776.543.750.705.852.555.800.750
D12.776.543.750.750.400.550.250.750
D23.050.301.264.035.493
D23.101.100.110.493
Below are MeSH descriptors whose meaning is more general than "Leukemia Inhibitory Factor Receptor alpha Subunit".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Membrane Proteins [D12.776.543]
- Receptors, Cell Surface [D12.776.543.750]
- Receptors, Immunologic [D12.776.543.750.705]
- Receptors, Cytokine [D12.776.543.750.705.852]
- Receptors, OSM-LIF [D12.776.543.750.705.852.500]
- Leukemia Inhibitory Factor Receptor alpha Subunit [D12.776.543.750.705.852.500.750]
- Receptors, Oncostatin M [D12.776.543.750.705.852.555]
- Receptors, OSM-LIF [D12.776.543.750.705.852.555.800]
- Leukemia Inhibitory Factor Receptor alpha Subunit [D12.776.543.750.705.852.555.800.750]
- Receptors, Peptide [D12.776.543.750.750]
- Receptors, Growth Factor [D12.776.543.750.750.400]
- Receptors, Nerve Growth Factor [D12.776.543.750.750.400.550]
- Receptor, Ciliary Neurotrophic Factor [D12.776.543.750.750.400.550.250]
- Leukemia Inhibitory Factor Receptor alpha Subunit [D12.776.543.750.750.400.550.250.750]
- Biological Factors [D23]
- Antigens [D23.050]
- Antigens, Surface [D23.050.301]
- Antigens, Differentiation [D23.050.301.264]
- Antigens, CD [D23.050.301.264.035]
- Leukemia Inhibitory Factor Receptor alpha Subunit [D23.050.301.264.035.493]
- Biological Markers [D23.101]
- Antigens, Differentiation [D23.101.100]
- Antigens, CD [D23.101.100.110]
- Leukemia Inhibitory Factor Receptor alpha Subunit [D23.101.100.110.493]
Below are MeSH descriptors whose meaning is more specific than "Leukemia Inhibitory Factor Receptor alpha Subunit".
This graph shows the total number of publications written about "Leukemia Inhibitory Factor Receptor alpha Subunit" by people in Harvard Catalyst Profiles by year, and whether "Leukemia Inhibitory Factor Receptor alpha Subunit" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 2 | 2 |
| 2004 | 0 | 2 | 2 |
| 2006 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 1 | 0 | 1 |
| 2013 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
Below are the most recent publications written about "Leukemia Inhibitory Factor Receptor alpha Subunit" by people in Profiles.
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Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma. Cancer Cell. 2021 06 14; 39(6):779-792.e11.
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Frequent PLAG1 gene rearrangements in skin and soft tissue myoepithelioma with ductal differentiation. Genes Chromosomes Cancer. 2013 Jul; 52(7):675-82.
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LIFR is a breast cancer metastasis suppressor upstream of the Hippo-YAP pathway and a prognostic marker. Nat Med. 2012 Oct; 18(10):1511-7.
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Two common SNPs in pri-miR-125a alter the mature miRNA expression and associate with recurrent pregnancy loss in a Han-Chinese population. RNA Biol. 2011 Sep-Oct; 8(5):861-72.
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SHP2 is a downstream target of ZAP70 to regulate JAK1/STAT3 and ERK signaling pathways in mouse embryonic stem cells. FEBS Lett. 2010 Oct 08; 584(19):4241-6.
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Treg versus Th17 lymphocyte lineages are cross-regulated by LIF versus IL-6. Cell Cycle. 2009 May 01; 8(9):1444-50.
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Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway. Genes Dev. 2008 Feb 15; 22(4):449-62.
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In vivo phage display selection yields atherosclerotic plaque targeted peptides for imaging. Mol Imaging Biol. 2006 Jul-Aug; 8(4):201-7.
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Ciliary neurotrophic factor and its receptors are differentially expressed in the optic nerve transected adult rat retina. Brain Res. 2004 Jul 09; 1013(2):152-8.
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Leptin-induced increase in leukemia inhibitory factor and its receptor by human endometrium is partially mediated by interleukin 1 receptor signaling. Endocrinology. 2004 Aug; 145(8):3850-7.