EF Hand Motifs

"EF Hand Motifs" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Calcium-binding motifs composed of two helixes (E and F) joined by a loop. Calcium is bound by the loop region. These motifs are found in many proteins that are regulated by calcium.

Descriptor ID

D020832

MeSH Number(s)

G02.111.570.790.709.600.040.360.240

Concept/Terms

EF Hand Motifs

Below are MeSH descriptors whose meaning is more general than "EF Hand Motifs".

Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Molecular Structure [G02.111.570]
Molecular Conformation [G02.111.570.790]
Protein Conformation [G02.111.570.790.709]
Protein Structure, Secondary [G02.111.570.790.709.600]
Amino Acid Motifs [G02.111.570.790.709.600.040]
Helix-Loop-Helix Motifs [G02.111.570.790.709.600.040.360]
EF Hand Motifs [G02.111.570.790.709.600.040.360.240]

Below are MeSH descriptors whose meaning is related to "EF Hand Motifs".

Below are MeSH descriptors whose meaning is more specific than "EF Hand Motifs".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "EF Hand Motifs" by people in Harvard Catalyst Profiles by year, and whether "EF Hand Motifs" was a major or minor topic of these publication.

Bar chart showing 12 publications over 9 distinct years, with a maximum of 2 publications in 2000 and 2010 and 2016

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	0	1	1
2000	0	2	2
2009	0	1	1
2010	1	1	2
2013	0	1	1
2016	1	1	2
2017	0	1	1
2018	0	1	1
2019	0	1	1

Below are the most recent publications written about "EF Hand Motifs" by people in Profiles.

Crystal structure of MICU2 and comparison with MICU1 reveal insights into the uniporter gating mechanism. Proc Natl Acad Sci U S A. 2019 02 26; 116(9):3546-3555.

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Luminescent and paramagnetic properties of nanoparticles shed light on their interactions with proteins. Sci Rep. 2018 02 21; 8(1):3420.

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High-affinity cooperative Ca2+ binding by MICU1-MICU2 serves as an on-off switch for the uniporter. EMBO Rep. 2017 08; 18(8):1397-1411.

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Atypical calcium regulation of the PKD2-L1 polycystin ion channel. Elife. 2016 06 27; 5.

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Oncomodulin, an EF-Hand Ca2+ Buffer, Is Critical for Maintaining Cochlear Function in Mice. J Neurosci. 2016 Feb 03; 36(5):1631-5.

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Structure of the small Dictyostelium discoideum myosin light chain MlcB provides insights into MyoB IQ motif recognition. J Biol Chem. 2014 Jun 13; 289(24):17030-42.

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EMRE is an essential component of the mitochondrial calcium uniporter complex. Science. 2013 Dec 13; 342(6164):1379-82.

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FH8--a small EF-hand protein from Fasciola hepatica. FEBS J. 2010 Dec; 277(24):5072-85.

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MICU1 encodes a mitochondrial EF hand protein required for Ca(2+) uptake. Nature. 2010 Sep 16; 467(7313):291-6.

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The carboxyterminal EF domain of erythroid alpha-spectrin is necessary for optimal spectrin-actin binding. Blood. 2010 Oct 07; 116(14):2600-7.

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