HIV Integrase

"HIV Integrase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Enzyme of the HUMAN IMMUNODEFICIENCY VIRUS that is required to integrate viral DNA into cellular DNA in the nucleus of a host cell. HIV integrase is a DNA nucleotidyltransferase encoded by the pol gene.

Descriptor ID

D019427

MeSH Number(s)

D08.811.739.500.667.500

D08.811.913.696.445.825.500

D12.776.964.775.375.545.500

D12.776.964.775.562.875.500

D12.776.964.970.600.850.375.545.500

Concept/Terms

HIV Integrase

Below are MeSH descriptors whose meaning is more general than "HIV Integrase".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Recombinases [D08.811.739]
Integrases [D08.811.739.500]
Transposases [D08.811.739.500.667]
HIV Integrase [D08.811.739.500.667.500]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Nucleotidyltransferases [D08.811.913.696.445]
Transposases [D08.811.913.696.445.825]
HIV Integrase [D08.811.913.696.445.825.500]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Viral Proteins [D12.776.964]
Retroviridae Proteins [D12.776.964.775]
Gene Products, pol [D12.776.964.775.375]
pol Gene Products, Human Immunodeficiency Virus [D12.776.964.775.375.545]
HIV Integrase [D12.776.964.775.375.545.500]
Human Immunodeficiency Virus Proteins [D12.776.964.775.562]
pol Gene Products, Human Immunodeficiency Virus [D12.776.964.775.562.875]
HIV Integrase [D12.776.964.775.562.875.500]
Viral Structural Proteins [D12.776.964.970]
Nucleocapsid Proteins [D12.776.964.970.600]
Viral Core Proteins [D12.776.964.970.600.850]
Gene Products, pol [D12.776.964.970.600.850.375]
pol Gene Products, Human Immunodeficiency Virus [D12.776.964.970.600.850.375.545]
HIV Integrase [D12.776.964.970.600.850.375.545.500]

Below are MeSH descriptors whose meaning is related to "HIV Integrase".

Below are MeSH descriptors whose meaning is more specific than "HIV Integrase".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "HIV Integrase" by people in Harvard Catalyst Profiles by year, and whether "HIV Integrase" was a major or minor topic of these publication.

Bar chart showing 95 publications over 26 distinct years, with a maximum of 7 publications in 2005 and 2020

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	1	0	1
1997	2	1	3
1999	1	0	1
2001	2	0	2
2002	2	1	3
2003	2	0	2
2004	5	0	5
2005	6	1	7
2006	1	2	3
2007	1	2	3
2008	2	1	3
2009	3	3	6
2010	2	1	3
2011	3	2	5
2012	3	2	5
2013	5	0	5
2014	4	0	4
2015	1	0	1
2016	4	1	5
2017	3	1	4
2018	2	0	2
2019	3	0	3
2020	6	1	7
2021	2	4	6
2022	3	0	3
2023	3	0	3

Below are the most recent publications written about "HIV Integrase" by people in Profiles.

Effect of the L74I Polymorphism on Fitness of Cabotegravir-Resistant Variants of Human Immunodeficiency Virus 1 Subtype A6. J Infect Dis. 2023 11 11; 228(10):1352-1356.

View in: PubMed
Changes in Body Mass Index with Longer-term Integrase Inhibitor Use: A Longitudinal Analysis of Data from the Randomized Trial to Prevent Vascular Events in Human Immunodeficiency Virus (REPRIEVE). Clin Infect Dis. 2023 06 08; 76(11):2010-2013.

View in: PubMed
Emerging integrase strand transfer inhibitor drug resistance mutations among children and adults on ART in Tanzania: findings from a national representative HIV drug resistance survey. J Antimicrob Chemother. 2023 03 02; 78(3):779-787.

View in: PubMed
Allosteric Integrase Inhibitor Influences on HIV-1 Integration and Roles of LEDGF/p75 and HDGFL2 Host Factors. Viruses. 2022 08 26; 14(9).

View in: PubMed
Multimodal Functionalities of HIV-1 Integrase. Viruses. 2022 04 28; 14(5).

View in: PubMed
HIV-1 drug resistance and genetic diversity in a cohort of people with HIV-1 in Nigeria. AIDS. 2022 01 01; 36(1):137-146.

View in: PubMed
HIV-1 integrase binding to genomic RNA 5'-UTR induces local structural changes in vitro and in virio. Retrovirology. 2021 11 22; 18(1):37.

View in: PubMed
Factors associated with the emergence of integrase resistance mutations in patients failing dual or triple integrase inhibitor-based regimens in a French national survey. J Antimicrob Chemother. 2021 08 12; 76(9):2400-2406.

View in: PubMed
Structure and function of retroviral integrase. Nat Rev Microbiol. 2022 01; 20(1):20-34.

View in: PubMed
Pre-treatment integrase inhibitor resistance is uncommon in antiretroviral therapy-naive individuals with HIV-1 subtype A1 and D infections in Uganda. AIDS. 2021 06 01; 35(7):1083-1089.

View in: PubMed

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