Harvard Catalyst Profiles

A sequence-related subfamily of ATP-BINDING CASSETTE TRANSPORTERS that actively transport organic substrates. Although considered organic anion transporters, a subset of proteins in this family have also been shown to convey drug resistance to neutral organic drugs. Their cellular function may have clinical significance for CHEMOTHERAPY in that they transport a variety of ANTINEOPLASTIC AGENTS. Overexpression of proteins in this class by NEOPLASMS is considered a possible mechanism in the development of multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although similar in function to P-GLYCOPROTEINS, the proteins in this class share little sequence homology to the p-glycoprotein family of proteins.

Below are MeSH descriptors whose meaning is more general than "Multidrug Resistance-Associated Proteins".

Below are MeSH descriptors whose meaning is related to "Multidrug Resistance-Associated Proteins".

Below are MeSH descriptors whose meaning is more specific than "Multidrug Resistance-Associated Proteins".