Ornithine Decarboxylase

"Ornithine Decarboxylase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A pyridoxal-phosphate protein, believed to be the rate-limiting compound in the biosynthesis of polyamines. It catalyzes the decarboxylation of ornithine to form putrescine, which is then linked to a propylamine moiety of decarboxylated S-adenosylmethionine to form spermidine. EC 4.1.1.17.

Descriptor ID

D009955

MeSH Number(s)

D08.811.520.224.125.425

Concept/Terms

Ornithine Decarboxylase

Below are MeSH descriptors whose meaning is more general than "Ornithine Decarboxylase".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Lyases [D08.811.520]
Carbon-Carbon Lyases [D08.811.520.224]
Carboxy-Lyases [D08.811.520.224.125]
Ornithine Decarboxylase [D08.811.520.224.125.425]

Below are MeSH descriptors whose meaning is related to "Ornithine Decarboxylase".

Below are MeSH descriptors whose meaning is more specific than "Ornithine Decarboxylase".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Ornithine Decarboxylase" by people in Harvard Catalyst Profiles by year, and whether "Ornithine Decarboxylase" was a major or minor topic of these publication.

Bar chart showing 31 publications over 20 distinct years, with a maximum of 4 publications in 1996

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	0	1	1
1995	1	2	3
1996	2	2	4
1997	0	1	1
1998	0	1	1
2001	0	1	1
2003	0	1	1
2004	0	2	2
2006	1	0	1
2008	1	0	1
2009	1	0	1
2010	1	0	1
2011	0	1	1
2013	0	2	2
2014	0	1	1
2015	2	0	2
2019	0	1	1
2020	1	0	1
2021	1	1	2
2022	1	2	3

Below are the most recent publications written about "Ornithine Decarboxylase" by people in Profiles.

Gasdermin D Deficiency in Vascular Smooth Muscle Cells Ameliorates Abdominal Aortic Aneurysm Through Reducing Putrescine Synthesis. Adv Sci (Weinh). 2023 02; 10(5):e2204038.

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Improvement of dermatological symptoms in patients with Bachmann-Bupp syndrome using difluoromethylornithine treatment. Pediatr Dermatol. 2023 May-Jun; 40(3):528-531.

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Ornithine decarboxylase supports ILC3 responses in infectious and autoimmune colitis through positive regulation of IL-22 transcription. Proc Natl Acad Sci U S A. 2022 Nov 08; 119(45):e2214900119.

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Polyamine metabolism is a central determinant of helper T cell lineage fidelity. Cell. 2021 08 05; 184(16):4186-4202.e20.

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ODC (Ornithine Decarboxylase)-Dependent Putrescine Synthesis Maintains MerTK (MER Tyrosine-Protein Kinase) Expression to Drive Resolution. Arterioscler Thromb Vasc Biol. 2021 03; 41(3):e144-e159.

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Inhibition of the polyamine synthesis enzyme ornithine decarboxylase sensitizes triple-negative breast cancer cells to cytotoxic chemotherapy. J Biol Chem. 2020 05 08; 295(19):6263-6277.

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Developing a novel FRET assay, targeting the binding between Antizyme-AZIN. Sci Rep. 2019 03 15; 9(1):4632.

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Ornithine Decarboxylase Is Sufficient for Prostate Tumorigenesis via Androgen Receptor Signaling. Am J Pathol. 2016 12; 186(12):3131-3145.

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Targeting Ornithine Decarboxylase by a-Difluoromethylornithine Inhibits Tumor Growth by Impairing Myeloid-Derived Suppressor Cells. J Immunol. 2016 Jan 15; 196(2):915-23.

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A Polyamine Twist on Hedgehog Signaling. Dev Cell. 2015 Oct 12; 35(1):1-2.

View in: PubMed

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