"Pentylenetetrazole" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
Concept/Terms
Pentylenetetrazole- Pentylenetetrazole
- Pentylenetetrazol
- Pentetrazole
- Leptazole
- Pentamethylenetetrazole
Corasol- Corasol
- Korazole
- Korazol
- Corazol
- Corazole
Below are MeSH descriptors whose meaning is more general than "Pentylenetetrazole".
Below are MeSH descriptors whose meaning is more specific than "Pentylenetetrazole".
This graph shows the total number of publications written about "Pentylenetetrazole" by people in Harvard Catalyst Profiles by year, and whether "Pentylenetetrazole" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1995 | 1 | 0 | 1 |
1997 | 0 | 1 | 1 |
1998 | 0 | 1 | 1 |
2000 | 0 | 2 | 2 |
2002 | 0 | 3 | 3 |
2005 | 1 | 0 | 1 |
2010 | 0 | 3 | 3 |
2011 | 0 | 2 | 2 |
2014 | 0 | 2 | 2 |
2015 | 1 | 3 | 4 |
2016 | 1 | 4 | 5 |
2017 | 0 | 2 | 2 |
2018 | 1 | 3 | 4 |
2019 | 0 | 1 | 1 |
2020 | 1 | 3 | 4 |
2021 | 1 | 0 | 1 |
2022 | 2 | 1 | 3 |
Below are the most recent publications written about "Pentylenetetrazole" by people in Profiles.
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Neuroprotective effects of Lasmiditan and Sumatriptan in an experimental model of post-stroke seizure in mice: Higher effects with concurrent opioid receptors or KATP channels inhibitors. Toxicol Appl Pharmacol. 2022 11 01; 454:116254.
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Pentylenetetrazole preconditioning attenuates severity of status epilepticus induced by lithium-pilocarpine in male rats: evaluation of opioid/NMDA receptors and nitric oxide pathway. Pharmacol Rep. 2022 Aug; 74(4):602-613.
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The possible role of nitric oxide signaling and NMDA receptors in allopurinol effect on maximal electroshock- and pentylenetetrazol-induced seizures in mice. Neurosci Lett. 2022 05 01; 778:136620.
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Factors influencing the acute pentylenetetrazole-induced seizure paradigm and a literature review. Ann Clin Transl Neurol. 2021 07; 8(7):1388-1397.
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Knockout of stim2a Increases Calcium Oscillations in Neurons and Induces Hyperactive-Like Phenotype in Zebrafish Larvae. Int J Mol Sci. 2020 Aug 27; 21(17).
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Interaction of morphine tolerance with pentylenetetrazole-induced seizure threshold in mice: The role of NMDA-receptor/NO pathway. Epilepsy Behav. 2020 11; 112:107343.
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The possible role of nitric oxide in anti-convulsant effects of Naltrindole in seizure-induced by social isolation stress in male mice. Biomed Pharmacother. 2020 Sep; 129:110453.
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Transcranial direct current stimulation (tDCS) affects neuroinflammation parameters and behavioral seizure activity in pentylenetetrazole-induced kindling in rats. Neurosci Lett. 2020 09 14; 735:135162.
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Anticonvulsant Effects of Thalidomide on Pentylenetetrazole-Induced Seizure in Mice: A Role for Opioidergic and Nitrergic Transmissions. Epilepsy Res. 2020 08; 164:106362.
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Anticonvulsant effect of melatonin through ATP-sensitive channels in mice. Fundam Clin Pharmacol. 2020 Feb; 34(1):148-155.