Colorectal Neoplasms, Hereditary Nonpolyposis
"Colorectal Neoplasms, Hereditary Nonpolyposis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A group of autosomal-dominant inherited diseases in which COLON CANCER arises in discrete adenomas. Unlike FAMILIAL POLYPOSIS COLI with hundreds of polyps, hereditary nonpolyposis colorectal neoplasms occur much later, in the fourth and fifth decades. HNPCC has been associated with germline mutations in mismatch repair (MMR) genes. It has been subdivided into Lynch syndrome I or site-specific colonic cancer, and LYNCH SYNDROME II which includes extracolonic cancer.
MeSH Number(s)
C04.588.274.476.411.307.190
C04.700.250
C06.301.371.411.307.190
C06.405.249.411.307.190
C06.405.469.158.356.190
C06.405.469.491.307.190
C16.320.700.250
C18.452.284.255
Concept/Terms
Hereditary Nonpolyposis Colorectal Cancer- Hereditary Nonpolyposis Colorectal Cancer
- Lynch Cancer Family Syndrome I
- Colorectal Cancer Hereditary Nonpolyposis
- Lynch Syndrome I
- Hereditary Nonpolyposis Colon Cancer
- Colon Cancer, Familial Nonpolyposis
- Lynch Syndrome
- Syndrome, Lynch
Below are MeSH descriptors whose meaning is more general than "Colorectal Neoplasms, Hereditary Nonpolyposis".
- Diseases [C]
- Neoplasms [C04]
- Neoplasms by Site [C04.588]
- Digestive System Neoplasms [C04.588.274]
- Gastrointestinal Neoplasms [C04.588.274.476]
- Intestinal Neoplasms [C04.588.274.476.411]
- Colorectal Neoplasms [C04.588.274.476.411.307]
- Colorectal Neoplasms, Hereditary Nonpolyposis [C04.588.274.476.411.307.190]
- Neoplastic Syndromes, Hereditary [C04.700]
- Colorectal Neoplasms, Hereditary Nonpolyposis [C04.700.250]
- Digestive System Diseases [C06]
- Digestive System Neoplasms [C06.301]
- Gastrointestinal Neoplasms [C06.301.371]
- Intestinal Neoplasms [C06.301.371.411]
- Colorectal Neoplasms [C06.301.371.411.307]
- Colorectal Neoplasms, Hereditary Nonpolyposis [C06.301.371.411.307.190]
- Gastrointestinal Diseases [C06.405]
- Gastrointestinal Neoplasms [C06.405.249]
- Intestinal Neoplasms [C06.405.249.411]
- Colorectal Neoplasms [C06.405.249.411.307]
- Colorectal Neoplasms, Hereditary Nonpolyposis [C06.405.249.411.307.190]
- Intestinal Diseases [C06.405.469]
- Colonic Diseases [C06.405.469.158]
- Colorectal Neoplasms [C06.405.469.158.356]
- Colorectal Neoplasms, Hereditary Nonpolyposis [C06.405.469.158.356.190]
- Intestinal Neoplasms [C06.405.469.491]
- Colorectal Neoplasms [C06.405.469.491.307]
- Colorectal Neoplasms, Hereditary Nonpolyposis [C06.405.469.491.307.190]
- Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
- Genetic Diseases, Inborn [C16.320]
- Neoplastic Syndromes, Hereditary [C16.320.700]
- Colorectal Neoplasms, Hereditary Nonpolyposis [C16.320.700.250]
- Nutritional and Metabolic Diseases [C18]
- Metabolic Diseases [C18.452]
- DNA Repair-Deficiency Disorders [C18.452.284]
- Colorectal Neoplasms, Hereditary Nonpolyposis [C18.452.284.255]
Below are MeSH descriptors whose meaning is more specific than "Colorectal Neoplasms, Hereditary Nonpolyposis".
This graph shows the total number of publications written about "Colorectal Neoplasms, Hereditary Nonpolyposis" by people in Harvard Catalyst Profiles by year, and whether "Colorectal Neoplasms, Hereditary Nonpolyposis" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
---|
1994 | 3 | 0 | 3 |
1995 | 3 | 1 | 4 |
1997 | 2 | 0 | 2 |
1998 | 4 | 0 | 4 |
1999 | 4 | 3 | 7 |
2000 | 2 | 0 | 2 |
2001 | 2 | 1 | 3 |
2002 | 2 | 1 | 3 |
2003 | 2 | 1 | 3 |
2004 | 2 | 2 | 4 |
2005 | 7 | 2 | 9 |
2006 | 3 | 0 | 3 |
2007 | 4 | 3 | 7 |
2008 | 7 | 0 | 7 |
2009 | 10 | 0 | 10 |
2010 | 6 | 2 | 8 |
2011 | 8 | 4 | 12 |
2012 | 5 | 3 | 8 |
2013 | 4 | 1 | 5 |
2014 | 6 | 1 | 7 |
2015 | 9 | 2 | 11 |
2016 | 9 | 3 | 12 |
2017 | 10 | 2 | 12 |
2018 | 11 | 0 | 11 |
2019 | 12 | 2 | 14 |
2020 | 6 | 1 | 7 |
2021 | 8 | 1 | 9 |
2022 | 7 | 0 | 7 |
2023 | 11 | 0 | 11 |
Below are the most recent publications written about "Colorectal Neoplasms, Hereditary Nonpolyposis" by people in Profiles.
-
Exercise Training Reduces the Inflammatory Response and Promotes Intestinal Mucosa-Associated Immunity in Lynch Syndrome. Clin Cancer Res. 2023 11 01; 29(21):4361-4372.
-
PREMM5 distinguishes sporadic from Lynch syndrome-associated MMR-deficient/MSI-high colorectal cancer. Fam Cancer. 2023 10; 22(4):459-465.
-
Development of an Electronic Health Record-Based Clinical Decision Support Tool for Patients With Lynch Syndrome. JCO Clin Cancer Inform. 2023 08; 7:e2300024.
-
The "scope" of colorectal cancer screening in Lynch syndrome: is there an optimal interval? J Natl Cancer Inst. 2023 07 06; 115(7):775-777.
-
Serendipity Strikes: How Pursuing Novel Hypotheses Shifted the Paradigm Regarding the Genetic Basis of Colorectal Cancer and Changed Cancer Therapy. Dig Dis Sci. 2023 09; 68(9):3504-3513.
-
Cancer surveillance for transgender and gender diverse patients with Lynch syndrome: a practice resource of the Collaborative Group of the Americas on Inherited Gastrointestinal Cancer. Fam Cancer. 2023 10; 22(4):437-448.
-
Is Appendiceal Cancer a Lynch Syndrome-Associated Cancer? JAMA Oncol. 2023 06 01; 9(6):869.
-
Mismatch Repair Deficiency and Lynch Syndrome Among Adult Patients With Glioma. JCO Precis Oncol. 2023 05; 7:e2200525.
-
Lynch syndrome: influence of additional susceptibility variants on cancer risk. Eur J Hum Genet. 2023 09; 31(9):1078-1082.
-
Clinical factors associated with skin neoplasms in individuals with Lynch syndrome in a longitudinal observational cohort. J Am Acad Dermatol. 2023 06; 88(6):1282-1290.