Proteostasis Deficiencies

"Proteostasis Deficiencies" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Disorders caused by imbalances in the protein homeostasis network - synthesis, folding, and transport of proteins; post-translational modifications; and degradation or clearance of misfolded proteins.

Descriptor ID

D057165

MeSH Number(s)

C18.452.845

Concept/Terms

Proteostasis Deficiencies

Protein Misfolding Disorders

Below are MeSH descriptors whose meaning is more general than "Proteostasis Deficiencies".

Diseases [C]
Nutritional and Metabolic Diseases [C18]
Metabolic Diseases [C18.452]
Proteostasis Deficiencies [C18.452.845]

Below are MeSH descriptors whose meaning is related to "Proteostasis Deficiencies".

Below are MeSH descriptors whose meaning is more specific than "Proteostasis Deficiencies".

Proteostasis Deficiencies
Amyloidosis
TDP-43 Proteinopathies

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Proteostasis Deficiencies" by people in Harvard Catalyst Profiles by year, and whether "Proteostasis Deficiencies" was a major or minor topic of these publication.

Bar chart showing 28 publications over 12 distinct years, with a maximum of 4 publications in 2011 and 2012 and 2014

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2010	1	0	1
2011	2	2	4
2012	1	3	4
2013	2	1	3
2014	3	1	4
2017	2	1	3
2018	2	0	2
2019	0	1	1
2020	3	0	3
2021	1	0	1
2022	0	1	1
2024	1	0	1

Below are the most recent publications written about "Proteostasis Deficiencies" by people in Profiles.

Identification and Analysis of Axolotl Homologs for Proteins Implicated in Human Neurodegenerative Proteinopathies. Genes (Basel). 2024 Feb 28; 15(3).

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A minimal construct of nuclear-import receptor Karyopherin-ß2 defines the regions critical for chaperone and disaggregation activity. J Biol Chem. 2023 02; 299(2):102806.

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ALS-linked PFN1 variants exhibit loss and gain of functions in the context of formin-induced actin polymerization. Proc Natl Acad Sci U S A. 2021 06 08; 118(23).

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The 2021 FASEB Virtual Catalyst Conference on Extracellular and Organismal Proteostasis in Health and Disease, February 3-4, 2021. FASEB J. 2021 06; 35(6):e21631.

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A Rare Kidney Disease To Cure Them All? Towards Mechanism-Based Therapies for Proteinopathies. Trends Mol Med. 2021 04; 27(4):394-409.

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Risk of Transmissibility From Neurodegenerative Disease-Associated Proteins: Experimental Knowns and Unknowns. J Neuropathol Exp Neurol. 2020 11 01; 79(11):1141-1146.

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Proteome-Scale Mapping of Perturbed Proteostasis in Living Cells. Cold Spring Harb Perspect Biol. 2020 02 03; 12(2).

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From the prion-like propagation hypothesis to therapeutic strategies of anti-tau immunotherapy. Acta Neuropathol. 2020 01; 139(1):3-25.

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Factors in the disease severity of ATP1A3 mutations: Impairment, misfolding, and allele competition. Neurobiol Dis. 2019 12; 132:104577.

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PDE1 inhibition facilitates proteasomal degradation of misfolded proteins and protects against cardiac proteinopathy. Sci Adv. 2019 05; 5(5):eaaw5870.

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