Histamine H1 Antagonists, Non-Sedating
"Histamine H1 Antagonists, Non-Sedating" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class of non-sedating drugs that bind to but do not activate histamine receptors (DRUG INVERSE AGONISM), thereby blocking the actions of histamine or histamine agonists. These antihistamines represent a heterogenous group of compounds with differing chemical structures, adverse effects, distribution, and metabolism. Compared to the early (first generation) antihistamines, these non-sedating antihistamines have greater receptor specificity, lower penetration of BLOOD-BRAIN BARRIER, and are less likely to cause drowsiness or psychomotor impairment.
MeSH Number(s)
D27.505.519.625.375.425.400.500
D27.505.696.577.375.425.400.500
Concept/Terms
Histamine H1 Antagonists, Non-Sedating- Histamine H1 Antagonists, Non-Sedating
- Histamine H1 Antagonists, Non Sedating
- Second Generation H1 Antagonists
- H1 Antihistamines, Non-Sedating
- H1 Antihistamines, Non Sedating
- Non-Sedating H1 Antihistamines
- Second Generation Antihistamines
- Antihistamines, Second Generation
Below are MeSH descriptors whose meaning is more general than "Histamine H1 Antagonists, Non-Sedating".
Below are MeSH descriptors whose meaning is more specific than "Histamine H1 Antagonists, Non-Sedating".
This graph shows the total number of publications written about "Histamine H1 Antagonists, Non-Sedating" by people in Harvard Catalyst Profiles by year, and whether "Histamine H1 Antagonists, Non-Sedating" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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2002 | 1 | 0 | 1 |
2003 | 1 | 1 | 2 |
2004 | 1 | 0 | 1 |
2005 | 1 | 0 | 1 |
2006 | 1 | 0 | 1 |
2007 | 3 | 0 | 3 |
2008 | 0 | 2 | 2 |
2017 | 0 | 1 | 1 |
Below are the most recent publications written about "Histamine H1 Antagonists, Non-Sedating" by people in Profiles.
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Investigating the utility of adult zebrafish ex vivo whole hearts to pharmacologically screen hERG channel activator compounds. Am J Physiol Regul Integr Comp Physiol. 2019 12 01; 317(6):R921-R931.
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Peripheral NMDA Receptor/NO System Blockage Inhibits Itch Responses Induced by Chloroquine in Mice. Acta Derm Venereol. 2017 May 08; 97(5):571-577.
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Evidence of a broad histamine footprint on the human exercise transcriptome. J Physiol. 2016 09 01; 594(17):5009-23.
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Assessing the chiral switch: approval and use of single-enantiomer drugs, 2001 to 2011. Am J Manag Care. 2014 Mar 01; 20(3):e90-7.
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Levocetirizine induced hepatotoxicity in a patient with chronic urticaria. Ann Hepatol. 2011 Apr-Jun; 10(2):237-8.
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Olopatadine 0.2% ophthalmic solution: the first ophthalmic antiallergy agent with once-daily dosing. Expert Opin Drug Metab Toxicol. 2008 Apr; 4(4):453-61.
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Analysis of disease-dependent sedative profiles of H(1)-antihistamines by large-scale surveillance using the visual analog scale. Methods Find Exp Clin Pharmacol. 2008 Apr; 30(3):225-30.
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Efficacy of once-daily olopatadine 0.2% ophthalmic solution compared to twice-daily olopatadine 0.1% ophthalmic solution for the treatment of ocular itching induced by conjunctival allergen challenge. Curr Eye Res. 2007 Dec; 32(12):1017-22.
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Diphenhydramine versus nonsedating antihistamines for acute allergic reactions: a literature review. Allergy Asthma Proc. 2007 Jul-Aug; 28(4):418-26.
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Construction of an environmental exposure unit and investigation of the effects of cetirizine hydrochloride on symptoms of cedar pollinosis in Japan. J Investig Allergol Clin Immunol. 2007; 17(3):173-81.