Proton-Coupled Folate Transporter

"Proton-Coupled Folate Transporter" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A symporter protein that couples the transport of FOLIC ACID with HYDROGEN IONS. The transporter functions most effectively under acidic conditions.

Descriptor ID

D058979

MeSH Number(s)

D12.776.157.530.450.074.500.299.625

D12.776.157.530.450.625.217

D12.776.543.585.450.074.500.224.625

D12.776.543.585.450.625.217

Concept/Terms

Proton-Coupled Folate Transporter

Below are MeSH descriptors whose meaning is more general than "Proton-Coupled Folate Transporter".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Membrane Transport Proteins [D12.776.157.530]
Ion Pumps [D12.776.157.530.450]
Anion Transport Proteins [D12.776.157.530.450.074]
Organic Anion Transporters [D12.776.157.530.450.074.500]
Folic Acid Transporters [D12.776.157.530.450.074.500.299]
Proton-Coupled Folate Transporter [D12.776.157.530.450.074.500.299.625]
Symporters [D12.776.157.530.450.625]
Proton-Coupled Folate Transporter [D12.776.157.530.450.625.217]
Membrane Proteins [D12.776.543]
Membrane Transport Proteins [D12.776.543.585]
Ion Pumps [D12.776.543.585.450]
Anion Transport Proteins [D12.776.543.585.450.074]
Organic Anion Transporters [D12.776.543.585.450.074.500]
Folic Acid Transporters [D12.776.543.585.450.074.500.224]
Proton-Coupled Folate Transporter [D12.776.543.585.450.074.500.224.625]
Symporters [D12.776.543.585.450.625]
Proton-Coupled Folate Transporter [D12.776.543.585.450.625.217]

Below are MeSH descriptors whose meaning is related to "Proton-Coupled Folate Transporter".

Below are MeSH descriptors whose meaning is more specific than "Proton-Coupled Folate Transporter".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Proton-Coupled Folate Transporter" by people in Harvard Catalyst Profiles by year, and whether "Proton-Coupled Folate Transporter" was a major or minor topic of these publication.

Bar chart showing 3 publications over 3 distinct years, with a maximum of 1 publications in 2005 and 2009 and 2016

To see the data from this visualization as text, click here.

Year	Minor Topic	Total
2005	1	1
2009	1	1
2016	1	1

Below are the most recent publications written about "Proton-Coupled Folate Transporter" by people in Profiles.

Lysosomal SLC46A3 modulates hepatic cytosolic copper homeostasis. Nat Commun. 2021 01 12; 12(1):290.

View in: PubMed
Maternal iron status during pregnancy compared with neonatal iron status better predicts placental iron transporter expression in humans. FASEB J. 2016 10; 30(10):3541-3550.

View in: PubMed
Structural determinants of human proton-coupled folate transporter oligomerization: role of GXXXG motifs and identification of oligomeric interfaces at transmembrane domains 3 and 6. Biochem J. 2015 Jul 01; 469(1):33-44.

View in: PubMed
The human proton-coupled folate transporter: Biology and therapeutic applications to cancer. Cancer Biol Ther. 2012 Dec; 13(14):1355-73.

View in: PubMed
Functional loss of the reduced folate carrier enhances the antitumor activities of novel antifolates with selective uptake by the proton-coupled folate transporter. Mol Pharmacol. 2012 Oct; 82(4):591-600.

View in: PubMed
Synthesis, biological, and antitumor activity of a highly potent 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitor with proton-coupled folate transporter and folate receptor selectivity over the reduced folate carrier that inhibits ß-glycinamide ribonucleotide formyltransferase. J Med Chem. 2011 Oct 27; 54(20):7150-64.

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Targeting the proton-coupled folate transporter for selective delivery of 6-substituted pyrrolo[2,3-d]pyrimidine antifolate inhibitors of de novo purine biosynthesis in the chemotherapy of solid tumors. Mol Pharmacol. 2010 Oct; 78(4):577-87.

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Synthesis and antitumor activity of a novel series of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors and the proton-coupled folate transporter over the reduced folate carrier for cellular entry. J Med Chem. 2010 Feb 11; 53(3):1306-18.

View in: PubMed
Reversible severe combined immunodeficiency phenotype secondary to a mutation of the proton-coupled folate transporter. Clin Immunol. 2009 Dec; 133(3):287-94.

View in: PubMed
Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption. Cell. 2006 Dec 01; 127(5):917-28.

View in: PubMed

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