Heteroduplex Analysis

"Heteroduplex Analysis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A method of detecting gene mutation by mixing PCR-amplified mutant and wild-type DNA followed by denaturation and reannealing. The resultant products are resolved by gel electrophoresis, with single base substitutions detectable under optimal electrophoretic conditions and gel formulations. Large base pair mismatches may also be analyzed by using electron microscopy to visualize heteroduplex regions.

Descriptor ID

D020180

MeSH Number(s)

E05.393.661.250

Concept/Terms

Heteroduplex Analysis

Below are MeSH descriptors whose meaning is more general than "Heteroduplex Analysis".

Analytical, Diagnostic and Therapeutic Techniques and Equipment [E]
Investigative Techniques [E05]
Genetic Techniques [E05.393]
Nucleic Acid Hybridization [E05.393.661]
Heteroduplex Analysis [E05.393.661.250]

Below are MeSH descriptors whose meaning is related to "Heteroduplex Analysis".

Below are MeSH descriptors whose meaning is more specific than "Heteroduplex Analysis".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Heteroduplex Analysis" by people in Harvard Catalyst Profiles by year, and whether "Heteroduplex Analysis" was a major or minor topic of these publication.

Bar chart showing 8 publications over 7 distinct years, with a maximum of 2 publications in 2000

To see the data from this visualization as text, click here.

Year	Minor Topic	Total
1999	1	1
2000	2	2
2001	1	1
2002	1	1
2005	1	1
2006	1	1
2010	1	1

Below are the most recent publications written about "Heteroduplex Analysis" by people in Profiles.

Mutation analysis of 18 nephronophthisis associated ciliopathy disease genes using a DNA pooling and next generation sequencing strategy. J Med Genet. 2011 Feb; 48(2):105-16.

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Hepatitis C virus (HCV) quasispecies complexity and selection in HCV/HIV-coinfected subjects treated with interferon-based regimens. J Infect Dis. 2010 Mar; 201(5):712-9.

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A pattern-based method for the identification of MicroRNA binding sites and their corresponding heteroduplexes. Cell. 2006 Sep 22; 126(6):1203-17.

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Sequential turnover of human immunodeficiency virus type 1 env throughout the course of infection. J Virol. 2006 Nov; 80(21):10591-9.

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Effects of monotherapy with (R)-9-(2-phosphonylmethoxypropyl)adenine (PMPA) on the evolution of a primary Simian immunodeficiency virus (SIV) isolate. Virology. 2006 Oct 10; 354(1):116-31.

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Rapid detection of glucose-6-phosphate dehydrogenase gene mutations by denaturing high-performance liquid chromatography. Clin Biochem. 2005 Nov; 38(11):973-80.

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High-throughput mitochondrial genome screening method for nonmelanoma skin cancer using multiplexed temperature gradient capillary electrophoresis. Clin Chem. 2005 Feb; 51(2):305-11.

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Human immunodeficiency virus type 1 (HIV-1) diversity at time of infection is not restricted to certain risk groups or specific HIV-1 subtypes. J Virol. 2004 Jul; 78(13):7279-83.

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Mismatch cleavage by single-strand specific nucleases. Nucleic Acids Res. 2004; 32(8):2632-41.

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Turnover of env variable region 1 and 2 genotypes in subjects with late-stage human immunodeficiency virus type 1 infection. J Virol. 2003 Jun; 77(12):6811-22.

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